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Journal articles on the topic 'D cognitive impairment'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

R., Rajalakshmi, Chinnappa A. Uthaiah, Ramya C. M., et al. "Comparative assessment of cognitive impairment and oxidative stress markers among vitamin D insufficient elderly patients with and without type 2 diabetes mellitus (T2DM)." PLOS ONE 17, no. 6 (2022): e0269394. http://dx.doi.org/10.1371/journal.pone.0269394.

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Background Disorders of mental health are known to affect cognitive functions, hence called as cognitive disorders. Impaired glucose metabolism, insulin resistance, vitamin-D deficiency and oxidative stress are some of the key early events reported to be involved in the pathogenesis of most common cognitive disorders, which include Alzheimer’s disease. Type-2 diabetes mellitus (T2DM) is one of the known contributing factors of cognitive impairment and dementia. Methods A cross sectional study was carried out in 145 subjects, who were assessed for cognitive function by modified mini mental stat

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Imerbsin, Nalinee, Prapimporn Chattranukulchai Shantavasinkul, Pirada Witoonpanich, et al. "Vitamin D and Cognitive Impairment." Nutrients 17, no. 8 (2025): 1301. https://doi.org/10.3390/nu17081301.

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Background: Vitamin D deficiency is recognized as a significant public health concern, and it has been identified as one of the potentially modifiable risk factors for mild cognitive impairment (MCI). However, evidence regarding the relationship between vitamin D status and cognitive function remains conflicting. Objective: Therefore, this study aimed to examine the prevalence of vitamin D deficiency in the Thai elderly population and an association between vitamin D status and cognitive function, adiposity, and insulin sensitivity. Methods: This study enrolled participants aged 55–80 years wi

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Pinzon, Rizaldy, Vincent Ongko Wijaya, and Dessy Paramitha. "Vitamin D Status and Cognitive Performance of Post Stroke Patients." Molecular and Cellular Biomedical Sciences 5, no. 1 (2021): 22. http://dx.doi.org/10.21705/mcbs.v5i1.170.

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Background: The prevalence of post-stroke cognitive impairment (PSCI) ranges from 20-80%. Some studies found that vitamin D deficiency was common in stroke patients, yet the relationship with cognitive performance remains unclear. The study aimed to investigate the relationship between levels of vitamin D and cognitive performance in post-stroke patients.Materials and Methods: This was a cross-sectional study with 20 post-ischemic stroke patients. Vitamin D levels were measured using enzyme-linked fluorescent assay (ELFA). The cognitive performance was assessed by computerized mini-mental stat

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Farr, Susan A., Kelvin A. Yamada, D. Allan Butterfield, et al. "Obesity and Hypertriglyceridemia Produce Cognitive Impairment." Endocrinology 149, no. 5 (2008): 2628–36. http://dx.doi.org/10.1210/en.2007-1722.

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Obesity is associated with cognitive impairments. Long-term mechanisms for this association include consequences of hyperglycemia, dyslipidemia, or other factors comprising metabolic syndrome X. We found that hypertriglyceridemia, the main dyslipidemia of metabolic syndrome X, is in part responsible for the leptin resistance seen in obesity. Here we determined whether triglycerides have an immediate and direct effect on cognition. Obese mice showed impaired acquisition in three different cognitive paradigms: the active avoidance T-maze, the Morris water maze, and a food reward lever press. The

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Taslim Pinzon, Rizaldy, Nindya Stephanie Christina, Oey Yedida Stephanie Sugianto, and Tillandsia Filli Folia Primastuti. "Correlation between vitamin D levels and cognitive impairment on 90 days post ischemic stroke patients." Romanian Journal of Neurology 21, no. 3 (2022): 237–41. http://dx.doi.org/10.37897/rjn.2022.3.7.

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The prevalence of ischemic stroke based on the American Heart Association (AHA) data in 2019 reached 77.2 million people. As much as 72% of post ischemic stroke patients got cognitive impairment. Vitamin D deficiency is often found in post-stroke patients and causes functional decline. This study aims to assess the relationship between vitamin D levels and cognitive impairment in 90 days post ischemic stroke patients. This study is a cross-sectional study using secondary data from medical records at Bethesda Hospital Yogyakarta taken from January to March 2021. Cognitive impairment in 90 days

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Dye, A., J. Gehling, and J. Buchanan. "C-01 An Evaluative Study of a Cognitive Training Program on Cognitive Outcomes in Older Adults with Moderate to Severe Cognitive Impairment." Archives of Clinical Neuropsychology 34, no. 6 (2019): 1028. http://dx.doi.org/10.1093/arclin/acz034.163.

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Abstract Objective Because medical interventions for persons with dementia have limited effectiveness, there is a need to evaluate non-pharmacological interventions designed to support individuals with cognitive impairment. Cognitive training is a non-pharmacological approach aimed at improving or maintaining cognitive functioning through practice. The current study evaluated the effects of a cognitive training program in older adults with moderate to severe cognitive impairment. Method Data were collected from seven females and one male with a mean age of 83.1 who met criteria for moderate to

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de la Fuente, Javier, Jacob Hjelmborg, Mette Wod, et al. "Longitudinal Associations of Sensory and Cognitive Functioning: A Structural Equation Modeling Approach." Journals of Gerontology: Series B 74, no. 8 (2018): 1308–16. http://dx.doi.org/10.1093/geronb/gby147.

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Abstract Objectives Although visual and hearing impairments have been found to be associated with cognitive decline in the old age, the mechanism underlying this relationship remains unclear. This study aimed at assessing the predictive role of visual and hearing difficulties on subsequent cognitive functioning. Method From the cohort of the first (2002) and fifth waves (2010) of the English Longitudinal Study of Ageing (ELSA), 3,508 individuals aged 60 and older were included in the study. Five self-reported visual and hearing functioning items were used to assess sensory functioning at basel

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Bora, E., B. Binnur Akdede, and K. Alptekin. "Neurocognitive impairment in deficit and non-deficit schizophrenia: a meta-analysis." Psychological Medicine 47, no. 14 (2017): 2401–13. http://dx.doi.org/10.1017/s0033291717000952.

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BackgroundMost studies suggested that patients with deficit schizophrenia have more severe impairment compared with patients with non-deficit schizophrenia. However, it is not clear whether deficit and non-deficit schizophrenia are associated with differential neurocognitive profiles.MethodsThe aim of this meta-analytic review was to compare cognitive performances of deficit and non-deficit patients with each other and with healthy controls. In the current meta-analysis, differences in cognitive abilities between 897 deficit and 1636 non-deficit patients with schizophrenia were examined. Cogni

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Kamyshna, Iryna I., Larysa B. Pavlovych, and Aleksandr M. Kamyshnyi. "Prediction of the cognitive impairment development in patients with autoimmune thyroiditis and hypothyroidism." Endocrine Regulations 56, no. 3 (2022): 178–89. http://dx.doi.org/10.2478/enr-2022-0019.

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Abstract Objective. The aim of the present work is to define the risk factors that can affect the presence of a cognitive impairment and analyze the associations of the brain-derived neurotrophic factor (BDNF) gene polymorphism (rs6265), vitamin D receptor (VDR) gene polymorphism (rs2228570), and N-methyl-D-aspartate (NMDA) receptor gene polymorphism (rs4880213) with the cognitive impairment in patients with autoimmune thyroiditis and hypothyroidism in the Western Ukraine population and predict the development of cognitive disorders in these patients. Methods. The study involved 153 patients w

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Cruz, Daniela, Hélder Balouta, and Rafaela Ventura. "Papel da vitamina D no tratamento do défice cognitivo ligeiro – qual a evidência?" RIAGE - Revista Ibero-Americana de Gerontologia 3 (June 30, 2023): 92–101. http://dx.doi.org/10.61415/riage.45.

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O Défice Cognitivo Ligeiro (DCL) define-se como um decréscimo da função cognitiva, reconhecido pelo próprio e por familiares, que vai mais além das alterações que decorrem da idade. O DCL pode progredir para demência, sendo relevante a prevenção, diagnóstico e tratamento. Vários suplementos foram associados a uma melhoria da função cognitiva, nomeadamente a vitamina D. Este estudo deteve como objetivo rever a evidência do uso de vitamina D no tratamento do DCL. Foi utilizada uma metodologia RBE com critérios de inclusão segundo a metodologia PICO: População – idosos com DCL; Intervenção – supl

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Gao, Ying, Yongquan Xu, and Junfeng Yin. "Selenomethionine Ameliorates Cognitive Impairment, Decreases Hippocampal Oxidative Stress and Attenuates Dysbiosis in D-Galactose-Treated Mice." Antioxidants 11, no. 1 (2022): 111. http://dx.doi.org/10.3390/antiox11010111.

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The prevalence of age-related cognitive impairment is increasing as the proportion of older individuals in the population grows. It is therefore necessary and urgent to find agents to prevent or ameliorate age-related cognitive impairment. Selenomethionine (SeMet) is a natural amino acid occurring in yeast and Brazil nuts. It mitigates cognitive impairment in an Alzheimer’s disease mouse model, however, whether it works on age-related cognitive impairment remains unknown. In this study, SeMet significantly improved the performance of D-galactose-treated mice in the novel object recognition tes

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Hudon, Carol, Sylvie Belleville, and Serge Gauthier. "The association between depressive and cognitive symptoms in amnestic mild cognitive impairment." International Psychogeriatrics 20, no. 4 (2008): 710–23. http://dx.doi.org/10.1017/s1041610208007114.

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ABSTRACTBackground: Depressive symptoms are frequently observed in older adults with mild cognitive impairment (MCI). However, little is known regarding the cognitive characteristics of this important subgroup.Methods: We examined executive functions (controlled inhibition) and verbal episodic memory in 33 healthy older adults (control group), 18 older adults with amnestic MCI plus subclinical depressive symptoms (a-MCI/D+ group), and 26 older adults with amnestic MCI but no depressive symptoms (a-MCI group).Results: Compared to the a-MCI and control groups, patients with a-MCI/D+ showed poor

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Monds, L. A., N. J. Ridley, C. Rivas, A. Withall, B. Draper, and N. Lintzeris. "Cognition and adaptive functioning in older people attending drug and alcohol services." International Psychogeriatrics 29, no. 5 (2017): 815–23. http://dx.doi.org/10.1017/s1041610216002428.

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ABSTRACTBackground:Substance use disorders in older adults are expected to increase dramatically in the coming years. Given the increased susceptibility to cognitive deficits in older substance users (defined here as aged 50+ years due to the accelerated health decline observed in this population), it is important to consider the functional correlates of cognitive impairment in these older adults. This study details the cognitive status of older individuals attending outpatient drug and alcohol (D&A) treatment services and seeks to determine of the association of cognitive impairment to se

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Sánchez-Alcalá, Marcelina, Agustín Aibar-Almazán, María del Carmen Carcelén-Fraile, et al. "Effects of Dance-Based Aerobic Training on Frailty and Cognitive Function in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial." Diagnostics 15, no. 3 (2025): 351. https://doi.org/10.3390/diagnostics15030351.

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Background/Objectives: The purpose of this study has been to evaluate the effects of a dance-based aerobic training program on frailty, cognitive impairment, executive functions, and verbal fluency in older adults with mild cognitive impairment. Methods: Randomized clinical trial, whose sample was made up of 92 older adults, of which 47 performed rhythmic physical activity for 12 weeks. Data on frailty were collected through FRAIL, cognitive function through the Mini-Mental State Examination (MMSE), cognitive impairment through The Montreal Cognitive Assessment (MoCA), verbal fluency using the

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Sultan, Sadia, Uzma Taimuri, Shatha Abdulrzzaq Basnan, et al. "Low Vitamin D and Its Association with Cognitive Impairment and Dementia." Journal of Aging Research 2020 (April 30, 2020): 1–10. http://dx.doi.org/10.1155/2020/6097820.

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Vitamin D is a neurosteroid hormone that regulates neurotransmitters and neurotrophins. It has anti-inflammatory, antioxidant, and neuroprotective properties. It increases neurotrophic factors such as nerve growth factor which further promotes brain health. Moreover, it is also helpful in the prevention of amyloid accumulation and promotes amyloid clearance. Emerging evidence suggests its role in the reduction of Alzheimer’s disease hallmarks such as amyloid-beta and phosphorylated tau. Many preclinical studies have supported the hypothesis that vitamin D leads to attentional, behavioral probl

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Arosio, Beatrice, Paolo Dionigi Rossi, Evelyn Ferri, Matteo Cesari, and Giovanni Vitale. "Characterization of Vitamin D Status in Older Persons with Cognitive Impairment." Nutrients 14, no. 6 (2022): 1142. http://dx.doi.org/10.3390/nu14061142.

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Vitamin D exerts a role in the maintenance of cognitive abilities and in frailty. Although several studies evaluated the interactions between vitamin D and cognitive impairment, results were conflicting. In a cohort of community-dwelling older persons, we described the association between vitamin D levels and cognitive decline and all-cause dementia evaluating frailty’s contribution. Our cohort included 509 adults, aged 64–92 years: 176 patients with mild cognitive impairment (MCI), 59 with Alzheimer’s Disease (AD), 26 with idiopathic Normal Pressure Hydrocephalus (iNPH), 133 with mixed dement

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Sánchez-Torres, A., G. Gil-Berrozpe, R. Lorente-Omeñaca, et al. "Cognitive impairment associated with psychosis (CIAPS): Validity of clinical criteria to detect cognitive impairment." European Psychiatry 64, S1 (2021): S519—S520. http://dx.doi.org/10.1192/j.eurpsy.2021.1390.

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IntroductionEven though cognitive impairment is considered a hallmark of schizophrenia, it has not been included as a criterion into major diagnostic systems.ObjectivesTo test whether a set of clinical-defined cognitive impairment criteria can have utility in the assessment of psychosis patients in clinical practice.MethodsWe assessed 98 patients with a psychotic disorder, diagnosed using DSM 5 criteria. We developed a set of cognitive impairment associated with psychosis (CIAPs) criteria following the format of current DSM criteria and based on previous literature. The CIAPs criteria include:

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Kinder, Renee. "Coding for Mild Cognitive Impairment." Perspectives on Gerontology 19, no. 2 (2014): 72–77. http://dx.doi.org/10.1044/gero19.2.72.

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Appropriate coding when providing skilled therapy interventions for individuals with Mild Cognitive Impairment (MCI) begins by obtaining an adequate understanding of the diagnostic criteria for the disorder. Current diagnostic criteria for MCI include: a. reported change in cognition, which is preferably corroborated by an informant in comparison with previous level with concern of patient, family, or clinician with one or more impaired cognitive domains for age and education. b. decline which is evident over time and greater than expected for age and education in a variety of domains includin

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Llewellyn, David J., Kenneth M. Langa, and Iain A. Lang. "Serum 25-Hydroxyvitamin D Concentration and Cognitive Impairment." Journal of Geriatric Psychiatry and Neurology 22, no. 3 (2008): 188–95. http://dx.doi.org/10.1177/0891988708327888.

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Grant, William B. "Vitamin D and incident dementia and cognitive impairment." American Journal of Clinical Nutrition 106, no. 2 (2017): 699–700. http://dx.doi.org/10.3945/ajcn.117.158568.

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Topolyanskaya, S. V., Kh Kostoeva, N. V. Matsyuk, et al. "Vitamin D and cognitive impairment in geriatric practice." Russian Journal of Geriatric Medicine, no. 2 (May 5, 2025): 164–66. https://doi.org/10.37586/2686-8636-2-2025-164-166.

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INTRODUCTION. Vitamin D is primarily known for its effects on the regulation of calcium homeostasis and bone metabolism, but its receptors have been found in more than 30 human organs and tissues, including the nervous system. Vitamin D deficiency is associated with various diseases, but its role in the formation of extraskeletal pathological conditions requires clarification.

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Dewi, Valentina Tjandra, Anak Agung Ayu Putri Laksmidewi, Anak Agung Ayu Suryapraba, Wira Gotera, I. Putu Eka Widyadharma, and I. Made Oka Adnyana. "Vitamin D Deficiency as a Factor Associated with Cognitive Impairment in Patients with Type 2 Diabetes Mellitus." Siriraj Medical Journal 76, no. 1 (2024): 1–7. http://dx.doi.org/10.33192/smj.v76i1.265476.

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Objective: Vitamin D as an essential nutrient is increasingly being studied and reported to have roles in diabetes and cognitive function through its antioxidant, anti-inflammatory, and neuroprotective functions. This study aimed to investigate vitamin D deficiency as a factor associated with cognitive impairment in Type 2 Diabetes Mellitus patients. Materials and Methods: This case-control study was conducted at the diabetic center and neurology outpatient clinic at Prof. Dr. I.G.N.G Ngoerah Hospital in Denpasar, Indonesia between September and December 2022. Cases had a score of < 26 on t

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Agarwal, Rakesh, Phillip J. Tully, and Rajiv Mahajan. "Cognitive Function in Atrial Fibrillation: A Narrative Review of Evidence and Mechanisms." Heart and Mind 8, no. 2 (2024): 100–110. http://dx.doi.org/10.4103/hm.hm-d-23-00075.

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Atrial fibrillation (AF) is associated with cognitive impairment, with or without history of stroke. The risk of developing cognitive impairment is increased after clinical stroke. Prospective registries confirm the increased risk of both vascular and Alzheimer’s dementia in patients with AF. The purported mechanistic links between AF and cognitive impairment are clinical stroke, subclinical cerebral small-vessel disease, autonomic dysfunction, and systemic and neuroinflammation. Several shared risk factors and genetics also contribute to this interplay. In this review, we explore the evidence

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Montero-Odasso, Manuel, Guangyong Zou, Mark Speechley, et al. "Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment." JAMA Network Open 6, no. 7 (2023): e2324465. http://dx.doi.org/10.1001/jamanetworkopen.2023.24465.

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ImportanceExercise, cognitive training, and vitamin D may enhance cognition in older adults with mild cognitive impairment (MCI).ObjectiveTo determine whether aerobic-resistance exercises would improve cognition relative to an active control and if a multidomain intervention including exercises, computerized cognitive training, and vitamin D supplementation would show greater improvements than exercise alone.Design, Setting, and ParticipantsThis randomized clinical trial (the SYNERGIC Study) was a multisite, double-masked, fractional factorial trial that evaluated the effects of aerobic-resist

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Ryu, Jong-Sik, Ho-Youl Kang, and Jong Kil Lee. "Effect of Treadmill Exercise and Trans-Cinnamaldehyde against d-Galactose- and Aluminum Chloride-Induced Cognitive Dysfunction in Mice." Brain Sciences 10, no. 11 (2020): 793. http://dx.doi.org/10.3390/brainsci10110793.

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Mild cognitive impairment (MCI) generally refers to impairment in cognition above that which accompanies the normal age-related cognitive decline and has attracted attention in recent years. Trans-cinnamaldehyde (TCA), which is isolated from cinnamon, has anti-inflammatory and antioxidant properties. Treadmill exercise also has diverse positive effects. The purpose of this study was to investigate the combination effects of TCA and treadmill exercise on learning and memory in a cognitive impairment mouse induced by a combination of d-galactose (d-gal) and aluminum chloride (AlCl3). We found th

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Bora, E., B. B. Akdede, and K. Alptekin. "The relationship between cognitive impairment in schizophrenia and metabolic syndrome: a systematic review and meta-analysis." Psychological Medicine 47, no. 6 (2016): 1030–40. http://dx.doi.org/10.1017/s0033291716003366.

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BackgroundIndividuals with schizophrenia are at greater risk for metabolic syndrome (MetS) which is associated with cognitive deficits in the general population. MetS might be potentially an important contributing factor to cognitive impairment in schizophrenia.MethodIn the current systematic review and meta-analysis, the findings of 18 studies investigating the association between MetS (and its components) with cognitive impairment in schizophrenia are reviewed.ResultsCo-morbidity of MetS (d = 0.28) and diabetes mellitus (d = 0.28) were both associated with more severe cognitive deficits in s

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Zhang, Mingjie, Yufei Liu, Guanqun Hu, et al. "Cognitive impairment in a classical rat model of chronic migraine may be due to alterations in hippocampal synaptic plasticity and N-methyl-D-aspartate receptor subunits." Molecular Pain 16 (January 2020): 174480692095958. http://dx.doi.org/10.1177/1744806920959582.

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Although migraine is a major global public health problem, its impact on cognitive abilities remains controversial. Thus, the present study investigated the effects of repeated administration of inflammatory soup to the dura of rats, over three weeks, on spatial cognition, hippocampal synaptic plasticity, and the expression of N-methyl-D-aspartate receptor subunits. Additionally, low doses of amitriptyline (5 mg/kg) were applied to assess its therapeutic effects. The inflammatory soup group exhibited significant reductions in the cutaneous stimulation threshold, presence of mild cognitive impa

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Wang, Jiaqi, Rong Huang, Sai Tian, et al. "Elevated Plasma Level of D-dimer Predicts the High Risk of Early Cognitive Impairment in Type 2 Diabetic Patients as Carotid Artery Plaques become Vulnerable or Get Aggravated." Current Alzheimer Research 16, no. 5 (2019): 396–404. http://dx.doi.org/10.2174/1567205016666190321164741.

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Background and Objective: D-dimer prompts fibrinolysis system, which is involved in Alzheimer’s disease and the complications of type 2 diabetic patients, especially among those with carotid artery plaques. Hence, this study aims to investigate the role of D-dimer in early cognitive impairment among type 2 diabetic patients with carotid artery plaques. Methods: A total of 175 Chinese patients with type 2 diabetes were recruited and divided into two groups according to the Montreal Cognitive Assessment score. Demographic data were collected, plasma D-dimer was tested through VIDAS D-dimer New,

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Fu, Mengzhu, Xing Li, Zhenzhen Hu, Caixia Yin, Wenzhuo Dai, and Huihui Song. "Serum levels of 25-OH vitamin D levels predict cognitive impairments among acute coronary syndrome patients." Journal of Cardiovascular Medicine 24, no. 10 (2023): 737–45. http://dx.doi.org/10.2459/jcm.0000000000001542.

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Background The cognitive impairment after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) has become a crucial clinical concern that cannot be ignored. However, studies on the early warning factors of cognitive impairment after PCI are still insufficient. Methods This study reviewed the postoperative cognitive function of 284 patients who underwent PCI in our hospital from June 2019 to June 2022. During the 21-day follow-up, all participants included in the analysis were divided into the cognitive impairment (CI) group (n = 82) and the noncognitive impai

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Janssen, Jolien, Paula S. Koekkoek, Geert-Jan Biessels, Jaap L. Kappelle, and Guy E. H. M. Rutten. "Depressive symptoms and quality of life after screening for cognitive impairment in patients with type 2 diabetes: observations from the Cog-ID cohort study." BMJ Open 9, no. 1 (2019): e024696. http://dx.doi.org/10.1136/bmjopen-2018-024696.

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ObjectivesTo assess changes in depressive symptoms and health-related quality of life (HRQOL) after screening for cognitive impairment in people with type 2 diabetes.DesignA prospective cohort study, part of the Cognitive Impairment in Diabetes (Cog-ID) study.SettingParticipants were screened for cognitive impairment in primary care. People suspected of cognitive impairment (screen positives) received a standardised evaluation at a memory clinic.ParticipantsParticipants ≥70 years with type 2 diabetes were included in Cog-ID between August 2012 and September 2014, the current study includes 179

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Willis, Pamelia F., Thomas J. Farrer, and Erin D. Bigler. "Are Effort Measures Sensitive to Cognitive Impairment?" Military Medicine 176, no. 12 (2011): 1426–31. http://dx.doi.org/10.7205/milmed-d-11-00168.

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Potthoff, Ruben D., Sanne B. Schagen, and Joost A. Agelink van Rentergem. "8 Computational Modeling of Memory Processes in non-CNS Cancer Survivors." Journal of the International Neuropsychological Society 29, s1 (2023): 526–27. http://dx.doi.org/10.1017/s1355617723006793.

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Objective:Cognitive impairment is an often-overlooked issue that non-CNS cancer survivors face. Our current understanding of their issues is lacking, as traditional memory sum scores grant us little insight into the underlying cognitive processes of memory and its impairment. We can improve the informativity of memory impairment studies by isolating which cognitive processes are impaired.Participants and Methods:Participants were breast cancer survivors who received chemotherapy (n=68), and women controls (n=157). The participants completed the Amsterdam Cognition Scan (ACS), in which classica

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Rock, P. L., J. P. Roiser, W. J. Riedel, and A. D. Blackwell. "Cognitive impairment in depression: a systematic review and meta-analysis." Psychological Medicine 44, no. 10 (2013): 2029–40. http://dx.doi.org/10.1017/s0033291713002535.

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BackgroundThis review aimed to address the question of whether cognitive impairment should be considered a core feature of depression that may be a valuable target for treatment.MethodWe conducted a systematic review and meta-analysis of cognitive function, assessed with a single neuropsychological test battery, the Cambridge Neuropsychological Test Automated Battery (CANTAB), in patients with depression during symptomatic and remitted states. Inclusion of studies comparing patients remitted from depression and controls enabled us to investigate whether cognitive impairment persists beyond epi

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Ide, Soichiro, Yuiko Ikekubo, Masayoshi Mishina, Kenji Hashimoto, and Kazutaka Ikeda. "Cognitive Impairment That Is Induced by (R)-Ketamine Is Abolished in NMDA GluN2D Receptor Subunit Knockout Mice." International Journal of Neuropsychopharmacology 22, no. 7 (2019): 449–52. http://dx.doi.org/10.1093/ijnp/pyz025.

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AbstractAlthough the N-methyl-D-aspartate receptor antagonist ketamine has attracted attention because of its rapid and sustained antidepressant effects in depressed patients, its side effects have raised some concerns. Ketamine is a racemic mixture of equal amounts of the enantiomers (R)-ketamine and (S)-ketamine. The neural mechanisms that underlie the differential effects of these enantiomers remain unclear. We investigated cognitive impairment that was induced by ketamine and its enantiomers in N-methyl-D-aspartate GluN2D receptor subunit knockout (GluN2D-KO) mice. In the novel object reco

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Xu, Yan, Meilan Xue, Jing Li, et al. "Fucoidan Improves D-Galactose-Induced Cognitive Dysfunction by Promoting Mitochondrial Biogenesis and Maintaining Gut Microbiome Homeostasis." Nutrients 16, no. 10 (2024): 1512. http://dx.doi.org/10.3390/nu16101512.

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Recent studies have indicated that fucoidan has the potential to improve cognitive impairment. The objective of this study was to demonstrate the protective effect and possible mechanisms of fucoidan in D-galactose (D-gal)-induced cognitive dysfunction. Sprague Dawley rats were injected with D-galactose (200 mg/kg, sc) and administrated with fucoidan (100 mg/kg or 200 mg/kg, ig) for 8 weeks. Our results suggested that fucoidan significantly ameliorated cognitive impairment in D-gal-exposed rats and reversed histopathological changes in the hippocampus. Fucoidan reduced D-gal-induced oxidative

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Rui-hua, Chen, Peng Yong-de, Jiang Xiao-zhen, Jason Chen, and Zhou Bin. "Decreased Levels of Serum IGF-1 and Vitamin D Are Associated With Cognitive Impairment in Patients With Type 2 Diabetes." American Journal of Alzheimer's Disease & Other Dementias® 34, no. 7-8 (2019): 450–56. http://dx.doi.org/10.1177/1533317519860334.

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Purpose: To determine the association of serum insulin-like growth factor 1 (IGF-1) and vitamin D levels with cognition status in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 173 patients with T2DM were recruited and divided into mild cognitive impairment (MCI) group (n = 94) and normal cognition (NC) group (n = 79). Levels of IGF-1 and 25(OH)D were measured and compared, and the correlations among IGF-1, 25(OH)D, and cognitive function were analyzed. Results: Insulin-like growth factor 1 and 25(OH)D levels significantly decreased in MCI group than those in the NC group (

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Jin, Kunpei, Zhengyang Lv, Xinping Pang, et al. "Biomarkers in Alzheimer’s disease progression: a longitudinal cohort study of NPTX2, GRIA1, and GRIA4." Aging Advances 1, no. 1 (2024): 52–59. http://dx.doi.org/10.4103/agingadvances.agingadv-d-24-00004.

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Early diagnosis and intervention are vital for slowing Alzheimer’s disease progression and improving the quality of life in older people. Mild cognitive impairment, an early stage of Alzheimer’s disease, offers a key opportunity for research and intervention. However, current diagnostic methods are typically applied after significant symptoms appear, limiting the effectiveness of early intervention. The data of middle-aged and older individuals collected from the publicly available NCBI datasets GSE5281 and GSE1297 were included in this longitudinal cohort study. The cognitive status changes i

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Golimstok, A., W. Berrios, M. Fernandez, et al. "Vitamin D and progression in Mild Cognitive Impairment (MCI)." Journal of the Neurological Sciences 357 (October 2015): e126. http://dx.doi.org/10.1016/j.jns.2015.08.405.

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Belfort, Tatiana, Marcela Nogueira, Isabel Lacerda, et al. "P43: The pattern of social cognition impairment in young-onset and late-onset Alzheimer’s disease." International Psychogeriatrics 36, S1 (2024): 146–47. http://dx.doi.org/10.1017/s104161022400276x.

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Introduction: People with young-onset Alzheimer’s disease (YOAD) are diagnosed when the neurocognitive process begins before the age of 65 and often present with more global impairments and a more rapid course of the disease. In contrast, in late-onset Alzheimer’s disease (LOAD), the loss of short-term memory is most pronounced. Therefore, the age of onset may affect global functioning in different ways.Objectives: This study examines the relationship between Social Cognition, global cognition, and other clinical variables in young and late-onset people with Alzheimer’s disease and their careg

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Butler Pagnotti, Rachel M., Le Hanh Hua, and Justin B. Miller. "A-70 Differences in Cognition and Disease Characteristics in Adult Vs. Late Onset Multiple Sclerosis." Archives of Clinical Neuropsychology 36, no. 6 (2021): 1112. http://dx.doi.org/10.1093/arclin/acab062.88.

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Abstract Objective Cognitive impairment is a common sequelae of multiple sclerosis(MS), however, relatively little is known about cognitive impairment in late-onset MS (LOMS; symptom onset &gt;50 years old). The present study investigated differences in disease characteristics and cognition in LOMS and adult-onset MS (AOMS). Methods Archival medical records and neuropsychological evaluations from an MS specialty center were reviewed. Differences in disease characteristics between 57 LOMS and 124 AOMS patients were compared using chi-square or ANOVA. To investigate differences in cognitive

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Mustafa Khalid, Norhayati, Hasnah Haron, Suzana Shahar, and Michael Fenech. "Current Evidence on the Association of Micronutrient Malnutrition with Mild Cognitive Impairment, Frailty, and Cognitive Frailty among Older Adults: A Scoping Review." International Journal of Environmental Research and Public Health 19, no. 23 (2022): 15722. http://dx.doi.org/10.3390/ijerph192315722.

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Micronutrient malnutrition is thought to play an important role in the cause of cognitive impairment and physical frailty. The purpose of this scoping review was to map current evidence on the association between micronutrient deficiency in blood and mild cognitive impairment, frailty, and cognitive frailty among older adults. The scoping review was conducted based on the 2005 methodological framework by Arksey and O’Malley. The search strategy for potential literature on micronutrient concentration in blood and cognitive frailty was retrieved based on the keywords using electronic databases (

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Dong, Hyun-Seok, Changsu Han, Sang Won Jeon, et al. "Characteristics of neurocognitive functions in mild cognitive impairment with depression." International Psychogeriatrics 28, no. 7 (2016): 1181–90. http://dx.doi.org/10.1017/s1041610216000314.

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ABSTRACTBackground:Previous studies suggest that there is a strong association between depression and cognitive decline, and that concurrent depressive symptoms in MCI patients could contribute to a difference in neurocognitive characteristics compared to MCI patients without depression. The authors tried to compare neurocognitive functions between MCI patients with and without depression by analyzing the results of neuropsychological tests.Methods:Participants included 153 MCI patients. Based on the diagnosis of major depressive disorder, the participants were divided into two groups: depress

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Jiang, Xinting, Yihan Guo, Liang Cui, Lin Huang, Qihao Guo, and Gaozhong Huang. "Study of Diet Habits and Cognitive Function in the Chinese Middle-Aged and Elderly Population: The Association between Folic Acid, B Vitamins, Vitamin D, Coenzyme Q10 Supplementation and Cognitive Ability." Nutrients 15, no. 5 (2023): 1243. http://dx.doi.org/10.3390/nu15051243.

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A growing body of evidence suggests that vitamin supplements play a role in the prevention of cognitive decline. The objective of the present cross-sectional study was to evaluate the relationship between cognitive ability and folic acid, B vitamins, vitamin D (VD) and Coenzyme Q10 (CoQ10) supplementation. The sample consisted of 892 adults aged above 50 who were assessed for their cognitive status in the Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (China) from July 2019 to January 2022. According to the degree of cognitive impairment, the su

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Greve, A. N., J. R. M. Jepsen, V. Bliksted, et al. "Associations between cognition in parents with schizophrenia or bipolar disorder and their 7-year old high-risk offspring." European Psychiatry 41, S1 (2017): s813. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1578.

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IntroductionNeurocognitive and social cognitive impairments are central characteristics of schizophrenia and, to a lesser extent, of bipolar disorder. Birth cohorts and familial high risk studies have described cognitive impairments in subjects before onset of diagnosis as well as in children with increased genetic risk for development of the disorders.ObjectivesTo our knowledge, this is the first study to investigate the correlations between neurocogntion and social cognition in parents and offspring simultaneously and with the same methodology. We will divide the parents into subgroups (cogn

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Atay, E., C. Ermis, and E. Ozmen. "The Role of The Predominant Polarity on Neurocognitive and Social Cognitive Dysfunctions in Patients with Bipolar Disorder." European Psychiatry 66, S1 (2023): S507—S508. http://dx.doi.org/10.1192/j.eurpsy.2023.1078.

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IntroductionBipolar disorder (BD) is characterized by significant inter-individual variation in terms of course and outcome. The most important factors associated with the outcome are subsyndromal depression and cognitive disability. Predominant polarity (PP), which is a proposed course specifier for BD, can be associated with various clinical differences such as psychotic feature, suicidality, hospitalization, while it is thought to be associated with the severity of cognitive impairment.ObjectivesTo elucidate the role of the predominant polarity on cognitive dysfunction in patients with BD.M

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Liu, Dan, Jiaojiao Liu, Chuanke Hou, Xingyuan Jiang, Haixia Luo, and Hongjun Li. "The pathogenesis of HIV-related neurocognitive impairment and the value of resting state functional imaging for its evaluation: A narrative review." Radiology of Infectious Diseases 11, no. 1 (2024): 1–12. https://doi.org/10.4103/rid.rid-d-24-00003.

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Combined antiviral therapy has extended the life span of people living with HIV, but it has not reduced the incidence rate of neurocognitive impairment. After entering old age, individuals with HIV experience greater cognitive impairment, leading to a decline in the quality of life and an increased social burden. At present, it is widely believed that early neurocognitive impairment is reversible, so the early detection of HIV-related neurocognitive impairment is of great significance. In recent years, resting-state functional magnetic resonance imaging has been widely used in the field of neu

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Hagi, Katsuhiko, Tadashi Nosaka, and Andrei Pikalov. "M48. IS METABOLIC SYNDROME RELATED TO COGNITIVE PERFORMANCE IN PATIENTS WITH SCHIZOPHRENIA? RESULTS FROM A DOUBLE-BLIND, ACTIVE-CONTROLLED, LURASIDONE STUDY." Schizophrenia Bulletin 46, Supplement_1 (2020): S152. http://dx.doi.org/10.1093/schbul/sbaa030.360.

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Abstract Background Schizophrenia is associated with cognitive dysfunction as well as cardiovascular disease (CVD). A central risk factor for CVD is the metabolic syndrome (MetS), which is of special concern in schizophrenia. The prevalence of MetS in U.S. patients with schizophrenia is higher versus general population (32.5% versus 23%). The prevalence of MetS and diabetes mellitus (DM) in those with schizophrenia double that of the general population. Adverse events of some antipsychotics used to treat schizophrenia include weight gain, obesity and other MetS complications, particularly abno

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Al-Khindi, Timour, Konstantine K. Zakzanis, and Wilfred G. van Gorp. "Does Antiretroviral Therapy Improve HIV-Associated Cognitive Impairment? A Quantitative Review of the Literature." Journal of the International Neuropsychological Society 17, no. 6 (2011): 956–69. http://dx.doi.org/10.1017/s1355617711000968.

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AbstractThe development of antiretroviral therapy (ART) has dramatically improved survival for those living with human immunodeficiency virus (HIV), but whether ART improves cognitive functioning remains unclear. The aim of the present review was to examine systematically the extent to which ART improves cognition among individuals with HIV using meta-analytic methods. Twenty-three studies were included in the quantitative review. ART was associated with modest improvements in attention (mean d = .17; p < .001; 95% confidence interval [CI], .09/.25), executive function (mean d = .18; p <

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del Ser, Teodoro, María-Ascensión Zea, Meritxell Valentí, et al. "Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people." Journal of Psychopharmacology 33, no. 8 (2019): 965–74. http://dx.doi.org/10.1177/0269881119857206.

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Background:Chronic drug intake has been associated with negative and positive cognitive effects in elderly people, although subjacent conditions may be confounding factors.Aim:To study the effects on cognitive performance of commonly prescribed medications in a cohort of cognitively normal older adults.Methods:Medication intake was recorded during two years in 1087 individuals 70–85 years old, without neurological or psychiatric conditions. The influence of every drug, drug family and therapeutic group on six cognitive scores and on the conversion to mild cognitive impairment over two years wa

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Banjac Baljak, Visnja, Goran Mihajlovic, Nera Zivlak-Radulovic, Lana Nezic, Mirjana Miskovic, and Vesna Banjac. "Association between Vitamin D and Cognitive Deficiency in Alcohol Dependence." Healthcare 10, no. 9 (2022): 1772. http://dx.doi.org/10.3390/healthcare10091772.

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There are still not enough findings to elucidate how exactly alcohol use impairs cognitive abilities. Some studies have shown that there is a link between alcohol intake and vitamin D levels, but these findings are inconsistent so further research is needed. The aim of this study was to investigate the association between serum vitamin D levels and cognitive impairment in alcohol-dependent individuals. A case-control study was carried out including a total of N = 132 respondents with a medical history of alcoholism, and healthy volunteers. The Montreal Cognitive Assessment (MoCa) and Addenbroo

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