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Dissertations / Theses on the topic 'D-enantiomer'

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Published: 4 June 2021
Last updated: 16 February 2022

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1

Zreika, Sami. "Etude de l'impact de la protéine antimicrobienne humaine hCAP18/LL-37 sur le cancer du sein." Thesis, Tours, 2011. http://www.theses.fr/2011TOUR4052.

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Le peptide hCAP18/LL-37, une partie de la défense immunitaire innée, a maintenant été reconnu comme multifonctionnelle pour les cellules eucaryotes. Nos études démontrent sa contribution au développement du cancer, montrant qu'il est surexprimé dans la plupart des tumeurs mammaires humaines, active la signalisation la famille de ERBB et augmente le potentiel métastatique des cellules cancéreuses du sein. Notre comparaison des deux lignées du cancer du sein n'a pas révélé de récepteurs communs, mais une structure peptidique identiques mais de chiralité différente est pré requis pour le peptide dans toutes ses activités. Nous émettons l'hypothèse que LL-37 active indirectement des récepteurs transmembranaires en se liant à la membrane cellulaire. Des peptides tronqués dérivés de LL-37 inhibent ses activités et peuvent aider à concevoir une future thérapie anticancéreuse
The peptide hCAP18/LL-37, part of the innate immune defense, has now been recognized as multifunctional for eukaryotic cells. Our studies demonstrate its contribution to cancer development, showing that it is overexpressed in most human breast tumors, activates ERBB signaling and increases the metastatic potential of breast cancer cells. Our comparison on two breast cancer lines did not reveal any common receptors but identical structural prerequisites for the peptide in all its activities. We hypothesize that LL-37 indirectly activates transmembrane receptors by attaching to the cellular membrane. Truncated derivatives inhibit its activities and may help to design a future anticancer therapy
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2

Kwok, Hoi-shan, and 郭凱珊. "The comparison of biological properties of L- and D-enantiomeric antimicrobial peptides." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206507.

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Antibiotics have been used widely for the treatment of bacterial infections for over half a century. However, the emergence of resistance to antibiotics has aroused public health concern, leading to the development of antimicrobial peptides (AMPs) as potential alternative therapeutic agents against bacterial infections. AMPs are naturally found in many species and have important roles in our innate immune defense systems. AMPs are usually cationic amphipathic peptides with membrane destabilizing property. They have a relatively broad spectrum of antimicrobial activity and pathogens are less likely to develop resistance against AMPs. The major challenge of using AMPs as therapeutic agents is their toxicity towards mammalian cells. The biological stability of AMPs to protease in human body is another concern. To address the latter problem, instead of the naturally occur L-enantiomers, Denantiomeric AMPs were introduced to enhance their stability. This study aimed to test the hypothesis that the D-enantiomeric AMPs are more resistant than the Lenantiomeric AMPs against proteolytic degradation. Three pairs of synthetic D-/LAMPs (D-LAO160-P13/LAO160-P12; D-LAO160-H/LAO160-H; and D-LAK-120-HP13/LAK-120-HP13) were employed to test for their stability when treated with trypsin, serum and gastric fluid, and the samples were analyzed by high performance liquid chromatography (HPLC). Generally, all the D-enantiomeric AMPs were found to be resistant towards proteolysis. Besides, to compare the cytotoxicity of D-/LAMPs, MTT and LDH assays of the D/L-LAK120-HP13 pair were carried out on two different cell lines, A549 cells (human lung adenocarcinoma epithelial cells) and RAW264.7 cells (mouse macrophage cells). Significant difference in cytotoxicity of D-LAK120-HP13 and LAK120-HP13 on RAW264.7 cells were obtained from MTT assay, but not in LDH assays or on A549 cells. Further analysis has to be done to validate the findings obtained from this research.
published_or_final_version
Pharmacology and Pharmacy
Master
Master of Medical Sciences
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3

Fraunholz, Thomas [Verfasser], and R. H. W. [Akademischer Betreuer] Hoppe. "Transport at Interfaces in Lipid Membranes and Enantiomer Separation / Thomas Fraunholz. Betreuer: R. H. W. Hoppe." Augsburg : Universität Augsburg, 2015. http://d-nb.info/1077705638/34.

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4

Combs, Carolyn C., Erin L. Hankins, Cara L. Copeland, Stacy D. Brown, and Brooks B. Pond. "Quantitative Determination of D- and L- Enantiomers of Methylphenidate in Brain Tissue by Liquid Chromatography-Mass Spectrometry." Digital Commons @ East Tennessee State University, 2013. https://doi.org/10.1002/bmc.2975.

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Methylphenidate, a psychostimulant used for the treatment of attention deficit hyperactivity disorder and narcolepsy, is administered as a 50:50 racemic mixture, despite the fact that d‐methylphenidate has been shown to have greater pharmacologic activity. This paper presents a validated LC‐MS/MS approach to separation and quantification of methylphenidate enantiomers using a vancomycin column and triethylammonium acetate to enhance the chiral separation. The method is applicable to the monitoring of these enantiomers in mouse brain, with a limit of detection of 0.5 ng/mL and a lower limit of quantification of 7.5 ng/mL.
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5

Allen, Jeremy Thomas. "Uptake of D- and L-amino acid enantiomers by protoscoleces and secondary hydatid cysts of Echinococcus granulosus (Cestoda)." Thesis, Keele University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334748.

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6

Peters, Haley T., Stacy D. Brown, Brooks Pond, and Lauren G. Strange. "Quantitative Determination of D- and L- Enantiomers of Methylphenidate in Placenta and Fetal Brain Tissue by Liquid Chromatography-Mass Spectrometry." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/5282.

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7

Dunkelmann, Tina Verfasser], Dieter [Gutachter] [Willbold, and Karl-Josef [Gutachter] Langen. "Evaluation von D-enantiomeren Peptiden als mögliche Wirkstoffkandidaten in einem Alzheimer-Mausmodell / Tina Dunkelmann ; Gutachter: Dieter Willbold, Karl-Josef Langen." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1121745709/34.

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8

Jiang, Nan Verfasser], and Dieter [Akademischer Betreuer] [Willbold. "Preclinical pharmacokinetics and cerebral distribution of D-enantiomeric peptides for the treatment of Alzheimer’s disease / Nan Jiang ; Betreuer: Dieter Willbold." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1150918845/34.

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9

Jiang, Nan [Verfasser], and Dieter [Akademischer Betreuer] Willbold. "Preclinical pharmacokinetics and cerebral distribution of D-enantiomeric peptides for the treatment of Alzheimer’s disease / Nan Jiang ; Betreuer: Dieter Willbold." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1150918845/34.

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10

Dunkelmann, Tina [Verfasser], Dieter [Gutachter] Willbold, and Karl-Josef [Gutachter] Langen. "Evaluation von D-enantiomeren Peptiden als mögliche Wirkstoffkandidaten in einem Alzheimer-Mausmodell / Tina Dunkelmann ; Gutachter: Dieter Willbold, Karl-Josef Langen." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1121745709/34.

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11

Schartmann, Anna Elena [Verfasser], Dieter [Gutachter] Willbold, Karl-Josef [Gutachter] Langen, and Peter [Gutachter] Bayer. "Pharmakokinetische Charakterisierung D-enantiomerer Peptide zur Therapie der Alzheimer'schen Demenz / Anna Elena Schartmann ; Gutachter: Dieter Willbold, Karl-Josef Langen, Peter Bayer." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1156007798/34.

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12

Schemmert, Sarah [Verfasser], Dieter [Gutachter] Willbold, Karl-Josef [Gutachter] Langen, and Heinrich [Gutachter] Sticht. "In vivo Charakterisierung Amyloid-β-Oligomer eliminierender D-enantiomerer Peptide zur Therapie der Alzheimer’schen Demenz / Sarah Schemmert ; Gutachter: Dieter Willbold, Karl-Josef Langen, Heinrich Sticht." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1156007801/34.

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13

Malhis, Marwa [Verfasser], and Susanne Aileen [Akademischer Betreuer] Funke. "Selection and characterization of D-enantiomeric peptides for the investigation of options for therapy and diagnosis of Alzheimer’s disease / Marwa Malhis ; Betreuer: Susanne Aileen Funke." Bayreuth : Universität Bayreuth, 2021. http://d-nb.info/1240309651/34.

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14

Funck-Brentano, Christian. "Contribution des metabolites genetiquement formes et des enantiomeres a l'action des medicaments antiarythmiques chez l'homme : application au procainamide, a l'encainide, a la propafenone et d-sotalol." Paris 6, 1990. http://www.theses.fr/1990PA066138.

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Les medicaments antiarythmiques sont generalement caracterises par un faible index therapeutique. Plusieurs de ces medicaments forment des metabolites actifs, parfois de maniere genetiquement determinee ou sont administres sous forme racemique. Apres une synthese bibliographique sur les facteurs de variabilite de la reponse aux medicaments antiarythmiques, nous presentons six travaux originaux ayant explore quelques-uns de ces facteurs. En premier lieu, nous avons etudie la contribution des principaux metabolites du procainamide, de l'encainide et de la propafenone, dont la formation est genetiquement determinee a l'action du produit parent. Pour le procainamide, nous nous sommes egalement interesses a l'influence du metabolite sur la pharmacocinetique du produit parent. En second lieu, nous avons etudie les proprietes et la cinetique des deux enantiomeres de la propafenone et les effets sur la frequence cardiaque de l'enantiomere d-(+)- du sotalol. Les resultats des differents travaux presentes soulignent l'importance d'etudes specifiques des enantiomeres des antiarythmiques et des metabolites, en particulier de ceux dont la formation est genetiquement determinee, afin de preciser le role de ces facteurs dans la variabilite de la reponse a l'administration des antiarythmiques chez l'homme
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15

Rudolph, Stephan Verfasser], Dieter [Akademischer Betreuer] [Willbold, and Georg [Akademischer Betreuer] Groth. "Selection and characterization of Amyloid-β1-42 binding D-enantiomeric peptides for potential therapeutic intervention of Alzheimer´s disease / Stephan Rudolph. Betreuer: Dieter Willbold. Gutachter: Georg Groth." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1099593328/34.

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16

Rudolph, Stephan [Verfasser], Dieter [Akademischer Betreuer] Willbold, and Georg [Akademischer Betreuer] Groth. "Selection and characterization of Amyloid-β1-42 binding D-enantiomeric peptides for potential therapeutic intervention of Alzheimer´s disease / Stephan Rudolph. Betreuer: Dieter Willbold. Gutachter: Georg Groth." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1099593328/34.

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17

Hagen, Torsten [Verfasser]. "Darstellung von enantiomer einheitlichen Tris(hydroxymethyl)methan-Derivaten / eingereicht von Torsten Hagen." 2000. http://d-nb.info/961028734/34.

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18

Schimperková, Tereza. "Určování asociačních konstant komplexů enantiomerů dipeptidu β-Ala-D,L-Tyr a jeho derivátů s 2-hydroxypropyl-β-cyklodextrinem kapilární elektroforézou." Master's thesis, 2008. http://www.nusl.cz/ntk/nusl-290770.

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19

Wu, Shing-Chen, and 吳幸真. "On-line derivatization fluorescence detection coupled 2-D HPLC for amino acid enantiomers analysis from aspartame thermal hydrolysis in Coca Cola Zero." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/xx89y7.

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碩士
中原大學
化學研究所
98
A two-dimensional high-performance liquid chromatography (2-D HPLC) system was developed by combining an ultraviolet detector coupled reversed-phase chromatography and a fluorescence detector coupled ligand-exchange chromatography (LEC) with column-switching technique to study the thermal hydrolysis of aspartame in Coca-Cola Zero. Aspartame was quantified by the matrix matched external standard calibration curve method. The linear concentration range of the external standard calibration curve was of 0~50 μg mL-1 and possessed a linear corrlelation coefficient of 0.9984 which gave a limit of detection (LOD) of 1.3 μg mL-1. The amino acid enantiomers produced from the thermal hydrolysis of aspartame was separated by ligand-exchange column and detected by on-line postcolumn fluorescence derivatization fluorescence detection. The quantitative analysis was made by the matrix matched internal standard calibration method and 4 μg mL-1 D-leucine was used as the internal standard. The linear concentration range of the four internal standard calibration curves for the four amino acid enantiomers (D- and L-aspartic acid and D- and L-phenylalanine was all in the range of 0~10 μg mL-1 and their linear correlation coefficients were in the range of 0.9988-0.9997. The LODs obtained from the four standard calibration curves of D- and L-aspartic acid and D- and L-phenylalanine were all 0.2 μg mL-1. However, the LOD for D- and L-aspartic acid and D- and L-phenylalanine with ultraviolet detection was 2.5 and 2.6 μg mL-1 , respectively. Therefore, the sensitivity of flurorescence detection for amino acid enantiomers was 12-13 folds better than that of the ultraviolet detection. The thermal hydrolysis of aspartame in Coca-Cola Zero was performed with a special designed mricro-reactor and at four different temperatures (37, 60, 90 and 120℃) for one day or more than one day. The yield was 2.1%～19.3% for D,L-aspartic acid and 2.5%～21.3% for D,L-phenylalanine acid, respectively. The thermal hydrolysis of aspartame was also performed by microwave heating and tested at three different powers (320 W, 560 W, and 800 W) for 1 or 3 minutes. Only L-aspartic acid was produced with yields of 2.1% ~ 2.3%. The analysis accuracy tested by the spike experiments were 90%~99%. The relative standard deviations (RSDs) of repeated sample measurements were all smaller than 6.7%. Therefore, the developed 2D-HPLC not only can simultaneously determine the dipeptide aspartame but also can determine its four thermal hydrolysis amino acid enantiomer products with high sensitivity, accuracy, and precision.
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