Academic literature on the topic 'D. melanogaster'

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Journal articles on the topic "D. melanogaster"

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Vieira, C., and C. Biémont. "Selection against transposable elements in D. simulans and D. melanogaster." Genetical Research 68, no. 1 (1996): 9–15. http://dx.doi.org/10.1017/s0016672300033838.

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SummaryThe insertion site numbers of the transposable elements (TEs) copia, mdgl, 412 and gypsy were determined in various natural populations of Drosophila melanogaster and D. simulans by in situ hybridization. We showed that, while all elements except gypsy had many insertion sites scattered over the chromosomes in D. melanogaster, only the 412 element in D. simulans presented a high number of insertions, and this number was lower than in D. melanogaster. This low 412 site number per genome in D. simulans was associated with a lower proportion of insertions on the X chromosome in comparison
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Sánchez, Lucas, and Pedro Santamaria. "Reproductive Isolation and Morphogenetic Evolution in Drosophila Analyzed by Breakage of Ethological Barriers." Genetics 147, no. 1 (1997): 231–42. http://dx.doi.org/10.1093/genetics/147.1.231.

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Abstract This article reports the breaking of ethological barriers through the constitution of soma-germ line chimeras between species of the melanogaster subgroup of Drosophila, which are ethologically isolated. Female Drosophila yakuba and D. teissieri germ cells in a D. melanogaster ovary produced functional oocytes that, when fertilized by D. melanogaster sperm, gave rise to sterile yakuba-melanogaster andteissieri-melanogaster male and female hybrids. However, the erecta-melanogaster and orena-melanogaster hybrids were lethal, since female D. erecta and D. orena germ cells in a D. melanog
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Moschetti, Roberta, Corrado Caggese, Paolo Barsanti, and Ruggiero Caizzi. "Intra- and Interspecies Variation Among Bari-1 Elements of the Melanogaster Species Group." Genetics 150, no. 1 (1998): 239–50. http://dx.doi.org/10.1093/genetics/150.1.239.

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Abstract We have investigated the distribution of sequences homologous to Bari-1, a Tc1-like transposable element first identified in Drosophila melanogaster, in 87 species of the Drosophila genus. We have also isolated and sequenced Bari-1 homologues from D. simulans, D. mauritiana, and D. sechellia, the species constituting with D. melanogaster the melanogaster complex, and from D. diplacantha and D. erecta, two phylogenetically more distant species of the melanogaster group. Within the melanogaster complex the Bari-1 elements are extremely similar to each other, showing nucleotide identity
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Kuhn, David T., and Th E. Sprey. "Regulation of NADP-Malic Enzyme in the Eye-Antennal Disc of D. melanogaster/D. simulans Hybrids: Evidence for cis- and trans-Regulation." Genetics 115, no. 2 (1987): 277–81. http://dx.doi.org/10.1093/genetics/115.2.277.

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ABSTRACT Pattern regulation of malic enzyme (ME) distribution in D. melanogaster/D. simulans (mel/sim) hybrid eye-antennal discs was investigated. Both cis- and trans-regulation of the spatial distribution pattern was observed within the eye portion of the disc complex. D. simulans possesses gene(s) that operate in trans in the hybrids to suppress ME staining along the morphogenetic furrow, a region that always stains in D. melanogaster. ME structural genes of both species were expressed in cis within the ommatidial preclusters and clusters of the hybrids. Malic enzyme was not expressed elsewh
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Taufika, Ramadhan. "PERBEDAAN STRAIN DAN UMUR BETINA TERHADAP JUMLAH KETURUNAN LALAT BUAH (Drosophila melanogaster Meigen)." Jurnal TAMBORA 4, no. 1 (2020): 50–56. http://dx.doi.org/10.36761/jt.v4i1.573.

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A study was conducted on the differences in strain and female age on the number of descendants of fruit flies (Drospohila melanogaster Meigen) to determine the effect of strain and female age on the number of D. melanogaster offspring in normal, taxi and sepia strains. Five D. melanogaster ♂ normal crossed with 5 D. D. melanogaster ♀ normal, 5 D. melanogaster ♂ taxi crossed with 5 D. D. melanogaster ♀ taxi, 5 D. D. melanogaster ♂ sepia crossed with 5 D. D. melanogaster ♀ sepia. Age of the crossed female is 8-10 hours, 12-14 hours, 16-18 hours, 20-22 hours, and 24-26 hours after hatching from t
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Orr, H. Allen, Laurence D. Madden, Jerry A. Coyne, Renee Goodwin, and R. Scott Hawley. "The Developmental Genetics of Hybrid Inviability: A Mitotic Defect in Drosophila Hybrids." Genetics 145, no. 4 (1997): 1031–40. http://dx.doi.org/10.1093/genetics/145.4.1031.

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We report studies of the developmental basis of hybrid inviability in the Drosophila melanogaster complex. The pathology of these hybrids closely resembles that of mitotic mutants in D. melanogaster. We use mosaic and cytological analyses to show that hybrid male inviability is associated with, and probably caused by, a defect in mitotic cell division. In the mosaic study, we find that male clones produced in otherwise female hybrids are not cell lethal but are very small, probably reflecting defects in mitotic proliferation. Cytological inspection of larval neuroblasts reveals a profound mito
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Luo, Liqun. "Trio Quartet in D. ( melanogaster )." Neuron 26, no. 1 (2000): 1–2. http://dx.doi.org/10.1016/s0896-6273(00)81129-0.

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Nefedova, Lidiya N., Dmitry O. Korostin, Maria V. Potapova, Natalia I. Romanova, and Alexander I. Kim. "MOLECULAR-GENETIC ANALYSIS OF THE DIP1 REGULATOR GENE IN VARIOUS SPECIES OF DROSOPHILA." Ecological genetics 7, no. 4 (2009): 8–13. http://dx.doi.org/10.17816/ecogen748-13.

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The DIP1 is a regulator gene of D. melanogaster with an unknown function. As a result of mRNA alternative splicing, at least 6 coding sequences are formed (DIP1-c/Klett-c, DIP1-b/ Klett-d, DIP1-d, DIP1-а, Klett-a, and Klett-b). Structure and expression of DIP1 homologues in various species of the melanogaster subgroup, such as D. melanogaster, D. sechellia, D. mauritiana, D. simulans, D. erecta,and D. yakuba, have been analyzed. In D. sechellia, D. simulans, and D. mauritiana we found alterations, which affected expression of the DIP1 homologues in contrast to D. melanogaster, D. erecta, and D
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Rogers, Abigail, Lesley Towery, Amanda McCown, and Kimberly A. Carlson. "Impaired Geotaxis as a Novel Phenotype of Nora Virus Infection of Drosophila melanogaster." Scientifica 2020 (July 30, 2020): 1–6. http://dx.doi.org/10.1155/2020/1804510.

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Nora virus (NV) is a picorna-like virus that contains a positive-sense, single-stranded RNA genome. The virus infects Drosophila melanogaster with no known characterized phenotype. In this study, geotaxis assays and longevity analyses were used to determine if Nora virus infection affects D. melanogaster’s locomotor ability. In addition, Drosophila C virus (DCV), a well-characterized D. melanogaster virus, was used as a positive control, as it has previously shown a locomotor defect in infected flies. Stocks infected with NV (NV+) and DCV (DCV+) and virus-free (NV-/DCV-) stocks were establishe
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Lefèvre, Thierry, Jacobus C. de Roode, Balint Z. Kacsoh, and Todd A. Schlenke. "Defence strategies against a parasitoid wasp in Drosophila : fight or flight?" Biology Letters 8, no. 2 (2011): 230–33. http://dx.doi.org/10.1098/rsbl.2011.0725.

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Hosts may defend themselves against parasitism through a wide variety of defence mechanisms, but due to finite resources, investment in one defence mechanism may trade-off with investment in another mechanism. We studied resistance strategies against the parasitoid wasp Leptopilina boulardi in two Drosophila species. We found that D. melanogaster had significantly lower physiological resistance against L. boulardi than D. simulans , and hypothesized that D. melanogaster might instead invest more heavily in other forms of defence, such as behavioural defence. We found that when given a choice b
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Dissertations / Theses on the topic "D. melanogaster"

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Broderick, Kate Elizabeth. "Cyclic GMP - dependent signalling in D. melanogaster Malpighian tubules." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252518.

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Gutzwiller, Florence. "Evolution and gene expression of Wolbachia in D. melanogaster." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/evolution-and-gene-expression-of-wolbachia-in-d-melanogaster(621f6995-e64b-40bc-8765-8eb48a8ce0cf).html.

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Wolbachia is a facultative endosymbiont infecting D. melanogaster, among many other arthropod species. In D. melanogaster, Wolbachia is a reproductive manipulator, but also gives some benefits to its host, such as protection against viruses. We used open access libraries of D. melanogaster resequencing data and yet unpublished sequences from our lab, to study the phylogenomics and geographical diversity of Wolbachia in D. melanogaster from five continents. We confirmed the clade structure of Wolbachia infecting D. melanogaster and the vertical transmission of Wolbachia from a single ancestral
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Osterried, Lea [Verfasser], Michael [Akademischer Betreuer] Köttgen, and Alexis [Akademischer Betreuer] Hofherr. "Untersuchung der Eigenschaften des Ionenkanals TRPP2 in D. melanogaster." Freiburg : Universität, 2019. http://d-nb.info/1207269670/34.

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Vincent, Amanda. "A D. melanogaster parkin mutant larval model of Parkinson's Disease." Thesis, University of York, 2013. http://etheses.whiterose.ac.uk/7535/.

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Parkinson’s Disease (PD) is a neurodegenerative disease, with severely reduced movement in patients. The main effect is the loss of dopaminergic neurons in the central nervous system (CNS). Null mutations of the parkin gene are known to cause PD. I found that Drosophila melanogaster (D. melanogaster) parkin null (dparkin) mutant larvae show neurophysiological abnormalities, a bradykinesia-like locomotory defect and synaptic overgrowth at the neuromuscular junction (NMJ). Neuronal overgrowth is rescued with either muscle or neuronal expression of wild-type dparkin in dparkin mutant larvae. The
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Jackson, Catherine. "Gfat1/zeppelin is an essential heterochromatic gene involved in cuticle formation in D. melanogaster /." Burnaby B.C. : Simon Fraser University, 2007. http://ir.lib.sfu.ca/handle/1892/9354.

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Thesis (M.Sc.) - Simon Fraser University, 2007.<br>Theses (Dept. of Molecular Biology and Biochemistry) / Simon Fraser University. Senior supervisor: Dr. Barry M. Honda -- Dept. of Molecular Biology and Biochemistry. Also issued in digital format and available on the World Wide Web.
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Masrouha, Nisrine. "Functional analysis of the Drosophila chk2 gene, loki : analysis of novel genetic interactors of Bic-D in Drosophila melanogaster." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80329.

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Cell cycle checkpoints are signal transduction pathways that control the order and timing of cell cycle transitions, ensuring that critical events are completed before the cell cycle proceeds. The Chk2 family of kinases plays a central role in mediating responses to DNA damage or DNA replication blocks in various organisms. My functional analysis of the Drosophila serine/threonine kinase Loki/Chk2 shows that fly chk2 monitors double-strand breaks caused by irradiation during S and G2 phases and induces cell cycle arrest in embryonic cells around cellularization.<br>loki is also required
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Emsley, Jason G. "Computer 3-D reconstruction of the embryonic CNS of Drosophila melanogaster." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ36434.pdf.

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Martin, Jennifer. "A Male-killing Bacterium Targets the Neural Tissue in D. melanogaster." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/scripps_theses/275.

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Bacteria living within the cells of eukaryotic organisms can have profound effects on their hosts. One example is host sex-ratio distortion caused by bacterial endosymbionts, which can be induced through the killing of male progeny during their development. The mechanisms that underlie how bacteria can cause male death are poorly understood. Several previous studies suggested that the neural, and perhaps other, tissues are targeted by the male-killing bacterium, Spiroplasma.In this study, I tested this hypothesis, addressing whether tissues were specifically altered during male development and
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Sealfon, Rachel (Rachel Sima). "Predicting enhancer regions and transcription factor binding sites in D. melanogaster." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62434.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 71-75).<br>Identifying regions in the genome that have regulatory function is important to the fundamental biological problem of understanding the mechanisms through which a regulatory sequence drives specific spatial and temporal patterns of gene expression in early development. The modENCODE project aims to comprehensively identify functional elements in the C. elegans and D. melanogaster genomes.
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Ma, Hsiu-Ching. "Discovery and characterisation of new miRNAs during embryogenesis of D. melanogaster." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609448.

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Books on the topic "D. melanogaster"

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Ananʹev, E. V. Ėletronno-mikroskopicheskai͡a︡ karta politennykh khromosom sli͡u︡nnykh zhelez drozofily: D. melanogaster. "Nauka", 1985.

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Benchorin, Gillie. The role of Distal antenna in the regulation of D. melanogaster neural stem cell competence. [publisher not identified], 2022.

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Ennis, Maurice. Tumour necrosis factor alpha and ultraviolet light activation of programmed cell death by apoptosis in D. melanogaster. National Library of Canada, 2001.

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Transcriptional regulation in the female germ line of D. melanogaster. 1993.

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The effects of heat shock on RNA structure and stability in D. melanogaster: A study of processes involving the 3' untranslated region of hsp70 RNA. 1993.

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Book chapters on the topic "D. melanogaster"

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Dempsey, Brian R., Anne C. Rintala-Dempsey, Gary S. Shaw, et al. "Scalloped (Sd) (D. Melanogaster)." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101229.

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Morton, Richard A., Madhu Choudhary, Marie-Louise Cariou, and Rama S. Singh. "A reanalysis of protein polymorphism in Drosophila melanogaster, D. simulans, D. sechellia and D. mauritiana: effects of population size and selection." In Drosophila melanogaster, Drosophila simulans: So Similar, So Different. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-94-007-0965-2_9.

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Sawamura, Kyoichi, Timothy L. Karr, and Masa-Toshi Yamamoto. "Genetics of hybrid inviability and sterility in Drosophila: dissection of introgression of D. simulans genes in D. melanogaster genome." In Drosophila melanogaster, Drosophila simulans: So Similar, So Different. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-94-007-0965-2_21.

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Rouault, Jacques-Deric, Charlotte Marican, Claude Wicker-Thomas, and Jean-Marc Jallon. "Relations between cuticular hydrocarbon (HC) polymorphism, resistance against desiccation and breeding temperature; a model for HC evolution in D. melanogaster and D. simulans." In Drosophila melanogaster, Drosophila simulans: So Similar, So Different. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-94-007-0965-2_16.

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Karpova, Yaroslava, and Alexei V. Tulin. "Generating PARP Knockout D. melanogaster with CRISPR/Cas9 System." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2891-1_21.

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David, Jean R., Roland Allemand, Pierre Capy, et al. "Comparative life histories and ecophysiology of Drosophila melanogaster and D. simulans." In Drosophila melanogaster, Drosophila simulans: So Similar, So Different. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-94-007-0965-2_13.

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Veuille, Michel, Emmanuelle Baudry, Matthew Cobb, Nicolas Derome, and Emmanuelle Gravot. "Historicity and the population genetics of Drosophila melanogaster and D. simulans." In Drosophila melanogaster, Drosophila simulans: So Similar, So Different. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-94-007-0965-2_5.

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Fleury, F., N. Ris, R. Allemand, P. Fouillet, Y. Carton, and M. Boulétreau. "Ecological and genetic interactions in Drosophila-parasitoids communities: a case study with D. melanogaster, D. simulans and their common Leptopilina parasitoids in south-eastern France." In Drosophila melanogaster, Drosophila simulans: So Similar, So Different. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-94-007-0965-2_15.

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Merçot, Hervé, and Sylvain Charlat. "Wolbachia infections in Drosophila melanogaster and D. simulans: polymorphism and levels of cytoplasmic incompatibility." In Drosophila melanogaster, Drosophila simulans: So Similar, So Different. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-94-007-0965-2_4.

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Mousset, Sylvain, and Nicolas Derome. "Molecular polymorphism in Drosophila melanogaster and D. simulans: what have we learned from recent studies?" In Drosophila melanogaster, Drosophila simulans: So Similar, So Different. Springer Netherlands, 2004. http://dx.doi.org/10.1007/978-94-007-0965-2_7.

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Conference papers on the topic "D. melanogaster"

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Grauda, Dace, Andra Miķelsone, Dalius Butkauskas, et al. "Protective properties of biotextile indicated by immature gamete cells flow cytometry and Drosophila melanogaster survival tests." In 79th International Scientific Conference of the University of Latvia. University of Latvia, 2022. http://dx.doi.org/10.22364/iarb.2021.06.

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The testing of an innovative amber-containing biotextile developed within the EUREKA project IFSITEX revealed the ability of biotextile material to protect test objects from UV-B radiation and extremely low-frequency electromagnetic fields (ELF-EMFs). One of two different testing methods is based on flow cytometry indicating changes in the relative fluorescence of immature plant gametes based on the determination of the sum of changes in approximately 20 various parameters of gametic cells affected in one nuclear stage by irradiation of cell suspension covered with biotextile fabrics containin
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Butnaru, Gallia, and Sorina Popescu. "Molecular profile of the D. melanogaster mutant genotype w1118 in the presence of variable amount of deuterium (D)." In VIIth International Scientific Conference “Genetics, Physiology and Plant Breeding”. Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, 2021. http://dx.doi.org/10.53040/gppb7.2021.31.

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The Drosophila melanogaster w1118 mutant line was used to identify the effect of deuterium (D) on DNA synthesis. D concentrations ranged from 30ppm to 96.89% (low and very high amount respec-tively). Five generations of flies were bred on culture media prepared with 6 concentrations of D. For each generation the DNA was analyzed, and its variability was established. The results showed a small involvement of D in the successive synthesis of nuclear DNA.
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"Characterization and Antibacterial Activity of Zinc Oxide Nanoparticles Synthesized from D. melanogaster." In 3rd INTERNATIONAL CONFERENCE ON BIOLOGICAL RESEARCH AND APPLIED SCIENCE. Jinnah University for Women, Karachi,Pakistan, 2023. http://dx.doi.org/10.37962/ibras/2023/23-26.

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Afanasyeva, K. P., A. N. Rusakovich, N. E. Kharchenko, I. D. Aleksandrov, and M. V. Aleksandrova. "GENOMIC CHANGES IN THE PROGENY OF DROSOPHILA MELANOGASTER MALES IRRADIATED BY y-RAYS." In SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-1-328-331.

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The results of sequencing and bioinformatics analysis of genomic changes in 9 F1 progeny of males from the isogenic line D. melanogaster irradiated by Co60 Y—rays at a dose of 40 Gy (LD85) and in 3 control samples are presented. In 9 progeny from irradiated males, a total of 46 genomic changes (32 significant and 15 mosaic de novo mutations) were found, which is equal to a frequency of 5.2 mutations/genome. The spectrum of changes included 33 deletions (17-78 000 bp in size), 4 duplications (322-1371 bp), 4 reciprocal translocations and 6 inversions in X, 2 and 3 chromosomes. In 3 studied cont
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Fouzat, Arij. "Elaeagnus Angustifolia extract inhabits cell invasion of human colorectal cancer cells and increases the survival rate of the Drosophila colon cancer model." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0103.

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Colorectal cancer (CRC), the third most common type of cancer in the world, is an aggressive type of cancer with high tendency to metastasize and invade to other tissues and distant organs. Traditional CRC treatment regimen includes 5-fluorouracil (5-FU); however, tumors develop a resistance against these drugs, apart from the severe side effects that develop upon these therapies. Nowadays, traditional medicinal plants are the focus of increased interest as a source for new potential drugs, particularly those that serve as anti-cancerous agents. Elaeagnus angustifolia (EA) is a medicinal plant
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Martin, Alberto, Leandro Murgas Saavedra, and Calixto Dominguez. "Development of a method for inferring regulatory networks of genes time and specific location: application and comparative studies in D. melanogaster." In MOL2NET 2016, International Conference on Multidisciplinary Sciences, 2nd edition. MDPI, 2016. http://dx.doi.org/10.3390/mol2net-02-17005.

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Yu, Congwei. "Visualizing age-specific daily activity levels and cohort survival in D. melanogaster:A minute-by-minute analysis." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.113926.

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Stenflo, J., A.-K. öhlin, Å. Lundvall та B. Dahlback. "β-HYDROXY ASPARTIC ACID AND ft-HYDROXYASPARAGINE IN THEEGF-HOMOLOGY REGIONS OF PROTEIN C AND PROTEINS". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643995.

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The amino acid sequence has been determined for all of the vitamin K-dependent proteins and the gene structure is known for some of them. These findings have shown the proteins to consist of four clearly discernible domains, except protein S which has six domains. The protein domains seem to be coded on separate exons (Foster, D. C. et. al. 1985 Proc. Natl. Acad. Sci. USA 82,4673). The vitamin K-dependent γ-carboxyglutamic acid (Gla) containing domain isthe common structural denominator of the members of this protein family. In addition, all of these proteins except prothrombin contain domains
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Reports on the topic "D. melanogaster"

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Applebaum, Shalom W., Lawrence I. Gilbert, and Daniel Segal. Biochemical and Molecular Analysis of Juvenile Hormone Synthesis and its Regulation in the Mediterranean Fruit Fly (Ceratitis capitata). United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570564.bard.

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Original Objectives and revisions: (1) "To determine the biosynthetic pathway of JHB3 in the adult C. capitata CA in order to establish parameters for the future choice and synthesis of suitable inhibitors". Modified: to determine the pattern of FR-7 biosynthesis during normal reproductive maturation, and identify enzymes potentially involved in its synthesis. (2) "To correlate allatal epoxidase activity to the biosynthesis of JHB3 at different stages of reproductive maturation/vitellogenesis and evaluate the hypothesis that a specific JH-epoxidase may be rate limiting". Modified: to study the
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Rafaeli, Ada, Russell Jurenka, and Daniel Segal. Isolation, Purification and Sequence Determination of Pheromonotropic-Receptors. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7695850.bard.

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Moths constitute a major group of pest insects in agriculture. Pheromone blends are utilised by a variety of moth species to attract conspecific mates, which is under circadian control by the neurohormone, PBAN (pheromone-biosynthesis-activating neuropeptide). Our working hypothesis was that, since the emission of sex-pheromone is necessary to attract a mate, then failure to produce and emit pheromone is a potential strategy for manipulating adult moth behavior. The project aimed at identifying, characterising and determining the sequence of specific receptors responsible for the interaction w
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Altstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7587235.bard.

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The general objective of this BARD project focused on rationally designed insect neuropeptide (NP) agonists and antagonists, their application for the characterization of the mechanisms of action of the pyrokinin/PBAN (PK-PBAN) family and the development of biostable, bioavailable versions that can provide the basis for development of novel, environmentally-friendly pest insect control agents. The specific objectives of the study, as originally proposed, were to: (i) Test stimulatory potencies of rationally designed backbone cyclic (BBC) peptides on pheromonotropic, melanotropic, myotropic and
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