Relevant bibliographies by topics / D1-class dopamine receptors

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'D1-class dopamine receptors'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 February 2022

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Journal articles on the topic "D1-class dopamine receptors"

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Ibañez-Sandoval, Osvaldo, Adán Hernández, Benjamin Florán, et al. "Control of the Subthalamic Innervation of Substantia Nigra Pars Reticulata by D1 and D2 Dopamine Receptors." Journal of Neurophysiology 95, no. 3 (2006): 1800–1811. http://dx.doi.org/10.1152/jn.01074.2005.

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The effects of activating dopaminergic D1 and D2 class receptors of the subthalamic projections that innervate the pars reticulata of the subtantia nigra (SNr) were explored in slices of the rat brain using the whole cell patch-clamp technique. Excitatory postsynaptic currents (EPSCs) that could be blocked by 6-cyano-7-nitroquinoxalene-2,3-dione and d-(−)-2-amino-5-phosphonopentanoic acid were evoked onto reticulata GABAergic projection neurons by local field stimulation inside the subthalamic nucleus in the presence of bicuculline. Bath application of ( RS)-2,3,4,5-tetrahydro-7,8-dihydroxy-1-
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Opazo, Juan C., Kattina Zavala, Soledad Miranda-Rottmann, and Roberto Araya. "Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD2l and DRD4rs dopamine receptor gene lineages." PeerJ 6 (April 13, 2018): e4593. http://dx.doi.org/10.7717/peerj.4593.

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Dopamine receptors are integral membrane proteins whose endogenous ligand is dopamine. They play a fundamental role in the central nervous system and dysfunction of dopaminergic neurotransmission is responsible for the generation of a variety of neuropsychiatric disorders. From an evolutionary standpoint, phylogenetic relationships among the DRD1 class of dopamine receptors are still a matter of debate as in the literature different tree topologies have been proposed. In contrast, phylogenetic relationships among the DRD2 group of receptors are well understood. Understanding the time of origin
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Amenta, Francesco, Livio Chiandussi, Maurizio Mancini, Alberto Ricci, Marina Schena, and Franco Veglio. "Pharmacological characterization and autoradiographic localization of dopamine receptors in the human adrenal cortex." European Journal of Endocrinology 131, no. 1 (1994): 91–96. http://dx.doi.org/10.1530/eje.0.1310091.

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Amenta F, Chiandussi L, Mancini M, Ricci A, Schena M, Veglio F. Pharmacological characterization and autoradiographic localization of dopamine receptors in the human adrenal cortex. Eur J Endocrinol 1994;131:91–6. ISSN 0804–4643 The pharmacological characteristics and the anatomical localization of dopamine D1-like and D2-like receptors were studied in sections of the human adrenal cortex using radioligand binding and autoradiographic techniques. [3H]SCH23390 was used as a ligand of D1-like receptors, whereas [3H]spiroperidol was used to label D2-like receptors. No specific [3H]SCH 23390 bindi
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Zackheim, J. A., and E. D. Abercrombie. "Decreased striatal dopamine efflux after intrastriatal application of benzazepine-class D1 agonists is not mediated via dopamine receptors." Brain Research Bulletin 54, no. 6 (2001): 603–7. http://dx.doi.org/10.1016/s0361-9230(01)00462-2.

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Moratalla, Rosario, Mario Vallejo, Bulent Elibol, and Ann M. Graybiel. "D1-class dopamine receptors influence cocaine-induced persistent expression of Fos-related proteins in striatum." NeuroReport 8, no. 1 (1996): 1–5. http://dx.doi.org/10.1097/00001756-199612200-00001.

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Shayegan, Darius K., and Stephen M. Stahl. "Atypical Antipsychotics: Matching Receptor Profile to Individual Patient's Clinical Profile." CNS Spectrums 9, S11 (2004): 6–14. http://dx.doi.org/10.1017/s1092852900025086.

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AbstractUnderstanding common pharmacologic and clinical “class” actions associated with atypical antipsychotics certainly reveals how these agents are alike, but what about unique differences from one agent to another? Atypical antipsychotics are also a heterogeneous group of agents that have complex pharmacologic entities, acting upon multiple dopamine receptors (D2, D1 (D3, and D4) and multiple serotonin receptors (5-HT2A, 5-HT2C, 5-HT1A, and 5-HT1D, among others). Atypical antipsychotics also interact with noradrenergic (α1- and α2-adrenergic receptor blockade), histaminergic (H1-receptor b
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Prommer, Eric. "Olanzapine." American Journal of Hospice and Palliative Medicine® 30, no. 1 (2012): 75–82. http://dx.doi.org/10.1177/1049909112441241.

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Olanzapine is an atypical antipsychotic agent of the thienobenzodiazepine class. Olanzapine blocks multiple neurotransmitter receptors, including dopaminergic (D1, D2, D3, and D4), serotonergic (5-hydroxytryptamine 2A [5-HT2A], 5-HT2C, 5-HT3, and 5-HT6), adrenergic (α1), histaminic (H1), and muscarinic (M1, M2, M3, and M4) receptors. Olanzapine has a high affinity for the 5HT2A receptor, which is up to 5 times greater than the dopamine receptor, resulting in less propensity to the development of extrapyramidal side effects. The affinity of olanzapine for multiple receptors has lead to the iden
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Omeljaniuk, Robert J. "Specific [3H]spiperone binding sites in the pituitary of rainbow trout (Oncorhynchus mykiss) and goldfish (Carassius auratus)." Canadian Journal of Physiology and Pharmacology 73, no. 5 (1995): 585–93. http://dx.doi.org/10.1139/y95-074.

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Dopamine, a catecholamine neurohormone, modulates pituitary hormone release in teleost fishes and other vertebrates. The existence and binding parameters of a pituitary dopamine–neuroleptic receptor from trout were examined and compared with those from goldfish. Pituitary homogenate was incubated with [3H]spiperone (D2 antagonist) under several experimental paradigms; incubations were terminated by filtration and bound 3H radioactivity was assessed by liquid scintillation spectroscopy. Specific binding of [3H]spiperone was tissue dependent. Equilibrium displacement analyses using domperidone (
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Hu, Xiu-Ti, and Francis J. White. "Dopamine enhances glutamate-induced excitation of rat striatal neurons by cooperative activation of D1 and D2 class receptors." Neuroscience Letters 224, no. 1 (1997): 61–65. http://dx.doi.org/10.1016/s0304-3940(97)13443-7.

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Dong, Yan, and Francis J. White. "Dopamine D1-Class Receptors Selectively Modulate a Slowly Inactivating Potassium Current in Rat Medial Prefrontal Cortex Pyramidal Neurons." Journal of Neuroscience 23, no. 7 (2003): 2686–95. http://dx.doi.org/10.1523/jneurosci.23-07-02686.2003.

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Dissertations / Theses on the topic "D1-class dopamine receptors"

1

Zhang, Boyang. "Functional and Structural Insights into the First and Second Intracellular Domains for D1-Class Dopaminergic Receptors." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35932.

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Previous studies have shown that the subtype-specific pharmacological properties of D1-class receptors (D1R and D5R) can be attributed to their third intracellular domain and C-terminal tail. However, the importance of their first and second intracellular domains (IC1 and IC2) has yet to be explored. Using mutagenesis and bioinformatics, we examine the functional and structural roles of Ser/Thr spanning IC1 and IC2—most of which are conserved not only among D1-class receptors but also among other GPCRs. Mutant receptors of human D1-class receptors (hD1R and hD5R) were constructed whereby all S
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Albaker, Awatif. "Mutational Analysis to Define the Functional Role of the Third Intracellular Loop of D1-Class Dopaminergic Receptors." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35063.

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The third intracellular loop (IL3) and cytoplasmic tail (CT), which are the most divergent regions between human D1-class dopaminergic receptors (hD1R and hD5R), have been implicated in modulating their subtype-specific functional phenotypes. The importance of the IL3 for Guanine nucleotide-binding protein (G-protein) coupling and specificity has long been acknowledged in the G-protein-coupled receptor (GPCR) field. However, the exact role the central region of the IL3, notably the N- and C-terminal moieties, plays in GPCR receptor functionality remains unclear. Studies in our laboratory indic
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Gower, Annette. "The Efficacy of Specific Activation of D1-class Dopamine Receptors to Enhance Motor Recovery in Mice Following Cortical Photothrombotic Stroke." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37619.

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Stroke is a widespread condition, which often leaves survivors with lasting deficits in motor function, however, physical rehabilitation is the only treatment available after the acute period. A large body of preclinical literature suggests dopamine-augmenting drugs, could enhance motor recovery following stroke. Unfortunately, mixed clinical results have prevented the implementation of such treatments, possibly due to the wide variety of G protein-coupled receptors these drugs can activate. Using a mouse photothrombosis stroke model and a battery of motor and sensorimotor behavioural tests, t
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Charrette, Andrew. "The Role of the Central Region of the Third Intracellular Loop of D1-Class Receptors in Signalling." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23080.

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The D1-class receptors (D1R, D5R) each possess distinct signaling characteristics; however, pharmacological selectivity between them remains elusive. The third intracellular loops (IL3) of D1R and D5R harbour divergent residues that may contribute to their individual signalling phenotypes. Here we probe the function of central region of IL3 of D1R and D5R using deletion mutagenesis. Radioligand binding and whole cell cAMP assays suggest that the N-terminal and C-terminal moieties of the central IL3 oppositely contribute to the constitutive and agonist-dependant activity of D1-Class receptors
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