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Journal articles on the topic 'D1-class dopamine receptors'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Ibañez-Sandoval, Osvaldo, Adán Hernández, Benjamin Florán, et al. "Control of the Subthalamic Innervation of Substantia Nigra Pars Reticulata by D1 and D2 Dopamine Receptors." Journal of Neurophysiology 95, no. 3 (2006): 1800–1811. http://dx.doi.org/10.1152/jn.01074.2005.

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The effects of activating dopaminergic D1 and D2 class receptors of the subthalamic projections that innervate the pars reticulata of the subtantia nigra (SNr) were explored in slices of the rat brain using the whole cell patch-clamp technique. Excitatory postsynaptic currents (EPSCs) that could be blocked by 6-cyano-7-nitroquinoxalene-2,3-dione and d-(−)-2-amino-5-phosphonopentanoic acid were evoked onto reticulata GABAergic projection neurons by local field stimulation inside the subthalamic nucleus in the presence of bicuculline. Bath application of ( RS)-2,3,4,5-tetrahydro-7,8-dihydroxy-1-

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2

Opazo, Juan C., Kattina Zavala, Soledad Miranda-Rottmann, and Roberto Araya. "Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD2l and DRD4rs dopamine receptor gene lineages." PeerJ 6 (April 13, 2018): e4593. http://dx.doi.org/10.7717/peerj.4593.

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Dopamine receptors are integral membrane proteins whose endogenous ligand is dopamine. They play a fundamental role in the central nervous system and dysfunction of dopaminergic neurotransmission is responsible for the generation of a variety of neuropsychiatric disorders. From an evolutionary standpoint, phylogenetic relationships among the DRD1 class of dopamine receptors are still a matter of debate as in the literature different tree topologies have been proposed. In contrast, phylogenetic relationships among the DRD2 group of receptors are well understood. Understanding the time of origin

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3

Amenta, Francesco, Livio Chiandussi, Maurizio Mancini, Alberto Ricci, Marina Schena, and Franco Veglio. "Pharmacological characterization and autoradiographic localization of dopamine receptors in the human adrenal cortex." European Journal of Endocrinology 131, no. 1 (1994): 91–96. http://dx.doi.org/10.1530/eje.0.1310091.

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Amenta F, Chiandussi L, Mancini M, Ricci A, Schena M, Veglio F. Pharmacological characterization and autoradiographic localization of dopamine receptors in the human adrenal cortex. Eur J Endocrinol 1994;131:91–6. ISSN 0804–4643 The pharmacological characteristics and the anatomical localization of dopamine D1-like and D2-like receptors were studied in sections of the human adrenal cortex using radioligand binding and autoradiographic techniques. [3H]SCH23390 was used as a ligand of D1-like receptors, whereas [3H]spiroperidol was used to label D2-like receptors. No specific [3H]SCH 23390 bindi

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4

Zackheim, J. A., and E. D. Abercrombie. "Decreased striatal dopamine efflux after intrastriatal application of benzazepine-class D1 agonists is not mediated via dopamine receptors." Brain Research Bulletin 54, no. 6 (2001): 603–7. http://dx.doi.org/10.1016/s0361-9230(01)00462-2.

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5

Moratalla, Rosario, Mario Vallejo, Bulent Elibol, and Ann M. Graybiel. "D1-class dopamine receptors influence cocaine-induced persistent expression of Fos-related proteins in striatum." NeuroReport 8, no. 1 (1996): 1–5. http://dx.doi.org/10.1097/00001756-199612200-00001.

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6

Shayegan, Darius K., and Stephen M. Stahl. "Atypical Antipsychotics: Matching Receptor Profile to Individual Patient's Clinical Profile." CNS Spectrums 9, S11 (2004): 6–14. http://dx.doi.org/10.1017/s1092852900025086.

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AbstractUnderstanding common pharmacologic and clinical “class” actions associated with atypical antipsychotics certainly reveals how these agents are alike, but what about unique differences from one agent to another? Atypical antipsychotics are also a heterogeneous group of agents that have complex pharmacologic entities, acting upon multiple dopamine receptors (D2, D1 (D3, and D4) and multiple serotonin receptors (5-HT2A, 5-HT2C, 5-HT1A, and 5-HT1D, among others). Atypical antipsychotics also interact with noradrenergic (α1- and α2-adrenergic receptor blockade), histaminergic (H1-receptor b

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7

Prommer, Eric. "Olanzapine." American Journal of Hospice and Palliative Medicine® 30, no. 1 (2012): 75–82. http://dx.doi.org/10.1177/1049909112441241.

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Olanzapine is an atypical antipsychotic agent of the thienobenzodiazepine class. Olanzapine blocks multiple neurotransmitter receptors, including dopaminergic (D1, D2, D3, and D4), serotonergic (5-hydroxytryptamine 2A [5-HT2A], 5-HT2C, 5-HT3, and 5-HT6), adrenergic (α1), histaminic (H1), and muscarinic (M1, M2, M3, and M4) receptors. Olanzapine has a high affinity for the 5HT2A receptor, which is up to 5 times greater than the dopamine receptor, resulting in less propensity to the development of extrapyramidal side effects. The affinity of olanzapine for multiple receptors has lead to the iden

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8

Omeljaniuk, Robert J. "Specific [3H]spiperone binding sites in the pituitary of rainbow trout (Oncorhynchus mykiss) and goldfish (Carassius auratus)." Canadian Journal of Physiology and Pharmacology 73, no. 5 (1995): 585–93. http://dx.doi.org/10.1139/y95-074.

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Dopamine, a catecholamine neurohormone, modulates pituitary hormone release in teleost fishes and other vertebrates. The existence and binding parameters of a pituitary dopamine–neuroleptic receptor from trout were examined and compared with those from goldfish. Pituitary homogenate was incubated with [3H]spiperone (D2 antagonist) under several experimental paradigms; incubations were terminated by filtration and bound 3H radioactivity was assessed by liquid scintillation spectroscopy. Specific binding of [3H]spiperone was tissue dependent. Equilibrium displacement analyses using domperidone (

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9

Hu, Xiu-Ti, and Francis J. White. "Dopamine enhances glutamate-induced excitation of rat striatal neurons by cooperative activation of D1 and D2 class receptors." Neuroscience Letters 224, no. 1 (1997): 61–65. http://dx.doi.org/10.1016/s0304-3940(97)13443-7.

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10

Dong, Yan, and Francis J. White. "Dopamine D1-Class Receptors Selectively Modulate a Slowly Inactivating Potassium Current in Rat Medial Prefrontal Cortex Pyramidal Neurons." Journal of Neuroscience 23, no. 7 (2003): 2686–95. http://dx.doi.org/10.1523/jneurosci.23-07-02686.2003.

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11

Mitrofanova, L. B., A. A. Perminova, N. S. Goncharova, and E. N. Mikhailov. "Histological and immunohistochemical study of nerve fibers and ganglia in the periarterial adipose tissue of the pulmonary artery bifurcation in patients with and without pulmonary hypertension." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 25, no. 5 (2020): 498–509. http://dx.doi.org/10.18705/1607-419x-2019-25-5-498-509.

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Background. One of the possible methods of reducing pressure in the pulmonary artery (PA) in pulmonary hypertension (PH) is radiofrequency damage of the periarterial nerve fibers. At the same time, the impact of the autonomic nervous system has not been fully determined yet. It is also known that dopamine induces LA vasorelaxation, however, the subtypes of dopamine receptors involved in this mechanism have not yet been identified.Objective. To assess the morphology of nerve fibers and ganglia in the periarterial adipose tissue of the PA bifurcation in patients with and without PH. Design and m

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12

Blandini, Fabio, Roberto Fancellu, Francesco Orzi, et al. "Selective stimulation of striatal dopamine receptors of the D1- or D2-class causes opposite changes of fos expression in the rat cerebral cortex." European Journal of Neuroscience 17, no. 4 (2003): 763–70. http://dx.doi.org/10.1046/j.1460-9568.2003.02520.x.

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13

Liu, Andrew M. F., Maurice K. C. Ho, Cecilia S. S. Wong, Jasmine H. P. Chan, Anson H. M. Pau та Yung H. Wong. "Gα 16/z Chimeras Efficiently Link a Wide Range of G Protein— Coupled Receptors to Calcium Mobilization". Journal of Biomolecular Screening 8, № 1 (2003): 39–49. http://dx.doi.org/10.1177/1087057102239665.

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G protein—coupled receptors (GPCRs) represent a class of important therapeutic targets for drug discovery. The integration of GPCRs into contemporary high-throughput functional assays is critically dependent on the presence of appropriate G proteins. Given that different GPCRs can discriminate against distinct G proteins, a universal G protein adapter is extremely desirable. In this report, the authors evaluated two highly promiscuous Gα16/z chimeras, 16z25 and 16z44, for their ability to translate GPCR activation into Ca2+ mobilization using the fluorescence imaging plate reader (FLIPR) and a

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14

Watanabe, Katsushige, and Minoru Kimura. "Dopamine Receptor–Mediated Mechanisms Involved in the Expression of Learned Activity of Primate Striatal Neurons." Journal of Neurophysiology 79, no. 5 (1998): 2568–80. http://dx.doi.org/10.1152/jn.1998.79.5.2568.

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Watanabe, Katsushige and Minoru Kimura. Dopamine receptor–mediated mechanisms involved in the expression of learned activity of primate striatal neurons. J. Neurophysiol. 79: 2568–2580, 1998. To understand the mechanisms by which basal ganglia neurons express acquired activities during and after behavioral learning, selective dopamine (DA) receptor antagonists were applied while recording the activity of striatal neurons in monkeys performing behavioral tasks. In experiment 1, a monkey was trained to associate a click sound with a drop of reward water. DA receptor antagonists were administered

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15

Fyfe, Tim J., Peter J. Scammells, J. Robert Lane, and Ben Capuano. "Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D1 Receptor." Molecules 26, no. 13 (2021): 3799. http://dx.doi.org/10.3390/molecules26133799.

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(1) Background: Two first-in-class racemic dopamine D1 receptor (D1R) positive allosteric modulator (PAM) chemotypes (1 and 2) were identified from a high-throughput screen. In particular, due to its selectivity for the D1R and reported lack of intrinsic activity, compound 2 shows promise as a starting point toward the development of small molecule allosteric modulators to ameliorate the cognitive deficits associated with some neuropsychiatric disease states; (2) Methods: Herein, we describe the enantioenrichment of optical isomers of 2 using chiral auxiliaries derived from (R)- and (S)-3-hydr

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16

Vanover, Kimberly, Steven Glass, Susan Kozauer, et al. "30 Lumateperone (ITI-007) for the Treatment of Schizophrenia: Overview of Placebo-Controlled Clinical Trials and an Open-label Safety Switching Study." CNS Spectrums 24, no. 1 (2019): 190–91. http://dx.doi.org/10.1017/s1092852919000245.

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AbstractBackgroundLumateperone is a first-in-class agent in development for schizophrenia that acts synergistically through serotonergic, dopaminergic and glutamatergic systems. Lumateperone is a potent 5-HT2A antagonist, a mesolimbic/mesocortical dopamine phosphoprotein modulator (DPPM) with pre-synaptic partial agonist and post-synaptic antagonist activity at D2, a glutamate GluN2B receptor phosphoprotein modulator with D1-dependent enhancement of both NMDA and AMPA currents via the mTOR protein pathway and an inhibitor of serotonin reuptake.MethodsLumateperone was evaluated in 3 controlled

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17

Sun, Bingfa, Dan Feng, Matthew Ling-Hon Chu, et al. "Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist." Nature Communications 12, no. 1 (2021). http://dx.doi.org/10.1038/s41467-021-23519-9.

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AbstractDopamine D1 receptor (D1R) is an important drug target implicated in many psychiatric and neurological disorders. Selective agonism of D1R are sought to be the therapeutic strategy for these disorders. Most selective D1R agonists share a dopamine-like catechol moiety in their molecular structure, and their therapeutic potential is therefore limited by poor pharmacological properties in vivo. Recently, a class of non-catechol D1R selective agonists with a distinct scaffold and pharmacological properties were reported. Here, we report the crystal structure of D1R in complex with stimulat

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18

Feng, Jian. "Modeling the pathophysiology of Parkinson’s disease in patient-specific neurons." Experimental Biology and Medicine, September 24, 2020, 153537022096178. http://dx.doi.org/10.1177/1535370220961788.

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The 30 trillion cells that self-assemble into a human being originate from the pluripotent stem cells in the inner cell mass of a human blastocyst. The discovery of induced pluripotent stem cells (iPSCs) makes it possible to approximate various aspects of this natural developmental process artificially by generating materials that can be used in invasive mechanistic studies of virtually all human conditions. In Parkinson’s disease, instructions computed by the basal ganglia to control voluntary motor functions break down, leading to widespread rhythmic bursting activities in the basal ganglia

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