Relevant bibliographies by topics / D14

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Academic literature on the topic 'D14'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "D14"

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Fernandes, Juliano José R., Lorena E. L. M. Bomfim, Daniel Augusto A. Teixeira, Victor R. M. Couto, and Ana Laura A. Lopes. "PSXII-38 Effect of crude protein sources on feedlot performance and carcass traits of Nellore young bulls." Journal of Animal Science 97, Supplement_3 (December 2019): 426. http://dx.doi.org/10.1093/jas/skz258.845.

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Abstract In this trial, 120 Nellore young bulls of ± 386kg kg initial weight were used to evaluate the effect of different sources of crude protein on the feedlot performance (finishing phase) and carcass characteristics. Animals were maintained in fifteen pens for 105 days. Animals were individually weighed and blocked by initial body weight. Pens within a block were randomly assigned to one of three treatments: (D14) Control diet including 14% of crude protein (CP) on dry matter; (D12) Inclusion of 12.5% CP/dry matter and (D11), inclusion of 11% of CP/dry matter. Feed offered was monitored daily as well as feed refusals were collected and weighed to determine the DMI and feed efficiency (F:G). Animals were weighed every 28 d after 16 h feed withdrawal for calculating ADG. The D14 and D12 treatments increased the final weight (P = 0.008) when compared to D11 (564.13; 550.96 and 529.73 kg, respectively). The D14 treatment increased the ADG (1.69 kg; P = 0.002) when compared to D12 (1.54 kg) and D11 animals (1.35 kg). The same was observed for DMI (P = 0.001) (10.40kg, 9.77kg e 8.68kg, respectively) and % BW (P = 0.001), when D14 had the greatest value (2.2%), and D11 the worst (1.90%). There were no effect of the treatments for F:G (P = 0.202). Hot carcass weight was increased by the D14 treatment (P = 0.006) (311.97kg; 300.55 and 289.30kg, respectively). However, the cooling losses were not affected (P = 0.0843), as well as were observed for dressing (P = 0.089). Nevertheless, the carcass daily gain was improved by the D14 (P = 0.02), with animals increasing 1.13 kg/d; D12 with 1.01kg/d and D11, 0.91 kg. In conclusion, the sources of crude protein can affect the feedlot cattle performance, in agreement with the Brazilian Nellore requirement program (Br-Corte). However, in this trial, diets with 14% of CP improved the animal’s performance.
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Banek, Christopher T., Ashley J. Bauer, Anne Gingery, and Jeffrey S. Gilbert. "Timing of ischemic insult alters fetal growth trajectory, maternal angiogenic balance, and markers of renal oxidative stress in the pregnant rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 303, no. 6 (September 15, 2012): R658—R664. http://dx.doi.org/10.1152/ajpregu.00250.2012.

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Increased uterine artery resistance and angiogenic imbalance characterized by increased soluble fms-like tyrosine kinase-1 (sFlt-1) and decreased free vascular endothelial growth factor (VEGF) are often associated with placental insufficiency and preeclampsia but not synonymous with hypertension. We hypothesized chronic reductions in utero-placental perfusion (RUPP) for 5 days (d) during either mid- (d12–d17) or late (d14–d19) gestation would have disparate effects on plasma sFlt-1 and VEGF levels and blood pressure. Five days of chronic RUPP was achieved by placement of silver clips on the abdominal aorta and ovarian arteries on either gestational d12 or d14. Arterial pressure was increased ( P < 0.05) in RUPP vs. normal pregnant (NP) in both d17 (10%) and d19 (25%) groups, respectively. Circulating free VEGF was decreased ( P < 0.05) and sFlt-1:VEGF ratio increased ( P < 0.05) after 5 days of RUPP ending on d19 but not d17 compared with NP controls. Angiogenic imbalance, measured by an endothelial tube formation assay, was present in the d19 RUPP but not the d17 RUPP compared with age-matched NP rats. Five days of RUPP from days 14 to 19 decreased fetal and placental weights 10% ( P < 0.01) compared with d19 NP controls. After 5 days of RUPP, from days 12 to 17 of pregnancy, fetal weights were 21% lighter ( P < 0.01) compared with d17 NP controls, but placental weight was unchanged. These findings suggest that the timing during which placental insufficiency occurs may play an important role in determining the extent of alterations in angiogenic balance, fetal growth restriction, and the severity of placental ischemia-induced hypertension.
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Liu, Dongxia, Qingrui Yang, Ming Li, Kun Mu, and Yuanchao Zhang. "Association of an asporin repeat polymorphism with ankylosing spondylitis in Han Chinese Population: A case-control study." Clinical & Investigative Medicine 33, no. 1 (February 1, 2010): 63. http://dx.doi.org/10.25011/cim.v33i1.11839.

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Objective: To investigate the role of a functional polymorphism consisting of an aspartic acid (D) repeat located in the asporin gene (ASPN) gene in the susceptibility to and clinical outcome of ankylosing spondylitis (AS). Methods: A total of 374 Chinese patients with ankylosing spondylitis and 421 controls of the same ethnic origin matched for age and sex were included in the study. The asporin D repeat polymorphism was genotyped by polymerase chain reaction with a fluorescent primer. Results: Significant differences between AS patients and controls were detected in the distribution of the 7 alleles found in our population. D14 and D16 alleles were significantly over-represented in AS patients (D14, P=0.001, odds ratio (OR)=1.857, 95% confidence interval(CI) 1.27-2.715; and D16, P < 0.0001, OR=2.605, 95% CI 1.75-3.879). D16 over-representation was more common in early-onset patients than in late-onset patients, although the difference did not reach significance (P= 0.071). Conclusion: The results support a role for an asporin D repeat polymorphism in the susceptibility to AS and an influence of this gene on the outcome of the disease. D14 and D16 allele variants of ASPN might be the susceptibility alleles for AS in the Han Chinese population, whereas the D13 allele variant may have a protective effect on the onset of AS.
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Brito dos Santos, Susana, Mark C. Allenby, Athanasios Mantalaris, and Nicki Panoskaltsis. "Early Erythroid Development Is Enhanced with Hypoxia and Terminal Maturation with Normoxia in a 3D Ex Vivo Physiologic Eythropoiesis Model." Blood 128, no. 22 (December 2, 2016): 2453. http://dx.doi.org/10.1182/blood.v128.22.2453.2453.

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Abstract Reproduction of dynamic physiologic erythropoiesis in vitro requires a three-dimensional (3D) architecture, erythroblast-macrophage interactions and cytokines such as erythropoietin (EPO). The role of oxygen concentration gradients in this process is unclear. We have created a 3D bone marrow (BM) biomimicry using collagen-coated polyurethane scaffolds (5mm3) to expand cord blood mononuclear cells (CBMNCs) in a cytokine-free environment for 28 days (D). Addition of EPO to this system induces mature erythropoiesis. We hypothesised that physiologic concentrations of cytokines - stem cell factor (SCF) / EPO - and a hypoxia (H)/normoxia (N) schedule to mimic BM oxygen gradients would enhance erythropoiesis. CBMNCs were seeded (4x106 cells/scaffold) in 3D serum-free cultures supplemented with 10ng/mL SCF (D0-D28), and 100mU/mL EPO (D7-D28), with medium exchange every 3D. Three conditions were compared: N (20%), H (5%) and 2-step oxygenation HN (H D0-D7 and N thereafter). Erythroid maturation was monitored weekly by flow cytometry (CD45/CD71/CD235a) both in situ (i.e., in scaffolds) and in supernatant (S/N) cells. D0-7 H was more efficient in early induction of CD235a in the absence of exogenous EPO (H 13% vs N 8% CD45loCD71+CD235alo cells, p<0.05). This maturation profile was also observed in D10 S/N cells, in which CD45loCD71+CD235a+ cells were proportionately more in H (30%) and HN (27%) than in N (16%, p<0.05). By D14, N and HN stimulated the appearance of CD45-CD71+CD235a+ cells, whereas H maintained the CD45loCD71+CD235a-/lo phenotype. By D21, a CD45-CD71+CD235a+ mature population was clearly distinguished in all conditions, most notably in N (16%) and HN (21%) vs H (9%). At D28, more mature CD45-CD71loCD235a+ cells were observed in normoxia conditions, N 3% and HN 4%, vs H 0.3%. A renewed population of erythroid progenitors was also evident at this time (H 62%, N 51% and HN 46% CD45loCD71lo/+CD235a- cells). In order to assess the impact of H and N on erythroid gene transcription, we evaluated erythroid signatures by qRT-PCR. GATA-1 expression was detected from D7, highest for H at D14 (p<0.05), and decreased thereafter. GATA-2 expression was up-regulated only at D28, in particular in N (p<0.05), and correlated with emerging erythroid progenitors identified at this stage. At D14, EPOR expression was maximal, especially in HN (p<0.05), simultaneous with high pSTAT5 levels, suggesting activation of EPOR signalling. Also at D14, H upregulated γ-globin (p<0.05). By Western Blot, only H and HN still produced γ-globin whereas β-globin expression was clearly detected in all conditions by D28. In situ production of cytokines was evaluated by cytometric bead array in the exhausted media. IL-6, G-CSF, GM-CSF, IL-1, TNF-α and IL-17 were detected at higher concentrations during the first 7 days, declining to undetectable thereafter. IL-21 was not detected at any point. IL-3 was detected from D13, with highest expression in H (p<0.05, D22). VEGF was also expressed after D7, highest in H (p<0.05, D16 & D19), concurrent with HIF-1α up-regulation observed at D7 and D14. TNF-α was produced with variable intensity from D4. These data suggested that D7-D14 was a crucial period for culture dynamics, in particular for H and HN, with up-regulation of erythroid transcription factors, EPOR signalling, and endogenous cytokine production. BFU-E and CFU-E also dominated the first 14 days of culture. Scanning electron microscopy at D17 and D25 revealed niche-like structures in situ, which expressed STRO-1, osteopontin and vimentin at D19 by confocal immunofluorescent microscopy, indicative of an endogenous stromal cell microenvironment. CD68+ cells were also detected at D19 in proximity to CD71+ cells suggesting formation of erythroblastic islands. In this 3D ex vivo biomimicry using near-physiologic cytokine and oxygen conditions, H induced initial erythroid commitment and established an early erythroid progenitor population. N was required at later maturational stages and enhanced the γ-globin to β-globin switch. We identified D7-D14 as a crucial timeframe in this system wherein endogenous cytokine production as well as up-regulation of GATA-1, EPOR and HIF-1α was observed. We propose that a combined HN schedule in this 3D BM biomimicy may enable a more robust and physiologic culture platform to study normal and abnormal erythroid differentiation. Disclosures No relevant conflicts of interest to declare.
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Mason, Emily F., Olga Pozdnyakova, Mikhail Roshal, Amir T. Fathi, Eytan M. Stein, Aaron C. Shaver, Mark G. Frattini, et al. "Bone Marrow Morphologic Findings in Patients Receiving IDH Inhibitor Therapy in Combination with Intensive Induction Chemotherapy: Challenges with Interpretation of the Day 14 Bone Marrow Biopsy." Blood 134, Supplement_1 (November 13, 2019): 1442. http://dx.doi.org/10.1182/blood-2019-123845.

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Background: Ivosidenib (Ivo) and enasidenib (Ena) are potent, mutant-specific oral inhibitors of the IDH1 and IDH2 proteins, respectively, and are approved as single agents for the treatment of newly diagnosed (Ivo) and/or relapsed/refractory (Ivo and Ena) AML. When used as single agents, these inhibitors induce differentiation of leukemic blasts, often without a period of bone marrow (BM) aplasia (PMID 28588020, 29860938). A phase 1 study (NCT02632708) examining the safety and efficacy of Ivo or Ena in combination with intensive induction chemotherapy (IDHi/7+3) in newly diagnosed AML with mutant IDH1 or IDH2 (mIDH) has yielded encouraging response rates in preliminary reports (Stein et al. ASH 2018; Abstract 560). The effect of IDHi/7+3 on BM morphology and whether features of differentiation are seen in this context is unknown. Here, we report the clinicopathologic findings in a cohort of patients treated with IDHi/7+3 and describe a distinct pattern of BM response with implications for post-therapy disease monitoring. Methods: Investigators from participating sites for NCT02632708 were invited to contribute cases. 36 patients from 4 sites were included with IRB approval at all sites. For each patient, the diagnostic BM biopsy and aspirate smear (BMBx) and all subsequent BMBx performed until end of induction (EOI) or removal from study were reviewed at individual sites based on consensus criteria. A subset of cases was re-reviewed by all pathologists via photomicrographs and digital whole slide images. Patients were categorized into 3 groups based on their Day 14 (D14) BMBx: 1) Aplasia (D14A = &lt;10% cellular; and &lt;5% blasts); 2) Differentiation (D14D = &gt;10% cellular; and &gt;5% blasts at D14; with morphologic or flow cytometric evidence of blast differentiation at D14 or D21); or 3) Persistent AML (D14P = &gt;10% cellular; and &gt;5% blasts; and no differentiation or clearance of blasts at D14 or later time points). Clinicopathologic data was collected from the electronic medical record and from the study database. IDH mutation clearance (MC) was defined as a reduction in the mIDH variant allele frequency in BM mononuclear cells to a level below the limit of detection of the assay (0.02-0.04%) for ≥1 on-treatment time point on or after D28 of induction. Results: The cohort included 17 mIDH1 patients who received Ivo and 19 mIDH2 patients who received Ena (Table 1, Fig 1); 1 patient in each treatment group had mIDH1 and mIDH2. In the 31 patients evaluable for response at EOI, 27 achieved CR or CRi/p; 2 MLFS; and 2 SD. Of 29 patients with a morphologic response (CR, CRi/p, MLFS), 19 (66%) were classified as D14A (median 5% cellularity; median &lt;5% blasts). Conversely, 10/29 patients (34%) exhibited D14D, with elevated BM cellularity (median 20% [10%, 20%]) and increased BM blast percentage (median 45% [5%, 80%]). In these cases, granulocytic and/or monocytic differentiation (Fig. 2) was most commonly seen at D14 (8/10) but emerged at D21 for 2/10 patients. Strikingly, despite the elevated cellularity and blast percentages at D14, 7/10 D14D patients subsequently achieved CR/CRi/p by D42 post-induction in the absence of additional intensive therapy; the remaining 3 patients achieved CR/CRi/p after a second cycle of induction. Of the 5 patients not evaluable at EOI, 3 had D14A and 2 had D14P. The 4/36 patients with D14P had a median BM cellularity of 27.5% and a median blast percentage of 33.5% at D14 with no evidence of differentiation. Differentiation was more common in patients treated with Ena (7/19 [36.8%]) than patients receiving Ivo (3/17 [17.6%]) and was seen in 4 of 6 patients with an IDH2R172 mutation. Only 1 of 8 patients with a co-occurring NPM1 mutation showed blast differentiation. Similar rates of IDH MC were seen in patients with D14A (4/22) and D14D (2/10). Conclusions: We describe here a distinct pattern of BM response, with delayed blast clearance and evidence of leukemic cell differentiation, in mIDH AML patients treated with IDHi/7+3. Our data suggest that patients with relatively high BMBx cellularity and residual blasts at D14 post-induction, even in the absence of evidence of differentiation at D14, should not be considered as induction failures and should be reassessed at later timepoints before being considered for additional induction therapy. Misinterpretation of D14 BMBx may ultimately lead to unnecessary therapy given that a significant subset of patients has an atypical BM response. Figure Disclosures Mason: Sysmex: Honoraria. Pozdnyakova:Sysmex corporation of America: Research Funding. Roshal:Celgene: Other: Provision of Services; Auron Therapeutics: Equity Ownership, Other: Provision of services; Physicians' Education Resource: Other: Provision of services. Fathi:Agios, Astellas, Celgene, Daiichi Sankyo, Novartis, Takeda, Amphivena, Kite, Forty Seven,Trovagene, NewLink genetics, Jazz, Abbvie, and PTC Therapeutics: Consultancy; Amphivena, Kite, Jazz, NewLink Genetics,: Honoraria. Stein:Novartis: Membership on an entity's Board of Directors or advisory committees; PTC Therapeutics: Membership on an entity's Board of Directors or advisory committees; Agios: Consultancy, Membership on an entity's Board of Directors or advisory committees; Genentech: Membership on an entity's Board of Directors or advisory committees; Daiichi Sankyo, Inc.: Membership on an entity's Board of Directors or advisory committees; Astellas Pharma US, Inc: Membership on an entity's Board of Directors or advisory committees; Celgene Corporation: Membership on an entity's Board of Directors or advisory committees; Syros: Membership on an entity's Board of Directors or advisory committees; Bioline: Membership on an entity's Board of Directors or advisory committees. Frattini:Celgene Corporation: Employment, Equity Ownership. Wang:Agios: Employment, Equity Ownership. Hua:Agios Pharmaceuticals, Inc.: Employment, Equity Ownership. Mu:Agios Pharmaceuticals, Inc.: Employment. Almon:Agios Pharmaceuticals: Employment, Equity Ownership. Cooper:Agios: Employment, Equity Ownership. Stone:AbbVie, Actinium, Agios, Argenx, Arog, Astellas, AstraZeneca, Biolinerx, Celgene, Cornerstone Biopharma, Fujifilm, Jazz Pharmaceuticals, Amgen, Ono, Orsenix, Otsuka, Merck, Novartis, Pfizer, Sumitomo, Trovagene: Consultancy; Argenx, Celgene, Takeda Oncology: Other: Data and Safety Monitoring Board/Committee: ; Novartis, Agios, Arog: Research Funding. Hasserjian:Jazz Pharmaceuticals: Consultancy; Promedior, Inc.: Consultancy. Savona:TG Therapeutics: Membership on an entity's Board of Directors or advisory committees, Research Funding; Sunesis: Research Funding; AbbVie: Membership on an entity's Board of Directors or advisory committees; Karyopharm Therapeutics: Consultancy, Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Boehringer Ingelheim: Patents & Royalties; Celgene Corporation: Membership on an entity's Board of Directors or advisory committees; Selvita: Membership on an entity's Board of Directors or advisory committees; Takeda: Membership on an entity's Board of Directors or advisory committees, Research Funding; Incyte Corporation: Membership on an entity's Board of Directors or advisory committees, Research Funding. OffLabel Disclosure: Ivosidenib and enasidenib are mutant-specific oral inhibitors of the IDH1 and IDH2 proteins, respectively, approved as single agents for the treatment of AML. This study will discuss their use in combination with intensive induction chemotherapy for the treatment of AML.
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Kardinaal, Alwine, Min Young Park, Jong Eun Jeon, Hee Jung Choi, Ji Yeon Kim, Oran Kwon, Els van Hoffen, and Anita Hartog. "Oral Cholera Vaccination as a Model to Assess Dietary Modulation of Gut Inflammation and Immunity." Current Developments in Nutrition 5, Supplement_2 (June 2021): 1129. http://dx.doi.org/10.1093/cdn/nzab061_013.

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Abstract Objectives The aim was to develop a human challenge model in which modulation of immune and inflammatory response by food ingredients can be evaluated. We hypothesized that oral cholera vaccination, in addition to inducing a specific antibody response, induces a significant increase in gut inflammatory response. Methods Twenty healthy men (age 30.6 ± 1.8 y; BMI 24.9 ± 0.6) were enrolled in the study. Fecal and blood samples were collected at baseline. After a 2-week run-in period (D0-D14), subjects were vaccinated with oral cholera vaccine Dukoral (D15). After a period of 2 weeks, a second vaccination was administered (D29). Fecal samples were collected the day before (D14; D28) and the days (D16/D17; D30/D31) after each vaccination, as well as on D42. Blood samples were collected before vaccination (D15; D29), and on D16 and D17/D31, on D43. Primary outcome was fecal calprotectin concentration, secondary outcomes were serum levels of cholera toxin (CTB)-specific IgA and IgG. Other markers of local and systemic inflammatory response included beta-defensins, IP-10, IL-1 ra and hsCRP. Changes over time were tested by means of a linear mixed model. Outliers were identified with the 1.5xIQR rule and excluded from analysis. Results Fecal calprotectin did not increase after the first vaccination. After the second vaccination, a significant increase was observed: from 12.8 ± 2.5 μg/g feces (mean ± SEM) on day 29 to 18.0 ± 2.9 μg/g on day 31 (P = 0.017). Plasma CTB-specific IgA and IgG were strongly increased after the first vaccination, with a further increase after the second vaccination. Plasma CRP slightly decreased on D17, compared to D15 (P = 0.016). IL-1ra significantly decreased 2 days after the first vaccination (P = 0.011), whereas no change was observed after the second vaccination. Beta-defensin was significantly increased at D31 compared to D29 (from 42.7 ± 7.0 to 80.7 ± 16.1 (P = 0.014)). IP-10 did not show any response to vaccination. Conclusions In addition to the expected antibody response, oral cholera vaccination induces an increase in fecal calprotectin and beta defensin, pointing to vaccine induced intestinal inflammation. These readouts may be added to intervention studies with dietary compounds to evaluate the potential for modulating immune responsiveness. Funding Sources Bio&Medical Technol Developm Program of the Natl Res Foundation, Min Science & ICT of Rep Korea.
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Tarantelli, Chiara, Eugenio Gaudio, Petra Hillmann, Filippo Spriano, Ivo Kwee, Andrea Rinaldi, Anastasios Stathis, et al. "Targeting the PI3K/mTOR Pathway in Lymphoma with PQR309 and PQR620: Single Agent Activity and Synergism with the BCL2 Inhibitor Venetoclax." Blood 128, no. 22 (December 2, 2016): 3017. http://dx.doi.org/10.1182/blood.v128.22.3017.3017.

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Abstract Background. The PI3K/AKT/mTOR pathway is an important therapeutic target in lymphomas. PQR309 is a dual PI3K/mTOR inhibitor that has shown in vitroanti-lymphoma activity (Tarantelli et al, ASH2015) and is in phase 2 trial (NCT02249429, , NCT02723877, NCT02669511). PQR620 is a novel mTORC1/2 inhibitor that has shown preclinical activity in solid tumor models (Beaufils et al, AACR 2016). Here, we present the in vitro and in vivo anti-lymphoma activity of PQR620 as single agent and also the in vivo results of PQR620 or PQR309 containing combinations with the BCL2 inhibitor venetoclax. Materials and Methods. The drug concentration causing 50% inhibition of cell proliferation (IC50) was obtained in lymphoma cell lines [diffuse large B cell lymphoma (DLBCL), no.=26; mantle cell lymphoma (MCL), no.=8; anaplastic large T-cell lymphoma, no.=5; others, no=5] exposed to increasing doses of PQR620 for 72h using a Tecan D300e Digital Dispenser on 384well plates. For in vivo experiments, NOD-Scid (NOD.CB17-Prkdcscid/J) mice were subcutaneously inoculated with 10 x106 (RIVA) or with 5 x106(SU-DHL-6) cells. Results. PQR620 had a median IC50 of 250 nM (95%CI, 200-269 nM) when tested on 44 lymphoma cell lines. Activity was higher in B cell (no.=36) than in T cell tumors (no.=8) (median IC50s: 250 nM vs 450 nM; P=0.002). At 72h, anti-tumor activityof PQR620 was mostly cytostatic and apoptosis induction was seen only in 6/44 cell lines (13%), Sensitivity to PQR620 or apoptosis induction did not differ between DLBCL and MCL, and they were not affected by the DLBCL cell of origin, by TP53 status or by the presence of MYC or BCL2 translocations. The activity of PQR620 as single agent underwent in vivo evaluation in two DLBCL models, the germinal center B cell type DLBCL (GCB-DLBCL) SU-DHL-6 and the acivated B cell-like DLBCL (ABC-DLBCL) RIVA. Treatments with PQR620 (100mg/kg dose per day, Qdx7/w) started with 100-150 mm3 tumors and were carried for 14 (SU-DHL-6) or 21 days (RIVA). In both models, PQR620 determined a 2-fold decrease of the tumor volumes in comparison with control, with significant differences in both SU-DHL-6 (D7, D9, D11, D14; P < 0.005) and RIVA (D14, D16, D19, D21; P < 0.005). Based on the previously reported synergy between the dual PI3K/mTOR inhibitor PQR309 and venetoclax (Tarantelli et al, ASH 2015), we evaluated the combination of the PQR620 or PQR309 with the BCL2 inhibitor venetoclax (100 mg/kg, Qdx7/w) in the SU-DHL-6 model. Both the venetoclax combination with the dual PI3K/mTOR inhibitor and the venetoclax combination with mTORC1/2 inhibitor were superior to the compounds given as single agents, leading to the eradication of the xenografts. The combination of PQR620 with venetoclax showed highly significant differences either versus control or single agents during all days of the experiment (D4, D7, D9, D11, D14; P < 0.001). Similarly, the combination of PQR309 with venetoclax showed highly significant differences versus venetoclax (D7, D9, D11, D14; P < 0.001) and PQR309 (D7, D9, D11; P < 0.005) alone. Conclusions. The novel mTORC1/2 inhibitor PQR620 had in vitro and in vivo anti-lymphoma activity as single agent. In vivo experiments showed that both PQR620 and the dual PI3K/mTOR inhibitor PQR309 can strongly benefit from the combination with the BCL2 inhibitor venetoclax. Disclosures Hillmann: PIQUR Therapeutics AG: Employment. Fabbro:PIQUR Therapeutics AG: Employment. Cmiljanovic:PIQUR Therapeutics AG: Employment, Membership on an entity's Board of Directors or advisory committees.
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El-Hamshary, Ola IM, Sarah K. Abdullah, and NH Al-Twaty. "Molecular Characterization and Biofilm Formation Study of Contaminant Bacteria Isolated from Domiaty and Hungarian Cheeses in Jeddah City." Journal of Pure and Applied Microbiology 15, no. 2 (June 1, 2021): 983–97. http://dx.doi.org/10.22207/jpam.15.2.57.

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The aim was to study the microbiological quality of Domiaty and Hungarian cheeses, molecular identification and biofilm formation of some selected contaminant bacteria. Samples were collected from two M and P big markets in Jeddah City through the period from February to October 2018, nine visits for two types of natural cheese. Results showed that the total bacterial counts (CFU/ml) from Domiaty cheese from two markets (M and P) were 0.1 x 105, 8 x 105 and 1 x 10 5 CFU/ml respectively (3 visits of M market) and 4 x 106, 0.4 x 106, 6.5 x 103, 1 x 103, 0.1 x 103 and 0.1 x 103 CFU/ml respectively (six samples from 6 visits from P market). Results showed that the total bacterial counts (CFU/ml) from Hungarian cheese were 1.5 x 10 5, 1x 10 4, 11 x 10 4 and 4 x10 6 CFU/ml respectively from (4 visits of M market) and 0.18 x 104, 3 x 106, 22 x 106, 6 x 106 and 5 x 104 CFU/ml respectively (5 visits from P market).Different bacterial isolates from cheese were identified by morphology and biochemical test. Bacterial isolates from cheeses were identified by VITEK MS as follow: Serratia liquefaciens (D6-1, D6-2, D14-1, D13-1 and D13-2), and Pseudomonas fluorescens (D14-2) were isolated from Domiaty cheese while Enterococcus faecium (H11-2), Serratia liquefaciens (H15-1) and Streptococcus thermophilus (H14-1) were isolated from Hungarian cheese. Some selected bacterial isolates were identified by 16S rRNA. Isolates were belong to MK757978 (Raoultilla terrigena (D15-1)), MK757979 (Bacillus cereus (D16-1)), MK757980 (Enterococcus faecalis (H10-2)), MK757982 (Enterococcus fiscalism (H11-1)), MK757981 (Serratia liquefactions (H13-1)), MK757984 (Anoxybacillus flavithermus (H17-1). All bacterial isolates have been tested for the formation of biofilm using a Tissue Culture Plate (TCP). Results revealed 12.5% and 46.15% of high biofilm formation respectively for bacterial isolates of Domiaty and Hungarian cheeses.
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Pinjisakikool, Teerapong. "The Influence of Personality Traits on Households’ Financial Risk Tolerance and Financial Behaviour." Journal of Interdisciplinary Economics 30, no. 1 (November 9, 2017): 32–54. http://dx.doi.org/10.1177/0260107917731034.

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Using a large sample that can represent the Dutch population, this article mainly studies the determinants of financial risk tolerance. I propose that the big five personality traits are the potential factors that can explain differences in financial risk tolerance among individuals. Furthermore, this article examines the effect of personality traits on the actual financial behaviour of households through financial risk tolerance. I find that all the big five personality traits including extraversion, agreeableness, conscientiousness, emotional stability and intellect significantly predict financial risk tolerance. Additionally, these personality traits as instrumental variables can also indirectly predict the financial behaviour of households. JEL: D10, D14, D19
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Karutz, M., and G. Soldner. "Einleitung / Stannum metallicum (ext.) / Plumbum D14, 2 Teile / Stannum D14, 1 Teil und Plumbum D14, 1 Teil / Stannum D14, 2 Teile." Der Merkurstab 69, no. 1 (2016): 37–41. http://dx.doi.org/10.14271/dms-20589-de.

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Dissertations / Theses on the topic "D14"

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Summers, William. "D14-LIKE : an essential protein for the establishment of arbuscular mycorrhizal symbiosis." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288351.

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Low nutrition availability in the soil can be a major limitation of plant growth. To improve nutrient acquisition, the majority of land plants engage in symbiosis with arbuscular mycorrhizal (AM) fungi. The accommodation of fungal colonisation structures in the roots requires their radical reprogramming. This starts during pre-symbiotic communication, where signals are exchanged between the fungus and plant across the rhizosphere. The receptor D14-LIKE emerged as a vital component of this pre-symbiotic communication when it was found to be absolutely required for symbiosis in rice. However, the broader relevance of the receptor, both in terms of functional conservation across plant species and its relation to other pre-symbiotic plant signalling components, remained unclear. The aim of this thesis was to elucidate these two key points. To address the fragmented picture of fungal signals, plant receptors and signalling pathways, a large scale transcriptomic experiment in rice was conducted to tie D14L together with other distinct pre-symbiotic components. In the absence of D14L-mediated signalling, rice was found to be compromised in the perception of germinated spore exudates, as well as specific chitinaceous signals, meaning that normal transcriptional reprogramming could not be achieved in response to any of these treatments. In addition, the functional conservation of D14L signalling was explored using trans-species complementation experiments. It was found that the Arabidopsis homolog AtKAI2 could complement the developmental phenotype of the d14l rice mutant, but not symbiosis. Likewise, D14La from early diverging Marchantia polymorpha and Marachantia paleacea could rescue developmental phenotypes in d14l rice, but again failed to complement symbiosis. This demonstrated a functional separation between developmental and symbiotic signalling. The data generated during my PhD foster D14L as a central node for multiple inputs to pre-symbiotic reprogramming, and provides new insights into pre-symbiotic communication mechanisms which are required for the successful establishment of symbiosis.
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Feldkircher, Martin, Philipp Poyntner, and Helene Schuberth. "Effects of the ECB's Unconventional Monetary Policy on Real and Financial Wealth." WU Vienna University of Economics and Business, 2019. http://epub.wu.ac.at/7040/1/WP286.pdf.

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We assess the impact of the ECB's unconventional monetary policy (UMP) on the wealth distribution of households in ten euro area countries. For this purpose, we estimate the effects of an ECB balance sheet expansion on financial asset and housing prices by means of vector autoregressions. We then use the estimates to carry out micro simulations based on data from the Household Finance and Consumption Survey (HFCS). We find that the overall effect of UMP on the net wealth distribution of households differs depending on which wealth inequality indicators we use. There is an inequality-increasing effect for the majority of the countries under review when we use wealth inequality indicators that are sensitive to changes at the tails of the wealth distribution. The effect is more equalizing when we base our assessment on the Gini coefficient. It is also important to note that one-third of the households in our sample does not hold financial or housing wealth and is thus not directly affected by UMP measures via the asset price channel.
Series: Department of Economics Working Paper Series
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Larose, Hailey Lee Ann. "Exploring the genetic basis of germination specificity in the parasitic plants Orobanche cernua and O. cumana." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/94423.

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Seeds of the root parasitic plants of the genus Orobanche germinate specifically in response to host-derived germination signals, which enables parasites to detect and attack preferred hosts. The best characterized class of germination stimulants is the strigolactones (SLs), although some species respond to non-SL compounds, such as dehydrocostus lactone (DCL). Recent work indicates that SLs are perceived by members of the KARRIKIN-INSENSITIVE2 (KAI2) gene family, and suggests that within parasitic Orobanchaceae the KAI2 genes have undergone duplication and specialization. The "diverged" clade of these genes, termed KAI2d, has been shown to bind SL germination stimulants in model system assays, but the precise role for KAI2d in regulating germination specificity in a parasitic plant has not been demonstrated. To address this issue, we used genetic and genomic approaches involving two closely related species, Orobanche cernua and O. cumana, which differ primarily in host range and stimulant preference. Orobanche cernua parasitizes tomato (and other Solanaceous crops) and responds to orobanchol, the major SL from tomato roots, whereas O. cumana specifically parasitizes sunflower and responds to DCL. Crosses between O. cernua and O. cumana produced hybrid populations that segregate for stimulant specificity, creating a tractable genetic system. Orobanche cernua contains four KAI2d genes (numbered OrceKAI2d1-4), while O. cumana contains six genes (OrcuKAI2d1-6). The DNA from 94 F2 hybrids was genotyped to identify the KAI2d gene composition and these were correlated with germination phenotype. The pattern of segregation indicated that the KAI2d genes are linked, but pointed to OrceKAI2d2 as a likely orobanchol receptor. Response to DCL was associated with inheritance of all O. cumana KAI2d genes together. Each KAI2d gene was expressed in the Arabidopsis thaliana kai2 mutant background and tested for ability to recover the mutant phenotype when exposed to SLs (including orobanchol, 5-deoxystrigol and GR24) or DCL. One O. cernua gene, OrceKAI2d2, responded to all SLs, but not DCL in this system. No DCL-specific KAI2 genes were identified. In summary, we have identified the likely SL receptor in O. cernua, and show evidence that the DCL receptor is either not a KAI2d protein, or uses KAI2d in combination with other signaling pathway components.
Ph. D.
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Auger, Isabelle. "Isolement et caracterisation de ligands specifiques de la troisieme region hypervariable de hla-drb1#*0401 (hla-dr4 dw4). Implications pour l'association polyarthrite rhumatoide et hla-dr4." Aix-Marseille 2, 1997. http://www.theses.fr/1997AIX22032.

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La sequence qkraa de la troisieme region hypervariable de hla-drb1#*0401 porte la susceptibilite a developper une polyarthrite rhumatoide. Le role de la sequence qkraa n'est pas encore connu. Il implique sans doute une interaction avec un ou plusieurs ligands. Nous avons recherche si la sequence qkraa de la troisieme region hypervariable de hla-drb1#*0401 interagit avec des proteines susceptibles de jouer un role dans la polyarthrite rhumatoide. Nous avons montre que : 1- le peptide de troisieme region hypervariable de hla-drb1#*0401 contenant qkraa fixe specifiquement la proteine de choc thermique bacterienne, dnak. Le motif qkraa suffit a fixer dnak. 2- le motif qkraa est implique dans l'interaction de dnak avec la proteine de choc thermique, dnaj, qui porte aussi la sequence qkraa. 3- dans les lignees lymphoblastoides humaines, hla-drb1#*0401 interagit specifiquement avec la proteine de choc thermique constitutive hsp73. Hsp73 transporte directement hla-drb1#*0401 du reticulum endoplasmique vers les lysosomes.
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Sugamori, Kim S. "The dopamine D1C receptor, expansion and origin of the dopamine D1 receptor family." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0001/NQ41320.pdf.

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Sculfort, Sabrina. "D10 -d10 interactions in heterometallic molecular clusters." Strasbourg, 2009. http://www.theses.fr/2009STRA6226.

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La réactivité du métallate [MoCp(CO)3]− vis à vis de complexe de cuivre(I), d’argent(I) et d’or(I) a conduit à une série de complexes hétérométalliques anioniques de formule [M{MoCp(CO)3}2]−(M = Cu(I), Ag(I), et Au(I)). Ces complexes ont été caractérisés par diffraction des rayons X et utilisés comme précurseurs de clusters mixtes à coeurs métalliques hexa- ou octanucléaire pseudo-plans. Ces clusters oligomériques {M[m]}n (M = Cu, n = 3; M = Ag, Au, n = 4) possèdent le même métalloligand pontant [m] = CpMo(CO)3 et ont pu être synthétisés et caractérisés. Le coeur métallique du cluster [Cu3{MoCp(CO)3}3] forme un triangle de fréquence 2 (ν2), constitué d’un triangle de cuivre ponté sur chacune de ses arêtes par un molybdène. Les clusters en “étoile” [Ag4{MoCp(CO)3}4] et [Au4{MoCp(CO)3}4] sont des carrés de fréquence 2 (ν2) formés d’un coeur métallique carré d’argent et d’or, respectivement, dont les arêtes sont pontées par un molybdène. Pour chacun de ces clusters, des distances courtes entre les ions d10 ont été mises en évidence, confirmant de réelles interactions entre ces centres métalliques. Des calculs théoriques ont été entrepris en collaboration pour comprendre ces interactions et leurs géométries. A partir des complexes « linéaires » [M{MoCp(CO)3}2]−, nous avons pu démontrer qu’une interconversion entre les chaînes {M[m]}n et les clusters {M[m]}n était possible dans le cas où M = Cu ou Ag et que la positon de l’équilibre dépendait seulement de la stoechiométrie des réactifs. De nouveaux complexes mixtes [CuAg3{MoCp(CO)3}4], [CuAu3{MoCp(CO)3}4] ont été obtenus et caractérisés par diffraction des rayons X ainsi qu’un complexe inattendu [(Na•DME)[Cu2{MoCp(CO)3}3]]2
Anionic, metal−metal bonded heterotrinuclear chain complexes of the type [M{MoCp(CO)3}2]− with M = Cu(I), Ag(I), and Au(I) have been prepared by reaction between a d10 metal precursor complex and the carbonylmetalate [MoCp(CO)3]−. These complexes have been structurally characterized by X-ray diffraction and used as precursors to neutral 2-D hexa- or octanuclear mixed-metal clusters of the general formula [MMoCp(CO)3]n (M = Cu, n = 3; M = Ag or Au, n 4). The ν2-triangular (M = Cu) or ν2-square (M = Ag, Au) structures of their metal-metal-bonded cores allow comparative evaluation of the d10-d10 interactions and theoretical calculations point to a favourable contribution of diagonal Au—Au or Ag—Ag interactions in the square structures. It is shown in the case of M = Cu and Ag that interconversion between the metal chain complexes of stoichiometry M[m]2 and the clusters {M[m]}n is possible, and the position of the equilibrium depends solely on the respective stoichiometry of the reagents. New ν2-square, octanuclear, trimetallic complexes [CuAg3{MoCp(CO)3}4] and [CuAu3{MoCp(CO)3}4] have also been obtained and characterized in the solid-state by X-ray diffraction, as well as the unexpected double pentanuclear complex [{Na(dme)}{Cu2[MoCp(CO)3]3}]2
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Fellner, Wolfgang, and Roman Seidl. "Satiated consumers: allocation of consumption time in an affluent society." Wiley, 2015. http://dx.doi.org/10.1111/meca.12080.

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Based on Ian Steedman's seminal contribution "Consumption Takes Time", we propose a formal activity-based model for consumer behaviour. The model simultaneously incorporates choices over consumption time, as well as quantities and qualities of products consumed. We identify and examine preconditions for satiation with products and draw implications for economic policy. Satiation with products explains the limited effects of price or income changes on demand and questions the pertinence of economic growth for development. It further highlights the relevance of working time reductions for well-being. (authors' abstract)
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Olshavsky, Nicholas. "Disruption of D-cyclin transcriptional regulation of the Androgen Receptor: Mechanism and Consequence." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1273168605.

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Larocque, Gabrielle. "Cell biology of tumor protein D54 (TPD54)." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/107000/.

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The expression of Tumor protein D52 (TPD52) family members is deregulated in many types of cancer. When overexpressed, it is suggested that they increase cell proliferation and migration/invasion as well as avoid apoptosis. Deregulation in the expression of the TPDs is therefore linked to poor prognosis. Little characterisation has been carried out to date, but it is known that the TPDs are found in association with components of the membrane trafficking pathway. The aim of this work is to uncover how the least studied member of the family, TPD54, affects cellular processes involved in carcinogenesis, such as cell migration and invasion. By using the knocksideways method, we have been able to map the cellular localisation of TPD54 and have identified association partners. These associations have been confirmed by immunoprecipitation and mass spectrometry analysis. Amongst these was the small GTPase Rab14. We have also found that TPD54 is involved in the trafficking of receptors containing a dileucine motif in their cytosolic tail, but not a tyrosine-based or NPXY motif. With the mapping of the localisation of TPD54, we hypothesise that TPD54 is on the recycling route following the Golgi apparatus, and in association with Rab14, regulates the trafficking of receptors containing a dileucine motif. Integrins are receptors controlling cell migration. They can be trafficked through the Golgi apparatus before being recycled back to the plasma membrane. This recycling route is not well characterised. We therefore hypothesise that TPD54 regulates this route with Rab14, and that this is the reason why TPD54 is important for cell migration, and that a defect in its function can cause cancer.
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Sougey, Everton Botelho. "Sistema LICET-D10 : multidiagnostico computadorizado das depressões." [s.n.], 1992. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308852.

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Orientador : Dorgival Caetano
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-07-16T00:39:35Z (GMT). No. of bitstreams: 1 Sougey_EvertonBotelho_D.pdf: 4844925 bytes, checksum: 291f969e456d1626dfc47f2898ce0653 (MD5) Previous issue date: 1992
Resumo: O desenvolvimento histórico da nosologia dos estados depressivos e as tentativas contemporâneas de reclassificação ilustram a origem de algumas dificuldades atuais e também sugerem novas perspectivas de investigação. A abordagem multidiagnóstica da nosologia foi o modelo em que o autor se baseou com o objetivo de desenvolver o SISTEMA UCET-D10, um instrumental de pesquisa sobre classificação das depressões. Este Sistema é composto pela Lista Integrada de Critérios de Avaliação Taxionômioa das Depressões - a LICET-D10; um Glossário de Definições de Sintomas e por um Programa Computadorizado de multidiagnóstico das depressões. O Sistema LICET-D10 foi testado numa amostra de 28 pacientes deprimidos e demonstrou sua funcionalidade. Este instrumental pode ser utilizado em pesquisa ou em clinica; favorece o treinamento em semiologia e nosologia das depressões; permite a obtenção de dez diagnósticos operacionais de depressão para cada paciente examinado; fornece amostras homogêneas de pacientes. permitindo facilmente executar a posteriori, reclassificações em subgrupos; possibilita comparações intersistemas entre as diversas categorias e subcategorias de estados depressivos. contribuindo para a investigação sobre confiabilidade e validade do diagnóstico psiquiátrico
Abstract: The historical developments of the nosology of depressive states and contemporary attempts at reclassification not only ilustrate the origin of some of the present difticulties but mo suggest new perspeetives of investigation. The multidiagnostie approaeh to nosology provides the model upon which the author based himsett with the objective of developing the LICET-D10 System, a research tool for the classification of depression. This System comprises the Integrated List of Taxionomie Eval.uation Criteria for Depression (LICET D10); a glossary of definitions of symptoms and a computerized program of multidiagnosis of depression. The LICET-D10 System was tested on a sample of 28 depressed patients and proved its operational effectiveness. This tool ean be used in research or clinical. practice; it furthers training in the semiology and nosology of depressions; provides ten operational. diagnoses for each patient examined; supplies homogeneous samples of patients, permitting a posterior and easy reclassifieation in subgroups; makes possible inter systemic comparisons between the difterent categories and subcategories of depressive states, thus contributing to the investigation into the reHabiHty and val.idity of psychiatric diagnosis
Doutorado
Saude Mental
Doutor em Medicina
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Books on the topic "D14"

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Hamadanizadeh, Soheila A. Pharmacological and functional differentiation of dopamine D1c and D1d receptor subtypes: Two novel members of the D1-like receptor family. Ottawa: National Library of Canada, 1996.

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Sakaev, Kostantin. The Queen's gambit accepted: 1.d4 d5 2.c4 dc4. 2nd ed. Sofia: Chess Stars, 2005.

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Hegemonie im Kunstfeld: Die documenta-Ausstellungen dX, D11, d12 und die Politik der Biennalisierung. Köln: König, 2008.

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Avrukh, Boris. 1. d4. Glasgow: Quality Press, 2008.

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Jefferson, Brian. Decision: D1. Oxford: Oxford University Press, 2008.

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Pamphilon, Steve. NVQ assessor D34 internal verifier award explained. Orpington: Harcro, 1998.

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Cowdogs & Crimefighters: Grades 4-8 (Accelerated Reader Book Set D14). Renaissance Learning Inc, 2000.

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BioSources Laboratory Program (Includes Labs D1-D12). Holt, 2002.

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Biotechnology: Includes Labs D1-D12 (Biosources Lab Program). Holt Rinehart & Winston, 1998.

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LCCI D34 Customised: LCCI D34 Customised. Financial Times Prentice Hall (a Pearson Education company), 1995.

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Book chapters on the topic "D14"

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Gready, Paul. "The Public Life of Narratives: Ethics, Politics, Methods." In Doing Narrative Research, 138–50. 1 Oliver's Yard, 55 City Road, London EC1Y 1SP: SAGE Publications, Ltd., 2008. http://dx.doi.org/10.4135/9780857024992.d10.

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Kohler Riessman, Catherine. "Concluding Comments." In Doing Narrative Research, 152–55. 1 Oliver's Yard, 55 City Road, London EC1Y 1SP: SAGE Publications, Ltd., 2008. http://dx.doi.org/10.4135/9780857024992.d11.

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Krainer, Michael, and Ahmed El-Gazzar. "DR4 and DR5." In Cancer Therapeutic Targets, 871–80. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4419-0717-2_9.

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Krainer, Michael, and Ahmed El-Gazzar. "DR4 and DR5." In Cancer Therapeutic Targets, 1–10. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-6613-0_9-2.

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Mihalyi, B., B. Siegele, Mahshid Sotoudeh, and R. Stifter. "Bewertung des Durchsetzungspotentials und der Wirtschaftlichkeit vorsorgender Umwelttechnologien, zwei Fallbeispiele; Endbericht, im Auftrag von: BMLFUW." In ITA - Elektronische Publikationen, ITA—pb—d17. Wien: Verlag der Österreichischen Akademie der Wissenschaften, 2000. http://dx.doi.org/10.1553/ita-pb-d17.

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Sotoudeh, Mahshid, and Susanne Schidler. "Anforderungen an Methoden zur Bewertung innovativer Technologien am Beispiel biologisch abbaubarer Polymere - Schwerpunkt komplexe Vernetzungen und gesellschaftliche Ambivalenz." In ITA - Elektronische Publikationen, ITA—pb—d18. Wien: Verlag der Österreichischen Akademie der Wissenschaften, 2000. http://dx.doi.org/10.1553/ita-pb-d18.

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Whitfield, Daniel, Sergey Akhmetov, Maryam Mohammad Al-Jallaf, Jose Blasques, Kamel Al-Aswad, and Ibrahim Baggash. "From D18 to D18+: Progression of Dubal's Original Potlines." In Light Metals 2015, 499–504. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781119093435.ch83.

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Whitfield, Daniel, Sergey Akhmetov, Maryam Mohammad Al-Jallaf, Jose Blasques, Kamel Al-Aswad, and Ibrahim Baggash. "From D18 to D18+: Progression of Dubal’s Original Potlines." In Light Metals 2015, 499–504. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-48248-4_83.

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He, Bin, and Kyoji Sassa. "Introduction: Session D1-D4—Side Events of World Landslide Forum." In Landslide Science for a Safer Geoenvironment, 431–34. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-04999-1_60.

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Winkelmann, Jochen. "Diffusion coefficient of ethanol-d1 into dideuterium oxide and urea-d4." In Diffusion in Gases, Liquids and Electrolytes, 3234–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-54089-3_2614.

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Conference papers on the topic "D14"

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Prasad, Manoj, Paul Taele, Ayobami Olubeko, and Tracy Anne Hammond. "[D14] HaptiGo: A navigational ‘tap on the shoulder’." In 2014 IEEE Haptics Symposium (HAPTICS). IEEE, 2014. http://dx.doi.org/10.1109/haptics.2014.6775543.

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Badami, Vivek G., Susan S. Hefner, and Stuart T. Smith. "Wavelet Analysis for Assessment of Localized Spectral Variations in Surface Topographic Data." In ASME 1995 Design Engineering Technical Conferences collocated with the ASME 1995 15th International Computers in Engineering Conference and the ASME 1995 9th Annual Engineering Database Symposium. American Society of Mechanical Engineers, 1995. http://dx.doi.org/10.1115/detc1995-0385.

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Abstract In this paper, a two dimensional wavelet analysis using Daubechies D14 wavelets has been used to decompose an Atomic Force Microscope image of the surface of a two dimensional calibration grid. Operating the microscope in open loop mode results in image distortions due to nonlinearities of the scanning mechanism which are subsequently reduced under closed loop control. Such distortions in the image are not readily apparent even using Fourier transform techniques and may be overlooked in a routine calibration. Through an appropriate choice of sample length so that the periodicity of the grid is coincident with the bandpass cut-off of the wavelet transform, it is shown in this paper that distortions can be clearly identified in individual levels of the wavelet reconstruction.
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Roukos, Salim. "Invited Talk: IBM Cognitive Computing - An NLP Renaissance!" In Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP). Stroudsburg, PA, USA: Association for Computational Linguistics, 2014. http://dx.doi.org/10.3115/v1/d14-1001.

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Gao, Jianfeng, Patrick Pantel, Michael Gamon, Xiaodong He, and Li Deng. "Modeling Interestingness with Deep Neural Networks." In Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP). Stroudsburg, PA, USA: Association for Computational Linguistics, 2014. http://dx.doi.org/10.3115/v1/d14-1002.

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Sundermeyer, Martin, Tamer Alkhouli, Joern Wuebker, and Hermann Ney. "Translation Modeling with Bidirectional Recurrent Neural Networks." In Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP). Stroudsburg, PA, USA: Association for Computational Linguistics, 2014. http://dx.doi.org/10.3115/v1/d14-1003.

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Van de Cruys, Tim. "A Neural Network Approach to Selectional Preference Acquisition." In Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP). Stroudsburg, PA, USA: Association for Computational Linguistics, 2014. http://dx.doi.org/10.3115/v1/d14-1004.

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Kiela, Douwe, and Léon Bottou. "Learning Image Embeddings using Convolutional Neural Networks for Improved Multi-Modal Semantics." In Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP). Stroudsburg, PA, USA: Association for Computational Linguistics, 2014. http://dx.doi.org/10.3115/v1/d14-1005.

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Stab, Christian, and Iryna Gurevych. "Identifying Argumentative Discourse Structures in Persuasive Essays." In Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP). Stroudsburg, PA, USA: Association for Computational Linguistics, 2014. http://dx.doi.org/10.3115/v1/d14-1006.

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Wang, Zhuoran, Hongliang Chen, Guanchun Wang, Hao Tian, Hua Wu, and Haifeng Wang. "Policy Learning for Domain Selection in an Extensible Multi-domain Spoken Dialogue System." In Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP). Stroudsburg, PA, USA: Association for Computational Linguistics, 2014. http://dx.doi.org/10.3115/v1/d14-1007.

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Kong, Fang, Hwee Tou Ng, and Guodong Zhou. "A Constituent-Based Approach to Argument Labeling with Joint Inference in Discourse Parsing." In Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP). Stroudsburg, PA, USA: Association for Computational Linguistics, 2014. http://dx.doi.org/10.3115/v1/d14-1008.

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Reports on the topic "D14"

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Peretich, Michael, Geoffrey eldridge, John Krizovensky, and Douglas Mearns. Joint Oil Analysis Program Spectrometer Standards VHG Labs Inc. Qualification Report for D19-0, D3-100 and D12-XXX Series Standards. Fort Belvoir, VA: Defense Technical Information Center, September 2013. http://dx.doi.org/10.21236/ada618976.

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Peretich, Michael, Pedro Farias, and Douglas Mearns. Joint Oil Analysis Program Spectrometer Standards SCP Science (Conostan) Qualification Report for D19-0, D3-100, and D12-XXX Series Standards. Fort Belvoir, VA: Defense Technical Information Center, May 2015. http://dx.doi.org/10.21236/ada618977.

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Ayoul-Guilmard, Q., S. Ganesh, F. Nobile, R. Badia, J. Ejarque, L. Cirrottola, A. Froehly, et al. D1.4 Final public Release of the solver. Scipedia, 2021. http://dx.doi.org/10.23967/exaqute.2021.2.009.

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This deliverable presents the final software release of Kratos Multiphysics, together with the XMC library, Hyperloom and PyCOMPSs API definitions [13]. This release also contains the latest developements on MPI parallel remeshing in ParMmg. This report is meant to serve as a supplement to the public release of the software. Kratos is “a framework for building parallel, multi-disciplinary simulation software, aiming at modularity, extensibility, and high performance. Kratos is written in C++, and counts with an extensive Python interface”. XMC is “a Python library for parallel, adaptive, hierarchical Monte Carlo algorithms, aiming at reliability, modularity, extensibility and high performance“. Hyperloom and PyCOMPSs are environments for enabling parallel and distributed computation. ParMmg is an open source software which offers the parallel mesh adaptation of three dimensional volume meshes.
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4

Author, Not Given. Resource Conservation and Recovery Act, Part B Permit Application [for the Waste Isolation Pilot Plant (WIPP)]. Volume 6, Chapter D, Appendices D4--D13: Revision 1.0. Office of Scientific and Technical Information (OSTI), December 1991. http://dx.doi.org/10.2172/10151271.

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Author, Not Given. Resource Conservation and Recovery Act, Part B permit application [of the Waste Isolation Pilot Plant (WIPP)]. Volume 11, Chapter D, Appendix D4--Chapter D, Appendix D17: Revision 3. Office of Scientific and Technical Information (OSTI), March 1993. http://dx.doi.org/10.2172/10132915.

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Sampson P. and S. Y. Zhang. Beam Loss Pattern at DH4 in the BTA Line. Office of Scientific and Technical Information (OSTI), June 1996. http://dx.doi.org/10.2172/1132429.

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Mensink, Manon, Eric Boer, and Esther Hogeveen. Monitoring en voorspelling van kwaliteit van verse champignons : GreenCHAINge DP4 Champignons. Wageningen: Wageningen Food & Biobased Research, 2019. http://dx.doi.org/10.18174/503213.

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Meesters, Koen. CAPCOM-NL. D1, Biomass sourcing. Wageningen: Wageningen Food & Biobased Research, 2021. http://dx.doi.org/10.18174/549834.

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Lambertucci, Stefano. INFO Sheet D04: End-Users Decision Making Factors for H&C Systems. IEA SHC Task 54, April 2018. http://dx.doi.org/10.18777/ieashc-task54-2018-0002.

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Marchand, Alan P., N. Satyanarayana, Jr McKenney, Struck Robert L., and Stephen R. Synthesis of 1,4-Butanediamine-1,1,4,4-d4, 1,4-Butanediamine-2,2,3,3-d4 and Their Respective BIS (Ammonium Nitrate) Salts. Fort Belvoir, VA: Defense Technical Information Center, December 1987. http://dx.doi.org/10.21236/ada194518.

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