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1
MacDonald, Craig. "A new approach for DAEs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0027/NQ49847.pdf.
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Jansen, Lennart. "A Dissection concept for DAEs." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2015. http://dx.doi.org/10.18452/17166.
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Diese Arbeit befasst sich mit Differential-algebraischen Gleichungen (DAEs). DAEs spielen eine wichtige Rolle in der Modellierung, der Simulation und der Optimierung von Netzwerken und gekoppelten Problemen in vielen Anwendungsgebieten. Es werden in Bezug auf die Modellierung und die numerische Simulation von DAEs bereits bestehende Ergebnisse diskutiert und erweitert. Des Weiteren wird die globale eindeutige Lösbarkeit und die Sensitivität der Lösungen mit Hinsicht auf Störungen der DAEs untersucht. Häufig wird die Modellierung von multiphysikalischen Anwendungen durch die Kopplung mehrerer einzelner DAE Systeme realisiert. Diese Herangehensweise kann hochdimensionale DAEs erzeugen, welche aufgrund von Instabilitäten nicht von klassischen numerischen Methoden, simuliert werden können. Angesichts dieser Herausforderungen werden drei Ziele formuliert: Erstens wird ein globales Lösungstheorem formuliert und bewiesen, welches auf gekoppelte Systeme angewandt werden kann, um deren Kopplungsansatz mathematisch zu rechtfertigen. Zweitens werden numerische Methoden vorgestellt, welche unter wesentlich schwächeren Strukturannahmen stabil sind und sich daher für die Simulation von gekoppelten Systemen eignen. Drittens wird eine Strategie präsentiert, die es ermöglicht, explizite Methoden auf gekoppelte Systeme anzuwenden. Um diese Ziele zu erreichen, braucht man ein Entkopplungsverfahren für DAEs, welches die folgenden drei Eigenschaften erfüllt: Die Komplexität des Entkopplungsverfahrens sollte nicht die Komplexität der DAE überschreiten. Das Entkopplungsverfahren sollte Eigenschaften wie Symmetrie, Monotonie und positive Definitheit erhalten. Das Entkopplungsverfahren sollte durch einen Schritt-für-Schritt Ansatz mit unabhängigen Schritten realisiert werden. Sowohl das Konzept des Tractability Index als auch das des Strangeness Index liefert kein solches Entkopplungsverfahren. Daher wird hier ein neues Index Konzept eingeführt, das diesen Anforderungen entspricht.This thesis addresses differential-algebraic equations (DAEs). They play an important role in the modeling, simulation and optimization of networks and coupled problems in various applications. The main application in this thesis are coupled problems in electric circuit simulation. We discuss and extend existing results regarding the modeling and numerical simulation of DAEs. Furthermore, we investigate the global unique solvability and the sensitivity of solutions with respect to perturbations of DAEs. Nowadays the modeling of multi-physical applications is often realized by coupling systems of DAEs together with the help of additional coupling terms. This approach may yield high dimensional DAEs which cannot be simulated, due to instabilities, by standard numerical methods. Regarding these challenges we formulate three objectives: First we provide a global solvability theorem which can be applied to coupled systems to mathematically justify their coupling approach. Second we introduce numerical methods which are stable without needing any structural assumptions. Third we provide a way to apply explicit methods to coupled systems to be able to handle the size of the coupled systems by parallelizing the algorithms. To achieve these objectives, we need a decoupling procedure which fulfills the following three properties: The complexity of the decoupling procedure has to reflect the complexity of the DAE, i.e. the decoupling procedure should be state-independent if possible. The decoupling procedure should preserve properties like symmetry, monotonicity and positive definiteness. The decoupling procedure should be realized by a step-by-step approach with independent stages. Both the Tractability Index concept and the Strangeness Index concept do not provide such a decoupling procedure. For this reason we introduce a new index concept which provides such a decoupling procedure.
3
Ascher, Uri M., Hongsheng Chin, and Sebastian Reich. "Stabilization of DAEs and invariant manifolds." Universität Potsdam, 1994. http://opus.kobv.de/ubp/volltexte/2007/1562/.
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Many methods have been proposed for the stabilization of higher index differential-algebraic equations (DAEs). Such methods often involve constraint differentiation and problem stabilization, thus obtaining a stabilized index reduction. A popular method is Baumgarte stabilization, but the choice of parameters to make it robust is unclear in practice. Here we explain why the Baumgarte method may run into trouble. We then show how to improve it. We further develop a unifying theory for stabilization methods which includes many of the various techniques proposed in the literature. Our approach is to (i) consider stabilization of ODEs with invariants, (ii) discretize the stabilizing term in a simple way, generally different from the ODE discretization, and (iii) use orthogonal projections whenever possible. The best methods thus obtained are related to methods of coordinate projection. We discuss them and make concrete algorithmic suggestions.
4
Hoffmann, Rico. "Selbstadjungierte lineare DAEs und ihre Numerik." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-160874.
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Schröter, Julian [Verfasser]. "Zusammenhang von Twitter-Stimmung und DAX : DAX-Vorhersage mit Twitter? / Julian Schröter." Siegen : Universitätsbibliothek der Universität Siegen, 2019. http://d-nb.info/1189421941/34.
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Kwan, Pak-shing, and 關百誠. "Roles of Daxx in mitosis and prostate carcinogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085337.
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Kwan, Pak-shing. "Roles of Daxx in mitosis and prostate carcinogenesis." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085337.
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Mann, Joe͏̈lle. "Marc Dax, médecin de Sommières." Montpellier 1, 1992. http://www.theses.fr/1992MON11106.
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Almeida, Vera Luci de. "DAES - modelo para diagnóstico ambiental em estabelecimentos de saúde." Florianópolis, SC, 2003. http://repositorio.ufsc.br/xmlui/handle/123456789/84753.
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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de ProduçãoMade available in DSpace on 2012-10-20T12:12:21Z (GMT). No. of bitstreams: 1 205600.pdf: 906792 bytes, checksum: 91f08ab3a5233bf2abab76e12625ef90 (MD5)
Este trabalho apresenta uma proposta metodológica para um diagnóstico ambiental em estabelecimentos de saúde, visando, com ênfase nos critérios de gerenciamento ambiental, identificar os pontos positivos e negativos do manejo de resíduos de serviços de saúde dos estabelecimentos, a fim de poder propor ações de melhorias no desempenho ambiental dos mesmos. O modelo Diagnóstico Ambiental em Estabelecimentos de Saúde # DAES, proposto, tem como fundamentação teórica, para a elaboração de seus critérios, a legislação vigente sobre o manejo e disposição final de resíduos de serviços de saúde (RSS), constantes nas Resoluções da Agência de Vigilância Sanitária e Conselho Nacional de Meio Ambiente (RDC 33/03 e, 5/93 e 283/01, respectivamente), contando ainda, com as disposições das Normas da Associação Brasileira de Normas Técnicas (ABNT) sobre o assunto. O gerenciamento das rotinas e procedimentos dos estabelecimentos, com base nestas legislações, permite administrar as relações entre as atividades do estabelecimento e o meio ambiente. Assim, buscando validar o modelo proposto, aplicou-se, o mesmo, em 26 estabelecimentos de saúde de Santa Catarina, o que produziu um diagnóstico ambiental do setor. Com base no modelo aplicado foi possível constatar que a ferramenta é de fácil aplicação e análise, além de poder ser considerada uma ferramenta de sensibilização para a administração, quanto a necessidade de melhoras no gerenciamento ambiental do estabelecimento, mostrando-se adequada para uma avaliação inicial do desempenho ambiental do mesmo.
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Partika, Marek. "Publikace dat ze sítě meteostanic ve formátu DATEX II." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2016. http://www.nusl.cz/ntk/nusl-240798.
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Master’s thesis deals with implementation of a European standard DATEX II. This standard specifies the data format for information transmission in road transport. The road traffic is flowing streams of current information. For the work was selected network of meteorological stations, which will publish the measured data, ie weather conditions of road transport. Measured data will be available to consumers in the format DATEX II. Implementation will be operational in its entirety meteorological station from design to the actual web service that will produce data information for consumers.
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Ascher, Uri M., Hongsheng Chin, Linda R. Petzold, and Sebastian Reich. "Stabilization of constrained mechanical systems with DAEs and invariant manifolds." Universität Potsdam, 1994. http://opus.kobv.de/ubp/volltexte/2007/1569/.
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Many methods have been proposed for the simulation of constrained mechanical systems. The most obvious of these have mild instabilities and drift problems. Consequently, stabilization techniques have been proposed A popular stabilization method is Baumgarte's technique, but the choice of parameters to make it robust has been unclear in practice.
Some of the simulation methods that have been proposed and used in computations are reviewed here, from a stability point of view. This involves concepts of differential-algebraic equation (DAE) and ordinary differential equation (ODE) invariants. An explanation of the difficulties that may be encountered using Baumgarte's method is given, and a discussion of why a further quest for better parameter values for this method will always remain frustrating is presented. It is then shown how Baumgarte's method can be improved.
An efficient stabilization technique is proposed, which may employ explicit ODE solvers in case of nonstiff or highly oscillatory problems and which relates to coordinate projection methods. Examples of a two-link planar robotic arm and a squeezing mechanism illustrate the effectiveness of this new stabilization method.
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Singer, Oleg. "Aufsichtsräte der DAX-Unternehmen Qualifikation und Vergütung." Hamburg Diplomica-Verl, 2009. http://d-nb.info/999571362/04.
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Němeček, Jiří. "Analýza akciových titulů z burzovního indexu DAX." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-1625.
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Diplomová práce se zabývá analýzou akciových titulů z německého burzovního indexu DAX. Úvodní kapitola diplomové práce obsahuje korelační analýzu indexu DAX s dalšími akciovými indexy. Hlavní kapitola je zaměřena na využití fundamentální analýzy při ohodnocování akciových titulů z dotyčného burzovního indexu DAX. Ohodnocování akciových titulů je prováděno pomocí dividendového diskontního modelu a modelů ziskových. Závěr tvoří zkoumání úspěšnosti investičních strategií založených na fundamentálních akciových ukazatelích.
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Le, Fanic Ronan. "Hydrogéologie d'un système thermal et modélisation couplée hydrodynamique, thermique en vue de la gestion de la ressource : application au système de Dax - Saint-Paul-Lès-Dax." Bordeaux 3, 2005. http://www.theses.fr/2005BOR30051.
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La valorisation de l'eau thermale et le développement du thermalisme, tant médical que ludique, nécessitent aujourd'hui une connaissance approfondie de l'origine des eaux, en particulier du Bas-Adour, ainsi que la connaissance réelle des quantités disponibles sans risque de perturber la qualité de cette ressource. Malgré la complexité naturelle des sites d'émergences, il est aujourd'hui possible, en particulier sur le site de Dax – Saint-Paul-Lès-Dax, de réaliser un modèle hydrogéologique prédictif grâce à de nouveaux logiciels de simulation particulièrement performants. L'ensemble des données disponibles ont été rassemblées et mises en cohérence afin de revisiter le contexte géologique et hydrogéologique du système hydrothermal dacquois. Les chroniques de températures et de hauteurs piézométriques ont été analysées par des méthodes modernes afin d'en tirer des renseignements sur les perturbations engendrées par l'exploitation thermale et permettre la caractérisation du comportement hydrodynamique de l'aquifère thermal. Toutes ces informations ont ensuite servi à l'élaboration de différents modèles hydrogéologiques et thermiques. Tout d'abord, un modèle 2D vertical à caractère explicatif des phénomènes a été construit afin de comprendre le mode de fonctionnement du système. Ensuite notre approche nous a conduit à réaliser un modèle 3D couplé hydrodynamique et thermique de l'ensemble de la structure hydrothermale dacquoise. Puis, un modèle 3D local a permis de simuler l'impact des prélèvements, ainsi que l'influence des différentes activités envisagées en d'autres secteurs de l'aquifère. Il pourra, à l'avenir, servir d'outil pour une gestion optimisée de la ressource thermale.
15
Stankov, Dimitre [Verfasser]. "Die Kapitalverflechtungen hinter dem DAX 30 / Dimitre Stankov." Berlin : Freie Universität Berlin, 2008. http://d-nb.info/102302294X/34.
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Oliva, Federico. "Modelling, stability, and control of DAE numerical integration." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20143/.
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This thesis deals with the integration of differential algebraic equations systems. Generally speaking the execution of numerical integration algorithms may introduce some errors, which could propagate ending up in a wrong description of system dynamics. This issue, named drifting, will be highlighted by dealing with a specific constrained mechanical system presenting. Such system consists of a looper, which is a mechanism used in the steel production to sense and control the tension acting on the material. The thesis unfolds as follows: a first section model the looper and inspects the main properties related to its joint space and singularities. A brief introduction to stability analysis on multidof systems is proposed. Then, the thesis proceeds analysing looper stability properties, eventually finding a globally asymptotic stable configuration. Lastly, the drifting is highlighted by numerical simulations. To solve this issue two control algorithms are proposed: the first is the Baumgarte algorithm and the second consists of a nonlinear stabilizer. A performance comparison of both algorithms is then presented at the end of the implementation description.
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Wichmann, Tim [Verfasser]. "Symbolische Reduktionsverfahren für nichtlineare DAE-Systeme / Tim Wichmann." Aachen : Shaker, 2004. http://d-nb.info/1172612706/34.
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Eisemann, Lars. "Die Bewertung von Strukturierten Produkten auf den DAX." St. Gallen, 2006. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/02606887001/$FILE/02606887001.pdf.
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Cadeau, Valérie. "Les eaux hyperthermales et le péloi͏̈de de Dax." Paris 5, 1993. http://www.theses.fr/1993PA05P120.
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Lartigolle, Jocelyne. "Le peloïde de Dax et ses indications thérapeutiques." Bordeaux 2, 1995. http://www.theses.fr/1995BOR2M099.
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Guchan, Philippe. "Thermalisme et pathologie veineuse à Dax : à propos d'une enquête prospective portant sur 71 cas." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M078.
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Papi, Cathia Marquet Pascal Triby Emmanuel. "Le dispositif vécu au coeur de la préparation du DAEU à distance." Strasbourg : Université Louis Pasteur, 2008. http://eprints-scd-ulp.u-strasbg.fr:8080/886/01/PAPI_Cathia_2007_v1.pdf.
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Bove, Marina Heckmann. "Caracterização de genes de virulência de Escherichia coli de adesão difusa (DAEC)." reponame:Repositório Institucional da UnB, 2010. http://repositorio.unb.br/handle/10482/7135.
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Dissertação (mestrado)-Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, 2010.Submitted by Shayane Marques Zica (marquacizh@uol.com.br) on 2011-03-16T19:35:34Z No. of bitstreams: 1 2010_MarinaHeckmannBove.pdf: 14274068 bytes, checksum: 39c7fd2195ca55b34fee3168e4913b60 (MD5)
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Embora as Escherichia coli de adesão difusa (DAEC) sejam classificadas como um dos seis grupos de E. coli diarreiogênicas, sua patogenicidade ainda é controversa. Diversas linhagens de bactérias intestinais, incluindo Escherichia coli, Yersinia enterocolitica, Shigella flexneri e Salmonella enterica, possuem em seu genoma uma ilha de patogenicidade (PAI) contendo genes que codificam um Sistema de Secreção do Tipo III (TTSS), responsável pela transferência de proteínas efetoras do citoplasma da bactéria diretamente para o citoplasma da célula hospedeira. A presença de genes TTSS é, portanto, um forte indicativo de virulência. Tendo em vista tais informações, este trabalho teve como objetivos a identificação e caracterização de potenciais genes TTSS de isolados de DAEC recuperados de crianças diarréicas. Experimentos de PCR utilizando iniciadores direcionados aos genes TTSS escD, espA, espD, espB e escF resultaram na detecção de sete prováveis genes em três isolados de DAEC. Dentre as sequências obtidas, detectou-se a presença dos genes espA, espB e escF completos em dois desses isolados de DAEC. Análises de identidade desses genes em relação aos homólogos de diversas linhagens de enteropatógenos sugerem que os isolados de DAEC são bastante heterogêneos. Além disso, as identidades dos genes TTSS de DAEC em relação aos homólogos de diferentes linhagens de E. coli enteropatogênicas e enterohemorrágicas são bastante elevadas, podendo atingir 100%. A construção de árvores filogenéticas empregando as sequências desses genes confirmou tais resultados e demonstrou que os isolados C39 e C74 são evolutivamente mais próximos entre si que em relação à DAEC C40, agrupada no mesmo clado da EPEC prototípica E2348/69. Ensaios de transcrição reversa utilizando RNA dos isolados C39 e C74 revelaram ainda que alguns dos possíveis genes consistem em genes de fato, uma vez que são transcritos sob indução. Com a finalidade de verificar a expressão dos genes TTSS de DAEC foram também realizados experimentos de microscopia eletrônica e de microscopia de força atômica, porém, as imagens obtidas por meio dessas técnicas foram inconclusivas. Conjuntamente, os resultados apresentados neste trabalho sugerem fortemente a presença de uma PAI contendo genes TTSS em DAEC, e constituem evidências a favor da patogenicidade desse grupo de E. coli. _________________________________________________________________________________ ABSTRACT
Although diffusely adhering Escherichia coli (DAEC) are classified as one of the six pathotypes of diarrheiogenic E. coli, their pathogenicity is still controversial. Several strains of bacteria, including Escherichia coli, Yersinia enterocolitica, Shigella flexneri and Salmonella enterica, possess a pathogenicity island (PAI), containing genes that code for a Type III Secretion System (TTSS), dedicated to inject effector proteins directly from the bacterial cytoplasm into the host cell cytoplasm. Therefore, the presence of TTSS genes is considered a strong evidence of virulence of a given microorganism. This work describes the identification and characterization of potential TTSS genes in DAEC isolates recovered from diarrheic children. PCR experiments using primers targeted to the TTSS genes escD, espA, espD, espB and escF resulted in the detection of seven putative genes in three isolates of DAEC. Among the sequences obtained, it was possible to detect the presence of the complete espA, espB and escF genes in two of the DAEC isolates. Identity analyses of these genes with different strains suggest that DAEC isolates are quite heterogeneous. Moreover, the identities of TTSS genes of DAEC compared to enteropathogenic and enterohaemorrhagic E. coli are very high, sometimes reaching 100%. The construction of phylogenetic trees using the sequences of these genes confirmed these findings and showed that the isolates C39 and C74 are evolutionarily closer to each other than to the C40 DAEC isolate, which was grouped in the same clade of the prototypical EPEC E2348/69. Tests using reverse transcription of RNA isolated from C39 and C74 also revealed that some of the putative genes consist of true genes, since they were transcribed under induction conditions. In order to analyze the expression of TTSS genes in DAEC, electron microscopy and atomic force microscopy experiments were also carried out, however, the images obtained by these techniques were inconclusive. Together, the results obtained in this work strongly suggest the presence of a PAI containing TTSS genes in DAEC, and constitute evidence for the pathogenicity of this group of E. coli.
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Papi, Cathia. "Le dispositif vécu au coeur de la préparation du DAEU à distance." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. https://publication-theses.unistra.fr/public/theses_doctorat/2007/PAPI_Cathia_2007.pdf.
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Enquêtant sur la préparation du diplôme d’accès aux études universitaires (DAEU) à distance, nous nous intéressons à l’activité et aux représentations des acteurs engagés, à différents niveaux, dans un campus numérique. Ce faisant, plutôt que concevoir le dispositif comme un simple environnement, nous l’appréhendons sous l’angle du vécu de ses acteurs. Envisageant le dispositif comme un entre-deux médiatif, ni extérieur, ni intérieur, ni simple moyen, ni immédiateté pour le sujet dont l’action, fonction des situations, fait évoluer le dispositif initialement conçu, notre thèse ne vise ainsi pas tant à démontrer un phénomène qu’à proposer une lecture d’un dispositif de FOAD en mettant en avant que, derrière un seul dispositif écrit existent plusieurs dispositifs vécus se manifestant par différentes zones de valeurs fonctionnelles partagées corrélées aux sens que revêtent, pour ses acteurs, les situations auxquelles ils participent aussi bien en amont qu’au cours de leur formationIn investigating the preparation of the diploma that has allowed access to distant university studies, we focus on the activity and representations of the participating actors-stakeholders, at different levels, in a digital campus. Rather than viewing the system as a simple environment, we will look at it from the angle of its actors’ actual experience. We view and interpret the system as a “media period in between”, neither exterior, nor interior, nor a simple means, nor immediacy for the subject whose actions, depending on the situations, makes the initial system evolve. Applicable to the “experience-based system”, our theoretical framework does not purport to prove a phenomenon as proposing an interpretation of a ODL system. Rather, this approach is based upon the premise that behind a single “written system” there are several “experience-based systems” that show different “zones of shared functional values” related to the situations the actors take part during their education
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Maillet, Sarah. "Inhibition de la transcription inverse du VIH-1 par la protéine Daxx." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT062.
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Daxx (Death domain-associated protein 6), est une protéine multifonctionnelle exprimée de façon ubiquitaire majoritairement dans le noyau des cellules, où il se trouve associé aux corps nucléaires formés par la protéine PML. En 2015, l’équipe a identifié Daxx comme un facteur de résistance à certains rétrovirus, dont le VIH-1. Daxx cible plus précisément la transcription inverse du VIH-1, une étape essentielle et spécifique du cycle de réplication des rétrovirus, au cours de laquelle le génome viral sous forme ARN est converti en un ADN double brin capable de s’intégrer au génome de l’hôte. Les travaux que nous avons entrepris avaient pour but d’élucider le mécanisme de restriction imposé par Daxx, notamment en identifiant les partenaires impliqués dans cette activité antivirale. Nous avons d’abord montré que la région SIM localisée en C-terminale de Daxx, un domaine qui lui permet d’interagir avec des protéines SUMOylées, était nécessaire à sa fonction inhibitrice. Après différentes mises au point, un crible protéomique complété d’expériences d’immunoprécipitation ont montré que Daxx s’associe aux particules virales entrantes par l’intermédiaire d’une interaction avec la cyclophiline A dépendante de la région SIM de Daxx. Cette interaction est à l’origine de la formation d’un complexe multiprotéique également constitué de TRIM5α, TRIM34 et TNPO3. Sachant que certains de ces facteurs influencent la stabilité de la capside d’une part, et que la transcription inverse est étroitement liée à l’étape de décapsidation, nous nous sommes interrogés sur l’implication de Daxx dans la stabilité des capsides. Nous avons ainsi montré que Daxx stabilise les capsides virales de manière SIM-dépendante. Nos résultats suggèrent que Daxx, en s’associant à la CypA liée aux capsides entrantes par l’intermédiaire de son motif SIM, recrute d’autres partenaires comme TRIM5α, TRIM34 ou TNPO3, ce qui provoque la stabilisation des capsides et empêche la décapsidation et la transcription inverseDaxx is a multifunctional ubiquitously expressed protein, mainly found in the nucleus, where it associates with nuclear structures called PML nuclear bodies. In a previous study, the team showed that antiviral effect of PML was not direct and identified Daxx as a novel restriction factor which interferes with an early step of HIV-1 and other retroviruses replication cycle. Daxx indeed targets the reverse transcription, an essential step responsible for the RNA viral genome conversion in a double stranded DNA that can integrate in the cellular host genome. In order to decipher the mechanism underlying Daxx-mediated inhibition of HIV-1 reverse transcription, we sought to identify Daxx’s partners involve in this antiviral activity. We first showed that the C-terminus domain of Daxx called SIM, for SUMO-interacting motif, was required for its antiviral activity. A proteomic screen combined with biochemical approaches showed that Daxx associates with incoming viral cores in a SIM-dependant interaction with cyclophilin A (CypA). Daxx is found in a multiprotein complex associated with incoming viral particles and containing TRIM5α, TRIM34 and TNPO3. Knowing that some of these factors influence HIV-1 core stability, we investigated the effect of Daxx on the fate of incoming viral particles, and showed that Daxx interferes HIV-1 uncoating in a SIM-dependant manner. Altogether, our findings suggest that Daxx interacts with CypA associated with viral capids to recruit a multiprotein complex containing TRIM5α, TRIM34 and TNPO3 in order to stabilize the viral cores thus preventing uncoating and reverse transcription
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Wyatt, Sarah Alice. "Issues in Interpolatory Model Reduction: Inexact Solves, Second-order Systems and DAEs." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/27668.
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Dynamical systems are mathematical models characterized by a set of differential or difference equations.
Model reduction aims to replace the original system with a reduced system of significantly smaller dimension that still describes the important dynamics of the large-scale
model. Interpolatory model reduction methods define a reduced model that interpolates the full model at selected interpolation points. The reduced model may be obtained through a Krylov reduction process or by using the Iterative Rational Krylov Algorithm (IRKA), which iterates this Krylov reduction process to obtain an optimal $\mathcal{H}_2$ reduced model.
This dissertation studies interpolatory model reduction for first-order descriptor systems, second-order systems, and DAEs. The main computational cost of interpolatory model reduction is the associated linear systems. Especially in the large-scale setting, inexact solves become desirable if not necessary. With the introduction of inexact solutions, however, exact interpolation no longer holds. While the effect of this loss of interpolation has previously been studied, we extend the discussion to the preconditioned case. Then we utilize IRKA's convergence behavior to develop preconditioner updates.
We also consider the interpolatory framework for DAEs and second-order systems. While interpolation results still hold, the singularity associated with the DAE often results in unbounded model reduction errors. Therefore, we present a theorem that guarantees interpolation and a bounded model reduction error. Since this theorem relies on expensive projectors, we demonstrate how interpolation can be achieved without explicitly computing the projectors for index-1 and Hessenberg index-2 DAEs. Finally, we study reduction techniques for second-order systems. Many of the existing methods for second-order systems rely on the model's associated first-order system, which results in computations of a $2n$ system. As a result, we present an IRKA framework for the reduction of second-order systems that does not involve the associated $2n$ system. The resulting algorithm is shown to be effective for several dynamical systems.Ph. D.
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Teitge, Jonas, and Andreas Nastansky. "Interdependenzen in den Renditen DAX-notierter Unternehmen nach Branchen." Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2011/5208/.
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Die Identifikation von Einflussfaktoren und deren Wirkungsrichtung auf die Kursentwicklung einer Aktie ist von großer Bedeutung für die Finanzmarktanalyse. Die wechselseitigen Zusammenhänge zwischen den Renditen spezifischer Aktien sind solche relevante Informationen. In diesem Beitrag werden die Interdependenzen von Aktienrenditen auf der Grundlage vektorautoregressiver (VAR)-Modelle für kleine, homogene Brachen- und Marktsegmente analysiert. Hierzu wurden die Renditen ausgewählter im Deutschen Aktienindex (DAX) notierter Unternehmen zu drei Branchensegmenten zusammengefasst. Darüber hinaus zeigt sich am Beispiel der Hoechst-Aktie, dass eine gemeinsame DAX-Notierung Einfluss auf das Beziehungsgeflecht der Renditen innerhalb eines Brachensegmentes nimmt.
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Sjöberg, Johan. "Optimal Control and Model Reduction of Nonlinear DAE Models." Doctoral thesis, Linköpings universitet, Reglerteknik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11345.
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In this thesis, different topics for models that consist of both differential and algebraic equations are studied. The interest in such models, denoted DAE models, have increased substantially during the last years. One of the major reasons is that several modern object-oriented modeling tools used to model large physical systems yield models in this form. The DAE models will, at least locally, be assumed to be described by a decoupled set of ordinary differential equations and purely algebraic equations. In theory, this assumption is not very restrictive because index reduction techniques can be used to rewrite rather general DAE models to satisfy this assumption. One of the topics considered in this thesis is optimal feedback control. For state-space models, it is well-known that the Hamilton-Jacobi-Bellman equation (HJB) can be used to calculate the optimal solution. For DAE models, a similar result exists where a Hamilton-Jacobi-Bellman-like equation is solved. This equation has an extra term in order to incorporate the algebraic equations, and it is investigated how the extra term must be chosen in order to obtain the same solution from the different equations. A problem when using the HJB to find the optimal feedback law is that it involves solving a nonlinear partial differential equation. Often, this equation cannot be solved explicitly. An easier problem is to compute a locally optimal feedback law. For analytic nonlinear time-invariant state-space models, this problem was solved in the 1960's, and in the 1970's the time-varying case was solved as well. In both cases, the optimal solution is described by convergent power series. In this thesis, both of these results are extended to analytic DAE models. Usually, the power series solution of the optimal feedback control problem consists of an infinite number of terms. In practice, an approximation with a finite number of terms is used. A problem is that for certain problems, the region in which the approximate solution is accurate may be small. Therefore, another parametrization of the optimal solution, namely rational functions, is studied. It is shown that for some problems, this parametrization gives a substantially better result than the power series approximation in terms of approximating the optimal cost over a larger region. A problem with the power series method is that the computational complexity grows rapidly both in the number of states and in the order of approximation. However, for DAE models where the underlying state-space model is control-affine, the computations can be simplified. Therefore, conditions under which this property holds are derived. Another major topic considered is how to include stochastic processes in nonlinear DAE models. Stochastic processes are used to model uncertainties and noise in physical processes, and are often an important part in for example state estimation. Therefore, conditions are presented under which noise can be introduced in a DAE model such that it becomes well-posed. For well-posed models, it is then discussed how particle filters can be implemented for estimating the time-varying variables in the model. The final topic in the thesis is model reduction of nonlinear DAE models. The objective with model reduction is to reduce the number of states, while not affecting the input-output behavior too much. Three different approaches are studied, namely balanced truncation, balanced truncation using minimization of the co-observability function and balanced residualization. To compute the reduced model for the different approaches, a method originally derived for nonlinear state-space models is extended to DAE models.
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Körkel, Stefan. "Numerische Methoden für optimale Versuchsplanungsprobleme bei nichtlinearen DAE-Modellen." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965532534.
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Sjöberg, Johan. "Optimal control and model reduction of nonlinear DAE models /." Linköping : Department of Electrical Engineering, Linköping University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11345.
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Nikoli, Ioanna, and Md Mosharof Hossain. "Relationship between currency carry trade and DAX & DJIA." Thesis, Umeå universitet, Företagsekonomi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-115204.
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Abstract: The last decade currency carry trade has gained a lot of popularity because of their apparent profitability. It is a strategy that has been developed to exploit violations of the Uncovered Interest Rate Parity. In particular, an investor must take a short position in a low-yielding currency to fund a long position in a high-yielding currency. In this research, we tried to contribute in the previous literature for the currency carry trade and its characteristics by using a different approach. Most of the researches that have been conducted in this area concern the risk agents associated with this strategy. However, in our research we investigated the relationship between currency carry trade and two equity indexes, one from the European market (DAX) and one from the American (DJIA). In order to do that, we estimated the returns of the DAX and the Dow Jones Industrial Average (DJIA) as well as the returns of a carry trade index created by the Deutsche Bank, the Deutsche Bank’s G10 Currency Future Harvest index. The returns were estimated for a time period of twenty years (1995-2014). More specific, we examined whether there is granger causality between the returns of carry trade and of DAX/DJIA, whether there is leverage effect on the returns of the same index and finally whether changes in the returns of one of those indexes can affect the subsequent volatility of the other two. For being able to do this examination, we used two different statistical models, the Vector Autoregression (VAR) and the EGARCH [1, 1] model. The first empirical finding suggests that there is granger causal effect from the two equity markets to carry trade, however the carry trade granger cause only to DJIA index. The second finding indicates that there no leverage effect form the past returns to the future volatility for all the three indexes. Finally, the last finding suggests that the volatility process on the returns of one index cannot be determined by changes in the returns of the other two indexes. Keywords: Currency carry, uncovered interest rate parity, DAX, DJIA, G10 currency, granger causality, VAR, EGARCH[1,1]
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Gärtner, Christian. "Liquidität am deutschen Kapitalmarkt : Erholungsfähigkeit der DAX-30-Titel /." Wiesbaden : Dt. Univ.-Verl, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014957082&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA.
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Bolek, Adam. "Volatilitätsschwankungen und DAX-Optionen : Auswirkungen auf Bewertung und Risikomanagement /." Wiesbaden : Deutscher Universitäts-Verlag, 1999. http://aleph.unisg.ch/hsgscan/hm00006891.pdf.
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Venturi, Vanessa. "DAE(di-amil-éter): um novo bio-éter combustível." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/25506.
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De uma forma geral, compostos oxigenados elevam a octanagem das gasolinas e reduzem as emissões de compostos poluentes. As novas especificações para combustíveis ciclo diesel se tornaram extremamente restritivas com relação à redução das emissões. É esperado que os combustíveis para o ciclo diesel tenham alto número de cetano, baixa densidade e baixos teores de aromáticos, poliaromáticos e enxofre. O presente trabalho estuda a síntese do DAE (di-amil éter), um novo bioéter combustível com possibilidade de aditivação na gasolina e no biodiesel. O di-amil éter (DAE) foi produzido em escala semi-piloto, em reator de fluxo e operação contínua. Como reagentes, utilizaram-se álcool isoamílico (insumo proveniente do óleo fúsel) e um corte C5 petroquímico (provedor das olefinas que participam da reação, o 2-metil-1buteno e o 2-metil-2-buteno) e, como catalisador, a resina Amberlyst 36 wet. Quatro sistemas de reação foram utilizados para a determinação das melhores condições operacionais, obtenção de dados cinéticos (ordem de reação e energia de ativação) e termodinâmicos (constante de equilíbrio e entalpia de reação). As condições da reação foram avaliadas a partir de diferentes relações molares álcool isoamílico/olefinas (1,0; 1,2; 1,4; 1,6; e 1,8), temperaturas de reação (30 a 80°C) e velocidades espaciais (1 a 12 h-1). Os parâmetros cinéticos determinados encontram-se próximos aos obtidos na literatura para éteres similares. Ao final do processo de purificação foi obtido DAE com 98% de pureza. O DAE possui baixa viscosidade e quando formulado com biodiesel pode fornecer um combustível com faixa de viscosidade próxima da especificação para o diesel, melhorando o desempenho do biodiesel, além de elevar a entalpia de combustão, quando comparado com o biodiesel puro.In general terms, oxygenated fuels raise the octane of gasoline and reduce polluting compound emissions. New specifications for diesel fuel-cycle have become extremely restrictive regarding the reduction of emissions. It is expected that the diesel fuel-cycle presents a high cetane number, low density and low levels of aromatic, polyaromatic and sulfur compounds. This study presents the synthesis of DAE (diamyl ether) as new possibility for blending bio-ether fuel with gasoline and biodiesel. The diamyl ether (DAE) was produced in semi-pilot scale, in a flow reactor and in continuous operation. Isoamyl alcohol (input from fusel oil) and a C5 petrochemical cut (olefins provider that participate of the reaction, 2-methyl-1-butene and 2-methyl-2-butene) were used as reagents; the resin Amberlyst 36 wet was used as catalyst. Four reaction systems were used to determine the best operating conditions: acquisition of kinetic data (reaction order and activation energy) and thermodynamic (equilibrium constants and reaction enthalpy). The reaction conditions were evaluated by different ratios isoamyl alcohol/olefin (1,0, 1,2, 1,4, 1,6, and 1,8), reaction temperatures (30 to 80°C) and liquid hourly space velocities (1 to 12 h-1). The kinetic parameters determined are close to those obtained in literature for similar ethers. At the end of the purification process, the DAE was obtained with 98% of purity. If formulated with biodiesel fuel, DAE has low viscosity and can provide a range of viscosity close to that specified for diesel, improving the performance of biodiesel and raising the enthalpy of combustion, when compared to pure biodiesel.
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Baranoff, Gilles. "Évaluation en réanimation au centre hospitalier général de Dax." Bordeaux 2, 1991. http://www.theses.fr/1991BOR2M076.
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Oca, Karine. "Intérêt de l'autosurveillance glycémique dans le diabète de type 2 : l'expérience dacquoise." Bordeaux 2, 2001. http://www.theses.fr/2001BOR2M001.
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Berger, Sylvie. "Les moustiques à Dax : les biotopes larvaires et les méthodes de lutte." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25122.
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Marin, Olivier-Gilles. "L'architecture logicielle DARX : adaptation de la résistance aux pannes aux systèmes multi-agents." Le Havre, 2003. http://www.theses.fr/2003LEHA0008.
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Les applications réparties sont très sensibles aux défaillances de sites ou de processus. Ceci est d'autant plus vrai pour les systèmes multi-agents, susceptibles de déployer des multitudes d'agents sur un grand nombre de localisations. Toutefois, la tolérance aux fautes reste un procédé coûteux ; il convient donc de l'appliquer avec discernement. Le travail effectué dans cette thèse porte sur l'adaptation dynamique de la tolérance aux fautes au sein des plates-formes multi-agents. Le but de cette recherche est double : (1) fournir des méthodes de fiabilisation efficaces pour les systèmes multi-agents, ainsi que (2) développer un patron de conception pour des applications réparties déployables à large échelle, que ce soit au niveau du nombre de sites ou du nombre de processus/agents. L'architecture logicielle DARX tend vers ces objectifs en fournissant un support de réplication à la fois transparent, orienté agents, et adaptatif en ce sens qu'il tient compte du contexte d'exécutionDistributed applications are very sensitive to both host and process failures. This is all the truer for multi-agent systems, which are likely to deploy multitudes of agents on a great number of locations. However, fault tolerance involves costly mechanisms; it is thus advisable to apply it wisely. This thesis work relates to the dynamic adaptation of fault tolerance within multi-agents platforms. The aim of this research is double: (1) to provide effective methods for ensuring fail-proof multi-agent computations, (2) to develop a framework for the design of scalable applications, in terms of the number of hosts as well as the number of processes/agents. The DARX framework strives to achieve this twofold objective by providing transparent, agent-specific replication support which adapts to the computation context
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Yettou, Guillaume. "Rôle de la chaperonne d'histone DAXX dans le maintien et l'établissement de l'hétérochromatine." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ054.
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Le rôle fonctionnel des transcrits de l’hétérochromatine péricentromérique reste à ce jour largement incompris chez les eucaryotes supérieurs. Néanmoins, il a été montré que ces transcrits sont soumis à un contrôle très précis, fonction du cycle cellulaire. La régulation de la transcription est fortement contrôlée par la structure de la chromatine qui peut être modifiée localement en changeant la composition biochimique du nucléosome, notamment par l’utilisation des variantes d’histones. L’objectif de ma thèse a été de mieux comprendre le rôle de la protéine chaperonne d’histone DAXX et de sa variante d’histone H3.3 dans la régulation de la transcription des séquences répétées péricentromériques. Par la méthode de purification TAP-TAG, les partenaires spécifiques de DAXX ont été identifiés à partir d’extraits solubles nucléaires de fibroblastes embryonnaires murins. Ces analyses ont mis en évidence que CAF-1, classiquement associé à H3.1, et les facteurs de remodelage de la chromatine ATRX et CHD4 interagissent spécifiquement avec DAXX. Le rôle de ces protéines dans le contrôle de la transcription de l’hétérochromatine péricentromérique a ensuite été mis en évidence par une approche combinant l’interférence ARN et la Q-PCR. Enfin, les résultats suggèrent fortement que ces mécanismes de régulation ont lieu au niveau des corps nucléaires PML. L’ensemble de ces données montre qu’il existe une régulation spatio-temporel très fine de la structure de la chromatine régulant la transcription de l’hétérochromatine péricentromériqueThe functional role of pericentromeric heterochromatin transcripts remains largely unknown in higher eukaryotes. Nevertheless, it has been shown that these transcripts are subject to very precise control, depending on the cell cycle. Regulation of transcription is tightly controlled by chromatin structure that can be modified locally by changing the biochemical composition of the nucleosome, including the use of histone variants. The aim of my thesis was to better understand the role of the histone chaperone protein DAXX and its histone variant H3.3 in the regulation of transcription of pericentromeric repeats. By the method of TAP-TAG purification, DAXX specific partners were identified from soluble nuclear extracts of murine embryonic fibroblasts. These analyzes revealed that CAF-1, classically associated with H3.1, and the chromatin remodeling factors, ATRX and CHD4, specifically interact with DAXX. The role of these proteins in the control of transcription of pericentromeric heterochromatin was then highlighted by an approach combining RNAi and Q-PCR. Finally, the results strongly suggest that these regulatory mechanisms take place at PML nuclear bodies. Taken together, these data show that there is a spatio-temporal regulation of the fine structure of chromatin regulates transcription of pericentromeric heterochromatin
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BRASIL, CPRM SERVIÇO GEOLÓGICO DO. "Atlas pluviométrico do Brasil: equações, intensidade-duração-frequência: município Conchas, SP, estação pluviográfica Pereiras, códigos 02347006 (ANA) e EA-010R (DAEE), estação pluviométrica Conchas, códigos 02348003 (ANA) e E5-001 (DAEE)." CPRM, 2016. http://rigeo.cprm.gov.br/xmlui/handle/doc/17535.
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Programa Geologia do Brasil. Levantamento da Geodiversidade Carta de suscetibilidade a movimentos gravitacionais de massa e inundação
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Feng, Tianshu. "Characterisation of 2-oxoglutarate- and fe(II)-dependent oxygenases targeting the protein synthesis apparatus." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:406a311b-dae6-48c6-9785-1e2f0b889e45.
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Members of the 2-oxoglutarate (2OG)- and Fe(II)-dependent oxygenase (2OG oxygenase) superfamily catalyse a wide range of oxidative reactions in biology. 2OG oxygenases require Fe(II) and atmospheric oxygen for their activity, and couple substrate oxidation with the decarboxylation of 2OG into succinate and carbon dioxide. There are more than sixty known 2OG oxygenases in the human genome; they modify small molecules, nucleic acids and proteins implicated in diverse biological processes. Importantly, the seemingly disparate functions of 2OG oxygenases often converge to regulate gene expression. 2OG oxygenases have been shown to affect epigenetic reprogramming, chromatin remodelling, transcription factor activity and mRNA splicing. Emerging evidence indicates that 2OG oxygenases are also involved in the translational control of gene expression. Oxygenases TYW5, ALKBH8, ALKBH5 and FTO were found to catalyse modifications of tRNA and mRNA. The work in this thesis extends these observations by demonstrating that 2OG oxygenase-catalysed protein hydroxylations also play an important role in protein synthesis. The catalytic activities of two oxygenases belonging to the JmjC-only family, NO66 and JMJD4, are described. NO66 catalyses the histidinyl hydroxylation of 60S ribosomal subunit protein L8. NO66 is part of a conserved group of ribosomal protein hydroxylases that can be traced back to prokaryotes. JMJD4 is a lysyl hydroxylase of eRF1, the eukaryotic release factor responsible for translation termination. The hydroxylation of eRF1 takes place on a conserved NIKS motif important for release factor activity, and promotes effcient translational termination. JMJD4 is further implicated in cell growth and cancer, though the link between its activity and tumourigenesis remains to be determined. These results highlight the potential of 2OG oxygenases as regulators of protein synthesis, and further extend the scope of 2OG oxygenase function. The small molecule inhibition of 2OG oxygenases presents a novel therapeutic possibility targeting translational control in cancer and other diseases.
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Sautter, Jörg. "Messung und Prognose von Volatilitäten am Beispiel des DAX-Index /." Frankfurt am Main : Bankakad.-Verl, 1996. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=007217619&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Barenhoff, Patrick A. "Die Lageberichterstattung der DAX-Konzerne unter dem Einfluss des Bilanzrechtsreformgesetzes /." Baden-Baden : Nomos, 2009. http://d-nb.info/990952339/04.
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Barenhoff, Patrick A. "Die Lageberichterstattung der DAX-Konzerne unter dem Einfluss des Bilanzrechtsreformgesetzes." Baden-Baden Nomos, 2008. http://d-nb.info/990952339/04.
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Chirio, Jean. "Activité du SMUR dans le nouveau centre hospitalier de Dax." Bordeaux 2, 1989. http://www.theses.fr/1989BOR25284.
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Burke, Alexander. ""Dae Scotsmen Dream o 'lectric Leids?" Robert Crawford's Cyborg Scotland." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3272.
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This thesis applies a Cybernetic interpretation to a selection of poetry by the Scottish Informationist poet Robert Crawford, drawn mostly from two collections: A Scottish Assembly (1990) and Sharawaggi: Poems in Scots (1990). Crawford is contextualized by observing the poetic influences of Robert Burns, John Davidson, and Hugh MacDiarmid, as well as the philosophical influence of George Elder Davie’s The Democratic Intellect. This paper argues that, in response to the Two Cultures hypothesis put forth by C. P. Snow and the widely-held belief that Scotland is irrevocably fractured, the shifting boundaries of the many disparate Scottish cultures are mediated by technologies of communication within A Scottish Assembly, updating both Scotland’s identity and its cultural canon not by merging these cultures into a single Universal Scot, but by holding them in tension—and Sharawaggi is observed as a means of grounding the languages and peoples of Scotland within the landscape.
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Franck-Miclo, Alicia. "Développement d'une stratégie thérapeutique anti-apoptotique contre les lésions d'ischémie-reperfusion myocardique." Thesis, Montpellier 1, 2012. http://www.theses.fr/2012MON13505/document.
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L'infarctus du myocarde (IDM) est consécutif à une occlusion coronaire provoquant une ischémie prolongée. La taille de l'infarctus est le déterminant majeur de la récupération du myocarde et de la survie du patient. La reperfusion coronaire la plus précoce (par thrombolyse ou angioplastie) est reconnue comme étant le seul traitement recommandé. Cependant, malgré les effets bénéfiques, la reperfusion s'accompagne d'effets délétères appelés « lésions de reperfusion ». Récemment, l'efficacité du postconditionnement ischémique (PostC) a été démontrée en clinique. Il permet, lorsqu'il est utilisé au cours de l'angioplastie primaire ou de sauvetage, de réduire significativement la taille de l'infarctus. L'application du protocole de PostC reste cependant limitée aux patients admis dans les centres d'angioplastie, ce qui exclut tous les patients thrombolysés. Afin d'améliorer la cardioprotection, il est nécessaire de déterminer la fenêtre thérapeutique temporelle optimale d'administration du PostC. De plus, il est nécessaire de développer des stratégies thérapeutiques nouvelles, adjuvants de la reperfusion, qui pourront être administrées dès que le diagnostic d'IDM est posé. L'objectif de notre travail a donc été d'étudier l'influence du délai d'application du PostC sur l'efficacité de cardioprotection dans un modèle murin d'ischémie-reperfusion et de rechercher des substances pharmacologiques cardioprotectrices. Nos travaux révèlent que l'efficacité du PostC est maintenue s'il est appliqué les 30 premières minutes après le début de la reperfusion. D'autre part, nous avons évalué le potentiel thérapeutique de peptides inhibiteurs ciblant l'apoptose responsable de la mort cellulaire au cours de l'ischémie-reperfusion. L'utilisation de peptides Tat-BH4 et Pip2b-BH4 pour le traitement des lésions d'ischémie-reperfusion myocardique a fait l'objet d'une étude preuve-de-concept in vivo. Les constructions peptidiques inhibant l'interaction FAS-DAXX, injectées en intraveineuse au moment de la reperfusion, induisent une diminution de 50% de la taille d'infarctus et de l'apoptose. Ils ont fait l'objet d'un dépôt de brevet car ils constituent des outils pharmacologiques à haut potentiel thérapeutiqueMyocardial infarction (MI) results from a coronary occlusion leading to severe ischemia. Infarct size is a major determinant of myocardial salvage and mortality. Prompt revascularization (either by thrombolysis or primary angioplasty) is recommended for AMI patients but leads to deleterious effects called "reperfusion injury". Recently, ischemic postconditioning (PostC) efficiency has been reported in patients. However, its application during primary angioplasty is limited to patients admitted in angioplasty centers thereby excluding thrombolysed patients. In order to improve cardioprotection, it is necessary to define the time window for optimal cardioprotection and to develop new pharmacological strategies for AMI patients. Our work, using an in vivo mouse model of ischemia-reperfusion, shows that PostC efficiency is maintained if applied the first 30 minutes after the onset of reperfusion. Furthermore, we evaluated the therapeutic potential of peptide inhibitors targeting apoptosis, which is responsible for cell death during ischemia-reperfusion. As a proof-of-concept study, the cardioprotective effects of Tat-BH4 and Pip2b-BH4 peptidic constructs have been revealed in vitro and in vivo. The peptidic constructs targeting FAS-DAXX interaction, injected intravenously as a single bolus at the time of reperfusion, reduced by 50% both infarct size and apoptosis. These pharmacological tools have been patented due to their high therapeutic potential
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Stoyanov, Miroslav Karolinov. "Optimal Linear Feedback Control for Incompressible Fluid Flow." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/33454.
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Linear feedback control is considered for large systems of differential algebraic equations
arising from discretization of saddle point problems. Necessary conditions are derived by
applying the Maximum Principle and have the form of constrained Riccati equations. We
consider two approaches for solving the feedback control problem as well as practical numerical
methods. Numerical studies using examples derived from a constrained heat equation
and Stokes equation confirms the effectiveness of the approaches we consider.Master of Science
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Klein, Holger. "Internal corporate venturing : die Überwindung von Innovationsbarrieren in DAX-100-Unternehmen /." Wiesbaden : Dt. Univ.-Verl, 2002. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009816819&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
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Carlsson, Christian. "Profiting from serial correlation : Constructing a trading strategy on the DAX." Thesis, Umeå universitet, Nationalekonomi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138149.
Full textAbstract:
This paper studies how technical analysis has been used throughout historyand constructs a technical trading strategy to be used in a computer algorithm.The strategy is based on a linear regression indicator and aims to prot fromthe assumption that markets, in this case the DAX, has some degree of serialcorrelation in daily price-movements. The strategy developed in this paper doesbeat a buy and hold with a substantial margin. Further, I test the validity of theseresults by simulating two different sets of random stock-paths using monte-carlosimulations; one following a geometric Brownian motion and the other a wienerprocess with serial correlation. I nd that the strategy based on a linear regressionhas signicantly higher returns than a buy and hold strategy over the same timeperiod and that the results generated by the strategy on the DAX give some degreeof evidence for serial correlation in daily prices on the DAX.