Journal articles on the topic 'Daihai Basin'

Exploring eco-environmental quality dynamics in the Daihai Lake Basin has significant implications for the conservation of ecological environments in the semi-arid and arid regions of northern China. Based on the Google Earth Engine (GEE) platform, the remote sensing ecological index (RSEI) was constructed by coupling Landsat SR remote sensing data from 1985 to 2022. The spatial significance of the RSEI was analyzed using linear regression equations and an F-test. The spatial correlation, distribution characteristics, and driving factors behind the RSEI were explored using Moran’s index and a geodetector. The results indicated that (1) the RSEI was appropriate for evaluating eco-environmental quality in the Daihai Lake Basin. (2) From 1985 to 2022, the eco-environmental quality of the Daihai Lake Basin exhibited a positive trend but remained subpar. (3) A positive spatial autocorrelation was demonstrated for eco-environmental quality with increasing spatial aggregation. (4) Significant eco-environmental quality degradation (slope < 0) occurred primarily in Sanyiquan Town in the northeastern region of the basin and in Tiancheng Township in the southeastern region. Conversely, a notable improvement (slope > 0) was predominantly observed in Yongxing and Liusumu in southwestern Daihai. (5) The improvement in the ecological environment of the Daihai Lake Basin was primarily attributed to an increase in NDVI and WET and a decrease in NDBSI and LST. The interaction between NDVI and LST had the greatest explanatory power for the ecological environment. Among the external driving factors, DEM (elevation) was the dominant factor in the RSEI and had the strongest explanatory power. The interaction between DEM and LST was the most significant, and the driving factors were enhanced. This study provided a theoretical basis for the sustainable development of the Daihai Lake Basin, which is crucial for the local ecological environment and economic development.

Green development accounting provides the theoretical basis and data support for national or regional ecological civilization constructions. The Daihai Basin, located in Ulanqab City, Inner Mongolia Autonomous Region, is not only an important ecological barrier in the region but also one of the 179 nationally important wetlands under the “China Wetland Conservation Action Plan”. It plays a crucial role in maintaining regional ecological balance, providing ecological services such as water conservation, climate regulation, and biodiversity protection. Taking Daihai Basin as the study area, an accounting system of Green Gross Domestic Product (GGDP), Gross Ecosystem Product (GEP), and Gross Economic–Ecological Product (GEEP) was constructed to explore the temporal variation characteristics of GGDP, GEP, and GEEP in the study area from 1989 to 2022. The results were as follows: (1) During the study period, the overall GGDP in Daihai Basin showed an increasing trend, with an increase of CNY 3.812 billion in the past 30 years, of which GGDP increased from 1989 to 2011 and decreased from 2011 to 2022. In addition to GDP, the ecological damage cost was the most important factor influencing GGDP in the Daihai Basin, and the most significant one is the ecological damage to the wetland. (2) The GEP in the study area decreased, with a decrease of CNY 1.066 billion in the past 30 years. However, the conversion value of “Two Mountains” increased year by year. During the study period, the ecological regulation service value, which was dominated by climate regulation and water conservation, decreased year by year. (3) The GEEP in the study area showed a fluctuating change, with an overall upward trend, reaching a maximum of CNY 9.011 billion in 2011. (4) Except for 2011, during the study period, GEEP > GEP > GGDP in Daihai Basin, but the main driving factors of the three indicators were different, and the variation trends with time were different. The results of this research can provide a decision-making basis for the high-quality development of the Daihai Basin and provide reference cases for the green development accounting of other basins.

There are a large number of lakes with beaded distribution in the semi-arid areas of the Inner Mongolian Plateau, and some of them have degraded or even disappeared during the past three decades. We studied the reasons of the disappearance of these lakes by determining the way of replenishment of these lakes and the impact of the natural-social environment of the basin, with the aim of saving these gradually disappearing lakes. Based on remote sensing image and hydrological analysis, this paper studied the recharge of Daihai Lake and Huangqihai Lake. The deep learning method was used to establish the time-series of lake evolution. The same method was combined with the innovative woodland and farmland extraction method to set up the time-series of ground classification composition in the basins. Using relevant survey data, combined with soil water infiltration test, water chemical, and isotopic signature analysis of various water bodies, we found that the Daihai Lake area is the largest in dry season and the smallest in rainy season and the other lake is not satisfied with this phenomenon. In addition, we calculated the specific recharge and consumption of the study basin. These experiments indicated that the exogenous groundwater is recharged directly through the faults at the bottom of Daihai Lake, while the exogenous groundwater is recharged in Huangqihai Lake through rivers indirectly. Large-scale exploitation of groundwater for agricultural irrigation and industrial production is the main cause of lake degradation. Reducing the extraction of groundwater for agricultural irrigation is an important measure to restore lake ecology.

<em>This study investigates trends in the evolution of the coupling state of the man-land relationship and the primary barrier by using a model of the coordination and coupling of the man-land link to the regional system and the Ulanqab in the Daihai Basin as a topic. The next conclusions were reached: (1) Regional development intensity index, resource and environment level index, and trend in collaborative development after 2015 all demonstrated a varying and intertwined growing tendency. (2) After 2004, the coupling degree reached high-quality coupling, and after showing a weak upward trend, the coupling degree reached good coordination in 2012. (3) Effective irrigated area, total area of crops planted, effective irrigated area, and total population at the end of the year were the key barrier variables;</em><em>(</em><em>4</em><em>)</em><em> It is advised to support integrated urban and rural growth, uphold green development, and improve the hub economy&#39;s agglomeration function.</em>

PT. Daihan global merupakan salah satu perusahaan yang bergerak di bidang tekstil (garment) tepatnya memproduksi bra dan panty masih menggunakan program aplikasi spreadsheet dalam pengolahan data hasil produksi sehinggamengalami kendala dalam proses penyajian laporan. Perancangan sistem informasi hasil produksi dalam penelitian ini menggunakan teknologi jaringanc/ient servertwo tier denganmenggunakan SQL Server 2000 sebagai back-end dan Visual Basic 6.0 sebagai front-end.

Young aboriginals are emigrating from their homelands to cities to become laborers working in basic production-related jobs, hampering the sustainability of the alpine tribes. This study examines the critical demands of Tungpu Daigaz, an alpine tribe in Taiwan, through in-depth interviews and questionnaires. Based on the analytical results, we propose that for the alpine tribe, the government should further improve transportation, add value to featured tribal products, and close the consensus gap among tribes. Whereas previous studies have recommended strategies, including loans and human resource training, we believe that the improvements should be accomplished through acquisition, transmission, creation, and use. This study establishes a KBD model to construct industrial knowledge for Tungpu Daigaz. Knowledge translation is carried out by integrating new hunter knowledge with tribal opinions. Knowledge transmission is then performed to encourage group learning. Long-term development depends on knowledge creation by tribes. We suggest that the government build a hub for the industries connecting Tungpu hot spring with the tribal resources and enhance sustainable development through tribal mountain guides and the hunting culture of Tungpu Daigaz. The knowledge-hunting developmental model can balance Tungpu Daigaz while developing the culture and wisdom of alpine tribes, solve the problems of tribal development, and ensure environmental protection and sustainable development. This study establishes a circulation system of new hunter knowledge based on a comprehensive understanding of the demands of local development for knowledge creation and skill integration, cooperation with external expertise and young innovative knowledge of tribal youths, and co-management with self-media. This novel KBD model can promote tribe sustainability.

<strong>Tsakure: </strong><em>Fannin kamannin Sauti fanni ne da ke lura da yadda sautin magana ke tafiya daga bakin wanda ya furta zuwa ga mai sauraro. Don haka fanni ne da ke ƙalailaice igiyar silalin sauti tare da awon amo da ƙarajin sauti da kuma tsawon lokacin da sautin ke ɗauka a lokacin da aka furta shi. Bugu da ƙari, yana fayyace maginan sauti (Formants) da ke ƙunshe cikin kowace ƙwayar sauti da aka furta. Ana kuma nuna kadadar sauti ta amfani da na&rsquo;urar taswirar sauti (Soundwave and Spectogram). Kasancewar kowane harshe da nasa tsarin sauti, wannan ya sa ake jin wasu Yarbawa mazauna garin Gusau na furta baƙaƙen Hausa masu ƙugiya ba daidai ba. An yi amfani da manhajar Praat wajen ƙalailaice aiki, an kuma naɗi muryar masu bayar da bayani shida, maza uku mata uku. Binciken ya gano cewa Yarbawa mazauna garin Gusau ba sa iya furta baƙaƙen /ɓ/, da /ɗ/, da /&rsquo;ya/ sukan musanyan su da /b/, da /d/, da /y/. Wannan kuma bai rasa nasaba da rashin waɗancan ƙwayoyin a harshen Yarbanci. Bugu da ƙari, an gano cewa suna iya furta baƙin /ƙ/ da kyau. An yi la&rsquo;akari da wannan ta hanyar ƙalailaice kamannin sautin kowane baƙi daga cikin jerin kalmomin da ke ɗauke da baƙaƙe masu ƙugiya waɗanda masu bayar da bayani suka furta.</em>

Seismic sedimentology and sequence stratigraphy, as emerging interdisciplinary fields, demonstrate unique advantages in characterizing seismic geomorphological responses of various system tracts within the stratigraphic frameworks of rift lacustrine basins. Focusing on the Paleogene Dainan Formation in the Gaoyou Sag of the Subei Basin, eastern China, this study integrates seismic termination patterns, sedimentary cyclicity analysis, and well-to-seismic calibration to subdivide the formation into three third-order sequences containing lowstand (LST), transgressive (TST), and highstand (HST) system tracts. The distribution of five distinct sedimentary facies exhibits pronounced sub-tectonic zonations controlled by the basin’s architecture and structural evolution, with steep slope zones dominated by nearshore subaqueous fan–fan delta complexes, gentle slopes developing normal deltaic systems, and deep-semi-deep lacustrine facies with slump turbidite fans concentrated in depositional centers. Through a novel application of 90° phase adjustment, spectral decomposition, and multi-attribute fusion techniques, the relationship between seismic amplitude attributes and lithologies are established via seismic lithology calibration. Detailed sequence evolution analyses and seismic geomorphological interpretation systematically elucidate the spatio-temporal evolution of depositional systems within different system tracts in rift lacustrine basins, providing a novel methodological framework for sequence stratigraphic analysis in continental rift settings.

Research on the characterization of ground motion intensity and damage of underground structures is limited, while reasonable selection of ground motion intensity measures and structural damage measures is a crucial prerequisite for structural seismic performance evaluation. In this study, a two-dimensional finite element model of soil and structures was established based on the Daikai subway station in Japan. Through incremental dynamic analysis, 32 ground motion intensity measures and seven structural damage measures were comprehensively evaluated from seven properties, including efficiency, practicality, proficiency, scaling robustness, relativity, hazard computability, and sufficiency. According to the analysis results, the purpose and significance of each property during measure optimization were hierarchically sorted out. The results show that peak ground acceleration, acceleration spectrum intensity, and sustained maximum acceleration are recommended as ground motion intensity measures, while maximum inter-story drift ratio, column end displacement angle, and two-parameter measures are recommended as the structural damage measures for seismic performance evaluation of the shallow-buried subway station. Furthermore, measure optimization approaches are proposed as follows: the basic selection of IMs should satisfy scaling robustness, hazard computability, and sufficiency to site condition; the optimal selection of IMs is suggested to be evaluated mainly through efficiency, practicality and proficiency, and verified through relativity and relative sufficiency between IMs. The optimal selection of DM is suggested to be evaluated through four properties, including efficiency, practicality, proficiency, and relativity.

The Little East Lake Formation represents a spectrum of Late Ordovician (Ashgill) nearshore environments. These physical environments are characterized by a variety of quartz- and feldspar-rich sandstone and slate. Depositional environments include neritic nearshore, beach, tidal flat, and alluvial(?). The beach and neritic nearshore environments contain a variety of fossil invertebrates. The majority of the brachiopod fauna is confined to two taxa: Eodinobolus rotundus Harper, 1984, and Dalmanella testudinaria ripae Mitchell, 1978 (in Cocks, 1978). Some of the specimens have been broken and abraded suggesting transport within the beach swash zone. Gastropods include Lophospira cf. L. milleri (Hall), Lophospira(?), Trochonemella cf. T. notabilis (Ulrich and Scofield), and Daidia cerithioides (Salter). Tidal-flat environment contains the trace fossils Palaeophycus and Planolites.The Late Ordovician (Caradoc and Ashgill) sedimentary basins developed subsequent to the collisional Taconian orogeny, wherein an arc accreted to the eastern Laurentian margin. Prior paleomagnetic reconstructions place the southeastern continental margin of Laurentia at approximately 25° south latitude during the Late Ordovician. Using these reconstructions, the siliciclastic Ashgill rocks discussed here would have been deposited in an elongated, northeast-trending basin on the southeastern Laurentian margin. The fauna developed along this margin, but in contrast to possibly adjacent Irish and Scottish assemblages, was located in much shallower water.

Abstract Background: Overexpression of CD123 (IL-3Rα receptor) is a hallmark of blastic plasmacytoid dendritic cell neoplasm (BPDCN), thus making this antigen an attractive target for the development of new therapeutics. IMGN632 is a CD123-targeting antibody-drug conjugate (ADC) comprising a novel anti-CD123 antibody coupled, via a highly-stable peptide linker, to a unique DNA-alkylating cytotoxic payload of the recently developed IGN (indolinobenzodiazepine pseudodimer) class. Preclinically, IMGN632 has demonstrated potent activity against BPDCN cells with remarkable sensitivity of patient derived xenografts to IMGN632 (Blood 2018 132:3956). IMGN632 has demonstrated a wide therapeutic index in vitro and in vivo (PMIDs: 29661755, 30361418). Importantly IMGN632 has demonstrated favorable safety profile and has demonstrated evidence of promising efficacy in patients with BPDCN (ASH 2020: Blood 2020, vol 136, suppl 1, 11-13) and AML (ASH 2019: Blood 2019, vol 134, suppl 1, 734). Based on this data, IMGN632 was granted FDA Breakthrough Therapy Designation for BPDCN (Oct 2020). Initial experience with 3 frontline BPDCN patients showed clinical complete remissions (CRc) in all three patients. Subsequently an FDA-aligned pivotal cohort enrolling frontline BPDCN patients has been added to this study. Methods: This study is currently enrolling two expansion cohorts for adults with CD123 positive BPDCN. The pivotal cohort is enrolling patients with frontline/untreated (no prior systemic therapy) BPDCN who do not have CNS involvement and meet other basic eligibility. This cohort is designed to support an application for FDA approval for IMGN632 in patients with BPDCN. An additional cohort is enrolling patients with relapsed/refractory BPDCN, which may have had up to 3 prior lines of therapy, including CD123-targeted therapies and prior hematopoietic stem cell transplant (after 120 days) and may have CNS involvement (if cleared with intrathecals), but who must not have prior history of veno-occlusive disease of the liver, or history of grade 4 capillary leak syndrome or non-cardiac grade 4 edema, and other eligibility. Both cohorts are enrolling patients at the RP2D (0.045 mg/kg IV Q 3 weeks) in the US and EU (NCT03386513, https://BPDCNtrial.com). Disclosures Pemmaraju: Clearview Healthcare Partners: Consultancy; Cellectis S.A. ADR: Other, Research Funding; Novartis Pharmaceuticals: Consultancy, Other: Research Support, Research Funding; Protagonist Therapeutics, Inc.: Consultancy; Celgene Corporation: Consultancy; MustangBio: Consultancy, Other; Plexxicon: Other, Research Funding; Blueprint Medicines: Consultancy; Dan's House of Hope: Membership on an entity's Board of Directors or advisory committees; Abbvie Pharmaceuticals: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other, Research Funding; Affymetrix: Consultancy, Research Funding; ASCO Leukemia Advisory Panel: Membership on an entity's Board of Directors or advisory committees; Incyte: Consultancy; Daiichi Sankyo, Inc.: Other, Research Funding; Roche Diagnostics: Consultancy; DAVA Oncology: Consultancy; Aptitude Health: Consultancy; CareDx, Inc.: Consultancy; HemOnc Times/Oncology Times: Membership on an entity's Board of Directors or advisory committees; Stemline Therapeutics, Inc.: Consultancy, Membership on an entity's Board of Directors or advisory committees, Other, Research Funding; Springer Science + Business Media: Other; Sager Strong Foundation: Other; ASH Communications Committee: Membership on an entity's Board of Directors or advisory committees; LFB Biotechnologies: Consultancy; Bristol-Myers Squibb Co.: Consultancy; Samus: Other, Research Funding; ImmunoGen, Inc: Consultancy; Pacylex Pharmaceuticals: Consultancy. Montesinos: Pfizer: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Tolero Pharmaceutical: Consultancy; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Janssen: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Incyte: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Forma Therapeutics: Consultancy; Karyopharm: Membership on an entity's Board of Directors or advisory committees, Research Funding; Stemline/Menarini: Consultancy; Sanofi: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Teva: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Novartis: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Glycomimetics: Consultancy; Daiichi Sankyo: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Agios: Consultancy; AbbVie: Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Astellas Pharma, Inc.: Consultancy, Honoraria, Other: Advisory board, Research Funding, Speakers Bureau. Lane: Qiagen: Consultancy, Honoraria; N-of-One: Consultancy, Honoraria; Stemline Therapeutics: Research Funding; AbbVie: Research Funding. Sweet: AROG: Membership on an entity's Board of Directors or advisory committees; Astellas: Consultancy, Membership on an entity's Board of Directors or advisory committees; Gilead: Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; Bristol Meyers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees. Wang: Kite Pharmaceuticals: Consultancy, Honoraria, Other: Advisory Board; Mana Therapeutics: Consultancy, Honoraria; Kura Oncology: Consultancy, Honoraria, Other: Advisory board, steering committee, Speakers Bureau; Stemline Therapeutics: Consultancy, Honoraria, Other: Advisory board, Speakers Bureau; Pfizer: Consultancy, Honoraria, Other: Advisory Board, Speakers Bureau; DAVA Oncology: Consultancy, Speakers Bureau; GlaxoSmithKline: Consultancy, Honoraria, Other: Advisory Board; Genentech: Membership on an entity's Board of Directors or advisory committees; AbbVie: Consultancy, Membership on an entity's Board of Directors or advisory committees; Astellas: Consultancy, Membership on an entity's Board of Directors or advisory committees; BMS/Celgene: Membership on an entity's Board of Directors or advisory committees; Jazz Pharmaceuticals: Consultancy, Honoraria, Other: Advisory Board; Novartis: Consultancy, Honoraria, Other: Advisory Board; Takeda: Consultancy, Honoraria, Other: Advisory board; Rafael Pharmaceuticals: Other: Data safety monitoring committee; Gilead: Consultancy, Honoraria, Other: Advisory board; Daiichi Sankyo: Consultancy, Honoraria, Other: Advisory board; PTC Therapeutics: Consultancy, Honoraria, Other: Advisory board; Genentech: Consultancy; MacroGenics: Consultancy. Deconinck: Imunogen: Membership on an entity's Board of Directors or advisory committees; Stemline Therapetutics: Membership on an entity's Board of Directors or advisory committees; Chugai: Research Funding; Novartis: Research Funding; Pfizer: Other: Travel Grants, Research Funding; Abbevie: Research Funding. Rizzieri: AbbVie: Membership on an entity's Board of Directors or advisory committees; AROG: Membership on an entity's Board of Directors or advisory committees; Bayer: Membership on an entity's Board of Directors or advisory committees; Sanofi: Membership on an entity's Board of Directors or advisory committees; Teva: Membership on an entity's Board of Directors or advisory committees; Acrotech: Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Stemline: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Incyte: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Kite: Honoraria, Speakers Bureau; Karyopharm: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene: Membership on an entity's Board of Directors or advisory committees; Celltrion: Membership on an entity's Board of Directors or advisory committees; Gilead: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Mustang: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees; Jazz: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Pfizer: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Amgen: Honoraria; Pharmacyclics: Honoraria. Walter: Agios Pharmaceuticals, Inc.: Consultancy, Research Funding; Amgen, Inc.: Consultancy, Research Funding; Amphivena Therapeutics, Inc.: Current equity holder in publicly-traded company; Aptevo Therapeutics, Inc.: Consultancy, Research Funding; Arog Pharmaceuticals, Inc.: Research Funding; Astellas Pharma US, Inc.: Consultancy; BioLineRx, Ltd.: Consultancy, Research Funding; Boston Biomedical, Inc.: Consultancy; Bristol Myers Squibb, Inc.: Consultancy; Celgene, Inc.: Consultancy, Research Funding; Genentech, Inc.: Consultancy; GlaxoSmithKline, Inc.: Consultancy; ImmunoGen, Inc.: Research Funding; Janssen Global Services, LLC: Consultancy; Janssen Research &amp; Development, Inc.: Research Funding; Jazz Pharmaceuticals, Inc.: Consultancy, Research Funding; Kite Pharma, Inc.: Consultancy; Kronos Bio, Inc.: Consultancy; Kura Oncology, Inc.: Research Funding; Macrogenics, Inc.: Research Funding; New Link Genetics: Consultancy; Pfizer, Inc.: Consultancy, Research Funding; Race Oncology Ltd.: Consultancy; Selvita: Research Funding; Stemline Therapeutics, Inc.: Research Funding. Aribi: Seagen: Consultancy. Levy: Bristol Myers Squibb: Consultancy, Honoraria, Other: Promotional speaker, Speakers Bureau; Amgen Inc.: Consultancy, Honoraria, Other: Promotional speaker, Speakers Bureau; Janssen Pharmaceuticals: Consultancy, Honoraria, Other: Promotional speaker, Speakers Bureau; Takeda: Consultancy, Honoraria, Other: Promotional speaker, Speakers Bureau; Beigene: Consultancy, Honoraria, Speakers Bureau; Novartis: Consultancy, Other: Promotional speaker; AstraZeneca: Consultancy, Honoraria, Speakers Bureau; Jazz Pharmaceuticals: Consultancy, Honoraria, Speakers Bureau; Morphosys: Consultancy, Honoraria, Other: Promotional speaker, Speakers Bureau; Seattle Genetics: Consultancy, Honoraria, Other: Promotional speaker, Speakers Bureau; Karyopharm: Consultancy, Honoraria, Other: Promotional speaker, Speakers Bureau; GSK: Consultancy, Other: Promotional speaker; TG Therapeutics: Consultancy, Honoraria, Speakers Bureau; Gilead Sciences, Inc.: Consultancy, Honoraria, Speakers Bureau; Epizyme: Consultancy, Other: Promotional speaker; AbbVie: Consultancy, Honoraria, Other: Promotional speaker, Speakers Bureau; Dova: Consultancy, Other: Promotional speaker. Martinelli: Pfizer: Consultancy, Speakers Bureau; Stemline Therapeutics: Consultancy; Abbvie: Consultancy; Jazz Pharmaceuticals: Consultancy; Celgene /BMS: Consultancy, Speakers Bureau; Incyte: Consultancy; Roche: Consultancy; Astellas: Consultancy, Speakers Bureau; Daichii Sankyo: Consultancy. Erba: AbbVie Inc; Agios Pharmaceuticals Inc; Bristol Myers Squibb; Celgene, a Bristol Myers Squibb company; Incyte Corporation; Jazz Pharmaceuticals Inc; Novartis: Speakers Bureau; AbbVie Inc: Other: Independent review committee; AbbVie Inc; Agios Pharmaceuticals Inc; ALX Oncology; Amgen Inc; Daiichi Sankyo Inc; FORMA Therapeutics; Forty Seven Inc; Gilead Sciences Inc; GlycoMimetics Inc; ImmunoGen Inc; Jazz Pharmaceuticals Inc; MacroGenics Inc; Novartis; PTC Therapeutics: Research Funding; AbbVie Inc; Agios Pharmaceuticals Inc; Astellas; Bristol Myers Squibb; Celgene, a Bristol Myers Squibb company; Daiichi Sankyo Inc; Genentech, a member of the Roche Group; GlycoMimetics Inc; Incyte Corporation; Jazz Pharmaceuticals Inc; Kura Oncology; Nov: Other: Advisory Committee. Konopleva: KisoJi: Research Funding; Novartis: Other: research funding pending, Patents &amp; Royalties: intellectual property rights; Rafael Pharmaceuticals: Other: grant support, Research Funding; Sanofi: Other: grant support, Research Funding; Ablynx: Other: grant support, Research Funding; Agios: Other: grant support, Research Funding; Eli Lilly: Patents &amp; Royalties: intellectual property rights, Research Funding; Stemline Therapeutics: Research Funding; AstraZeneca: Other: grant support, Research Funding; Ascentage: Other: grant support, Research Funding; Calithera: Other: grant support, Research Funding; Reata Pharmaceuticals: Current holder of stock options in a privately-held company, Patents &amp; Royalties: intellectual property rights; Cellectis: Other: grant support; Forty Seven: Other: grant support, Research Funding; F. Hoffmann-La Roche: Consultancy, Honoraria, Other: grant support; Genentech: Consultancy, Honoraria, Other: grant support, Research Funding; AbbVie: Consultancy, Honoraria, Other: Grant Support, Research Funding. Kantarjian: Aptitude Health: Honoraria; Novartis: Honoraria, Research Funding; Jazz: Research Funding; Immunogen: Research Funding; Pfizer: Honoraria, Research Funding; KAHR Medical Ltd: Honoraria; NOVA Research: Honoraria; Ipsen Pharmaceuticals: Honoraria; Taiho Pharmaceutical Canada: Honoraria; Astellas Health: Honoraria; Precision Biosciences: Honoraria; Daiichi-Sankyo: Research Funding; BMS: Research Funding; Astra Zeneca: Honoraria; Ascentage: Research Funding; Amgen: Honoraria, Research Funding; AbbVie: Honoraria, Research Funding. Wang: Immunogen: Current Employment. Malcolm: Immunogen: Current Employment. Zweidler-McKay: ImmunoGen: Current Employment. DeAngelo: Abbvie: Research Funding; GlycoMimetics: Research Funding; Pfizer: Consultancy; Shire: Consultancy; Incyte Corporation: Consultancy; Blueprint Medicines Corporation: Consultancy; Amgen: Consultancy; Agios: Consultancy; Autolus: Consultancy; Takeda: Consultancy; Jazz: Consultancy; Forty-Seven: Consultancy; Novartis: Consultancy, Research Funding. Daver: Pfizer: Consultancy, Research Funding; Novartis: Consultancy; FATE Therapeutics: Research Funding; Gilead Sciences, Inc.: Consultancy, Research Funding; Sevier: Consultancy, Research Funding; Hanmi: Research Funding; Abbvie: Consultancy, Research Funding; Daiichi Sankyo: Consultancy, Research Funding; Trovagene: Consultancy, Research Funding; Amgen: Consultancy, Research Funding; Genentech: Consultancy, Research Funding; Astellas: Consultancy, Research Funding; Glycomimetics: Research Funding; Novimmune: Research Funding; ImmunoGen: Consultancy, Research Funding; Trillium: Consultancy, Research Funding; Bristol Myers Squibb: Consultancy, Research Funding; Jazz Pharmaceuticals: Consultancy, Other: Data Monitoring Committee member; Dava Oncology (Arog): Consultancy; Celgene: Consultancy; Syndax: Consultancy; Shattuck Labs: Consultancy; Agios: Consultancy; Kite Pharmaceuticals: Consultancy; SOBI: Consultancy; STAR Therapeutics: Consultancy; Karyopharm: Research Funding; Newave: Research Funding.

AbstractArid area is very sensitive to global warming and are extremely vulnerable to climate change. Moreover, the water resources system in the arid area is fragile and will undergo tremendous changes with climate change. Therefore, the interaction of climate and hydrology in arid area has an important impact on the formation of regional microclimate and hydrological changes. Daihai Lake is a typical closed inland lake in arid area of China, and a key area for ecological protection in North China. In this paper, WRF-Hydro model is used to simulate the climate hydrological coupling situation of Daihai Basin from 1980 to 2020, and the coupling results are verified and calibrated by meteorological statistics, runoff calculation and remote sensing analysis. Based on the synopsis of climate and hydrology in the past 40 years, the causes and future trends of the hydrological elements in Daihai Basin are analyzed. Through the analysis, it is found that the interannual variation of precipitation in Daihai Basin is sharp, with 401.75 mm as the average from 1980 to 1994; and drastic fluctuations from 1995 to 2011, with a difference of nearly 400 mm between the interannual maximum and minimum; From 2012 to 2020, the fluctuation is small. Although the interannual variation of evaporation fluctuated, it showed an upward trend with a slope of 8.855 mm/year. The annual average temperature showed an obvious upward trend with a slope of 0.040 °C/year. From 1980 to 2020, the inflow of Daihai Lake shows a downward trend; Since 2013, the runoff into the lake has tended to be flat. Climate change and human activities are the decisive factors leading to the change of water quantity in Daihai, among which human activities play a greater role. Cultivated land irrigation and industrial water use are highly correlated with the lake discharge, and these two factors have a great influence on the lake discharge. If the current agricultural and industrial water consumption does not increase, Daihai still has a lifespan of nearly 120 years. If human activities do not change and any protective measures are not taken in time, under the background of global climate change, the flow of the Daihai Lake into the lake will be reduced to zero in 2025, and the Daihai Lake will completely dry up in 2031–2033. The study of climate hydrological coupling of long time series in Daihai Basin can not only make up for the lack of runoff data, but also provide the basis for water resources management, disaster prevention and mitigation.

Lake-level reconstruction of inland enclosed lakes especially for monsoon-sensitive areas is of great significance to reveal regional climate changes. Daihai, a typical enclosed lake at the marginal of the East Asian summer monsoon (EASM) area in north China, is sensitive to climate changes due to its unique regional characteristics. There were a series of lakeshore terraces, highstand lacustrine sediments, and braided river deltas, providing sufficient geomorphologic and stratigraphic evidence for the reconstruction of lake-level fluctuations of Daihai. Reconstructed lake-level variations during the early and mid-Holocene were constructed based on 22 quartz optical stimulated luminescence (OSL) ages from six well-preserved profiles around Daihai Basin. Our results indicated Daihai showed a relatively low level at 10.2 ka, and a gradually increasing lake level following the enhanced monsoon precipitation during the mid-Holocene. Specifically, the high lake level began to develop at 8.1 ka and reached the maximum at 5.2 ka, with ∼40 m higher than present. At this time, the lake area expanded to ∼400 km2, approximately six times as large as that of present, corresponding to the maximum monsoon precipitation and intensity of EASM during the mid-Holocene. However, our stratigraphic records showed a part of the depositional records in the north and east of the Daihai was missed after 5.2 ka, probably indicating a sudden drop of the Daihai lake level. These rapid level fluctuations were likely to be interpreted by some local scenarios and need to be further investigated in the future. Overall, the lake-level fluctuation of Daihai during the early and mid-Holocene was slightly different from that observed in the previously published regional records. Possibly, the interaction of the EASM and regional feedback from topography, and hydrology factors might have contributed to the spatial complexity and distinction.

n-Alkanes are one of the most used proxies in lake sediments to reconstruct past climate change. However, the distribution and concentration of n-alkanes are controlled by multiple factors, and their interpretation across northern China has revealed obvious discrepancies. It is therefore important to investigate the controlling factors of n-alkane proxies before using them for paleoclimate reconstruction. In this study, we collected fresh plant leaves, basin surface soils, lake surface sediments, and a short sediment core (DH20B) in the Daihai Lake basin to analyze the paleoclimate implications of n-alkanes. Our results show that long-chain (C27–C35) n-alkanes in Daihai Lake are dominated by allochthonous sources. The average chain length of long-chain n-alkanes (ACL27–35) and total long-chain n-alkane concentration (∑alklong-chain) of DH20B are significantly correlated with regional summer temperature (r = 0.54, p &amp;lt; 0.01) and summer precipitation (r = 0.41, p &amp;lt; 0.05) over the past 60 years. These results indicate that ACL27–35 and ∑alklong-chain from Daihai Lake sediments have the potential to reconstruct past summer temperature and summer precipitation, respectively, because higher summer temperature promotes the synthesis of longer-chain n-alkanes to reduce water loss (leading to higher ACL27–35) and increased summer precipitation promotes plant growth (leading to higher ∑alklong-chain). Moreover, we found that human activity significantly affected ∑alklong-chain through cultivation and grazing after 2005. Our findings may have broad significance for paleoclimate reconstruction of other hydrologically closed lakes, highlighting the importance of proxy validation studies.

Understanding the water quality and its influencing factors of different water bodies is essential for managing water resources in closed inland lake basins in semi-arid regions. However, generally, groundwater or surface water is assessed separately, and the differences among different water bodies are neglected. This study assessed the water quality and its influencing factors of different water bodies in the Daihai Lake Basin (a closed inland lake basin in a semi-arid region) by analysing the hydrochemical data of groundwater, and spring, river, and lake waters in the dry and wet seasons. The dominant hydrochemical type of groundwater (81.48%), spring water (80%), and river water (83.33%) was HCO3–Ca•Mg, while that of lake water was Cl-Na (100%). Groundwater, spring water, and river water were suitable for drinking and agricultural irrigation; however, the groundwater quality was worse in the wet season than in the dry season. Na+ and Cl– majorly affected the lake water quality. The mean NO3– concentration in groundwater was 28.39 mg/L, and its non-carcinogenic hazard quotient indicated that high risk areas were mainly distributed in Tiancheng and northern Maihutu. The hydrochemical compositions of groundwater, spring water, and river water were mainly influenced by rock (silicate and carbonate) weathering and cation exchange, and agricultural activities were the main sources of groundwater NO3–. Moreover, the lake hydrochemical composition was mainly affected by evaporation and halite dissolution. Thus, groundwater NO3– pollution and lake water salinisation should be prioritised. These findings provide a more thorough understanding of water quality and its influencing factors in the closed inland lake basin in the semi-arid region, and can be used to develop the protection of ecosystems and water resources management strategies in the Daihai Lake Basin.

The quantitative relationship between land use/cover change (LUCC) within basins, lake water environmental factors, and water quality has long been a popular research area. In this study, we investigated three typical basins (Ulansuhai Basin, Daihai Basin, and Dalinor Basin) in arid and semi-arid areas of China. The assessment was based on the China Land Cover Dataset (CLCD), which was used to calculate the land use dynamic degree index and Markov transfer matrix. Moreover, an econometric analysis model and a hybrid evolutionary algorithm (HEA) model were used to explore the quantitative relationship between LUCC and environmental factors on the lake water quality. The results showed that the LUCC of the three lake basins was dominated by cultivated land and grassland over the past 20 years. In all of the basins, grassland and water area were converted into cultivated land, water area decreased to varying degrees, and impervious surface area increased continuously. Moreover, the concentration of TN and TP were generally proportional to chemical oxygen demand concentration (COD), biochemical oxygen demand concentration (BOD5), and dissolved oxygen concentration (DO), but inversely proportional to water depth and transparency; the relationship between Nutrient concentration and pH was usually related to the ecological threshold. On the basin scale, the grassland and forestland played positive roles in improving water quality, while cultivated land and impervious surface were the main factors contributing to water pollution. Overall, this study provides a scientific theoretical basis for the rational utilization of land resources, improvement of lake water quality, and ecological protection of typical lake basins in arid and semi-arid regions.

ABSTRACTThe rapidly accumulating alluvial fans are important archives of tectonic and climatic processes. However, deciphering how alluvial fans respond to orbital‐scale climate fluctuations remains unclear. While some alluvial fans exhibit a distinct response to glacial‐interglacial cycles, others do not. This detailed outcrop study of the late Quaternary Bantanzi alluvial fan in the Daihai Lake Basin, northern China, reveals two stratigraphic intervals with distinct facies, where a lower stratigraphic succession is dominated by debris flow deposits and palaeosols and a higher stratigraphic unit by flash‐flood deposits and loess. Physical correlations to well‐dated successions on the Chinese Loess Plateau provide a chronological framework. The palaeosols and the elevated values in magnetic susceptibility of the debris flow‐dominated interval, dated 88.1 to 73.4 ka (the last interglacial period MIS5, 130 to 70 ka), indicate a climate with intense seasonal monsoon rainfall, which facilitated chemical weathering and saturation of clay‐rich sediments on hillslopes triggering debris flows. The wind‐blown loess deposits together with regional data in the flash flood‐dominated interval, dated 58.5 to 22.1 ka (the last glacial period MIS 2 to 4, 70 to 14 ka), indicate an arid climate with highly intermittent and short‐duration rainfall. Such rainfall conditions tend to promote rapid run‐off and generate flash floods, as well as hinder hillslope saturation and chemical weathering resulting in a regolith with higher permeability and erodibility, hindering high pore pressures from building up and promoting erosion by run‐off. These distinct climatic conditions between interglacial and glacial periods were controlled by the latitudinal shift of the margin of the East Asian Monsoon. The Bantanzi fan's position at this climatic boundary, coupled with its small size, made it highly sensitive to glacial‐interglacial cycles. Comparison with other fan systems suggests that the position of alluvial fans at distinct climate boundaries, rather than within the climate zones, is an important control on their sensitivity to climate changes and their potential as climate‐change archives.

Abstract Background The Swan Goose (Anser cygnoides) breeds across Mongolia and adjacent China and Russia and winters exclusively in China. It is globally threatened, showing long-term major range contractions and declining abundance, linked to habitat loss and degradation. We remain ignorant about the biogeographical subpopulation structure of the species and potential differences in their migration timing, stopovers and schedules, information that could be vital to effective conservation of different elements of the species population, which we address here with results from a telemetry study. Methods In 2017–2018, we attached GPS/GSM telemetry devices to 238 Swan Geese on moulting sites in three discrete parts of their summering area (Dauria International Protected Area, Central Mongolia and Western Mongolia), generating 104 complete spring and autumn migration episodes to compare migration speed and nature between birds of different summer provenances. Results Birds from all three breeding areas used almost completely separate migration routes to winter sympatrically in the Yangtze River floodplain. Although many features of the spring and autumn migrations of the three groups were similar, despite the significantly longer migration routes taken by Western Mongolian tagged birds, birds from Dauria Region arrived significantly later in winter due to prolonged staging in coastal areas and took longer to reach their breeding areas in spring. Among birds of all breeding provenances, spring migration was approximately twice as fast as autumn migration. Areas used by staging Swan Geese (mainly wetlands) in autumn and spring almost never fell within national level protected areas, suggesting major site safeguard is necessary to protect these critical areas. Conclusions This study showed the discreteness of migration routes taken by birds of different summer provenances and differences in their migratory patterns, highlighting key staging areas (Yalu River Estuary in China/North Korea for Dauria Region breeding birds, Daihai Lake for Central Mongolian and Ordos Basin for Western Mongolian birds). Based on this new knowledge of the biogeographical subpopulation structure of the Swan Goose, we need to combine data on subpopulation size, their distribution throughout the annual life cycle and conservation status, to develop more effective conservation strategies and measures to reverse population decline throughout the range.

AbstractDuring freezing periods, nutrients (carbon and organic matter, etc.) are enriched in the water and sediment of lakes in cold-arid regions, leading to potential algal bloom outbreaks and other health risks to the ecosystem. Particularly, dissolved organic matter (DOM) is a critical component of the nutrients and plays an important role in the global carbon cycle. However, the mechanisms of DOM transfer between ice and water remain unclear. This study analyzed the influence of microbial community on DOM composition using 16 s RNA, 3DEEM, and FT-ICR MS in Daihai Lake and Wuliangsuhai Lake in the Yellow River Basin, China. According to the spectral analysis, the content of endogenous organic matter, such as humus, accounted for 40% of the total DOM in water, while the content of tryptophan and tyrosine accounted for 80% of the total DOM in ice. The results of mass spectrometry showed that lignin was the main component, and the content of organic matter in the ice was less than that in the water. Molecular structures of seven DOM coexisting in the lake ice and water were elucidated with adapted Kendrick-analogous network visualization, which clearly illustrates that long-chain DOM molecules are derived from small molecules, while other heteroatoms are complexed with the side groups. The positive correlations between CHO, CHNO, CHOS, CHOS and Actinomyces indicate that DOM actively interacted with the microbial community. 44% of CHO compounds have the same molecular formula in water, the content of CHOS in the water of the two lakes was closed to 7% higher than that in the ice. Meanwhile, DOM dynamically migrate between ice and water via interstitial water because of the solubility changes under microbial transformation, which has been proved by the decrease in the contents of the humus and tryptophan-like substances in the ice from the bottom to the surface and lower contents of carbohydrate and unsaturated aromatic hydrocarbon in the water than the ice. This study helps to predict the composition and structure of DOM during the migration in lakes and provides a scientific basis for environmental remediation with high concentration of carbon.