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Journal articles on the topic 'Damage spleen'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Chen, Haoxiang, Feiyao Wang, Xingyue Wu та ін. "Chronic Heat Stress Induces Oxidative Stress and Induces Inflammatory Injury in Broiler Spleen via TLRs/MyD88/NF-κB Signaling Pathway in Broilers". Veterinary Sciences 11, № 7 (2024): 293. http://dx.doi.org/10.3390/vetsci11070293.

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The spleen is the largest peripheral immune organ of the organism, accounting for 25% of the total lymphoid tissue of the body. During HS, the spleen is damaged due to the elevated environment, which seriously affects life performance and broilers’ health. This study aimed to investigate the mechanism of chronic HS damage to broiler spleen tissues. The broilers were typically raised until they reached 21 days of age, after which they were arbitrarily allocated into two groups: an HS group and a cntrol group. The HS group was subjected to a temperature of 35 °C for 10 h each day, starting at 21

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Ulaş, Mustafa. "Valproic Acid Attenuates Oxidative Damage in Rat Spleen Tissue Induced By Spinal Cord Damage." Turkish Journal of Agriculture - Food Science and Technology 10, sp2 (2022): 3054–56. http://dx.doi.org/10.24925/turjaf.v10isp2.3054-3056.5802.

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Events such as oxidative stress caused by spinal cord injury (SCI) are a serious condition because they negatively affect many organs. Alternative treatment options for this type of injury are quite limited. In this study, we planned to investigate the effect of oxidative damage on the spleen tissue of rats with spinal cord damage and the protective role of valproic acid (VPA) in this damage. Sixteen Wistar albino rats were divided into two equal groups. No treatment was administered to the rats in Group 1 (SCI-(Control), but a single dose of 300 mg/kg intraperitoneally VPA was administered to

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Kit, Oleg, Yevgeniy Kolesnikov, Mikhail Kozhushko, and Aleksandr Snezhko. "A RARE CASE OF METASTASIS OF GASTRIC CANCER IN THE SPLEEN." Problems in oncology 63, no. 1 (2017): 153–54. http://dx.doi.org/10.37469/0507-3758-2017-63-1-153-154.

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The spleen’s damage by metastases of malignant tumors is occasional. There is presented a clinical observation of rare isolated metastasis of gastric cancer in the spleen without concomitant dissemination that is interesting.

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Ding, Rui, Han Huang, Hongyu Wang, et al. "Goose Nephritic Astrovirus Infection of Goslings Induces Lymphocyte Apoptosis, Reticular Fiber Destruction, and CD8 T-Cell Depletion in Spleen Tissue." Viruses 13, no. 6 (2021): 1108. http://dx.doi.org/10.3390/v13061108.

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The emergence of a novel goose nephritic astrovirus (GNAstV) has caused economic losses to the Chinese goose industry. High viral load is found in the spleen of goslings infected with GNAstV, but pathological injuries to the spleen due to GNAstV are largely unknown. In this study, 50 two-day-old goslings were infected orally with GNAstV, and 50 goslings were treated with PBS as control. Spleens were collected at different times following infection to assess damage. GNAstV infection caused visceral gout and urate deposition in joints, and resulted in 16% mortality. GNAstV was found in the lymph

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Li, Xiaocong, Xin Zeng, Wanqin Yang, Peng Ren, Hengxiao Zhai, and Heng Yin. "Impacts of Copper Deficiency on Oxidative Stress and Immune Function in Mouse Spleen." Nutrients 17, no. 1 (2024): 117. https://doi.org/10.3390/nu17010117.

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Introduction: Copper is an essential trace element crucial for enzyme synthesis and metabolism. Adequate copper levels are beneficial for maintaining the normal immune function of the spleen. Copper deficiency disrupts the metabolic processes within the spleen and impairs its immune function. This research examines the impact of copper deficiency on the spleen and the potential recovery following copper supplementation. Methods: Weaned mice underwent a 4-week copper-deficient diet, succeeded by 1-week of copper repletion via intraperitoneal copper sulfate injection. Histological examination wa

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Ali, Asma Basharat, Nadia Younus, Sahrish Mukhtar, Lubna Faisal, Tayyaba Kazmi, and Alina Atif. "Evaluating Vitamin E's Antioxidative Effect on Carbamazepine-Induced Spleen Damage in Rat Models." Pakistan Journal of Medicine and Dentistry 13, no. 3 (2024): 132–39. https://doi.org/10.36283/pjmd13-3/018.

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Background: The spleen is essential for the body’s homeostasis and immune system. Carbamazepine (CBZ) is known to cause toxicity to several organs, including the spleen, through oxidative stress, however, vitamin E (Vit E) is a proven antioxidant against toxins. Thus, this study evaluated the antioxidative effect of Vit E on hematological and splenic toxic changes, caused by carbamazepine in rats. Methods: This in-vivo preclinical experimental study was conducted from March-June 2020, at Jinnah Medical and Dental College, Karachi. Forty adult male rats, weighing 150-200 grams were included and

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Hildebrand, P., U. J. Roblick, E. Schlöricke, R. Czymek, H. P. Bruch, and C. Bürk. "The role of organ preservation in the surgical therapy of traumatic spleen injury." Acta chirurgica Iugoslavica 58, no. 4 (2011): 21–25. http://dx.doi.org/10.2298/aci1104021h.

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Background: New findings on immunological und haematological functions of the spleen, the postoperative risks following splenectomy, as well as improved surgical techniques resulted in an increased interest in organ preservative surgery after traumatic spleen injury in recent years. Material and Methods: The data of all patients who un-derwent surgery for traumatic spleen injuries between 1995 - 2009 were recorded prospectively and analyzed concerning type of operation, intra-and postoperative complications and the postoperative course. Results: A total of 214 patients with splenic trauma unde

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Zhang, T., Q. Zhao, Y. Zhang, and J. Ning. "Assessment of genotoxic effects of flumorph by the comet assay in mice organs." Human & Experimental Toxicology 33, no. 3 (2013): 224–29. http://dx.doi.org/10.1177/0960327111417268.

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The present study investigated the genotoxic effects of flumorph in various organs (brain, liver, spleen, kidney and sperm) of mice. The DNA damage, measured as comet tail length (µm), was determined using the alkaline comet assay. The comet assay is a sensitive assay for the detection of genotoxicity caused by flumorph using mice as a model. Statistically significant increases in comet assay for both dose-dependent and duration-dependent DNA damage were observed in all the organs assessed. The organs exhibited the maximum DNA damage in 96 h at 54 mg/kg body weight. Brain showed maximum DNA da

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9

Sefc, Ludek, Ko-Tung Chang, Viktor Sykora, and Emanuel Necas. "Mobilization with Cyclophosphamide Shifts Hematopoiesis From the Bone Marrow to the Spleen In Mouse." Blood 116, no. 21 (2010): 1590. http://dx.doi.org/10.1182/blood.v116.21.1590.1590.

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Abstract Abstract 1590 Introduction: Spleen is an active hematopoietic tissue in adult mice. Spleen niches supporting hematopoiesis were not extensively studied yet. Spleen does not contain osteoblastic niches which are considered to be essential for long-term hematopoiesis, and splenic hematopoiesis is assumed to originate mainly from progenitors with short-term repopulating ability. Normal spleen is primarily a lymphoid organ but it also contributes to myelopoiesis by containing approximately 5% of total body multipotent progenitors CFU-S. We have studied the effect of mobilization with cycl

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Baraaj, Abed Hassan, and Harith Jabbar Fahad Al-Mathkhury. "Histopathological changes in Spleen caused by Pseudomonas aeruginosa DNA." Greener Journal of Biological Sciences 3, no. 8 (2013): 319–24. https://doi.org/10.15580/gjbs.2013.8.060913819.

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Upon its release due to cell lysis, bacterial DNA has the ability to stimulate the immune system causing serious damage in tissue. Intraperitoneally injection of <em>P. aeruginosa</em> DNA in rats caused several histopathological changes in the splenic tissue included; a marked germinal center hyperplasia in the white pulp which results in the increase of follicles number within germinal center. Furthermore, apoptotic debris engulfed by macrophages in the marginal zone was noticed. Hemosiderin and degenerated cells were observed as well. In a conclusion, even though the bacterial cel

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11

Ma, Dandan, Minhong Zhang, and Jinghai Feng. "Dietary Peppermint Extract Inhibits Chronic Heat Stress-Induced Activation of Innate Immunity and Inflammatory Response in the Spleen of Broiler Chickens." Animals 14, no. 8 (2024): 1157. http://dx.doi.org/10.3390/ani14081157.

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The aim of this study was to investigate the effect of dietary peppermint extract (PE) on innate immunity and inflammatory responses in the spleen of broiler chickens under chronic heat stress. In order to further study the mechanism of the activation of innate immunity and inflammation induced by chronic heat stress and the regulatory effect of peppermint extract, we examined the spleen’s histological change, the mRNA expression of major pattern recognition receptors (PRRs) (TLR2, TLR4, NOD1, MDA5 and DAI) and transcription factors (NF-κB, AP-1 and IRF3) and downstream inflammatory cytokines

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McDaniel Mims, Brianyell, Josue Enriquez, Andrea Pires dos Santos, et al. "Antibiotic administration exacerbates acute graft vs. host disease-induced bone marrow and spleen damage in lymphopenic mice." PLOS ONE 16, no. 8 (2021): e0254845. http://dx.doi.org/10.1371/journal.pone.0254845.

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Background Hematopoietic stem cell transplantation is a potential cure for certain life-threatening malignant and nonmalignant diseases. However, experimental and clinical studies have demonstrated that pre-transplant myeloablative conditioning damages the gut leading to translocation of intestinal bacteria and the development of acute graft vs. host disease (aGVHD). The overall objective of this study was to determine whether administration of broad spectrum antibiotics (Abx) affects the onset and/or severity of aGVHD in lymphopenic mice that were not subjected to toxic, pre-transplant condit

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Türkoğlu, Ahmet. "A planned delayed laparoscopy in a gunshot injury case with spleen and diaphragmatic damage." Dicle Medical Journal 41, no. 4 (2014): 758–59. http://dx.doi.org/10.5798/diclemedj.0921.2014.04.0515.

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Qin, Shixin, Haichao Wang, Renqi Yuan, et al. "Role of HMGB1 in apoptosis-mediated sepsis lethality." Journal of Experimental Medicine 203, no. 7 (2006): 1637–42. http://dx.doi.org/10.1084/jem.20052203.

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Severe sepsis, a lethal syndrome after infection or injury, is the third leading cause of mortality in the United States. The pathogenesis of severe sepsis is characterized by organ damage and accumulation of apoptotic lymphocytes in the spleen, thymus, and other organs. To examine the potential causal relationships of apoptosis to organ damage, we administered Z-VAD-FMK, a broad-spectrum caspase inhibitor, to mice with sepsis. We found that Z-VAD-FMK–treated septic mice had decreased levels of high mobility group box 1 (HMGB1), a critical cytokine mediator of organ damage in severe sepsis, an

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15

Fomina, K. V., T. V. Khramova, A. S. Terentiev, and O. S. Terentievа. "Histological analysis of the spleen of rats immunized with SARS-CoV-2 S protein." Russian Journal of Immunology 27, no. 3 (2024): 463–70. http://dx.doi.org/10.46235/1028-7221-16599-hao.

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SARS-CoV-2 infection can lead to pathological disorders in various organs due to the ubiquitous of angiotensin-converting enzyme 2 (ACE2), which serves as a receptor for SARS-CoV-2. However, tissue damage may not only be the result of viral infection. SARS-CoV-2 has been shown to induce the production of autoantibodies to ACE2, and their presence is associated with disease severity. The spleen is one of the targets for COVID-19. The presence of ACE2 in the red pulp sinus endothelium cells of the spleen and in tissue-resident CD169+ macrophages positioned in the splenic marginal zone makes thes

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Khvan, O. I., A. N. Don, Kh Kh Yakubov, and T. K. Nasyrov. "PECULIARITIES OF FORENSIC MEDICAL ASSESSMENT OF LIVER, SPLEEN AND KIDNEY DAMAGE DURING A FALL FROM HEIGHT." International Journal of Medical Sciences And Clinical Research 03, no. 02 (2023): 26–31. http://dx.doi.org/10.37547/ijmscr/volume03issue02-06.

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The article reflects the data of an expert assessment of blunt abdominal trauma in a fall from a height. It is especially important to find out the circumstances of the injury in order to have an idea of possible damage to the hollow and parenchymal organs of the abdominal cavity. According to the conducted studies, when falling from a height, characteristic damage was established, depending on the height of the fall.

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17

Enriquez, Josue, Brianyell McDaniel Mims, Stephanie Stroever, et al. "Influence of Housing Temperature and Genetic Diversity on Allogeneic T Cell-Induced Tissue Damage in Mice." Pathophysiology 30, no. 4 (2023): 522–47. http://dx.doi.org/10.3390/pathophysiology30040039.

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The objective of this study was to determine how housing temperature and genetic diversity affect the onset and severity of allogeneic T cell-induced tissue damage in mice subjected to reduced intensity conditioning (RIC). We found that adoptive transfer of allogeneic CD4+ T cells from inbred donors into sub-lethally irradiated inbred recipients (I→I) housed at standard housing temperatures (ST; 22–24 °C) induced extensive BM and spleen damage in the absence of injury to any other tissue. Although engraftment of T cells in RIC-treated mice housed at their thermo-neutral temperature (TNT; 30–32

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18

He, Ruyi, Shijie Zhang, Jiale Yu, et al. "Per1/Per2 Knockout Affects Spleen Immune Function in Elderly Mice via Inducing Spleen Lymphocyte Ferroptosis." International Journal of Molecular Sciences 23, no. 21 (2022): 12962. http://dx.doi.org/10.3390/ijms232112962.

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Disturbances in circadian rhythms are known to affect immune functions. However, the long-term impact of abnormal circadian rhythms on the immune-related functions of the spleen are poorly understood. Hence, we aimed to investigate the immune-related functions of spleen in Per1/Per2 double-knockout (DKO) and wild-type (WT) mice aged 4, 9, and 14 months. Compared to the WT mice, the DKO mice had smaller spleen white pulp (WP) and lymphocyte germinal area, as well as fewer immune cells with age—these differences were especially clear. The spleen lymphocyte mortality, malondialdehyde (MDA) levels

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Sundukov, Sundukov A. V., Puchkov S. S. Puchkov, Faller A. P. Faller, and Svechnikova E. V. Svechnikova. "Spleen damage in HIV infection, diagnostic and treatment issues." Pharmateca 9_2024 (December 27, 2024): 167–72. https://doi.org/10.18565/pharmateca.2024.9.167-172.

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20

Zhang, Qirui, Hong-xin Zhang, Yu Chen, Ying Wang, Mei Yang, and Mengyao Guo. "Zinc Deficiency Induces Oxidative Damage and Causes Spleen Fibrosis." Biological Trace Element Research 194, no. 1 (2019): 203–9. http://dx.doi.org/10.1007/s12011-019-01762-y.

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21

Babkina, O. P., and S. I. Danylchenko. "Ultrasound Diagnostics of the Nature and Duration of Abdominal Trauma." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, no. 2 (2021): 169–80. http://dx.doi.org/10.26693/jmbs06.02.169.

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The purpose of the study was to study a complex of changes in ultrasound parameters of injured tissues of the liver, spleen, pancreas in mechanical trauma and their dependence on the nature and duration of injury. Materials and methods. Ultrasound examinations were performed in 60 injured patients (41 males and 19 females) aged 20 to 60 years old in the dynamics as for the 1st, 2nd, 3rd, 4th and 5th days after injury. Puncture, transverse and oblique scans from all possible accesses were used. The conditions of the liver, pancreas, spleen, kidneys were studied. Results and discussion. In the c

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Podkamenev, V. V., I. A. Pikalo, T. M. Andaeva, and T. N. Boiko. "STRUCTURE FUNCTIONAL STATE OF DAMAGED SPLEEN IN CHILDREN AFTER NONOPERATIVE TREATMENT." Grekov's Bulletin of Surgery 175, no. 1 (2016): 64–70. http://dx.doi.org/10.24884/0042-4625-2016-175-1-64-70.

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The results of treatment of 75 children with spleen damage were studied. The conservative treatment was applied in 69 (92%) cases. A restoration of spleen structure was noted in case of spleen injury on 3-4 weeks. The complete normalization of the spleen structure occurred in terms of 3-4 months after trauma. Posttraumatic cysts appeared in case of large defects and hematomas after 2-3 weeks and disappeared by 5-6 months. The regenerative process of shallow ruptures was registered after 3-10 weeks, but the deep ruptures were healed after 6-30 weeks. The preservation of the spleen after trauma

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Gao, Rong, Zhenhui Wu, Wanyun Dang, et al. "Th1/Th2 Immune Imbalance in the Spleen of Mice Induced by Hypobaric Hypoxia Stimulation and Therapeutic Intervention of Astragaloside IV." International Journal of Molecular Sciences 26, no. 6 (2025): 2584. https://doi.org/10.3390/ijms26062584.

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This study aims to establish a hypobaric hypoxia-induced immune injury model and investigate the intervention and therapeutic effects of Astragaloside IV (AS-IV). This study simulated hypobaric hypoxia stimulation in mice at an altitude of 7000 m on a plateau for 1, 3, 5, and 7 days. HE staining and transcriptomic analysis were performed on mouse spleens. In addition, AS-IV was selected for intervention in prevention and treatment, and validated by flow cytometry, ELISA, and Q-PCR. The results showed that under simulated hypoxic conditions at an altitude of 7000 m for 5 days, the peripheral bl

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Demircioğlu, Muhammed, and Muhammet Bahaeddin Dörtbudak. "Protective effect of Gundelia tournefortii extract on spleen tissue in experimental type I diabetes in rats." Journal of Medical and Dental Investigations 4 (December 29, 2023): e230339. http://dx.doi.org/10.5577/jomdi.e230339.

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Aim: In this study, it was aimed to investigate the effects of Gundelia tournefortii plant extract on the spleen of rats with experimental type of rats. Methods: In the study, 35 adult Wistar Albino rats were used. Thirty-five male rats were randomly divided into five equal groups of seven rats each. Animal groups were determined as Control, Diabetes, Diabetes + Treatment 1, Diabetes + Treatment 2, Diabetes + Treatment 3. The control group was not exposed to any treatment. The other groups received 45 mg/kg Streptozotocin intraperitoneally on the experimental day. Animals in Diabetes + Treatme

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Nurhayati, Nurhayati, Shahibul Auzan, Lia Handayani, Azwar Thaib, T. M. Haja Almuqaramah, and Faisal Syahputra. "The effectiveness of activated charcoal in feed on histopathological features of the spleen of tilapia (Oreochromis niloticus) exposed to organophosphate insecticides." Acta Aquatica: Aquatic Sciences Journal 10, no. 1 (2023): 72. http://dx.doi.org/10.29103/aa.v10i1.10832.

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Excessive and periodic use of insecticides has a negative impact on aquatic areas and the biota in them. Pesticides that accumulate in the aquatic environment affect the life non target organisms such as fish. In addition, pesticides can cause damage to the gills, liver, intestines and spleen. This organ plays an important role in the immune system. Thus, an alternative is needed to overcome this problem, one of which is the addition of activated charcoal in the feed. The aims of study to determine the effect of the use of activated charcoal in feed on the histopathological description of the

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Nurhayati, Nurhayati, Shahibul Auzan, Lia Handayani, Azwar Thaib, T. M. Haja Almuqaramah, and Faisal Syahputra. "The effectiveness of activated charcoal in feed on histopathological features of the spleen of tilapia (Oreochromis niloticus) exposed to organophosphate insecticides." Acta Aquatica: Aquatic Sciences Journal 10, no. 2 (2023): 72. http://dx.doi.org/10.29103/aa.v1i2.9223.

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Excessive and periodic use of insecticides has a negative impact on aquatic areas and the biota in them. Pesticides that accumulate in the aquatic environment affect the life non target organisms such as fish. In addition, pesticides can cause damage to the gills, liver, intestines and spleen. This organ plays an important role in the immune system. Thus, an alternative is needed to overcome this problem, one of which is the addition of activated charcoal in the feed. The aims of study to determine the effect of the use of activated charcoal in feed on the histopathological description of the

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27

Gu, Jie, Yanwei Wang, Yanmin Liu, et al. "Inhibition of Autophagy Alleviates Cadmium-Induced Mouse Spleen and Human B Cells Apoptosis." Toxicological Sciences 170, no. 1 (2019): 109–22. http://dx.doi.org/10.1093/toxsci/kfz089.

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Abstract Cadmium (Cd) is a toxic heavy metal that can accumulate and cause severe damage to many organs, such as liver, kidney, lung, etc. Cd also significantly suppresses immunity, however, the underlying mechanism involved in Cd-induced immunnotoxicity is still unclear. The present study indicated that semichronic Cd exposure (7 days) induced apoptotic damage of mouse spleen. In human Ramos B cells, Cd exposure also induced apoptosis, which was dependent on Cd-induced vacuole membrane protein 1 (VMP1) expression and autophagy. Cd-induced autophagy and apoptosis were abated when VMP1 expressi

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Zhang, Yu, Yanan Yu, Yue Gao, et al. "Studies on the Protective Effect of Silybin Against Low-Dose Radiation-Induced Damage to the Immune System." International Journal of Molecular Sciences 26, no. 12 (2025): 5656. https://doi.org/10.3390/ijms26125656.

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With growing public concern about the health effects of low-dose radiation, numerous studies have demonstrated that low-dose radiation can cause damage to the immune system, making intervention measures essential. This study investigated the protective effects of silybin against low-dose radiation-induced immune system damage and its underlying mechanisms at both the cellular and animal levels. At the cellular level, CCK-8 assays, ROS measurements, and RT-qPCR analysis revealed that silybin alleviated the reduction in RAW264.7 cell proliferation, intracellular ROS levels, and inflammatory cyto

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Akmal Abdullaevich Saidov. "Morphological Changes of the Spleen with Polypragmasia." Procedia of Social Sciences and Humanities 4 (April 26, 2022): 23–24. http://dx.doi.org/10.21070/pssh.v4i.99.

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The study was conducted on 100 white random-bred rats of newborns, three and six months old. Animals were taken out of the experiment at 3 months of age by instantaneous decapitation of animals under ether anesthesia. After opening the abdominal cavity, macroscopic changes in the spleen were studied. Using a caliper, the anatomical parameters of the extracted spleen were measured. The spleen was fixed in Carnoy's solution for further study. Treatment with no steroidal drugs showed damage to the lymphoid tissue of the spleen, structural changes in the pulp and a decrease in the mass of the sple

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Umedov, Khushvaqt Alisherovich, Hamza Rashidovich Shomurodov, and Yokubjon Erkin ugli Khursanov. "OUR EXPERIENCE IN CONSERVATIVE TREATMENT OF SPLEEN INJURY IN CLOSED ABDOMINAL TRAUMA." Research Focus 2, no. 1 (2023): 319–25. https://doi.org/10.5281/zenodo.7592964.

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The spleen has a number of important functions, the main of which are participation in hematopoiesis, the body's immune status, and an important role in the hemostasis system [2, 5]. In particular, after splenectomy, there is a change in the main indicators of the vascular-platelet hemostasis link: an increase in the number of platelets and their functional activity, including adhesive ability, the reaction of the release of platelet factors is disturbed, and the retraction index decreases [7]. Changes can also be traced in the coagulation link of the hemostasis system: there is a shorteni

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Nemmar, Abderrahim, Priya Yuvaraju, Sumaya Beegam, Mohamed A. Fahim, and Badreldin H. Ali. "Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/9639035.

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CeO2 nanoparticles (CeO2 NPs) which are used as a diesel fuel additive are emitted in the particulate phase in the exhaust, posing a health concern. However, limited information exists regarding the in vivo acute toxicity of CeO2 NPs on multiple organs. Presently, we investigated the acute (24 h) effects of intratracheally instilled CeO2 NPs in mice (0.5 mg/kg) on oxidative stress, inflammation, and DNA damage in major organs including lung, heart, liver, kidneys, spleen, and brain. Lipid peroxidation measured by malondialdehyde production was increased in the lungs only, and reactive oxygen s

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Semichev, Ye V., A. N. Baikov, P. S. Bushlanov, and G. Ts Dambayev. "COMPARATIVE ANALISYS OF HEMOSTASIS METHODS IN OPERATIONS ON SPLEEN." Bulletin of Siberian Medicine 14, no. 2 (2015): 91–99. http://dx.doi.org/10.20538/1682-0363-2015-2-91-99.

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The paper provides statistics of spleen traumas, anatomy and characters of the organ damage. The most common methods of spleen hemostasis, currently used in surgical clinics of the Russian Federation, are presented. A small historical excursus about existed methods of hemostasis is given in the paper. A comparative analysis of currently used methods, their advantages and disadvantages is carried out. Some possible criteria for an ideal method of spleen hemostasis are listed as well.

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Meiyasa, Firat, Betty Sri Laksmi Jenie, Lilis Nuraida, and Nurbety Tarigan. "THE ABILITY OF Lactobacillus plantarum BSL IN REDUCING THE TISSUE DAMAGE OF LIVER AND SPLEEN IN RATS INFECTED BY Listeria monocytogenes ATCC 7644." AGRISAINTIFIKA: Jurnal Ilmu-Ilmu Pertanian 3, no. 2 (2020): 88. http://dx.doi.org/10.32585/ags.v3i2.542.

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Lactobacillus plantarum BSL, previously isolated from Indonesian sauerkraut. In this study, we investigated the ability of L. plantarum BSL in reducing the tissue damage of liver and spleen in rats infected by Listeria monocytogenes ATCC 7644. Treatment group of rats received 0.5 mL culture suspension (109 CFU/mL) of L. plantarum BSL and control group received 0.5 mL of 0.85% w/v NaCl daily for nine days of experiment. Both groups were infected at 3rd day with 0.5 mL of suspension of L. monocytogenes (109CFU/mL). At the 2nd (before infection), 5th, 7th, and 9th day (after infection), the rats

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Freitas, José Claudio Carneiro de, Adam Leal Lima, and Diana Célia Sousa Nunes-Pinheiro. "Spleen damage in a dog naturally infected by Leishmania infantum." Revista da Sociedade Brasileira de Medicina Tropical 50, no. 2 (2017): 280–81. http://dx.doi.org/10.1590/0037-8682-0094-2016.

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Pamuk, Omer Nuri, Peter H. Lapchak, Poonam Rani, Polly Pine, Jurandir J. Dalle Lucca, and George C. Tsokos. "Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion." American Journal of Physiology-Gastrointestinal and Liver Physiology 299, no. 2 (2010): G391—G399. http://dx.doi.org/10.1152/ajpgi.00198.2010.

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Reperfusion injury to tissue following an ischemic event occurs as a consequence of an acute inflammatory response that can cause significant morbidity and mortality. Components of both the innate (complement, immunoglobulin, monocytes, and neutrophils) and adaptive (B and T lymphocytes) immune systems have been demonstrated to mediate tissue injury. Spleen tyrosine kinase (Syk) is responsible for membrane-mediated signaling in various cell types including B lymphocytes, macrophages, and T cells. We investigated the ability of a small drug Syk inhibitor, R788, to protect mice against mesenteri

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Short, Christie, Helen O'Neill, and Jonathan Tan. "3180 – INVESTIGATING IRRADIATION DAMAGE TO HAEMATOPOIETIC NICHES IN THE SPLEEN." Experimental Hematology 76 (August 2019): e5. http://dx.doi.org/10.1016/j.exphem.2019.09.018.

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Khanenko, O. B., and Yu I. Popovych. "Morphological alterations in the spleen of rats during late stages of experimental streptozotocin-induced diabetes mellitus." Morphologia 18, no. 4 (2025): 95–100. https://doi.org/10.26641/1997-9665.2024.4.95-100.

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Background. Diabetes is a systemic disease that affects various organs and systems of the body. One of the known complications is damage to the immune system. However, changes in the spleen, as the central organ of the immune system in diabetes, have not been studied sufficiently. Objective. To study the features of morphological changes in the spleen in the late stages of experimental diabetes mellitus. Methods. The article presents the results of an experimental study of changes in the spleen parenchyma of rats with streptozotocin diabetes. The study was conducted on 11 adult white male rats

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Tighe, D., R. Moss, S. Boghossian, M. F. Heath, B. Chessum, and E. D. Bennett. "Multi-organ damage resulting from experimental faecal peritonitis." Clinical Science 76, no. 3 (1989): 269–76. http://dx.doi.org/10.1042/cs0760269.

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1. Using specific-pathogen-free New Zealand White rabbits, we have compared the effects of faecal peritonitis over a period of 5 h in eight test animals with eight controls in which a sham operation was performed. 2. There was morphological damage to lungs, liver and spleen of test animals. Lung capillaries and sinusoids of the liver showed occlusion by cell debris and leucocytes, with endothelial damage. The lungs also showed alveolar epithelial disruption, basement membrane exposure and type II pneumocytes lacking lamellar bodies. In the liver there was fibrin deposition and swollen Kupffer

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Lviv, G. S. "Clinic of traumatic injuries of the spleen and immediate results of their surgical treatment." Kazan medical journal 43, no. 4 (2021): 27–29. http://dx.doi.org/10.17816/kazmj87005.

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The frequency of damage to the spleen with closed abdominal injuries is quite high (L.P. Aleksandrovich - 50%, B.E. Imnaishvili - 25%). Despite this, as well as the very dangerous, sometimes fatal bleeding that accompanies rupture of the spleen, diagnostic errors are not uncommon. Of particular difficulty is the diagnosis of rupture of the spleen, when there is a light interval between the injury, often minor, and the onset of severe internal bleeding. Sometimes the light interval is several days, sometimes months (Yu. Ya. Kulik).

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Olukayode, Seun B., and Silvanus O. Innih. "Protective Effects of Irvingia gabonensis on Arsenic Trioxide-Induced Spleen Damage in Rats: A Histological and Haematological Study." Dutse Journal of Pure and Applied Sciences 11, no. 1a (2025): 105–13. https://doi.org/10.4314/dujopas.v11i1a.10.

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Considerable attention from basic to clinical scientists has been given to the toxicity of drugs and other related agents, because of the passionate sourcing for the readily available and cheap agents against organotoxicity. We evaluated the protective effects of ethanol leaf extract of Irvingia gabonensis on arsenic trioxide-induced spleen damage in Wistar rats. In this study, rats received the plant extract at doses of 250 and 500 mg/kg body weight. Splenic damage was induced by administering 10 mg/kg body weight of arsenic trioxide for 28 days. The results revealed that arsenic trioxide sig

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Gerasymchuk, P. O., D. V. Osadchuk, D. B. Fira, and A. V. Pavlyshyn. "Video laparoscopy for closed abdominal trauma with liver and spleen damage." Paediatric Surgery. Ukraine, no. 2(79) (June 27, 2023): 44–49. http://dx.doi.org/10.15574/ps.2023.79.44.

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Open and closed abdominal trauma is the structure of traumatic injuries makes up from 1.5% to 36.5% of all injuries, accompanied in 26.7-40.8% of cases by liver and spleen damage. Damage to parenchymal organs of the abdominal cavity most often leads to the development of intra-abdominal bleeding, which is the basis of unsatisfactory results of treatment and death of patients. Among the diagnostic methods, video laparoscopy is becoming more and more important in finding the extent of damage to the internal organs of the abdominal cavity. In emergency cases as a minimally invasive but sufficient

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Żywicka, Bogusława, Zbigniew Rybak, Maciej Janeczek, et al. "Comparison of A 1940 nm Thulium-Doped Fiber Laser and A 1470 nm Diode Laser for Cutting Efficacy and Hemostasis in A Pig Model of Spleen Surgery." Materials 13, no. 5 (2020): 1167. http://dx.doi.org/10.3390/ma13051167.

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Partial and total splenectomies are associated with a high risk of substantial blood loss. Lasers operating at wavelengths strongly absorbed by water have the potential to improve hemostasis and cut while providing a narrow zone of thermal damage. The aim of this study is to compare a thulium-doped fiber laser (TDFL) emitting a wavelength of 1940 nm and a diode laser (DL) operating at 1470 nm for spleen surgery in a pig model. A partial splenectomy and spleen incisions were made in 12 animals using the two laser devices. The hemostasis was evaluated visually during surgeries. Post-mortem and h

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Fan, Lin, and Liwen Wang. "Clinical Experience of Professor Ma Shuanquan in Treating Androgenetic Alopecia." Journal of Contemporary Medical Practice 6, no. 8 (2024): 189–93. http://dx.doi.org/10.53469/jcmp.2024.06(08).39.

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Professor Ma Shuanquan believes that the root cause of alopecia lies in the liver, spleen, and kidneys .Insufficient innate endowment, excessive contemplation, or liver and spleen damage, resulting in insufficient liver blood, spleen dysfunction, and Syndrome of deficiency of kidney essence, leads to blood stasis in the hair follicles, blocking the flow of qi and blood, and causing hair follicles to lose nourishment, resulting in androgenetic alopecia. In treatment, Professor Ma divides it into two types based on the differentiation of liver and kidney deficiency and spleen and kidney deficien

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Grushko, Maria Pavlovna, Nadezhda Yurievna Terpugova, and Nadezhda Nickolaevna Fedorova. "Comparative characteristics of the silver crucian carp (Carassius auratus gibelio) internal organs state in the age aspect." Vestnik of Astrakhan State Technical University. Series: Fishing industry 2023, no. 4 (2023): 83–91. http://dx.doi.org/10.24143/2073-5529-2023-4-83-91.

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The histological results of the study of the organs of larvae and mature individuals of the silver crucian carp Carassius auratus gibelio (Bloch, 1782) caught in the reservoirs of the Volga River delta are presented. Analysis the internal organs state and tissues helps to identify physiological disorders and pathologies. Thanks to the histological method, it becomes possible to study the structure of the body at the cellular and tissue level, to determine the development of the pathological process and the degree of damage. For pathomorphological evaluation, the liver, gills, kidneys, spleen,

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Chakraborty, Subhankari Prasad, Santanu KarMahapatra, Sumanta Kumar Sahu, Panchanan Pramanik, and Somenath Roy. "Amelioratory Effect of Nanoconjugated Vancomycin on Spleen during VRSA-Induced Oxidative Stress." Pathology Research International 2011 (July 20, 2011): 1–10. http://dx.doi.org/10.4061/2011/420198.

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Objective. The aim of the present study was to evaluate the possible antioxidant effects of nanoconjugated vancomycin against VRSA infection on select makers of oxidative damage and antioxidant status in spleen. Methods. A coagulase-positive VRSA strain was used for this study. VRSA infection was developed in Swiss mice by intraperitoneal injection of 5 × 106 CFU/mL bacterial solutions. VRSA-infected mice were treated with nanoconjugated vancomycin at its effective dose for 10 days. After decapitation, blood was used for determination of viable bacteria count and spleen was excised from contro

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Diyah Utari, Alfiah Hayati, Inge Permatasari, et al. "Effect of Polystyrene Nanoplastic on Colon, Liver, and Spleen Histopathology of Rats (Rattus norvegicus L.)." LenteraBio : Berkala Ilmiah Biologi 14, no. 2 (2025): 219–28. https://doi.org/10.26740/lenterabio.v14n2.p219-228.

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Polystyrene, when exposed to ultraviolet light, can break down into nanoplastics (NPs), which enter the body and elevate reactive oxygen species, leading to oxidative stress which can damage cell structure and function by causing inflammation, necrosis, and tissue degeneration in target organs such as the colon, liver, and spleen. This study specifically investigates the impact of NPs on rats’ colons, livers, and spleens. The experimental design was completely randomized, comprising one control group and three treatment groups (n=6). The treatment groups were exposed to NPs concentrations of 1

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Chen, Wenqi, Shanshan Chen, Lifang Zhao, et al. "Effects of real-ambient PM_2.5 exposure plus lipopolysaccharide on multiple organ damage in mice." Human & Experimental Toxicology 41 (January 2022): 096032712110615. http://dx.doi.org/10.1177/09603271211061505.

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Background: The toxicological effects of fine particulate matter (PM2.5) on the cardiopulmonary and nervous systems have been studied widely, whereas the study of PM2.5 on systemic toxicity is not in-depth enough. Lipopolysaccharide (LPS) can cause multiple organ damage. The combined effects of co-exposure of PM2.5 plus LPS on the stomach, spleen, intestine, and kidney are still unclear. Purpose: This study was aimed to explore the toxicological effects of co-exposure of PM2.5 and LPS on the different organs of mice. Research Design and Study Sample Using a real-ambient PM2.5 exposure system a

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Saez, Carlin P., Botella A. García, Valladares LI Diez, et al. "Splenic volume as a biomarker of hepatic damage after chemotherapy in patients with resected colorectal liver metastases (CRLM)." Clincal and Translational Oncology 22, no. 7 (2020): 1180–86. https://doi.org/10.1007/s12094-019-02245-1.

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<strong>Background: </strong>Chemotherapy-associated liver injury (CALI) is a matter of concern for hepatobiliary surgeons as it can entail postoperative liver failure after an extensive hepatectomy. Recent studies have taken special interest in liver function parameters which can correlate with CALI to decrease this adverse event. Therefore, the current study investigates the usefulness of splenic volume as a biomarker of CALI through a portal hypertension mechanism, in patients with colorectal liver metastases (CRLM). <strong>Study design: </strong>We carried out a study in patient

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Grunewald, Sabrine Teixeira Ferraz, Alice Belleigoli Rezende, Bárbara Bruna Muniz Figueiredo, et al. "Autotransplantation of Spleen Mitigates Drug-Induced Liver Damage in Splenectomized Mice." Journal of Investigative Surgery 30, no. 6 (2016): 368–75. http://dx.doi.org/10.1080/08941939.2016.1255806.

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Nakajima, Tetsuo, Guillaume Vares, Yasuharu Ninomiya, et al. "Diallyl Disulfide Mitigates DNA Damage and Spleen Tissue Effects After Irradiation." Medical Science Monitor 25 (November 24, 2019): 8920–27. http://dx.doi.org/10.12659/msm.917207.

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