Journal articles on the topic 'Daniellia oliveri (Rolfe'

This study investigated effect of Euphorbia tirucalli extracts on Daniellia oliveri and Ficus capensis woods. Wood samples were purchased and processed into 10 cm x 2 cm x 2 cm dimensions, while plant parts collected were oven dried before extraction. E. tirucalli was screened for phytochemicals. Concentrations of 0.5%, 1% and 2% extracts were prepared by serial dilution. Soligum, methanol and untreated wood samples were used as control. Treated wood samples were laid within 6 x 12 metres field at 1 x 3 metres spacing in a Completely Randomized Design (CRD) in a termitarium and data were taken within 8 weeks. Phytochemical results indicated the presence of alkaloids, phenols, tannins, cardiac glycosides, flavonoids and saponins. Percentage absorption of extracts ranged from 47 - 86 % and 94.00 - 50.67 % in D. oliveri and F. capensis, respectively. Percentage retention of extracts ranged from 10.84 - 2.14 kg/m3 and 11.62 - 7.01 kg/m3 in D. oliveri and F. capensis. Soligum treated wood samples were not attacked throughout the period of study. D. oliveri and F. capensis woods treated with 0.5% E. tirucalli methanol extract were not attached on till the 6th and 8th week respectively. The least percentage weight loss of 5.49 % and 28.32 % were recorded for D. oliveri and F. capensis woods treated with soligum, while, 27.5 5 % and 52.50 % weight loss were recorded for F. capensis and D. oliveri woods treated with 0.5% methanol extract. It was concluded that the use o

Les forêts tropicales regorgent de nombreuses espèces ligneuses dont différents organes contribuent de façon significative à la santé, à l’alimentation des populations locales et à l’économie nationale. Cependant, l’importance socioéconomique de certaines espèces comme D. oliveri reste à déterminer. Ainsi, une étude ethnobotanique, réalisée dans les zones écologiques II et III du Togo a permis de répertorier les usages des or-ganes de D. oliveri par les populations locales. L’objectif de cette étude vise à contri-buer à une meilleure connaissance des usages des produits du D. oliveri en vue de sa meilleure valorisation et de sa gestion durable. Il s’agit d’évaluer la variation des con-naissances endogènes des usages du D. oliveri suivant les caractéristiques socio-démographiques et de déterminer la convergence d’usage interethnique de différentes parties de l’espèce. La démarche méthodologique est basée sur la collecte des données par des enquêtes ethnobotaniques semi-structurées, par interviews individuelles et par focus group de 411 personnes appartenant à 11 ethnies dans soixante-quinze (75) villages. Les résultats de l’étude ont montré que l’espèce est utilisée par les différents groupes sociolinguistiques et socioprofessionnels. Ainsi, 35 usages spécifiques répartis dans 7 catégories d’usage ont été identifiés. Les parties de la plante les plus utilisées sont le bois (84,18 %) et les feuilles (68,37 %). Les résultats montrent aussi une varia-tion significative des connaissances d’usage au sein des 11 ethnies (p ˂ 0,001). Par contre le sexe, la fonction et le niveau d’instruction n’influent pas sur le niveau de connaissance. L’importance des usages des organes de l'espèce témoigne de l'urgence et de la nécessité de la mise en œuvre d’une stratégie d’utilisation rationnelle en vue d’une gestion durable des ressources forestières du Togo.

During a previous study that identified plants used in traditional medicine in Togo to treat infectious diseases, Daniellia oliveri was specifically reported to treat intertrigo and candidiasis. Consequently, to explore the anti-infective potential of this plant, we investigated the antibacterial and the antifungal activity of the plant’s parts, as well as the cytotoxic activities of raw extracts and subsequent fractions, and the chemical composition of the most active fractions. In order to evaluate the antimicrobial activity, MICs were determined using the broth dilution method. Then, the most active fractions were evaluated for cytotoxicity by using normal human cells (MRC-5 cells) via the MTT assay. Finally, the most active and not toxic fractions were phytochemically investigated by GC-MS. Interestingly, all the raw extracts and fractions were active against the bacteria tested, with MICs ranging from 16 µg/mL to 256 µg/mL, while no antifungal activity was observed at 256 µg/mL, the highest tested concentration. Moreover, no toxicity was observed with most of the active fractions. The subsequent chemical investigation of the most interesting fractions led to identifying terpenes, phytosterols, phenolic compounds, and fatty acids as the main compounds. In conclusion, this study demonstrated that D. oliveri possesses valuable antibacterial activities in accordance with traditional use.

Two hundred and ten day-old Arbor acre broiler chicks were used to assess the protein quality of raw and toasted Daniellia oliveri seed meal (DOSM) on performance, haematology, and some biochemical indices. Seven treatment diets that contained 0% (control), 2.5, 5.0 and 7.5% raw DOSM and 2.5, 5.0 and 7.5% toasted DOSM respectively were randomly assigned to seven groups of 30 birds each, replicated thrice with 10 birds per replicate in a completely randomized design. Chemical analysis indicated that raw DOSM contained (% DM) 26.50 crude protein, 6.02 crude fibre, 4.30 ether extract, 4.06 ash and 47.47 carbohydrate. The results of the crude fibre (3.19%), ash (2.8%) and nitrogen free extracts (40.51%) were reduced after toasting while the crude protein (28.60%) and ether extract (7.85%) increased. The raw DOSM contained (mg/100g) tannin (2.23), phytic acid (30.39), oxalate (20.02), hydrocyanide (6.05) and saponin (2.08). Toasting treatment eliminate almost completely the anti nutritional compounds in the seeds. Performance data indicate that body weight gain and feed to gain ratio were significantly (P<0.05) better in broiler chicks fed 0.0, 2.5 % raw and all levels of toasted DOSM diets than those on 5.0 and 7.5% raw DOSM based diets. The results of the packed cell volume, red blood cell count, white blood cell count, haemoglobin, serum protein, albumin, glucose and cholesterol of birds on 0.0 %, 2.5% raw and all levels of toasted DOSM diets did not showed any significant effect (P>0.05) but differed (P<0.05) from those on 5.0 and 7.5% raw DOSM. The inclusion of 5 and 7.5 % raw DOSM significantly (P<0.05) decreased weight gain, feed conversion ratio, nutrient digestibility, haematological and biochemical indices. From the results, it can be concluded that inclusion of 2.50% raw DOSM and up to 7.5% toasted DOSM as a replacement for ground nut meal has no adverse effects on the performance, haematological and serum biochemistry

The study investigated the variation in the physical and mechanical properties <em>A. africana </em>and <em>D. oliveri </em>wood. Factorial design of 2&times;2&times;4 in Completely Randomized Design (CRD) was used. Results showed that percentage water absorption of <em>A. africana </em>recorded 187.9% while <em>D. oliveri </em>had 160.1%. <em>D. oliveri </em>recorded a higher radial shrinkage of -72%. <em>A. africana </em>recorded a higher tensile strength of 2.61N/mm² while <em>D. oliveri </em>recorded 1.81N/mm². <em>D. oliveri </em>recorded significant difference with heartwood recording a higher value of 180.7% compared to the sapwood with 139.5%. The radial shrinkage of <em>D. oliveri </em>had higher shrinkage of -72% while heartwood was 0%. <em>A. africana </em>had 462N/mm²<strong> </strong>and 223N/mm²<strong> </strong>of MOE for heartwood and sapwood while <em>D. oliveri </em>recored 224N/mm²<strong> </strong>and 218N/mm²<strong> </strong>respectively. Heartwood of <em>A. africana </em>had a higher (462N/mm²) value compared to the sapwood (231.7N/mm²). The two-wood species exhibit high tensile strength and are therefore recommended for use in building purposes.

Introduction: Malaria parasite infection has remained a global leading cause of death and disability in which about 50% of the world population is estimated to be at risk, especially in low and middle income countries.&#x0D; Aim: This research is designed to evaluate the pharmacognostic, phytochemical profile, and investigate its antimalarial activity by analysing different hematological indices of the methanolic bark extract of Daniellia oliveri, a plant belonging to the family of fabaceae.&#x0D; Methods: The barks of this plants were collected, cleared, dried, pulverized and sequentially extracted with petroleum ether, n-hexane, ethyl acetate, methanol and aqueous using the soxhlet extractor. Acute toxicity studies (LD50) for the methanol bark extract was studied using standard method. Phytochemical and pharmacognostic screening was carried out using standard methods, its hematological analysis were investigated using standard methods. The antimalarial activity of the methanol bark extract Daniellia oliveri, was evaluated at different doses of 100, 200 and 400mg/kg using in-vivo models.&#x0D; Results: The plant is a tall slender tree with a dark grey colour. The following extractive values were obtained petroleum ether (0.600±0.10), n-hexane (0.667±0.88), ethyl acetate (1.600±0.10), methanol (8.400±0.10) and aqueous (6.200±0.10).The methanol extract had the hightest extractive value and was found to be non-toxic at dose 5000mg/kg. The qualitative and quantitative phytochemical analyses reveals the presence of alkaloids (10.179±0.61), saponins (1.674±0.43), tannins (10.738±0.61), flavonoids (3.923±0.15), steroids (2.665±0.07), phenols (134.604±14.83), terpenoids (22.436±4.87), glycosides (14.485±0.08), reducing sugars (4.138±1.36), soluble carbohydrates but absence of cyanogenic glycosides The pharmacognostic parameters values were obtained as follows, total ash value (5.600±0.10), acid insoluble ash value (2.800±0.88), water soluble ash value (0.500±0.10), moisture content (13.933±0.12), bitterness value , foaming index (less than 100), swelling index (2.867±0.99).&#x0D; Conclusion: This result has shown that the hematological analysis carried out exhibited significant improvement in PCV, RBC and Hb when administered the plant extract compared to the standard group. It exhibited significant increase in platelet and lymphocyte while reduction in neutrophil compared to the standard group. The increased hematological indices indicate a better transportation capacity of the red blood cells and this should be attributed to the antimalarial properties of the extract. Also, the white blood differential count indicates a boost in the immune system of the treated P. berghei infected mice. This study justifies the ethno-medicinal use of D. oliveri in the management of malaria.

Understanding the dynamics and patterns of biodiversity in transition forests is vital in promoting conservation and addressing environmental change issues. This work focused on elucidating the diversity, structure, and carbon potentials of a forest-savannah ecosystem. To achieve this, 8 forest plots that measured 50 m × 50 m each was set up in a forest-savannah landscape and used to identify and measure tree species ≥ 10 cm diameter at breast height (DBH measured at 130 cm). Species importance value was used to summarize the biodiversity patterns and the aboveground carbon estimates were elicited with the allometric equation. 43 species within 22 families were enumerated and the diversity was generally low (ranging from 1.82-2.5). Species such as Daniellia oliveri (Rolfe) Hutch. &amp; Dalziel, Pyrostria guinnensis Comm. ex A. Juss, Dialium guineense Willd. and Margariteria discoidea (Baill.) G.L Webster were the dominant species, and had the highest importance values of 113.06, 55.13, 28.16 and 16.95, respectively, while Allophlus africanus P. Beauv., Annona senegalensis Pers., Anthonatha macrophylla P. Beauv., Ficus capensis Thumb. and Lecaniodiscus cupanioides Planch had the least importance values of 0.16 each. Carbon estimates ranged from 16.43172-42.9298 t/Ha. Most frequent species with higher basal areas no doubt contributed much to the carbon estimates, but did not have higher capacities in storing carbon. Managing the ecosystem with more carbon-dense species was seen as a suitable strategy for addressing environmental change in the ecosystem and region.

Cashew nuts are one of the agricultural products that contribute significantly to Côte d'Ivoire's economic development. However, cashew nut production in Côte d'Ivoire is threatened by anthracnose. Reducing anthracnose proliferation factors could reduce its impact on cashew trees. The aim of the study was to assess the virulence of Colletotrichum sp. isolated from weeds in cashew trees. It assessed the pathogenicity of 12 isolates of Colletotrichum sp. extracted from six weeds on cashew plants. The inocula were prepared by scraping the mycelium of each fungus in 10 ml of sterile distilled water. The spore suspension was collected and calibrated at 4.6.106 conidia/ml using a Malassez cell. This suspension was applied by spraying to the leaves of 30-day-old cashew plants. The parameters assessed were symptom incidence and severity index. All isolates tested induced symptoms characteristic of anthracnose on cashew plants. There was a significant difference between isolates in terms of their virulence. The highest incidence of 90% was obtained on plants inoculated with the ColE2 isolate and the lowest incidence of 30% was obtained on plants inoculated with the ColN3 isolate. The highest severity index of 7.66 was obtained on plants inoculated with the ColE3 isolate and the lowest severity index of 2.00 was obtained on plants inoculated with the ColN3 isolate. These results show that Daniellia oliveri (Rolfe), Vitellaria paradoxa (G), Micuna pruriens (L.), Blighia sapida (K. Koenig), Albizia zygia (DC) and Pterocarpus erinaceus (Poir) are hosts of anthracnose in cashew orchards in Côte d'Ivoire. Their integration into cashew pathogen control strategies is necessary.

Aims: Herbal remedies are known for their anti-inflammatory and antioxidant properties. The aim of this study was to evaluate the antioxidant activities of the aqueous extracts of the bark of the trunk of 10 medicinal plants used in traditional medicine for the management of hepatic pathologies. This is Acacia nilotica (L.) Willd. ex Delile (Fabaceae – Mimosoideae), Adansonia digitata L. (Bombacaceae), Bombax costatum Pellegr. &amp; Vuill. (Bombacaceae), Balanites aegyptiaca (L.) Delile (Balanitaceae), Cassia sieberiana DC. (Fabaceae – Caesalpinioideae), Piliostigma reticulatum (DC.) Hochst. (Fabaceae – Caesalpinioideae) Tamarindus indica L. (Fabaceae – Caesalpinioideae), Daniellia oliveri (Rolfe) Hutch. &amp; Dalziel (Fabaceae – Caesalpinioideae), Khaya senegalensis (Desr.) A.Juss. (Meliaceae) and Gymnosporia senegalensis (Lam.) Loes.) (Celastraceae)..&#x0D; Methodology: In this study, the total phenolic and flavonoid content of the aqueous extracts of the trunk bark of 10 plants were determined and their antioxidant activities by the DPPH and FRAP methods were evaluated. The link between phenolic compounds and antioxidant activity was sought through a regression curve.&#x0D; Results: Acacia nilotica had the best contents of total phenolics and flavonoids respectively with 21.28 ± 0.18 g ETA / 100 g DM and 0.207 ± 0.003 g EQ / 100 g DM. For the evaluation of antioxidant activity, Acacia nilotica also gave the best activities by the DPPH method with a percent inhibition of 1.08 ± 0.03 AAE and a reducing capacity of Fe3 + to Fe2 + of 0.107 ± 0.03 AAE. A strong correlation was found between FRAP and total phenolics (r2 = 0.9559).&#x0D; Conclusion: This study shows that all the plants used for the treatment of liver pathologies had an interesting antioxidant capacity but among these 07 plants had the best activities. In-depth studies on the anti-inflammatory and even hepatoprotective activity of these extracts would justify their use in traditional medicine.

At present, no adequate information on the application of crown-bole diameter model to stand density and stock control for Daniellia oliverii (Rolfe) Hutch and Daviz open grown trees for sustainable forest management in the study area. The species numbers are threatened, because farmers and foresters do not actively plant this tree species. Livestock, fire, and anthropogenic activities are few factors that limit the success of natural regeneration of the species; and is facing regeneration problem. These have led to the species declining in the natural forest areas and the loss of biological values (genetic hereditary). A total of nine blocks as sample plots sizes 100x100 meters were randomly laid. Simple random sampling was used to collect data on tree diameter at breast height (dbh). Dbh was used to estimate crown diameter using a developed simple linear crown-bole diameter model. Based on this finding, dbh distribution was more (42 tree stands) concentrated at the lower diameter class (10 to 30cm) than at the upper diameter class distribution (31 and above). This could be that such tree stands might have been exploited as timber in the ecosystem. Nowadays, trees of smaller dimension are generally logged immediately they are discovered, especially the most economic and desirable species. The status of the tree species was a reversed “J” shaped distribution curve. The reverse ‘J-shape’ diameter distribution indicated healthy recruitment potentials; the lower class diameter tree stands could develop into mature trees and replace the old ones in the future if proper conservation efforts are sustained. Thus, this structure is typical of a natural forest. This finding estimated limiting stocking and stand density required for producing a complete canopy without effect of competition. D. oliverii with diameter 48.7cm would require a stocking of 168 trees per hectare in terms of total occupancy by tree crowns; stand density of 0.00001863m2ha-1 would be needed. Also, tree stands of 80cm dbh would have 73 tree stands limiting stocking, covering a stand density of 0.00005027m2/ha. Linear crown-bole diameter model could simply be used in forest inventory operations for determining the forest stock with less cost and time consuming. More research is needed with a greater variety of site and stand conditions in addition to a greater variety of tree sizes and ages.

Savannas are prominent members of tropical terrestrial ecosystems. Leaf and branch litter fractions were sampled from ten isolated, natural tree stands of Azadirachta indica (A. Juss), Daniella oliveri (Rolfe) Hutch &amp; Dalziel, Parkia biglobosa (Jacq.) Benth.,Prosopis africana (Guill.&amp;Perr.) and Vitellaria paradoxa (Gaertner) F.}, in the dry season. Litterfall samples were analysed for Calcium and Magnesium (Atomic Absorption Spectrophotometry) (AAS), Potassium (Flame Photometry), Nitrate-nitrogen and Phosphate-phosphorus (Colorimetric titration). Results showed that branch litter fractions generally returned higher nutrient content than leaf litter. While, the eco-physiologically significant potassium, nitrate-nitrogen, and magnesium were top of the nutrient return spectrum across the litter fractions, with a prominent nutrient return magnitude in the form of K &gt; NO3-N- &gt; Mg &gt; Ca &gt; PO4 3 -P- . This indicates the biogeochemical significance of tree litter in tropical savanna ecosystems. Equally, the outcomes of this study indicate the ecological significance of tropical savanna tree cover in litterfall production, decomposition, as well as base content supply and cycling, for soil fertility.

The contemporary global economic meltdown has devastating effect on the economy of most rural people in Africa in general and Nigeria in particular. The frantic search for alternative source of national revenue aside from oil and gas has become imperative for economic emancipation of Nigerians. Knowledge of plants foraged by bees for pollen and nectar becomes a panacea to this challenge. This study analysed the pollen spectrum of four honey samples collected from Southern Nigeria in order to determine the richness of the honey plants in the area, and to highlight the potential of these species in apicultural entrepreneurship in Nigeria for green growth economy, using Shannon-Wiener Diversity Index after a standard acetolysis method. A total number of 39 palynotaxa belonging to 21 plant families and distributed in 39 genera were identified. Fabaceae had the highest plant species (11 species), followed by Euphorbiaceae (5 species). The study revealed that Elaeis guineensis Jacq, Anacardium occidentale L. Diospyros mespiliformis Hochist ex ADC, Alchornea cordifolia (Muell)Arg, Daniella oliveri (Rolfe) Hutch &amp; Dalz, Irvingia wombolu Okafor ex Baill, Treculia africana Decne, Nauclea latifolia Smith and Crossopteryx febrifuga Afzil ex Benth, were the dominant honey plants. The palynotaxa spectrum did not vary greatly in the four samples; however, Shannon diversity index was low to moderate (H= 2.7 -3.1). This baseline information has provided opportunity and amazing potentials for apicultural enterprise in these areas. However, most of these honey plants are rare, threatened and endangered. This calls for urgent conservation strategies by all players. Policy programmes could increase production and productivity of hive products through capacity- building for local populace.

Abstract Background: Adjuvant ET reduces breast cancer recurrence and increases overall survival among patients with early-stage ER+ breast cancer, however a suboptimal number of patients in fact takes oral medicine as prescribed. In Brazil, there is a paucity of data about adherence to adjuvant ET. This study aims to evaluate adherence to adjuvant ET in Brazilian women with early breast cancer and to evaluate clinical and sociodemographic characteristics associated with higher or lower adherence. Methods: Women with history of early-stage ER+ invasive carcinoma of the breast on adjuvant ET for at least 6 months were invited to participate of this study. Adherence was assessed with questionnaire Morisky Medication Adherence Scale (MMAS-8) and high adherence was defined by a MMAS-8 score=8. Demographic and medical information, site of treatment (private versus public), degree of education (completed high school vs not) were reviewed from medical records. Quality of life was assessed using EORTC QLQ C30 and BR-23 forms, sexuality was evaluated with the Female Sex Function Index questionnaire. Additionally, patients were interviewed about return to work. Data collection was done with RedCap software. Qualitative variables were compared between groups using the Chi-square or exact Chi-square test and for quantitative variables the non-parametric Mann-Whitney test was used. Multivariable analysis was performed using Poisson regression. P &amp;lt; 0.05 was considered significant. Analyzes were performed in SAS 9.4. Results: From June 2021 to May 2023, a total of 461 women with ER+ early-stage breast cancer from 12 Brazilian institutions were included in this analysis. The mean age was 56.0 years (range 22-93), 47.7% were non-white and 38.7% were premenopausal. A total of 233 women (50.6%) had private insurance and the remaining were treated in public institutions. Median duration of ET use was 2.78 years (range 6 months- 9.61 years). High adherence to adjuvant endocrine therapy was present in 55.7% of patients. Median age of high adherent woman was higher than low adherent (p=0.005). Factors significantly associated with high adherence were no use of ovarian suppression (p=0.0095), use of anti-Her2 therapy (p=0.0462). Furthermore, higher scores for EORTC QLQ-C30 global health status (p=0.017) and in specific domains, including role functioning (p=0.007), emotional functioning (p&amp;lt; 0.0001), cognitive functioning (p&amp;lt; 0.001), social functioning (p = 0,0005), higher scores for EORTC BR23 body image (p&amp;lt; 0.001) and future perspective (p = 0.0198) were also associated with high adherence. Higher EORTC QLQ-C30 cognitive function score was the only variable associated with high adherence (p &amp;lt; 0.0001) to ET in multivariate model. Conclusion: Using the MMAS-8, only 55.7% of Brazilian women with stage I-III ER+ breast cancer reported high adherence to endocrine therapy. This suboptimal adherence rate leads to important questions such as the impact on the prognosis of this population Charactheristic with adjusted prevalence ratio for the occurrence of High adherence PR: Prevalence ratio; EORTC: European Organisation for Research and Treatment of Cancer Citation Format: Daniele Assad-Suzuki, Heloísa Resende, Danielle Santos, Fernanda Moura, Sulene Oliveira, Andrea Shimada, Anna Luiza Galvão, Bruno Souza, Amanda Castro, Monalisa Andrade, Yuri Beckedorff, Maria Cristina Magalhães, Cristiano Souza, Carlos Paiva, Daniela Pereira, Angelica Rodrigues, Daniela Rosa, Romualdo Barroso-Sousa. Suboptimal adherence to adjuvant endocrine therapy (ET) in Brazilian women with early-stage estrogen receptor-positive (ER+) breast cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-12-04.

Abstract Background: There is a significant scarcity of quality of life (QOL) data among the Brazilian population with breast cancer. This study aims to evaluate QOL in Brazilian women with early breast cancer treated with adjuvant endocrine therapy (ET) and to explore its relationships with patients’ clinical and social characteristics, type and duration of endocrine therapy and type of healthcare insurance. Methodology: Women with a history of early-stage estrogen-receptor positive invasive carcinoma of the breast on adjuvant endocrine therapy for at least 6 months were invited to participate of this study. QOL assessment was conducted using the EORTC QLQ-C30 and EORTC QLQ-BR23 questionnaires. Demographic and medical information were collected from medical records. Data collection performed using RedCap software. Qualitative variables were compared between groups using the Chi-square or exact Chi-square test and for quantitative variables the non-parametric Mann-Whitney test was used. Multivariable analysis was performed using Multiple linear regression models with Stepwise procedure. P &amp;lt; 0.05 was considered significant. Analyzes were performed in SAS 9.4. Results: From June 2021 to May 2023, a total of 461 women with ER+ early-stage breast cancer from 12 Brazilian institutions were included in this analysis. A total of 233 women (50.54%) were treated in private institutions. Mean age was 56.02 years (range 22-93), 47.69% were non-white and 38.7% were premenopausal. A total of 62.34% had prior lumpectomy, 43.1% had tumor stage II, 61.69% received prior chemotherapy and 15.18% were HER2 positive. Regarding ET, 45.2% were on aromatase inhibitors (AI), 40.61% on tamoxifen (TMX) and 14.19% on ovarian function suppression plus ET (OFS). Median duration of ET use was 2.78 years. From the adjustment of the multiple regression model, it was found that the variable patients with a higher educational level were a significant predictor for the Physical Functioning score (p &amp;lt; 0.0001). The Role Functioning score had the variables treatment in a private hospital (p = 0.0462) and a higher educational level (p = 0.0357) as significant predictors. The variables age &amp;gt; 60 years (p = 0.0006) and marital status: single (p = 0.0267) were significant predictors for the Emotional Functioning score. Cognitive Functioning was correlated with the variables age &amp;gt; 60 years (p &amp;lt; 0.0001) and treatment duration &amp;lt; 2 years (p = 0.0475). Social Functioning had significant predictors such as hormone therapy with AI (p = 0.0305) and hormone therapy with TMX (p = 0.0267) when compared to OFS, as well as treatment duration &amp;lt; 2 years (p = 0.0175). The variable age &amp;gt; 60 years was a predictor for the Fatigue score (p = 0.0233). The Pain score correlated with variables such as higher educational level (p = 0.0003) and treatment duration &amp;lt; 2 years (p = 0.0032). The variables treatment in a public hospital (p = 0.0066), age &amp;lt; 60 years (p = 0.0471), and treatment duration &amp;lt; 2 years (p = 0.0054) were predictors for a higher Arm Symptoms score. Regarding the Breast Symptoms score, the variables treatment in a public hospital (p = 0.0005), Caucasian ethnicity (p = 0.0006), radiation therapy (p = 0.0098), and treatment duration &amp;lt; 2 years (p = 0.0203) were predictors for the total score. Body Image correlated with variables such as age &amp;gt; 60 years (p = 0.0322), surgical approach: mastectomy (p = 0.0445), tumor size &amp;lt; 50mm (p = 0.0446), and radiation therapy (p = 0.0405). The Global health status score did not correlate with any variable. Conclusion: Lower educational level, age&amp;lt; 60 years, duration of ET less than 2 years had a significant impact in many domains of QOL. Radiotherapy was the treatment modality with more impact in QOL scores. The identification of modifiable factors related to QOL in this study provides valuable insights for the development of a customized intervention in Brazilian population. Citation Format: Danielle Santos, Cristiano Souza, Maria Cristina Magalhães, Daniela Pereira, Fernanda Moura, Sulene Oliveira, Anna Luiza Galvão, Bruno Souza, Amanda Castro, Monalisa Andrade, Andrea Shimada, Yuri Beckedorff, Carlos Paiva, Heloísa Resende, Angelica Rodrigues, Daniela Rosa, Daniele Assad-Suzuki, Romualdo Barroso-Sousa. Quality of life in Brazilian women with early breast cancer on adjuvant endocrine therapy [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-11-10.

Editorial – Revista Ambiente Contábil – Volume 14 – Número 1 – Ano 2022 (Jan./Jun. 2022)&#x0D; A Revista Ambiente Contábil (Ambiente) apresenta na sua 27ª edição 19 (dezenove) artigos que tratam de assuntos relevantes para a área contábil; 01 (uma) resenha de livro e 15 (quinze) artigos no idioma inglês (versão de artigos submetidos em português).&#x0D; Seção 1: Contabilidade Aplicada ao Setor Empresarial&#x0D; Artigo 1 - Aplicabilidade dos modelos CAPM local, CAPM local ajustado e CAPM ajustado híbrido ao mercado brasileiro de Vandliny Paiva Martins Teixeira, Moisés Ferreira da Cunha e Thaisa Renata dos Santos com o objetivo de verificar a aplicabilidade dos modelos CAPM local, CAPM Local Ajustado e CAPM Ajustado Híbrido ao mercado brasileiro, a partir da análise de suas respectivas premissas e, adicionalmente, verificar a existência de diferenças estatísticas significativas entre os modelos.&#x0D; Artigo 2 - Gerenciamento de resultados e de capital por bancos latino-americanos com instrumentos financeiros José Alves de Carvalho, Júlio César Gomes Mendonça, Maurício Soares de Faria Júnior e José Alves Dantas com o objetivo de avaliar se os bancos da América Latina utilizam os ganhos e perdas não realizados com instrumentos financeiros, registrados como outros resultados abrangentes, com o objetivo de gerenciamento de resultados e de capital regulatório.&#x0D; Artigo 3 - Cultura organizacional e desempenho financeiro: evidências em empresas listadas no Índice Brasil 100 de Leonardo Portella Ilowski, Iago França Lopes, Cintia Lopes da Silva Vieira, Danieli de Assis Machado, Ruberval Gonçalves de Matos e Nayane Thais Krespi Musial com o objetivo de analisar a relação entre cultura organizacional e desempenho financeiro de empresas listadas no IBrX 100.&#x0D; Artigo 4 - Impacto da exclusão do ICMS da base de cálculo do PIS e da COFINS: estudo sobre a decisão do STF e seus efeitos em uma empresa do segmento alimentício de Jéssica Andressa Zago, Letícia Twardowski da Silva e Vitor Paulo Rigo com o objetivo de apresentar o impacto da decisão proferida pelo Supremo Tribunal Federal que exclui o ICMS da base de cálculo do PIS e da COFINS e demonstrar o montante dessas contribuições a serem restituídas por uma empresa do setor alimentício, enquadrada no regime do Lucro Real.&#x0D; Artigo 5 - Práticas de responsabilidade socioambiental e o desempenho organizacional em companhias abertas de Naline Tres, Claudia Dalla Porta, Sady Mazzioni, Cristian Bau Dal Magro e Daniela Di Domenico com o objetivo de analisar a relação entre as práticas de responsabilidade socioambiental no desempenho das companhias abertas listadas na [B3].&#x0D; Artigo 6 - Agressividade tributária nas empresas de capital aberto que atuam em mercado regulado de Thaís Salvatori França e Francisco Antonio Bezerra com o objetivo de identificar se o mercado regulado por intermédio de suas agências é fator determinante para uma postura de menor agressividade tributária nas empresas.&#x0D; Artigo 7 - Avaliação da condição econômico-financeira de operadoras brasileiras de planos de saúde: uma nota sobre finanças e regulação de Carlos Henrique Rocha, Gladston Luiz da Silva e Paulo Augusto Pettenuzzo de Britto com o objetivo de avaliar o desempenho econômico-financeiro de operadoras brasileiras de planos de saúde e investigar possíveis fontes de variações relativas dos índices estudados. O artigo discute, ainda, a questão da regulação a partir da análise econômico-financeira dos entes regulados.&#x0D; Artigo 8 - O impacto do uso da tecnologia no desempenho da produção leiteira: manejo tradicional, compost barn e free stall de Ana Maria Meinl e Euselia Paveglio Vieira com o objetivo de analisar a contribuição do uso de tecnologias e sistemas de produção diferenciados na formação dos resultados da atividade leiteira de três propriedades rurais, que utilizam diferentes sistemas produtivos e estão localizadas na região Noroeste do Estado do Rio Grande do Sul.&#x0D; Artigo 9 - Análise da relação da quantidade de participantes ativos das entidades fechadas de Previdência Complementar (EFPC) com o ambiente socioeconômico de Ivone Pedro de Lima, Elis Regina de Oliveira, Geovane Camilo dos Santos, Dryelle Laiana de Jesus Silva dos Santos e Élcio Dihl Oliveira com o objetivo de analisar a associação entre a quantidade de participantes ativos de planos de previdência, vinculados às EFPC, e as variáveis: PIB, taxa de desocupação, inflação (INPC), taxa de juros (Selic), quantidade de EFPC e fluxo de entrada e saída de participantes ativos.&#x0D; Artigo 10 - Transparência corporativa e desempenho: qual o papel das mulheres nessa relação? de Verivaldo Alves de Freitas, Messias Elmiro Gomes Loiola de Oliveira, Jislene Trindade Medeiros e Márcia Martins Mendes De Luca com o objetivo de investigar a influência da participação feminina no conselho de administração na relação entre a transparência corporativa e o desempenho de empresas brasileiras.&#x0D; Artigo 11 - Análise da viabilidade econômica, em condições de riscos, do sistema de confinamento utilizado para a terminação de bovinos no estado de São Paulo, Brasil de Kaio Expedito Rodrigues Queiroz, Janderson Damaceno dos Reis e André Rozemberg Peixoto Simões com o objetivo de avaliar a sensibilidade e a viabilidade econômica do sistema de confinamento utilizado para a engorda de bovinos tomando como referência uma propriedade localizada no norte do estado de São Paulo, Brasil.&#x0D; &#x0D; Artigo 12 - Avaliação do nível de disclosure de arrendamentos mercantis nas demonstrações contábeis de empresas de consumo não-cíclico: um estudo sob a luz do novo IFRS 16 de Ícaro Luiz de Sousa Silva, Alexandre Gonzales e Fernando de Almeida Santos com o objetivo de averiguar o nível de disclosure contábil demandado de acordo com o IFRS16 nas empresas de capital aberto na B3, mais precisamente no segmento de consumo não-cíclico.&#x0D; Artigo 13 - Desempenho dos maiores bancos brasileiros: um estudo sobre o impacto da crise subprime de Cristiana Maria Coeli e Vanessa Martins Pires com o objetivo de analisar o impacto da crise subprime no desempenho dos maiores bancos brasileiros, utilizando indicadores contábeis que permitem mensurar o comportamento dos índices de inadimplência, a evolução das despesas com Provisão para Devedores Duvidosos (PDD), do volume de ativos totais e dos índices de rentabilidade.&#x0D; Seção 2: Contabilidade Aplicada ao Setor Público e ao Terceiro Setor&#x0D; Artigo 1 - Emenda Constitucional n.º 95/2016 e seu impacto em uma universidade federal de Viviane Amorim de Oliveira, Eduardo Tadeu Vieira, Tiago Mota dos Santos e Jorge Katsumi Niyama com o objetivo de avaliar, em um cenário hipotético e por meio de abordagem retrospectiva, no período de 1995 a 2017, os efeitos da Emenda Constitucional n.º 95/2016 sobre o orçamento da Universidade de Brasília, a partir de um modelo econométrico de previsão de despesa paga.&#x0D; Artigo 2 - Impactos na eficiência do gasto público na educação fundamental dos municípios paulistas por meio das categorias do elemento da despesa de Gabriel Santana Machado, Jaime Crozatti, Vinicius Macedo de Moraes, Bianca de Oliveira e Carlos Eduardo de Oliveira Silva com o objetivo de mensurar os impactos dos gastos públicos na educação fundamental dos municípios paulistas sobre a eficiência do gasto público educacional.&#x0D; Artigo 3 - Eficiência do sistema de transporte metroferroviário brasileiro: uma aplicação da Análise Envoltória de Dados de Maria Cecilia da Silva Brum e Tiago Wickstrom Alves com o objetivo de analisar a eficiência técnica das empresas metroferroviárias brasileiras.&#x0D; &#x0D; Seção 3: Pesquisas de Campo sobre Contabilidade (Survey)&#x0D; Artigo 1 - Controles internos para o gerenciamento de riscos: percepção de auditores e gestores de Isadora Marques dos Santos, Rosângela Queiroz Souza Valdevino, Rosilania Silva de Queiroz, Adriana Martins de Oliveira, Letícia Jéssica Freitas de Oliveira e Meskla Gislainy Marques da Silva com o objetivo de analisar a percepção dos auditores e gestores em relação aos controles internos no gerenciamento de riscos nas empresas.&#x0D; Artigo 2 - Sistema eletrônico de informações em uma instituição pública do estado de Pernambuco: uma análise da aceitação e uso do sistema de Antônio Alves da Silva, Paulo de Tasso de Souza Junior e Alessandra Carla Ceolin com o objetivo de promover uma avaliação da aceitação e uso da tecnologia implantada (Sistema Eletrônico de Informações) em uma instituição pública do estado de Pernambuco, sob a perspectiva dos usuários internos do sistema à luz da Teoria Unificada de Aceitação e Uso da Tecnologia (Venkatesh, Morris, Davis &amp; Davis, 2003).&#x0D; Artigo 3 - Avaliação da utilização do Portal Capes de periódicos na ótica dos usuários pesquisadores em administração e contabilidade com base na escala SERVQUAL de Ana Carolina Vasconcelos Colares e Cássia de Oliveira Ferreira com o objetivo de avaliar a utilização do Portal Capes de Periódicos na ótica dos usuários pesquisadores em administração e contabilidade, e investigar a relação entre a satisfação do usuário com as cinco dimensões do modelo SERVQUAL de avaliação de serviços.&#x0D; Seção 4: Casos de Ensino Aplicados a Contabilidade&#x0D; Não houve submissão.&#x0D; Seção 5: Resenhas de Teses, Dissertações e Livros sobre Contabilidade&#x0D; Resenha 1 - Resenha do livro: Escola Nacional de Administração Pública (ENAP). Capacidades Estatais para Produção de Políticas Públicas: Resultados do Survey sobre o Serviço Civil no Brasil. Brasília: Enap, 2018, 74 páginas, Cadernos Enap, 56, ISSN: 0104-7078&#x0D; Autores: Everaldo Nogueira de Souza e Antônio Carlos Brunozi Júnior&#x0D; Seção 6: Banco de Dados (Arquivos suplementares em Excel)&#x0D; Não houve submissão.&#x0D; Seção 7: Internacional (S7)&#x0D; ENGLISH&#x0D; Section 1&#x0D; Article 2 (Section 1) – Earnings and capital management by Latin American banks through financial instruments of José Alves de Carvalho, Júlio César Gomes Mendonça, Maurício Soares de Faria Júnior and José Alves Dantas. The purpose of this study is to assess whether banks in Latin America make use of unrealized gains and losses through financial instruments, recorded as other comprehensive income, when engaging in earnings management and capital resource allocation.&#x0D; Article 3 (Section 1) – Organizational culture and financial performance: evidence in companies listed in the Brazil Index 100 of Leonardo Portella Ilowski, Iago França Lopes, Cintia Lopes da Silva Vieira, Danieli de Assis Machado, Ruberval Gonçalves de Matos and Nayane Thais Krespi Musial. The study investigates the relationship between organizational culture and financial performance of companies classified in the IBrX 100.&#x0D; Article 4 (Section 1) - Impact of the exclusion of ICMS from PIS and COFINS calculation base: study on the STF decision and its effects on a food company of Jéssica Andressa Zago, Letícia Twardowski da Silva e Vitor Paulo Rigo. This study aims to present the impact of the decision issued by the Supreme Federal Court that excludes ICMS from PIS and COFINS calculation basis and to present the amount of these contributions to be refunded by a company in the food sector, within the framework of the actual profit method.&#x0D; Article 5 (Section 1) - Socio environmental responsibility practices and organizational performance in public companies of Naline Tres, Claudia Dalla Porta, Sady Mazzioni, Cristian Bau Dal Magro and Daniela Di Domenico. Analyze the relationship between socio-environmental responsibility practices in the economic and financial performance of companies listed in [B3].&#x0D; Article 6 (Section 1) - Tax aggressiveness in publicly traded companies operating in a regulated market of Thaís Salvatori França and Francisco Antonio Bezerra. The research aims to identify whether the regulated market through its agencies is a determining factor for a posture of less tax aggressiveness in companies.&#x0D; Article 7 (Section 1) – An appraisal of Brazilian private health plan operators’ economic-financial conditions: a note on finance and regulation of Carlos Henrique Rocha, Gladston Luiz da Silva and Paulo Augusto Pettenuzzo de Britto. This study aims to evaluate the economic-financial performance of Brazilian private health plan operators and investigate possible sources of relative variations in the studied indicators. The article also discusses the question of regulation based on an economic-financial analysis of the regulated entities.&#x0D; Article 8 (Section 1) – The impact of using technology on the performance of dairy production: traditional management, compost barn and free stall of Ana Maria Meinl and Euselia Paveglio Vieira. This theoretical application seeks to analyze the contribution of the use of differentiated technologies and systems in the formation of the results of the dairy activity of three rural properties, which use different productive systems and are located in the Northwest region of the State of Rio Grande do Sul. Calculation of costs of the three properties using the absorption costing method, in order to know the respective results in each production system analyzed. &#x0D; &#x0D; Article 10 (Section 1) – Corporate transparency and performance: what is the role of women in this relationship? of Verivaldo Alves de Freitas, Messias Elmiro Gomes Loiola de Oliveira, Jislene Trindade Medeiros e Márcia Martins Mendes De Luca. In this study, we investigated the influence of female board membership on the relationship between corporate transparency and performance in Brazilian public firms.&#x0D; Article 11 (Section 1) – Analysis of economic viability under risk conditions of a beef cattle feedlot system in São Paulo State, Brazil of Kaio Expedito Rodrigues Queiroz, Janderson Damaceno dos Reis e André Rozemberg Peixoto Simões. Assess the sensitivity and economic viability of the beef cattle feedlot system using as a reference a farm located in northern São Paulo State, Brazil.&#x0D; Article 12 (Section 1) – Disclosure analysis of leases in financial statements of non-cyclical consumer companies: a study considering IFRS 16 of Ícaro Luiz de Sousa Silva, Alexandre Gonzales and Fernando de Almeida Santos. This article then aims to ascertain the level of accounting disclosure required under the IFRS 16 in publicly traded companies in B3, more precisely in the non-cyclical consumer segment. &#x0D; Section 2&#x0D; Article 1 (Section 2) - Constitutional Amendment 95/2016 and its impact on a federal university of Viviane Amorim de Oliveira, Eduardo Tadeu Vieira, Tiago Mota dos Santos and Jorge Katsumi Niyama. To evaluate the effects of Constitutional Amendment 95/2016 on the budget of the University of Brasília in the period from 1995 to 2017, based on an econometric model for forecasting expenditure, using a hypothetical scenario and a retrospective approach.&#x0D; Article 2 (Section 2) - Impacts on the efficiency of public expenditure in the fundamental education of São Paulo cities through the expenditure element categories of Gabriel Santana Machado, Jaime Crozatti, Vinicius Macedo de Moraes, Bianca de Oliveira and Carlos Eduardo de Oliveira Silva. This study aims to measure the impact of public spending on basic education in São Paulo cities on the efficiency of public educational expenditure.&#x0D; Article 3 (Section 2) - The efficiency of Brazilian railway system: an application of Data Envelopment Analysis of Maria Cecilia da Silva Brum and Tiago Wickstrom Alves. To analyze the technical efficiency of Brazilian railway companies. &#x0D; Section 3&#x0D; Article 1 (Section 3) - Internal controls for risk management: perception of auditors and managers of Isadora Marques dos Santos, Rosângela Queiroz Souza Valdevino, Rosilania Silva de Queiroz, Adriana Martins de Oliveira, Letícia Jéssica Freitas de Oliveira and Meskla Gislainy Marques da Silva. This article aims to analyze the perception of auditors and managers in relation to internal controls in risk management in companies.&#x0D; Article 3 (Section 3) - Evaluation of the use of the Capes Portal of journals from the perspective of research users in administration and accounting based on the SERVQUAL scale of Ana Carolina Vasconcelos Colares and Cássia de Oliveira Ferreira. The objective of this research is to evaluate the use of the Capes Portal of Periodicals from the perspective of research users in administration and accounting, and to investigate the relationship between user satisfaction with the five dimensions of the SERVQUAL model of service evaluation.&#x0D; &#x0D; Boa leitura. Cordiais saudações!&#x0D; &#x0D; Prof. Dr. Maurício Corrêa da Silva&#x0D; Editor Gerente da Revista Ambiente Contábil&#x0D;

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Contributes of corporate social performance and ethical reputation for the attraction of future employees (pp. 192-197)Ana Patrícia Duarte, Vítor Hugo Silva, Eduardo Simões e José Gonçalves das Neves Complexidade da conceção de parentalidade em famílias adotivas (pp. 198-201)Lília Silva, Cristina Nunes e Ana Susana Almeida O papel da felicidade na relação entre a liderança autêntica e a criatividade (pp. 202-209)Neuza Ribeiro, Ana Suzete Semedo e Arnaldo Coelho When a relationship of intimacy turns into homicide: About a case study (pp. 210-220)Andreia Azeredo, Diana Moreira e Fernando Almeida Onde estão as árvores? Análise exploratória de mapas mentais de um Campus universitário (pp. 221-226)Joana Bizarro, Gabriela Gonçalves, Catarina Silva, Patrícia Silva e Jacinta Fernandes O que pode fazer António? Os serviços de saúde mental nos processos de integração comunitária (pp. 227-231)Maria F. Jorge-Monteiro e José Ornelas Estudo da relação entre a confiança grupal e a satisfação dos membros numa perspetiva longitudinal e dinâmica (pp. 232-236)Ana Isabel de Gouveia Rente, Paulo Renato, Teresa Rebelo e Isabel Dimas Ser estudante de doutoramento: A relação de orientação e a perceção de desenvolvimento pessoal (pp. 237-242)José Simões e Madalena Melo Estudo inicial de adaptação e validação da Decision-Specific Reinvestment Scale numa amostra de atletas Portugueses (pp. 243-249)José Fernando Cruz, Patrícia Simões, Rui Sofia e Francisco J. Rodrigues Obesidade na adolescência: O papel da actividade física nas funções executivas (pp. 250-253)Fátima Gameiro, Beatriz Rosa e António Palmeira Observação de Bullying: Avaliação, sensibilidade moral e motivação para ajudar as vítimas (pp. 254-260)Sónia Pereira e Madalena Melo Relação entre cronótipo e desempenho escolar em estudantes portugueses dos 2.º e 3.º ciclos do ensino básico: Resultados preliminares (pp. 261-267)José Martins e Marco Miguel Bento Promoção da literacia emergente à luz do modelo Response to Intervention (RTI) (pp. 268-277)Marco Bento, Diana Alves, Orlanda Cruz e Ana Paula Silva Estudantes Cabo-Verdianas em Portugal: Novos perfis migratórios (pp. 278-285)Luciana Soares e Conceição Nogueira Uma perspectiva ecológica sobre o papel da qualidade da casa e da escolha na promoção do recovery e da integração comunitária no programa Casas Primeiro – Lisboa (pp. 286-291)Paulo Martins e José Ornelas “Dream Teens”: os jovens na promoção da saúde do seu grupo de pares (pp. 292-296)Cátia Branquinho, Margarida Gaspar de Matos e Projeto Aventura Social Dream Teens O recurso à suspensão provisória do processo em crimes de violência doméstica: Perceções e decisões dos/as magistrados/as (pp. 297-300)Sofia Jamal e Celina Manita The role of independent housing and working in the promotion of personal empowerment in people with mental illness (pp. 301-307)Luis Sá Fernandes e José Ornelas Sentimento de culpa e o suporte social no autocuidado das cuidadoras informais familiares (pp. 308-312)Lisneti Castro, Dayse Neri de Souza, Anabela Pereira, Evelyn Santos, Roselane Lomeo, Laurinda Mendes, Helena Teixeira, Cláudio Guimarães, Maria do Céu Ferreira e Ana Catarina Leite A Perturbação de Stresse Pós-Traumático (PTSD) em Portugal: Relação com a estima de si e o coping (pp. 313-319)João Hipólito, Odete Nunes, Rute Brites, Tito Laneiro, António Correia e Carlos Anunciação Sentido psicológico de comunidade: Um estudo multimétodo num contexto associativo (pp. 320-328)Olga Oliveira Cunha e José Henrique Ornelas

Abstract Background: SERENA-1 (NCT03616587) is a Phase 1, multi-part, open-label study of camizestrant in women with ER+/HER2− advanced breast cancer. Parts A/B and C/D (escalation/expansion) examined camizestrant as monotherapy and in combination with palbociclib respectively and have been presented previously.1,2 Here we present data from parts G/H which examined camizestrant in combination with abemaciclib. Methods: The primary objective was to determine the safety and tolerability of camizestrant 75 mg once daily (QD) in combination with abemaciclib 150 mg twice daily (BID). Secondary objectives included investigation of anti-tumor response and pharmacokinetics (PK). Participants were previously treated women of any menopausal status (pre-menopausal women received this combination alongside ongoing ovarian function suppressors). Prior treatment with ≤2 lines of chemotherapy in the advanced setting was permitted. There was no limit on the number of lines of prior endocrine treatment in the advanced setting; previous treatment with CDK4/6 inhibitors (CDK4/6i) and fulvestrant was permitted. Results: As of 1st June 2022, 24 patients had received camizestrant in combination with abemaciclib with a median 7.7 month follow up. Tolerability of the combination of camizestrant and abemaciclib was consistent with that of each drug individually. No patient required camizestrant dose reduction. All camizestrant-related heart rate decreases were Grade 1 (asymptomatic). PK data for camizestrant in combination with abemaciclib were consistent with camizestrant as monotherapy and published abemaciclib steady-state PK data, indicating no clinically relevant drug-drug interaction. In these heavily pre-treated patients (46% prior chemotherapy, 75% prior CDK4/6i, 54% prior fulvestrant; all in the advanced disease setting) and of whom 67% had visceral metastases, the objective response rate was 5/19 (26.3%), the clinical benefit rate at 24 weeks was 16/24 (66.7%) and the median progression-free survival had not been reached, with 8/24 patients experiencing a progression event. These data support the use of camizestrant 75 mg QD combined with the approved abemaciclib dose. Conclusions: Camizestrant 75 mg QD in combination with abemaciclib 150 mg BID was well tolerated with encouraging clinical activity. The inclusion of this regimen in the ongoing Phase 3, SERENA-6 trial 3, of camizestrant combined with CDK4/6i versus an aromatase inhibitor, will further clarify the role of this combination in the treatment of patients with ER+/HER2− advanced breast cancer with tumors expressing ESR1 mutations. References 1. Baird R, Oliveira M, Ciruelos Gil EM, et al. SABCS 2020 Virtual Meeting. Abstract PS11-05. 2. Oliveira M, Hamilton EP, Incorvati J, et al. J Clin Oncol 40, 2022 (suppl 16; abstr 1032). 3. SERENA-6 trial. Available at https://clinicaltrials.gov/ct2/show/NCT04964934 We acknowledge Helen Heffron, PhD, from InterComm International who provided medical writing support funded by AstraZeneca. Citation Format: Nicholas Turner, Christos Vaklavas, Emiliano Calvo, Javier Garcia-Corbacho, Jason Incorvati, Manuel Ruiz Borrego, Chris Twelves, Anne Armstrong, Begoña Bermejo, Erika Hamilton, Mafalda Oliveira, Eva Ciruelos, Peter Kabos, Manish R Patel, Maria Borrell, Howard Burris, Bruno de Paula, Alejandro Falcon, Cristina Hernando, Irene Moreno, Ciara S. O’Brien, Elena Shagisultanova, Ivan Victoria Ruiz, Judy S. Wang, Mei Wei, Tim Brier, Danielle Carroll, Carmela Ciardullo, Lisa Gibbons, itziar irurzun-Arana, Tony Jack, bistra kirova, Teresa Klinowska, Justin Lindemann, Julie Maidment, Alastair Mathewson, Rhiannon Maudsley, Robert McEwen, Christopher Morrow, Andy Sykes, Richard D. Baird. SERENA-1: Updated analyses from a Phase 1 study of the next generation oral selective estrogen receptor degrader camizestrant (AZD9833) combined with abemaciclib, in women with ER-positive, HER2-negative advanced breast cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P3-07-28.

Abstract Introduction: Approximately 10% of all neoplasms are influenced by germline mutations in pathogenic or likely pathogenic (P/LP) genes, with a majority of these mutations impacting the development of Hereditary Breast and Ovarian Cancer (HBOC) syndrome. The most common genes involved in HBOC are related to homologous recombination (HR) DNA repair, such as BRCA1, BRCA2, PALB2, CHEK2, ATM, RAD51, and BRIP1. In breast cancer, other genes like PTEN, TP53, CDH1, NF1, STK11, MUTYH, and BARD1 also play a crucial role in developing this neoplasm. Furthermore, the specific type of gene variation is important for understanding the spectrum and phenotype of hereditary cancer itself. Most studies on germline mutations and lifetime cancer risk have been conducted in developed countries. Therefore, the regional impact of specific variants in low and middle-income countries remains under investigation. Thus, we present the spectrum of germline mutations observed in Ceará, a northeastern state of Brazil. Methodology: This retrospective, cross-sectional study was conducted between 2018 and 2024 with patients from a private oncology clinic in Brazil, who met clinical criteria for Hereditary Predisposition Syndromes, specifically Hereditary Breast and Ovarian Cancer, according to the National Comprehensive Cancer Network (NCCN) guidelines. Molecular analyses were performed using a commercial multi-gene cancer panel with next-generation sequencing (NGS) capture panels, which included 27 to 84 genes depending on clinical suspension. These panels were validated for copy number variation and were designed to cover at least each exon and 20 base pairs of the intronic sequences adjacent to the exons. The primary endpoint was the prevalence of Hereditary Breast Cancer genes (BRCA1, BRCA2, PALB2, CHEK2, ATM, RAD51, BRIP1, PTEN, TP53, CDH1, NF1, STK11, MUTYH, and BARD1) in this population and the specific variants of the genes involved. Results: From 1055 patients analyzed, 141 (13.4%) individuals harbored a P/LP variant with 92 (8.7%) families harboring genes associated with an increased risk of HBOC syndrome. The most frequently mutated gene was BRCA1 (34.8%), followed by BRCA2 (15.2%), CHEK2 (14.1%), PALB2 (11.9%) ATM (8.7%), MUTYH (6.5%), RAD51 (4.3%), TP53 (3.3%) and NF1 (1.1%). In BRCA1, c.5074+2T&amp;gt;C (31.3%) was the most common variant, followed by C.5266dup (25.0%) and c.1961dup (12.5%). In BRCA2, the most common variant was c.4808del (35.7%), followed by c.9382 C&amp;gt;T (21.4%), c.2167delA (14.2%), and c.6024dup (14.2%). Within CHEK2, the most common variant was c.846+1G&amp;gt;C (69.2%), followed by c.349A&amp;gt;G (23.1%), and c.593-1 G&amp;gt;T (7.7%). Deletion (Exons 1-10) (27.3%) was the most common variation in PALB2, followed by c.1042C&amp;gt;, c.1240C&amp;gt;T (9.1%). In ATM, was c.1236 (25.0%), c.640del (25.0%) and Deletion (Exons 27-29) (25.0%). In MUTYH cases, it was c.536A&amp;gt;G (50.0%) and c.1187G&amp;gt;A (33.3%). In RAD51D was, c.694 C&amp;gt;T (50.0%). A TP53 founder pathogenic variant (R337H) accounted for 33% of all TP53 P/LP. Conclusion: These findings highlight the genetic diversity in HBOC syndrome and emphasize that regionality plays a crucial role in the distribution and prevalence of specific P/LP variants. Also, this study underscores the importance of conducting germline studies in under-represented populations to understand the landscape of HBOC syndrome better and develop unique prevention strategies. However, further research is needed to explore the underlying factors driving these regional differences and to understand the clinical implications of specific variants identified in this research. Citation Format: Valbert Oliveira Costa Filho, Mariana Macambira Noronha, Pedro Robson Costa Passo, Duílio Reis da Rocha Filho, Leonardo Saraiva Pontes, Victor Queirós Calheiros Campelo Maia, Ormando Rodrigues Campos Junior, Cristiane de carvalho Coutinho Farias, Georgia Fiuza Alencar Araripe, Virginia Moreira Braga, Ingrid Hariman Fonseca da Cunha, Carla Dias, Antônio Bitu dos Santos Filho, Leonardo Atem, Milena Viana de Holanda, Aline Carvalho Rocha, Cárilla Carrascoza Caramuru, Lorena Alves Oliveira da Silva, Paulo Zattar Ribeiro, Ana Lucíola Borges Pinheiro, Eric Lima Freitas Mota, Gabriel Sampaio Feitosa, Ígor Giordan Duarte Jorge, Izaberen Sampaio Estevam, Letícia Pinheiro Amorim, Paulo Eduardo de Oliveira, Kevin Lucas Silva Ribeiro, Carlos Alberto Barbosa Neto, Emmanuel Filizola Cavalcante, Paulo Henrique Walter Aguiar, Gina Zully Carhuancho Flores, Flávio Henrique Cantanhêde Ximenes, Natália Couto Monteiro Feitosa, Everardo Leite Gonçalves, Josmara Ximenes Andrade Furtado, Leandro Jonata de Carvalho Oliveira, Gabriela Carvalho Pinheiro, Marclesson Santos Alves, Francisco Pimentel Cavalcante, Danielle Calheiros Campelo Maia. Genetic Spectrum and Prevalence of Hereditary Breast and Ovarian Cancer Genes in Ceará's Families, Brazil: A Retrospective Study on Germline Mutations and Regional Variants [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P4-02-16.

Abstract Cytotoxic drugs often fail to eradicate cancers due to the presence of treatment-persistent tumor cells that represent a reservoir for relapse. These “residual” cancer cells escape from chemotherapy- induced death by entering a reversible slow proliferation state, known as drug tolerant persister (DTP) state. Although improvement of treatment options achieved a survival benefit, Gastric Cancer (GC) is still endowed with poor prognosis. Surgery and neo/adjuvant chemotherapy remain the keystone of treatment. However, most patients with advanced cancer relapse even after complete surgical resection, suggesting a critical role for DTP cells. We obtained GC DTP cells from primary cells upon first- and second-line chemotherapy regimens (FLOT and FOLFIRI). Cells were treated with doses corresponding to the drug maximal plasmatic concentration. At the end of the treatment, cells were left without drugs (washout). During this window of time, when cells had regrown, they were re-challenged with chemotherapy and resulted still sensitive to the treatments, thus fulfilling the criteria for bona fide DTP cells. GC DTPs showed increased expression of markers associated with gastric stem cells (i.e. LGR5), downregulation of proliferative markers (i.e. Ki67) and decreased levels of PS6, evaluated as a readout of mTOR activation. Interestingly, DTPs resulted positive to X-gal-based β-galactosidase staining, suggesting a chemotherapy-induced senescence-like status. RNA-seq analysis and gene expression arrays allowed the identification of genes specifically down/upregulated in DTP cells. Using the intuitive enrichment analysis web-based tool Enrichr, we discovered that 54/173 of the downregulated genes characterizing the persister state were targets of a single miRNA. By quantitative real-time PCR, we validated the expression of this miR in all the models of FOLFIRI- and FLOT-obtained persister cells and we found it strongly upregulated (up to 8-fold), highlighting its possible contribute in the establishment of the persister state. Since among the target genes of this miR there are genes involved in the Homolougus Recombination (HR) system, we performed TaqMan™ Array assay for Human DNA repair gene expression on FOLFIRI-obtained DTPs. We identified a significant downregulation of genes strictly correlated to the HR machinery, suggesting that the FOLFIRI-induced persister cells can temporarily enter in a “BRCAness” status that may be used for a synthetic lethality approach using PARP inhibitors. Targeting the drug tolerant persister state is an essential approach to diminish cancer cells when they are potentially in their most vulnerable state. Citation Format: Elisabetta Puliga, Lisa Negro, Martina Olivero, Claudia Orrù, Fabrizio Maina, Daniela Conticelli, Simona Corso, Silvia Giordano. Targeting vulnerabilities of drug-tolerant persister cells in gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5882.

Abstract Background: Oncotype DX (ODX) is a genomic signature (GS) for the prediction of risk of recurrence and benefit of chemotherapy (CT) in both node negative (N0) and positive (N1), hormone receptor positive (HR+), HER2 negative (HER2-) early breast cancer (eBC). ODX was not an inclusion criterion in the MonarchE but was one in the Natalee study, in which trials most patients received neo-adjuvant chemotherapy. We aim to evaluate the proportion of patients potentially eligible for adjuvant CDK4/6 inhibitors (CDK4/6i) without CT indication by genomic risk using real-world data from a large dataset of patients from various Brazilian institutions. Methods: Clinicopathologic and ODX information were reviewed for patients with T1-T3, N0-N1, HR+/HER2- eBC who had an ODX performed between 2005 and 2020. Projections of CT indication by genomic criteria were based on TAILORx and RxPONDER data. Projections of adjuvant CDK4/6i indication were based on the MonarchE and Natalee criteria. Results: Of 636 patients, 27.5%/51.8%/20.8% were T1mic-a-b/T1c/T2-3, respectively. 19.5% were grade 1 (G1), 66.9% G2 tumors and 12.9% G3. 74 (11.6%) were N1. The ODX indicated low (&amp;lt; 11), intermediate (11-25) and high ( &amp;gt;25) risk in 117 (18.4%), 408 (64.1%) and 111 (17.5%) patients, respectively. 408 patients (64.2%) had low clinical risk and 228 patients (35.8%) had high clinical risk disease. In the overall cohort, 439 (69%) did not have genomic indication for CT, 25 (3.9%) and 133 (21%) were eligible for adjuvant abemaciclib and ribociclib, respectively. Among patients eligible for adjuvant CDK4/6i, greater than 50% did not meet genomic criteria for recommendation of CT (Table 1). Conclusions: In times of rapid incorporation of both GES (as valuable treatment de-escalation tools) and adjuvant CDK4/6i, our results suggest that a meaningful proportion of patients could be eligible for adjuvant abemaciclib and/or ribociclib independently of CT indication. However, little is currently known about the role of these agents in patients not treated with chemotherapy because they were largely unrepresented in these studies. Proportion of patients eligible for adjuvant CDK4/6i in the overall and non-CT eligible population. CT: chemotherapy Citation Format: Leandro Oliveira, Thais Megid, Daniela Rosa, Daniele Assad-Suzuki, Daniel Argolo, Solange Sanches, Laura Testa, José Bines, Rafael Kaliks, Débora Gagliato, Romualdo Barroso-Sousa, Tatiana Correa, Andrea Shimada, Daniel Batista, Daniel Musse, Marcelle Cesca, Débora Gaudêncio, Larissa Moura, Julio Araujo, Renata Colombo Bonadio, Artur Katz, Max Mano. Real-world eligibility for adjuvant CDK4/6 inhibitors among patients without genomic risk for chemotherapy: a GBECAM multicenter retrospective study [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-16-07.

Die konvergente Medienwelt erweitert die Funktionen, die Medien in den Lebensvollzügen der Menschen haben. Schaltstelle ist dabei das Internet. Als Unterhaltungs-, Informations- und Orientierungsquellen fungieren nicht mehr nur die Massenmedien. Über das Internet werden sie ergänzt und verzahnt mit Angeboten unterschiedlicher Herkunft und Gestalt. Rezeption ist nicht mehr die vorrangige Komponente des Medienhandelns. Das Internet öffnet zusätzlich Kommunikationsräume, die für die Organisation und Gestaltung des Beziehungslebens, für grenzüberschreitenden Austausch über Interessengebiete oder als Ort für die Ratsuche genutzt werden. Darüber hinaus haben sich die Möglichkeiten erweitert, sich auf medialen Wegen öffentlich zu äußern, sich selbst, seine Vorlieben, Meinungen und Talente zu präsentieren. Vor allem die junge Generation konsumiert, was andere auf einschlägigen Plattformen von sich preisgeben und bestückt diese Plattformen selbst mit ihren Äußerungen und Werken. Der erste Fokus dieses Heftes liegt auf der Perspektive der Nutzenden und damit auf dem vielgestaltigenMedienhandeln von Jugendlichen in der konvergenten Medienwelt. Damit setzen sich die ersten fünf Beiträge auseinander. Medienkonvergenz bezeichnet einen Prozess, der die Bedingungen des Medienhandelns vor allem der jungen Generationen ständig verändert. Der Artikel von Ulrike Wagner Jugendkulturellbewegt, massenmedial geprägt – Erweiterungen auf den Wegen durch die konvergente Medienwelt zeigt auf, dass einige Muster konvergenzbezogenen Medienhandelns, die im Jahr 2005 noch wenige Jugendliche zeigten, unter den aktuell analysierten Bedingungen jugendaffiner Internetplattformen im Jahr 2009 an Bedeutung gewonnen haben. Wagner arbeitet Spannungsfelder heraus, die den Nutzenden erweiterte Fähigkeiten abverlangen, zumal sie zunehmend selbst an der Herstellung der konvergenten Medienwelt beteiligt sind. Eine gewichtige Rolle spielen dabei Bezüge zu massenmedialen Inhalten, wie anhand von Selbstdarstellungen Jugendlicher auf den Plattformen deutlich wird. Jan Keilhauer und Maren Würfel erweitern in ihrem Beitrag Jugendliche und Konvergenz 2.0 – Zur Bedeutung des Social Web bei der Aneignung von Inhalten der konvergenten Medienwelt diese Ergebnisse durch Befunde aus qualitativen Interviews. Das Autorenteam geht zwei Wegen der Aneignung von Inhalten im Social Web auf den Grund: der Aneignung über interpersonalkommunikative und produktiv-gestaltende Äußerungsformen einerseits und der Aneignung über Erscheinungsformen inhaltlicher Angeboteandererseits – seien es nutzergenerierte konvergente Angebote (Rezensionen, Persiflagen, Fan-Fiction, etc.), seien es alternative Zugänge zur massenmedialen Verwertungskette. Die Verwobenheit rezeptiver und produktiv-gestaltender Tätigkeiten bildet den Ausgangspunkt des Artikels Parodien als kritisch-reflexives Medienhandeln – Neue Partizipationskultur im medienkonvergenten Ringen um Bedeutung? Daniela Küllertz und Anja Hartung weisen im Rekursauf subversive medienbezogene Parodien (Yes Men, Front Deutscher Äpfel) auf die Potenzialeneuer medientechnischer Möglichkeiten für die Teilhabe an einer kritisch-reflexiven Partizipationskultur und die Förderung des kritischreflexiven Medienhandelns Jugendlicher hin. Eine spezifische Gruppe Jugendlicher stellen Gudrun Marci-Boehncke und Matthias Rath in ihrem Beitrag Jenseits von PISA – kompetent konvergent. Eine qualitative Studie zur konvergenten Handynutzung von Jugendlichen mit Migrationshintergrund in den Mittelpunkt. Mit dem Handy konzentrieren sie sich auf ein für Jugendliche höchst relevantes Medium, das vielfältig in das konvergente Medienensemble eingebunden und eng mit dem Internet verknüpft ist. Potenziale und Risiken des Handyumgangs ergründen sie im Kontext von Nutzungsmotiven und Sozialisationsbedingungen und diskutieren Konsequenzen für Bildungseinrichtungen. Auch Malin Hjorth und Tobias Olsson fokussieren auf spezifische Jugendliche. Sie greifen in ihrem Artikel For Mainstream and Alternative Activism: A Comparative Look at How Young Activists Navigate within the Converging Media World die These auf, dass sich unter den Bedingungen von Medienkonvergenz politische Partizipationsmöglichkeiten ändern. Sie untersuchen, wie politisch aktive Jugendliche Medien wahrnehmen und für politisches Handeln nutzen. Dabei beleuchten sie insbesondere die Rolle des Internets für die Ausbildung einer alternativen politischen Identität. Mit den nächsten fünf Beiträgen wird ein Perspektivenwechsel vollzogen. Die politische Dimensionvon Medienkonvergenz, in den Beiträgen von Küllertz/Hartung und Hjorth/Olsson bereits angesprochen, bildet den zweiten Fokus dieses Heftes. Eine grundlegende Diskussion des Konvergenzbegriffs mit seinen ökonomischen und politischen Verschränkungen liefert der Beitrag von Hans J. Kleinsteuber Convergence – Facts and Fictions about a Term and its Political Implications. Er geht davon aus, dass auch Divergenz als gleichrangiges Grundprinzip technologischer Entwicklung in der wissenschaftlichen Betrachtung nicht vernachlässigt werden darf. Manfred Mai rückt in seinem Artikel Traditionelle Prämissen und neue Medienwelt – die Antiquiertheit analogen Denkens im Digitalzeitalter die Grundlagen der Medienregulierung ins Zentrum. Mit Rückblick auf die Historie bundesdeutscher Medienregulierung fordert er eine wissenschaftliche Angemessenheitsprüfung im Hinblick auf aktuelle Entwicklungen. Er plädiert für eine länderübergreifende Mediengovernance, um den gesamtgesellschaftlichen Diskurs auch unter den technischen und ökonomischen Bedingungen von Medienkonvergenz zu gewährleisten. Inwieweit unter diesen Bedingungen ein gesamtgesellschaftlicher Diskurs und eine Teilhabean diesem gegeben ist, diskutieren Karsten Weber, Ricarda Drüeke, Oliver Langewitz und Michael Nagenborg in ihrem Beitrag Konvergente Medien – Integration oder Fragmentierung von Öffentlichkeit? In Anbetracht der aktuellen Ergebnisse der Nutzungsforschung diagnostizieren sie einen Trend zur Fragmentierung. Eine Governance-Perspektive zur Analyse der Entwicklungen des Jugendmedienschutzes schlagen Sven Jöckel und Catherina Dürrenberg in ihrem Artikel Vom Verbot zur Governance – Regulation in konvergenten Medienwelten für Kinder und Jugendliche vor. Sie kommen unter anderem zu dem Schluss, dass durch komplexe Angebotsstrukturen und konvergente Medieninhalte die Zahl der relevanten Akteure im Jugendmedienschutz gestiegen ist, die Hauptlast jedoch nach wie vor die Eltern tragen. Der Beitrag Ubiquitous Media – Ökonomische und technische Rahmung sozialer Handlungsmöglichkeiten wirft schließlich einen Blick in dieZukunft. Karsten Weber, Michael Nagenborg, Ricarda Drüeke und Oliver Langewitz gehen der Frage nach, wie mediale und gesellschaftliche Prozesse ineinandergreifen, wenn Medien nichtmehr Inhalte anbieten, sondern stattdessen das Leben der Menschen zunehmend – möglicherweise automatisiert – Medienstrukturen befüllt.

ASSESSMENT OF PARALLEL SIGNALING PATHWAYS IN UTERINE MYOCYTES STIMULATED WITH VARIOUS SMOOTH MUSCLE AGONISTS H.N. Aguilar, B.F. Mitchell 1 TRACTOGRAPHY: A NOVEL TECHNIQUE TO IMAGE FIBER TRACTS OF THE SPINAL CORD Fahad Alkherayf, Eve Tsai, Arturo Cardenas-Blanco, Alain Berthiaume, Brien Benoit, John Sinclair 1 MODULATION OF OSTEOCLASTOGENESIS IN INFLAMMATORY JOINT DISEASES H. Allard-Chamard, M. Durant, A.J. de Brum-Fernandes, G. Boire, S.V. Komarova, S.J. Dixon, S.M. Sims, R. Harison, M.F. Manolson 2 “THE RIGHT THING TO DO? A CRITICAL ANALYSIS OF PUBLIC HEALTH ETHICS, RIGHTS DISCOURSE, AND THE EXPANSION OF ANTIRETROVIRAL THERAPY (ART)” Berkhout, SG, Anderson, S, Tyndall, MW 2 COST-EFFECTIVENESS OF IMMEDIATE BASELINE COMPUTED TOMOGRAPHY VS. MAGNETIC RESONANCE IMAGING OF ACUTE ISCHEMIC STROKE IN ONTARIO PATIENTS WHO PRESENT WITH SYMPTOMS SUGGESTIVE OF STROKE KR Burton, G. Mery 3 CHITOSAN-MEDIATED FGF18 DELIVERY FOR ASSISTED BONE REPAIR A. Carli, M. Lavertu, C. Gao, A. Merzouki, M.D. Buschmann, J.E. Henderson, E.J.Harvey 3 ACTIVE PI3K-AKT SIGNALING PROMOTES THE METASTATIC POTENTIAL OF ASCITES-DERIVED EPITHELIAL OVARIAN CANCER CELLS Correa RJM, Ramos-Valdes Y, Bertrand M, Lanvin D, Préfontaine M, Sugimoto AK, Lewis JD, Shepherd TG, DiMattia GE 4 MECHANISMS OF K65R, D67N, K103N, V106M AND M184V RESISTANCE DEVELOPMENT IN SUBTYPE-B AND C HIV-1 Dimitrios Coutsinos, Cedric F. Invernizzi, Daniela Moisi, Maureen Oliveira, Hongtao Xu, Bluma G. Brenner, Mark A. Wainberg 4 A MODEL TO DETERMINE FACTORS INVOLVED IN THE INDUCTION OF AN IN VIVO CTL RESPONSE Dissanayake D, Ohashi PS 5 P63 ANTAGONIZES P53 TO PROMOTE THE SURVIVAL OF EMBRYONIC NEURAL PRECURSOR CELLS Sagar B. Dugani, Annie Paquin, Masashi Fujitani, David R. Kaplan, Freda D. Miller 5 SPINAL LOCOMOTOR NETWORK MODULATION BY ENDOGENOUS SEROTONIN IN THE ISOLATED NEONATAL MOUSE SPINAL CORD Dunbar MJ, Whelan PJ 6 THE TUMOR PROMOTING AND REPRESSING EFFECTS OF INTEGRIN-LINKED KINASE ARE DIFFERENTIATED BY JNK1 IN HUMAN CANCER CELLS Adam David Durbin, Gregory Edward Hannigan, David Malkin 6 INCREASED EXCITATION IN MICE OVER-EXPRESSING NEUROLIGIN-1 IS ASSOCIATED WITH IMPAIRED LONG-TERM POTENTIATION AND LEARNING AND MEMORY Brennan D Eadie, Timal Kannangara, Regina Dalhaus, Rochelle M Hines, Yu-Tian Wang, Alaa El-Husseini, Brian R Christie 7 A NOVEL ROLE FOR CDK5/P35 IN MEDULLOBLASTOMA FORMATION Friesen AN, Shin J, Law V, Lee YS, Mckinnon P, Lee KY 7 ALTERED PSYCHOSOCIAL BEHAVIOUR AND STRESS RESPONSE FOLLOWING ‘MINOR’ STROKE IN THE RAT Krista Hewlett, Meighan Kelly, Dale Corbett 8 TUMOUR PATHOLOGY PREDICTS MICROSATELLITE INSTABILITY IN COLORECTAL CANCER AJ Hyde, D Fontaine, S Stuckless, RC Green, A Pollett, M Simms, P Parfrey, HB Younghusband 8 PROTEINASE-ACTIVATED RECEPTOR-2 (PAR2) IS A POTENTIAL TARGET FOR THE ANTI-INFLAMMATORY EFFECTS OF INSULIN Eric Hyun, Rithwick Ramachandran, Nicolas Cenac, Steeve Houle, Amit Saxena, Roland S. Liblau, Morley Hollenberg, Nathalie Vergnolle 9 CHEMOSENSITIVE PROPERTIES OF THE VENTRAL MEDULLA IN VITRO Kalf Daniel J, Wilson Richard JA 9 NOVEL DOPAMINE RECEPTOR-N TYPE CALCIUM CHANNEL INTERACTIONS: POTENTIAL THERAPEUTIC TARGETS FOR DISORDERS ASSOCIATED WITH ABERRANT DOPAMINERGIC SIGNALLING Alexandra E. Kisilevsky, Sean J. Mulligan, Christophe Altier, Mircea C. Iftinca, Diego Varela, Chao Tai, Lina Chen, Shahid Hameed, Jawed Hamid, Brian A. MacVicar, Gerald W. Zamponi 10 TRUNCATION OF THE C-TERMINAL DOMAIN OF CONNEXIN43 INCREASES INFARCT VOLUME DURING STROKE Kozoriz MG, Bechberger JF, Bechberger GR, Suen MWH, Moreno AP, Maass K, Willecke K, Naus CC 10 EVALUATION OF THE DELIVERABILITY AND TOLERABILITY OF INTENSIVE WEEKLY DOUBLET ADJUVANT CHEMOTHERAPY IN NON SMALL CELL LUNG CANCER M. Sara Kuruvilla, Lorraine Martelli-Reid, J. R. Goffin, A. Arnold, Peter M. Ellis 11 A POLICY-ORIENTED SYSTEMATIC REVIEW OF THE SAFETY AND EFFICACY OF ENDOSCOPIC THERAPIES FOR THE TREATMENT OF BARRETT’S ESOPHAGUS Lau D, Menon D, Stafinski T, Topfer LA, Walker J 11 THE SRC-LIKE ADAPTOR PROTEIN, SLAP, PLAYS A ROLE IN MONOCYTE-DERIVED DENDRITIC CELL MATURATION Larissa Liontos, L Dragone, A Weiss, C J McGlade 12 SWEET PEE: A NEW MOUSE MODEL FOR GLOMERULOCYSTIC KIDNEY DISEASE AND GLUCOSURIA J Ly, J Rossant, L Oxborne, C McKerlie, A Flenniken, S Quaggin 12 CARDIOGENIC SHOCK IN ASPHYXIATED NEONATE PIGLETS: IS COMBINATION INOTROPE THERAPY BETTER THAN HIGH-DOSE DOPAMINE? N. Manouchehri, P.-Y. Cheung, C. Joynt, T. Churchill, D. Bigam 13 THE RELATIONSHIP BETWEEN FLOW-MEDIATED DILATION, HYPEREMIC SHEAR STRESS, AND VARIOUS ANTHROPOMETRIC INDICES OF OBESITY Martin BJ, Title LM, Verma S, Charbonneau F, Buithieu J, Lonn EM, Anderson TJ 13 RAPID LOCALIZATION OF NEUTROPHILS TO SITES OF CELL DEATH BY MAC1-DEPENDENT ADHESION AND INTRAVASCULAR CRAWLING McDonald B, Menezes GB, Kubes P 14 THE ROLE OF SHIP-1 IN CEACAM1-MEDIATED HOST RESPONSES TO NEISSERIA GONORRHOEAE INFECTION Gordon G McSheffrey, S D Gray-Owen 14 USING VOLTAGE-SENSITIVE DYES TO RECORD BRAIN ACTIVITY IN NATURALLY MOVING MICE McVea DA, Mohajerani MH, Fingas M, Murphy TH 15 POTENTIAL MECHANICAL INFLUENCE IN MICROVASCULAR PATHOLOGY IN THE ACL DEFICIENT RABBIT KNEE Daniel Miller 15 OSTEOBLAST MECHANOSENSITIVITY: THE ROLE OF HYDROSTATIC PRESSURE Kenneth A. Myers, Timothy Douglas, Ricarda Hess, Justin Parreno, Jerome B. Rattner, Dieter Scharnweber, Nigel G. Shrive, David A. Hart 16 ENDOTHELIAL PROGENITOR CELLS FOR HEALING AND ANGIOGENESIS IN A SEGMENTAL BONE DEFECT MODEL: A COMPARISON WITH MESENCHYMAL STEM CELLS Nauth A, Li R, Schemitsch EH 16 DELAY OF DNA METHYLATION IN PERINATAL MALE GERM CELLS IN THE ABSENCE OF DNMT3L RESULTING IN INFERTILITY Kirsten Niles, Sophie La Salle, Christopher Oakes, Jacquetta Trasler 17 INVESTIGATING CRMP4 FUNCTION IN CNS NERVE REGENERATION S. Ong Tone, S. Kanagal, A. Wilson, Y.Z. Alabed, A. Di Polo, A.E. Fournier 17 A NOVEL, DNA DAMAGE-DEPENDENT REGULATORY PATHWAY FOR AKT IN VIVO Andrew J. Perrin, W. Brent Derry 18 CHOP AS A TARGET FOR PRESERVATION OF TRANSPLANTED ISLET GRAFT MASS Potter K, Dai L, Verchere CB 18 TREATMENT OF ACHILLES TENDINOPATHY R Ram, C Patel, D Wiseman, W Meeuwisse, JP Wiley 19 PLACENTAL LACTOGEN FUNCTION IN POST-IMPLANTATION MURINE PREGNANCY Saara M. Rawn, James C. Cross 19 DECODING NEURAL SIGNALS FROM MULTIELECTRODE ARRAYS IN THE PRIMATE DORSOLATERAL PREFRONTAL CORTEX Sachs A.J, Pieper F, Martinez-Trujillo J.C. 20 THE ROLE OF TRANSFORMING GROWTH FACTOR ALPHA IN A MOUSE MODEL OF OSTEOARTHRITIS Usmani S.E, Appleton C.T.G., Welch I.D, Beier F. 20 SKIN-DERIVED STEM CELLS ACT AS FUNCTIONAL SCHWANN CELLS WHEN TRANSPLANTED INTO LESIONED PERIPHERAL NERVE Sarah K. Walsh, Rajiv Midha 21 TLR4 MEDIATES SUSCEPTIBILITY TO STREPTOZOTOCIN-INDUCED DIABETES C Westwell-Roper, G Soukhatcheva, MJH Hutton, JP Dutz, CB Verchere 21 A FUSION OF GMCSF AND IL-21 (GIFT-21) POTENTLY INDUCES INFLAMMATION AND APOPTOSIS THROUGH SIGNALS DOWNSTREAM OF THE IL-21R ALPHA CHAIN Patrick Williams, Shala Yuan, Jessica Cuerquis, Elena Birman, Kathy Ann Forner, Jacques Galipeau 22

e4217123This article aims to discuss the issue of diversity present in school institutions and the need for work aimed at valuing the masses excluded by society, emphasizing the question of the rights of black people and women. Based on the need for work to overcome racism and sexism, we highlight the relevance of continuing training for beginning teachers, as they leave the universities and face the reality of schools, experiencing the “shock of the real”. Our proposal is for teachers to be prepared for a more inclusive performance, developing a critical and accurate look at the role they play in mediating social relations within the classroom, presenting a way of working based on respect for Human Rights, in dialogue intercultural and in valuing the uniqueness of each person. With this intent, the present research, of bibliographic and analytical nature, permeates the historical-social questions of black people and women in society, going through the difficulties of the teaching work at the beginning of their careers, mainly in the domain of content and organization/lesson planning, emphasizing the need for actions aimed at the inclusion of all, challenges that are addressed by authors who deal with the reality of the beginning teacher and the training needs at the beginning of his career. In short, the purpose of this paper is to contribute to research on the themes of human diversity, aiming to problematize the work of teachers and beginners through the prism of human rights.ResumoO presente artigo visa discutir a questão da diversidade presente nas instituições escolares e a necessidade de um trabalho voltado à valorização das massas excluídas pela sociedade, dando ênfase à questão dos direitos dos negros e das mulheres. Partindo da necessidade de um trabalho de superação do racismo, do machismo e do sexismo, destacamos a relevância de formações continuadas para os professores iniciantes, porquanto ao saírem das universidades se deparam com a realidade das escolas, passando pelo “choque do real”. Nossa proposta é que os professores sejam preparados para uma atuação mais inclusiva, desenvolvendo um olhar crítico e acurado acerca do papel que representam na mediação das relações sociais dentro de sala de aula, apresentando uma forma de trabalho pautada no respeito aos Direitos Humanos, no diálogo intercultural e na valorização da singularidade de cada pessoa. Com este intento, a presente pesquisa, de cunho bibliográfico e analítica, permeia as questões histórico-sociais dos negros e das mulheres em sociedade, perpassando pelas dificuldades do trabalho docente em início de carreira, principalmente em se tratando do domínio do conteúdo e da organização/planejamento das aulas, enfatizando a necessidade de ações voltadas à inclusão de todos, desafios estes que são abordados por autores que tratam da realidade do professor iniciante e das necessidades formativas neste início de carreira. Em suma, o intuito do presente trabalho é contribuir para as pesquisas referentes às temáticas da diversidade humana, visando problematizar o trabalho docente e do professor iniciante pelo prisma dos Direitos Humanos.Palavras-chave: Professor iniciante, Necessidade formativa, Diversidade.Keywords: Beginning teacher, Training need, Diversity.ReferencesASSEMBLEIA GERAL DAS NAÇÕES UNIDAS. Declaração Universal dos Direitos Humanos. Paris. 10 dez. 1948. 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<strong>ABSTRACT</strong> The diversity of mycorrhizal fungi in the rhizosphere of the carob tree (<em>Ceratonia siliqua</em>) was studied in five regions of Morocco: Taroudant, Kh&eacute;nifra, Afourar, Nador and Ksiba. Microscopic examination of the carob tree soil, collected from the studied areas, revealed the presence of 31 AM fungal species belonging to six genera <em>Glomus</em> (16 species),<em> Acaulospora</em> (7 species), <em>Scutellospora </em>(4 species), <em>Gigaspora</em> (2 species), <em>Entrophospora</em> and <em>Pacispora</em> (one species each)<em>. </em>The genus <em>Glomus</em> is the most abundant with a distribution percentage of 93%. Species richness varies between 13 and 18 species. All the encountered species were morphologically characterized basing on: shape, color, average size of the spore and its wall, spore surface and size of the hyphae. The diversity of AM fungi in different ecological studied zones varies from one site to another, it is higher in Taroudant site, the Shannon-Wiener index H &#39; is in the order of 2.78 and the index of Margalef IM 3.6. Furthermore, the similarity index of Jaccard shows a strong similarity between the Taroudant site and that of Afourar. <strong>Keywords: </strong><em>Ceratonia siliqua, </em>endomycorrhizae, Carob tree, Morocco, Fungi. <strong>REFERENCES </strong> &nbsp; Abbas Y., Ducousso M., Abourough M., Azcon R. and Duponnois R., 2006. Diversity of arbuscular mycorrhizal fungi in Tetraclinis articulata (Vahl) Masters woodlands in Morocco. Ann For Sci., 63: 285&ndash;291. Ait Aguil F., 2005. Contribution &agrave; l&rsquo;&eacute;tude de la biodiversit&eacute; de la flore fongique des for&ecirc;ts marocaines : cas des Basidiomyc&egrave;tes du Rif Occidental et des Gast&eacute;romyc&egrave;tes de la Mamora. Th&egrave;se de Doctorat, Univ. Ibn Tofail, Fac. Sci. K&eacute;nitra, 139 p. 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e4912046This scoping exploratory review was aimed at analyzing the challenges that the so-called post-truth world represents for teaching in Ibero-Latin American higher education. With the increased access to online information media and social networks, netizens are increasingly exposed and may be more vulnerable to false or misleading information that seeks to generate action from emotions rather than reason (GOSWAMI, 2017, Chronicle of Higher Education). The reference search was carried out in the databases of SciELO and La Referencia, from which 26 titles out of 196 were selected. Combinations of terms such as social media, post-truth, fake news, fact-checking, education, higher education, university, teaching, critical thinking, and freedom of expression were used, with the Boolean “Y” connector. The analysis of the references resulted in six thematic categories: main concepts; realms of fake news; news verification initiatives and methods; theoretical analysis and its relationship with education; studies on the factors, perception and credibility of fake news; and addressing misinformation in higher education. The discussion presents the draft of a proposed pedagogical model to be used in higher education and to address misinformation. Includes: critical thinking habits, democratic dialogue, intellectual skepticism, research skills, use of reliable sources of information, and analysis from multiple perspectives.ResumoEsta revisão exploratória de escopo teve como objetivo analisar os desafios que o chamado mundo pós-verdade representa para o ensino na educação superior ibero-americana. Com o aumento do acesso às mídias de informação online e redes sociais, os internautas estão cada vez mais expostos e podem ficar mais vulneráveis a informações falsas ou enganosas que buscam gerar ações a partir de emoções ao invés da razão (GOSWAMI, 2017, Chronicle of Higher Education). A busca das referências foi realizada nas bases de dados SciELO e La Referencia, das quais foram selecionados 26 títulos em 196. Combinações de termos como mídia social, pós-verdade, notícias falsas, checagem de fatos, educação, ensino superior, universidade, ensino, pensamento crítico e liberdade de expressão foram usadas, com o conector booleano “Y”. A análise das referências resultou em seis categorias temáticas: conceitos principais; escopos de notícias falsas; iniciativas e métodos de verificação de notícias; análise teórica e sua relação com a educação; estudos sobre os fatores, percepção e credibilidade das notícias falsas; e aproximação a desinformação no ensino superior. A discussão apresenta o esboço de uma proposta de modelo pedagógico para ser usado no ensino superior e para lidar com a desinformação. Inclui: hábitos de pensamento crítico, diálogo democrático, ceticismo intelectual, habilidades de pesquisa, uso de fontes confiáveis de informação e análise de múltiplas perspectivas.ResumenEsta revisión exploratoria de alcance tuvo como fin analizar los desafíos que para la enseñanza en la educación superior iberoamericana representa lo que se denomina el mundo posfactual (post-truth). Con el incrementado acceso a medios de información en línea y las redes sociales, los cibernautas están cada vez más expuestos y pueden ser más vulnerables a información falsa o engañosa que busca generar acción a partir de las emociones antes que la razón (GOSWAMI, 2017, Chronicle of Higher Education). La búsqueda de referencias se efectuó en las bases de datos de SciELO y La Referencia, de la cual se seleccionaron 26 títulos de 196. Se usaron combinaciones de términos como redes sociales, posverdad, noticias falsas, verificación de hechos, educación, educación superior, universidad, enseñanza, pensamiento crítico y libertad de expresión, con el conector booleano “Y”. El análisis de las referencias dio como resultado seis categorías temáticas: conceptos principales; ámbitos de las noticias falsas; iniciativas y métodos de verificación de noticias; análisis teóricos y su relación con la educación; estudios sobre factores, percepción y credibilidad de las noticias falsas; y abordaje de la desinformación en la educación superior. En la discusión se presenta el borrador de un modelo pedagógico propuesto para ser utilizado en la educación superior y abordar la desinformación. 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Aim: The research aimed to investigate the antimalarial activity of the plant Daniellia oliveri (Rolfe) Hutch. &amp; Dalziel (Caesalpiniaceae) bark methanol extract.&#x0D; Methodology: The bark dried, powdered bark of Daniellia oliveri was extracted with n-hexane followed by methanol. methanol extract of Daniellia oliveri was tested for antimalarial (curative test) by being tested against Plasmodium berghei in mice at doses of 100, 400, and 600 mg/kg. An acute toxicity study was carried out according to OECD 423 protocol, and phytochemical screening using standard protocols. HPLC-MS was also conducted using Agilent InfinityLab LC/MSD with Eclipse plus C18 5.0 µm 4.6 mm x 250 mm column and data were processed with Agilent Openlab Chemstation software.&#x0D; Results: Preliminary phytochemical screening of the extract revealed the presence of flavonoids, tannins, alkaloids, phenolics, and terpenoids. The methanol extract was found to be safe at doses up to 5000 mg/kg body weight (acute lethal dose, LD50) in mice. There was a significant difference in activity between the non-treated, standard, and extract dosage groups at (p&lt;0.05). The HPLC-MS analysis showed the presence of 56 compounds. Daniella oliveri bark methanol extract has High activity against Plasmodium berghei, an 81.1% reduction in parasitemia at a dose of 600mg/kg body weight, and a Mean survival time of excess 5.&#x0D; Conclusion: Daniellia oliveri is a rich source of phytochemicals and a potential source of antimalarial agent(s).

Aims: The aim of this study is to evaluate the content of phenolic compounds, antioxidant and 15-lipoxygenase inhibition effects of methanolic extract and its fractions of Daniellia. oliveri stem bark.&#x0D; Place and Duration of Study: The work was carried out in the Department of Traditional Pharmacopoeia and Pharmacy (MEPHATRA / PH) of the Institute for Research in Health Sciences (IRSS) and LABIOCA from Université Joseph KI-ZERBO in Ouagadougou between February 2018 and June 2019&#x0D; Methodology: The phytochemical screening and phenolic content were determined by the methods described in the literature. Antioxidant activity was determined by DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,20-azinobis 3-ethylbenzoline-6-sulphonate), FRAP (ferric reducing antioxidant power), and lipid peroxidation (LPO). The anti-inflammatory activities were measured on the ability of the extract to inhibit the activity of enzymes such as 15-lipoxygenase&#x0D; Results: Phytochemical screening revealed the presence of flavonoids, tannins, saponins, anthocyanosides, triterpenes and sterols. The extract and its fractions showed a good content of phenolic compounds with values ranging from 773.97 ± 22.91 to 505.51 mg EAG / g for total polyphenols; from 24.38 ± 0.34 to 12.04 ± 0.08 mg EQ / g in total flavonoids, 311.65 ± 6.70 to 221 ± 0.52 mg EC / g in condensed tannins; 681.81 ± 3.97 to 421.29 ± 8.73 mg EUA / g in total triterpenes and from 280.29 ± 21.72 to 222.04 ± 20.99 mg EC / g for total sterols. The methanol fraction showed the best antioxidant activity as well as the best inhibitory effect on 15-lipoxygenase activity.&#x0D; Conclusion: These results showed that Daniellia. oliveri possessed an antioxidant power, an inhibitory effect of 15 lipoxygenase. Daniellia oliveri could be used in the management of inflammatory pathologies and oxidative stress.

Aims: The aim of this study is to evaluate the content of phenolic compounds, antioxidant and 15-lipoxygenase inhibition effects of methanolic extract and its fractions of Daniellia. oliveri stem bark.&#x0D; Place and Duration of Study: The work was carried out in the Department of Traditional Pharmacopoeia and Pharmacy (MEPHATRA / PH) of the Institute for Research in Health Sciences (IRSS) and LABIOCA from Université Joseph KI-ZERBO in Ouagadougou between February 2018 and June 2019&#x0D; Methodology: The phytochemical screening and phenolic content were determined by the methods described in the literature. Antioxidant activity was determined by DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,20-azinobis 3-ethylbenzoline-6-sulphonate), FRAP (ferric reducing antioxidant power), and lipid peroxidation (LPO). The anti-inflammatory activities were measured on the ability of the extract to inhibit the activity of enzymes such as 15-lipoxygenase&#x0D; Results: Phytochemical screening revealed the presence of flavonoids, tannins, saponins, anthocyanosides, triterpenes and sterols. The extract and its fractions showed a good content of phenolic compounds with values ranging from 773.97 ± 22.91 to 505.51 mg EAG / g for total polyphenols; from 24.38 ± 0.34 to 12.04 ± 0.08 mg EQ / g in total flavonoids, 311.65 ± 6.70 to 221 ± 0.52 mg EC / g in condensed tannins; 681.81 ± 3.97 to 421.29 ± 8.73 mg EUA / g in total triterpenes and from 280.29 ± 21.72 to 222.04 ± 20.99 mg EC / g for total sterols. The methanol fraction showed the best antioxidant activity as well as the best inhibitory effect on 15-lipoxygenase activity.&#x0D; Conclusion: These results showed that Daniellia. oliveri possessed an antioxidant power, an inhibitory effect of 15 lipoxygenase. Daniellia oliveri could be used in the management of inflammatory pathologies and oxidative stress.

Objectives: Daniellia oliveri Rolfe is a well-known plant of Fabaceae family whose previous phytochemical and pharmacological studies led to the identification of triterpenoid, phenol, anthraquinone oxalate with antioxidant, antibacterial and antifungal activities. This study aimed to investigate chemical constituents and evaluate the antimicrobial potency of the root of D. oliveri. Methods: The methanol extract of the root barks of D. oliveri was subjected to silica gel chromatographic separation. The structures of the isolated compounds (1-9) were determined by analyzing their spectrometric and spectroscopic spectra. Single-crystal-Xray analysis was used to establish the absolute skeletal structure of compound 1. Crude extract, fractions and compounds were investigated against four bacteria vis Pseudomonas aeruginosa 27853, Escherichia coli 5, Staphylococcus aureus 25923 and Streptococcus sp . 9619 and, two yeast vis Candida albicans14053 and Candida tropicalis 018 using broth microdilution method. Results: The phytochemical prospection of the methanol extract of D. oliveri allowed the isolation of a naturally crystallized diterpenoid type furolabdane: polyalthic acid 1, as well as eight amorphous compounds (2-9). Among the tested samples, the crude extract, fractions and compounds selectively showed inhibitory effects against the tested microorganisms with MIC values ranging from 4 to 1024 μg/mL. Fraction D1 and compounds 1, 4, 7, 8 and 9 exhibited the broadest antimicrobial effects among fractions and compounds while D5 and compound 1 showed the best activity with MIC values of 16 and 4 μg/mL respectively against E. coli which appeared to be the most sensitive strain . Conclusion: Polyaltic acid (1) showed the best activity with significant MIC value of 4 μg/mL identical to that of ceftazidine against E. coli. The MIC values of the active compounds 1, 4 and 7 are comparable to those of ceftazidime. Then, these compounds from natural origin, could serve as markers in the standardization of Daniellia plant as phytomedicine.

Background: Mitochondrial-mediated cell death begins with opening of mitochondrial membrane permeability transition (mPT) pore and medicinal plants contain phytochemicals that modulate the mPT pore.&#x0D; Hypothesis and Purpose: We investigated the modulatory effects of crude methanol extract of Daniellia oliveri leaves (CMDO) on mPT pore in vitro.&#x0D; Study Design and Methods: Phytochemical screening and antioxidant activities of crude methanol extract of Daniellia oliveri leaves (CMDO) were evaluated according to standard procedures. CMDO was partitioned into chloroform fraction (CFDO), ethyl acetate fraction (EFDO) and methanol fraction (MFDO) by Vacuum liquid chromatography (VLC). Effects of CMDO, CFDO, EFDO and MFDO on mPT pore were assessed by spectrophotometry. Effects of the most potent fraction on mitochondrial ATPase, Fe-induced lipid peroxidation and cytochrome c release were assessed by spectrophotometry. CMDO was subjected to GC-MS analysis to identify the bioactive compounds present.&#x0D; Results: CMDO contains phytochemicals and showed appreciable total flavonoid content (0.483±0.02 QE mg/100g), total phenolic content (0.886±0.12 GAE mg/100g), total antioxidant capacity (0.039±0.001 AE mg/100 g), ferric antioxidant reducing power (IC50=350 µg/ml) and 2, 2-diphenyl-1 picrylhydrazyl (DPPH) radical scavenging activity (IC50=166 µg/ml). The maximum induction of mPT pore opening in the absence and presence of calcium, respectively, were as follows: CMDO (10.11 folds, 5.18 folds), CFDO (19.9 folds, 16.3 folds), EFDO (7.5 folds, 23.2 folds), MFDO (22.2 folds, 31.3 folds). The most potent mPT pore-opening fraction (MFDO) enhanced mitochondrial ATPase activity, inhibited Fe-induced lipid peroxidation and caused cytochrome c release. GC-MS analysis of CMDO revealed the presence of bioactive compounds including methyl propanamide, Dibutyl phthalate, saturated and unsaturated fatty acids.&#x0D; Conclusion: Methanol fraction (MFDO) of CMDO most potently induced mPT pore opening via enhancement of mitochondrial ATPase activity, which was substantiated by the release of cytochrome c (in vitro). This includes MFDO as a candidate pharmacologic remedy for diseases associated with insufficient apoptosis.

This study evaluated the impact of Daniellia oliveri leaf extract (DOLE) on hematological parameters and thermoregulation in growing bucks. Forty-five rabbits were randomly assigned to three treatment groups (15 per group) with balanced initial body weights (average 0.27 kg). The treatments included a control diet (T1), the control diet plus 5 ml DOLE/kg feed (T2), and the control diet plus 10 ml DOLE/kg feed (T3), in a completely randomized design. Blood samples were analyzed using an Abacus Ross hematology analyzer at the end of the trial. Rectal temperature was significantly higher in T1, while T2 and T3 showed better thermoregulation. Hematological results showed improved values of hemoglobin (Hb), red blood cells (RBC), white blood cells (WBC), and mean corpuscular hemoglobin concentration (MCHC) in the order T3 &gt; T2 &gt; T1. Similar trends were observed for packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), lymphocytes, monocytes, and platelets, with T1 showing the lowest values. Eosinophils and neutrophils were highest in T3, while the neutrophil/lymphocyte ratio was unaffected by treatment. Heart rate (243.50–249.60 bpm) and respiratory rate (54.25–55.26 cycles/min) did not differ significantly among groups. Overall, DOLE supplementation enhanced blood profiles and supported body temperature regulation, with 10 ml DOLE/kg diet identified as the most effective dosage for improving physiological health in rabbits.

This study aimed to provide data on the subacute toxicity and fetotoxicity of aqueous and hydroethanolic extracts of Daniellia oliveri (Rolfe) Hutch. &amp;amp; Dalziel, Anacardium occidentale L., Diospyros mespiliformis Hochst. ex A. DC., Khaya senegalensis (Desv.) A. Juss., Ocimum gratissimum L., Vernonia amygdalina Delile, Pterocarpus erinaceus Poir., and Manihot esculenta Crantz used in the treatment of diarrheal diseases in Benin. For subacute toxicity, each male and female Wistar rat received by esophageal gavage a maximum of 1000 mg/kg over 28 days following the Organization for Economic Co-operation and Development (OECD) Guideline No. 407. Bodyweight changes, biochemical and hematological parameters were assessed. The fetotoxicity of the extracts was evaluated on Dutch Blue hen eggs at 100 mg/kg and 300 mg/kg. The hatching rate, biochemical and hematological constants were subsequently determined. The subacute toxicity data did not indicate any mortality or signs of toxicity. Also, no significant difference in the bodyweight of the rats and the hematological parameters was noted. Concerning fetotoxicity, a low hatching rate (varying from 20% to 50%) was observed in the batches treated with the extracts at 300mg/kg compared to the rate obtained in the negative control batch (80%). The batches that received the hydroethanolic extracts of Vernonia amygdalina and Manihot esculenta at the tested doses had a hatching rate of 0%. When looking at hematological parameters, no significant difference was noted for all batches. However, an increase in the Aspartate Amino-Transferase (ASAT) values was noted in the batches that received the hydroethanolic extract of Khaya senegalensis and the aqueous extract of Diospyros mespiliformis at 100 and 300 mg/kg. These results explicitly show that the hydroethanolic extracts of Manihot esculenta and Vernonia amygdalina are fetotoxic at the tested doses.