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Iryani, Nanda, Afifah Dwi Ramadhani, and Queenta Paradissa Ramadhani. "Analisis Performansi Data Plane Development Kit Terhadap Open Virtual Switch pada Jaringan Virtual." JTERA (Jurnal Teknologi Rekayasa) 6, no. 1 (2021): 93. http://dx.doi.org/10.31544/jtera.v6.i1.2021.93-100.
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Sadarang, Rimawati Aulia Insani, A. Syamsiah Adha, Sukfitriyanti Syahrir, Abd Majid HR.Lagu, Muh Fajar Pahrir, and A. Suci Awaliyah Ishak. "PEMANFAATAN SISTEM OPEN DATA KIT SEBAGAI MEDIA PENGUMPULAN DATA." Journal of Information System, Applied, Management, Accounting and Research 5, no. 1 (2021): 94. http://dx.doi.org/10.52362/jisamar.v5i1.344.
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Perkembangan teknologi komunikasi dan informasi yang masif memberi tuntutan pelaksanaan penelitian yang lebih cepat, namun tetap efektif dan efisien. Pengumpulan hingga analisis data merupakan rangkaian proses penelitian dengan alokasi waktu dan dana yang terbesar. Penelitian ini bertujuan untuk memberikan alternatif pemanfaatan produk teknologi agar proses pengumpulan hingga analisis data dapat berlangsung efektif dan efisien. Pada penelitian ini, sistem Open Data Kit (ODK) dikembangkan sebagai media pengumpulan data. Penggunaan sistem ini dapat memberikan efisiensi pembiayaan pengadaan instrumen penelitian/ kuesioner kertas, dapat meniadakan proses penginputan, kompilasi dan pre-prosesing data sehingga proses analisis dapat berlangsung lebih cepat. Pemanfaatan sistem ODK akan sangat membantu pelaksanaan penelitian agar efektif dan efisien karena penggunaan yang sederhana, dapat dikembangkan sesuai dengan kebutuhan penelitian dan tidak membutuhkan keterampilan khusus untuk dapat mengoperasikannya
 The massive development of communication and information technology demands a faster, yet effective and efficient research implementation. Data collection to analysis is a series of research processes with the largest allocation of time and funds. This study aims to provide an alternative use of technology products so that the process of collecting and analyzing data can be effective and efficient. In this study, the Open Data Kit (ODK) system was developed as a data collection medium. The use of this system can provide cost efficiency in the procurement of research instruments / paper questionnaires, can eliminate the process of inputting, compiling and pre-processing data so that the analysis process can take place more quickly. The use of the ODK system will greatly assist the implementation of research to be effective and efficient because of its simple use, it can be developed according to research needs and does not require special skills to be able to operate it.
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Park, Joonsuu, and KeeHyun Park. "A Dynamic Plane Prediction Method Using the Extended Frame in Smart Dust IoT Environments." Sensors 20, no. 5 (2020): 1364. http://dx.doi.org/10.3390/s20051364.
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Internet of Things (IoT) technologies are undeniably already all around us, as we stand at the cusp of the next generation of IoT technologies. Indeed, the next-generation of IoT technologies are evolving before IoT technologies have been fully adopted, and smart dust IoT technology is one such example. The concept of smart dust IoT technology, which features very small devices with low computing power, is a revolutionary and innovative concept that enables many things that were previously unimaginable, but at the same time creates unresolved problems. One of the biggest problems is the bottlenecks in data transmission that can be caused by this large number of devices. The bottleneck problem was solved with the Dual Plane Development Kit (DPDK) architecture. However, the DPDK solution created an unexpected new problem, which is called the mixed packet problem. The mixed packet problem, which occurs when a large number of data packets and control packets mix and change at a rapid rate, can slow a system significantly. In this paper, we propose a dynamic partitioning algorithm that solves the mixed packet problem by physically separating the planes and using a learning algorithm to determine the ratio of separated planes. In addition, we propose a training data model eXtended Permuted Frame (XPF) that innovatively increases the number of training data to reflect the packet characteristics of the system. By solving the mixed packet problem in this way, it was found that the proposed dynamic partitioning algorithm performed about 72% better than the general DPDK environment, and 88% closer to the ideal environment.
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Yoshida, H., T. Kunisada, M. Kusakabe, S. Nishikawa, and S. I. Nishikawa. "Distinct stages of melanocyte differentiation revealed by anlaysis of nonuniform pigmentation patterns." Development 122, no. 4 (1996): 1207–14. http://dx.doi.org/10.1242/dev.122.4.1207.
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The injection of an antagonistic anti-murine c-kit monoclonal antibody ACK2 during mouse embryonic development produced three distinctive pigmentation patterns on the coat of the offspring. Pattern 1 consisted of pigmentation in craniofacial and caudal regions and was induced by an ACK2 injection between 9.5 and 11.5 days post coitum (dpc). In pattern 2, the entire coat was unpigmented and was induced by the injection at around 13.0 dpc. Pattern 3 consisted of pigmented patches spreading ventrolaterally from the dorsoanterior trunk regions towards the anterior and posterior directions and it was induced by ACK2 administered at 14.5-15.0 dpc. We investigated the embryological basis of these nonuniform pigmentation patterns to elucidate the process of melanoblast differentiation between lineage commitment and colonization into developing hair follicles. The results showed the following. (1) Melanocyte differentiation at the embryonic stage from 10.5 to 12.5 dpc progresses in a spatially nonuniform fashion, being faster in the craniofacial and caudal regions than in the trunk; pattern 1 reflects this. (2) Melanoblasts are activated to proliferate synchronously upon entering into the epidermis; pattern 2 correlates with this process. (3) c-kit functions as a survival signal for proliferating melanoblasts in the epidermis. (4) The melanoblasts that enter developing hair follicles can survive without a c-kit signal; pattern 3 essentially represents the hair follicles colonized by these cells. Analysis of the melanoblast distribution of ls/ls embryos that bear a loss-of-function mutation in the endothelin 3 gene suggested that endothelin 3 is required for early melanoblast differentiation before entering into the epidermis, whereas proliferation in the epidermis takes place without this molecule. Based on these data, we propose 4 distinct steps of embryonic melanocyte differentiation: (1) migration in the dermis, which requires both c-kit and endothelin 3; (2) a state before epidermal entry that is resistant to anti-c-kit mAb; (3) cell proliferation after entering the epidermal layer, which requires c-kit and endothelin receptor B but not endothelin 3 and (4) integration into developing hair follicles, which renders melanoblasts resistant to anti-c-kit mAb. Thus, melanoblast differentiation proceeds by alternately repeating c-kit -dependent and c-kit-independent stages and c-kit functions as a survival factor for the proliferating melanoblasts.
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Hyeon Kim, Ki, Dongkyun Kim, Yong Hwan Kim, and Joobum Kim. "Performance measurement using dpdk in software-defined local and wide area networks." International Journal of Engineering & Technology 7, no. 2.12 (2018): 119. http://dx.doi.org/10.14419/ijet.v7i2.12.11105.
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Background/Objectives: For data center-based enterprises, the use of data traffic continues to increase. As a result, the increasingly efficient processing of increasing data traffic is becoming a major issue. Effective processing of traffic can be performed through the addition of physical network equipment, but this requires considerable costs.Methods/Statistical analysis: To solve this problem, researches on server virtualization and network virtualization technology are being actively conducted. However, while network virtualization is a cost-effective solution, open-source virtual switches used in network virtualization technologies have the performance penalty because they handle packets at the kernel of server's operating system. As a result, the Intel has developed the Data Plane Development Kit (DPDK) technology to address the performance degradation of the operating system.Findings: In this paper, we propose the DPDK performance test environment based on Open Virtual Switch (OVS) to verify the stability and performance of the DPDK-oriented virtualization technology, in association with a new KREONET-S project which aims tothe softwarization of the Korea Research Environment Open Network (KREONET) infrastructure.Improvements/Applications: We perform conducted experiments on Software-Defined Local Area Network (LAN) and Wide Area Network (WAN) environment using KREONET-S show the result.
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Masrurroh, Aidatul, and Masriyah Masriyah. "Pengembangan Perangkat Pembelajaran Kesebangunan Bangun Datar Berbasis Teori Van Hiele Untuk Meningkatkan Kemampuan Berpikir Tingkat Tinggi Siswa." MATHEdunesa 9, no. 1 (2020): 61–68. http://dx.doi.org/10.26740/mathedunesa.v9n1.p61-68.
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In implementing the 2013 curriculum, Higher Order Thinking Skills (HOTS) must be integrated into learning activities. Similarity are sub material of similarity and congruence that students must learn. In fact, the higher order thinking skills of junior high school students in similarity material is low. To overcome this problem, it is necessary to develop a learning materials for learning in the form of plane similarity according to the level of student thinking in geometry, which is based on Van Hiele's theory to improve students' higher-order thinking skills. Van Hiele's theory was chosen because it suggests the development of students' thinking in learning of geometry occurs through five levels sequentially so that learning devices can be developed according to the level of van Hiele students. The purpose of this research is to obtain a description of the learning materials of plane similarity based on van Hiele theory based on van Hiele theory to improve students' high-level thinking skills that are valid, practical, and effective. This type of research is a research development using the 4-D model proposed by Thiagarajan then simplified to a 3-D model. Validation of learning devices, participant observation, questionnaires, and tests are the data collection techniques used. The results showed that the RPP, LKS, and THB were said to be valid then, the learning materials was declared valid; the management of learning is said to be good, the overall evaluation on the validation sheet of the learning materials is stated to be used, and the percentage of active student activities at the second meeting and the third meeting respectively is 91.25% and 91.25% then, the learning kit is declared practical; and the percentage of positive responses of students by 71% and an increase in higher order thinking skills seen from the results of the N-Gain pretest and posttest of 0,728 categorized as high then, the learning device is declared effective. Keywords: learning materials, plane similarity, van hiele’s theory, higher order thinking skills.
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Timotijevic, Gordana, Mira Milisavljevic, Dragana Nikolic, et al. "Establishment and in-house validation of stem-loop RT PCR method for MicroRNA398 expression analysis." Genetika 47, no. 2 (2015): 405–16. http://dx.doi.org/10.2298/gensr1502405t.
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MicroRNAs (miRNAs) belong to the class of small non-coding RNAs which have important roles throughout development as well as in plant response to diverse environmental stresses. Some of plant miRNAs are essential for regulation and maintenance of nutritive homeostasis when nutrients are in excess or shortage comparing to optimal concentration for certain plant species. Better understanding of miRNAs functions implies development of efficient technology for profiling their gene expression. We set out to establish validate the methodology for miRNA gene expression analysis in cucumber grown under suboptimal mineral nutrient regimes, including iron deficiency. Reverse transcription by ?stem-loop? primers in combination with Real time PCR method is one of potential approaches for quantification of miRNA gene expression. In this paper we presented a method for ?stem loop? primer design specific for miR398, as well as reaction optimization and determination of Real time PCR efficiency. Proving the accuracy of this method was imperative as ?stem loop? RT which consider separate transcription of target and endogenous control. The method was verified by comparison of the obtained data with results of miR398 expression achieved using a commercial kit based on simultaneous conversion of all RNAs in cDNAs.
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Goebel, Camille A., Aminata Umoja, and Robert L. DeHaan. "Providing Undergraduate Science Partners for Elementary Teachers: Benefits and Challenges." CBE—Life Sciences Education 8, no. 3 (2009): 239–51. http://dx.doi.org/10.1187/cbe.08-07-0041.
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Undergraduate college “science partners” provided content knowledge and a supportive atmosphere for K–5 teachers in a university–school professional development partnership program in science instruction. The Elementary Science Education Partners program, a Local Systemic Change initiative supported by the National Science Foundation, was composed of four major elements: 1) a cadre of mentor teachers trained to provide district-wide teacher professional development; 2) a recruitment and training effort to place college students in classrooms as science partners in semester-long partnerships with teachers; 3) a teacher empowerment effort termed “participatory reform”; and 4) an inquiry-based curriculum with a kit distribution and refurbishment center. The main goals of the program were to provide college science students with an intensive teaching experience and to enhance teachers' skills in inquiry-based science instruction. Here, we describe some of the program's successes and challenges, focusing primarily on the impact on the classroom teachers and their science partners. Qualitative analyses of data collected from participants indicate that 1) teachers expressed greater self-confidence about teaching science than before the program and they spent more class time on the subject; and 2) the college students modified deficit-model negative assumptions about the children's science learning abilities to express more mature, positive views.
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Rajulianto, Rajulianto, and Yeka Hedriyani. "PERANCANGAN APLIKASI ANDROID ABSENSI SISWA PADA SEKOLAH SMK NEGERI 5 PADANG." Voteteknika (Vocational Teknik Elektronika dan Informatika) 7, no. 4 (2020): 225. http://dx.doi.org/10.24036/voteteknika.v7i4.106718.
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The purpose of this study was to design an application for attendance at the SMK Negeri 5 Padang school which was used as student absenteeism when the teaching and learning activities took place and to see reports of student attendance. The attendance process is carried out by utilizing a smartphone through a client-server based Android application, so that the attendance process no longer takes the timesheet on the picket table and records it on paper. The attendance application design was built using object-oriented programming methods using UML (Unified Modeling Language) modeling, among others: Context Diagrams, Use Case Diagrams, Activity Diagrams and Class Diagrams. On the server side the system is built using PHP (Hypertext Preprocessor) with CSS (Cascading Style Sheets) as an additional language and as an editor using SublimeText, while applications on the client side use the Java Development Kit (JDK) language and use MySQL as a database. The student absentee application at the SMK 5 Padang is produced namely, the application on the server side with a web display that is used for client management, while on the client side will produce an application used to retrieve student attendance data and view student attendance data reports Keywords: Sudent attendence, Android, Client-Server, PHP(Hypertext Preprocessor).
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Pyrkova, A. YU, and ZH E. Temirbekova. "Compare encryption performance across devices to ensure the security of the IOT." Indonesian Journal of Electrical Engineering and Computer Science 20, no. 2 (2020): 894. http://dx.doi.org/10.11591/ijeecs.v20.i2.pp894-902.
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The Internet of Things (IoT) combines many devices with various platforms, computing capabilities and functions. The heterogeneity of the network and the ubiquity of IoT devices place increased demands on security and privacy protection. Therefore, cryptographic mechanisms must be strong enough to meet these increased requirements, but at the same time they must be effective enough to be implemented on devices with disabilities. One of the limited devices are microcontrollers and smart cards. This paper presents the performance and memory limitations of modern cryptographic primitives and schemes on various types of devices that can be used in IoT. In this article, we provide a detailed assessment of the performance of the most commonly used cryptographic algorithms on devices with disabilities that often appear on IoT networks. We relied on the most popular open source microcontroller development platform, on the mbed platform. To provide a data protection function, we use cryptography asymmetric fully homomorphic encryption in the binary ring and symmetric cryptography AES 128 bit. In addition, we compared run-time encryption and decryption on a personal computer (PC) with Windows 7, the Bluetooth Low Energy (BLE) Nano Kit microcontroller, the BLE Nano 1.5, and the smartcard ML3-36k-R1.
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DeVries, Michelle, Mary Valentine, and Patricia Mancos. "Protected Clinical Indication of Peripheral Intravenous Lines: Successful Implementation." Journal of the Association for Vascular Access 21, no. 2 (2016): 89–92. http://dx.doi.org/10.1016/j.java.2016.03.001.
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Abstract Background: A large, urban community hospital developed an insertion bundle to support the safe implementation of a policy of extended dwell time (clinical indication) for inpatient peripheral intravenous lines (PIVs). Methods: Internal evaluation of practices through direct observations as well as evidence-based guidelines and historic data on PIV-related bloodstream infections helped drive the bundle elements. A surveillance plan was in place to continue measurement of these outcomes during the postimplementation period. Results: At 12 months following implementation, the organization documented a 37% reduction (P = .03) in primary bacteremias (combining PIV and central line-associated bloodstream [CLABSI] infections) and a 19% percent reduction in PIV bloodstream infections. CLABSI rates were also reviewed, as 20% of CLABSI were noted to also have peripheral access present during the year prior to implementation. CLABSI standardized infection ratios for the publicly reported intensive care units decreased from 1.3 to 0.32 (P = .02). In addition, intravenous line start kit use decreased 48% during the year following bundle implementation. Conclusions: Careful planning and development of an education bundle and an insertion bundle in a community hospital setting allowed for longer dwell times and a trend of decreased bloodstream infections.
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Mortimore, Vivien, Michelle Richardson, and Sally Unwin. "Identifying adverse childhood experiences in maternity services." British Journal of Midwifery 29, no. 2 (2021): 70–80. http://dx.doi.org/10.12968/bjom.2021.29.2.70.
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Background Maternity services have a unique opportunity to support women and families to build resilience and mitigate against the harmful impact of parental exposure to adverse childhood experiences (ACEs) but, most importantly, to prevent exposure to ACEs in future generations. Aim To identify ACEs in families who use maternity services in order to improve the professional response to risk, build parental resilience and strengthen parenting capacity. Methods A quality improvement project piloted an ACEs screening tool with 44 women and their partners when booking for maternity services. Implementation was supported by the development of a range of bespoke tools. Evaluation took place through quantitative data analysis and qualitative feedback from professionals and parents. Findings The use of the ACEs screening tool successfully identified ACEs which would otherwise not have been known using the previous antenatal booking questions. The bespoke tool kit was well-received by women, their partners and professionals. Identification and discussion of ACEs enabled appropriate support to be offered. Conclusion Identifying ACEs in maternity services and offering additional support requires further work before wider implementation. These interventions have the potential to reduce risk, build resilience and strengthen parenting capacity which could protect infants from experiencing a cycle of adversity.
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Vireque, A. A., L. S. A. Camargo, R. V. Serapião, et al. "255 PREIMPLANTATION DEVELOPMENT AND EXPRESSION OF Bax AND Hsp-70 GENES IN BOVINE EMBRYOS PRODUCED FROM OOCYTES MATURED IN CHEMICALLY DEFINED IVM MEDIUM WITHOUT GONADOTROPHINS." Reproduction, Fertility and Development 20, no. 1 (2008): 207. http://dx.doi.org/10.1071/rdv20n1ab255.
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The culture environment affects both the maternal and the embryonic expression of genes, and is likely to alter both oocyte and embryo developmental competence. Search for better and less variable culture conditions simulating the in vivo environment has led to the development of defined culture media, with lower negative impact on the molecular reprogramming of oocytes and embryos. This study aimed to evaluate the embryo development and relative expression of Hsp-70 and Bax transcripts in bovine blastocysts produced from oocytes matured in chemically defined IVM medium supplemented with insulin-like growth factor (IGF)-I, insulin, and polyvinyl alcohol (PVA) or polyvinylpyrrolidone 40 (PVP) without FSH and LH. Immature cumulus–oocyte complexes (COCs) from slaughtered cows were matured for 24 h in α-MEM plus IGF-1 and insulin and supplemented with 0.1% PVA (treatment 1; n = 410) or 0.1% PVP (treatment 2; n = 350). Neither FSH nor LH was used in both treatments. The control group consisted of COCs matured in TCM plus FSH and 10% estrous cow serum (n = 400). In vitro fertilization took place in Fert-Talp droplets for 22 h. Presumptive zygotes were co-cultured with cumulus cells in CR2aa supplemented with 10% fetal calf serum under mineral oil in a humidified atmosphere of 5% CO2 at 38.5�C. Preimplantation embryo development was determined by cleavage, blastocyst, and hatching rates. For RNA extraction, blastocysts at Day 8 post-fertilization were frozen in liquid nitrogen and subsequently thawed. Total RNA extraction was performed using Rneasy Micro kit (Qiagen, Valencia, CA, USA) and first strand synthesized using Superscript III First Strand Synthesis kit (Invitrogen, Chicago, IL, USA). Relative quantification was performed in duplicate using real-time PCR (ABI Prism 7000 Applied Biosystem, Foster City, CA, USA); reactions consisted of a mixture of iTaq SYBR Green Supermix with ROX (Bio-Rad, Waltham, MA, USA) with cDNA equivalent to 0.8 embryos and specific primers for Hsp-70 and Bax genes, using as endogenous reference the expression of H2a gene. Data of embryo development were analyzed by chi-square test and calculations of relative quantification were performed by REST� (Relative Expression Software Tool; Pfaffl et al. 2002 Nucl. Acids Res. 30, e36), using the value found in the control group as calibrator. Cleavage rate was higher (P < 0.05) for the control group (67%) than for treatments 1 (54%) and 2 (59%). Nevertheless, there was no difference (P > 0.05) in blastocyst (40.2%, 45.0%, and 43.5%) and hatching (78%, 77%, and 75%) rates among treatments 1 and 2 and the control group, respectively. Similarly, no difference (P > 0.05) in relative expression of Hsp-70 and Bax transcripts (0.69 � 0.69 and 0.53 � 0.32 for treatment 1, and 1.08 � 0.75 and 0.70 � 0.47 for treatment 2) in comparison to the calibrator group was detected. These results show that bovine oocytes can be matured in serum-free and gonadotrophin-free medium supplemented with PVA or PVP without altering post-cleavage development and relative expression of some genes associated with stress and apoptosis.
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Perkins, Archibald S., Sharon Lin, Jacob delCampo, Fernando Camargo, and Kimberly Lezon-Geyda. "Analysis of a LacZ Knock-In Allele of MDS1 Indicates a Critical Role in Hematopoietic Development." Blood 108, no. 11 (2006): 444. http://dx.doi.org/10.1182/blood.v108.11.444.444.
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Abstract The MDS1-EVI1 locus is of considerable interest due to its role in myeloid malignancies and dysplasias. It is well established now that the locus has two different transcription start sites (TSS) located 0.5 Mb apart, and these have the capacity to encode different isoforms, which variably contain zinc finger DNA binding domains and a SET-like domain that may have histone modifying ability. In order to better understand the biological role of this locus, we knocked in a lacZ allele into the Mds1 (upstream) TSS by homologous recombination in ES cells and created mice harboring this modified allele (K. Lezon-Geyda, S. Lin, G. Steele-Perkins et al, in preparation). By staining for beta-galactosidase activity, we documented the distribution of Mds1 activity during embryonic development and in the adult. During development, five major organ systems showed expression: musculoskeletal, renal, cardiac, neural, and hematopoietic, and in the latter three, there was a striking and highly specific spatiotemporal pattern of expression suggesting that Mds1-Evi1 plays important regulatory roles. In the developing heart, staining was seen in the anterior heart field specifically during the formation of the cardiac outflow tract, with significant spatiotemporal overlap with Mef2c, which encodes an important cardiac transcriptional regulatory protein. Thereafter, expression in the heart is very low. Beta-gal staining in the hematopoietic system in the embryo is limited to the clusters of nascent hematopoietic progenitors that develop at day 9.5 p.c. in the ventrolateral wall of the dorsal aorta and bud into the vascular lumen. Strikingly, we see no staining in other endothelium, nor in the fetal liver of 12.5–14.5 day embryos, wherein the majority of fetal hematopoiesis takes place. In adult bone marrow, there is beta-gal activity exclusively in the lin− c-kit+ Sca1+ progenitor population, with all of the beta-gal-positive cells being in the progenitor pool, and nearly all of the progenitor cells staining. While homozygous mice are viable, they are small, kyphotic, and have a shortened lifespan. Morphologic and quantitative analysis of the peripheral blood failed to reveal any significant abnormality. To assess the function of the hematopoietic system more rigorously, competitive repopulations of homozygous Mds1-deficient marrow progenitors with wildtype progenitors were performed. Within several weeks after transplant, the Mds1−/− cells were undetectable in the recipients, revealing that the homozygous Mds1-null bone marrow progenitors are deficient in their repopulating ability. To identify what function Mds1-Evi1 plays in hematopoetic cells, we used shRNA to suppress its expression in the myeloid cell lines 32Dcl3 and DA-1. This revealed an increase in steady state levels of cell death, as documented by histone release, TUNEL staining, and caspase activation. These data suggest that a primary role for the Mds1-Evi1 locus in hematopoietic cells is to promote their survival, thus allowing normal expansion at the progenitor stage.
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Haines-Delmont, Alina, Gurdit Chahal, Ashley Jane Bruen, et al. "Testing Suicide Risk Prediction Algorithms Using Phone Measurements With Patients in Acute Mental Health Settings: Feasibility Study." JMIR mHealth and uHealth 8, no. 6 (2020): e15901. http://dx.doi.org/10.2196/15901.
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Background Digital phenotyping and machine learning are currently being used to augment or even replace traditional analytic procedures in many domains, including health care. Given the heavy reliance on smartphones and mobile devices around the world, this readily available source of data is an important and highly underutilized source that has the potential to improve mental health risk prediction and prevention and advance mental health globally. Objective This study aimed to apply machine learning in an acute mental health setting for suicide risk prediction. This study uses a nascent approach, adding to existing knowledge by using data collected through a smartphone in place of clinical data, which have typically been collected from health care records. Methods We created a smartphone app called Strength Within Me, which was linked to Fitbit, Apple Health kit, and Facebook, to collect salient clinical information such as sleep behavior and mood, step frequency and count, and engagement patterns with the phone from a cohort of inpatients with acute mental health (n=66). In addition, clinical research interviews were used to assess mood, sleep, and suicide risk. Multiple machine learning algorithms were tested to determine the best fit. Results K-nearest neighbors (KNN; k=2) with uniform weighting and the Euclidean distance metric emerged as the most promising algorithm, with 68% mean accuracy (averaged over 10,000 simulations of splitting the training and testing data via 10-fold cross-validation) and an average area under the curve of 0.65. We applied a combined 5×2 F test to test the model performance of KNN against the baseline classifier that guesses training majority, random forest, support vector machine and logistic regression, and achieved F statistics of 10.7 (P=.009) and 17.6 (P=.003) for training majority and random forest, respectively, rejecting the null of performance being the same. Therefore, we have taken the first steps in prototyping a system that could continuously and accurately assess the risk of suicide via mobile devices. Conclusions Predicting for suicidality is an underaddressed area of research to which this paper makes a useful contribution. This is part of the first generation of studies to suggest that it is feasible to utilize smartphone-generated user input and passive sensor data to generate a risk algorithm among inpatients at suicide risk. The model reveals fair concordance between phone-derived and research-generated clinical data, and with iterative development, it has the potential for accurate discriminant risk prediction. However, although full automation and independence of clinical judgment or input would be a worthy development for those individuals who are less likely to access specialist mental health services, and for providing a timely response in a crisis situation, the ethical and legal implications of such advances in the field of psychiatry need to be acknowledged.
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Lee, Sung-UK, Manami Maeda, Nagisa Sakurai, Freddy Radtke, and Takahiro Maeda. "LRF Is Indispensable for Hematopoietic Stem Cell Function Via Blocking Notch1-Mediated T Cell-Instructive Signals in the Bone Marrow Niche." Blood 114, no. 22 (2009): 81. http://dx.doi.org/10.1182/blood.v114.22.81.81.
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Abstract Abstract 81 Hematopoietic stem cells (HSC) have the ability to self-renew and give rise to all hematopoietic lineage cells. Understanding signals that regulate the balance between self-renewal and differentiation of HSCs is an important issue in stem cell biology as well as regenerative medicine. Notch signals are critical regulators of the lymphoid lineage fate, but their role in adult HSC function is currently under debate. We explored the role of the LRF (Leukemia/Lymphoma Related Factor), a Notch repressor (also known as Zbtb7a, pokemon, OCZF and FBI-1) in HSC function, as it plays key roles in embryonic development, oncogenesis, and hematopoiesis. Conditional inactivation of the LRF gene in mouse HSCs (LRFF/FMx1-Cre mice) led to the development of CD4/CD8 DP (double positive) T-cells at the expense of B-cell development in the bone marrow (BM) in a Notch-dependent manner. Absolute numbers of the most primitive HSCs (LT-HSCs), defined as CD150+CD48−Flt3−Vcam-1+IL7Rα−LSK (Lin−Sca1+c-Kit+), were significantly reduced, while lymphoid-biased multi-potential progenitors (LMPPs: CD150−CD48+Flt3+Vcam-1+/−IL7Rα−LSK) and common lymphoid progenitors (CLPs: Lin−CD150−CD48+Flt3+Vcam-1−IL7Rα+) were barely detectable in LRFF/FMx1-Cre mice one month after pIpC injection. Enhanced T cell development and concomitant loss of B cell development was also seen in LRF−/− fetal liver (FL). Lin−IL7Rα+c-Kit+PIR+ (Paired Immunoglobulin-like receptors) T cell precursors were significantly increased in LRF−/− FL, indicating that Notch-mediated aberrant lymphoid fate determination also takes place during fetal hematopoiesis. To address which Notch gene(s) are targeted by LRF, we studied the HSC/progenitor population of conditional LRF knockout (LRFF/FMx1-Cre) as well as LRF/Notch1 double conditional knockout mice (LRFF/FNotch1F/FMx1-Cre). In the absence of Notch1, normal B cell development was restored in LRFF/FMx1-Cre mice. Reduction of LT-HSCs in LRFF/FMx1-Cre resulted from high Notch1 activity, as loss of Notch1 rescued LT-HSC numbers, suggesting that LRF functions to maintain HSCs and normal lymphoid fate by blocking Notch1. HSCs in active cell cycle are sensitive to 5-fluoro-uracil (5-FU) treatment, which causes remaining dormant HSCs to be recruited into the cell cycle to rapidly produce new cells and to quickly re-establish the hematopoietic system. To examine the self-renewal capacity of LRF deficient LT-HSC, LRFF/FMx1-Cre mice were treated with 5-FU after pIpC injection and the recovery of LT-HSC numbers examined. While control LT-HSC numbers recovered to pretreatment levels 3 wk after 5-FU treatment, levels in LRFF/FMx1-Cre mice remained low, accompanied by DP T cell development in the BM. Furthermore, after 5-FU treatment, LT-HSC numbers of LRFF/FNotch1F/FMx1-Cre were compatible to those of control and LRFF/FMx1-Cre mice, indicating that lack of self-renewal capacity in LRF deficient LT-HSCs was due to excessive differentiation toward T cells caused by Notch1. In support of this idea, when mice were given 5-FU weekly as a challenge to assess their HSC function in vivo, the survival percentage in LRFF/FMx1-Cre mice was much lower than in controls (0% versus 50% in 1 month, P <0.0001) and that of LRFF/FNotch1F/FMx1-Cre mice was compatible to controls. Serial bone marrow transplant experiments further demonstrated functional defects of LRF deficient HSCs, as they failed to reconstitute the hematopoietic system in secondary recipients. Microarray analysis and subsequent Gene Set Enrichment Analysis demonstrated upregulation of genes that were enriched in progenitor compartments. Since LRF can act as a transcriptional repressor, mRNA levels of Notch receptors and Notch ligands were examined using the same data set. A Notch target gene Hes1, but not Notch1 itself, was upregulated, and increased levels of Hes1 was also confirmed by real-time q-PCR in FACS-sorted LT-HSCs, as well as in 10.5 d.p.c whole embryos. These data suggest that LRF does not transcriptionally regulate Notch1, as LRF loss led to Notch1 target gene activation at the LT-HSC level without affecting Notch1 mRNA. Our genetic studies clearly indicate that LRF is indispensable for the maintenance of the HSC pool by repressing T cell-instructive signals mediated by Notch1 in the BM niche. Our findings shed new light on the regulatory mechanisms underlying the balance between HSC self-renewal and differentiation. Disclosures: No relevant conflicts of interest to declare.
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Handoyono, Nurcholish Arifin. "Development of Learning Media for Motorcycle Chassis Training Kit." Journal of Vocational Education Studies 4, no. 1 (2021): 28. http://dx.doi.org/10.12928/joves.v4i1.3413.
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This research aims to determine the development process and the feasibility of learning media for motorcycle chassis training kit at SMK Muhammadiyah 1 Bambanglipuro. The type of research used is R&D. The research subjects were 32 students of class X TBSM SMK Muhammadiyah 1 Bambanglipuro. The data collection instruments used observation and questionnaires. The data analysis technique used the evaluation criteria analysis to determine the feasibility of learning media. The results showed that: (1) The development process went through several stages, namely: (a) problem background; (b) problem identification; (c) development ideas; (d) pre-production stage (tools and materials); (e) production stage; (f) product development; (g) validation and revision; (h) feasibility test; and (i) wearable products; and; (2) Learning media for motorcycle chassis training kit are categorized as very suitable for use in learning with the results of validation of media experts by 90%, material experts by 95%, small group trial of 85.24%, and large group trial of 83.94%.
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Molefi, Tsholofelo. "Development of an Accident and Emergency Triage Mobile App Using Open Data Kit." Iproceedings 5, no. 1 (2019): e15248. http://dx.doi.org/10.2196/15248.
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Background The process of triaging is performed as an effective solution to balance limited resources against high patient volumes, based on an assessment of the patient’s medical condition and the application of an established patient categorization protocol. In Princess Marina Hospital (PMH), a national referral government hospital in the capital city of Botswana, the Princess Marina Hospital Accident and Emergency Centre Triage Scale (PATS) has been in use since 2010. Because the rules of these triage scales are very well defined, these protocols have been shown to be amenable to translation into computer algorithms. Thus, clinical decision support systems (CDSSs) that can assist with information management to support clinicians’ decision-making abilities can be developed, leading to improved healthcare quality and patient safety. Objective This study aims to determine the feasibility of development of a mobile triage app based on the adult PATS using Open Data kit (ODK) open source software to be used as a CDSS on smartphones and tablet computers for correct patient categorization. Methods A user-centered design approach was used in designing the app, with participants recruited from the staff at the Accident and Emergency Department (A&E) at PMH. Forty clinical vignettes were used in the evaluation of the performance of the app as compared to the paper-based system currently in use with the emergency physician at PMH providing the gold standard categorization of these vignettes. Usability testing was also performed. Results The app scored 90% (n=36) of the vignettes correctly, as compared to the paper-based system which scored 82.5% (n=33) of the vignettes correctly. Both systems achieved an over-triage score of 7.5% with an equal number of vignettes over-triaged (n=3). The results of the chi-square test indicate that the difference in triage scores between the paper-based system and the mobile app is statistically significant at P=.001 in favour of the ODK app. An overall positive outcome was also achieved in the usability test with ease of use and speed of triage determined to be the most recurring themes in the user feedback survey. While the app does not require an internet connection for triaging patients, a reliable wireless internet connection is required to upload data to the server for viewing by medical officers and physicians in real time, and this can be provided by the hospital as part of the Botswana government eHealth strategy. Additionally, the app developed in this research allows for data collection up to the point of triage categorization, meaning that a separate form would be required for capturing the rest of the information on the PMH A&E triage form. Conclusions The triage app developed in this research was found to determine the triage category of patient vignettes more accurately than the traditional paper-based system based on PATS triage guidelines with good results obtained in usability testing. Future work includes use of the app developed in this research in a live setting involving real patients in the A&E in PMH.
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Heo, Jeongpil, Kiseog Kim, Inseub Lim, and Jocheol Jin. "Development of a Kit for Realtime transmission of data acquired by Earthquake accelerometers." Journal of The Korean Society of Disaster Information 10, no. 2 (2014): 254–62. http://dx.doi.org/10.15683/kosd.2014.10.2.254.
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Nishida, Keigo, Lin Wang, Eiichi Morii, et al. "Requirement of Gab2 for mast cell development and KitL/c-Kit signaling." Blood 99, no. 5 (2002): 1866–69. http://dx.doi.org/10.1182/blood.v99.5.1866.
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Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell development depends on stem cell factor (Kit ligand) and its receptor, c-Kit. Gab2 is an adaptor molecule containing a pleckstrin homology domain and potential binding sites for SH2 and SH3 domains. Gab2 is phosphorylated on tyrosine after stimulation with cytokines and growth factors, including KitL. Gab2-deficient mice were created to define the physiological requirement for Gab2 in KitL/c-Kit signaling and mast cell development. In Gab2-deficient mice, the number of mast cells was reduced markedly in the stomach and less severely in the skin. Bone marrow–derived mast cells (BMMCs) from the Gab2-deficient mice grew poorly in response to KitL. KitL-induced ERK MAP kinase and Akt activation were impaired in Gab2-deficient BMMCs. These data indicate that Gab2 is required for mast cell development and KitL/c-Kit signaling.
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Rodewald, Hans-Reimer, Claudia Waskow та Corinne Haller. "Essential Requirement for C-KIT and Common γ Chain in Thymocyte Development Cannot Be Overruled by Enforced Expression of Bcl-2". Journal of Experimental Medicine 193, № 12 (2001): 1431–38. http://dx.doi.org/10.1084/jem.193.12.1431.
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The thymus in mice lacking both the receptor tyrosine kinase c-kit and the common cytokine receptor γ chain (γc) is alymphoid because these receptors provide essential signals at the earliest stages of thymocyte development. The signals transduced by these receptors potentially regulate proliferation, survival, or differentiation, but the contribution of each receptor to distinct intracellular signaling cascades is only poorly defined. Here, we have examined whether enforced expression of Bcl-2 can rescue thymocyte development in c-kit and γc single or double mutant mice. A bcl-2 transgene (Eμ-bcl-2-25; expressed in the T cell lineage) was introduced into (a) c-kit and γc wild-type (c-kit+γc+bcl+), (b) c-kit–deficient (c-kit−γc+bcl+), (c) γc-deficient (c-kit+γc−bcl+), or (d) c-kit and γc double-deficient mice (c-kit−γc−bcl+). The bcl-2 transgene was functionally active in wild-type and c-kit or γc single mutants, as it promoted survival of ex vivo isolated thymocytes, including pro-T cells. In vivo, however, transgenic Bcl-2 did not release T cell precursors from their phenotypic block and failed to increase progenitor or total thymocyte cellularity in c-kit or γc single or double mutants. These data argue strongly against a role for Bcl-2 as a key mediator in signaling pathways linked to cytokine and growth factor receptors driving early thymocyte development.
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Permana, H., and B. H. Iswanto. "Development of Thermal Radiation Experiments Kit Based on Data Logger for Physics Learning Media." IOP Conference Series: Materials Science and Engineering 335 (April 2018): 012080. http://dx.doi.org/10.1088/1757-899x/335/1/012080.
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Comandone, Alessandro, Elisa Berno, Simona Chiadò Cutin, and Antonella Boglione. "The importance of molecular biology in development, prognosis, treatment and resistance to targeted therapy in gastrointestinal stromal tumors." Oncology Reviews 2, no. 2 (2011): 69. http://dx.doi.org/10.4081/oncol.2008.69.
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Gastrointestinal stromal tumors (GISTs) are the commonest mesenchymal tumors of the gastroenteric tract, and are generally believed to originate from the neoplastic transformation of the interstitial cells of Cajal, the pacemaker structures of the stomach and intestine. Exon and genetic mutations (point/deletions) are fundamental for the development of GISTs: the constitutional characteristic of this neoplasm is the presence of the cell surface Kit receptor. Kit is the product of the proto-oncogene cKit, situated in chromosome 4. Ninety-eight percent of GISTs express mutated isoforms of Kit or of PDGFRA (Platelet growth factor receptor a). Kit mutation is the basic condition for autophosphorylation of tyrosine kinase residues in proteins. Autophosphorylation initiates pathogenetic processes in Cajal cells, toward a neoplastic transformation. Imatinib mesilate and, more recently, sunitinib are tyrosine kinase inhibitors, specific antagonists for Kit and PDGFRA, with good activity against GISTs. Most molecular and clinical data currently available concern imatinib. Exon mutations are strategic as prognostic and as predictive factors. In recent years, much evidence suggests that survival, response to therapy and resistance to imatinib are related to different mutations. In the near future, GIST patients will receive treatment differentiated by expressed Kit and PDGFRA mutations, thus truly individualized therapy.
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Wang, Zhidong, Yingdong Ni, Zifan Zhang, et al. "Intelligent Distribution Network Information Processing Based on Power Data Virtual Plane." Applied Sciences 10, no. 3 (2020): 736. http://dx.doi.org/10.3390/app10030736.
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Due to the diversity and complexity of distribution networks, the classical modular software development method may face the difficulty in modular division, data sharing and collaboration of different specialties. Inspired by the idea of separating the control plane from the data forwarding plane in software-defined networking (SDN), a method of power data virtual plane is proposed in this paper to improve software development efficiency. Layered processing of power data virtual plane is designed to meet the diversity characteristics of intelligent distribution network and the multi-source and heterogeneous characteristics of information. This paper introduces the design idea and implementation process of virtual plane in detail. The main component of the power data virtual plane, power data warehouse and application scheduling are presented. Finally, the performance of the proposed virtual plane method is verified by practical distribution network examples with different communication networks and information.
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Hobson, Hartley. "Resource Review: Youth and Adult Leaders for Program Excellence: A Practical Guide for Program Assessment and Action Planning." Journal of Youth Development 1, no. 3 (2007): 118–20. http://dx.doi.org/10.5195/jyd.2007.380.
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The Youth and Adult Leaders for Program Excellence (YALPE Resource Kit) was developed to assist groups working to promote positive youth development. The Kit includes a variety of assessment tools and templates for data analysis and report writing. The tools are grounded in research on youth development and are user-friendly for adults and youth.
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Suwardi, Suwardi, Erik Ayatullah, and Haidul Haidul. "PENGEMBANGAN KIT PRAKTIKUM ELEKTRONIKA DASAR II BERBASIS SIMULATOR PROTEUS UNTUK MENINGKATKAN KEMAMPUAN MAHASISWA DALAM PEMECAHAN MASALAH." Jurnal Kumparan Fisika 4, no. 1 (2021): 9–16. http://dx.doi.org/10.33369/jkf.4.1.9-16.
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ABSTRAK Penelitian ini bertujuan untuk mengembangkan kit praktikum Elektronika Dasar II berbasis simulator Proteus untuk meningkatkan kemampuan pemecahan masalah mahasiswa.Hasil observasi dalam prapenelitian menunjukkan bahwa mahasiswa kesulitan merangkai komponen elektronika, kekurangan waktu praktikum, dan kesulitan dalam mendapatkan data.Untuk mengatasi permasalahan ini dilakukan pengembangan kit praktikum Elektronika Dasar IIberbasis menggunakan simulator Proteus. Melalui kit praktikum mahasiswa fokus pada proses pengambilan data dan menganalisis sinyal keluaran rangkaian elektronika.Sedangkan simulator Proteus dapat membantu dalam mengamati gejala-gejala yang tidak dapat diamati langsung dan sebagai data pembanding. Penelitian ini merupakan jenis penelitian dan pengembangan dengan tahapan adalah analisis kebutuhan, pengembangan produk awal, validasi ahli, uji lapangan dan revisi produk. Penelitian ini dilakukan di Laboratorium Fisika FMIPA Universitas Bengkulu semester ganjil 2018/2019dengan subyek penelitian ini adalah 22 mahasiswa. Pengumpulan data dilakukan menggunakan metode observasi dan kuesioner yang dianalisis secara deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa kit praktikum yang berhasil dikembangkan terdiri dari delapan percobaan yaitu penguat common drain, common source, emitor ditanahkan, pushpull, respon frekuensi rendah, inverting dan non inverting, integrator dan diferensiator, dan filter aktif. Kelayakan kit praktikum sebagai media pembelajaran di laboratorium berdasarkan validasi ahli sebesar 82,50% (sangat layak) dan berdasarkan pengguna sebesar 82, 64% (sangat layak). Kata kunci: kit praktikum elektronika dasar II, simulator proteus, praktikum berbasis masalah ABSTRACT This study aims to develop a Basic Electronics II practicum kit based on the Proteus simulator to improve students' problem solving abilities. The results of observations in the pre-study showed that students had difficulty assembling electronic components, lack of practicum time, and difficulties in obtaining data. To overcome this problem, the development of Basic Electronics II based practicum kit using the Proteus simulator is carried out. Through the practicum kit students focus on the process of data retrieval and analyzing the electronic circuit output signal. Whereas the Proteus simulator can help in observing symptoms that cannot be observed directly and as comparative data. This research is a type of research and development with stages are needs analysis, initial product development, expert validation, field testing and product revision. This research was conducted in the Physics Laboratory of the University of Bengkulu FMIPA odd semester 2018/2019 with the subjects of this study were 22 students. Data collection was carried out using observation methods and questionnaires which were analyzed quantitatively descriptively. The results showed that the practicum kit that was successfully developed consisted of eight experiments namely common drain amplifier, common source, ground emitter, pushpull, low frequency response, inverting and non-inverting, integrators and differentiators, and active filters. The feasibility of the practicum kit as a learning media in a laboratory based on expert validation is 82.50% (very feasible) and based on the user is 82, 64% (very feasible). Keywords: basic electronics II practicum kit, proteus simulator, problem solving laboratory
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Fadilah, Sofiana Nur, Siti Marfu'ah, and Surjani Wonorahardjo. "Edu-Kit “Our Coffee” Development on Problem Based Learning Model for Vocational Agribusiness and Agrotechnology Programs on Material Separation Mixture." International Journal of Interactive Mobile Technologies (iJIM) 14, no. 12 (2020): 41. http://dx.doi.org/10.3991/ijim.v14i12.15571.
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<p>Student achievement in chemistry is relatively low because chemistry topics are not integrated with students’ expertise programs. The lack of variation in teaching material and learning model also reduces the motivation to study chemistry. One of the science-chemistry materials in vocational high schools is separation of mixture, taught in the agribusiness and agro technology specialization programs. Many business sectors such as cafes are starting to stand in the community, requiring coffee serving skills and also knowledge about coffee that can be viewed from the chemistry side. Chemical changes due to coffee cultivation and the processes through which coffee can be consumed can be learned through interactive and communicative teaching materials</p><p>One way to present and integrate coffee topics in learning is to develop an Edu-Kit which contains problems in coffee that are integrated with separation of mixture topic. Separation of mixture is contained in the 2013 Curriculum. The choice of problem-based learning models is assessed according to the characteristics of vocational learning, which is to present real problems and solve them while learning the concepts needed. The Edu-Kit development uses the research and development (R&amp;D) method of Borg and Gall. E-book was chosen as an application in the development of Edu-Kit which includes text, sound, picture and video. Validation data were collected from 2 validators and readability tests by students. Data were analyzed using quantitative and qualitative techniques. The effectiveness of the Edu-Kit uses quasi experimental, pretest and posttest designs. There were 62 samples determined by the saturation sampling technique. The sample is divided into two classes, namely the experimental and control classes. Edu-kit effectiveness from posttest scores, analyzed using the Mann Whitney U Test using SPSS. The results of Edu-kit development obtained an average percentage of validation of 91.90% with very decent criteria. While the results of the effectiveness test showed that the use of Edu-kit made students' understanding better in mixed separation material.</p>
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Fitria, Rahmi, Nahor Murani Hutapea, and H. Zulkarnain H. Zulkarnain. "Development of Mathematics Learning Devices by Applying Problem Based Learning to Increase Students Mathematical Solving Skills of Class VII Junior High School." Journal of Educational Sciences 4, no. 2 (2020): 368. http://dx.doi.org/10.31258/jes.4.2.p.368-379.
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This research was motivated by the low ability of Mathematical Problem Solving (KPMM) of students. In order to improve KPMM, teachers can do designing the learning process. This study aims to develop mathematical learning tools that are valid, practical and effective. The development model used the Borg and Gall model. The research instrument consisted of syllabus validation sheets, lesson plane (RPP), student worksheet (LKPD), observability of implementation, student questionnaire responses and KPMM test instruments. The result shows the mathematics learning kit using the PBL model was already valid which is for the syllabus was 85.41%, RPP was 85.11%, LKPD was 88.67% and the test instrument was 81.71%. The learning kit fulfills the practicality requirements in large group trials with an average questionnaire of students responses of 91.99% and an average of 94.58%. Effective mathematics learning tools is to improve KPMM of students with student learning outcomes that is based on the achievement of KKM with the percentage of completeness reached is 88.24%. Development of learning tools can significantly improve students mathematical problem solving abilities at a significant level of P = 0,000 with α = 0.05. Thus, it can be concluded that the development of mathematics learning tools by applying problem based learning can improve students mathematical problem solving abilities
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Sukir, Sukir, Soenarto Soenarto, and Soeharto Soeharto. "Developing conveyor trainer kit for programmable logic controllers in practical learning." Jurnal Pendidikan Vokasi 7, no. 3 (2018): 329. http://dx.doi.org/10.21831/jpv.v7i3.15352.
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The research aims: (1) to produce conveyor trainer kit equipped with a monitoring system along with its work performance, (2) to know the appropriateness and effectiveness of the use of conveyor trainer kit and module of PLC practical learning. This study is a development research using ADDIE model based on Branch, RB. The steps of this study are: analysis, designing, developing, implementation, and evaluation. Data collection is conducted through observation, survey, and test by using the instruments: observation sheets, questionnaire, and examination. The data are analyzed descriptively using nonparametric test of difference by Mann Whitney. The finding shows: (1) the product of conveyor trainer kit equipped with monitoring system has good work performance; (2) conveyor trainer kit and the module are very appropriate, and the implementation of conveyor trainer kit and module of PLC practical learning can improve student learning outcomes in cognitive, psychomotor, and affective aspects effectively.
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Liu, Lian, Singareddy Rajareddy, Pradeep Reddy, et al. "Phosphorylation and inactivation of glycogen synthase kinase-3 by soluble kit ligand in mouse oocytes during early follicular development." Journal of Molecular Endocrinology 38, no. 1 (2007): 137–46. http://dx.doi.org/10.1677/jme.1.02027.
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Communication between mammalian oocytes and their surrounding granulosa cells through the Kit–Kit ligand (KL, or stem cell factor, SCF) system has been shown to be crucial for follicular development. Our previous studies (Reddy et al. 2005, Liu et al. 2006) have indicated that the intra-oocyte KL–Kit–PI3 kinase (PI3K)–Akt–Foxo3a cascade may play an important role in follicular activation and early development. In the present study, using in situ hybridization and in vitro culture of growing oocytes from 8-day-old postnatal mice, we have demonstrated that another Akt substrate, glycogen synthase kinase-3 (GSK-3), is expressed in growing oocytes. Also, treatment of cultured mouse oocytes with soluble KL not only leads to increased Akt kinase activity in the oocytes, which can phosphorylate recombinant GSK-3 in vitro, but also leads to phosphorylation of oocyte GSK-3α and GSK-3β, which can result in the inactivation of GSK-3 function in oocytes. In addition, we have shown that the regulation of GSK-3α and GSK-3β in cultured oocytes by soluble KL is accomplished through PI3K, since the PI3K-specific inhibitor LY294002 completely abolished the KL-induced phosphorylation of GSK-3α and GSK-3β. Moreover, blockage of the Kit signaling pathway by a Kit function-blocking antibody, ACK2, resulted in reduced phosphorylation of GSK-3. Taken together, our data suggest that the cascade from granulosa cell-derived KL to Kit–PI3K–Akt–GSK-3 in oocytes may take part in regulation of oocyte growth and early ovarian follicular development.
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Samsudin, Nurul Haniza, Puteri Roslina Abdul Wahid, and Salinah Ja’afar. "Pengaplikasian Model Awal Kit Asas Membaca Dalam Pembelajaran Bahasa Melayu Kanak-Kanak Pemulihan Khas." Sains Insani 3, no. 1 (2018): 1–9. http://dx.doi.org/10.33102/sainsinsani.vol3no1.17.
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This article discusses the application of Basic Reading Kit early model in the learning of Malay Language among remedial education children. The developed early model was related to letter recognition and graphical knowledge. The development of this Basic Reading Kit early model involved four phases namely selection, development, execution, and adaptation of which these phases were applied throughout a month-long pilot test. This research used both quantitative and qualitative approaches in collecting the data. The subjects selected were five year three students who were undergoing remedial education class in Johor Bahru, Johor. The instruments utilized in this research included both verbal and non-verbal tests. Two types of test were administered – before and after the Basic Reading Kit early model had been exposed to the children. The data illustrate that there was an increment of 3.17% in the children’s performance after the teaching and learning using the Basic Reading Kit early model (when the three learning outcomes [LO] be summed up). Even though there was no percentage increase seen in LO 2, LO 1 shows an increment of 1.54%, while in LO 3, the increase was 7.5 % as compared to the test result before the application of Basic Reading Kit early model. The data portrays the effectiveness of the application of Basic Reading Kit early model in the teaching and learning of reading among remedial education children.Keywords: early model, Basic Reading Kit, remedial education children, pilot test, learning outcomes
 ABSTRAK: Makalah ini membicarakan tentang pengaplikasian model awal Kit Asas Membaca dalam pembelajaran bahasa Melayu kanak-kanak pemulihan khas. Model awal yang dibina adalah berkaitan dengan pengecaman huruf dan pengetahuan grafik. Pembinaan model awal Kit Asas Membaca ini melibatkan empat tahap, iaitu penentuan, pembangunan, penggunaan, dan penyesuaian yang diaplikasikan melalui kajian rintis selama sebulan. Kajian ini juga menggunakan kaedah kuantitatif dan kualitatif dalam pengumpulan data. Subjek yang dipilih merupakan lima orang pelajar darjah tiga yang mengikuti kelas pemulihan khas di Johor Bahru, Johor. Instrumen yang digunakan ialah ujian lisan dan bukan lisan. Dua jenis ujian dijalankan, iaitu sebelum dan selepas penggunaan model awal Kit Asas Membaca didedahkan kepada mereka. Dapatan kajian ini menunjukkan bahawa terdapatnya peningkatan pencapaian sebanyak 3.17 % selepas pengajaran dan pembelajaran (P&P) menggunakan model awal Kit Asas Membaca apabila ketiga-tiga hasil pembelajaran (HP) dijumlahkan. Dapatan HP 1 menunjukkan wujudnya peningkatan sebanyak 1.54%, manakala HP 3 pula sebanyak 7.5% sebelum dan selepas P&P menggunakan model awal Kit Asas Membaca. Walau bagaimanapun, tiada peningkatan peratusan pencapaian bagi HP 2 sebelum dan selepas P&P menggunakan model awal Kit Asas Membaca. Dapatan ini menunjukkan bahawa terdapatnya keberkesanan pengaplikasian model awal Kit Asas Membaca sebelum dan selepas P&P membaca kepada kanak-kanak pemulihan khas.Kata kunci: model awal, Kit Asas Membaca, kanak-kanak pemulihan khas, kajian rintis, hasil pembelajaran
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Shen, Jian, Jun Shen, Chin-Feng Lai, Qi Liu, and Tianqi Zhou. "Cloud Based Data Protection in Anonymously Controlled SDN." Security and Communication Networks 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/9845426.
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Nowadays, Software Defined Network (SDN) develops rapidly for its novel structure which separates the control plane and the data plane of network devices. Many researchers devoted themselves to the study of such a special network. However, some limitations restrict the development of SDN. On the one hand, the single controller in the conventional model bears all threats, and the corruption of it will result in network paralysis. On the other hand, the data will be increasing more in SDN switches in the data plane, while the storage space of these switches is limited. In order to solve the mentioned issues, we propose two corresponding protocols in this paper. Specifically, one is an anonymous protocol in the control plane, and the other is a verifiable outsourcing protocol in the data plane. The evaluation indicates that our protocol is correct, secure, and efficient.
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Huang, Yu, Jian Yong Wang, Xiao Mei Wei, and Bin Hu. "Bioinfo-Kit: A Sharing Software Tool for Bioinformatics." Applied Mechanics and Materials 472 (January 2014): 466–69. http://dx.doi.org/10.4028/www.scientific.net/amm.472.466.
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In bioinformatics research, for the lacks of an effective algorithm-integrating mechanism and a friendly graphical user interface of the toolkits in the field of biological data processing and analyzing, the authors designed and implemented a sharing software system Bioinfo-Kit based on the Java 2 Platform Enterprise Edition (J2EE), which provides 1) a general application development interface to integrate or bridge other programs and 2) a workflow mechanism to operate them and make them talk easily. In addition, a module for biological data (multiple electrodes data, biomedical data and etc.) analysis was implemented in the software system, which provided a workflow mechanism to integrate a series of algorithms and visualization tools. Because the interface developed is very general and flexible, new analysis tools can be integrated effectively as required. Bioinfo-Kit implies an ideal environment for integrative bioinformatics research.
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Yasuhara, Yukio, Naohisa Sakamoto, Yasuo Ebara, Hiroshi Katao, and Koji Koyamada. "Development of support system for estimation of earthquake fault plane with hypocenter data." Journal of Advanced Simulation in Science and Engineering 4, no. 1 (2018): 132–42. http://dx.doi.org/10.15748/jasse.4.132.
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Yamamoto, Ryo, Yohei Morita, Hideo Ema, et al. "Megakaryocyte Lineage Commitment in Hematopoietic Stem Cells." Blood 118, no. 21 (2011): 909. http://dx.doi.org/10.1182/blood.v118.21.909.909.
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Abstract Abstract 909 Hematopoietic stem cells (HSCs) are able to self-renew and differentiate into all blood lineages. Lineage commitment can take place at any stage from daughter cells of HSCs to multipotent progenitors. We have previously suggested that lineage commitment takes place at the level of HSCs (Takano et al. 2004). According to our asymmetric model, one HSC gives rise to two daughter cells consisting of one HSC and one lineage-committed progenitor. To verify this model, we performed a series of single-cell transplantation, followed by paired daughter cell experiments. The Ly5 congenic system has been commonly used to distinguish test donor cells from recipient cells and competitor cells. Since the Ly5 antigen is only expressed in leukocytes, platelets and erythrocytes have not been examined for evaluation of multi-lineage reconstitution. To assess lineage contribution more precisely, we have recently generated a transgenic mouse line in which Kusabira Orange (KuO) is expressed in all blood lineages including platelets and erythrocytes. CD150+CD41−CD34−/lowc-Kit+Sca-1+Lin− (CD150+CD41−CD34−KSL) cells, in which HSCs are highly enriched (Kiel et al. 2005, Morita et al. 2010), and CD150−CD41−CD34−KSL cells were individually isolated from KuO transgenic mice (B6-Ly5.1), and were transplanted into lethally irradiated mice (B6-Ly5.2), along with 2×105 bone marrow cells (B6-Ly5.1/Ly5.2). For secondary transplantation, 1×107 bone marrow cells from recipient mice were transplanted to lethally irradiated mice. Peripheral blood cells of primary and secondary recipient mice were periodically analyzed after transplantation. In some mice, full-lineage reconstitution was detected after transplantation with single CD150+CD41−CD34−KSL cells. In others, only common myeloid progenitor-type reconstitution was detected whereas common lymphoid progenitor-type reconstitution was not detected at all. Interestingly, megakaryocyte lineage (Meg)-restricted reconstitution and Meg/erythrocyte lineage-restricted (ME) reconstitution were observed after transplantation with single CD150+CD41−CD34−KSL cells, but not after transplantation with single CD150−CD41−CD34−KSL cells. These results suggest that Meg and ME progenitors are closely related to HSCs in their development. Furthermore, we performed paired daughter cell assays combined with single cell transplantation. Following division of CD150+CD41−CD34−KSL cells in culture, individual two daughter cells were separated by micromanipulation techniques and were transplanted into lethally irradiated mice with 2 × 105 competitor cells. Preliminary data showed in effect that the recipient mice of each single daughter cell derived from one CD150+CD41−CD34−KSL cell exhibited asymmetric differentiation; one with full-lineage reconstitution and the other with Meg-restricted reconstitution. Our findings offer a new perspective of HSC differentiation pathways. Disclosures: No relevant conflicts of interest to declare.
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Kanamura, Momomi, Kanata Suzuki, Yuki Suga, and Tetsuya Ogata. "Development of a Basic Educational Kit for Robotic System with Deep Neural Networks." Sensors 21, no. 11 (2021): 3804. http://dx.doi.org/10.3390/s21113804.
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In many robotics studies, deep neural networks (DNNs) are being actively studied due to their good performance. However, existing robotic techniques and DNNs have not been systematically integrated, and packages for beginners are yet to be developed. In this study, we proposed a basic educational kit for robotic system development with DNNs. Our goal was to educate beginners in both robotics and machine learning, especially the use of DNNs. Initially, we required the kit to (1) be easy to understand, (2) employ experience-based learning, and (3) be applicable in many areas. To clarify the learning objectives and important parts of the basic educational kit, we analyzed the research and development (R&D) of DNNs and divided the process into three steps of data collection (DC), machine learning (ML), and task execution (TE). These steps were configured under a hierarchical system flow with the ability to be executed individually at the development stage. To evaluate the practicality of the proposed system flow, we implemented it for a physical robotic grasping system using robotics middleware. We also demonstrated that the proposed system can be effectively applied to other hardware, sensor inputs, and robot tasks.
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Ito, Takayoshi, Takeshi Nakatani, Stefanus Harjo, et al. "Application Software Development for the Engineering Materials Diffractometer, TAKUMI." Materials Science Forum 652 (May 2010): 238–42. http://dx.doi.org/10.4028/www.scientific.net/msf.652.238.
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The Engineering Materials Diffractometer Application Kit called EMAKi has been developed to control the Engineering Materials Diffractometer, TAKUMI, and treat data obtained by it. It is expected that TAKUMI will be widely used by not only academic users but also industrial users. We have designed EMAKi to be user-friendly interface for novice users by graphical user interface (GUI). In addition, adopting Python programming language for its development has enabled advanced users to control the diffractometer flexibly and treat the data easily. During instrumentation commissioning and running user programs, the software has demonstrated useful.
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Bjärkefur, Kristoffer, Luíza Cardoso de Andrade, and Benjamin Daniels. "iefieldkit: Commands for primary data collection and cleaning." Stata Journal: Promoting communications on statistics and Stata 20, no. 4 (2020): 892–915. http://dx.doi.org/10.1177/1536867x20976321.
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Data collection and cleaning workflows implement highly repetitive but extremely important processes. In this article, we introduce iefieldkit, a package developed to standardize and simplify best practices for high-quality primary data collection across the World Bank’s Development Research Group Impact Evaluations department. iefieldkit automates error-checking for electronic Open Data Kit-based survey modules such as those implemented in SurveyCTO; duplicate checking and resolution; data cleaning, including renaming, labeling, recoding, and survey harmonization; and codebook creation.
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Naf'an, Muhammad Kholish, Kurniasih Kurniasih, Tri Untari, and Yos Adi Prakoso. "Development of a coagglutination kit as a rapid test for diagnosing Newcastle disease in poultry." August-2020 13, no. 8 (2020): 1719–24. http://dx.doi.org/10.14202/vetworld.2020.1719-1724.
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Background and Aim: Newcastle disease (ND) is a viral infection that causes high mortality and economic loss in the poultry industry. The Office International des Epizooties (OIE) recommends several diagnostic methods for the detection of ND, including isolation and molecular tests. However, these detection methods are time-consuming and highly expensive. Therefore, this study was conducted to develop a coagglutination kit as a novel diagnostic tool for ND in the poultry industry. Materials and Methods: Two adult male New Zealand White rabbits weighing 2.5 kg were vaccinated using ND life vaccine intraperitoneally. The vaccination was conducted once a week for 4 weeks with multilevel doses. Rabbits' serum was collected at week 6 and inactivated at 56°C for 30 min. The serum was precipitated using ammonium sulfate and reacted with protein A of Staphylococcus aureus to produce the agglutination kit for detecting ND virus. A total of 25 chickens suspected with ND infection from a local poultry farm in Yogyakarta were used as the test samples. The chickens were necropsied, and the brain, spleen, lung, intestine, and feces were collected. Half of these organs were subjected to tests using the coagglutination kit and reverse transcription-polymerase chain reaction (RT-PCR). The other half was processed for histopathology. Data were analyzed qualitatively. Results: Of the 25 samples, 13 (52%) were positive for ND infection when tested using both the ND coagglutination kit and RT-PCR. The positive samples also exhibited several histopathological changes, including perivascular cuffing surrounding the cerebral blood-brain barrier, hemorrhagic pneumonia, splenitis, and necrotic hemorrhage enteritis. Conclusion: This study confirmed that the ND coagglutination kit could be used as a novel diagnostic tool for the detection of ND virus infection in the poultry industry.
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Melzer, Jonathan M., Erin R. S. Hamersley, and Thomas Q. Gallagher. "Use of a Novel Airway Kit and Simulation in Resident Training on Emergent Pediatric Airways." Otolaryngology–Head and Neck Surgery 156, no. 6 (2017): 1048–53. http://dx.doi.org/10.1177/0194599817697046.
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Objective Development of a novel pediatric airway kit and implementation with simulation to improve resident response to emergencies with the goal of improving patient safety. Methods Prospective study with 9 otolaryngology residents (postgraduate years 1-5) from our tertiary care institution. Nine simulated pediatric emergency airway drills were carried out with the existing system and a novel portable airway kit. Response times and time to successful airway control were noted with both the extant airway system and the new handheld kit. Results were analyzed to ensure parametric data and compared with t tests. A Bonferroni adjustment indicated that an alpha of 0.025 was needed for significance. Results Use of the airway kit significantly reduced the mean time of resident arrival by 47% ( P = .013) and mean time of successful intubation by 50% ( P = .007). Survey data indicated 100% improved resident comfort with emergent airway scenarios with use of the kit. Discussion Times to response and meaningful intervention were significantly reduced with implementation of the handheld airway kit. Use of simulation training to implement the new kit improved residents’ comfort and airway skills. This study describes an affordable novel mobile airway kit and demonstrates its ability to improve response times. Implications for Practice The low cost of this airway kit makes it a tenable option even for smaller hospitals. Simulation provides a safe and effective way to familiarize oneself with novel equipment, and, when possible, realistic emergent airway simulations should be used to improve provider performance.
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Spanel-Borowski, Katharina, Kristina Sass, Sabine Löffler, Elke Brylla, Michiharu Sakurai, and Albert M. Ricken. "KIT receptor-positive cells in the bovine corpus luteum are primarily theca-derived small luteal cells." Reproduction 134, no. 4 (2007): 625–34. http://dx.doi.org/10.1530/rep-07-0236.
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The tyrosine kinase KIT receptor, the protooncogene CD117, plays a key role in growth and maturation of oocytes and follicles. Relevant data are sparse for the corpus luteum (CL). We first confirmed the presence ofKITmRNA and KIT protein in bovine CL homogenates. We then localized KIT-positive (KIT+) cells in CL sections by immunohistochemistry. At the CL stage of early development, the former theca transforming into capsule/septa showed a strong band-like KIT+ immunoresponse. In addition, CD45+ leukocytes in septa included subpopulations of CD45+/KIT+ and CD14+/KIT+ leukocytes as validated by double immunofluorescence localization. At the early secretory stage, KIT+ cells appeared within the septa/capsule region and in the periphery of the CL parenchyma, there forming a complex network. This was separate from the capillary bed as determined by double staining for CD117 and FVIII-related endothelial cell antigen (FVIIIr). The KIT+ network coincided with cells positive for cytochrome P450 17α-hydroxylase, a thecal cell-specific enzyme. The late secretory stage was defined by an advanced manifestation of the KIT+ network in the CL periphery. At the stage of regression, the KIT+ network was absent. The CL of pregnancy expressed high levels ofKITmRNA and KIT protein uniformly throughout pregnancy. The KIT+ immunolocalization revealed small fibroblast-like cells, luteal cells with granules, and clusters of large luteal cells with staining of the cell membrane. We conclude that a majority of KIT+ cells in the bovine CL are primarily theca-derived small luteal cells, and that a minority represent KIT+ leukocytes, in some cases KIT+ monocytes.
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Zhang, Ming Hui, and Yao Yu Zhang. "Development of Timing Component for Angular Distortion Measurement System." Applied Mechanics and Materials 397-400 (September 2013): 1759–62. http://dx.doi.org/10.4028/www.scientific.net/amm.397-400.1759.
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A timing component is developed in order to achieve the synchronization between measuring system and external devices. The function of timing system, as well as the data switching driver based on twin port RAM and interrupt response driver developed by using DDK (Driver Development Kit), are introduced in this paper. The timing component has been used to ensure the synchronization between measurement system and vessel devices, and successfully applied in angular distortion measurement systems.
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Mustrifarini, Ary. "PENGEMBANGAN PERANGKAT PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE DENGAN MENGGUNAKAN TEKNIK MIND MAP PADA MATA PELAJARAN PKN DI KELAS IV SEKOLAH DASAR." Jurnal Review Pendidikan Dasar : Jurnal Kajian Pendidikan dan Hasil Penelitian 3, no. 3 (2017): 517. http://dx.doi.org/10.26740/jrpd.v3n3.p517-526.
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ABSTRACTThis research is aimed to describe the feasibility, practicity, and effectiveness of the development of learning cooperative equipment type think pair share by using mind mapp technique of civic lesson for the Fourth Grade Students Elementary School. In this research, the learning equipment that is developed : Lesson Plan, Student Worksheet, and Test. This research uses theory of the development of 4-D models of Thiagarajan (1974) consisting of four stages: (a) define, (b) design, (c) develop and (d) disseminate. But the disseminate is not did because of the limitation of finance, energy, time, and experience and the result of research is only done at SD Muhammadiyah Madiun city as the place of the research. The research is only until develop step to 0,99 in the category of goodof learning isn 99,7%, this means that teachers can implement the learning in conformity with the pla. Moeover, it is also practical based on research that shows 97,1% the student actively in learning, give positive response and unterested in participating in learning as much as 100%, and the result of Achievment Test is93,8% due KKM. Baed on the analysis above, it can be concluded that the type cooperative learning Think Pair Share at Civic Lesson on the fourth grade of Elementary School is feasible, practical, and effective to use, but it still require an adjustment to the situation and condition of each school. Keywords: Kit Media, Science Learning, Scientific, dan Mastery of Concept. ABSTRAKPenelitian ini bertujuan mendeskripsikan kelayakan, kepraktisan, dan keefektifan pengembangan perangkat pembelajaran kooperatif tipe think pair share dengan menggunakan teknik mind map pada mata pelajaran PKn di kelas IV Sekolah Dasar. Dalam penelitian ini, perangkat pembelajaran yang dikembangkan antara lain : Rencana Pelaksanaan Pembelajaran (RPP), Lembar Kerja Siswa (LKS), dan Tes Hasil Belajar (THB). Tahap-tahap penelitian pengembangan perangkat pembelajaran ini menggunakan model 4-D (four-d model) dari Thiagarajan, Semmei dan Semmel (1975). Model 4-D terdiri dari tahap pendefinisian (define), tahap perancangan (design), tahap pengembangan (develop), dan tahap penyebaran (disseminate). Dikarenakan keterbatasan biaya, tenaga, waktu dan kesempatan maka pendesiminasian tidak dilakukan. Hasil penelitian hanya diterapkan di tempat penelitian, yaitu di SD Muhammadiyah Kota Madiun. Maka dalam rancangan penelitian ini, pengembangan perangkat pembelajaran hanya sampai pada tahap ketiga yaitu tahap pengembangan (develop). Data hasil penelitian diperoleh sebagai berikut: keseluruhan validasi diperoleh rata-rata skor 3,55 dengan realibilitas 0,99 dalam kategori baik, pembelajaran ini juga praktis berdasarkan keterlaksanaan pembelajaran sebesar 99,7% ini artinya guru dapat melaksanakan pembelajaran sesuia dengan rencana. Selain itu, perangkat pembelajaran ini juga praktis berdasarkan hasil penelitian yang menunjukkan 97,1% siswa aktif dalam pembelajaran, respon positif siswa dan berminat mengikuti pembelajaran seperti sebesar 100%, dan hasil THB 93,8% tuntas mencapai KKM. Berdasarkan hasil analisa diatas, dapat disimpulkan bahwa perangkat pembelajaran kooperatif tipe Think Pair Share layak, praktis, dan efektif untuk digunakan, namun masih memerlukan penyesuaian dengan situasi dan kondisi di sekolah masing-masing. Kata Kunci: Pengembangan perangkat, pembelajaran kooperatif, pembelajaran kooperatif tipe think pair share, teknik mind map.
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Pantilimonescu, Florin, Lucian Constantin Hanganu, Mihaita Peptanariu, et al. "Modular Student Learning Kit for Internet of Things." Applied Mechanics and Materials 659 (October 2014): 601–6. http://dx.doi.org/10.4028/www.scientific.net/amm.659.601.
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The term Internet of Things as a component of Future Internet is a recent fast growing global network infrastructure which extends Internet with a sensors and actuators shield. The paper presents a hands-on learning kit based on an open standard embedded computer connected to Internet enabling live data processing. The system uses cloud programming tools to add significant value to the education purpose, by including up-to-date innovative technical approaches and pedagogical values for improving the attractiveness and efficiency of the education activities in the engineering area. The learning goal intends to develop the Internet of things as new universe based on smart objects, connected to the Internet via adequate sensors and actuators. This can be an essential tool for a deeper understanding of the main concepts in physics, informatics and math, even in the early steps of learning. Based on cloud programming resources, the hardware-software components use the latest version of low power 32-bit embedded computer development platform and process interfaces to allow data monitoring, remote physical experiments, mobile world supervising, and collaborative project development. As an open standard learning tool, the kit offers a new computational framework able to serve in scientific experiments and discovery-based learning. This study was strongly motivated by the European Union recommendation to support and enrich the university curriculum by engaging students in hands-on engineering and design activities.
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Paz-Carreira, Jose M., Raquel Losada, Arantxa Garcia-Rivero, Augusto Alvarez, Fernando Bal, and Jesus Alba. "Promoter Methylation of Multiple Genes in Germinal Center Hyperplasia and Lymphomas of Germinal Center Origin." Blood 112, no. 11 (2008): 4487. http://dx.doi.org/10.1182/blood.v112.11.4487.4487.
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Abstract INTRODUCTION. Germinal centers (GC) are unique sites in peripheral lymphoid tissue where clonal selection of B cells takes place. This occurs as a response to stimulation by various antigens originating, sometimes, follicular hyperplasia (FH). GC have been known as a major source of B-cell lymphomas including follicular (FL) and diffuse large cell (DLCL). DNA methylation of tumor-suppressor genes is a mechanism of gene silencing involved in the pathogenesis of FL and DLCL. Much less is known about the role of methylation in FH. We determined the methylation status of 6 tumor-suppressor genes in 43 patients with FH, 18 patients with FL and 49 patients with DLCL in order to see the differential implication of this epigenetic mechanism in the pathological and the physiological development of GC. MATERIAL AND METHODS. Genomic DNA extracted from paraffin-embedded samples of 43 FH, 18 FL and 49 DLCL after being treated with EZ DNA-Methylation Kit (Zymo Research) with the manufacturer’s instructions, were analyzed by methylation-specific polymerase chain-reaction to determine promoter hypermethylation of DAP-k, SHP1, Rarβ, p14, SHP1, MGMT and PDRM1. All samples were obtained mostly from lymph nodes and tonsils. Diagnosis was based on morphology and immunohistochemistry analysis. All cases were matched for age, sex and ethnic origin. RESULTS: DAP-k promoter methylation occurred with higher frequency in FL(89%) than in DLCL(78%) and FH(40%). SHP1 was methylated in 61% of FL, 58% of FH and 23% of DLCL. RARb was methylated in 67% of FL patients, 30% of DLCL and only 12% of FH. Eight (44%) FL, seventeen (35%) DLCL and four (10%) BFH patients showed MGMT methylation. Promoter hypermethylation of p14 was detected only in 5 (12%) FH, 2 (4%) DLCL and none FL patients. Methylation of PRMD1 was present only in 1 (6%) FL, 2 (6%) DLCL and 1 (4%) FH samples. CONCLUSIONS. Inactivacion of DAP-K and SHP1 is present in B-cell malignancies, DLCL and FL, and BFH. Therefore, it may represent a physiologic event conferring a temporal survival advantage necessary for a GC hyperplastic response. Inactivation of the retinoic acid response through the methylation of Rarâ is significantly more frequent in lymphomas than in FH. As reported in other tumors methylation of MGMT is more frequent in lymphomas than in FH. With our data methylation of Cyclin dependent kinase inhibitors p14 is not a differential pathogenic event in lymphomas of GC origin, in fact it is more frequent in FH. Promoter Methylation of PDRM1 is not the mechanism involved in lymphomagenesis in FL and DLCL, the two FH positive deserve further follow-up to determine its significance.
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Dasopang, Khuzaimah, and Iis Siti Jahro. "Pengembangan KIT Pembelajaran Dari Limbah Pada Materi Ikatan Kimia Untuk Meningkatkan Hasil Belajar Siswa." Jurnal Inovasi Pembelajaran Kimia 2, no. 2 (2020): 116. http://dx.doi.org/10.24114/jipk.v2i2.19816.
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The research with the title Development of Chemical Learning KIT from Waste on Chemical Bonding Materials to Improve Student Learning Outcomes in Class X high school aims to find out whether the KIT created can meet the eligibility standards of a KIT and can improve student learning outcomes. The population in this study were all students of class X SMA Budisatrya Medan. The sample used in this study was taken by purposive sampling of one class, namely class X MIA 1 as an experimental class that was taught using KIT learning media. The test instruments used in this study were 20 questions that have been tested valid. Based on the results of data analysis, the KIT Learning media made have met the eligibility standard and in the hypothesis test the data obtained from the calculation table obtained tcount= 13.90 while at 1.696 ttable, so the tcount is higher than the ttable value (tcount>ttable) then Ho rejected and Ha accepted so it can be concluded that the average chemistry learning outcomes of students taught using the Chemical Bond KIT learning media are made higher than the KKM value (by 70) ie the average posttest score of students is 84.29.
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Subkan. "Media Innovation Based on Simple Kit for Dynamic Electricity Learning." Studies in Learning and Teaching 1, no. 3 (2020): 209–17. http://dx.doi.org/10.46627/silet.v1i3.44.
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This study aims to determine the effectiveness of simple KIT-based media in improving student learning achievement in dynamic electricity material. The sample used was the students of class grade 12 of IPA-3 Madrasah Aliyah Negeri 2 Mojokerto, totaling 35 students. The type of research used is research development (Research and Development). The research data were obtained from questionnaire responses during learning and the results of the pre-test and post-test. The questionnaire's responses were as many as 85.14% of students who thought that the development of KIT-based learning media was very effective in using dynamic electricity learning. Moreover, as many as 14.85% think that KIT-based learning media is creative and interactive learning and is an additional supplement in the teaching and learning process. From the test results given to students, there was a significant increase in students' achievements. This indicator can be seen from the t count value is smaller than the t table (t count <t table), then H1 (learning with media treatment) can be applied in learning. Another indicator is that the value of p-value is smaller than alpha 5% (0.05) Ho (learning without treatment) is rejected, so it is concluded that there is a significant increase between learning outcomes before using Simple KIT-based media after implementing learning media using simple KIT
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Suyatman, Suyatman. "Analisis Kebutuhan Pengembangan Laboratorium PGMI dalam Perkuliahan IPA." At-Tarbawi: Jurnal Kajian Kependidikan Islam 1, no. 1 (2016): 57. http://dx.doi.org/10.22515/attarbawi.v1i1.35.
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Based on documentation of pgmi mentioned that college students are derived from background science class is 36,98 % , less than 50 % of the student PGMI .This has led consequence that lecture believe in science ranging from the base and supported by the laboratory adequate .The laboratory adequate will build real kosep students in understand science.Steps analysis needs research laboratory PGMI in lecture ipa is as follows: 1) analysis of need assessment, 2) the literature study, 3) study komparasi , 4) expert judgment, 5) improvement. Based on analysis of the data can pull conclusions as follows: 1) The lab PGMI FITK IAIN Surakarta especially for science laboratory having 85 set equipment consisting of 737 the tools and can be used to 121 title science experiments. 2) Additional needs necessary the 25 set equipment science experiments, with details as follows: kit science less 24 set, consisting of the balance KIT 4 sets, mineral KIT 5 sets, Sound KIT 4 sets, coal KIT 6 sets, and heat engine KIT 5 sets, and science integrated KIT less 1 set, and 5 the microscopes.Keywords: analysis needs , the development of a laboratory, IPA lecture
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Abd Rahman, N. H., M. T. Islam, N. Misran, Y. Yamada, and N. Michishita. "Development of Ray Tracing Algorithms for Scanning Plane and Transverse Plane Analysis for Satellite Multibeam Application." International Journal of Antennas and Propagation 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/812461.
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Reflector antennas have been widely used in many areas. In the implementation of parabolic reflector antenna for broadcasting satellite applications, it is essential for the spacecraft antenna to provide precise contoured beam to effectively serve the required region. For this purpose, combinations of more than one beam are required. Therefore, a tool utilizing ray tracing method is developed to calculate precise off-axis beams for multibeam antenna system. In the multibeam system, each beam will be fed from different feed positions to allow the main beam to be radiated at the exact direction on the coverage area. Thus, detailed study on caustics of a parabolic reflector antenna is performed and presented in this paper, which is to investigate the behaviour of the rays and its relation to various antenna parameters. In order to produce accurate data for the analysis, the caustic behaviours are investigated in two distinctive modes: scanning plane and transverse plane. This paper presents the detailed discussions on the derivation of the ray tracing algorithms, the establishment of the equations of caustic loci, and the verification of the method through calculation of radiation pattern.
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Nawrocki, Tomasz, and Krzysztof Bierwiaczonek. "Praca w pamięci zbiorowej mieszkańców górnośląskiej wsi na tle procesów przemian obszarów wiejskich." Kultura i Społeczeństwo 64, no. 1 (2020): 197–221. http://dx.doi.org/10.35757/kis.2020.64.1.9.
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The subject of the article is collective memory of the concept of work among the inhabitants of the Upper Silesian village of Bojszowy. The author of the study employs the classic understanding of collective memory, while simultaneously pointing to the importance of the communication process and the diversity of information sources shaping it. Empirical data was collected during research conducted in 2018 using in-depth interview techniques. The research sample consisted of 30 rural residents. Analysis of the functioning of collective memory about work revealed the development processes – especially industrialization and deagrarianization – taking place in Bojszów. The analysis clearly shows the specificity of the Upper Silesian village, where these processes began relatively early, and work was associated not only with agriculture, but also with industry and trade.