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Journal articles on the topic "David Hume Institute"
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Castro Chavarría, Hazel. "La noción de “cúmulo (congeries) de percepciones” en los Comentarios filosóficos de George Berkeley [The notion of ‘congeries (cúmulo) de percepciones’ in the Philosophical Commentaries of George Berkeley]." LOGOS Revista de Filosofía 135, no. 135 (2020): 55–65. http://dx.doi.org/10.26457/lrf.v135i135.2717.
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Durante la época moderna predominó la idea de que no podíamos explicar la ejecución de nuestros actos mentales sin admitir la existencia de un sujeto que llevara a cabo dicha actividad. Esto último repercutió de manera importante en la aceptación de la propuesta que en el Tratado de la naturaleza humana David Hume hiciera en torno al ‘yo’; que éste consistía únicamente en ser un haz de percepciones. Sin embargo, esta concepción no era nueva. Ya en los Comentarios filosóficos de George Berkeley encontramos vestigios de una noción similar. Esta concepción, como observaremos, dejaría fuera cualquier representación de la mente en términos de una entidad independiente de nuestras percepciones que, además, ejecutaría las actividades propias de una vida mental. Finalmente, el eje de esta breve investigación girará en torno al supuesto de que no habría una sustancia espiritual individual distinta a un conjunto (haz/cúmulo) de percepciones.
 Palabras clave
 Actos mentales; Yo; Entidad independiente; Sustancia espiritual individual; Haz/Cúmulo de percepciones
 
 Referencias
 Berkeley, George. Comentarios filosóficos. Introducción manuscrita a los Principios del conocimiento humano. Correspondencia con Johnson. Traducido por José Antonio Robles. México: Instituto de Investigaciones Filosóficas-UNAM, 1989.
 _____________________ Tratado sobre los principios del conocimiento humano. Traducido por Carlos Mellizo. Madrid: Alianza, 2014.
 Castro, Hazel. “La idea de una ‘mente singular’ en Hume: el ‘qué o quién’ ejecuta las actividades propias de una vida mental”, en Laura Benítez y Luis RamosAlarcón (coords.), El concepto de sustancia de Spinoza a Hegel, UNAM, 2018.
 Descartes, René. Meditaciones metafísicas y otros textos. Traducido por E. López y M. Graña. Madrid: Gredos, 1997.
 Hume, David. Tratado de la naturaleza humana. Traducido por Félix Duque. Madrid: Tecnos, 1988. Locke, John. Ensayo sobre el entendimiento humano. Traducido por E. O’Gorman. México: Fondo de cultura económica, 2005.
 Mellizo, Carlos. En torno a David Hume: Tres estudios de aproximación. Zamora: Ediciones Monte Casino, 1978.
 Olson, Eric T., “Personal Identity”, The Stanford Encyclopedia of Philosophy (Fall 2019 Edition), Edward N. Zalta (ed.), URL = 
 Robles, José Antonio.“Génesis de la noción de sustancia desde George Berkeley I.” Diánoia, Vol. 30, no. 30, 1984.
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Tomlinson, Roy, Gerald Mills, Mark Hennessy, and Arnold Horner. "Reviews of Books." Irish Geography 30, no. 2 (2015): 113–18. http://dx.doi.org/10.55650/igj.1997.388.
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GLOBAL CHANGE AND THE IRISH ENVIRONMENT, edited by John Sweeney. Dublin: Royal Irish Academy and Irish Committee for International Geosphere-Biosphere Programme, 1997. 170pp. IR£10.00pb. ISBN 1 874045 50 X. Reviewed by ROY TOMLINSONCLIMATES OF THE BRITISH ISLES: PRESENT, PAST AND FUTURE, edited by Mike Hulme and Elaine Barrow. London: Routledge, 1997. 439pp. £17.99stg. ISBNO- 415-13017-4(pb). REGIONAL CLIMATES OF THE BRITISH ISLES, edited by Dennis Wheeler and Julian Mayes. London: Routledge, 1997. 343pp. £17.99stg. ISBN 0-415- 13931-7 (pb). Reviewed by GERALD MILLSPROPERTY OWNERSHIP AND URBAN AND VILLAGE IMPROVEMENT IN PROVINCIAL IRELAND c. 1700-1845, by Lindsay Proudfoot. [British] Historical Geography Research Group, Historical Geography Research Series, No.33,1997. 105pp. £7.95stg. ISBN I 87007415 7. Reviewed by MARK HENNESSYDOWNPATRICK, by Ronald Buchanan and Anthony Wilson. Fascicle No.8, Irish Historic Towns Atlas, edited by A. Simms, H.B. Clarke and R. Gillespie. Dublin: Royal Irish Academy, 1997. 16pp. text+ 8 maps+2 plates. IR£18.00. ISBN 0-874045-33-X. Reviewed by MARK HENNESSYTHEM AND US?: ATTITUDINAL VARIATION AMONG CHURCHGOERS IN BELFAST, by Frederick W. Boal, Margaret C. Keane and David N. Livingstone. Belfast: Institute of Irish Studies, Insight Series No.l, 1997. 240pp. ISBN 0-85389- 679-8. Reviewed by ARNOLD HORNER
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KITLV, Redactie. "Book reviews." New West Indian Guide / Nieuwe West-Indische Gids 66, no. 3-4 (1992): 249–318. http://dx.doi.org/10.1163/13822373-90002001.
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-Jay B. Haviser, Jerald T. Milanich ,First encounters: Spanish explorations in the Caribbean and the United States, 1492-1570. Gainesville FL: Florida Museum of Natural History & University Presses of Florida, 1989. 221 pp., Susan Milbrath (eds)-Marvin Lunenfeld, The Libro de las profecías of Christopher Columbus: an en face edition. Delano C. West & August Kling, translation and commentary. Gainesville FL: University of Florida Press, 1991. x + 274 pp.-Suzannah England, Charles R. Ewen, From Spaniard to Creole: the archaeology of cultural formation at Puerto Real, Haiti. Tuscaloosa AL; University of Alabama Press, 1991. xvi + 155 pp.-Piero Gleijeses, Bruce Palmer Jr., Intervention in the Caribbean: the Dominican crisis of 1965. Lexington KY: University Press of Kentucky, 1989.-Piero Gleijeses, Herbert G. Schoonmaker, Military crisis management: U.S. intervention in the Dominican Republic, 1965. Westport CT: Greenwood Press, 1990. 152 pp.-Jacqueline A. Braveboy-Wagner, Fitzroy André Baptiste, War, cooperation, and conflict: the European possessions in the Caribbean, 1939-1945. Westport CT: Greenwood Press, 1988. xiv + 351 pp.-Peter Meel, Paul Sutton, Europe and the Caribbean. London: Macmillan Caribbean, 1991. xii + 260 pp.-Peter Meel, Betty Secoc-Dahlberg, The Dutch Caribbean: prospects for democracy. New York: Gordon and Breach, 1990. xix + 333 pp.-Michiel Baud, Rosario Espinal, Autoritarismo y democracía en la política dominicana. San José, Costa Rica: Ediciones CAPEL, 1987. 208 pp.-A.J.G. Reinders, J.M.R. Schrils, Een democratie in gevaar: een verslag van de situatie op Curacao tot 1987. Assen, Maastricht: Van Gorcum, 1990. xii + 292 pp.-Andrés Serbin, David W. Dent, Handbook of political science research on Latin America: trends from the 1960s to the 1990s. Westport CT: Greenwood, 1990.-D. Gail Saunders, Dean W. Collinwood, The Bahamas between worlds. Decatur IL: White Sound Press, 1989. vii + 119 pp.-D. Gail Saunders, Dean W. Collinwood ,Modern Bahamian society. Parkersburg IA: Caribbean Books, 1989. 278 pp., Steve Dodge (eds)-Peter Hulme, Pierrette Frickey, Critical perspectives on Jean Rhys. Washington DC: Three Continents Press, 1990. 235 pp.-Alvina Ruprecht, Lloyd W. Brown, El Dorado and Paradise: Canada and the Caribbean in Austin Clarke's fiction. Parkersburg IA: Caribbean Books, 1989. xv + 207 pp.-Ineke Phaf, Michiel van Kempen, De Surinaamse literatuur 1970-1985: een documentatie. Paramaribo: Uitgeverij de Volksboekwinkel, 1987. 406 pp.-Genevieve Escure, Barbara Lalla ,Language in exile: three hundred years of Jamaican Creole. Tuscaloosa AL: University of Alabama Press, 1990. xvii + 253 pp., Jean D'Costa (eds)-Charles V. Carnegie, G. Llewellyn Watson, Jamaican sayings: with notes on folklore, aesthetics, and social control.Tallahassee FL: Florida A & M University Press, 1991. xvi + 292 pp.-Donald R. Hill, Kaiso, calypso music. David Rudder in conversation with John La Rose. London: New Beacon Books, 1990. 33 pp.-Mark Sebba, John Victor Singler, Pidgin and creole tense-mood-aspect systems. Amsterdam and Philadelphia: John Benjamins, 1990. xvi + 240 pp.-Dale Tomich, Pedro San Miguel, El mundo que creó el azúcar: las haciendas en Vega Baja, 1800-873. Río Piedras, Puerto Rico: Ediciones Huracán, 1989. 224 pp.-César J. Ayala, Juan José Baldrich, Sembraron la no siembra: los cosecheros de tabaco puertorriqueños frente a las corporaciones tabacaleras, 1920-1934. Río Piedras, Puerto Rico: Ediciones Huracán, 1988.-Robert Forster, Jean-Michel Deveau, La traite rochelaise. Paris: Kathala, 1990. 334 pp.-Ernst van den Boogaart, Johannes Menne Postma, The Dutch in the Atlantic slave trade, 1600-1815. Cambridge: Cambridge University Press, 1990. xiv + 428 pp.-W.E. Renkema, T. van der Lee, Plantages op Curacao en hun eigenaren (1708-1845): namen en data voornamelijk ontleend aan transportakten. Leiden, the Netherlands: Grafaria, 1989. xii + 87 pp.-Mavis C. Campbell, Wim Hoogbergen, The Boni Maroon wars in Suriname. Leiden, the Netherlands: E.J. Brill, 1990. xvii + 254 pp.-Rafael Duharte Jiménez, Carlos Esteban Dieve, Los guerrilleros negros: esclavos fugitivos y cimarrones en Santo Domingo. Santo Domingo: Fundación Cultural Dominicana, 1989. 307 pp.-Rosemarijn Hoefte, Hans Ramsoedh, Suriname 1933-1944: koloniale politiek en beleid onder Gouverneur Kielstra. Delft, the Netherlands: Eburon, 1990. 255 pp.-Gert Oostindie, Kees Lagerberg, Onvoltooid verleden: de dekolonisatie van Suriname en de Nederlandse Antillen. Tilburg, the Netherlands: Instituut voor Ontwikkelingsvraagstukken, Katholieke Universiteit Brabant, 1989. ii + 265 pp.-Aisha Khan, Anthony de Verteuil, Eight East Indian immigrants. Port of Spain: Paria, 1989. xiv + 318 pp.-John Stiles, Willie L. Baber, The economizing strategy: an application and critique. New York: Peter Lang, 1988. xiii + 232 pp.-Faye V. Harrison, M.G. Smith, Poverty in Jamaica. Kingston: Institute of social and economic research, 1989. xxii + 167 pp.-Sidney W. Mintz, Dorian Powell ,Street foods of Kingston. Mona, Jamaica: Institute of social and economic research, 1990. xii + 125 pp., Erna Brodber, Eleanor Wint (eds)-Yona Jérome, Michel S. Laguerre, Urban poverty in the Caribbean: French Martinique as a social laboratory. New York: St. Martin's Press, 1990. xiv + 181 pp.
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McGrath, Alister E. "Science and Religion: A New Introduction, 3rd ed." Perspectives on Science and Christian Faith 73, no. 1 (2021): 59–60. http://dx.doi.org/10.56315/pscf3-21mcgrath.
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SCIENCE AND RELIGION: A New Introduction, 3rd edition by Alister E. McGrath. Hoboken, NJ: John Wiley and Sons, 2020. 272 pages. Paperback; $28.99. ISBN: 9781119599876. *Alister McGrath is a major international scholar who is prolific in his output. He has produced many popular books and academic tomes, and as a theological educator his output also includes many textbooks for students. Science and Religion: A New Introduction is now into its third edition and is an excellent introduction to the whole field of science and religion. The restructuring and inclusion of new material is designed to be helpful to the student, and reflects comments on the previous editions. The book introduces most of the areas of interaction between these bodies of thought, and I myself have used earlier editions in my own teaching, giving students a chapter of McGrath to start with for an essay, followed by more detailed material from elsewhere. *McGrath notes that science and religion are wide categories and serious study entails narrowing them down. He describes Ian Barbour's four models for interaction followed by what he calls four ways of imagining the relationship between them. The conflict model is rightly dismissed as a late nineteenth-century myth, and areas where conflict has been perceived, notably with Galileo and Darwin, are given the more nuanced treatment they deserve, thus dispelling the myths surrounding them. McGrath also gives a broader historical overview, refuting the further myth that the scientific revolution owed nothing to the medieval period. He describes the development of the Newtonian mechanistic model of the universe and brings us to the twentieth century with the development of the Big Bang theory. Regarding this last, it would have been good to note the pioneering work of Roman Catholic priest Georges Lemaître, often dubbed the "Father of the Big Bang," who, in contrast to Alexander Friedman, regarded solutions of Einstein's equations as physically realistic and not just mathematical curiosities. *McGrath moves on to a helpful chapter on religion and the philosophy of science. Some form of realism seems predominant and, indeed, the most rational position to take. It is interesting to note the adoption of "critical realism," including not only by science-religion scholars such as John Polkinghorne and others, but also such as the biblical scholar N. T. Wright and James Dunn. McGrath moves on to the role of explanation in science, noting how in science there are different methods for different sciences, and thus different levels of explanation across the different subdisciplines. Theology too has its own methods appropriate to its own object but there are differing views on the role of explanation. He discusses an important case study, that of "non-reductive physicalism" associated with Nancey Murphy and others. He also gives criteria for drawing an "inference to the best explanation." Various perspectives on the philosophy of science--logical positivism and the criteria of verification, falsificationism, and Kuhn's paradigm shifts--are discussed. Worthy of mention here would have been Imre Lakatos whose "methodology of scientific research programmes" has been applied to theology by Philip Hefner and Nancey Murphy. *Complementing the above there follows a useful chapter on science and the philosophy of religion. McGrath describes arguments for the existence of God, beginning with Aquinas's five ways. A section on the Kalām cosmological argument notes how this has been given a new lease on life by the Big Bang theory's postulation of a temporal origin to the universe, although it would have been good to note that the existence of the universe would demand an explanation even if it were to lack a temporal origin. He gives a careful analysis of Paley's natural theology, noting neglected aspects of Paley's work such as his responses to arguments of David Hume. He examines ways in which God may act in the world given the laws of nature uncovered by science, including through miracles, where he notes Hume's critique. However, as McGrath rightly says, Hume's critique needs to be qualified, since, on the one hand, he defines miracles as violations of laws of nature and yet, on the other, has a problem with inductive generalizations from past experience--which is just what laws of nature are. McGrath rightly sees evolutionary arguments debunking religion as committing the genetic fallacy and self-defeating if human rationality is flawed, since that could equally well affect judgments in areas other than religion, notably science. There is a good section on natural theology and the role of explanation. *In the next chapter, McGrath turns to models and analogies: first, as found within the natural sciences and then, within religion. After considering what the terms mean more generally, he gives specific examples for the sciences, including the kinetic theory of gases, wave-particle duality, Galileo's analogical reasoning which led him to postulate mountains on the moon, and Darwin's metaphor of "natural selection." In the theological sphere, he considers Aquinas's notion of analogia entis whereby the creation bears a likeness to its creator, and Ian Ramsey's model of the "divine economy" utilizing the Greek concept of oikonomia. He looks at Arthur Peacocke's theological application of models as linked to "critical realism," and Sally McFague's metaphors in theology--though he could perhaps have allowed more than one sentence on Janet Soskice. He then examines specific theological examples: creation and theories of the atonement. He has a helpful section on the notion of "mystery" in science and religion before returning to Ian Barbour on models. *McGrath's final chapter considers a number of contemporary debates. Noting Hume's distinction between "ought" and "is" he critiques the idea that science, say, evolutionary biology or neuroscience, can determine ethics and moral values. That leads to a more general critique of the imperialist stance that science can answer all interesting questions or that the only reality is that disclosed by science. An interesting example is mathematics, which discovers truths that do not belong to the natural sciences. It is also utterly astonishing that mathematics is effective in describing nature and very hard to explain on an atheistic view. *An important area considered is theodicy, which is arguably made more difficult by the long process of evolution, preceding the existence of humans by hundreds of millions of years. McGrath provides an overview of the helpful contributions of Christopher Southgate and his former student Bethany Sollereder. For these scholars, there is "no other way" for God to create such a rich diversity of creatures, with whom God suffers, and for whom God will bring eschatological fulfilment. On transhumanism, McGrath describes the approaches of Philip Hefner and Ted Peters who, while recognizing the creativity of technological enhancement, are also aware that, given fallen human nature, this can also be abused. *McGrath returns to the anthropic principle and fine-tuning. He says that fine-tuning is strongly consistent with a theistic perspective, but the debate about a multiverse as a possible explanation continues. He also considers the legitimacy of teleological language and directionality in biology. Simon Conway Morris's notion of convergent evolution may be the "best explanation" of what is observed and is resonant with a religious perspective but, like cosmological fine-tuning, does not prove that God exists. *McGrath concludes with two sections on the psychology of religion, considering whether this field can "explain away" religion. Religion may be "natural," but it is debatable as to whether that has any implication at all about the existence of God. Moreover, it is a long way from primitive apprehension of some vague supernatural agent to the systematic theology of, say, Thomas Aquinas or Karl Barth. To my mind, this is not unlike the difference--to give a scientific analogy--between the discovery of fire by early humans and the modern scientific understanding of combustion. *This is an excellent introduction to the field and very well suited to its pedagogic purpose. There are a few typographical errors (e.g., "magisterial" for "magisteria"). I also noticed that British cosmologist Paul Davies is mistakenly described as American. But these and my earlier minor points should not detract from a volume that provides a vital resource to educators and their students. *Reviewed by Rodney Holder, Emeritus Course Director, The Faraday Institute for Science and Religion, Cambridge, UK CB3 0UB.
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KITLV, Redactie. "Book Reviews." New West Indian Guide / Nieuwe West-Indische Gids 70, no. 3-4 (1996): 309–81. http://dx.doi.org/10.1163/13822373-90002626.
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-Bridget Brereton, Emilia Viotti Da Costa, Crowns of glory, tears of blood: The Demerara slave rebellion of 1823. New York: Oxford University Press, 1994. xix + 378 pp.-Grant D. Jones, Assad Shoman, 13 Chapters of a history of Belize. Belize city: Angelus, 1994. xviii + 344 pp.-Donald Wood, K.O. Laurence, Tobago in wartime 1793-1815. Kingston: The Press, University of the West Indies, 1995. viii + 280 pp.-Trevor Burnard, Howard A. Fergus, Montserrat: History of a Caribbean colony. London: Macmillan Caribbean, 1994. x + 294 pp.-John L. Offner, Joseph Smith, The Spanish-American War: Conflict in the Caribbean and the Pacific, 1895-1902. London: Longman, 1994. ix + 262 pp.-Louis Allaire, John M. Weeks ,Ancient Caribbean. New York: Garland, 1994. lxxi + 325 pp., Peter J. Ferbel (eds)-Aaron Segal, Hilbourne A. Watson, The Caribbean in the global political economy. Boulder CO: Lynne Rienner, 1994. ix + 261 pp.-Aaron Segal, Anthony P. Maingot, The United States and the Caribbean. London: Macmillan Caribbean, 1994. xi + 260 pp.-Bill Maurer, Helen I. Safa, The myth of the male breadwinner: Women and industrialization in the Caribbean. Boulder CO: Westview, 1995. xvi + 208 pp.-Peter Meel, Edward M. Dew, The trouble in Suriname, 1975-1993. Westport CT: Praeger, 1994. xv + 243 pp.-Henry Wells, Jorge Heine, The last Cacique: Leadership and politics in a Puerto Rican city. Pittsburgh PA: University of Pittsburgh Press, 1993. ix + 310 pp.-Susan Eckstein, Jorge F. Pérez-López, Cuba at a crossroads: Politics and economics after the fourth party congress. Gainesville: University Press of Florida, 1994. xviii + 282 pp.-David A.B. Murray, Marvin Leiner, Sexual politics in Cuba: Machismo, homosexuality, and AIDS. Boulder CO: Westview, 1994. xv + 184 pp.-Kevin A. Yelvington, Selwyn Ryan ,Sharks and sardines: Blacks in business in Trinidad and Tobago. St. Augustine, Trinidad: Institute of social and economic studies, University of the West Indies, 1992. xiv + 217 pp., Lou Anne Barclay (eds)-Catherine Levesque, Allison Blakely, Blacks in the Dutch world: The evolution of racial imagery in a modern society. Bloomington: Indiana University Press, 1993. xix + 327 pp.-Dennis J. Gayle, Frank Fonda Taylor, 'To hell with paradise': A history of the Jamaican tourist industry. Pittsburgh: University of Pittsburgh Press, 1993. ix + 239 pp.-John P. Homiak, Frank Jan van Dijk, Jahmaica: Rastafari and Jamaican society, 1930-1990. Utrecht: ISOR, 1993. 483 pp.-Peter Mason, Arthur MacGregor, Sir Hans Sloane: Collector, scientist, antiquary, founding Father of the British Museum. London: British Museum Press, 1994.-Philip Morgan, James Walvin, The life and times of Henry Clarke of Jamaica, 1828-1907. London: Frank Cass, 1994. xvi + 155 pp.-Werner Zips, E. Kofi Agorsah, Maroon heritage: Archaeological, ethnographic and historical perspectives. Kingston: Canoe Press, 1994. xx + 210 pp.-Michael Hoenisch, Werner Zips, Schwarze Rebellen: Afrikanisch-karibischer Freiheitskampf in Jamaica. Vienna Promedia, 1993. 301 pp.-Elizabeth McAlister, Paul Farmer, The uses of Haiti. Monroe ME: Common Courage Press, 1994. 432 pp.-Robert Lawless, James Ridgeway, The Haiti files: Decoding the crisis. Washington DC: Essential Books, 1994. 243 pp.-Bernadette Cailler, Michael Dash, Edouard Glissant. Cambridge: Cambridge University Press, 1995. xii + 202 pp.-Peter Hulme, Veronica Marie Gregg, Jean Rhys's historical imagination: Reading and writing the Creole. Chapel Hill: University of North Carolina Press, 1995. xi + 228 pp.-Silvia Kouwenberg, Francis Byrne ,Focus and grammatical relations in Creole languages. Amsterdam/Philadelphia: John Benjamins, 1993. xvi + 329 pp., Donald Winford (eds)-John H. McWhorter, Ingo Plag, Sentential complementation in Sranan: On the formation of an English-based Creole language. Tübingen: Max Niemeyer, 1993. ix + 174 pp.-Percy C. Hintzen, Madan M. Gopal, Politics, race, and youth in Guyana. San Francisco: Mellen Research University Press, 1992. xvi + 289 pp.-W.C.J. Koot, Hans van Hulst ,Pan i rèspèt: Criminaliteit van geïmmigreerde Curacaose jongeren. Utrecht: OKU. 1994. 226 pp., Jeanette Bos (eds)-Han Jordaan, Cornelis Ch. Goslinga, Een zweem van weemoed: Verhalen uit de Antilliaanse slaventijd. Curacao: Caribbean Publishing, 1993. 175 pp.-Han Jordaan, Ingvar Kristensen, Plantage Savonet: Verleden en toekomst. Curacao: STINAPA, 1993, 73 pp.-Gerrit Noort, Hesdie Stuart Zamuel, Johannes King: Profeet en apostel in het Surinaamse bosland. Zoetermeer: Boekencentrum, 1994. vi + 241 pp.
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Baker, K. F., F. Rayner, H. Lemos, et al. "OP0074 DISTINCT CIRCULATING LYMPHOCYTE SUBSETS DISTINGUISH FLARE FROM DRUG-FREE REMISSION IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 50.1–51. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1341.
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BackgroundRheumatoid arthritis (RA) is characterised by relapsing joint and systemic inflammation, yet the immunopathological basis of these disease flares and their clinical prediction remain uncertain.ObjectivesUsing mass cytometry and single cell RNA sequencing, we aimed to identify circulating lymphocyte subsets associated with RA flare, and identify potential cellular biomarkers to predict flare versus drug-free remission (DFR).MethodsWe analysed peripheral blood mononuclear cells (PBMCs) from patients recruited to the BioRRA study (Figure 1), a prospective clinical trial of conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) cessation.[1] Patients with RA in clinical (DAS28-CRP < 2.4) and ultrasound (absence of power Doppler signal in 7 joints) remission stopped csDMARDs, with flare defined as DAS28-CRP ≥ 2.4 during 6 month follow-up. A 44-marker mass cytometry panel was used to profile PBMCs from 36 patients (20 flare, 16 DFR) at two time points each (baseline, and flare onset / month 6 DFR). In a subset of patients (n = 12: 8 flare, 4 DFR), fluorescence-activated cell sorting of T and B cells was followed by single cell sequencing (n = 81,923 cells) incorporating 320 immune genes, 34 oligo-tagged surface protein antibodies, and TCR/BCR CDR3 sequence. Clones were defined as ≥2 cells with identical CDR3 nucleotide sequence, and clonal expansion as a significant increase in proportion from baseline to final study visit. Statistical significance was assessed after Benjamini-Hochberg multiple test correction (adj p < 0.05).Figure 1.ResultsMass cytometry revealed 31 distinct cell clusters: notably, greater proportions of memory (CD45RO+/PD1hi) CD4+ and CD8+ T cells, and memory (CD27+/CD21-) B cells, were observed at onset of flare versus baseline (Table 1).Table 1.Mass cytometry (n = 20 flare + 16 DFR)ContrastClusterMedian %Adj. p (GLMM)Flare onset vs baseline: Flare patientsCD4+/CD45RO+/PD1+ memory T cells2.14 vs 0.24<0.001CD8+/CD45RO+/PD1+ memory T cells6.64 vs 0.07<0.001CD19+/CD27+/CD21- memory B cells2.39 vs 0.03<0.001Single cell RNAseq (n = 8 flare + 4 DFR)ContrastClusterMedian %Adj. p (Wilcoxon)Flare onset vs baseline: Flare patientsIgA+ plasma cells0.37 vs 0.210.020Flare vs DFR patients: BaselineCD4+/CD25+/Foxp3+ Treg cells0.55 vs 1.270.022To better characterise these flare-associated subsets, single cell sequencing of CD45RO+/PD1hi CD4+ and CD8+ T cells, and CD19+ B cells, was performed and identified 21 distinct clusters. CDR3 sequencing revealed significant clonal expansion (Fisher exact, adj. p < 0.05) at flare onset within five unique CD8+ clones (4 patients), one CD4+ clone (1 patent), and no B clones. Overall, there was a significantly greater proportion of IgA+ plasma cells at flare onset versus baseline. In contrast, a significantly lower proportion of CD25+/FoxP3+ regulatory T cells were present at csDMARD cessation (baseline) in subsequent flare versus DFR patients (Table 1), suggesting biomarker potential.To further assess the predictive performance of CD4+ Tregs as a biomarker for flare versus DFR, we analysed PBMCs from an independent cohort of 50 patients (25 flare, 25 DFR) stopping csDMARDs in the ongoing BIO-FLARE study.[2] By flow cytometry, we confirmed a lower proportion of CD4+/CD25hi Tregs at baseline in flare vs DFR (median 4.74 versus 6.37%, Wilcoxon p = 0.037; AUC: 0.67). In this cohort, stopping csDMARDs only in patients with elevated (> 6.11% total CD4) baseline Tregs would have prevented drug cessation in 18/25 (72%) of flare patients; 9/25 (36%) of DFR patients would have continued csDMARDs unnecessarily.ConclusionWe present a detailed longitudinal characterisation of circulating lymphocyte surface phenotype, gene expression, and clonal expansion in RA flare vs DFR. Furthermore our data, across two independent cohorts, suggests a role for CD4+ Tregs in promoting drug-free remission meriting further investigation, with potential for future clinical biomarker development.References[1]Baker et al; J Autoimmunity; 105:102298[2]Rayner et al; BMC Rheumatology; 5:22AcknowledgementsThis work was funded by research grants from Wellcome Trust [102595/Z/13/A to KFB], Newcastle NIHR Biomedical Research Centre [BH136167/PD0045 to KFB], British Society for Rheumatology [KFB], Academy of Medical Sciences [SGL022\1074 to KFB], Newcastle University Wellcome Trust Translational Partnership [KFB], Newcastle Hospitals Charity [8033 to KFB], and a National Institute for Health Research Clinical Lectureship [CL-2017-01-004 to KFB]. Our work is supported by the Research into Inflammatory Arthritis Centre Versus Arthritis (RACE) (grant number 20298), and Rheuma Tolerance for Cure (European Union Innovative Medicines Initiative 2, grant number 777357). AGP and JDI are named as inventors on a patent application by Newcastle University (“Prediction of Drug-Free Remission in Rheumatoid Arthritis”; International Patent Application Number PCT/GB2019/050902). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care.Disclosure of InterestsKenneth F Baker Consultant of: Modern Biosciences Ltd, Grant/research support from: Pfizer, Genentech, Fiona Rayner: None declared, Henrique Lemos: None declared, David McDonald: None declared, Gillian Hulme: None declared, Rafiqul Hussain: None declared, Jonathan Coxhead Speakers bureau: Tesaro, Arthur Pratt Grant/research support from: Pfizer, Gilead, Amy E. Anderson: None declared, Andrew Filby Grant/research support from: Becton Dickinson, John Isaacs Speakers bureau: Abbvie, Gilead, Roche, UCB, Grant/research support from: GSK, Janssen, Pfizer.
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Bashonga, Bishobibiri Alexis, Sande Eric, and Ntakimazi Gaspard. "Bird Management in the Ruzizi Delta, Northern End of Lake Tanganyika in Burundi and the Democratic Republic of Congo." Biolife 11, no. 1 (2023): 70–82. https://doi.org/10.5281/zenodo.7754424.
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<strong>Abstract</strong> The investigation of the management of birds in the Ruzizi Delta was conducted as part of a global doctoral research on the ecology, conservation and management of birds in the Ruzizi Delta through direct observation, the real bibliography and the virtual bibliography by internet. Direct observation led us to report on the problems of soils, hydrology, land and vegetation cover, wild animals on the banks of rivers and islets, natural ponds, lagoons and the coast of Lake Tanganyika. The real and virtual bibliography on the internet has revealed to us the development plans that we suggest for the Rusizi Burundian Delta (RBD) and for the Ruzizi Congolese Delta (RCD). It recommends the formulation of projects in synergy for the conservation of birds and biodiversity in the RBD and the RCD. For the DRC, the study recommends legislating on the creation of a community reserve for the Ruzizi Congolese wetlands delta protection as was the case before the wars of 1996-2003. For Burundi, the study recommends the reforestation of a buffer zone for the demarcation of wetlands in areas in full urbanization, particularly around the City of Gatumba. <strong>Key words:</strong> Bird Management; Development of crocodiles; Hippos management; Biodiversity management plan; Wild animals of the banks and islets. <strong>References</strong> ABO. (2008). <em>Burundi’s Important Bird Areas, Status and Trends in 2008.</em> Bujumbura: ABO (Association Burundaise pour la protection des Oiseaux), 58 pages. www.abo-conservation-bi.org. ADBG. (2015). <em>Ruzizi III Hydropower Plant (147 MW), Environmental and Social Impact Assessment (ESIA) Summary.</em> Abidjan: ADBG (African Development Bank Group), 28 pages. ADBG. 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"The David Hume Institute, Edinburgh." Economic Affairs 6, no. 1 (1985): 34. http://dx.doi.org/10.1111/j.1468-0270.1985.tb01715.x.
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"Book Reviews." Journal of Economic Literature 53, no. 2 (2015): 360–61. http://dx.doi.org/10.1257/jel.53.2.360.r1.
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James K. Galbraith of University of Texas at Austin reviews “Keynes: Useful Economics for the World Economy”, by Peter Temin and David Vines. The Econlit abstract of this book begins: “Provides an introduction to Keynesian ideas that connect John Maynard Keynes's insights to today's global economy and offers a way to understand current policy debates. Discusses economics before Keynes─David Hume; Keynes at Versailles; Keynes and the Macmillan Committee; economics before Keynes─Alfred Marshall; The General Theory; IS-LM curves; the liquidity trap; Bretton Woods and the Swan diagram; the Keynesan age─crises and reactions; and an international paradox of thrift.” Temin is Elisha Gray II Professor Emeritus of Economics at the Massachusetts Institute of Technology. Vines is Professor of Economics and Fellow of Balliol College at the University of Oxford.
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"Real-World Gait Detection Using a Wrist-Worn Inertial Sensor: Validation Study." JMIR Formative Research, May 13, 2024. https://doi.org/10.2196/50035.
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Felix Kluge <sup>1</sup>, PhD; Yonatan E Brand <sup>2</sup>, MSc; M Encarna Micó-Amigo <sup>3</sup>, PhD; Stefano Bertuletti <sup>4</sup>, PhD; Ilaria D'Ascanio <sup>5</sup>, MSc; Eran Gazit <sup>6</sup>, MSc; Tecla Bonci <sup>7</sup>, PhD; Cameron Kirk <sup>3</sup>, PhD; Arne Küderle <sup>8</sup>, MSc; Luca Palmerini <sup>5, 9</sup>, PhD; Anisoara Paraschiv-Ionescu <sup>10</sup>, PhD; Francesca Salis <sup>4</sup>, PhD; Abolfazl Soltani <sup>10</sup>, PhD; Martin Ullrich <sup>8</sup>, PhD; Lisa Alcock <sup>3, 11</sup>, PhD; Kamiar Aminian <sup>10</sup>, PhD; Clemens Becker <sup>12, 13</sup>, MD; Philip Brown <sup>14</sup>, MSc; Joren Buekers <sup>15, 16, 17</sup>, PhD; Anne-Elie Carsin <sup>15, 16, 17</sup>, MSc; Marco Caruso <sup>4</sup>, PhD; Brian Caulfield <sup>18, 19</sup>, PhD; Andrea Cereatti <sup>4</sup>, PhD; Lorenzo Chiari <sup>5, 9</sup>, PhD; Carlos Echevarria <sup>3, 20</sup>, PhD; Bjoern Eskofier <sup>8</sup>, PhD; Jordi Evers <sup>21</sup>, MSc; Judith Garcia-Aymerich <sup>15, 16, 17</sup>, PhD; Tilo Hache <sup>1</sup>, Dipl-Ing (FH), MBA; Clint Hansen <sup>22</sup>, PhD; Jeffrey M Hausdorff <sup>6, 23, 24, 25, 26</sup>, PhD; Hugo Hiden <sup>14</sup>, PhD; Emily Hume <sup>27</sup>, PhD; Alison Keogh <sup>18, 19</sup>, PhD; Sarah Koch <sup>15, 16, 17</sup>, PhD; Walter Maetzler <sup>22</sup>, MD; Dimitrios Megaritis <sup>27</sup>, PhD; Martijn Niessen <sup>21</sup>, PhD; Or Perlman <sup>2, 23</sup>, PhD; Lars Schwickert <sup>12</sup>, PhD; Kirsty Scott <sup>7</sup>, PhD; Basil Sharrack <sup>28, 29</sup>, PhD; David Singleton <sup>18, 19</sup>, MSc; Beatrix Vereijken <sup>30</sup>, PhD; Ioannis Vogiatzis <sup>27</sup>, PhD; Alison Yarnall <sup>3, 11, 14</sup>, PhD; Lynn Rochester <sup>3, 11, 14</sup>, PhD; Claudia Mazzà <sup>7</sup>, PhD; Silvia Del Din <sup>3, 11</sup>, PhD; Arne Mueller <sup>1</sup>, PhD <sup>1 </sup>Novartis Biomedical Research, Novartis Pharma AG, Basel, Switzerland <sup>2 </sup>Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel <sup>3 </sup>Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom <sup>4 </sup>Department of Electronics and Telecommunications, Politecnico di Torino, Turin, Italy <sup>5 </sup>Department of Electrical, Electronic and Information Engineering, University of Bologna, Bologna, Italy <sup>6 </sup>Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel <sup>7 </sup>Department of Mechanical Engineering and Insigneo Institute for In Silico Medicine, The University of Sheffield, Sheffield, United Kingdom <sup>8 </sup>Machine Learning and Data Analytics Lab, Department of Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany <sup>9 </sup>Health Sciences and Technologies-Interdepartmental Center for Industrial Research (CIRI-SDV), University of Bologna, Bologna, Italy <sup>10 </sup>Laboratory of Movement Analysis and Measurement, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland <sup>11 </sup>National Institute for Health and Care Research (NIHR) Newcastle Biomedical Research Centre (BRC), Newcastle University and The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom <sup>12 </sup>Robert Bosch Gesellschaft für Medizinische Forschung, Stuttgart, Germany <sup>13 </sup>Unit Digitale Geriatrie, Universitätsklinikum Heidelberg, Heidelberg, Germany <sup>14 </sup>The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom <sup>15 </sup>Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain <sup>16 </sup>Universitat Pompeu Fabra, Barcelona, Spain <sup>17 </sup>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain <sup>18 </sup>Insight Centre for Data Analytics, University College Dublin, Dublin, Ireland <sup>19 </sup>School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland <sup>20 </sup>Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom <sup>21 </sup>McRoberts BV, The Hague, Netherlands <sup>22 </sup>Department of Neurology, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany <sup>23 </sup>Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel <sup>24 </sup>Department of Physical Therapy, Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel <sup>25 </sup>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States <sup>26 </sup>Department of Orthopaedic Surgery, Rush Medical College, Chicago, IL, United States <sup>27 </sup>Department of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle upon Tyne, United Kingdom <sup>28 </sup>Department of Neuroscience, The University of Sheffield, Sheffield, United Kingdom <sup>29 </sup>Sheffield NIHR Translational Neuroscience BRC, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom <sup>30 </sup>Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway
Books on the topic "David Hume Institute"
1
Institute, David Hume, ed. The David Hume Institute: The first decade. David Hume Institute, 1996.
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2
Institute, David Hume, ed. Alan Peacock dissenting: Essays in memory of the founder of the David Hume Institute. David Hume Institute, 2015.
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3
Richard, Dale, and David Hume Institute, eds. Financial deregulation: The proceedings of a conference held by the David Hume Institute in May 1986. Woodhead-Faulkner, 1986.
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4
Massie, Allan. How should health services be financed?: A patient's view : report of a conference organized by the David Hume Institute and Royal College of Physicians, Edinburgh held on 10 June 1988. Aberdeen University Press, 1988.
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5
Foster, Robin. Public Broadcasters: Accountability and Efficiency (The David Hume Institute : Hume Paper, 18). Edinburgh University Press, 1993.
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