Academic literature on the topic 'Days later'

✓ Laser energy at a wavelength of 480 nm was applied in 1-µsec pulses of 3 to 10 mJ to two models of vasospasm. Rabbit common carotid arteries (CCA's) were constricted chronically by the application of human blood within a silicone sheath. Peak vasospasm developed 24 to 48 hours later, and persisted for up to 6 days. Endovascular laser treatment was delivered to 40 CCA's via a 200-µm diameter silica quartz fiber introduced through the femoral artery. The CCA caliber increased from 60% of the pre-vasospasm control diameter to a minimum post-laser diameter of 83% of control. No instances of laser-induced perforation or of arterial thrombosis were observed for up to 60 days after treatment. Prophylactic laser application to nine normal vessels was able to attenuate the development of vasospasm if blood was applied immediately thereafter (88% vs. 59% of control diameter, p < 0.02), but not if blood was applied 7 days later. Studies in 16 normal CCA's established that there was a considerable margin between the laser energy required to induce dilatation and that which caused perforation, providing that the fiber remained relatively central within the artery. Morphological examination demonstrated focal loss of endothelial cells immediately after laser application, followed approximately 7 days later by the development of areas of intimal hyperplasia. Only minimal changes were observed in the medial or adventitial layers. In a second study, the basilar artery of seven dogs was constricted chronically by two intracisternal injections of autologous blood 3 days apart. Five dogs received endovascular laser treatment 7 or 10 days after the first injection, when basilar artery diameter was reduced to a mean of 61% and 77% of control, respectively. Immediately following treatment, basilar artery diameter increased to 104% and 102% of resting diameter, respectively. Both untreated and laser-treated arteries were smaller than the control diameter at 30 days (80% and 82%, respectively), but in each group the vasodilatory response to hypercapnia was preserved. These findings indicate that 1-µsec laser pulses are well tolerated by systemic and cerebral arteries in two different animal models, and suggest that the 480-nm pulsed-dye laser may have an application for the treatment or prophylaxis of cerebral vasospasm.

L'apparente pérennité de la figure du zombie, sa résurrection périodique à des moments charnières de l'histoire et son évolution suggère qu'elle pourrait jouer un rôle symbolique au sein de la société où elle prend forme. Le mandat de cette étude consiste donc d'abord à dresser un portrait du zombie contemporain en clarifiant la provenance ainsi que les origines du mythe et en prenant bien soin de définir les caractéristiques récurrentes du monstre à travers les époques et nations. Ensuite, il tient à étudier trois différents films provenant de trois différentes époques soient : White Zombie (1932) de Victor Halperin, Dawn of the Dead (1978) de George A. Romero et 28 Days Later (2002) de Danny Boyle et Alex Garland. Ces films sont analysés en fonction de l'attitude du zombie, de ses caractéristiques, des motivations apparentes, de son pouvoir et impact sur la population. En somme, l'objectif vise ici à établir un portrait de la figure du zombie au cinéma, à donner un aperçu de son évolution, et à déterminer la nature du rôle, qu'il semble exercer sur la société représentée où il sévit.

This dissertation explores a body of films produced after the events of 9/11, and while examining this specific point of departure, the author presents the argument on the vast cultural relevancy of the omnipresent zombie. These films are interrogative and complex, offering the viewing audience a rich tapestry of interwoven meanings. Furthermore, the author suggests that the zombie trope has, in fact, left the genre altogether, reinserted into a style of films he labels as "non-zombie appropriation." Chapter 1 introduces the zombie genre as both part of the larger horror genre aesthetic and as its' own legitimate subgenre. The zombie has a rich cinematic history, going back more than seven decades; heretofore, the last decade continues to see an unabated release of the viewing world's favorite creature. Chapter 2 examines 28 Days Later and the sequel 28 Weeks Later as critical films functioning as works that refocus the zombie for the twenty-first century. As no serious discussion of filmic zombies can occur without the immeasurable significance of George A. Romero, chapter 3 concentrates on the auteur reclaiming a genre he helped to invent with his films Land of the Dead and Diary of the Dead. These two works show a director that refuses to rest on his laurels by encoding these films with rich post-9/11 concerns. In chapter 4, the examination of the disparate films Equilbruim and The Happening discuss the utilization of non-zombie appropriations, films with no discernible zombies, but for all intents and purpose, imitate that specific narrative. By way of conclusion, chapter 5 continues the non-zombie trope with the abstract (and indeed postmodern) They Came Back. The chapter ends with an augmentation of the framework and with other concerns for the argument. This dissertation should be of interest to both horror scholarship overall and zombie films in particular. It aims to provide a refined reading of a significant body of works and add to the current and critical legitimization to this important style of cinematic artistry.

No tratamento endodôntico, várias fases de igual importância são necessárias para a realização de uma terapêutica bem sucedida, entre elas podemos citar a instrumentação. Apesar de todas as técnicas e instrumentos propostos para a Endodontia, o sucesso esperado ainda não foi alcançado. Tanto a instrumentação manual quanto à rotatória não resulta na limpeza das áreas polares dos canais radiculares com achatamento mésio-distal. No intuito de obter melhor resultado clínico, avaliou-se “in vitro” a remoção da camada de “smear” das paredes dos canais radiculares de 40 dentes incisivos inferiores portadores de achatamento mésio-distal submetidos à instrumentação rotatória por meio da técnica “Free Tip Preparation”, utilizando o laser de Er: YAG nos parâmetros de 140 e 250 mJ. Para tanto, a fibra óptica do aparelho foi deslocada lentamente, com velocidade de 2 mm/s, até o orifício cervical na câmara pulpar, na parede vestibular e lingual da raiz; e sua eficácia na remoção da “smear” foi comparada aos grupos onde se utilizou apenas Hipoclorito a 2,5% e Hipoclorito de sódio a 2,5% alternado com EDTA a 17%. Os dentes foram analisados por meio de microscopia eletrônica de varredura, e as fotomicrografias das áreas mais representativas dos terços médio e apical foram avaliadas por três examinadores diferentes, com grau mínimo de Mestre, que observaram a quantidade da camada de “smear” presente nas amostras em relação a três padrões. Os examinadores, sem que tivessem o conhecimento prévio de qual dos grupos estavam avaliando, atribuíram escores de 1 a 4 as fotomicrografias, de acordo com a quantidade da camada de “smear” visualizada. Os dados obtidos foram submetidos à análise estatística não-paramétrica, comparando-se os diferentes grupos estudados (teste de Kruskal-Wallis) e os terços radiculares (teste de Wilcoxcon). Os resultados mostraram que, quanto à quantidade da “smear” encontrada nos grupos estudados, o grupo que utilizou Hipoclorito a 2,5% alternado com EDTA apresentou os canais radiculares mais limpos seguido do grupo do laser 250 mJ e posteriormente pelos grupos do laser Er: YAG a 140 mJ e do hipoclorito a 2,5%, que não apresentaram diferença estatisticamente significante entre si. Quanto aos terços, o apical apresentou maior quantidade da “smear” em comparação com o terço médio (p< 0,01).<br>Manual or rotary instrumentation techniques do not efficiently clean mesio-distal flattened root canals. This study evaluated, in vitro, smear layer removal of 40 mesio-distal flattened root canals after rotary instrumentation. The teeth were then divided into 4 groups: group 1: rotary instrumentation and 2.5% sodium hypochlorite used as irrigating solution; group 2: instrumented as group 1 and followed by Er: YAG laser irradiation (140mJ input/10Hz), withdrawn at 2mm/s from the apical to the cervical region touching the buccal walls the procedure was then repeated for the lingual wall); group 3: instrumented as group 1 and followed by Er: YAG laser irradiation (250mJinput/10Hz) withdrawn at 2mm/s from the apical to the cervical region touching the buccal walls the procedure was then repeated for the lingual wall) and group 4: instrumented as group 1 and alternated with 17% EDTA Teeth were split longitudinally and prepared for examination under scanning electron microscopy. Scores from 1 to 4 were given to the fotomicrographs by three independent evaluators, and these data was submitted to statistical analysis. The teeth where alternated 17% EDTA were used (group 4) showed less amount of smear layer, followed by the group irradiated with 250mJinput/10Hz (group 3), the group irradiated with 140mJ input/10Hz and the group where only sodium hypochlorite was used. The apical third presented more smear layer than the middle third (p<00.1).

Made available in DSpace on 2014-06-11T19:24:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-07-05Bitstream added on 2014-06-13T19:51:19Z : No. of bitstreams: 1 silva_prp_me_sjc.pdf: 750069 bytes, checksum: 94263aef7c378118e8087ea9d933ad86 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O objetivo desta pesquisa foi avaliar a influência do laser Nd:YAG nas propriedades mecânicas (dureza e módulo de elasticidade) da interface adesiva, utilizando a técnica da nanoindentação, empregando-se sistema adesivo convencional Adper Single Bond 2 – 3M ESPE (SB) ou autocondicionante Clearfil SE Bond – Kuraray (CSE). Doze terceiros molares humanos tiveram suas superfícies oclusais desgastadas até a exposição da dentina superficial. Uma cavidade circular padronizada com fresa 3053 foi realizada na superfície oclusal proporcionando 2 mm de dentina remanescente. Os espécimes foram embutidos em resina acrílica, e seccionados no sentido mésio-distal, sendo as 24 hemi-coroas obtidas divididas em quatro grupos: Grupo controle (SBC) - aplicação do sistema SB de acordo com as recomendações do fabricante; Grupo laser (SBL) - aplicação do sistema adesivo SB e tratamento com laser Nd:YAG (140mJ/cm2/60s/não contato); Grupo controle (CSEC) - aplicação do sistema adesivo autocondicionante CSE de acordo com as recomendações do fabricante; Grupo laser (CSEL)- aplicação do sistema adesivo autocondicionante CSE e tratamento com laser Nd:YAG (140mJ/cm2/60s/não contato). Após a polimerização dos sistemas adesivos, foram aplicados dois incrementos da resina composta Filtek Z 350 (3M ESPE). Os corpos-de-prova foram imersos em água destilada e armazenados por 24h em estufa 37ºC e submetidos à nanoidentação em aparelho Nano Indenter® XP (MTS®, MN, EUA).. Os resultados foram submetidos aos testes estatísticos de Análise de Variância (ANOVA), Tukey e t-Student (p<0,05). Concluiu-se que a aplicação do laser Nd:YAG em ambos os sistemas adesivos não alterou o nível de dureza da interface adesiva, no entanto alterou o módulo de elasticidade<br>The aim of this study was to evaluate the influence of Nd: YAG laser on the mechanical properties (hardness and modulus of elasticity) of the adhesive interface, using the technique of nanoindentation, employing conventional adhesive system Single Bond 2 3M ESPE (SB) or selfetching adhesive system Clearfil SE Bond - Kuraray (CSE). On 12 human molars, a flat superficial dentin surface was exposed by abrasion. A standardized circular cavity with bur 3053 was performed on the occlusal surface and dentin thickness was standardized in 2 mm. The specimens were embedded in resin acrylic and sectioned mesio-distally through their long axes, and the 24 hemi-crowns obtained divided into four groups: Control Group (SBC) – the application of SB system according to the manufacturer's recommendations; Laser Group (SBL) – SB adhesive system and treatment with Nd: YAG laser (140mJ/cm2/60s/no contact) Control Group (CSEC) – application of CSE self-etching adhesive system according to the manufacturer's recommendations; Laser Group (CSEL) – application of CSE self-etching adhesive system and treatment with Nd: YAG laser (140mJ/cm2/60s/no contact). After polymerization of the adhesives, were applied two increments of composite resin Filtek Supreme and specimens were immersed in distilled water and stored for 24 hours at 37 ºC and submitted to nanoidentation in Nano Indenter ® XP (MTS ®, MN, USA. Nanoindentation were made on composite resin, adhesive system, hybrid layer and dentin. The results were analyzed by a tree-way ANOVA, Tukey and e t-Students (p<0,05). It was concluded that the application of Nd:YAG laser in both adhesive systems did not change hardness level of hybrid layer, however chanded the elastic modulus

While there is a growing body of knowledge on newlyweds and the transitions they go through, very little is known about the experience of newlyweds who are also members of The Church of Jesus Christ of Latter-day Saints (LDS). The purpose of this study was to gain a picture of the LDS newlywed experience through in-depth interviews. Seeking to understand the overall experience of LDS newlyweds, this study was conducted using a phenomenological perspective to explore how these couplesâ expectations of marriage correspond with their actual experience of marriage, how the LDS faith influenced the expectations and/or experience of marriage, and finally to uncover what external and internal factors helped or hindered their transition to marriage. In-depth interviews were conducted with six young LDS newlywed couples and were coded for themes. The main themes found include the pressure to marry, process of discovering sexual intimacy and an overall evaluation of expectations and experience. Implications for therapists and future research are indicated.<br>Master of Science

A ce jour, il existe tres peu de references de frequences dans le domaine infrarouge (ir). Nous avons mis en uvre des experiences de spectroscopie a trois niveaux a haute resolution dans l'iode moleculaire, afin d'etudier les transitions du type b-x faisant intervenir des niveaux vibrationnels eleves dans l'etat fondamental x. Ces niveaux ne sont pas peuples a l'equilibre thermique a temperature ambiante, donc non accessibles par la technique d'absorption saturee. Les raies d'emission laser correspondant a ces transitions permettraient d'etendre vers le proche ir la gamme des references secondaires de frequence optique

This study examined differences between Latter-Day Saint (LDS) and non-Latter-Day Saint (non-LDS) females across six universities in the United States regarding desire to engage in substance use and eating behaviors in response to negative emotion. Additionally, this study explored differences between LDS and non-LDS females regarding body image, as well as body image differences between LDS females residing inside Utah and outside Utah. Findings suggested that non-LDS females were more likely to experience increased urges to use substances in response to negative emotion than LDS females, consistent with LDS doctrine teaching the avoidance of substance use. LDS females also did not appear to substitute LDS-sanctioned eating behaviors for substance use in response to negative emotion, as has previously been suggested by other researchers. Additionally, LDS females were found to have more positive body image than non-LDS females generally, although LDS females in Utah have less positive body images than LDS females residing in other states. Body image findings are substantial since body image distress is rampant and is a risk factor for the development of eating disorders. Clinical implications, limitations, and future directions are discussed.

AbstractEmma Morano was born on 29 November 1899 in a small mountain village in Piemonte, and died on 15 April 2017 in Verbania on Lake Maggiore (100 km north of Milano). She was the daughter of Giovanni Morano, a miner; and Mathilde Bresciani, aged 24, a weaver. She was the first child in the family, and her arrival was followed by the births of seven siblings, four sisters and three brothers, all of whom she all survived. On 16 October 1926, Emma Morano married Giovanni Martinuzzi, but they separated a few years later after the death of their child. For more than 30 years, she worked in a jute factory. She then worked for about 20 years in the kitchen of a Marianist boarding school until she retired at the age of 75. After retirement, she lived in a small two-room apartment. In her final years, her hearing and sight were greatly reduced, but she could recognise faces and could communicate when spoken to loudly. She seemed to remember both past events and more recent ones. She had never been hospitalised, but had been treated for gastrointestinal bleeding and for urinary infections. She took no drugs regularly except laxatives. In the archives of four municipalities in the region, we obtained copies of the death certificates of her parents, the birth certificates of all of her siblings, her marriage certificate, and the birth and death certificates of her child. We found no inconsistences in the documents.

Shilts enrols at University of Oregon and quickly engages with the Eugene Gay People’s Alliance. Early attempts to start a gay liberation movement among Oregon students, including the university’s first-ever Gay Pride Week. He loses a later bid for Student Body President under a theme of “Come Out for Shilts.” Shilts embraces a “gay centric” approach to schoolwork and his life, living fully out despite some miscues, convinced heterosexuals are unaccepting of homosexuals because they lack understanding or knowledge of gays and lesbians. Oregon classmates recall Shilts’s transition from student politics to journalism. Shilts finds being “out” in conflict with his dreams of a career in mainstream journalism. Shilts writes about a summer job at a gay bathhouse.

This chapter examines how Chelsea Piers facilities, located directly up the Westside Highway from Lower Manhattan, had served a major role in disaster response from the earliest hours of the 9/11 attacks. The piers offered water stations for people fleeing from downtown and became a key debarkation point for the waterborne evacuation, delivering more than 10,000 people off the island from its docks. Then, the following day, more than 30,000 people arrived to volunteer their help and connect with other New Yorkers. In the days that followed, thousands of uniformed personnel were fed in an events center at Pier 60, hundreds of rescuers slept and showered in Chelsea Piers facilities, and truckloads of donations and supplies were assembled and processed for delivery to the trade center site. By Wednesday, the flood of private citizens' donations had been supplemented with massive corporate contributions arriving in bulk. Meanwhile, the Coast Guard was confronted with two opposing missions: protecting potential targets of a second-wave attack and continuing commerce in a port that regularly handled approximately 6,000 inbound and outbound containers daily, the closure of which created complications worldwide.

Although most individuals recover from concussion within 7 to 10 days, a sizable minority have prolonged concussion symptoms, especially those who also suffered loss of consciousness, post-traumatic amnesia, many acute symptoms, and immediate dizziness. Thus, someone could remain symptomatic from concussion more than two weeks following the injury. At that point, however, the discerning clinician must differentiate prolonged concussion symptoms from the evolution of persistent symptoms from comorbid neurologic conditions or emerging mental health symptoms or disorders. Too often, prolonged or persistent symptoms are not considered in the context of initial concussion injury and symptoms, proper return to activity, or emerging comorbid conditions that can also lead to persistent symptoms.

Three days later Innstetten arrived in Berlin, fairly late, around nine. They were all at the station: Effi, her Mama, her cousin. He was warmly received, warmest of all by Effi, and a whole host of matters had already been discussed by the time the...

A few days later, before the month of August had expired, Eustacia and Yeobright sat together at their early dinner. Eustacia’s manner had become of late almost apathetic. There was a forlorn look about her beautiful eyes which, whether she deserved it or not, would...

The construction of dams in rivers negatively affects ecosystems because dams violate the continuity of rivers, transform the biological and physical structure of the river channels, and the most importantly – alter the hydrological regime. The impact on the hydrology of the river can occur through reducing or increasing flows, altering seasonality of flows, changing the frequency, duration and timing of flow events, etc. In order to determine the extent of the mentioned changes, The Indicators of Hydrologic Alteration (IHA) software was used in this paper. The results showed that after the construction of Angiriai dam, such changes occurred in IHA Parameters group as: the water conditions of April month decreased by 31 %; 1-day, 3-days, 7-days and 30-days maximum flow decreased; the date of minimum flow occurred 21 days later; duration of high and low pulses and the frequency of low pulses decreased, but the frequency of high pulses increased, etc. The analysis of the Environmental Flow Components showed, that the essential differences were recorded in groups of the small and large floods, when, after the establishment of the Šušvė Reservoir, the large floods no longer took place and the probability of frequency of the small floods didn’t exceed 1 time per year.

The effect of the combined oral administration of pentoxifylline (pof) and low dose acetylsalicylic acid (ASA) was evaluated with the help of the laser-induced thrombosis model in rat mesenteric arterioles. Laser-induced thrombosis is inhibited in a dose-dependent way by both drugs. The administration of ASA, either simultaneously with or 1 hour prior to pof, does not show any effects in the laser model. On the contrary, the administration of pof followed 1 h later by ASA not onyl exhibited a significant effect but also produced a supraadditive inhibition of the laser-induced thrombus formation. Specific investigations concerning the time interval between the administration of both drugs determined that a significant effect can be achieved only after an interval of 30 to 90 minutes (principle of HWA 5112).The striking results could also be shown in diseased animals after consecutive chronic administration of pof 1 h prior to ASA. HWA 5112 exhibits significant effects on laser-induced thrombus formation in the following chronic animal models: 1. adjuvant arthritic rats, 10 → 1 mg/kg for 21 days; 2. spontaneously hypertensive stroke-prone rats, 10→ 1 mg/kg three times within 24 h; 3. cholesterol-induced atherosclerosis in rabbits, 10→ 1 mg/kg for 14 days. The reported data clearly demonstrate that the sequential drug administration of first pentoxifylline followed 30 to 90 min later by ASA exhibits a supraadditive antithrombotic effect.

Many plants, including Festulolium, grown in temperate climates require vernalization and must experience a period of low winter temperature to initiate or accelerate the flowering process. The aim of research was to investigate impact of vernalisation thermoinduction on growth and development parameters of Festulolium varieties ‘Vėtra’ and ‘Punia DS’. Investigations were carried out in Lithuanian Research Centre for Agriculture and Forestry Institute of Horticulture, Plant Physiology Laboratory of phytotron complex in 2011–2012. Some peculiarities of growth and development of. Festulolium varieties ’Vėtra’ and ‘Punia DS’ were investigated. 5 plants were sown in each 5 litre pot in neutral peat substrate (pH 6–6.5). The plants were grown in greenhouse till the tillering phase at the temperature of 20±2 °C at daytime and 16±2 °C at night. Later plants were moved to low temperature chambers for 90, 110 and 130 days for passing of vernalisation processes, where the 8 and 16 hour photoperiod were maintained at 4 °C temperature. After vernalisation periods plants were removed to a greenhouse for additional 20 days. Biometric parameters, namely plant height, shoot number and dry mass were measured after each period in greenhouse and climatic chambers. The data revealed different response of Festulolium varieties ‘Vėtra’ and ‘Punia DS’ to vernalisation conditions. According to our data ‘Vėtra’ plant height was 6 % higher than the ‘Punia DS’ after 130+20 days of vernalisation. Nonetheless, vernalisation temperature conditions have no significant impact on shoot number. 110 and 130 long-day photoperiod significantly impacted on shoot number of Festulolium ʽVėtraʼ. Otherwise, 90 days vernalisation of both photoperiod induced significantly the highest length of ‘Punia DSʼ shoots. ‘Vėtraʼ accumulated significantly the maximum dry matter after 110 days vernalisation period, than that after 90 and 130 days.

Abstract: The research focuses on the possibility of transferring theoretical ideas of Le Corbusier into educational programs of the very young children – between three and six. The worldwide development of civilization changed the natural environment of the human. For the average European citizen a city is more natural place for living than a forest. Simultaneously, in these days many inhabitants present an extremely conformist approach to life and to the surrounding space. The participation of members of the society in the shaping of public spaces is possible only through the involvement and practice, but the democratic responsibility does not appears out of nowhere. It must be fostered and nurtured as early as in childhood. According to developmental psychology, children in the age of 3-6 are very susceptible to the acquisition of new skills and learn it in an intuitive way. The proper education program using Le Corbusier’s lectures and theory could help them to understand the space better. The seeming simplicity of above rules is an advantage in this case – thereby it can be explained to even such an audience as small children. On the other hand, some kind of abstract and hidden difficulty included in this theory becomes an opportunity to create a very absorbing and stimulating workshops that follow the needs of younger and older children. Le Corbusier’s legacy includes not only physical issues and can be used in many different ways. As Pablo Picasso once stated: every child is an artist, the problem is staying an artist when you grow up. For those reasons, incorporating such an innovative strategy for kids’ education reveals a great potential. Resumen: Los estudios realizados enfocan en comprobar las posibilidades de usar las ideas teóricas de Le Corbusier en los programas educativos para niños de tres a seis años. El desarrollo de la civilización ha cambiado el entorno natural del ser humano - una ciudad para el ciudadano promedio de Europa es un lugar más natural para vivir que el bosque. Al mismo tiempo, hay que reconocer que muchas personas muestran el enfoque muy conformista a la vida, tanto al espacio circundante. Esta situación se podría mejorar mediante la participación consciente de los miembros de la sociedad en la creación del espacio público, su compromiso y la práctica. Pero la responsabilidad democrática no aparece sola, se debe estimularla y nutrir ya en la infancia. De acuerdo con la psicología del desarrollo, los niños de 3 a 6 años son muy susceptibles a la adquisición de nuevas habilidades y aprenden de una manera intuitiva. Programa educativo que utiliza los cursos y la teoría de Le Corbusier puede ayudarles a entender mejor el medio ambiente. La aparente sencillez de los principios proclamados por él en este caso es una ventaja. La abstracción y escondidas dificultades incluidas en ellos,nos permiten a crear actividades estimulantes que correspondan a las necesidades de los niños pequeños, tanto y mayores. Como afirmo Pablo Picasso: "Todo niño es un artista. El problema es cómo mantenerse siendo niño una vez que se ha crecido". Keywords: Architectural education, children, Le Corbusier. Palabras clave: Enseñanza de la arquitectura, los niños, Le Corbusier. DOI: http://dx.doi.org/10.4995/LC2015.2015.891

On February 19, 2003, a 3-year-old child was sent downstairs to retrieve a toy. Shortly after, her guardian heard a noise and ran to find her lying at the bottom of the split-foyer stairs. She was rushed to the hospital immediately by paramedics. She died five days later and the cause of death determined was brain herniation due to anoxic/ischemic brain injury. The objective of this research was to determine which fall scenario(s) matched the trauma sustained utilizing scientifically proven quantitative measures.

As we previously described, plasma infusion increased platelet count (PC) in four patients with IIB von Willebrand disease with severe thrombocytopenia. In a sixty years old patient in the same family, with chronic thrombocytopenia (PC = 30 000/ml) associated to an absence of large von Willebrand Factor multi-mers (vWF) in plasma, we successfully treated :1° A gastrointestinal bleeding episode with fresh frozen plasma infusion (15ml/Kg/day).2° Three months later a severe epistaxis with cryoprecipi-tate supernatant (15ml/Kg/day).During these bleeding episodes, the efficiency of these two treatments on the PC could be ascertained according to the following figureWe observed after ten days of these two treatments the following biological effects : a normalisation of vWF cross immunoelectrophoresis, of ristocetin induced normal platelet aggregation by patient's plasma, and of patient's plasma vWF binding to control platelets.In conclusion a factor appears to be present in both fresh frozen plasma and cryoprecipitate supernatant which prevents the abnormal binding of von Willebrand Factor (in this IIB von Willebrand disease) to the patient's platelets.

Physical exercise leads to a shortening of activated partial thrcnboplastin time (PIT) and euglobulin lysis time (ELT). Whether this activation causes in-vivo thrombin and plasmin action remains controversial however. 19 well trained long distance runners were examined 25 min (range 5-53) after termination of a 100 km race (post-race values) run in 577 min (457-755) and 5 days later after at least one day without physical exercise (control values). FPA, platelet factors and fibrin (ogen) split products (fragment E and BB 15-42) were measured with radioimnunoassays. ELT was assessed before and after venous occlusion (VO). The table gives mean values ±SD:Thrombin time, platelet count, platelet factor 4 and haematocrit did not change significantly. FPA was normal in all post-race samples and did not correlate significantly with the time lag between arrival and blood sampling, indicating that activation of blood coagulation in exhaustive physical exercise of long duration does not lead to in-vivo fibrin formation. Activation of fibrinolysis, however, results in circulating plasmin activity as demonstrated by the elevation of the fibrin (ogen) degradation products fragment E and BB 15-42. Since the polyclonal antibodies used in the latter assay crossreact with BB 1-42, these results alone do not allow to jjdge whether plasmin degrades fibrin or fibrinogen. However, lack of fibrin formation suggests fibrinogenolysis rather than fibrinolysis.

The durability of in-place concrete is a high priority issue for concrete pavements and bridges. Several studies have been conducted by INDOT to use electrical resistivity as a measure of fluid transport properties. Resistivity is dependent on the chemistry of the cement and supplementary cementitious system used, as such it has been recommended that rather than specifying resistivity it may be more general to specify the formation factor. Samples were tested to establish the current levels of performance for concrete pavements in the state of Indiana. Temperature and moisture corrections are presented and acceptable accelerated aging procedure is presented. A standardized testing procedure was developed (AASHTO TP 119–Option A) resulting in part from this study that provides specific sample conditioning approaches to address pore solution composition, moisture conditioning, and testing procedures. An accelerated aging procedure is discussed to obtain later age properties (91 days) after only 28 days.

This report summarizes discharge and water quality monitoring data for the Snake River and Jackson Lake reservoir levels in Grand Teton National Park and John D. Rockefeller, Jr. Memorial Parkway for calendar year 2016. Annual and long-term discharge summaries and an evaluation of chemical conditions relative to state and federal water quality standards are presented. These results are considered provisional, and may be subject to change. River Discharge: Hydrographs for the Snake River at Flagg Ranch, WY, and Moose, WY, exhibit a general pattern of high early summer flows and lower baseflows occurring in late summer and fall. During much of 2016, flows at the Flagg Ranch monitoring location were similar to the 25th percentile of daily flows at that site. Peak flows at Flagg Ranch were similar to average peak flow from 1983 to 2015 but occurred eleven days earlier in the year compared to the long-term average. Peak flows and daily flows at the Moose monitoring station were below the long-term average. Peak flows occurred four days later than the long-term average. During summer months, the unnatural hydro-graph at the Moose monitoring location exhibited signs of flow regulation associated with the management of Jackson Lake. Water Quality Monitoring in the Snake River: Water quality in the Snake River exhibited seasonal variability over the sampling period. Specifically, total iron peaked during high flows. In contrast, chloride, sulfate, sodium, magnesium, and calcium levels were at their annual minimum during high flows. Jackson Lake Reservoir: Reservoir storage dynamics in Jackson Lake exhibit a pattern of spring filling associated with early snowmelt runoff reaching maximum storage in mid-summer (on or near July 1). During 2016, filling water levels and reservoir storage began to increase in Jackson Lake nearly two weeks earlier than the long-term average and coincident with increases in runoff-driven flows in the Snake River. Although peak storage in Jackson Lake was larger and occurred earlier than the long-term average, minimum storage levels were similar to the long-term average.

Because many patients reduce exercise following outpatient cardiac rehabilitation (CR), we developed an intervention to assist with the transition and evaluated its feasibility and preliminary efficacy using a one-group pretest–posttest design. Five CR patients were enrolled ~1 month prior to CR discharge and provided an activity tracker. Each week during CR they received a summary of their physical activity and steps. Following CR discharge, participants received an individualized report that included their physical activity and step history, information on specific features of the activity tracker, and encouraging messages from former CR patients for each of the next 6 weeks. Mixed model trajectory analyses were used to test the intervention effect separately for active minutes and steps modeling three study phases: pre-intervention (day activity tracking began to CR discharge), intervention (day following CR discharge to day when final report sent), and maintenance (day following the final report to ~1 month later). Activity tracking was successfully deployed and, with weekly reports following CR, may offset the usual decline in physical activity. When weekly reports ceased, a decline in steps/day occurred. A scaled-up intervention with a more rigorous study design with sufficient sample size can evaluate this approach further.

Despite a UN-brokered peace agreement in December 2018, the conflict in Yemen has run into its sixth year. In Taiz Governorate, civilians continue to bear the brunt of conflict. Every day, they face death or injury from indiscriminate attacks, gender-based violence in their homes and poor access to food, water and medical care. As people’s resources are further exhausted, their safety, security and well-being are only likely to worsen. The COVID-19 pandemic has added an additional layer to the ongoing crisis. The people of Taiz –and across Yemen as a whole – desperately need a lasting and inclusive peace process to end the world’s worst humanitarian crisis.

In additive construction, ambitious goals to fabricate a concrete building in less than 24 hours are attempted. In the field, this goal relies on a metric of print time to make this conclusion, which excludes rest time and delays. The task to complete a building in 24 hours was put to the test with the first attempt at a fully continuous print of a structurally reinforced additively constructed concrete (ACC) building. A time series analysis was performed during the construction of a 512 ft2 (16’x32’x9.25’) building to explore the effect of delays on the completion time. This analysis included a study of the variation in comprehensive layer print times, expected trends and forecasting for what is expected in future prints of similar types. Furthermore, the study included a determination and comparison of print time, elapsed time, and construction time, as well as a look at the effect of environmental conditions on the delay events. Upon finishing, the analysis concluded that the 3D-printed building was completed in 14-hours of print time, 31.2- hours elapsed time, a total of 5 days of construction time. This emphasizes that reports on newly 3D-printed constructions need to provide a definition of time that includes all possible duration periods to communicate realistic capabilities of this new technology.

The French composer Francis Poulenc had a profound admiration and empathy for the writings of the Spanish poet Federico García Lorca. That empathy was rooted in shared aspects of the artistic temperament of the two figures but was also undoubtedly reinforced by Poulenc’s fellow-feeling on a human level. As someone who wrestled with his own homosexuality and who kept his orientation and his relationships apart from his public persona, Poulenc would have felt an instinctive affinity for a figure who endured similar internal conflicts but who, especially in his later life and poetry, was more open about his sexuality. Lorca paid a heavy price for this refusal to dissimulate; his arrest in August 1936 and his assassination the following day, probably by Nationalist militia, was accompanied by taunts from his killers about his sexuality. Everything about the Spanish poet’s life, his artistic affinities, his personal predilections and even the relationship between these and his death made him someone to whom Poulenc would be naturally drawn and whose untimely demise he would feel keenly and might wish to commemorate musically. Starting with the death of both his parents while he was still in his teens, reinforced by the sudden loss in 1930 of an especially close friend, confidante and kindred spirit, and continuing throughout the remainder of his life with the periodic loss of close friends, companions and fellow-artists, Poulenc’s life was marked by a succession of bereavements. Significantly, many of the dedications that head up his compositions are ‘to the memory of’ the individual named. As Poulenc grew older, and the list of those whom he had outlived lengthened inexorably, his natural tendency towards the nostalgic and the elegiac fused with a growing sense of what might be termed a ‘survivor’s anguish’, part of which he sublimated into his musical works. It should therefore come as no surprise that, during the 1940s, and in fulfilment of a desire that he had felt since the poet’s death, he should turn to Lorca for inspiration and, in the process, attempt his own act of homage in two separate works: the Violin Sonata and the ‘Trois Chansons de Federico García Lorca’. This exposition attempts to unfold aspects of the two men’s aesthetic pre-occupations and to show how the parallels uncovered cast reciprocal light upon their respective approaches to the creative process. It also examines the network of enfolded associations, musical and autobiographical, which link Poulenc’s two compositions commemorating Lorca, not only to one another but also to a wider circle of the composer’s works, especially his cycle setting poems of Guillaume Apollinaire: ‘Calligrammes’. Composed a year after the ‘Trois Chansons de Federico García Lorca’, this intricately wrought collection of seven mélodies, which Poulenc saw as the culmination of an intensive phase in his activity in this genre, revisits some of ‘unheard voices’ and ‘unseen shadows’ enfolded in its predecessor. It may be viewed, in part, as an attempt to bring to fuller resolution the veiled but keenly-felt anguish invoked by these paradoxical properties.

1.1 Macroeconomic summary Economic recovery has consistently outperformed the technical staff’s expectations following a steep decline in activity in the second quarter of 2020. At the same time, total and core inflation rates have fallen and remain at low levels, suggesting that a significant element of the reactivation of Colombia’s economy has been related to recovery in potential GDP. This would support the technical staff’s diagnosis of weak aggregate demand and ample excess capacity. The most recently available data on 2020 growth suggests a contraction in economic activity of 6.8%, lower than estimates from January’s Monetary Policy Report (-7.2%). High-frequency indicators suggest that economic performance was significantly more dynamic than expected in January, despite mobility restrictions and quarantine measures. This has also come amid declines in total and core inflation, the latter of which was below January projections if controlling for certain relative price changes. This suggests that the unexpected strength of recent growth contains elements of demand, and that excess capacity, while significant, could be lower than previously estimated. Nevertheless, uncertainty over the measurement of excess capacity continues to be unusually high and marked both by variations in the way different economic sectors and spending components have been affected by the pandemic, and by uneven price behavior. The size of excess capacity, and in particular the evolution of the pandemic in forthcoming quarters, constitute substantial risks to the macroeconomic forecast presented in this report. Despite the unexpected strength of the recovery, the technical staff continues to project ample excess capacity that is expected to remain on the forecast horizon, alongside core inflation that will likely remain below the target. Domestic demand remains below 2019 levels amid unusually significant uncertainty over the size of excess capacity in the economy. High national unemployment (14.6% for February 2021) reflects a loose labor market, while observed total and core inflation continue to be below 2%. Inflationary pressures from the exchange rate are expected to continue to be low, with relatively little pass-through on inflation. This would be compatible with a negative output gap. Excess productive capacity and the expectation of core inflation below the 3% target on the forecast horizon provide a basis for an expansive monetary policy posture. The technical staff’s assessment of certain shocks and their expected effects on the economy, as well as the presence of several sources of uncertainty and related assumptions about their potential macroeconomic impacts, remain a feature of this report. The coronavirus pandemic, in particular, continues to affect the public health environment, and the reopening of Colombia’s economy remains incomplete. The technical staff’s assessment is that the COVID-19 shock has affected both aggregate demand and supply, but that the impact on demand has been deeper and more persistent. Given this persistence, the central forecast accounts for a gradual tightening of the output gap in the absence of new waves of contagion, and as vaccination campaigns progress. The central forecast continues to include an expected increase of total and core inflation rates in the second quarter of 2021, alongside the lapse of the temporary price relief measures put in place in 2020. Additional COVID-19 outbreaks (of uncertain duration and intensity) represent a significant risk factor that could affect these projections. Additionally, the forecast continues to include an upward trend in sovereign risk premiums, reflected by higher levels of public debt that in the wake of the pandemic are likely to persist on the forecast horizon, even in the context of a fiscal adjustment. At the same time, the projection accounts for the shortterm effects on private domestic demand from a fiscal adjustment along the lines of the one currently being proposed by the national government. This would be compatible with a gradual recovery of private domestic demand in 2022. The size and characteristics of the fiscal adjustment that is ultimately implemented, as well as the corresponding market response, represent another source of forecast uncertainty. Newly available information offers evidence of the potential for significant changes to the macroeconomic scenario, though without altering the general diagnosis described above. The most recent data on inflation, growth, fiscal policy, and international financial conditions suggests a more dynamic economy than previously expected. However, a third wave of the pandemic has delayed the re-opening of Colombia’s economy and brought with it a deceleration in economic activity. Detailed descriptions of these considerations and subsequent changes to the macroeconomic forecast are presented below. The expected annual decline in GDP (-0.3%) in the first quarter of 2021 appears to have been less pronounced than projected in January (-4.8%). Partial closures in January to address a second wave of COVID-19 appear to have had a less significant negative impact on the economy than previously estimated. This is reflected in figures related to mobility, energy demand, industry and retail sales, foreign trade, commercial transactions from selected banks, and the national statistics agency’s (DANE) economic tracking indicator (ISE). Output is now expected to have declined annually in the first quarter by 0.3%. Private consumption likely continued to recover, registering levels somewhat above those from the previous year, while public consumption likely increased significantly. While a recovery in investment in both housing and in other buildings and structures is expected, overall investment levels in this case likely continued to be low, and gross fixed capital formation is expected to continue to show significant annual declines. Imports likely recovered to again outpace exports, though both are expected to register significant annual declines. Economic activity that outpaced projections, an increase in oil prices and other export products, and an expected increase in public spending this year account for the upward revision to the 2021 growth forecast (from 4.6% with a range between 2% and 6% in January, to 6.0% with a range between 3% and 7% in April). As a result, the output gap is expected to be smaller and to tighten more rapidly than projected in the previous report, though it is still expected to remain in negative territory on the forecast horizon. Wide forecast intervals reflect the fact that the future evolution of the COVID-19 pandemic remains a significant source of uncertainty on these projections. The delay in the recovery of economic activity as a result of the resurgence of COVID-19 in the first quarter appears to have been less significant than projected in the January report. The central forecast scenario expects this improved performance to continue in 2021 alongside increased consumer and business confidence. Low real interest rates and an active credit supply would also support this dynamic, and the overall conditions would be expected to spur a recovery in consumption and investment. Increased growth in public spending and public works based on the national government’s spending plan (Plan Financiero del Gobierno) are other factors to consider. Additionally, an expected recovery in global demand and higher projected prices for oil and coffee would further contribute to improved external revenues and would favor investment, in particular in the oil sector. Given the above, the technical staff’s 2021 growth forecast has been revised upward from 4.6% in January (range from 2% to 6%) to 6.0% in April (range from 3% to 7%). These projections account for the potential for the third wave of COVID-19 to have a larger and more persistent effect on the economy than the previous wave, while also supposing that there will not be any additional significant waves of the pandemic and that mobility restrictions will be relaxed as a result. Economic growth in 2022 is expected to be 3%, with a range between 1% and 5%. This figure would be lower than projected in the January report (3.6% with a range between 2% and 6%), due to a higher base of comparison given the upward revision to expected GDP in 2021. This forecast also takes into account the likely effects on private demand of a fiscal adjustment of the size currently being proposed by the national government, and which would come into effect in 2022. Excess in productive capacity is now expected to be lower than estimated in January but continues to be significant and affected by high levels of uncertainty, as reflected in the wide forecast intervals. The possibility of new waves of the virus (of uncertain intensity and duration) represents a significant downward risk to projected GDP growth, and is signaled by the lower limits of the ranges provided in this report. Inflation (1.51%) and inflation excluding food and regulated items (0.94%) declined in March compared to December, continuing below the 3% target. The decline in inflation in this period was below projections, explained in large part by unanticipated increases in the costs of certain foods (3.92%) and regulated items (1.52%). An increase in international food and shipping prices, increased foreign demand for beef, and specific upward pressures on perishable food supplies appear to explain a lower-than-expected deceleration in the consumer price index (CPI) for foods. An unexpected increase in regulated items prices came amid unanticipated increases in international fuel prices, on some utilities rates, and for regulated education prices. The decline in annual inflation excluding food and regulated items between December and March was in line with projections from January, though this included downward pressure from a significant reduction in telecommunications rates due to the imminent entry of a new operator. When controlling for the effects of this relative price change, inflation excluding food and regulated items exceeds levels forecast in the previous report. Within this indicator of core inflation, the CPI for goods (1.05%) accelerated due to a reversion of the effects of the VAT-free day in November, which was largely accounted for in February, and possibly by the transmission of a recent depreciation of the peso on domestic prices for certain items (electric and household appliances). For their part, services prices decelerated and showed the lowest rate of annual growth (0.89%) among the large consumer baskets in the CPI. Within the services basket, the annual change in rental prices continued to decline, while those services that continue to experience the most significant restrictions on returning to normal operations (tourism, cinemas, nightlife, etc.) continued to register significant price declines. As previously mentioned, telephone rates also fell significantly due to increased competition in the market. Total inflation is expected to continue to be affected by ample excesses in productive capacity for the remainder of 2021 and 2022, though less so than projected in January. As a result, convergence to the inflation target is now expected to be somewhat faster than estimated in the previous report, assuming the absence of significant additional outbreaks of COVID-19. The technical staff’s year-end inflation projections for 2021 and 2022 have increased, suggesting figures around 3% due largely to variation in food and regulated items prices. The projection for inflation excluding food and regulated items also increased, but remains below 3%. Price relief measures on indirect taxes implemented in 2020 are expected to lapse in the second quarter of 2021, generating a one-off effect on prices and temporarily affecting inflation excluding food and regulated items. However, indexation to low levels of past inflation, weak demand, and ample excess productive capacity are expected to keep core inflation below the target, near 2.3% at the end of 2021 (previously 2.1%). The reversion in 2021 of the effects of some price relief measures on utility rates from 2020 should lead to an increase in the CPI for regulated items in the second half of this year. Annual price changes are now expected to be higher than estimated in the January report due to an increased expected path for fuel prices and unanticipated increases in regulated education prices. The projection for the CPI for foods has increased compared to the previous report, taking into account certain factors that were not anticipated in January (a less favorable agricultural cycle, increased pressure from international prices, and transport costs). Given the above, year-end annual inflation for 2021 and 2022 is now expected to be 3% and 2.8%, respectively, which would be above projections from January (2.3% and 2,7%). For its part, expected inflation based on analyst surveys suggests year-end inflation in 2021 and 2022 of 2.8% and 3.1%, respectively. There remains significant uncertainty surrounding the inflation forecasts included in this report due to several factors: 1) the evolution of the pandemic; 2) the difficulty in evaluating the size and persistence of excess productive capacity; 3) the timing and manner in which price relief measures will lapse; and 4) the future behavior of food prices. Projected 2021 growth in foreign demand (4.4% to 5.2%) and the supposed average oil price (USD 53 to USD 61 per Brent benchmark barrel) were both revised upward. An increase in long-term international interest rates has been reflected in a depreciation of the peso and could result in relatively tighter external financial conditions for emerging market economies, including Colombia. Average growth among Colombia’s trade partners was greater than expected in the fourth quarter of 2020. This, together with a sizable fiscal stimulus approved in the United States and the onset of a massive global vaccination campaign, largely explains the projected increase in foreign demand growth in 2021. The resilience of the goods market in the face of global crisis and an expected normalization in international trade are additional factors. These considerations and the expected continuation of a gradual reduction of mobility restrictions abroad suggest that Colombia’s trade partners could grow on average by 5.2% in 2021 and around 3.4% in 2022. The improved prospects for global economic growth have led to an increase in current and expected oil prices. Production interruptions due to a heavy winter, reduced inventories, and increased supply restrictions instituted by producing countries have also contributed to the increase. Meanwhile, market forecasts and recent Federal Reserve pronouncements suggest that the benchmark interest rate in the U.S. will remain stable for the next two years. Nevertheless, a significant increase in public spending in the country has fostered expectations for greater growth and inflation, as well as increased uncertainty over the moment in which a normalization of monetary policy might begin. This has been reflected in an increase in long-term interest rates. In this context, emerging market economies in the region, including Colombia, have registered increases in sovereign risk premiums and long-term domestic interest rates, and a depreciation of local currencies against the dollar. Recent outbreaks of COVID-19 in several of these economies; limits on vaccine supply and the slow pace of immunization campaigns in some countries; a significant increase in public debt; and tensions between the United States and China, among other factors, all add to a high level of uncertainty surrounding interest rate spreads, external financing conditions, and the future performance of risk premiums. The impact that this environment could have on the exchange rate and on domestic financing conditions represent risks to the macroeconomic and monetary policy forecasts. Domestic financial conditions continue to favor recovery in economic activity. The transmission of reductions to the policy interest rate on credit rates has been significant. The banking portfolio continues to recover amid circumstances that have affected both the supply and demand for loans, and in which some credit risks have materialized. Preferential and ordinary commercial interest rates have fallen to a similar degree as the benchmark interest rate. As is generally the case, this transmission has come at a slower pace for consumer credit rates, and has been further delayed in the case of mortgage rates. Commercial credit levels stabilized above pre-pandemic levels in March, following an increase resulting from significant liquidity requirements for businesses in the second quarter of 2020. The consumer credit portfolio continued to recover and has now surpassed February 2020 levels, though overall growth in the portfolio remains low. At the same time, portfolio projections and default indicators have increased, and credit establishment earnings have come down. Despite this, credit disbursements continue to recover and solvency indicators remain well above regulatory minimums. 1.2 Monetary policy decision In its meetings in March and April the BDBR left the benchmark interest rate unchanged at 1.75%.