Relevant bibliographies by topics / Dazap2

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Academic literature on the topic 'Dazap2'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "Dazap2"

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Liebl, Magdalena C., Jutta Moehlenbrink, Huong Becker, Günter Raddatz, Suhaib K. Abdeen, Rami I. Aqeilan, Frank Lyko, and Thomas G. Hofmann. "DAZAP2 acts as specifier of the p53 response to DNA damage." Nucleic Acids Research 49, no. 5 (February 16, 2021): 2759–76. http://dx.doi.org/10.1093/nar/gkab084.

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Abstract The DNA damage-responsive tumor suppressors p53 and HIPK2 are well established regulators of cell fate decision-making and regulate the cellular sensitivity to DNA-damaging drugs. Here, we identify Deleted in Azoospermia-associated protein 2 (DAZAP2), a small adaptor protein, as a novel regulator of HIPK2 and specifier of the DNA damage-induced p53 response. Knock-down or genetic deletion of DAZAP2 strongly potentiates cancer cell chemosensitivity both in cells and in vivo using a mouse tumour xenograft model. In unstressed cells, DAZAP2 stimulates HIPK2 polyubiquitination and degradation through interplay with the ubiquitin ligase SIAH1. Upon DNA damage, HIPK2 site-specifically phosphorylates DAZAP2, which terminates its HIPK2-degrading function and triggers its re-localization to the cell nucleus. Interestingly, nuclear DAZAP2 interacts with p53 and specifies target gene expression through modulating a defined subset of p53 target genes. Furthermore, our results suggest that DAZAP2 co-occupies p53 response elements to specify target gene expression. Collectively, our findings propose DAZAP2 as novel regulator of the DNA damage-induced p53 response that controls cancer cell chemosensitivity.
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Hu, Wei-Xin, Wei Ren, Le-Qi He, Rong Sheng, and Yi-Wu Shi. "Methylation of CpG Islands Was Involved in the Down-Regulation of DAZAP2 in Multiple Meyloma Cells." Blood 110, no. 11 (November 16, 2007): 4157. http://dx.doi.org/10.1182/blood.v110.11.4157.4157.

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Abstract Our previous studies showed that DAZAP2 (deleted in azoospermia associated protein 2) was the most profoundly downregulated gene in bone marrow mononuclear cells from multiple meyloma (MM) patients. The results implicated a role for DAZAP2 as a potential tumor suppressor involved in the origin and development of MM. To further understand the molecular mechanism underlying this deregulation, we analyzed epigenetic changes (i.e., DNA methylation) associated with DAZAP2 in MM, given that aberrant promoter methylation contributes to tumorigenesis through inducing transcriptional suppression and tumor suppressor inactivation. Bioinformatics analysis showed that there are three CpG islands in the DAZAP2 promoter region. The fragments of DAZAP2 promoter region with different length were separately PCR-amplified and inserted into the luciferase reporter, pGL2-Basic vector. The reporter constructs were transfected into COS-7 cells and their luciferase activities measured. The results showed that the fragment containing the third CpG island was the most active among the constructs tested. When this fragment was treated with M. Sss I methylase, its luciferase activity was almost lost. On the other hand, after 5-aza-2′-deoxycytidine treatment, the expression of DAZAP2 was restored in KM3 cells, an MM cell line associated with DAZAP2 downregulation. To extend these observations, bone marrow samples from MM patients and normal controls were collected and genomic DNA, RNA and proteins were extracted from each sample for RT-PCR, MSP (methylation-specific PCR) and Western blot analyses. The results were in general agreement with that reported previously, demonstrating that the protein and mRNA of DAZAP2, while detectable in 100% normal controls, were undetectable in 62.5% MM patients. The MSP data further corroborated with RT-PCR and Western blot analysis (94%), which is characterized by a negative correlation between promoter methylation and downregulation of DAZAP2 in multiple myeloma. These results indicate that promoter hypermethylation may play an important role in downregulation of DAZAP2 gene expression in multiple myeloma.
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Hu, Wei-Xin, Qiang Qu, Jiang Li, and Wei Ren. "Hyper-Methylation DAZAP2 May Suppress Its Expression in Specific Subtypes of Myeloma." Blood 114, no. 22 (November 20, 2009): 4421. http://dx.doi.org/10.1182/blood.v114.22.4421.4421.

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Abstract Abstract 4421 Most malignant features of cancer cells are triggered by activated oncogenes and the loss of tumor suppressors due to mutation or epigenetic inactivation. We previously reported that DAZAP2 was down-regulated in newly diagnosed myeloma (MM) and this may influence MM cell growth and survival. This study was undertaken to evaluate the mechanism of down-regulation DAZAP2 and determine the methylation status and loci of its promoter by using bisulphite genomic-sequencing (BGS) method in KM3 myeloma cell line. Two islands with rich GC box in the promoter of DAZAP2 gene were identified and amplified by using bisulfite-sequencing PCR (BSP). Island 1 spans -472 to -247 including 9 CpG sites (CpGs) and island 2 covers -226 to -13 including 23 CpG sites. The ratio of methylated CpGs in two CpG islands was 46.25%. The above sequences were demethylated and inserted into a pGL2-basic vector. COS-7 cells were transfected with recombinant plasmids and the activity of luciferase was evaluated. The results showed that the CpG island 1 had a weakly transcriptional activity, whereas the CpG island 2 had a strong transcriptional activity (2.38 folds compared with the positive control). The other sequence which covered CpG island 1 and 2 showed a remarkable activity (15.1 folds compared with the positive control). These data indicated that CpG island 2 of DAZAP2 gene may be hypermethylated and suppressed its expression in MM cells. We further correlated DAZAP2 expression with normal plasma cells and malignant myeloma cells, as well as the molecular subtypes which the dataset includes 8 genetic subtypes (MY, PR, LB, MS, HP, CD-1, CD-2, and MF) from 351 newly diagnosed myeloma cases (Zhan, 2006). Interestingly, we extended and confirmed our previous discovery that DAZAP2 was significantly down-regulated in MM cells by using a large uniform dataset (P = 0.004). The low expression of DAZAP2 was especially significant in the subgroups of MY, PR, LB, HP, and CD-1. This study warrants further investigation of DAZAP2 and its potential role in myeloma. Disclosures: No relevant conflicts of interest to declare.
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SHI, Yi-wu, Rong SHEN, Wei REN, Li-jun TANG, Da-ren TAN, and Wei-xin HU. "Molecular features and expression of DAZAP2 in human multiple myeloma." Chinese Medical Journal 120, no. 19 (October 2007): 1659–65. http://dx.doi.org/10.1097/00029330-200710010-00003.

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Lukas, Jan, Petr Mazna, Tomas Valenta, Lenka Doubravska, Vendula Pospichalova, Martina Vojtechova, Bohumil Fafilek, et al. "Dazap2 modulates transcription driven by the Wnt effector TCF-4." Nucleic Acids Research 37, no. 9 (March 20, 2009): 3007–20. http://dx.doi.org/10.1093/nar/gkp179.

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Popova, Anna, Julia Kzhyshkowska, Dinara Nurgazieva, Sergij Goerdt, and Alexei Gratchev. "Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2." Immunobiology 217, no. 3 (March 2012): 321–28. http://dx.doi.org/10.1016/j.imbio.2011.10.004.

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Luo, Sai-Qun, Jing-Ping Hu, Qiang Qu, Jiang Li, Wei Ren, Jia-Ming Zhang, Yan Zhong, and Wei-Xin Hu. "The Effects of Promoter Methylation on Downregulation of DAZAP2 in Multiple Myeloma Cell Lines." PLoS ONE 7, no. 7 (July 9, 2012): e40475. http://dx.doi.org/10.1371/journal.pone.0040475.

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Forbes, Meredyth M., Sophie Rothhämel, Andreas Jenny, and Florence L. Marlow. "RETRACTED: Maternal dazap2 Regulates Germ Granules by Counteracting Dynein in Zebrafish Primordial Germ Cells." Cell Reports 12, no. 1 (July 2015): 49–57. http://dx.doi.org/10.1016/j.celrep.2015.06.010.

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Zepp, Jarod A., Ling Wu, Wen Qian, Wenjun Ouyang, Mark Aronica, Serpil Erzurum, and Xiaoxia Li. "TRAF4-SMURF2–Mediated DAZAP2 Degradation Is Critical for IL-25 Signaling and Allergic Airway Inflammation." Journal of Immunology 194, no. 6 (February 13, 2015): 2826–37. http://dx.doi.org/10.4049/jimmunol.1402647.

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Roche, Daniel D., Karen J. Liu, Richard M. Harland, and Anne H. Monsoro-Burq. "Dazap2 is required for FGF-mediated posterior neural patterning, independent of Wnt and Cdx function." Developmental Biology 333, no. 1 (September 2009): 26–36. http://dx.doi.org/10.1016/j.ydbio.2009.06.019.

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Dissertations / Theses on the topic "Dazap2"

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Cox, Jamie Walden. "Dazai's Women: Dazai Osamu and his Female Narrators." PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/132.

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Dazai Osamu (born Tsushima Shûji) was a post-WWII writer who wrote a number of works using a female narrator. This thesis research focused on the reasons as to why Dazai may have written using female narratives, taking into consideration the time period and social milieu in which he was writing, as well as his own personal history with women. In addition, the history of male authors utilizing female narratives was explored, as well as the ideas of gender in the Japanese arts. Dazai works were also compared with Tankizaki Junichirô's to see how the roles of women in their works differ. The four main Dazai works analyzed were "Magic Lanterns" ("Tôrô"), "The Schoolgirl" ("Joseito"), "December 8th" ("Jûnigatsu yôka"), and "Villon's Wife" ("Biyon no tsuma"). The conclusion was that Dazai was using female narrators as a different approach to further critiquing himself, with the female narrator being used to critique a Dazai-like persona in the works.
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Lubitz, Joseph B. "Anxious Seas: Reading Affect in Dazai and Murdoch." Oberlin College Honors Theses / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=oberlin1451406893.

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Nagaike, Kazumi. "Dazai Osamu's Otogi zoshi, a structural and narratological analysis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq22546.pdf.

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Lavelle, Isabelle. "Littérature et imposture : Identités narratives chez Dazai Osamu (1909-1948)." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC031.

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Toute l'oeuvre de l'écrivain japonais Dazai Osamu est au service d'une création de soi autoréflexive. Brouillant jusqu'à l'extrême les limites entre personne et personnage, sa littérature construit une figure auctoriale qui affirme sa légitimité en mettant constamment en question les codes de la fiction. Cette thèse aborde les multiples incarnations de « Dazai Osamu » à travers sa posture, concept qui permet de réunir la conduite et l'ethos par lesquels le personnage auctorial se met en scène. Celui-ci est ainsi abordé à travers son positionnement par rapport aux discours de son temps. L'identité chez Dazai s'élabore en effet en fonction des perceptions d'autrui : l'auteur n'existe que pour répondre aux attentes dont il fait l'objet. La posture conçue comme imposture débouche alors sur une quête existentielle qui interroge sa légitimité à être humain
Japanese writer Dazai Osamu's literature can be seen as an experiment in self¬creation. Through the use of metafictional reflexivity, the author states his legitimacy as a person made character by constantly challenging the rules of fiction. Dazai creates his identity as a mere reflection of the perceptions of himself he anticipates within the other's gaze. This thesis aims to analyze how "Dazai Osamu" emerges through multiple narrative incarnations by focusing on the notion of posture. Understood as the way an author positions him/herself within the discursive flux of his/her time, the notion allows us to consider the behavioral and linguistic elements which constitute literary self-representation as a whole. Within Dazai's literature, the "author" being only the sum of discourses held about him, posture is apprehended as imposture. His works reflect an existential quest about the meaning of being human
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Jiménez, Benito Javier. "Daza de Valdés en la oftalmología." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/120551.

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Benito Daza de Valdés (1591-1634) fue un notable científico español que publicó en 1623 el libro “Uso de los Antojos” que es considerado el primer tratado de óptica fisiológica en el mundo. La refracción ha permitido mejorar la calidad de vida de millones de personas siendo las gafas la prótesis sanitaria más utilizada en el mundo y en este extraordinario invento Daza de Valdés ha sido una personalidad señera. Esta tesis reivindica el importante papel que ha desempeñado la óptica fisiológica en el desarrollo de la oftalmología y considera la refracción ocular como parte fundamental la oftalmología. En esta tesis se exponen las teorías de la visión desde la Antigüedad hasta el siglo XVII con especial dedicación a los autores citados en el libro Uso de los Antojos. También se presenta una breve historia de las gafas, se analiza el contexto histórico y cultural del tiempo de Daza de Valdés así como su biografía y un estudio exhaustivo del libro Uso de los Antojos. Las aportaciones más importantes en relación a la óptica fisiológica son: introducir el concepto de inversa de la distancia focal en la medición de los cristales refractivos que denominó grados (similar a la actual dioptría), hacer la primera descripción clínica de la hipermetropía, pionero en presentar el agujero estenopeico incorporado a las gafas, sistematizar la prescripción de gafas y la acertada idea que las gafas o antojos sólo sirven para las ametropías y que no pueden solucionar patologías oculares. Esta tesis también incluye un apéndice documental con las portadas de los libros citados en el libro Uso de los Antojos, las portadas de los libros que posiblemente consultó Daza de Valdés, una muestra de los cuadros y grabados en los que aparecen gafas hasta el siglo XVII, el primer documento escrito (1370) dónde se cita la palabra gafa (occhiali en italiano) y también copia de una carta del rey Felipe II pidiendo gafas de 1584.
Benito Daza de Valdés (1591-1634) was an outstanding Spanish scientist that in 1623 published the book titled “The use of Spectacles” (“Uso de los Antojos”), considered the first treaty on physiological optics ever written. Clinical refraction has been instrumental in improving the quality of life of millions of people and spectacles are the prosthetic aid most used in the world. Daza Valdes was instrumental to this extraordinary invention. This thesis vindicates the role that physiological optics has had in the development of Ophthalmology and proposes clinical refraction as a fundamental part of this discipline. This work discusses the different theories of vision from Antiquity to the 17th century with a focus on the authors cited in the book The use of Spectacles. It also provides a brief history of spectacles and analyses the historical and cultural context during Daza Valdes’s lifetime, his biography and provides an in depth study of his book The use of Spectacles. Daza’s book made some remarkable contributions to physiological optics. Amongst the most visionary are: Daza’s introduction of the concept of the inverse of the focal distance in the measurement of refractive lenses, which he called degrees and are a equivalent to the current dioptre; he described clinical hypermetropia for the first time; he pioneered the introduction of the stenopeic pin–hole in spectacles; he proposed the systematic prescription for spectacles and he correctly proposed that spectacles are only useful for correcting ametropia and do not remedy other ocular pathology. Included in this thesis is a documentary appendix including: the front covers of all the books quoted by Daza in his work The use of Spectacles, and of those books that he probably consulted; a selection of paintings and engravings depicting spectacles up to the 17th century; a copy of the first document from 1370 where the word spectacles is first cited (occhiali in Italian) and a copy of a letter from King Philip II of Spain requesting spectacles in 1584.
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Kawana, Karen Kazue. "Reflexões sobre a mulher no Japão e nos textos de Osamu Dazai." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/8/8157/tde-10032016-131544/.

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Osamu Dazai é um dos poucos escritores japoneses da primeira metade do século XX que emprega mulheres como narradoras. Procuramos explorar essa peculiaridade de seus textos comparando-os, embora brevemente, com aqueles de alguns de seus contemporâneos, como Yasunari Kawabata e Junichirô Tanizaki. Fazemos algumas incursões na ideia de feminilidade que permeava a sociedade japonesa no início do século XX e as transformações que ela sofre até o final da Segunda Guerra, pois acreditamos que essas mesmas mudanças na imagem do feminino também sejam refletidas pelos textos de Dazai. Analisamos alguns de seus textos com narradoras para observar o quanto elas se distanciam ou se aproximam dos ideais de feminilidade da sociedade da época. Por fim, também comparamos as figuras femininas de suas obras do pós-guerra com suas figuras masculinas, estas, muito parecidas com o próprio autor, presas do niilismo e em rota de autodestruição. Nossa intenção, em suma, é explorar, mesmo que de forma limitada, as relações entre a cultura da época e a literatura por meio da análise de alguns textos com narradoras de Osamu Dazai, bem como sublinhar o caráter peculiar dessas mesmas narradoras no interior das obras do autor e em relação aos textos de seus contemporâneos.
Osamu Dazai is one of the few Japanese writers from the first half of the 20th century in whose texts we find female narrators. We intend to explore, although briefly, this peculiarity comparing his texts with those written by authors like Yasunari Kawabata and Junichirô Tanizaki. We make some incursions into the idea of womanliness which permeated the Japanese society in the beginning of the 20th century and the changes which it undergoes until the end of the Second World War because we believe that the same changes in the female image are reflected in Dazais texts. We analyze some of his texts with female narrators to see how far or close they are to societys ideals of womanliness. Lastly, we compare the female characters of Dazais postwar texts with the male ones (who resemble the author himself in their nihilism and self-destructive tendencies). In short, our objective is to examine, even if not as comprehensively as we could wish, how the culture of the period and the literature are related by analyzing some texts with female narrators written by Osamu Dazai. We also hope to stress the uniqueness of these female narrators within the authors texts and in relation to those of his contemporaries.
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Silva, Hiroko Hashimoto da. "A estética do espaço na obra Pôr-do-Sol, de Dazai Osamu." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/8/8157/tde-31082010-143013/.

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Esta pesquisa visa analisar a estética do espaço e a estética literária empregadas na narrativa da obra Pôr-do-Sol, de Dazai Osamu, bem como resgatar a essência da cultura japonesa contemporânea de um Japão devastado pela Segunda Guerra Mundial, onde o autor expressa toda a sua sensibilidade poética. Este trabalho baseia-se na pesquisa biográfica de Dazai Osamu, com ênfase ao momento histórico que o autor testemunhou e onde realizou suas escritas, visando o levantamento da iconografia, pictografia e metonímia na linguagem de sua obra. Através deste estudo buscam-se os elementos que o enquadrem no gênero literário denominado Romance do Eu e as influências exercidas pelo Naturalismo europeu e movimentos sociais em sua carreira literária por meio da análise da hereditariedade, das influências do meio social no ambiente da obra e a estética literária empregada em sua técnica narrativa. O estudo desenvolvido demonstra as interferências ocidentais na Literatura Japonesa através da intertextualidade de obras japonesas e ocidentais, que dialogam entre si, e apresentam uma narrativa ao redor da estética do espaço na obra Pôr-do-Sol, retratando a essência humana, o irracional, as emoções, o onírico, as alegrias e desilusões inerentes a todos os seres humanos, principalmente na sociedade japonesa do período histórico do pós-guerra.
This research seeks analyze Dazai Osamu\'s spatial aesthetics and his literary style, which was used in his novel Setting Sun, besides to bring off essence of Japan Contemporary Culture, that was devastated in this country due to World War II. Another point of this study is the narrative aesthetics, where the writer expresses his poetic sensitiveness. This study is based on Dazai Osamu\'s autobiographic research, emphasizing a historical moment of Japan, which he witnessed and finished his writings despite of war; in his novel, Dazai aimed the language of: iconography survey, pictorial survey and metonymy language. This study will search for elements that fit in the literary genre named I Novel, as well as influences the writer suffered from European Naturalism and social movements in his literary carrier; Dazai analyzed the heredity and the influences of social means described in atmosphere of his work and the literary aesthetic (spatial) carried out in his narrative techniques. The study developed here points out western interference in Japanese literature, which can be noticed in the inter-textuality of literary works between west and east, that inter-act itself; therefore introduces a narrative related to spatial aesthetic in the Setting Sun which the writer describes the essence of human beings´nature such as: irrational feelings, the emotions, the day-dreams, the cheerfulness and disappointments, inherent in whole human beings, especially in the Japanese society in certain historical time after war.
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Nagae, Neide Hissae. "De Katai a Dazai: apontamentos para uma morfologia do romance do eu." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/8/8151/tde-14052007-151503/.

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O presente trabalho constitui um estudo sobre um conjunto de obras pertencentes ao gênero japonês de cunho autobiográfico denominado Romance do Eu, com o intuito de traçar características comuns a essas obras que sirvam como apontamentos para uma morfologia desse gênero surgido no início do século XX. Num primeiro momento, situamos o Romance do Eu no contexto histórico-literário do Japão e apresentamos as discussões de estudiosos japoneses na fase inicial de desenvolvimento dessa forma literária, além da visão de dois estudiosos estrangeiros sobre o gênero. Nesse percurso, traçamos ligações entre as obras estudadas com a repressão ideológica e o exercício da liberdade de expressão na postura acuada e resignada dos protagonistas, encontradas num conjunto de obras analisadas num segundo momento, que vão desde 1906, com a obra Futon (Acolchoado), de Tayama Katai, até o final da Segunda Guerra Mundial. Tais obras revelaram uma sensível e rica diversidade quando analisadas pelos elementos da narrativa que estruturam o texto, mas não foi possível encontrar textualmente aspectos que identificassem o protagonista da obra com seu autor. Na realidade, elas se mostraram uma forma velada de contestação ao sistema autoritário do Japão ao centrarem seu conteúdo em fatos da vida pessoal do autor e parodiarem os romances europeus introduzidos na época. Esse dialogismo do Romance do Eu desenvolve-se também no nível textual da obra de Dazai Osamu, intitulada Pôr-do-Sol, escrita em 1947, logo após a rendição do Japão e ainda sob a ocupação das tropas norte-americanas, incumbidas de iniciar a democratização do país. O estudo desenvolvido nesse terceiro momento mostra que o autor utiliza, ainda, outras formas literárias que privilegiaram a ficção na literatura japonesa, elabora personagens que são desdobramentos de si mesmo e que dialogam entre si e faz uso de diferentes formas narrativas, que se mesclam à intertextualidade de obras japonesas e ocidentais, criando, assim, uma obra que dispensa o rótulo de Romance do Eu e assegura a sobrevivência dessa forma narrativa na prosa moderna do Japão.
ABSTRACT From Katai to Dazai: Notes for Morphology of the Novel of the Self consists of a study on a set of literary works belonging to the autobiographical character Japanese genre denominated Novel of the Self, aiming at outlining common characteristics to these works that serve as notes for a morphology of this genre started in the beginning of the XX century. In a first instance the Novel of the Self is placed in the Japanese historical-literary context and the discussions of Japanese scholars in the initial development phase of this literary form are presented, as well as the vision of two foreign scholars about the genre. In this trajectory are outlined connections of the works studied with the ideological repression and the exercise of the freedom of expression in the cornered and acquiescent posture of protagonists, being these connections found in a set of works analyzed in a second instance, comprehending 1906 with the work of Futon (Quilt) by Tayama Katai, up to the end of the Second World War. Such works have revealed an insightful and rich diversity when analyzed by the elements of the narrative which structure the text, but aspects that could identify the work?s protagonist with its author have not been possible to find textually. As a matter of fact, they have revealed a veiled way of contest to the Japan?s authoritative way as they have focused their content on facts of the author?s personal life and parodied the European novels introduced at that time. This dialogism in the Novel of the Self is also developed on the textual level of the work of Dazai Osamu entitled Sunset, written in 1947, right after the surrender of Japan while under the occupation of the American troops charged with the task of beginning the country?s democratization. The study developed in this third instance reveals that the author uses, in addition, other literary forms that benefit the fiction in the Japanese literature, makes up characters that are developments of himself and that also talk among themselves, and makes use of different forms of narratives that merge to the intertextuality of Japanese and Western works, creating, as a result, a work that excuses the label of Novel of the Self and, assures the endurance of this narrative form in the Japans modern prose.
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Nielsen, Oskar. "Dazai på svenska : En kommenterad översättning av novellerna 走れメロス – Hashire Merosu (”Spring, Moerus!”) och 富嶽百景 – Fugaku Hyakkei (”Hundra vyer över Fuji”) av Osamu Dazai." Thesis, Stockholms universitet, Tolk- och översättarinstitutet, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-117809.

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Denna uppsats består av två översättningar av den japanska författaren Osamu Dazais noveller Spring, Moerus! och Hundra vyer över Fuji från japanska till svenska samt en analys som ur ett litteratur-vetenskapligt perspektiv hjälper till att fastställa översättningsstrategin – att göra en adekvansinriktad och främmandegörande översättning. Översättningarna följs av en översättningsteoretisk kommentar som fokuserar på de tre problemområdena grammatik och lexikon, menings- och styckesstruktur samt passivering. Ett litteraturvetenskapligt perspektiv för källtextanalysen visar sig vara mycket tillämpbart för dessa texter på grund av deras genre, jag-romanen, som är typisk för japansk 1900-talslitteratur. Källtexterna och måltexterna finns med som bilagor.
This essay consists of two translations of the two Japanese short stories Hashire Merosu and Fugaku Hyakkei (in Swedish Spring Moerus! and Hundra vyer över Fuji) by the author Osamu Dazai from Japanese to Swedish. An analysis through a literary science perspective helps to establish the translation strategy, which is to make an adequate and foreignized translation. The translations are followed by a theoretical translation annotation which focuses on the issues of grammar and lexicon, sentence and paragraph structure along with the usage of the passive form. A literary science perspective on the source text analysis proves to be very applicable for these texts because of their genre, the I-novel, which is typical for 20th century Japanese literature. The source and target texts are available as appendixes at the end of the essay.
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10

Rutley, Nicholas. "Molecular control of Arabidopsis male germline development by DAZ1 and DAZ2." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/33356.

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The male germline of flowering plants is a simple lineage of two cell types: generative (germ) cell and sperm cells. An asymmetric division of the microspore during pollen (male gametophyte) development produces the germ cell, which goes on to divide to form a pair of sperm that later fuse with egg and central cells at double fertilisation. The production of functional sperm cells depends upon cell cycle progression and cell specification, and three regulatory proteins – the MYB transcription factor DUO1, and the C2H2 zinc finger proteins DAZ1 and DAZ2 - acting in a gene network have been identified in Arabidopsis to be essential for both of these processes. Expression of DAZ1/DAZ2 is triggered by DUO1, and DAZ1/DAZ2 show functional redundancy. Understanding the mechanisms by which DAZ1 and DAZ2 control male germline development was a major aim of this thesis. The first objective was to explore sequence diversity among DAZ1/DAZ2 flowering plant homologues. This study established that the number of zinc finger domains differed between species, and mutating the zinc finger domains of DAZ1 had different effects on DAZ1 function. Functional analysis of DAZ1 EAR motifs showed that these sequences are important for in planta activity. DAZ1 and DAZ2 interact with the transcriptional co-repressor TPL, and a second objective was to investigate the spatiotemporal expression pattern of TPL and its family members in pollen, with male germline expression was observed for TPL and TPR2. The final objective was to identify genes under the regulation of DAZ1/DAZ2. While DAZ1 was predicted to be a transcriptional repressor, through transcriptomics it was revealed that a broad suite of genes were positively regulated by DAZ1, overlapping with targets of DUO1. The findings communicated in this thesis provide new insights into the molecular mechanisms controlling male germline development.
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Books on the topic "Dazap2"

1

Anarchie et cohésion sociale chez les Toubou: Les Daza Kéšerda (Niger). Cambridge [Cambridgeshire]: Cambridge University Press, 1985.

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Voyages et conversation en pays toubou. Paris: L'Harmattan, 2011.

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Bodoumi, M. Ahmat Saleh. Voyages et conversation en pays toubou. Paris: L'Harmattan, 2011.

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Haggar, Inouss. Dazaga karantaa: Lisons le tubu (dazaga). Niamey: SIL Niger, 2004.

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Dazai, Osamu. Dazai Osamu. Tōkyō: Chikuma Shobō, 1991.

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Dazai Osamu. Tōkyō: Iwanami Shoten, 1998.

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Dazai, Osamu. Dazai Osamu. Tōkyō: Nihon Tosho Sentā, 1996.

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Gakkai, Nihon Rekishi, ed. Dazai Shundai. Tōkyō: Yoshikawa Kōbunkan, 1997.

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Niger, SIL. [SIL Niger publications in Dazaga language]. Niamey, Niger: SIL Niger, 2004.

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Zûgula tirkaa: Yôa ada na ngimire. N'Daména, Tchad: Editions Al-Mouna, 2011.

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Book chapters on the topic "Dazap2"

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Königsberg, Matthew. "Dazai Osamu." In Kindlers Literatur Lexikon (KLL), 1. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_2109-1.

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Naumann, Nelly. "Dazai Osamu: Shayō." In Kindlers Literatur Lexikon (KLL), 1. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_2110-1.

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Lolo, Begoña. "Esteban Daza." In Barockmusikführer, 138–39. Stuttgart: J.B. Metzler, 2001. http://dx.doi.org/10.1007/978-3-476-99520-9_31.

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De Boissieu, Michel. "Le Mont crépitant commenté par Dazai Osamu." In Pragmatique du commentaire, 157–70. Turnhout, Belgium: Brepols Publishers, 2018. http://dx.doi.org/10.1484/j.ash.5.114316.

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Qiu, Panbo, and Mingsan Miao. "Ziziphus jujuba Mill. 大枣 (Dazao, Common Jujube)." In Dietary Chinese Herbs, 561–67. Vienna: Springer Vienna, 2015. http://dx.doi.org/10.1007/978-3-211-99448-1_64.

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Flueckiger, Peter. "Human Nature and the Way in the Philosophy of Dazai Shundai." In Dao Companion to Japanese Confucian Philosophy, 215–32. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-90-481-2921-8_8.

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"Preliminary Material." In A Grammar of Dazaga, i—xvii. BRILL, 2016. http://dx.doi.org/10.1163/9789004323919_001.

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"2 Literature Review." In A Grammar of Dazaga, 10–14. BRILL, 2016. http://dx.doi.org/10.1163/9789004323919_003.

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"3 Phonology." In A Grammar of Dazaga, 15–39. BRILL, 2016. http://dx.doi.org/10.1163/9789004323919_004.

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"5 Verbs." In A Grammar of Dazaga, 64–107. BRILL, 2016. http://dx.doi.org/10.1163/9789004323919_006.

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Conference papers on the topic "Dazap2"

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Greiser, J., C. Kühnel, T. Niksch, W. Weigand, and M. Freesmeyer. "N,1,4-Tri(4-alkoxy-2-hydroxybenzyl)-DAZA: Efficient one-pot synthesis and labelling with 68Ga for PET liver imaging in ovo." In NuklearMedizin 2019. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1683564.

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Reports on the topic "Dazap2"

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Cox, Jamie. Dazai's Women: Dazai Osamu and his Female Narrators. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.132.

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Anolis urraoi Grisales-Martínez, Velasco, Bolívar, Williams - Daza, 2017. Universidad de La Salle, May 2020. http://dx.doi.org/10.19052/mls_1480anolis_urraoi.

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Anolis urraoi Grisales-Martínez, Velasco, Bolívar, Williams - Daza, 2017. Universidad de La Salle, May 2020. http://dx.doi.org/10.19052/mls_1481anolis_urraoi.

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