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Journal articles on the topic 'Dazap2'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Liebl, Magdalena C., Jutta Moehlenbrink, Huong Becker, Günter Raddatz, Suhaib K. Abdeen, Rami I. Aqeilan, Frank Lyko, and Thomas G. Hofmann. "DAZAP2 acts as specifier of the p53 response to DNA damage." Nucleic Acids Research 49, no. 5 (February 16, 2021): 2759–76. http://dx.doi.org/10.1093/nar/gkab084.

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Abstract The DNA damage-responsive tumor suppressors p53 and HIPK2 are well established regulators of cell fate decision-making and regulate the cellular sensitivity to DNA-damaging drugs. Here, we identify Deleted in Azoospermia-associated protein 2 (DAZAP2), a small adaptor protein, as a novel regulator of HIPK2 and specifier of the DNA damage-induced p53 response. Knock-down or genetic deletion of DAZAP2 strongly potentiates cancer cell chemosensitivity both in cells and in vivo using a mouse tumour xenograft model. In unstressed cells, DAZAP2 stimulates HIPK2 polyubiquitination and degradation through interplay with the ubiquitin ligase SIAH1. Upon DNA damage, HIPK2 site-specifically phosphorylates DAZAP2, which terminates its HIPK2-degrading function and triggers its re-localization to the cell nucleus. Interestingly, nuclear DAZAP2 interacts with p53 and specifies target gene expression through modulating a defined subset of p53 target genes. Furthermore, our results suggest that DAZAP2 co-occupies p53 response elements to specify target gene expression. Collectively, our findings propose DAZAP2 as novel regulator of the DNA damage-induced p53 response that controls cancer cell chemosensitivity.

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2

Hu, Wei-Xin, Wei Ren, Le-Qi He, Rong Sheng, and Yi-Wu Shi. "Methylation of CpG Islands Was Involved in the Down-Regulation of DAZAP2 in Multiple Meyloma Cells." Blood 110, no. 11 (November 16, 2007): 4157. http://dx.doi.org/10.1182/blood.v110.11.4157.4157.

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Abstract Our previous studies showed that DAZAP2 (deleted in azoospermia associated protein 2) was the most profoundly downregulated gene in bone marrow mononuclear cells from multiple meyloma (MM) patients. The results implicated a role for DAZAP2 as a potential tumor suppressor involved in the origin and development of MM. To further understand the molecular mechanism underlying this deregulation, we analyzed epigenetic changes (i.e., DNA methylation) associated with DAZAP2 in MM, given that aberrant promoter methylation contributes to tumorigenesis through inducing transcriptional suppression and tumor suppressor inactivation. Bioinformatics analysis showed that there are three CpG islands in the DAZAP2 promoter region. The fragments of DAZAP2 promoter region with different length were separately PCR-amplified and inserted into the luciferase reporter, pGL2-Basic vector. The reporter constructs were transfected into COS-7 cells and their luciferase activities measured. The results showed that the fragment containing the third CpG island was the most active among the constructs tested. When this fragment was treated with M. Sss I methylase, its luciferase activity was almost lost. On the other hand, after 5-aza-2′-deoxycytidine treatment, the expression of DAZAP2 was restored in KM3 cells, an MM cell line associated with DAZAP2 downregulation. To extend these observations, bone marrow samples from MM patients and normal controls were collected and genomic DNA, RNA and proteins were extracted from each sample for RT-PCR, MSP (methylation-specific PCR) and Western blot analyses. The results were in general agreement with that reported previously, demonstrating that the protein and mRNA of DAZAP2, while detectable in 100% normal controls, were undetectable in 62.5% MM patients. The MSP data further corroborated with RT-PCR and Western blot analysis (94%), which is characterized by a negative correlation between promoter methylation and downregulation of DAZAP2 in multiple myeloma. These results indicate that promoter hypermethylation may play an important role in downregulation of DAZAP2 gene expression in multiple myeloma.

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3

Hu, Wei-Xin, Qiang Qu, Jiang Li, and Wei Ren. "Hyper-Methylation DAZAP2 May Suppress Its Expression in Specific Subtypes of Myeloma." Blood 114, no. 22 (November 20, 2009): 4421. http://dx.doi.org/10.1182/blood.v114.22.4421.4421.

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Abstract Abstract 4421 Most malignant features of cancer cells are triggered by activated oncogenes and the loss of tumor suppressors due to mutation or epigenetic inactivation. We previously reported that DAZAP2 was down-regulated in newly diagnosed myeloma (MM) and this may influence MM cell growth and survival. This study was undertaken to evaluate the mechanism of down-regulation DAZAP2 and determine the methylation status and loci of its promoter by using bisulphite genomic-sequencing (BGS) method in KM3 myeloma cell line. Two islands with rich GC box in the promoter of DAZAP2 gene were identified and amplified by using bisulfite-sequencing PCR (BSP). Island 1 spans -472 to -247 including 9 CpG sites (CpGs) and island 2 covers -226 to -13 including 23 CpG sites. The ratio of methylated CpGs in two CpG islands was 46.25%. The above sequences were demethylated and inserted into a pGL2-basic vector. COS-7 cells were transfected with recombinant plasmids and the activity of luciferase was evaluated. The results showed that the CpG island 1 had a weakly transcriptional activity, whereas the CpG island 2 had a strong transcriptional activity (2.38 folds compared with the positive control). The other sequence which covered CpG island 1 and 2 showed a remarkable activity (15.1 folds compared with the positive control). These data indicated that CpG island 2 of DAZAP2 gene may be hypermethylated and suppressed its expression in MM cells. We further correlated DAZAP2 expression with normal plasma cells and malignant myeloma cells, as well as the molecular subtypes which the dataset includes 8 genetic subtypes (MY, PR, LB, MS, HP, CD-1, CD-2, and MF) from 351 newly diagnosed myeloma cases (Zhan, 2006). Interestingly, we extended and confirmed our previous discovery that DAZAP2 was significantly down-regulated in MM cells by using a large uniform dataset (P = 0.004). The low expression of DAZAP2 was especially significant in the subgroups of MY, PR, LB, HP, and CD-1. This study warrants further investigation of DAZAP2 and its potential role in myeloma. Disclosures: No relevant conflicts of interest to declare.

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4

SHI, Yi-wu, Rong SHEN, Wei REN, Li-jun TANG, Da-ren TAN, and Wei-xin HU. "Molecular features and expression of DAZAP2 in human multiple myeloma." Chinese Medical Journal 120, no. 19 (October 2007): 1659–65. http://dx.doi.org/10.1097/00029330-200710010-00003.

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5

Lukas, Jan, Petr Mazna, Tomas Valenta, Lenka Doubravska, Vendula Pospichalova, Martina Vojtechova, Bohumil Fafilek, et al. "Dazap2 modulates transcription driven by the Wnt effector TCF-4." Nucleic Acids Research 37, no. 9 (March 20, 2009): 3007–20. http://dx.doi.org/10.1093/nar/gkp179.

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6

Popova, Anna, Julia Kzhyshkowska, Dinara Nurgazieva, Sergij Goerdt, and Alexei Gratchev. "Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2." Immunobiology 217, no. 3 (March 2012): 321–28. http://dx.doi.org/10.1016/j.imbio.2011.10.004.

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7

Luo, Sai-Qun, Jing-Ping Hu, Qiang Qu, Jiang Li, Wei Ren, Jia-Ming Zhang, Yan Zhong, and Wei-Xin Hu. "The Effects of Promoter Methylation on Downregulation of DAZAP2 in Multiple Myeloma Cell Lines." PLoS ONE 7, no. 7 (July 9, 2012): e40475. http://dx.doi.org/10.1371/journal.pone.0040475.

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8

Forbes, Meredyth M., Sophie Rothhämel, Andreas Jenny, and Florence L. Marlow. "RETRACTED: Maternal dazap2 Regulates Germ Granules by Counteracting Dynein in Zebrafish Primordial Germ Cells." Cell Reports 12, no. 1 (July 2015): 49–57. http://dx.doi.org/10.1016/j.celrep.2015.06.010.

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9

Zepp, Jarod A., Ling Wu, Wen Qian, Wenjun Ouyang, Mark Aronica, Serpil Erzurum, and Xiaoxia Li. "TRAF4-SMURF2–Mediated DAZAP2 Degradation Is Critical for IL-25 Signaling and Allergic Airway Inflammation." Journal of Immunology 194, no. 6 (February 13, 2015): 2826–37. http://dx.doi.org/10.4049/jimmunol.1402647.

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10

Roche, Daniel D., Karen J. Liu, Richard M. Harland, and Anne H. Monsoro-Burq. "Dazap2 is required for FGF-mediated posterior neural patterning, independent of Wnt and Cdx function." Developmental Biology 333, no. 1 (September 2009): 26–36. http://dx.doi.org/10.1016/j.ydbio.2009.06.019.

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11

Shi, Yiwu, Saiqun Luo, Jianbin Peng, Chenghan Huang, Daren Tan, and Weixin Hu. "The Structure, Expression, and Function Prediction of DAZAP2, A Down-Regulated Gene in Multiple Myeloma." Genomics, Proteomics & Bioinformatics 2, no. 1 (February 2004): 47–54. http://dx.doi.org/10.1016/s1672-0229(04)02007-8.

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12

Forbes, Meredyth M., Sophie Rothhämel, Andreas Jenny, and Florence L. Marlow. "Retraction Notice to: Maternal dazap2 Regulates Germ Granules by Counteracting Dynein in Zebrafish Primordial Germ Cells." Cell Reports 15, no. 4 (April 2016): 909. http://dx.doi.org/10.1016/j.celrep.2016.04.030.

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13

Roche, Daniel, Karen Liu, Richard Harland, and Anne-Helene Monsoro-Burq. "13-P117 Dazap2, a novel cdx-independent posteriorizing factor, is required for FGF activity in neural patterning." Mechanisms of Development 126 (August 2009): S230. http://dx.doi.org/10.1016/j.mod.2009.06.590.

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14

Sugawara, Tohru, Takumi Miura, Tomoyuki Kawasaki, Akihiro Umezawa, and Hidenori Akutsu. "The hsa-miR-302 cluster controls ectodermal differentiation of human pluripotent stem cell via repression of DAZAP2." Regenerative Therapy 15 (December 2020): 1–9. http://dx.doi.org/10.1016/j.reth.2020.03.011.

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15

Li, Jiang, Wei-Xin Hu, Sai-Qun Luo, De-Hui Xiong, Shuming Sun, Yan-Peng Wang, Xiu-Fen Bu, Jing Liu, and Jingping Hu. "Promoter methylation induced epigenetic silencing of DAZAP2, a downstream effector of p38/MAPK pathway, in multiple myeloma cells." Cellular Signalling 60 (August 2019): 136–45. http://dx.doi.org/10.1016/j.cellsig.2019.04.012.

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16

Luo, Tian, and Jere W. McBride. "Ehrlichia chaffeensis TRP32 Interacts with Host Cell Targets That Influence Intracellular Survival." Infection and Immunity 80, no. 7 (April 30, 2012): 2297–306. http://dx.doi.org/10.1128/iai.00154-12.

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ABSTRACTEhrlichia chaffeensisis an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes and survives by evading host cell defense mechanisms. Recently, molecular interactions ofE. chaffeensistandem repeat proteins 47 and 120 (TRP47 and -120) and the eukaryotic host cell have been described. In this investigation, yeast two-hybrid analysis demonstrated that anE. chaffeensistype 1 secretion system substrate, TRP32, interacts with a diverse group of human proteins associated with major biological processes of the host cell, including protein synthesis, trafficking, degradation, immune signaling, cell signaling, iron metabolism, and apoptosis. Eight target proteins, including translation elongation factor 1 alpha 1 (EF1A1), deleted in azoospermia (DAZ)-associated protein 2 (DAZAP2), ferritin light polypeptide (FTL), CD63, CD14, proteasome subunit beta type 1 (PSMB1), ring finger and CCCH-type domain 1 (RC3H1), and tumor protein p53-inducible protein 11 (TP53I11) interacted with TRP32 as determined by coimmunoprecipitation assays, colocalization with TRP32 in HeLa and THP-1 cells, and/or RNA interference. Interactions between TRP32 and host targets localized to theE. chaffeensismorulae or in the host cell cytoplasm adjacent to morulae. Common or closely related interacting partners ofE. chaffeensisTRP32, TRP47, and TRP120 demonstrate a molecular convergence on common cellular processes and molecular cross talk betweenEhrlichiaTRPs and host targets. These findings further support the role of TRPs as effectors that promote intracellular survival.

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17

Prima, Victor, Lia Gore, Aimee Caires, Theresa Boomer, Miyako Yoshinari, Imaizume Masue, Varella-Garcia Marileila, and Stephen P. Hunger. "Chimeric MEF2D and Dazap1 Fusion Proteins Are Created by a Variant t(1;19)(q23;p13.3) in Acute Lymphoblastic Leukemia (ALL)." Blood 104, no. 11 (November 16, 2004): 548. http://dx.doi.org/10.1182/blood.v104.11.548.548.

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Abstract The t(1;19)(q23;p13) is one of the most common chromosome translocations in ALL. In 90–95% of ALL cases with a t(1;19), the 19p13.3 gene E2A is fused to PBX1 located at 1q23, producing E2A-PBX1 chimeric proteins that possess transforming properties. The molecular abnormalities present in the 5–10% of ALL cases with a t(1;19) but no E2A-PBX1 fusion are unknown. TS-2 is an ALL cell line with a t(1;19)(q23;p13.3) but no E2A-PBX1 fusion. We used fluoresence in situ hybridization to localize the chromosome 19 breakpoint in TS-2 to a region approximately 400 kilobases telomeric to E2A and found that the t(1;19) in TS-2 fuses the 19p13 gene DAZAP1 (deleted in azoospermia associated protein 1) to the 1q23 gene MEF2D (myocte enhancer factor 2D). We cloned and sequenced the fusion genes and found they encode for reciprocal in-frame DAZAP1/MEF2D and MEF2D/DAZAP1 fusion transcripts, both of which are expressed in TS-2. MEF2D is a member of the MEF2 family of DNA binding proteins, which were originally characterized as muscle-specific transcription factors that regulated transcription of genes involved in myogenic differentiation. MEF2 proteins are now recognized to have more diverse functions: they are transcriptional effectors of mitogenic signaling pathways and inflammation, play critical roles in calcium-regulated signaling pathways that mediate survival of neurons and T-lympocytes, and participate in neuronal plasticity. DAZAP1 is a protein with novel RNA binding properties that is expressed most abundantly in testis and to a lesser extent in thymus. MEF2D-DAZAP1 includes the MEF2D MADS (MCM1, agamous, deficiens, and serum response factor) box and adjacent MEF2D domain that mediate sequence-specific DNA binding and protein-protein interactions, as well as one of two MEF2D transcriptional activation domains (TAD) fused to the C-terminus of DAZAP1. The DAZAP1-MEF2D chimera includes an intact first and truncated second RNA recognition motif from DAZAP1 joined to the C-terminus of MEF2D that includes its second TAD. We performed electrophoretic mobility shift assays using cognate and mutant MEF2D DNA recognition sites and found that MEF2D/DAZAP1 binds avidly and specifically to DNA in a manner indistinguishable from that of native MEF2D. We found that MEF2D/DAZAP1 activated transcription of a luciferase reporter gene under control of MEF2D recognition elements with substantially more potency than did wild type MEF2D. We also show that DAZAP1/MEF2D proteins bind RNA in a sequence specific manner analogous to that of wild type DAZAP1. MEF2D has been identified as a candidate oncogene involved in development of leukemia/lymphoma via murine retroviral insertional mutagenesis studies. Our data implicate MEF2D in human cancer and suggest that MEF2D/DAZAP1 and/or DAZAP1/MEF2D contributes to leukemogenesis by altering signaling pathways normally regulated by wild type MEF2D and DAZAP1.

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18

Morton, Simon, Huei-Ting Yang, Ntsane Moleleki, David G. Campbell, Philip Cohen, and Simon Rousseau. "Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ." Biochemical Journal 399, no. 2 (September 27, 2006): 265–73. http://dx.doi.org/10.1042/bj20060681.

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A protein in RAW 264.7 macrophages, which became phosphorylated in response to LPS (lipopolysaccharide), was identified as the RNA-binding protein called DAZAP1 [DAZ (deleted in azoospermia)-associated protein 1]. The phosphorylation of this protein was prevented by specific inhibition of MKK1 [MAPK (mitogen-activated protein kinase) kinase 1], indicating that it was phosphorylated via the classical MAPK cascade. Further experiments showed that DAZAP1 was phosphorylated stoichiometrically in vitro by ERK2 (extracellular-signal-regulated protein kinase 2) at two Thr-Pro sequences (Thr269 and Thr315), and that both sites became phosphorylated in HEK-293 (human embryonic kidney 293) cells in response to PMA or EGF (epidermal growth factor), or RAW 264.7 macrophages in response to LPS. Phosphorylation induced by each stimulus was prevented by two structurally distinct inhibitors of MKK1 (PD184352 and U0126), demonstrating that DAZAP1 is a physiological substrate for ERK1/ERK2. The mutation of Thr269 and Thr315 to aspartate or the phosphorylation of these residues caused DAZAP1 to dissociate from its binding partner DAZ. DAZ interacts with PABP [poly(A)-binding protein] and thereby stimulates the translation of mRNAs containing short poly(A) tails [Collier, Gorgoni, Loveridge, Cooke and Gray (2005) EMBO J. 24, 2656–2666]. In the present study we have shown that DAZ cannot bind simultaneously to DAZAP1 and PABP, and suggest that the phosphorylation-induced dissociation of DAZ and DAZAP1 may allow the former to stimulate translation by interacting with PABP.

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19

Warr, Cordelia. "Proving Stigmata: Antonio Daza, Saint Francis of Assisi and Juana de la Cruz." Studies in Church History 52 (June 2016): 283–97. http://dx.doi.org/10.1017/stc.2015.16.

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The Franciscan Antonio Daza, a native of Valladolid, published his Historia de las llagas de nuestro seráfico padre San Francesco in 1617. He intended to demonstrate that the stigmata of Francis of Assisi were miraculous and unique. Daza referred to Juana de la Cruz (d. 1534), a Poor Clare, whom he identified as providing evidence of the veracity of Francis's stigmata in her sermons, which had been collected by one of the nuns in her convent in a manuscript known as El Conhorte. Juana's sermons were defended as divinely inspired and thus her defence of the miracle of Francis's stigmata was regarded as based on information received directly from God. Yet Juana herself had, according to another work by Daza, the Historia, vida y milagros, éxtasis y revelaciones de la bienaventurada virgen Santa Iuana de la Cruz (first published in 1610) received painful marks on her hands and feet in 1524. This paper will consider the tensions evidenced in Daza's work and his tactics in attempting to demonstrate the unique nature of the stigmata of Francis of Assisi whilst at the same time apparently acknowledging a similar miracle experienced by Juana de la Cruz.

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20

Yang, Chi-Kai, and Pauline Yen. "Differential Translation of Dazap1 Transcripts during Spermatogenesis." PLoS ONE 8, no. 4 (April 26, 2013): e60873. http://dx.doi.org/10.1371/journal.pone.0060873.

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21

Prima, V., and S. P. Hunger. "Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia." Leukemia 21, no. 12 (September 27, 2007): 2470–75. http://dx.doi.org/10.1038/sj.leu.2404962.

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22

Goina, Elisa, Natasa Skoko, and Franco Pagani. "Binding of DAZAP1 and hnRNPA1/A2 to an Exonic Splicing Silencer in a Natural BRCA1 Exon 18 Mutant." Molecular and Cellular Biology 28, no. 11 (April 7, 2008): 3850–60. http://dx.doi.org/10.1128/mcb.02253-07.

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ABSTRACT A disease-causing G-to-T transversion at position +6 of BRCA1 exon 18 induces exclusion of the exon from the mRNA and, as has been suggested by in silico analysis, disrupts an ASF/SF2-dependent splicing enhancer. We show here using a pulldown assay with an internal standard that wild-type (WT) and mutant T6 sequences displayed similar ASF/SF2 binding efficiencies, which were significantly lower than that of a typical exonic splicing enhancer derived from the extra domain A exon of fibronectin. Overexpression or small interfering RNA (siRNA)-mediated depletion of ASF/SF2 did not affect the splicing of a WT BRCA1 minigene but resulted in an increase and decrease of T6 exon 18 inclusion, respectively. Furthermore, extensive mutation analysis using hybrid minigenes indicated that the T6 mutant creates a sequence with a prevalently inhibitory function. Indeed, RNA-protein interaction and siRNA experiments showed that the skipping of T6 BRCA1 exon 18 is due to the creation of a splicing factor-dependent silencer. This sequence specifically binds to the known repressor protein hnRNPA1/A2 and to DAZAP1, the involvement of which in splicing inhibition we have demonstrated. Our results indicate that the binding of the splicing factors hnRNPA1/A2 and DAZAP1 is the primary determinant of T6 BRCA1 exon 18 exclusion.

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Burke, Nancy J., Kristine Phung, Filmer Yu, Ching Wong, Khanh Le, Isabel Nguyen, Long Nguyen, Alice Guan, Tung T. Nguyen, and Janice Y. Tsoh. "Unpacking the ‘black box’ of lay health worker processes in a US-based intervention." Health Promotion International 35, no. 1 (January 31, 2019): 173. http://dx.doi.org/10.1093/heapro/daz002.

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Moysés, Samuel J., and Renata C. Soares. "Planetary health in the Anthropocene." Health Promotion International 34, Supplement_1 (February 11, 2019): i28—i36. http://dx.doi.org/10.1093/heapro/daz012.

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Kickbusch, Ilona. "Health promotion 4.0." Health Promotion International 34, no. 2 (April 1, 2019): 179–81. http://dx.doi.org/10.1093/heapro/daz022.

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Riley, Emily, Peter Sainsbury, Phil McManus, Ruth Colagiuri, Francesca Viliani, Angus Dawson, Elizabeth Duncan, Yolande Stone, Tracy Pham, and Patrick Harris. "Including health impacts in environmental impact assessments for three Australian coal-mining projects: a documentary analysis." Health Promotion International 35, no. 3 (May 5, 2019): 449–57. http://dx.doi.org/10.1093/heapro/daz032.

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Abstract Notwithstanding the historical benefits of coal in aiding human and economic development, the negative health and environmental impacts of coal extraction and processing are of increasing concern. Environmental impact assessments (EIAs) are a regulated policy mechanism that can be used to predict and consider the health impacts of mining projects to determine if consent is given. The ways in which health is considered within EIA is unclear. This research investigated ‘How and to what extent are health, well-being and equity issues considered in Environmental Impact Assessments (EIAs) of major coal mining projects in New South Wales, Australia’. To this end we developed and applied a comprehensive coding framework designed to interrogate the publicly available environmental impact statements (EISs) of three mines in New South Wales (NSW), Australia, for their inclusion of health, well-being and equity issues. Analysis of the three EISs demonstrates that: the possible impacts of each mine on health and well-being were narrowly and inadequately considered; when health and well-being were considered there was a failure to assess the possible impacts specific to the particular mine and the communities potentially affected; the cumulative impacts on human health of multiple mines in the same geographical area were almost completely ignored; the discussions of intragenerational and intergenerational equity did not demonstrate a sound understanding of equity and, it is essential that governments’ requirements for the EIA include detailed analysis of the health, well-being, equity and cumulative impacts specific to the proposed mine and relevant communities.

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Glass, Catherine T. R., and Audrey R. Giles. "Community-based risk messaging in Inuvik, Northwest Territories, Canada." Health Promotion International 35, no. 3 (June 7, 2019): 555–61. http://dx.doi.org/10.1093/heapro/daz042.

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Abstract Unintentional injuries are one of the leading causes of death worldwide, yet they are predictable and avoidable events. Community-based approaches to injury prevention are those where researchers and/or injury prevention specialists work alongside the target population to identify injury prevention issues and then co-create strategies that are relevant to the population. Community-based strategies differ from other approaches as they strive to conduct research with, rather than on marginalized groups. A community-based approach to social marketing, injury prevention and risk messaging was applied in Inuvik, Northwest Territories, Canada, to examine and address men’s boating safety behaviours. Community participants identified the need for northern-based safety resources and a community-wide education campaign. As demonstrated through this example, community-based strategies should be considered for injury prevention, as the involvement of local community members may lead to more effective risk messaging that reflects the needs, culture, and experiences of the target group, while promoting healthy behaviours.

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Gulis, Gabriel. "Health impact assessment and the sustainable development goals." Health Promotion International 34, no. 3 (June 1, 2019): 373–75. http://dx.doi.org/10.1093/heapro/daz052.

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Huse, Oliver, Christina Zorbas, Alethea Jerebine, Ari Kurzeme, Miranda Blake, Megan Ferguson, Claire Palermo, et al. "Recreation centre managers’ perceptions of pricing interventions to promote healthy eating." Health Promotion International 35, no. 4 (July 3, 2019): 682–91. http://dx.doi.org/10.1093/heapro/daz062.

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Abstract Retailers have the capacity to improve the food and beverage environment by making healthier options more affordable and attractive for their consumers. The perspectives of retailers on feasible and acceptable pricing strategies are not known. The aim of this study was to understand retailers’ perceptions of factors that are relevant to feasible and acceptable health-promoting food and beverage pricing interventions. A convenience sample of 11 aquatic and recreation centre managers in Victoria, Australia was recruited to participate in semi-structured interviews. We took a pragmatic approach with the aim of understanding retailers’ perceptions of factors that affect the feasibility and acceptability of pricing interventions within their facilities. Thematic analysis was used to synthesize and interpret retailers’ perceptions of pricing interventions. Key themes identified were: structural and organizational characteristics (the internal and external characteristics of aquatic and recreation centres), characteristics of feasible pricing changes (type, magnitude and products targeted by pricing strategies) and business outcomes (profits and customer feedback). Results suggest that pricing interventions to promote healthy food and beverage choices can be feasible and acceptable to retailers, though contextual considerations are likely to be important. Future studies should use these findings to design interventions most likely to be acceptable to retailers, work with retailers to implement health-promoting food and beverage pricing interventions, evaluate the impact on business outcomes including customer perspectives and profitability, and test transferability to other retail settings.

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Dooris, Mark, Sue Powell, and Alan Farrier. "Conceptualizing the ‘whole university’ approach: an international qualitative study." Health Promotion International 35, no. 4 (July 15, 2019): 730–40. http://dx.doi.org/10.1093/heapro/daz072.

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Abstract Focusing on the conceptualization of a whole university approach, this paper reports on an international qualitative study that explored vice-chancellors’ and network members’ understanding of and commitment to Health Promoting Universities, examined perspectives on leadership and investigated the Okanagan Charter’s potential to catalyse whole university leadership and change. A multi-method qualitative approach was used: semi-structured interviews and focus groups were conducted face-to-face with vice-chancellors (n = 12) and Health Promoting University co-ordinators who were members of the UK Healthy Universities Network (n = 8); telephone interviews were conducted with a mix of UK and non-UK Health Promoting University co-ordinators (n = 5) and two online questionnaires were distributed to non-UK network co-ordinators (n = 6) and non-UK Health Promoting University co-ordinators (n = 10). Through thematic analysis, a number of key themes emerged that build a new conceptualization of the whole university approach (see Figure 1): building a broad understanding and framing of health; developing a supportive ethos and culture; embedding health into the university and joining up areas of work; focusing on the whole population and facing challenges and seizing opportunities. The study elicited rich and wide-ranging views from multiple stakeholders from universities and networks across four continents, confirming Health Promoting Universities as a truly global movement. Looking ahead, there are clear opportunities and challenges. First, the media narrative of a student mental health ‘crisis’ has focused universities’ attention on ‘health’, but from a single issue ‘illness’ perspective. This risks detracting from the whole system Health Promoting Universities approach. Second, even with the Okanagan Charter inspiring individuals and universities, there are still major challenges in translating the rhetoric of whole system approaches into meaningful action within large, complex and culturally diverse organizations.

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Lilly, Kara, Jonathan Hallett, Suzanne Robinson, and Linda A. Selvey. "Insights into local health and wellbeing policy process in Australia." Health Promotion International 35, no. 5 (August 29, 2019): 925–34. http://dx.doi.org/10.1093/heapro/daz082.

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Abstract To investigate factors that enable or challenge the initiation and actioning of health and wellbeing policy in Australian local governments using political science frameworks. An online survey was distributed to staff and elected members of Australian local governments. The survey sought responses to a range of variables as informed by political science frameworks. Data were analysed using descriptive statistics and results were compared between local governments of different geographical sizes and locations using Kruskal–Wallis non-parametric testing. There were 1825 survey responses, including 243 CEOs, representing 45% of Australian local governments. Enablers for local government policy initiation and action included the high priority given to health and wellbeing (44%), local leadership (56%) and an organizational (70%) and personal obligation (68%) to the community to act. Less true is a favourable legislative environment (33%), leadership from higher levels of government (29%) and sufficient financial capacity (22%). Cities are better positioned to initiate and action health policy, regardless of the broader legislative environment. Health and wellbeing is a high priority for Australian local governments, despite lack of funding and limited lobbying and support from other sectors and higher levels of government. The insights from political science frameworks assist to understand the policy process, including the interrelatedness of enablers and challenges to initiating and actioning health and wellbeing policy. Further understanding the policy drivers would support practitioners and researchers advocating to influence local health and wellbeing policy.

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Matheson, Anna, Mat Walton, Rebecca Gray, Nan Wehipeihana, and Jonathon Wistow. "Strengthening prevention in communities through systems change: lessons from the evaluation of Healthy Families NZ." Health Promotion International 35, no. 5 (September 8, 2019): 947–57. http://dx.doi.org/10.1093/heapro/daz092.

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Abstract This article presents the findings from the first 3 years of the evaluation of Healthy Families NZ, a systems-change intervention to prevent chronic diseases in 10 communities. The initiative, which builds on existing prevention activities, aims to strengthen the health prevention system through evidence-driven action to enable people to make good food choices, be physically active, smoke-free and free from alcohol-related harm. Key investment areas are a dedicated systems thinking and acting health promotion workforce, and activating leaders who can influence transformational change. The evaluation to date has found the initiative is being implemented with integrity. Evidence indicates a shift towards greater action on prevention, and the prevention system being strengthened. Māori ownership has been enabled, and prioritizing equity has led teams to utilize methods that amplify diverse local perspectives. There is progress on developing a flexible workforce through adaptive learning, flexible resources, professional development and a responsive National team. There is also progress in activating local leadership and empowering local teams. The initiative design has explicitly taken into account the context of complexity within which it is being implemented. It has evolved to focus on action that can accelerate sharing information and practices within communities, and between policy and decision-makers. Healthy Families NZ and its evaluation have been refunded to 2022. This provides an important opportunity to gather further insight into effective ways to strengthen the community agency and trust needed to promote and deliver evidence-based action on prevention.

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Henderson, Fiona, Artur Steiner, Micaela Mazzei, and Catherine Docherty. "Social enterprises’ impact on older people’s health and wellbeing: exploring Scottish experiences." Health Promotion International 35, no. 5 (October 9, 2019): 1074–84. http://dx.doi.org/10.1093/heapro/daz102.

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Abstract The global aging demographic is putting pressure on state-delivered health and social care services. As the austerity agenda in the UK cuts state-funded service provision for older people despite increasing demand, social enterprise has become a politically and economically attractive model for the sustainable delivery of some public services. Yet little is known about the impact of social enterprise on the health and wellbeing of older people. In this paper we address this gap in understanding and consider social enterprise activities as complex public health-promoting interventions. Our study aimed to understand what impact social enterprise activities had on the health and wellbeing of participants aged over 50, and also how that impact was created. To achieve this, we conducted qualitative semi-structured interviews with a sample (n = 43) of staff, volunteers, clients and carers aged over 50 who were involved in activities delivered by three social enterprises. Using a thematic analysis to explore manifest and latent themes, two antecedents of subjective younger age emerged explaining how benefit was created, namely downward social comparison and identity. The social enterprise activities we studied benefited participants' health and wellbeing, impacting positively on participants' sense of purpose, social support, connectedness and inclusion. These health and wellbeing benefits can be considered as outcomes of complex public health interventions for older people, and we relate these outcomes to beneficial conditions within the intermediary social determinants of health. We conclude by discussing the future impact of social enterprise activities and current UK policy on the structural determinants of health.

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Broetje, Sylvia, Georg F. Bauer, and Gregor J. Jenny. "The relationship between resourceful working conditions, work-related and general sense of coherence." Health Promotion International 35, no. 5 (November 11, 2019): 1168–79. http://dx.doi.org/10.1093/heapro/daz112.

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Abstract Sense of coherence (SoC) has been identified as an important health resource and is associated with various health-related outcomes, especially perceived health and mental health. SoC has also been found to be relevant in the work context. Our study examined whether job resources, such as autonomy or social support, can contribute to the development of SoC. We also examined the role of the setting-specific work-related sense of coherence (Work-SoC) as well as reciprocal relationships between the three variables. Participants (941) from Germany, Switzerland and Austria completed our questionnaires at three waves of data collection. Structural equation modeling was used to identify the best fitting model and interpret the relationships between variables. Our first hypothesis that job resources predict Work-SoC and that Work-SoC predicts SoC was confirmed. We also found support for our second hypothesis that SoC predicts Work-SoC and that Work-SoC predicts job resources. The indirect effects through Work-SoC were only marginally significant in both directions. Our findings illustrate complex and multidirectional relationships between the variables. Job resources seem to contribute to the strengthening of Work-SoC, which seems to set in motion a gain cycle of improved job resources, which again contribute to a higher Work-SoC. Over time, this might contribute to strengthening general SoC. However, our findings showed that SoC was highly stable over the observed 3-month interval, limiting the effect any other variable could exert on it. Future research should further examine the mechanisms and timeframes over which a setting-specific SoC contributes to the development of overall SoC.

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Rafeld, Jessie, Kristen Moeller-Saxone, Sue Cotton, Simon Rice, Katherine Monson, Carol Harvey, and Helen Herrman. "‘Getting our voices out there’: acceptability of a mental health participation programme for young people with out of home care experience in Australia." Health Promotion International 35, no. 6 (December 10, 2019): 1614. http://dx.doi.org/10.1093/heapro/daz122.

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Love, Penelope, Alison Booth, Claire Margerison, Caryl Nowson, and Carley Grimes. "Food and nutrition education opportunities within Australian primary schools." Health Promotion International 35, no. 6 (January 17, 2020): 1291–301. http://dx.doi.org/10.1093/heapro/daz132.

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Abstract Schools are regarded as a key setting for obesity prevention, providing an opportunity to reach a large number of children, frequently and over a prolonged period, through formal and informal opportunities to learn about health behaviours. However, the low value placed on health versus academic achievement is a barrier to effective implementation of food and nutrition (F&N) education. This study used a qualitative exploratory approach to explore the views of teachers and key health and education sector stakeholders regarding opportunities for F&N education within the Australian primary school setting. To the best of our knowledge, this is the first study to explore this topic from the perspectives of state-level coordination and development through to local-level implementation and support within the Australian primary school context. Only 2.6% of the Victorian Curriculum related to F&N education, taught through two (of seven) learning outcomes: Health and Physical Education, and Technologies. While stakeholders considered child health a priority, and schools an ideal setting for F&N education, barriers included a lack of strategic policy alignment, limited leadership and coordination, a ‘crowded curriculum’ and poor availability of shelf-ready resources with explicit curriculum links. A cross-curriculum approach was considered essential for F&N education to become embedded as a core component of the curriculum.

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Chen, Hsiang-Ying, Yueh-Hsiang Yu, and Pauline H. Yen. "DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts." Nucleic Acids Research 41, no. 21 (August 21, 2013): 9858–69. http://dx.doi.org/10.1093/nar/gkt746.

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38

Prima, V., L. Gore, A. Caires, T. Boomer, M. Yoshinari, M. Imaizumi, M. Varella-Garcia, and S. P. Hunger. "Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia." Leukemia 19, no. 5 (March 3, 2005): 806–13. http://dx.doi.org/10.1038/sj.leu.2403684.

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39

Orbaugh, Sharalyn, and Alan Wolfe. "Suicide and Dazai." Journal of the Association of Teachers of Japanese 24, no. 2 (November 1990): 185. http://dx.doi.org/10.2307/488953.

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Lin, Yi-Tzu, Wan-Ching Wen, and Pauline H. Yen. "Transcription-dependent nuclear localization of DAZAP1 requires an N-terminal signal." Biochemical and Biophysical Research Communications 428, no. 3 (November 2012): 422–26. http://dx.doi.org/10.1016/j.bbrc.2012.10.076.

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41

GANTAR, Lija. "Ancient Greek Legend in Modern Japanese Literature: “Run, Melos!” by Dazai Osamu." Acta Linguistica Asiatica 7, no. 2 (December 29, 2017): 51–68. http://dx.doi.org/10.4312/ala.7.2.51-68.

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Dazai Osamu (1909-1948), a modern Japanese writer, wrote “Run, Melos!” in 1940. The short story is a rework of an Ancient Greek legend of Damon and Pythias from the 4th century B.C., which was introduced to Dazai through Schiller’s version of the legend, “The Hostage”. The legend, based on a true event, represents the perfect friendship and was reworked a number of times by different antique writers. After having been forgotten for a while, it reappeared in the Middle Ages as a fictional story and has gotten many new adaptations from then on. One of them was Schiller’s ballad in 1798, which – alongside an anecdote from Dazai’s own life – represented the basis for Dazai’s story. Even though “Run, Melos!” is not an autobiographical work, Dazai managed to pass his own feelings onto the characters, add some biblical elements, and included a never-before-employed dark twist in the story, thus making his version more realistic than the preceding ones. Despite the distance in time and place between him and the legend, with “Run, Melos!”, Dazai managed to retell a Western literature story, making it a part of the Japanese literature as well, adding motifs and themes influenced by his own life, time, and place.

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WENG, Bo, Mao-liang RAN, Rong CAO, Fu-zhi PENG, Hui LUO, Hu GAO, Xiang-wei TANG, Anqi YANG, and Bin CHEN. "miR-10b promotes porcine immature Sertoli cell proliferation by targeting the DAZAP1 gene." Journal of Integrative Agriculture 18, no. 8 (August 2019): 1924–35. http://dx.doi.org/10.1016/s2095-3119(19)62564-5.

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43

Hsu, L. C. L., H. Y. Chen, Y. W. Lin, W. C. Chu, M. J. Lin, Y. T. Yan, and P. H. Yen. "DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice." RNA 14, no. 9 (July 24, 2008): 1814–22. http://dx.doi.org/10.1261/rna.1152808.

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Lin, Y. T. "A novel nucleocytoplasmic shuttling sequence of DAZAP1, a testis-abundant RNA-binding protein." RNA 12, no. 8 (June 29, 2006): 1486–93. http://dx.doi.org/10.1261/rna.42206.

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Pan, Hsien-An, Yue-Shan Lin, Ko-Hung Lee, Jin-Ru Huang, Ying-Hui Lin, and Pao-Lin Kuo. "Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries." Fertility and Sterility 84 (October 2005): 1089–94. http://dx.doi.org/10.1016/j.fertnstert.2005.03.075.

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Smith, R. W. P., R. C. Anderson, J. W. S. Smith, M. Brook, W. A. Richardson, and N. K. Gray. "DAZAP1, an RNA-binding protein required for development and spermatogenesis, can regulate mRNA translation." RNA 17, no. 7 (May 16, 2011): 1282–95. http://dx.doi.org/10.1261/rna.2717711.

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Rogers, Lawrence, Dazai Osamu, and James O'Brien. "Dazai Osamu: Selected Stories and Sketches." Journal of the Association of Teachers of Japanese 21, no. 1 (April 1987): 113. http://dx.doi.org/10.2307/488901.

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Kim, Na-kyung. "The attitude of the middle dazai." Japanese Language and Literature Association of Daehan ll, no. 46 (May 2010): 129–40. http://dx.doi.org/10.18631/jalali.2010..46.007.

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中嶋駒子. "A study of Dazai Osamu's "Chikyuzu"." Japanese Language and Literature Association of Daehan ll, no. 73 (February 2017): 125–44. http://dx.doi.org/10.18631/jalali.2017..73.007.

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전봉이. "The Study of Dazai osamu “Sinrou”." Journal of Japanese Studies ll, no. 33 (September 2007): 139–54. http://dx.doi.org/10.15733/jast.2007..33.139.

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