Relevant bibliographies by topics / DCAF12L2

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  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'DCAF12L2'

Author: Grafiati
Published: 11 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "DCAF12L2"

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Zhang, Xiu-Xia, Xin Yu, Li Zhu, and Jun-Hua Luo. "Establishment of a 6-signature risk model associated with cellular senescence for predicting the prognosis of breast cancer." Medicine 102, no. 46 (2023): e35923. http://dx.doi.org/10.1097/md.0000000000035923.

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This study focused on screening novel markers associated with cellular senescence for predicting the prognosis of breast cancer. The RNA-seq expression profile of BRCA and clinical data were obtained from TCGA. The pam algorithm was used to cluster patients based on senescence-related genes. The weighted gene co-expression network analysis was used to identify co-expressed genes, and LASSO-Cox analysis was performed to build a risk prognosis model. The performance of the model was also evaluated. We additionally explored the role of senescence in cancer development and possible regulatory mech
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Patrón, Lilian A., Kei Nagatomo, David Tyler Eves, et al. "Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity." Journal of Cell Biology 218, no. 3 (2019): 993–1010. http://dx.doi.org/10.1083/jcb.201805099.

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We genetically characterized the synaptic role of the Drosophila homologue of human DCAF12, a putative cofactor of Cullin4 (Cul4) ubiquitin ligase complexes. Deletion of Drosophila DCAF12 impairs larval locomotion and arrests development. At larval neuromuscular junctions (NMJs), DCAF12 is expressed presynaptically in synaptic boutons, axons, and nuclei of motor neurons. Postsynaptically, DCAF12 is expressed in muscle nuclei and facilitates Cul4-dependent ubiquitination. Genetic experiments identified several mechanistically independent functions of DCAF12 at larval NMJs. First, presynaptic DC
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Lidak, Tomas, Nikol Baloghova, Vladimir Korinek, et al. "CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation." International Journal of Molecular Sciences 22, no. 10 (2021): 5394. http://dx.doi.org/10.3390/ijms22105394.

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Multisubunit cullin-RING ubiquitin ligase 4 (CRL4)-DCAF12 recognizes the C-terminal degron containing acidic amino acid residues. However, its physiological roles and substrates are largely unknown. Purification of CRL4-DCAF12 complexes revealed a wide range of potential substrates, including MOV10, an “ancient” RNA-induced silencing complex (RISC) complex RNA helicase. We show that DCAF12 controls the MOV10 protein level via its C-terminal motif in a proteasome- and CRL-dependent manner. Next, we generated Dcaf12 knockout mice and demonstrated that the DCAF12-mediated degradation of MOV10 is
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Hwangbo, Dae-Sung, Benoit Biteau, Sneha Rath, Jihyun Kim, and Heinrich Jasper. "Control of apoptosis by Drosophila DCAF12." Developmental Biology 413, no. 1 (2016): 50–59. http://dx.doi.org/10.1016/j.ydbio.2016.03.003.

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Nong, Weidong, Fang Huang, Fengping Mao, Dayuan Lao, Zhuowei Gong, and Wen Huang. "DCAF12 and HSPA1A May Serve as Potential Diagnostic Biomarkers for Myasthenia Gravis." BioMed Research International 2022 (May 24, 2022): 1–15. http://dx.doi.org/10.1155/2022/8587273.

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Background. Myasthenia gravis (MG) is an autoimmune disease that severely affects the life quality of patients. This study explores the differences in immune cell types between MG and healthy control and the role of immune-related genes in the diagnosis of MG. Methods. The GSE85452 dataset was downloaded from the Gene Expression Omnibus (GEO) database and analyzed using the limma package to determine differentially expressed genes (DEGs) between patients with MG and the control group. Differentially expressed immune cells were analyzed using single-sample gene set enrichment analysis (GSEA), w
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Akalin, Enver, Matthew R. Weir, Suphamai Bunnapradist, et al. "Clinical Validation of an Immune Quiescence Gene Expression Signature in Kidney Transplantation." Kidney360 2, no. 12 (2021): 1998–2009. http://dx.doi.org/10.34067/kid.0005062021.

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BackgroundDespite advances in immune suppression, kidney allograft rejection and other injuries remain a significant clinical concern, particularly with regards to long-term allograft survival. Evaluation of immune activity can provide information about rejection status and help guide interventions to extend allograft life. Here, we describe the validation of a blood gene expression classifier developed to differentiate immune quiescence from both T cell–mediated rejection (TCMR) and antibody-mediated rejection (ABMR).MethodsA five-gene classifier (DCAF12, MARCH8, FLT3, IL1R2, and PDCD1) was d
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Gordeuk, Victor R., Xu Zhang, Wei Zhang, et al. "Iron Deficiency Modifies Gene Expression Variation Induced by Augmented Hypoxia Sensing." Blood 120, no. 21 (2012): 1765. http://dx.doi.org/10.1182/blood.v120.21.1765.1765.

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Abstract Abstract 1765 Hypoxia may cause pulmonary and brain edema, pulmonary hypertension, aberrant metabolism and early mortality. To better understand pathological processes associated with hypoxia, we examined gene expression in Chuvash polycythemia blood mononuclear cells. Chuvash polycythemia is a congenital disorder of up-regulated hypoxic response at normoxia wherein VHLR200W homozygosity leads to elevated hypoxia inducible factor (HIF)-1 and HIF-2 levels, thromboses, pulmonary hypertension, lower systemic blood pressure (SBP) and increased mortality. VHLR200W homozygotes are often tre
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Gordeuk, Victor R., Xu Zhang, Wei Zhang, et al. "The Hypoxic Response and Altered Gene Expression in Patients with Sickle Cell Disease." Blood 120, no. 21 (2012): 3245. http://dx.doi.org/10.1182/blood.v120.21.3245.3245.

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Abstract Abstract 3245 Sickle cell disease (SCD) and Chuvash polycythemia (CP) are both monogenic hematologic disorders, the first resulting in hemolytic anemia and the second in polycythemia related to an upregulated hypoxic response at normoxia. Specifically, homozygosity for the VHLR200W mutation leads to increased levels of the transcription factors hypoxia inducible factor (HIF)-1 and HIF-2 at normoxia and altered transcription of many genes. Much attention in the pathophysiology of SCD has focused on the adverse effects of chronic inflammation, enhanced cellular adhesion pathways and hem
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Righetto, Germanna Lima, Yanting Yin, David M. Duda, et al. "Probing CRL4DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons." PNAS Nexus, April 10, 2024. http://dx.doi.org/10.1093/pnasnexus/pgae153.

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Abstract DDB1- And CUL4- Associated Factor 12 (DCAF12) serves as the substrate recognition component within the Cullin4-RING E3 Ligase (CRL4) complex, capable of identifying C-terminal double-glutamic acid degrons to promote the degradation of specific substrates through the ubiquitin proteasome system. MAGEA3 and CCT5 proteins have been identified as cellular targets of DCAF12. To further characterize the interactions between DCAF12 and both MAGEA3 and CCT5, we developed a suite of biophysical and proximity-based cellular NanoBRET assays showing that the C-terminal degron peptides of both MAG
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Wu, Ruishan, Cailin Wu, Bingming Zhu, Jin Li, and Wenzhong Zhao. "Screening and validation of potential markers associated with uterine corpus endometrial carcinoma and polycystic ovary syndrome based on bioinformatics methods." Frontiers in Molecular Biosciences 10 (June 9, 2023). http://dx.doi.org/10.3389/fmolb.2023.1192313.

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Background: Endometrial cancer (UCEC) is a commonly occurring tumor in females, and polycystic ovary syndrome (PCOS) is closely related to UCEC, but the molecular mechanisms remain unclear. This article aims to explore potential molecular mechanisms in UCEC and PCOS, as well as identify prognostic genes for UCEC.Methods: Bioinformatics methods were employed to screen for DEGs in UCEC and PCOS. The shared DEGs were analyzed by constructing a protein-protein interaction (PPI) network using the String database and Cytoscape software. The enrichment analysis was performed using Metascape. The shar
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Dissertations / Theses on the topic "DCAF12L2"

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Patrón, Lilian Adilene, and Lilian Adilene Patrón. "DCAF12 Is Required For Synaptic Function and Plasticity at the Drosophila Neuromuscular Junction." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/624292.

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We employed imaging, electrophysiological, and molecular techniques with the genetically tractable model organism Drosophila melanogaster to unravel fundamental biological and genetic underpinnings regulating synaptic function and plasticity. Using a forward genetic screen, we identified mutations in the Drosophila ortholog of a human WD40 repeat-containing protein termed DDB1 and CUL4 associated factor 12 (DCAF12). We show that DCAF12 likely serves as an adaptor protein for the DDB1-Cul4 E3 ubiquitin ligase complex by recruiting specific target proteins for ubiquitination. DCAF12 is expre
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Olaleye, Onireti Jacob. "Novel Roles of Cullin-RING Ligases in Cell Signalling and Implications in Health and Disease." Doctoral thesis, 2022. http://hdl.handle.net/11562/1070147.

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Cullin-RING ligases (CRLs) play fundamental functions in key physiological and pathological processes. To identify novel roles of CRLs in cell signalling and their implication in health and diseases, we performed two separate studies: In study 1, we analysed genomic databases to identify CRLs that are hypermutated in cancer. We found that the CRL substrate receptors FBXO24 and DCAF12L2 are hypermutated at critical domains that are necessary for the proper structure/function of the CRL1FBXO24 and CRL4DCAF12L2 complexes, respectively. We showed that the FBXO24(T65P) mutation within the F-box dom
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Book chapters on the topic "DCAF12L2"

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"Malawi." In Energy Balances and Electricity Profiles 2005. UN, 2008. http://dx.doi.org/10.18356/dcaf121b-en-fr.

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