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Journal articles on the topic 'DCAF12L2'

Author: Grafiati
Published: 11 March 2023
Last updated: 31 July 2025

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1

Zhang, Xiu-Xia, Xin Yu, Li Zhu, and Jun-Hua Luo. "Establishment of a 6-signature risk model associated with cellular senescence for predicting the prognosis of breast cancer." Medicine 102, no. 46 (2023): e35923. http://dx.doi.org/10.1097/md.0000000000035923.

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This study focused on screening novel markers associated with cellular senescence for predicting the prognosis of breast cancer. The RNA-seq expression profile of BRCA and clinical data were obtained from TCGA. The pam algorithm was used to cluster patients based on senescence-related genes. The weighted gene co-expression network analysis was used to identify co-expressed genes, and LASSO-Cox analysis was performed to build a risk prognosis model. The performance of the model was also evaluated. We additionally explored the role of senescence in cancer development and possible regulatory mech
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2

Patrón, Lilian A., Kei Nagatomo, David Tyler Eves, et al. "Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity." Journal of Cell Biology 218, no. 3 (2019): 993–1010. http://dx.doi.org/10.1083/jcb.201805099.

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We genetically characterized the synaptic role of the Drosophila homologue of human DCAF12, a putative cofactor of Cullin4 (Cul4) ubiquitin ligase complexes. Deletion of Drosophila DCAF12 impairs larval locomotion and arrests development. At larval neuromuscular junctions (NMJs), DCAF12 is expressed presynaptically in synaptic boutons, axons, and nuclei of motor neurons. Postsynaptically, DCAF12 is expressed in muscle nuclei and facilitates Cul4-dependent ubiquitination. Genetic experiments identified several mechanistically independent functions of DCAF12 at larval NMJs. First, presynaptic DC
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3

Lidak, Tomas, Nikol Baloghova, Vladimir Korinek, et al. "CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation." International Journal of Molecular Sciences 22, no. 10 (2021): 5394. http://dx.doi.org/10.3390/ijms22105394.

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Multisubunit cullin-RING ubiquitin ligase 4 (CRL4)-DCAF12 recognizes the C-terminal degron containing acidic amino acid residues. However, its physiological roles and substrates are largely unknown. Purification of CRL4-DCAF12 complexes revealed a wide range of potential substrates, including MOV10, an “ancient” RNA-induced silencing complex (RISC) complex RNA helicase. We show that DCAF12 controls the MOV10 protein level via its C-terminal motif in a proteasome- and CRL-dependent manner. Next, we generated Dcaf12 knockout mice and demonstrated that the DCAF12-mediated degradation of MOV10 is
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4

Hwangbo, Dae-Sung, Benoit Biteau, Sneha Rath, Jihyun Kim, and Heinrich Jasper. "Control of apoptosis by Drosophila DCAF12." Developmental Biology 413, no. 1 (2016): 50–59. http://dx.doi.org/10.1016/j.ydbio.2016.03.003.

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5

Nong, Weidong, Fang Huang, Fengping Mao, Dayuan Lao, Zhuowei Gong, and Wen Huang. "DCAF12 and HSPA1A May Serve as Potential Diagnostic Biomarkers for Myasthenia Gravis." BioMed Research International 2022 (May 24, 2022): 1–15. http://dx.doi.org/10.1155/2022/8587273.

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Background. Myasthenia gravis (MG) is an autoimmune disease that severely affects the life quality of patients. This study explores the differences in immune cell types between MG and healthy control and the role of immune-related genes in the diagnosis of MG. Methods. The GSE85452 dataset was downloaded from the Gene Expression Omnibus (GEO) database and analyzed using the limma package to determine differentially expressed genes (DEGs) between patients with MG and the control group. Differentially expressed immune cells were analyzed using single-sample gene set enrichment analysis (GSEA), w
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6

Akalin, Enver, Matthew R. Weir, Suphamai Bunnapradist, et al. "Clinical Validation of an Immune Quiescence Gene Expression Signature in Kidney Transplantation." Kidney360 2, no. 12 (2021): 1998–2009. http://dx.doi.org/10.34067/kid.0005062021.

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BackgroundDespite advances in immune suppression, kidney allograft rejection and other injuries remain a significant clinical concern, particularly with regards to long-term allograft survival. Evaluation of immune activity can provide information about rejection status and help guide interventions to extend allograft life. Here, we describe the validation of a blood gene expression classifier developed to differentiate immune quiescence from both T cell–mediated rejection (TCMR) and antibody-mediated rejection (ABMR).MethodsA five-gene classifier (DCAF12, MARCH8, FLT3, IL1R2, and PDCD1) was d
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7

Gordeuk, Victor R., Xu Zhang, Wei Zhang, et al. "Iron Deficiency Modifies Gene Expression Variation Induced by Augmented Hypoxia Sensing." Blood 120, no. 21 (2012): 1765. http://dx.doi.org/10.1182/blood.v120.21.1765.1765.

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Abstract Abstract 1765 Hypoxia may cause pulmonary and brain edema, pulmonary hypertension, aberrant metabolism and early mortality. To better understand pathological processes associated with hypoxia, we examined gene expression in Chuvash polycythemia blood mononuclear cells. Chuvash polycythemia is a congenital disorder of up-regulated hypoxic response at normoxia wherein VHLR200W homozygosity leads to elevated hypoxia inducible factor (HIF)-1 and HIF-2 levels, thromboses, pulmonary hypertension, lower systemic blood pressure (SBP) and increased mortality. VHLR200W homozygotes are often tre
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8

Gordeuk, Victor R., Xu Zhang, Wei Zhang, et al. "The Hypoxic Response and Altered Gene Expression in Patients with Sickle Cell Disease." Blood 120, no. 21 (2012): 3245. http://dx.doi.org/10.1182/blood.v120.21.3245.3245.

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Abstract Abstract 3245 Sickle cell disease (SCD) and Chuvash polycythemia (CP) are both monogenic hematologic disorders, the first resulting in hemolytic anemia and the second in polycythemia related to an upregulated hypoxic response at normoxia. Specifically, homozygosity for the VHLR200W mutation leads to increased levels of the transcription factors hypoxia inducible factor (HIF)-1 and HIF-2 at normoxia and altered transcription of many genes. Much attention in the pathophysiology of SCD has focused on the adverse effects of chronic inflammation, enhanced cellular adhesion pathways and hem
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9

Righetto, Germanna Lima, Yanting Yin, David M. Duda, et al. "Probing CRL4DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons." PNAS Nexus, April 10, 2024. http://dx.doi.org/10.1093/pnasnexus/pgae153.

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Abstract DDB1- And CUL4- Associated Factor 12 (DCAF12) serves as the substrate recognition component within the Cullin4-RING E3 Ligase (CRL4) complex, capable of identifying C-terminal double-glutamic acid degrons to promote the degradation of specific substrates through the ubiquitin proteasome system. MAGEA3 and CCT5 proteins have been identified as cellular targets of DCAF12. To further characterize the interactions between DCAF12 and both MAGEA3 and CCT5, we developed a suite of biophysical and proximity-based cellular NanoBRET assays showing that the C-terminal degron peptides of both MAG
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10

Wu, Ruishan, Cailin Wu, Bingming Zhu, Jin Li, and Wenzhong Zhao. "Screening and validation of potential markers associated with uterine corpus endometrial carcinoma and polycystic ovary syndrome based on bioinformatics methods." Frontiers in Molecular Biosciences 10 (June 9, 2023). http://dx.doi.org/10.3389/fmolb.2023.1192313.

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Background: Endometrial cancer (UCEC) is a commonly occurring tumor in females, and polycystic ovary syndrome (PCOS) is closely related to UCEC, but the molecular mechanisms remain unclear. This article aims to explore potential molecular mechanisms in UCEC and PCOS, as well as identify prognostic genes for UCEC.Methods: Bioinformatics methods were employed to screen for DEGs in UCEC and PCOS. The shared DEGs were analyzed by constructing a protein-protein interaction (PPI) network using the String database and Cytoscape software. The enrichment analysis was performed using Metascape. The shar
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11

Scholz, Markus, Katrin Horn, Janne Pott, et al. "X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements." Nature Communications 15, no. 1 (2024). http://dx.doi.org/10.1038/s41467-024-44709-1.

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AbstractX-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel s
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12

Huang, Pei-yan, Jun-guo Wu, Jun Gu, et al. "Bioinformatics analysis of miRNA and mRNA expression profiles to reveal the key miRNAs and genes in osteoarthritis." Journal of Orthopaedic Surgery and Research 16, no. 1 (2021). http://dx.doi.org/10.1186/s13018-021-02201-2.

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Abstract Background Osteoarthritis (OA) is a chronic degenerative joint disease and the most frequent type of arthritis. This study aimed to identify the key miRNAs and genes associated with OA progression. Methods The GSE105027 (microRNA [miRNA/miR] expression profile; 12 OA samples and 12 normal samples) and GSE48556 (messenger RNA [mRNA] expression profile; 106 OA samples and 33 normal samples) datasets were selected from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) and miRNAs (DEMs) were analyzed using the limma and ROCR packages in R, respectively. The targe
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13

Li, Xuehua, Qing Lin, Zhanwei Zhuang, et al. "Integrative pigGTEx resource with GWAS reveals genetic mechanism underlying semen quality in boars." Journal of Animal Science and Biotechnology 16, no. 1 (2025). https://doi.org/10.1186/s40104-025-01237-2.

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Abstract Background Semen quality is one of the most important indicators of boar reproductive performance. In the past, boar breeding has mostly emphasized characteristics such as lean meat percentage, feed conversion efficiency, and growth rate, while overlooking the genetic improvement of reproductive traits. This study employs advanced multi-omics approaches, such as transcriptome-wide association studies (TWAS) and colocalization between genome-wide association studies (GWAS) and expression quantitative trait loci (eQTLs), to provide a comprehensive understanding of the genetic mechanisms
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14

Jiao, Dongyue, Yingji Chen, Yalan Wang та ін. "DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs". Oncogene, 22 квітня 2022. http://dx.doi.org/10.1038/s41388-022-02319-5.

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15

Pla‐Prats, Carlos, Simone Cavadini, Georg Kempf, and Nicolas H. Thomä. "Recognition of the CCT5 di‐Glu degron by CRL4 DCAF12 is dependent on TRiC assembly." EMBO Journal, January 30, 2023. http://dx.doi.org/10.15252/embj.2022112253.

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16

Jiao, Dongyue, Yingji Chen, Yalan Wang та ін. "Editorial Expression of Concern: DCAF12 promotes apoptosis and inhibits NF-κB activation by acting as an endogenous antagonist of IAPs". Oncogene, 13 грудня 2024. https://doi.org/10.1038/s41388-024-03258-z.

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