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Journal articles on the topic 'DCD'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Chin, Jacky, D. Daruki, Singgih Juniawan, Dafid Mega Saputra, and Uti Roysen. "SIMULASI MODEL DISTRIBUSI PRODUK MAKANAN MENGGUNAKAN METODE SAVING MATRIX DAN MILK RUN PADA PERUSAHAAN FMCG DI KARAWANG." JISI: Jurnal Integrasi Sistem Industri 10, no. 1 (2023): 81. http://dx.doi.org/10.24853/jisi.10.1.81-87.

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Penelitian ini dilakukan pada Industri FMCG dan berfokus pada jalur distribusi dari perusahaan ke 18 DC yang menjadi kewajiban perusahaan. Tujuan penelitian ini adalah untuk mengetahui rute distribusi paling optimal dengan biaya distribusi paling minimal.Penelitian ini menggunakan model simulasi dengan Metode Saving Matrix untuk mengetahui kelompok distribusi dan Metode Milk Run untuk mengetahui jarak paling minimum. Besaran biaya dihitung dengan menghitung jarak tempuh tahunan pada setiap kelompok distribusi dengan biaya distribusi setiap kilometer jarak.Hasil penelitian menunjukan bahwa rute

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Maffei, I., F. Marani, G. Mazzeo, et al. "SHORT-TERM OUTCOMES OF HEART TRANSPLANT FROM DONATION AFTER CIRCULATORY DEATH VERSUS DONATION AFTER BRAIN DEATH." Journal of Cardiovascular Medicine 25, Supplement 1 (2024): e27. https://doi.org/10.2459/01.jcm.0001096432.66645.ea.

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Background and Aim: This study aims to compare the short-term outcomes of heart transplant (HT) from donors who died from brain death (DBD) versus those who died from circulatory death (DCD). Methods: This study includes adult patients who underwent HT from January 2023 to July 2024. Recipient characteristics, operative times, postoperative data, and length of hospital stay were compared. Results: A total of 34 patients were included (n=5 DCD, n=29 DBD). The two groups had similar median age (DBD 59 vs DCD 57; p=0.4). The cold ischemia time (DBD 170 min, DCD 84 min; p=0.002), cardiopulmonary b

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Levvey, Bronwyn. "Reflections on Australian DCD lung donation and transplant journey Report from the 38th Annual Meeting — International Society for Heart and Lung Transplantation, Nice, France: 11–14 April 2018." Transplant Journal of Australasia 28, Number 1 (2019): 15–19. http://dx.doi.org/10.33235/tja.28.1.15-19.

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‘10 Years On: The Significant Impact of Controlled DCD Lung Donors on Lung Transplant Opportunities and Outcomes’ Purpose Since 2006, the Alfred Hospital has increasingly utilised controlled DCD donor lungs to optimise LTx opportunities and reduced waiting list (WL) deaths. This study evaluated the impact of DCD donation on LTx WL time and mortality, and compared post-LTx outcomes of DCD and contemporaneous DBD LTx performed over the first 10 years. Method This was a retrospective analysis of all LTx done at our institution between May 2006 and February 2017 (n=696, 150 DCD LTx, 546 DBD LTx) w

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Parikh, Neehar D., Anton I. Skaro, Daniela P. Ladner, et al. "Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac Death." Gastroenterology Research and Practice 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/680316.

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Donation after cardiac death (DCD) has expanded in the last decade in the US; however, DCD liver utilization has flattened in recent years due to poor outcomes. We examined clinical and quality of life (QOL) outcomes of DCD recipients by conducting a retrospective and cross-sectional review of patients from 2003 to 2010. We compared clinical outcomes of DCD recipients (n=60) to those of donation after brain death (DBD) liver recipients (n=669) during the same time period. DCD recipients had significantly lower rates of 5-year graft survival (P<0.001) and a trend toward lower rates of 5-year

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Danion, Jérôme, Raphael Thuillier, Géraldine Allain, et al. "Evaluation of Liver Quality after Circulatory Death versus Brain Death: A Comparative Preclinical Pig Model Study." International Journal of Molecular Sciences 21, no. 23 (2020): 9040. http://dx.doi.org/10.3390/ijms21239040.

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The current organ shortage in hepatic transplantation leads to increased use of marginal livers. New organ sources are needed, and deceased after circulatory death (DCD) donors present an interesting possibility. However, many unknown remains on these donors and their pathophysiology regarding ischemia reperfusion injury (IRI). Our hypothesis was that DCD combined with abdominal normothermic regional recirculation (ANOR) is not inferior to deceased after brain death (DBD) donors. We performed a mechanistic comparison between livers from DBD and DCD donors in a highly reproducible pig model, cl

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Wisel, Steven A., Justin A. Steggerda, Carrie Thiessen, et al. "Preserved 2-y Liver Transplant Outcomes Following Simultaneous Thoracoabdominal DCD Organ Procurement Despite Effects on Liver Utilization Rate." Transplantation Direct 9, no. 11 (2023): e1528. http://dx.doi.org/10.1097/txd.0000000000001528.

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Background. Current techniques for donation after circulatory determination of death (DCD) heart procurement, through either direct procurement and machine perfusion or thoracoabdominal normothermic regional perfusion (NRP), have demonstrated excellent heart transplant outcomes. However, the impact of thoracoabdominal DCD (TA-DCD) heart procurement on liver allograft outcomes and utilization is poorly understood. Methods. One hundred sixty simultaneous heart and liver DCD donors were identified using the United Network for Organ Sharing/Organ Procurement and Transplantation Network database be

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7

Burgess, Mark, Laura Silsby, Susanna Madden, et al. "Eligible DBD Donors Proceeding via the DCD Pathway: Incidence, Cause, and Outcomes in the United Kingdom." Transplantation Direct 11, no. 7 (2025): e1804. https://doi.org/10.1097/txd.0000000000001804.

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Background. Eligible donation after brain death (DBD) donors may rarely proceed via the donation after circulatory death (DCD) pathway. The incidence, reasons for pathway divergence, and graft and recipient outcomes in the United Kingdom of this cohort are unknown. We aimed to establish the incidence of eligible DBD to DCD donors in the United Kingdom, the reasons for pathway divergence, organ donation and utilization rates, and the renal graft and recipient outcomes for this cohort. Methods. UK electronic and article records were reviewed for all eligible DBD donors proceeding via the DCD pat

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Croome, Kris P., Vivian McAlister, Paul Adams, Paul Marotta, William Wall, and Roberto Hernandez-Alejandro. "Endoscopic Management of Biliary Complications following Liver Transplantation after Donation from Cardiac Death Donors." Canadian Journal of Gastroenterology 26, no. 9 (2012): 607–10. http://dx.doi.org/10.1155/2012/346286.

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BACKGROUND Previous studies have shown a higher incidence of biliary complications following donation after cardiac death (DCD) liver transplantation compared with donation after brain death (DBD) liver transplantation. The endoscopic management of ischemic type biliary strictures in patients who have undergone DCD liver transplants needs to be characterized further.METHODS: A retrospective institutional review of all patients who underwent DCD liver transplant from January 2006 to September 2011 was performed. These patients were compared with all patients who underwent DBD liver transplantat

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Gori, Francesca, Jacopo Fumagalli, Caterina Lonati, et al. "Lung Biomolecular Profile and Function of Grafts from Donors after Cardiocirculatory Death with Prolonged Donor Warm Ischemia Time." Journal of Clinical Medicine 11, no. 11 (2022): 3066. http://dx.doi.org/10.3390/jcm11113066.

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The acceptable duration of donor warm ischemia time (DWIT) after cardiocirculatory death (DCD) is still debated. We analyzed the biomolecular profile and function during ex vivo lung perfusion (EVLP) of DCD lungs and their correlation with lung transplantation (LuTx) outcomes. Donor data, procurement times, recipient outcomes, and graft function up to 1 year after LuTx were collected. During EVLP, the parameters of graft function and metabolism, perfusate samples to quantify inflammation, glycocalyx breakdown products, coagulation, and endothelial activation markers were obtained. Data were co

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Groba Marco, Maria del Val, Miriam Cabrera Santana, Mario Galvan Ruiz, et al. "Expanding Horizons in Cardiac Transplant: Efficacy and Outcomes of Circulatory and Brain Death Donor Hearts in a Newly Implemented Cardiac Transplant Program with Limited Donor Accessibility and a Literature Review." Journal of Clinical Medicine 13, no. 17 (2024): 4972. http://dx.doi.org/10.3390/jcm13174972.

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(1) Background: Cardiac donation after circulatory death (DCD) is an emerging paradigm in organ transplantation. However, this technique is recent and has only been implemented by highly experienced centers. This study compares the characteristics and outcomes of thoraco-abdominal normothermic regional perfusion (TANRP) and static cold-storage DCD and traditional donation after brain death (DBD) cardiac transplants (CT) in a newly stablished transplant program with restricted donor availability. (2) Method: We performed a retrospective, single-center study of all adult patients who underwent a

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Dweck, Albert, Korri S. Hershenhouse, Mayuko Uehara, Tadahisa Sugiura, and Brandon E. Ferrell. "The Current Landscape of Donation After Circulatory Death Heart Transplantation—Where Do We Stand?" Transplantology 6, no. 2 (2025): 11. https://doi.org/10.3390/transplantology6020011.

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The growing disparity between the demand for donor hearts and their availability has reignited interest in donation after circulatory death (DCD) heart transplantation. Historically, DCD heart transplantation has been overshadowed by donation after brain death (DBD) due to ethical and preservation challenges. However, recent advancements in procurement techniques allow for evaluation of the donor heart and enable the broader utilization of DCD donors. While challenges remain, early outcomes suggest comparable survival rates between DCD and DBD heart transplantation. This review provides a comp

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Zwaini, Zinah, Meeta Patel, Cordula Stover, et al. "Comparative Analysis of Risk Factors in Declined Kidneys from Donation after Brain Death and Circulatory Death." Medicina 56, no. 6 (2020): 317. http://dx.doi.org/10.3390/medicina56060317.

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Background and objectives: Kidneys from donation after circulatory death (DCD) are more likely to be declined for transplantation compared with kidneys from donation after brain death (DBD). The aim of this study was to evaluate characteristics in the biopsies of human DCD and DBD kidneys that were declined for transplantation in order to rescue more DCD kidneys. Materials and Methods: Sixty kidney donors (DCD = 36, DBD = 24) were recruited into the study and assessed using donor demographics. Kidney biopsies taken post cold storage were also evaluated for histological damage, inflammation (my

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Kostakis, Ioannis D., Theodoros Kassimatis, Clare Flach, Nikolaos Karydis, Nicos Kessaris, and Ioannis Loukopoulos. "Hypoperfusion warm ischaemia time in renal transplants from donors after circulatory death." Nephrology Dialysis Transplantation 35, no. 9 (2020): 1628–34. http://dx.doi.org/10.1093/ndt/gfaa160.

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Abstract Background The donor hypoperfusion phase before asystole in renal transplants from donors after circulatory death (DCD) has been considered responsible for worse outcomes than those from donors after brain death (DBD). Methods We included 10 309 adult renal transplants (7128 DBD and 3181 DCD; 1 January 2010–31 December 2016) from the UK Transplant Registry. We divided DCD renal transplants into groups according to hypoperfusion warm ischaemia time (HWIT). We compared delayed graft function (DGF) rates, primary non-function (PNF) rates and graft survival among them using DBD renal tran

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Chen, Wei, Dipesh Kumar Yadav, Xueli Bai, et al. "Liver Transplantation from Voluntary Organ Donor System in China: A Comparison between DBD and DCD Liver Transplants." Gastroenterology Research and Practice 2019 (May 2, 2019): 1–7. http://dx.doi.org/10.1155/2019/5736702.

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Background. In China, the cases of liver transplantation (LT) from donation after citizens’ death have rose year by year since the citizen-based voluntary organ donor system was initiated in 2010. The objective of our research was to investigate the early postoperative and late long-term outcomes of LT from donation after brain death (DBD) and donation after circulatory death (DCD) according to the current organ donation system in China. Methods. Sixty-two consecutive cases of LT from donation after citizens’ death performed in our hospital between February 2012 and June 2017 were examined ret

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Hofmann, Julia, Andras T. Meszaros, Madita L. Buch, et al. "Bioenergetic and Cytokine Profiling May Help to Rescue More DCD Livers for Transplantation." International Journal of Molecular Sciences 24, no. 11 (2023): 9536. http://dx.doi.org/10.3390/ijms24119536.

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The majority of organs used for liver transplantation come from brain-dead donors (DBD). In order to overcome the organ shortage, increasingly donation after circulatory death (DCD) organs are also considered. Since normothermic machine perfusion (NMP) restores metabolic activity and allows for in-depth assessment of organ quality and function prior to transplantation, such organs may benefit from NMP. We herein compare the bioenergetic performance through a comprehensive evaluation of mitochondria by high-resolution respirometry in tissue biopsies and the inflammatory response in DBD and DCD

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De Paep, Diedert L., Freya Van Hulle, Zhidong Ling, et al. "Utility of Islet Cell Preparations From Donor Pancreases After Euthanasia." Cell Transplantation 31 (January 2022): 096368972210961. http://dx.doi.org/10.1177/09636897221096160.

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Patients fulfilling criteria for euthanasia can choose to donate their organs after circulatory death [donors after euthanasia (DCD V)]. This study assesses the outcome of islet cell isolation from DCD V pancreases. A procedure for DCD V procurement provided 13 pancreases preserved in Institut Georges Lopez-1 preservation solution and following acirculatory warm ischemia time under 10 minutes. Islet cell isolation outcomes are compared with those from reference donors after brain death (DBD, n = 234) and a cohort of donors after controlled circulatory death (DCD III, n = 29) procured under the

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Wisel, Steven A., Justin A. Steggerda, and Irene K. Kim. "Use of Machine Perfusion in the United States Increases Organ Utilization and Improves DCD Graft Survival in Liver Transplantation." Transplantation Direct 10, no. 12 (2024): e1726. http://dx.doi.org/10.1097/txd.0000000000001726.

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Background. Adoption of machine perfusion (MP) technology has rapidly expanded in liver transplantation without real-world data on utilization and outcomes, which are critical to understand the appropriate application of MP technology. Methods. The Organ Procurement and Transplant Network/Standard Transplant Analysis and Research database was used to identify all deceased donor livers procured with intent for transplant between October 27, 2015 (date of first recorded MP) and June 30, 2023 (n = 67 795). Liver allografts were cohorted by donation after brain death (DBD; n = 59 957) or circulato

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Wells, Malcolm, Kris Croome, Toni Janik, Roberto Hernandez-Alejandro, and Natasha Chandok. "Comparing Outcomes of Donation After Cardiac Death Versus Donation After Brain Death in Liver Transplant Recipients with Hepatitis C: A Systematic Review and Meta-Analysis." Canadian Journal of Gastroenterology and Hepatology 28, no. 2 (2014): 103–8. http://dx.doi.org/10.1155/2014/421451.

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BACKGROUND: Liver transplantation (LT) using organs donated after cardiac death (DCD) is increasing due, in large part, to a shortage of organs. The outcome of using DCD organs in recipients with hepatits C virus (HCV) infection remains unclear due to the limited experience and number of publications addressing this issue.OBJECTIVE: To evaluate the clinical outcomes of DCD versus donation after brain death (DBD) in HCV-positive patients undergoing LT.METHODS: Studies comparing DCD versus DBD LT in HCV-positive patients were identified based on systematic searches of seven electronic databases

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Akande, Oluwatoyin, Qun Chen, Stefano Toldo, Edward J. Lesnefsky, and Mohammed Quader. "Ischemia and reperfusion injury to mitochondria and cardiac function in donation after circulatory death hearts- an experimental study." PLOS ONE 15, no. 12 (2020): e0243504. http://dx.doi.org/10.1371/journal.pone.0243504.

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The ultimate treatment for patients with end-stage heart failure is heart transplantation. The number of donor hearts which are primarily procured from donation after brain death (DBD) donors is limited, but donation after circulatory death (DCD) donor hearts can increase the heart donor pool. However, ischemia and reperfusion injuries associated with the DCD process causes myocardial damage, limiting the use of DCD hearts in transplantation. Addressing this problem is critical in the exploration of DCD hearts as suitable donor hearts for transplantation. In this study, rat hearts were procure

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Palomo-López, Nora, Ana Rodríguez-Rodríguez, Luis Martín-Villén, et al. "Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results." Healthcare 10, no. 5 (2022): 762. http://dx.doi.org/10.3390/healthcare10050762.

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The objective was to quantify oxidative stress resulting from ischemia during the donation process, using malondialdehyde (MDA) measurement, and its modulation by the administration of melatonin. We designed a triple-blind clinical trial with donors randomized to melatonin or placebo. We collected donors by donation after brain death (DBD) and controlled donation after circulatory death (DCD), the latter maintained by normothermic regional perfusion (NRP). Melatonin or placebo was administered prior to donation or following limitation of therapeutic effort (LTE). Demographic variables and medi

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Levvey, Bronwyn, Kovi Levin, Miranda Paraskeva, Glen Westall, and Gregory Snell. "Donation after Brain Death versus Donation after Circulatory Death: Lung Donor Management Issues." Seminars in Respiratory and Critical Care Medicine 39, no. 02 (2018): 138–47. http://dx.doi.org/10.1055/s-0037-1615820.

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AbstractLung transplantation (LTx) has traditionally been limited by a lack of suitable donor lungs. With the recognition that lungs are more robust than initially thought, the size of the donor pool of available lungs has increased dramatically in the past decade. Donation after brain death (DBD) and donation after circulatory death (DCD) lungs, both ideal and extended are now routinely utilized. DBD lungs can be damaged. There are important differences in the public's understanding, legal and consent processes, intensive care unit strategies, lung pathophysiology, logistics, and potential-to

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De Paep, Diedert L., Freya Van Hulle, Zhidong Ling, et al. "Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution." PLOS ONE 16, no. 5 (2021): e0251055. http://dx.doi.org/10.1371/journal.pone.0251055.

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Organs from donors after controlled circulatory death (DCD III) exhibit a higher risk for graft dysfunction due to an initial period of warm ischemia. This procurement condition can also affect the yield of beta cells in islet isolates from donor pancreases, and hence their use for transplantation. The present study uses data collected and generated by our Beta Cell Bank to compare the number of beta cells in isolates from DCD III (n = 141) with that from donors after brain death (DBD, n = 609), before and after culture, and examines the influence of donor and procurement variables. Beta cell

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Oki, Rikako, Emily Kerby, Ingrid Rocha, et al. "The Impact of Normothermic Machine Perfusion on Biliary Complications in Donation After Circulatory Death Donor Liver Transplantation." Transplantation Direct 11, no. 7 (2025): e1821. https://doi.org/10.1097/txd.0000000000001821.

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Background. The incidence of ischemic cholangiopathy (IC) in liver transplant (LT) patients from donation after circulatory death (DCD) has been observed to be higher compared with those from donation after brain death (DBD). It has been reported that the normothermic machine perfusion (NMP) technique was associated with lower rates of IC. However, the effect of NMP on anastomotic biliary complications remains unclear. Methods. A total of 450 LTs performed between January 2019 and December 2023 were analyzed in a retrospective study. The primary outcome included biliary complications within 18

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Dhyanti, Yustina, Khairul Munadi, and Fitri Arnia. "Penerapan Deskriptor Warna Dominan untuk Temu Kembali Citra Busana pada Peranti Bergerak." Jurnal Rekayasa Elektrika 12, no. 3 (2016): 104. http://dx.doi.org/10.17529/jre.v12i3.5701.

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Nowadays, clothes with various designs and color combinations are available for purchasing through an online shop, which is mostly equipped with keyword-based item retrieval. Here, the object in the online database is retrieved based on the keyword inputted by the potential buyers. The keyword-based search may bring potential customers on difficulties to describe the clothes they want to buy. This paper presents a new searching approach, using an image instead of text, as the query into an online shop. This method is known as content-based image retrieval (CBIR). Particularly, we focused on us

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Hakeem, A., S. Raza, S. Khan, et al. "Economic Analysis of DBD Versus DCD Kidney Transplantation - Is Higher DCD Costs Justified?" Transplantation Journal 94, no. 10S (2012): 184. http://dx.doi.org/10.1097/00007890-201211271-00343.

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Li, Huizhen, Xin Ma, Jian Li, Yanchun Zhang, Yongnan Li, and Xiangyang Wu. "Heart Transplantation Post-donation After Circulatory Death: Current Status and Future Potential." Heart Surgery Forum 28, no. 6 (2025): E494—E509. https://doi.org/10.59958/hsf.8519.

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Heart transplantation enhances the quality of life and survival rate of patients with end-stage heart failure. However, the biggest obstacle remains the insufficient supply of cardiac grafts, which has caused the global waitlist for heart transplants to increase. Subsequently, donation after circulatory death (DCD) has emerged as a potential solution to alleviate the insufficient supply of cardiac grafts, potentially offering new opportunities for terminally ill patients. Over the past five years, the number of DCD heart transplants has increased, with increasing success rates reported by orga

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Avsec, Danica, and Jana Šimenc. "Donorski program po cirkulacijski smrti v Sloveniji: Analiza stališč strokovne javnosti in njihov nadaljnji razvoj." Slovenian Medical Journal 89, no. 5-6 (2020): 255–67. http://dx.doi.org/10.6016/zdravvestn.2974.

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Izhodišče: Poleg prevladujočega odvzema organov in tkiv za namen zdravljenja po potrjenih nevroloških merilih oz. možganski smrti (angl. donation after brain death, DBD) pa število evropskih držav, ki vzpostavljajo programe odvzema po cirkulacijski smrti (angl. donation after circulatory death, DCD), vztrajno narašča. V zadnjih letih je DCD postala izpostavljena tema v donorski medicini, v praksi držav pa je moč prepoznati več različnih pravnih okvirov in medicinskih vidikov DCD-programov. V Sloveniji se DCD še ne izvaja. Slovenija-transplant je nacionalna pristojna ustanova, ki med drugim vod

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Heeley, Benjamin, Laurence Hodierne, Ian Johnson, and Dale Gardiner. "A Single-center Exploration of Attitudes to Deceased Organ Donation Over Time Among Healthcare Staff in Intensive Care." Transplantation Direct 9, no. 12 (2023): e1557. http://dx.doi.org/10.1097/txd.0000000000001557.

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Background. Changes to deceased organ donation in the United Kingdom, including establishment of the specialist nurse for organ donation (SNOD) role, have resulted in increased numbers of donations. Have increasing numbers of donations altered attitudes among intensive care unit (ICU) healthcare professionals (ICU staff) to organ donation over time? Methods. A written survey of ICU staff at Nottingham University Hospitals National Health Service Trust was conducted across 2 wk in 2015, 2018, and 2020 (pre–COVID-19). Participants were asked to submit descriptors (words/phrases) they associated

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Ge, Ying, Li-Wei Xu, Ya Liu та ін. "Dithiocarbamate as a Valuable Scaffold for the Inhibition of Metallo-β-Lactmases". Biomolecules 9, № 11 (2019): 699. http://dx.doi.org/10.3390/biom9110699.

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The ‘superbug’ infection caused by metallo-β-lactamases (MβLs) has grown into an emergent health threat. Given the clinical importance of MβLs, a novel scaffold, dithiocarbamate, was constructed. The obtained molecules, DC1, DC8 and DC10, inhibited MβLs NDM-1, VIM-2, IMP-1, ImiS and L1 from all three subclasses, exhibiting an IC50 < 26 μM. DC1 was found to be the best inhibitor of ImiS (IC50 < 0.22 μM). DC1-2, DC4, DC8 and DC10 restored antimicrobial effects of cefazolin and imipenem against E. coli-BL21, producing NDM-1, ImiS or L1, and DC1 showed the best inhibition of E. coli cells, e

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Saemann, Lars, Adrian-Iustin Georgevici, Fabio Hoorn, et al. "Improving Diastolic and Microvascular Function in Heart Transplantation with Donation after Circulatory Death." International Journal of Molecular Sciences 24, no. 14 (2023): 11562. http://dx.doi.org/10.3390/ijms241411562.

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The impact of the machine perfusion of donation after circulatory death (DCD) hearts with the novel Custodiol-N solution on diastolic and coronary microvascular dysfunction is unknown. Porcine DCD-hearts were maintained four hours by perfusion with normothermic blood (DCD-B), hypothermic Custodiol (DCD-C), or Custodiol-N (DCD-CN), followed by one hour of reperfusion with fresh blood, including microvascular and contractile evaluation. In another group (DCD group), one hour of reperfusion, including microvascular and contractile evaluation, was performed without a previous maintenance period (a

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Meier, Raphael Pascal Henri, Yvonne Kelly, Hillary Braun, et al. "Comparison of Biliary Complications Rates After Brain Death, Donation After Circulatory Death, and Living-Donor Liver Transplantation: A Single-Center Cohort Study." Transplant International 35 (December 9, 2022). http://dx.doi.org/10.3389/ti.2022.10855.

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Donation-after-circulatory-death (DCD), donation-after-brain-death (DBD), and living-donation (LD) are the three possible options for liver transplantation (LT), each with unique benefits and complication rates. We aimed to compare DCD-, DBD-, and LD-LT-specific graft survival and biliary complications (BC). We collected data on 138 DCD-, 3,027 DBD- and 318 LD-LTs adult recipients from a single center and analyzed patient/graft survival. BC (leak and anastomotic/non-anastomotic stricture (AS/NAS)) were analyzed in a subset of 414 patients. One-/five-year graft survival were 88.6%/70.0% for DCD

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Slagter, Julia S., Hendrikus J. A. N. Kimenai, Jacqueline van de Wetering, et al. "Kidney Transplant Outcome Following Donation After Euthanasia." JAMA Surgery, September 25, 2024. http://dx.doi.org/10.1001/jamasurg.2024.3913.

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ImportanceIn the Netherlands, organ donation after euthanasia (donation after circulatory death type V [DCD-V]) has been increasingly performed since 2012. However, the outcomes of DCD-V kidney grafts have not been thoroughly investigated. It is critical to assess the outcomes of these kidney grafts to ascertain whether DCD-V is a safe and valuable way to increase the kidney donor pool.ObjectivesTo investigate the outcomes of DCD-V kidney transplantation and compare them with outcomes of kidney transplantation after circulatory death after withdrawal of life-sustaining therapies (DCD type III

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Punjala, Sai Rithin, April J. Logan, Jayanthan Subramanian, et al. "Outcomes of Liver Transplantation From Hepatitis C Virus–positive DCD Donors and Its Utilization Among Centers in the United States." Transplantation, August 22, 2024. http://dx.doi.org/10.1097/tp.0000000000005174.

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Background. Donation after circulatory death (DCD) or hepatitis C virus (HCV+) liver grafts are underused among transplant centers in the United States. The study aimed to evaluate organ utilization and outcomes of liver grafts from DCD donors with HCV infection. Methods. National registry and local center data of all deceased donor liver transplants performed between November 2016 and December 2021 were analyzed. All transplants were divided into 4 groups: HCV– DCD, HCV– donation after brain death [DBD], HCV+ DCD, and HCV+ DBD. The outcome of interest was 1-y graft survival. Results. Out of 1

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Bobba, Christopher M., Bryan A. Whitson, Matthew C. Henn, et al. "Trends in Donation After Circulatory Death in Lung Transplantation in the United States: Impact Of Era." Transplant International 35 (April 4, 2022). http://dx.doi.org/10.3389/ti.2022.10172.

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Background: Use of lungs donated after circulatory death (DCD) has expanded, but changes in donor/recipient characteristics and comparison to brain dead donors (DBD) has not been studied. We examined the evolution of the use of DCD lungs for transplantation and compare outcomes to DBD lungs.Methods: The SRTR database was used to construct three 5-year intervals. Perioperative variables and survival were compared by era and for DCD vs. DBD. Geographic variation was estimated using recipient permanent address.Results: 728 DCD and 27,205 DBD lung transplants were identified. DCD volume increased

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Nguyen, Michelle C., Chi Zhang, Yu-Hui Chang, et al. "Improved Outcomes and Resource Use With Normothermic Machine Perfusion in Liver Transplantation." JAMA Surgery, January 29, 2025. https://doi.org/10.1001/jamasurg.2024.6520.

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ImportanceNormothermic machine perfusion (NMP) has been shown to reduce peritransplant complications. Despite increasing NMP use in liver transplant (LT), there is a scarcity of real-world clinical experience data.ObjectiveTo compare LT outcomes between donation after brain death (DBD) and donation after circulatory death (DCD) allografts preserved with NMP or static cold storage (SCS).Design, Setting, and ParticipantsThis single-center, retrospective observational cohort study included all consecutive adult LTs performed between January 2019 and December 2023 at the Mayo Clinic in Arizona. Da

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Zong, Junjie, Weicong Ye, Jizhang Yu, et al. "Outcomes of Heart Transplantation From Donation After Circulatory Death: An Up-to-Date Systematic Meta-analysis." Transplantation, April 5, 2024. http://dx.doi.org/10.1097/tp.0000000000005017.

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Background. Donation after circulatory death (DCD) heart transplantation (HTx) significantly expands the donor pool and reduces waitlist mortality. However, high-level evidence-based data on its safety and effectiveness are lacking. This meta-analysis aimed to compare the outcomes between DCD and donation after brain death (DBD) HTxs. Methods. Databases, including MEDLINE, Embase, CINAHL, and the Cochrane Central Register of Controlled Trials, were systematically searched for randomized controlled trials and observational studies reporting the outcomes of DCD and DBD HTxs published from 2014 o

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Song, Melinda, Amy Fiedler, Jason Smith, Liviu Klein, and Mandar Aras. "Abstract 4147352: Donation After Circulatory Death Is Associated with Increased Morbidity and Mortality in Heart Transplant Patients Supported by Mechanical Circulatory Support Devices." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4147352.

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Background: In recent years, both mechanical circulatory support devices (MCSD) and grafts from donation after circulatory death (DCD) are increasingly utilized for patients undergoing heart transplant. Multiple studies have demonstrated no difference in outcomes for DCD recipients compared to donation after brain death (DBD). To date, no study has examined whether outcomes remain similar among patients supported with MCSD pre-transplant. Methods: Using the United Network for Organ Sharing database, adult patients who underwent single-organ heart transplant from 12/1/2019 to 12/31/2023 were id

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Bleszynski, Michael S., Catherine Parmentier, Alejandro Torres-Hernandez, et al. "Pancreas transplantation with grafts obtained from donation after cardiac death or donation after brain death results in comparable outcomes." Frontiers in Transplantation 2 (August 9, 2023). http://dx.doi.org/10.3389/frtra.2023.1176398.

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IntroductionPancreas organ shortages and long recipient waitlist times are critical components that limit recipients from receiving a pancreas transplant. Over the last decade, our center has been using donation after cardiac death (DCD) donors as an adjunct to donation after brain death (DBD) donors to expand the organ pool. The aim of this study was to compare recipient and graft survival between DCD and DBD recipients.MethodsA retrospective single center propensity matched analysis (2011–2020) of 32 DCD vs 96 DBD pancreas transplants was performed.Results8-year recipient survival was simila

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Gopal, Jeevan Prakash, Adam McLean, and Anand Muthusamy. "Metabolic Outcomes After Pancreas Transplant Alone From Donation After Circulatory Death Donors-The UK Transplant Registry Analysis." Transplant International 36 (May 17, 2023). http://dx.doi.org/10.3389/ti.2023.11205.

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Extrapolating data from early DCD (donation after circulatory death) kidney transplantation, pancreas transplants from DCD grafts were feared to have worse metabolic outcomes. Hence, we aimed to address the question of pancreas transplant alone (PTA) from DCD donors–are our concerns justified? A UK transplant registry analysis of 185 PTA performed between 2005 and 2018 was done. All early graft losses (&lt;3 months) were excluded to allow focus on the metabolic outcomes (HbA1c, weight gain and incidence of secondary diabetic macrovascular complications). The aim was to compare the metaboli

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Stehlik, Josef, Maryjane A. Farr, Mandeep R. Mehra, et al. "Clinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry." Circulation, March 7, 2025. https://doi.org/10.1161/circulationaha.124.071743.

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BACKGROUND: A preservation system, the Organ Care System (OCS; TransMedics) uses normothermic pulsatile perfusion during organ transport for heart transplantation. This system has demonstrated favorable outcomes in hearts recovered from extended-criteria donors after brain death (DBD) and donors after circulatory death (DCD). METHODS: The OCS Heart Perfusion Registry collects data on US heart transplantations using the OCS, static cold storage (SCS), or thoracoabdominal normothermic regional perfusion (NRP) recovered from DBD or DCD donors. We analyzed donor and recipient characteristics and p

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Bhandari, Krishna, Jennie Kwon, Atsuko Uehara, et al. "Abstract 4138936: Outcomes of Over 1,000 Heart Transplants Using Donation After Circulatory Death Donors in the United States." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4138936.

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Introduction: Heart transplantation (HT) with donation after circulatory death (DCD) donors has been increasing exponentially since its resurgence in the US. The aim of this study was to evaluate national outcomes of DCD HT. Methods: Adult HT recipients from 2019-2023 were identified from the United Network Organ Sharing registry. Patients were categorized based on donor-type (donation after brain death [DBD] or DCD). Kaplan-Meier and multivariable Cox regression analyses were used for survival. A propensity-matched analysis was also performed. A further sub-analysis was conducted comparing ou

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Zhou, Angela L., Suseela Raj, Ekaterina Fedorova, et al. "Postkidney Transplant Delayed Graft Function Outcomes Are Not Worsened by Deceased Donor Type." Clinical Transplantation 39, no. 6 (2025). https://doi.org/10.1111/ctr.70199.

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ABSTRACTIntroductionKidney‐delayed graft function (DGF) is more common in donation after circulatory death (DCD) donors in comparison to donatation after brain death (DBD). We analyzed deceased kidney transplant recipients (DDKTR) at our center between 2005 and 2019, stratified by donor type (DBD vs. DCD).MethodsWe assessed risk factors for DGF, acute rejection (AR), graft failure (GF), along with the death with functioning graft (DWFG), and the interaction between types of donors for those complications.ResultsAmong 2543 DDKTRs, 804 (32%) were from DCD donors. Older donor age, higher recipien

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Palleschi, Alessandro, Alberto Zanella, Giuseppe Citerio, et al. "Lung Transplantation From Controlled and Uncontrolled Donation After Circulatory Death (DCD) Donors With Long Ischemic Times Managed by Simple Normothermic Ventilation and Ex-Vivo Lung Perfusion Assessment." Transplant International 36 (February 8, 2023). http://dx.doi.org/10.3389/ti.2023.10690.

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Donation after cardiac death (DCD) donors are still subject of studies. In this prospective cohort trial, we compared outcomes after lung transplantation (LT) of subjects receiving lungs from DCD donors with those of subjects receiving lungs from donation after brain death (DBD) donors (ClinicalTrial.gov: NCT02061462). Lungs from DCD donors were preserved in-vivo through normothermic ventilation, as per our protocol. We enrolled candidates for bilateral LT ≥14 years. Candidates for multi-organ or re-LT, donors aged ≥65 years, DCD category I or IV donors were excluded. We recorded clinical data

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Ayer, Austin, Lauren Truby, Jacob Schroder, et al. "Abstract 11945: Improved Outcomes in Severe Primary Graft Dysfunction Following Heart Transplantation With Donation After Circulatory Death Compared to Donation After Brain Death." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.11945.

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Introduction: Primary graft dysfunction (PGD), the leading cause of early mortality after heart transplant, is more common following heart donation after circulatory death (DCD) than following donation after brain death (DBD). We conducted a single-center, retrospective cohort study to compare the incidence, severity, and outcomes of patients experiencing PGD after DCD compared to DBD heart transplant. Methods: We reviewed the medical records of all adult heart transplant recipients at our institution between March 2016 and December 2021. Patients undergoing multi-organ transplant were exclude

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Fallani, Guido, Alberto Stocco, Antonio Siniscalchi, et al. "Beyond the Concepts of Elder and Marginal in DCD Liver Transplantation: A Prospective Observational Matched-Cohort Study in the Italian Clinical Setting." Transplant International 36 (September 7, 2023). http://dx.doi.org/10.3389/ti.2023.11697.

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Donation after circulatory determination of death (DCD) is a valuable strategy to increase the availability of grafts for liver transplantation (LT). As the average age of populations rises, the donor pool is likely to be affected by a potential increase in DCD donor age in the near future. We conducted a prospective cohort study to evaluate post-transplantation outcomes in recipients of grafts from elderly DCD donors compared with younger DCD donors, and elderly donors after brainstem determination of death (DBD). From August 2020 to May 2022, consecutive recipients of deceased donor liver-on

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Ciarka, A., A. Page, S. Messer, et al. "Donation after circulatory death hearts recipients compared to donation after brain death heart recipients have comparable systolic left ventricular function and better myocardial strain at 1 year." European Heart Journal 41, Supplement_2 (2020). http://dx.doi.org/10.1093/ehjci/ehaa946.1108.

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Abstract Purpose Cardiac transplantation from donation after circulatory death (DCD) has been implemented at our hospital since February 2015. Despite encouraging results some concerns may be raised about the impact of the warm ischemia and reperfusion injury on the myocardium status at longer follow-up. Therefore, we aimed to analyse systolic performance of the left ventricle at 1 year follow in DCD and donation after brain death (DBD) cardiac recipients, as assessed by echocardiography with myocardial deformation imaging. Methods We identified 46 consecutive DCD cardiac recipients who were t

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Merani, Shaheed, Marian Urban, Scott G. Westphal, et al. "Improved Early Post-Transplant Outcomes and Organ Use in Kidney Transplant Using Normothermic Regional Perfusion for Donation after Circulatory Death: National Experience in the US." Journal of the American College of Surgeons, September 29, 2023. http://dx.doi.org/10.1097/xcs.0000000000000880.

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Background: Normothermic regional perfusion (NRP) is a technique that is intended to enhance organ transplant outcomes from donation circulatory death (DCD) donors. Study Design: A retrospective analysis of data from the Scientific Registry of Transplant Recipients (SRTR) was performed. DCD donors were screened for inclusion based on date of donation 2020 or later, and whether the heart was also recovered for transplantation. We grouped donors as either donation after brain death (DBD) or DCD. DCD donors were further divided into groups including those in which the heart was not recovered for

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Cheshire, Caitlin, Ismail Vokshi, Jason Ali, et al. "Abstract 13053: Cardiac Allograft Vasculopathy Following Donation After Circulatory-Determined Death Heart Transplantation." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.13053.

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Introduction: Cardiac allograft vasculopathy (CAV) remains a major problem for heart transplant (HTx) recipients, limiting their long-term survival. Our centre has performed the world’s largest series of donation after circulatory-determined death (DCD) HTx. Five-year survival is equivalent to donation after brainstem-determined death (DBD) HTx. However, there is no information on CAV in DCD HTx recipients. We sought to evaluate the incidence of CAV in our cohort of DCD HTx recipients. Methods: All DCD HTx recipients at our centre between February 2015 and December 2019 who had undergone CAV s

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Kwon, Ye In Christopher, Michael Keller, Kareem Elhigzi, et al. "Early Outcomes of Primary Graft Dysfunction Comparing Donation After Circulatory and Brain Death Heart Transplantation: An Analysis of the UNOS Registry." Clinical Transplantation 39, no. 7 (2025). https://doi.org/10.1111/ctr.70222.

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ABSTRACTBackgroundPrimary graft dysfunction (PGD) represents a leading cause of mortality in patients undergoing donation after brain death (DBD) orthotopic heart transplantation (OHT), requiring timely escalation to mechanical circulatory support. There is a lack of nationwide data regarding PGD after donation after circulatory death (DCD). Here, we evaluated the incidence and short‐term outcomes of PGD following DCD.MethodsUsing the UNOS registry between 9/2023 and 9/2024, we identified all adult (≥18 years) recipients of OHT. The incidence and outcomes of moderate‐severe PGD (24‐ and 72‐h p

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Coelho, Tiago Pinto, Pauline Erpicum, Margaux Navez, et al. "#3687 KIDNEY TRANSCRIPTOME VARIES BETWEEN DONOR TYPES, WITH A DIFFERENTIAL REPONSE TO ISCHEMIC PRECONDITIONING." Nephrology Dialysis Transplantation 38, Supplement_1 (2023). http://dx.doi.org/10.1093/ndt/gfad063c_3687.

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Abstract Background and Aims The prevention/attenuation of graft ischemic injury is a challenge in kidney transplantation. We developed two rat models to investigate the impact of mesenchymal stromal cells (MSCs) in the ischemic preconditioning of kidneys from Donors after Circulatory Death (DCD) and Donors after Brain Death (DBD). Method Under general anesthesia, rats underwent iv injection of saline (S-groups) or 1.5 106 MSCs (MSC-groups) followed by either DBD (6hr of brain death) or DCD (6hr of anesthesia and 20min warm ischemia) models, resulting in 4 groups (S-DBD, S-DCD, MSC-DBD, MSC-DC

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