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Journal articles on the topic 'Dd4 gene'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

SHIRAISHI, Hiroaki, Syuhei ISHIKURA, Kazuya MATSUURA, et al. "Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA." Biochemical Journal 334, no. 2 (1998): 399–405. http://dx.doi.org/10.1042/bj3340399.

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Human liver contains three isoforms (DD1, DD2 and DD4) of dihydrodiol dehydrogenase with 20α- or 3α-hydroxysteroid dehydrogenase activity; the dehydrogenases belong to the aldo–oxo reductase (AKR) superfamily. cDNA species encoding DD1 and DD4 have been identified. However, four cDNA species with more than 99% sequence identity have been cloned and are compatible with a partial amino acid sequence of DD2. In this study we have isolated a cDNA clone encoding DD2, which was confirmed by comparison of the properties of the recombinant and hepatic enzymes. This cDNA showed differences of one, two,

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2

Lazarev, Maxim, and Tatyana Laskina. "Use of the method of homologous recombination for site-directed mutagenesis of the drosophila-d4 gene of Drosophila melanogaster." Actual Problems of Medicine and Biology, no. 2 (December 31, 2021): 22–38. https://doi.org/10.5281/zenodo.6475527.

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This work is devoted to the analysis of translocation from the genetic construct of the DNA fragment of the mutant dd4 gene in the Drosophila melanogaster genome using the yeast FRT-FLP recombination system and I-SceI restriction. Achievement of the goal was solved by setting three tasks: 1) Chromosomal mapping of the inactivating gene construct p {whs pW25 dd4-exc}; 2) Genetic control of the movement of a destabilized construct containing a non-functional copy of the dd4 gene; 3) Molecular analysis of DNA of lines subjected to site-directed mutagenesis.

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OZEKI, Takeshi, Yoshiki TAKAHASHI, Toshiyuki KUME та ін. "Co-operative regulation of the transcription of human dihydrodiol dehydrogenase (DD)4/aldo–keto reductase (AKR)1C4 gene by hepatocyte nuclear factor (HNF)-4α/γ and HNF-1α". Biochemical Journal 355, № 2 (2001): 537–44. http://dx.doi.org/10.1042/bj3550537.

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Human dihydrodiol dehydrogenase (DD) 4/aldo-keto reductase (AKR) 1C4 is a major isoform of hepatic DD that oxidizes trans-dihydrodiols of polycyclic aromatic hydrocarbons to reactive and redox-active o-quinones and that reduces several ketone-containing drugs. To investigate the mechanism of transcriptional regulation of the human DD4 gene, the 5′-flanking region of the gene was fused to the luciferase gene. The results of luciferase assays using HepG2 cells and of 1,10-phenanthroline-copper footprinting indicated that two positive regulatory regions were located in regions from -701 to -684 a

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Sharipov, D. A., and S. P. Chetverikov. "STRAIN PSEUDOMONAS SP. DD4 FOR THE DESTRUCTION OF HALOGEN-CONTAINING SURFACTANTS AND HERBICIDES." ÈKOBIOTEH 4, no. 1 (2021): 60–67. http://dx.doi.org/10.31163/2618-964x-2021-4-1-60-67.

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The paper describes the properties of a strain isolated from a natural population of soil microorganisms exposed to petrochemical production, capable of destroying fluorinated surfactants and some halogenated herbicides. In the model system, the growth dynamics of the DD4 bacterial strain was studied and it was shown that the culture actively accumulates biomass when using a fluorine-containing foaming agent such as a foaming agent and active substances of the herbicides Octapon, Chistalan, and Florax as a source of carbon and energy. Based on the data obtained, the DD4 bacterial strain can be

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5

Liu, Yi, Cui Wang, Mingxia Li, et al. "Unveiling Key Genes and Crucial Pathways in Goose Muscle Satellite Cell Biology Through Integrated Transcriptomic and Metabolomic Analyses." International Journal of Molecular Sciences 26, no. 8 (2025): 3710. https://doi.org/10.3390/ijms26083710.

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Skeletal muscle satellite cells (SMSCs) are quiescent stem cells located in skeletal muscle tissue and function as the primary reservoir of myogenic progenitors for muscle growth and regeneration. However, the molecular and metabolic mechanisms governing their differentiation in geese remain largely unexplored. This study comprehensively examined the morphological, transcriptional, and metabolic dynamics of goose SMSCs across three critical differentiation stages: the quiescent stage (DD0), the differentiation stage (DD4), and the late differentiation stage (DD6). By integrating transcriptomic

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6

Kuvaeva, Elena E., Roman O. Cherezov, Dina A. Kulikova, and Ilya B. Mertsalov. "The Drosophila toothrin Gene Related to the d4 Family Genes: An Evolutionary View on Origin and Function." International Journal of Molecular Sciences 25, no. 24 (2024): 13394. https://doi.org/10.3390/ijms252413394.

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D. melanogaster has two paralogs, tth and dd4, related to the evolutionarily conserved d4 family genes. In mammals, the family consists of Dpf1-3, encoding transcription co-factors involved in the regulation of development and cell fate determination. The function of tth and dd4 in Drosophila remains unclear. The typical domain structure of the proteins encoded by the d4 family consists of an N-terminal 2/3 domain (Requiem_N), a central Kruppel-type zinc finger, and a C-terminal D4 domain of paired PHD zinc fingers (DPFs). In Drosophila, both paralogs lack the Kruppel-type ZF, and tth encodes

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7

Meteer, Jeffrey D., Dianna Koontz, Ghazia Asif, et al. "The Base Component of 3′-Azido-2′,3′-Dideoxynucleosides Influences Resistance Mutations Selected in HIV-1 Reverse Transcriptase." Antimicrobial Agents and Chemotherapy 55, no. 8 (2011): 3758–64. http://dx.doi.org/10.1128/aac.00414-11.

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ABSTRACTWe recently reported that HIV-1 resistant to 3′-azido-3′-deoxythymidine (AZT) is not cross-resistant to 3′-azido-2′,3′-dideoxypurines. This finding suggested that the nucleoside base is a major determinant of HIV-1 resistance to nucleoside analogs. To further explore this hypothesis, we conductedin vitroselection experiments by serial passage of HIV-1LAIin MT-2 cells in increasing concentrations of 3′-azido-2′,3′-dideoxyguanosine (3′-azido-ddG), 3′-azido-2′,3′-dideoxycytidine (3′-azido-ddC), or 3′-azido-2′,3′-dideoxyadenosine (3′-azido-ddA). 3′-Azido-ddG selected for virus that was 5.3

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8

Zaderikhina, Elena, Volodimir Rossokha, G. Tur, Yelyzaveta Oliinychenko, and O. Brovko. "THE GENE POOL OF THE TRAKEHNER HORSE BREED OF DOMESTIC SELECTION." Scientific and Technical Bulletin of the Institute of Animal Science NAAS of Ukraine, no. 127 (2022): 79–89. http://dx.doi.org/10.32900/2312-8402-2022-127-79-89.

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The article outlines the data on the study of the specifics of the gene pool of the horses of the Trakehner breed of domestic selection as a whole (n = 236), and leading tribal business entities and the private sector. Immunogenetic differences are identified and a comparative characteristic of horses of farms behind frequencies and spectrum of alleles of genetic blood group systems has been carried out. The population of the Trakehner breed of horses of domestic selection owns a peculiar immunogenetic profile in the context of the tribal business entities and the private sector, owns certain

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9

Kroiss, Matthias, Dietmar Plonné, Sabine Kendl, et al. "Association of mitotane with chylomicrons and serum lipoproteins: practical implications for treatment of adrenocortical carcinoma." European Journal of Endocrinology 174, no. 3 (2016): 343–53. http://dx.doi.org/10.1530/eje-15-0946.

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ObjectiveOral mitotane (o,p′-DDD) is a cornerstone of medical treatment for adrenocortical carcinoma (ACC). AimSerum mitotane concentrations >14 mg/l are targeted for improved efficacy but not achieved in about half of patients. Here we aimed at a better understanding of intestinal absorption and lipoprotein association of mitotane and metabolites o,p′-dichlorodiphenylacetic acid (o,p′-DDA) and o,p′-dichlorodiphenyldichloroethane (o,p′-DDE).DesignLipoproteins were isolated by ultracentrifugation from the chyle of a 29-year-old patient and serum from additional 14 ACC patients treated with m

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10

Gu, Zhengxian, Hengsheng Fang, Horacio Salomon, Qing Gao, and Mark A. Wainberg. "Identification of Mutations that Encode Drug Resistance in the Polymerase Gene of the Human Immunodeficiency Virus." Canadian Journal of Infectious Diseases 5, suppl e (1994): 29E—33E. http://dx.doi.org/10.1155/1994/826340.

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In vitro selection in MT-4 cells was used to generate human immunodeficiency virus-type 1 (HIV 1) variants that are resistant to 2',3'-dideoxycytidine (ddC), 2',3'-didcoxyinosine (ddI) and the (-) enantiomer of 2' ,3'-dideoxy-3'-thiacytidine (3TC). The complete reverse transcriptase open reading frames of these viruses, and portions of flanking protease and integrase within the pol gene, were cloned and sequenced by polymerase chain reaction (PCR) techniques. Mulalions were observed at each of amino acid sites 65 (Lys → Arg: AAA → AGA) and 184 (Met → Val: ATG → GTG) when ddC was used in this p

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11

Gianesello, Lisa, Monica Ceol, Loris Bertoldi, et al. "Genetic Analyses in Dent Disease and Characterization of CLCN5 Mutations in Kidney Biopsies." International Journal of Molecular Sciences 21, no. 2 (2020): 516. http://dx.doi.org/10.3390/ijms21020516.

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Dent disease (DD), an X-linked renal tubulopathy, is mainly caused by loss-of-function mutations in CLCN5 (DD1) and OCRL genes. CLCN5 encodes the ClC-5 antiporter that in proximal tubules (PT) participates in the receptor-mediated endocytosis of low molecular weight proteins. Few studies have analyzed the PT expression of ClC-5 and of megalin and cubilin receptors in DD1 kidney biopsies. About 25% of DD cases lack mutations in either CLCN5 or OCRL genes (DD3), and no other disease genes have been discovered so far. Sanger sequencing was used for CLCN5 gene analysis in 158 unrelated males clini

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12

Yvon-Groussin, Anne, Pierre Mugnier, Philippe Bertin, et al. "Efficacy of Dideoxynucleosides against Human Foamy Virus and Relationship to Its Reverse Transcriptase Amino Acid Sequence and Structure." Journal of Virology 75, no. 15 (2001): 7184–87. http://dx.doi.org/10.1128/jvi.75.15.7184-7187.2001.

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ABSTRACT Human foamy virus (HFV), a retrovirus of simian origin which occasionally infects humans, is the basis of retroviral vectors in development for gene therapy. Clinical considerations of how to treat patients developing an uncontrolled infection by either HFV or HFV-based vectors need to be raised. We determined the susceptibility of the HFV to dideoxynucleosides and found that only zidovudine was equally efficient against the replication of human immunodeficiency virus type 1 (HIV-1) and HFV. By contrast, zalcitabine (ddC), lamivudine (3TC), stavudine (d4T), and didanosine (ddI) were 3

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13

Salomon, H., Z. Gu, Q. Gao, K. Nagai, J. Hiscott, and M. A. Wainberg. "Host Cell Dependence of Human Immunodeficiency Virus Type-1 Drug Resistance Profiles and Tissue Culture Selection Patterns." Antiviral Chemistry and Chemotherapy 6, no. 4 (1995): 222–29. http://dx.doi.org/10.1177/095632029500600404.

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Clinical isolates of the human immunodeficiency virus type 1 (HIV-1) displayed differential sensitivity to antiviral nucleosides depending on the type of host cell employed for viral propagation. Viruses derived from the peripheral blood mononuclear cells (PBMC) of subjects on prolonged 3′-azido-3′-deoxythymidine (AZT) therapy behaved as AZT-resistant when tested in either cord blood mononuclear cells or MT-4 cells but as relatively drug-sensitive in the U-937 monocytic cell line. Viruses derived from monocytes/ macrophages of the same individuals behaved as drug-sensitive in all cells tested.

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14

Yin, Bao Ying, Yong Zhang, Jian Hong Sun, Ji Xia Li, and Ye Fei Ma. "Connexin37 mRNA expression in in vivo and in vitro mouse oocyte." Zygote 17, no. 2 (2009): 163–68. http://dx.doi.org/10.1017/s0967199408005170.

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SummaryTo evaluate gene expression of Connexin37 (Cx37) in oocytes from in vitro follicles at different stages, mouse preantral follicles were isolated and cultured for 12 days in vitro. Compared with in vitro follicles, follicles grown in vivo were collected at day 14 (d14), d16, d18, d20, d22 and d24 with the same stages for gene expression of Cx37 in oocytes. Our results showed that Cx37 mRNA increased along with follicular development, reached the highest level at the onset of antrum cavity formation and decreased after antrum formation in both in vivo and in vitro mouse oocytes. However,

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15

Moeller, Timothy. "Human Hepatocytes in HTS DDI Studies." Genetic Engineering & Biotechnology News 31, no. 10 (2011): 22–23. http://dx.doi.org/10.1089/gen.31.10.10.

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16

Hodgetts, Ross B., Millan S. Patel, Jana Piorecky, Andrew D. Swan, and Charlotte A. Spencer. "Identification of a sequence motif upstream of the Drosophila Dopa decarboxylase gene that enhances heterologous gene expression." Genome 37, no. 4 (1994): 526–34. http://dx.doi.org/10.1139/g94-075.

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In this paper we have examined the role that element S, a DNA sequence motif found approximately 215 bp upstream of the Dopa decarboxylase (Ddc) gene, might play in regulating Ddc expression. Nearly identical versions of the element are present upstream of four other Drosophila genes. For two of these, the element appears to be an important component of the upstream regulatory region, since mutations in it reduce expression of the downstream gene. Because an element S polymorphism differentiates the Ddc+ allele of an inbred laboratory strain from the Ddc+4 allele present in a strain isolated f

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17

Aquino-Nunez, Wendy, Zachery E. Mielko, Trae Dunn, et al. "cnd-1/NeuroD1 Functions with the Homeobox Gene ceh-5/Vax2 and Hox Gene ceh-13/labial To Specify Aspects of RME and DD Neuron Fate in Caenorhabditis elegans." G3 Genes|Genomes|Genetics 10, no. 9 (2020): 3071–85. http://dx.doi.org/10.1534/g3.120.401515.

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Abstract Identifying the mechanisms behind neuronal fate specification are key to understanding normal neural development in addition to neurodevelopmental disorders such as autism and schizophrenia. In vivo cell fate specification is difficult to study in vertebrates. However, the nematode Caenorhabditis elegans, with its invariant cell lineage and simple nervous system of 302 neurons, is an ideal organism to explore the earliest stages of neural development. We used a comparative transcriptome approach to examine the role of cnd-1/NeuroD1 in C. elegans nervous system development and function

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Jiang, Lubin, María José López-Barragán, Hongying Jiang, et al. "Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion." Proceedings of the National Academy of Sciences 107, no. 5 (2010): 2224–29. http://dx.doi.org/10.1073/pnas.0913396107.

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Plasmodium falciparum can invade erythrocytes by redundant receptors, some of which have variable expression. A P. falciparum clone Dd2 requiring erythrocyte sialic acid for invasion can be switched to a sialic acid-independent progeny clone Dd2NM by growing the Dd2 clone with neuraminidase-treated erythrocytes. The RH4 gene is transcriptionally up-regulated in Dd2NM compared to Dd2, despite the absence of DNA changes in and around the gene. We determined the epigenetic modifications around the transcription start site (TSS) at the time of expression of RH4 in Dd2NM (44 h) and at an earlier ti

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Harsanyi, Stefan, Radoslav Zamborsky, Lubica Krajciova, Milan Kokavec, and Lubos Danisovic. "Genetic Study of IL6, GDF5 and PAPPA2 in Association with Developmental Dysplasia of the Hip." Genes 12, no. 7 (2021): 986. http://dx.doi.org/10.3390/genes12070986.

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Background: Developmental dysplasia of the hip (DDH) is one of the most prevalent skeletal disorders. DDH is considered a pathologic condition with polygenic background, but environmental and mechanic factors significantly contribute to its multifactorial etiology. Inheritance consistent with autosomal dominant type has also been observed. Single-nucleotide polymorphisms (SNPs) in various genes mostly related to formation of connective tissue are studied for a possible association with DDH. Methods: We genotyped three SNPs, rs1800796 located in the promoter region of the IL6 gene, rs143383 loc

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Klann, Patrick Julian, Xiaoyan Wang, Anna Elfert, et al. "Seroprevalence of Binding and Neutralizing Antibodies Against 39 Human Adenovirus Types in Patients with Neuromuscular Disorders." Viruses 15, no. 1 (2022): 79. http://dx.doi.org/10.3390/v15010079.

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High pre-existing antibodies against viral vectors reduce their functionality and may lead to adverse complications. To circumvent this problem in future gene therapy approaches, we tested the seroprevalence of a large range of human adenovirus types in patients with neuromuscular disorders (NMDs) to find appropriate viral vector candidates for gene replacement therapy for NMDs. Binding and neutralizing antibodies against 39 human adenovirus types were tested in the sera of 133 patients with NMDs and 76 healthy controls aged 17–92 years. The influence of age, sex, and NMDs on antibody levels w

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Shen, J., and J. Hirsh. "cis-regulatory sequences responsible for alternative splicing of the Drosophila dopa decarboxylase gene." Molecular and Cellular Biology 14, no. 11 (1994): 7385–93. http://dx.doi.org/10.1128/mcb.14.11.7385-7393.1994.

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The Drosophila dopa decarboxylase gene, Ddc, is expressed in the hypoderm and in specific sets of cells in the central nervous system (CNS). The unique Ddc primary transcript is alternatively spliced in these two tissues. The Ddc CNS mRNA contains all four exons (A through D), whereas the hypodermal mRNA contains only three exons (A, C, and D). To localize cis-regulatory sequences responsible for Ddc alternative splicing, a Ddc minigene and several fusion genes containing various amounts of Ddc sequences fused to fushi tarazu (ftz) exon 1 were constructed and introduced into flies by P-element

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Shen, J., and J. Hirsh. "cis-regulatory sequences responsible for alternative splicing of the Drosophila dopa decarboxylase gene." Molecular and Cellular Biology 14, no. 11 (1994): 7385–93. http://dx.doi.org/10.1128/mcb.14.11.7385.

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The Drosophila dopa decarboxylase gene, Ddc, is expressed in the hypoderm and in specific sets of cells in the central nervous system (CNS). The unique Ddc primary transcript is alternatively spliced in these two tissues. The Ddc CNS mRNA contains all four exons (A through D), whereas the hypodermal mRNA contains only three exons (A, C, and D). To localize cis-regulatory sequences responsible for Ddc alternative splicing, a Ddc minigene and several fusion genes containing various amounts of Ddc sequences fused to fushi tarazu (ftz) exon 1 were constructed and introduced into flies by P-element

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23

Eveleth, David D., and J. Lawrence Marsh. "EVIDENCE FOR EVOLUTIONARY DUPLICATION OF GENES IN THE DOPA DECARBOXYLASE REGION OF DROSOPHILA." Genetics 114, no. 2 (1986): 469–83. http://dx.doi.org/10.1093/genetics/114.2.469.

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ABSTRACT The region surrounding the dopa decarboxylase gene (Ddc) of Drosophila contains a cluster of genes, many of which appear to be functionally related by virtue of their effects on cuticle development and/or catecholamine metabolism. In this report we describe evidence that the Ddc gene and the closely linked alpha-methyldopa hypersensitive (amd) gene share extensive sequence homology and are the products of a gene duplication event. The two genes are transcribed convergently and are separated by 2.4 kb. A gene located between Ddc and amd expresses a 2.0-kb mRNA and appears to partially

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Shin, S., K. Matsumoto, T. Amano, K. Saeki, Y. Hosoi, and A. Iritani. "281 EXPRESSION PROFILE AND KNOCKDOWN ANALYSIS OF A FUNCTIONALLY UNKNOWN DD2-2 GENE IN MOUSE PRE-IMPLANTATION EMBRYOS." Reproduction, Fertility and Development 19, no. 1 (2007): 256. http://dx.doi.org/10.1071/rdv19n1ab281.

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Zygotic gene activation (ZGA) starts at the G2 phase at the 1-cell stage in the mouse. However, the molecular mechanism of ZGA has not been completely elucidated. We have investigated the molecular functions of many gene clusters, DD clones obtained by differential display assays for ovulated eggs at the M II stage and 1-cell stage embryos at the G2 phase. As a result, we have identified a functionally unknown gene, whose sequence did not match a known transcript in the gene bank DD2-2 gene. Here, we report the expression profile and knockdown analysis of the DD2-2 gene in mouse pre-implantati

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Mura-Escorche, Glorián, Ana Perdomo-Ramírez, Elena Ramos-Trujillo, Carmen Jane Trujillo-Frías, and Félix Claverie-Martín. "Characterization of pre-mRNA Splicing Defects Caused by CLCN5 and OCRL Mutations and Identification of Novel Variants Associated with Dent Disease." Biomedicines 11, no. 11 (2023): 3082. http://dx.doi.org/10.3390/biomedicines11113082.

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Dent disease (DD) is an X-linked renal tubulopathy characterized by low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis and progressive renal failure. Two-thirds of cases are associated with inactivating variants in the CLCN5 gene (Dent disease 1, DD1) and a few present variants in the OCRL gene (Dent disease 2, DD2). The aim of the present study was to test the effect on the pre-mRNA splicing process of DD variants, described here or in the literature, and describe the clinical and genotypic features of thirteen unrelated patients with suspected DD. All patient

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Fuquan, Zhao, Seesregdorj Surenjid, Bilegtsaikhan Tsolmon, et al. "Dehydrocostus Lactone Down - regulates Lipopolysaccharide-induced SAA3 gene activation in the Microglia." Central Asian Journal of Medical Sciences 9, no. 4 (2023): 195–200. http://dx.doi.org/10.24079/cajms.2023.12.006.

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Running Title: DDL inhibits the LPS-induced SAA3 gene expression in microgliaObjective: Research on the mechanism of Dehydrocostus lactone (DDL) in microglial cells of the brain needs to be improved, despite its reported anti-inflammatory, anticancer, and anti-proliferation properties as a natural product of Eerdun Wurile The precise functions of the Serum amyloid A (SAA) genes are not yet defined. However, these genes are suggested to possess antibacterial properties and can attract monocytes and neutrophils. On the other hand, SAA genes can also induce inflammatory cytokines and metalloprote

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Menheniott, Trevelyan R., Kathryn Woodfine, Reiner Schulz, et al. "Genomic Imprinting of Dopa decarboxylase in Heart and Reciprocal Allelic Expression with Neighboring Grb10." Molecular and Cellular Biology 28, no. 1 (2007): 386–96. http://dx.doi.org/10.1128/mcb.00862-07.

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ABSTRACT By combining a tissue-specific microarray screen with mouse uniparental duplications, we have identified a novel imprinted gene, Dopa decarboxylase (Ddc), on chromosome 11. Ddc_exon1a is a 2-kb transcript variant that initiates from an alternative first exon in intron 1 of the canonical Ddc transcript and is paternally expressed in trabecular cardiomyocytes of the embryonic and neonatal heart. Ddc displays tight conserved linkage with the maternally expressed and methylated Grb10 gene, suggesting that these reciprocally imprinted genes may be coordinately regulated. In Dnmt3L mutant e

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Shen, J., C. J. Beall, and J. Hirsh. "Tissue-specific alternative splicing of the Drosophila dopa decarboxylase gene is affected by heat shock." Molecular and Cellular Biology 13, no. 8 (1993): 4549–55. http://dx.doi.org/10.1128/mcb.13.8.4549-4555.1993.

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The Drosophila dopa decarboxylase gene, Ddc, is expressed in the hypoderm and in a small number of cells in the central nervous system (CNS). The unique Ddc primary transcript is alternatively spliced in these two tissues. We investigated whether Ddc splicing in the CNS is a general property of the CNS or a unique property of the cells that normally express Ddc by expressing the Ddc primary transcript ubiquitously under the control of an Hsp70 heat shock promoter. Under basal expression conditions, Ddc splicing shows normal tissue specificity, indicating that the regulation of Ddc splicing in

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Shen, J., C. J. Beall, and J. Hirsh. "Tissue-specific alternative splicing of the Drosophila dopa decarboxylase gene is affected by heat shock." Molecular and Cellular Biology 13, no. 8 (1993): 4549–55. http://dx.doi.org/10.1128/mcb.13.8.4549.

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The Drosophila dopa decarboxylase gene, Ddc, is expressed in the hypoderm and in a small number of cells in the central nervous system (CNS). The unique Ddc primary transcript is alternatively spliced in these two tissues. We investigated whether Ddc splicing in the CNS is a general property of the CNS or a unique property of the cells that normally express Ddc by expressing the Ddc primary transcript ubiquitously under the control of an Hsp70 heat shock promoter. Under basal expression conditions, Ddc splicing shows normal tissue specificity, indicating that the regulation of Ddc splicing in

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Jin, Hong, Elaine Kendall, Tom C. Freeman, Roland G. Roberts, and David L. P. Vetrie. "The Human Family of Deafness/Dystonia Peptide (DDP) Related Mitochondrial Import Proteins." Genomics 61, no. 3 (1999): 259–67. http://dx.doi.org/10.1006/geno.1999.5966.

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Mpekoulis, George, Efseveia Frakolaki, Styliani Taka, et al. "Alteration of L-Dopa decarboxylase expression in SARS-CoV-2 infection and its association with the interferon-inducible ACE2 isoform." PLOS ONE 16, no. 6 (2021): e0253458. http://dx.doi.org/10.1371/journal.pone.0253458.

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L-Dopa decarboxylase (DDC) is the most significantly co-expressed gene with ACE2, which encodes for the SARS-CoV-2 receptor angiotensin-converting enzyme 2 and the interferon-inducible truncated isoform dACE2. Our group previously showed the importance of DDC in viral infections. We hereby aimed to investigate DDC expression in COVID-19 patients and cultured SARS-CoV-2-infected cells, also in association with ACE2 and dACE2. We concurrently evaluated the expression of the viral infection- and interferon-stimulated gene ISG56 and the immune-modulatory, hypoxia-regulated gene EPO. Viral load and

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Hao, Jiali, Wenjie Xie, Hui Li, and Runsheng Li. "Prostate Cancer-Specific of DD3-driven oncolytic virus-harboring mK5 gene." Open Medicine 14, no. 1 (2018): 1–9. http://dx.doi.org/10.1515/med-2019-0001.

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AbstractProstate cancer (PCa) is the second most diagnosed cancer in Western male population. In this study, we insert mK5 (the mutational kringle5 of human plasminogen) into a DD3-promoted (differential display code 3) oncolytic adenovirus to construct OncoAd.mK5.DD3. E1A.dE1B, briefly, OAd.DD3.mK5. DD3 is one of the most prostate cancer specific promoters which can transcriptionally control adenoviral replication. mK5 has been proved to be able to inhibit the tumor angiogenesis and inhibit cell proliferation. Our results suggested that targeting PCa with OAd.DD3.mK5 elicited strong antitumor

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Davis, Monica M., David A. Primrose, and Ross B. Hodgetts. "A Member of the p38 Mitogen-Activated Protein Kinase Family Is Responsible for Transcriptional Induction of Dopa decarboxylase in the Epidermis of Drosophila melanogaster during the Innate Immune Response." Molecular and Cellular Biology 28, no. 15 (2008): 4883–95. http://dx.doi.org/10.1128/mcb.02074-07.

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ABSTRACT Drosophila innate immunity is controlled primarily by the activation of IMD (immune deficiency) or Toll signaling leading to the production of antimicrobial peptides (AMPs). IMD signaling also activates the JUN N-terminal kinase (JNK) cascade, which is responsible for immune induction of non-antimicrobial peptide immune gene transcription though the transcription factor AP-1. Transcription of the Dopa decarboxylase (Ddc) gene is induced in response to gram-negative and gram-positive septic injury, but not aseptic wounding. Transcription is induced throughout the epidermis and not spec

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Mori, Yu, Kazuko Ueno, Daisuke Chiba, et al. "Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway." International Journal of Molecular Sciences 24, no. 5 (2023): 5019. http://dx.doi.org/10.3390/ijms24055019.

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This study examined the association between developmental dysplasia of the hip (DDH) and disease-associated loci in a Japanese cohort. A genome-wide association study (GWAS) of 238 Japanese patients with DDH and 2044 healthy individuals was performed. As a replicate, GWAS was also conducted on the UK Biobank data with 3315 cases and matched 74,038 controls. Gene set enrichment analyses (GSEAs) of both the genetics and transcriptome of DDH were performed. Transcriptome analysis of cartilage specimens from DDH-associated osteoarthritis and femoral neck fractures was performed as a control. Most

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Mastick, G. S., and S. B. Scholnick. "Repression and activation of the Drosophila dopa decarboxylase gene in glia." Molecular and Cellular Biology 12, no. 12 (1992): 5659–66. http://dx.doi.org/10.1128/mcb.12.12.5659-5666.1992.

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Glial expression of the Drosophila dopa decarboxylase gene (Ddc) is repressed by a regulatory region located approximately 1 kb upstream of the transcriptional start site. We have used in vitro mutagenesis and germ line transformation to determine which elements within the Ddc promoter mediate repression. Our evidence suggests that the hypodermal cell activator elements IIA and IIB play a major role in the transcriptional regulation of Ddc in glial cells. A variety of mutations demonstrate that element IIA is a strong glial activator element and that element IIB is necessary for glial repressi

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Mastick, G. S., and S. B. Scholnick. "Repression and activation of the Drosophila dopa decarboxylase gene in glia." Molecular and Cellular Biology 12, no. 12 (1992): 5659–66. http://dx.doi.org/10.1128/mcb.12.12.5659.

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Glial expression of the Drosophila dopa decarboxylase gene (Ddc) is repressed by a regulatory region located approximately 1 kb upstream of the transcriptional start site. We have used in vitro mutagenesis and germ line transformation to determine which elements within the Ddc promoter mediate repression. Our evidence suggests that the hypodermal cell activator elements IIA and IIB play a major role in the transcriptional regulation of Ddc in glial cells. A variety of mutations demonstrate that element IIA is a strong glial activator element and that element IIB is necessary for glial repressi

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Gailey, Donald A., Deborah L. Bordne, Ana Maria Vallés, Jeffrey C. Hall, and Kalpana White. "Construction of an Unstable Ring-X Chromosome Bearing the Autosomal Dopa Decarboxylase Gene in Drosophila melanogaster and Analysis of Ddc Mosaics." Genetics 115, no. 2 (1987): 305–11. http://dx.doi.org/10.1093/genetics/115.2.305.

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ABSTRACT An unstable Ring-X chromosome, Ddc +- Ring-X carrying a cloned Dopa decarboxylase (Ddc) encoding segment was constructed. The construction involved a double recombination event between the unstable Ring-X, R(1)wvC and a Rod-X chromosome which contained a P-element mediated Ddc + insert. The resulting Ddc +-Ring-X chromosome behaves similarly to the parent chromosome with respect to somatic instability. The Ddc +-Ring-X chromosome was used to generate Ddc mosaics. Analyses of Ddc mosaics revealed that while there was no absolute requirement for the Ddc + expression in either the epider

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Hirsh, J., B. A. Morgan, and S. B. Scholnick. "Delimiting regulatory sequences of the Drosophila melanogaster Ddc gene." Molecular and Cellular Biology 6, no. 12 (1986): 4548–57. http://dx.doi.org/10.1128/mcb.6.12.4548-4557.1986.

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We delimited sequences necessary for in vivo expression of the Drosophila melanogaster dopa decarboxylase gene Ddc. The expression of in vitro-altered genes was assayed following germ line integration via P-element vectors. Sequences between -209 and -24 were necessary for normally regulated expression, although genes lacking these sequences could be expressed at 10 to 50% of wild-type levels at specific developmental times. These genes showed components of normal developmental expression, which suggests that they retain some regulatory elements. All Ddc genes lacking the normal immediate 5'-f

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Hirsh, J., B. A. Morgan, and S. B. Scholnick. "Delimiting regulatory sequences of the Drosophila melanogaster Ddc gene." Molecular and Cellular Biology 6, no. 12 (1986): 4548–57. http://dx.doi.org/10.1128/mcb.6.12.4548.

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We delimited sequences necessary for in vivo expression of the Drosophila melanogaster dopa decarboxylase gene Ddc. The expression of in vitro-altered genes was assayed following germ line integration via P-element vectors. Sequences between -209 and -24 were necessary for normally regulated expression, although genes lacking these sequences could be expressed at 10 to 50% of wild-type levels at specific developmental times. These genes showed components of normal developmental expression, which suggests that they retain some regulatory elements. All Ddc genes lacking the normal immediate 5'-f

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Kartheeswaran, Karpaga Priyaa, Arockia Xavier Annie Rayan, and Geetha Thekkumpurath Varrieth. "Enhanced disease-disease association with information enriched disease representation." Mathematical Biosciences and Engineering 20, no. 5 (2023): 8892–932. http://dx.doi.org/10.3934/mbe.2023391.

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<abstract> <sec><title>Objective</title><p>Quantification of disease-disease association (DDA) enables the understanding of disease relationships for discovering disease progression and finding comorbidity. For effective DDA strength calculation, there is a need to address the main challenge of integration of various biomedical aspects of DDA is to obtain an information rich disease representation. Materials and</p> </sec> <sec><title>Methods</title><p>An enhanced and integrated DDA framework is developed that integrates enriche

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Clave, Emmanuel, Itauá Leston Araujo, Cécile Alanio, et al. "Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus." Science Translational Medicine 10, no. 457 (2018): eaao2966. http://dx.doi.org/10.1126/scitranslmed.aao2966.

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The thymus is the primary lymphoid organ where naïve T cells are generated; however, with the exception of age, the parameters that govern its function in healthy humans remain unknown. We characterized the variability of thymic function among 1000 age- and sex-stratified healthy adults of the Milieu Intérieur cohort, using quantification of T cell receptor excision circles (TRECs) in peripheral blood T cells as a surrogate marker of thymopoiesis. Age and sex were the only nonheritable factors identified that affect thymic function. TREC amounts decreased with age and were higher in women comp

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Harsanyi, Stefan, Radoslav Zamborsky, Lubica Krajciova, Milan Kokavec, and Lubos Danisovic. "Developmental Dysplasia of the Hip: A Review of Etiopathogenesis, Risk Factors, and Genetic Aspects." Medicina 56, no. 4 (2020): 153. http://dx.doi.org/10.3390/medicina56040153.

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As one of the most frequent skeletal anomalies, developmental dysplasia of the hip (DDH) is characterized by a considerable range of pathology, from minor laxity of ligaments in the hip joint to complete luxation. Multifactorial etiology, of which the candidate genes have been studied the most, poses a challenge in understanding this disorder. Candidate gene association studies (CGASs) along with genome-wide association studies (GWASs) and genome-wide linkage analyses (GWLAs) have found numerous genes and loci with susceptible DDH association. Studies put major importance on candidate genes as

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Ahmed, Aisha, Svante Berg, Kanar Alkass та ін. "NF-κB-Associated Pain-Related Neuropeptide Expression in Patients with Degenerative Disc Disease". International Journal of Molecular Sciences 20, № 3 (2019): 658. http://dx.doi.org/10.3390/ijms20030658.

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The role of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) has been highlighted in mechanisms underlying inflammatory and neuropathic pain processes. The present study was designed to investigate whether NF-κB signaling is associated with pain-related neuropeptide expression in patients with chronic back pain related to degenerative disc disease (DDD). Intervertebral disc (IVD) tissues were collected from forty DDD patients undergoing disc replacement or fusion surgery, and from eighteen postmortem (PM) control subjects. RELA, NFKB1, CGRP, TAC1, TRPV1, and MMP-3 gene ex

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Zhang, Jian, Yuchao Ma, and Huimin Yu. "Nocardioides lianchengensis sp. nov., an actinomycete isolated from soil." International Journal of Systematic and Evolutionary Microbiology 62, Pt_11 (2012): 2698–702. http://dx.doi.org/10.1099/ijs.0.036723-0.

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A novel Gram-stain-positive, aerobic, rod-shaped bacterium, designated strain D94-1T, was isolated from soil collected in Liancheng county, Fujian province, PR China. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain D94-1T was a member of the genus Nocardioides and was most closely related to Nocardioides salarius DSM 18239T (98.54 % 16S rRNA gene sequence similarity), Nocardioides marinisabuli DSM 18965T (98.30 %), Nocardioides basaltis KCTC 19365T (98.10 %) and Nocardioides dokdonensis KCTC 19309T (97.76 %). Phenotypic characteristics and DNA–DNA relatedness data s

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Eisenberg, Daniel P., Philip D. Kohn, Catherine E. Hegarty, et al. "Common Variation in the DOPA Decarboxylase (DDC) Gene and Human Striatal DDC Activity In Vivo." Neuropsychopharmacology 41, no. 9 (2016): 2303–8. http://dx.doi.org/10.1038/npp.2016.31.

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Harsanyi, Stefan, Radoslav Zamborsky, Lubica Krajciova, Daniel Bohmer, Milan Kokavec, and Lubos Danisovic. "Association Analysis of GDF5 and Contributing Factors in Developmental Dysplasia of the Hip in Infants." Ortopedia Traumatologia Rehabilitacja 23, no. 5 (2021): 335–39. http://dx.doi.org/10.5604/01.3001.0015.4348.

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Background. Developmental dysplasia of the hip (DDH) is a developmental disorder which is reported to be associated with hip instability. When untreated, it can lead to irreversible joint damage. DDH is known to be a multifactorial disease involving genetic, mechanical and environmental factors. The greatest causative potential is attributed to the genetic component. Growth Differentiation Factor 5 (GDF5) is among the most studied genes associated with processes of regeneration and maintenance of joints. The aim of this work was to analyse the association of SNP rs143383 in the GDF5 gene and t

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Milewski, W. M., S. Boyle-Vavra, B. Moreira, C. C. Ebert, and R. S. Daum. "Overproduction of a 37-kilodalton cytoplasmic protein homologous to NAD+-linked D-lactate dehydrogenase associated with vancomycin resistance in Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 40, no. 1 (1996): 166–72. http://dx.doi.org/10.1128/aac.40.1.166.

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We previously reported the isolation of a laboratory-derived Staphylococcus aureus mutant, 523k, that has constitutive low-level resistance to vancomycin (MIC = 5 micrograms/ml) and teicoplanin (MIC = 5 micrograms/ml) and elaborates a ca. 39-kDa cytoplasmic protein that was not detected in the parent strain 523 (MIC = 1 micrograms/ml). We have now detected the protein in strain 523 by immunoblotting with antiserum raised against the protein. Consistent with our initial observations, densitometric analysis of the immunoblots revealed an increased production of the protein in 523k compared with

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Davis, Monica M., Ping Yang, Liam Chen, Sandra L. O’Keefe, and Ross B. Hodgetts. "The orphan nuclear receptor DHR38 influences transcription of the DOPA decarboxylase gene in epidermal and neural tissues of Drosophila melanogaster." Genome 50, no. 11 (2007): 1049–60. http://dx.doi.org/10.1139/g07-084.

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The DOPA decarboxylase gene (Ddc) belongs to the “early-late” class of ecdysone-inducible genes in Drosophila melanogaster . Its expression is up-regulated in epidermal tissues by the ecdysone receptor acting through a response element, EcRE. In this paper, we show that another member of the nuclear receptor superfamily, DHR38, may act as a repressor of epidermal Ddc while inducing Ddc expression in neuronal cells. DHR38 does not behave as a classical co-repressor of the ecdysone receptor though, since the site through which DHR38 acts is distinct from the EcRE. Ectopic expression of a Dhr38 c

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Zhang, Chen, Fanhao Wang, Peng Jiao, et al. "The Overexpression of Zea mays Strigolactone Receptor Gene D14 Enhances Drought Resistance in Arabidopsis thaliana L." International Journal of Molecular Sciences 25, no. 2 (2024): 1327. http://dx.doi.org/10.3390/ijms25021327.

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Strigolactones (SLs) represent a recently identified class of plant hormones that are crucial for plant tillering and mycorrhizal symbiosis. The D14 gene, an essential receptor within the SLs signaling pathway, has been well-examined in crops, like rice (Oryza sativa L.) and Arabidopsis (Arabidopsis thaliana L.), yet the research on its influence in maize (Zea mays L.) remains scarce. This study successfully clones and establishes Arabidopsis D14 gene overexpression lines (OE lines). When compared with the wild type (WT), the OE lines exhibited significantly longer primary roots during germina

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Aquadro, C. F., R. M. Jennings, M. M. Bland, C. C. Laurie, and C. H. Langley. "Patterns of naturally occurring restriction map variation, dopa decarboxylase activity variation and linkage disequilibrium in the Ddc gene region of Drosophila melanogaster." Genetics 132, no. 2 (1992): 443–52. http://dx.doi.org/10.1093/genetics/132.2.443.

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Abstract Forty-six second-chromosome lines of Drosophila melanogaster isolated from five natural populations were surveyed for restriction map variation in a 65-kb region surrounding the gene (Ddc) encoding dopa decarboxylase (DDC). Sixty-nine restriction sites were scored, 13 of which were polymorphic. Average heterozygosity per nucleotide was estimated to be 0.005. Eight large (0.7-5.0 kb) inserts, two small inserts (100 and 200 bp) and three small deletions (100-300 bp) were also observed across the 65-kb region. We see no evidence for a reduction in either nucleotide heterozygosity or inse

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