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Dissertations / Theses on the topic 'DDAH2'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Kelly, P. D. "Elucidation of the biochemical and physiological role of DDAH2." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1317766/.

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The asymmetric methylarginines monomethyl-L-arginine (L-NMMA) and asymmetric dimethylarginine (ADMA) are endogenously occurring inhibitors of the nitric oxide synthase (NOS) enzymes. Elevated plasma ADMA has been identified in a range of human cardiovascular disorders, some of which are associated with impaired NO signaling. The dimethylarginine dimethlyaminohydrolase (DDAH) enzymes are responsible for the degradation of asymmetric methylarginines in vivo. The physiological link between DDAH, ADMA, and NOS was demonstrated by a mouse genetic knockout of DDAH1. Ddah1+/- mice had elevated ADMA c

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2

Tran, Cam Thanh Lucy. "Molecular analysis of human DDAH genes." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408021.

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3

Tommasi, Sara. "Design and synthesis of human dimethylarginine dimethylaminohydrolase (DDAH) inhibitors and development of a novel DDAH activity assay." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=227616.

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Nitric oxide (NO) is a key physiological messenger, but an excessive production of this molecule can be detrimental, leading to the onset or worsening of many pathological conditions. Dimethylarginine dimethylaminohydrolase (DDAH) is a key enzyme in the NO pathway, involved in the metabolism of asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA), which are both endogenous inhibitors of NO synthesis. Two isoforms of DDAH have been identified in humans, namely DDAH-1 and DDAH-2. DDAH inhibition represents a promising strategy in the treatment of NO overproduction under pathologic

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4

Pullamsetti, Soni. "Role of Dimethylarginine Dimethylaminohydrolases (DDAH) in pulmonary arterial hypertension." Giessen VVB Laufersweiler, 2006. http://geb.uni-giessen.de/geb/volltexte/2006/2892/index.html.

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5

Tomlinson, James. "The role of DDAH and ADMA in kidney disease." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24541.

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Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis and elevated plasma levels associate with poor cardiovascular and renal outcomes. The dimethylarginine dimethylaminohydrolase enzymes (DDAHs; 1 and 2) metabolise ADMA. A DDAH1 gene variant associates with higher kidney tissue mRNA expression, lower plasma ADMA but counter-intuitively, a steeper rate of eGFR decline. This indicates that renal DDAH1 activity may be deleterious and circulating ADMA does not necessarily reflect the NO-ADMA balance (or severity of disease) within kidney tissue. This study t

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6

Dowsett, Laura Bethany. "The role of the NOS-ADMA-DDAH1 pathway in adipocytes and obesity." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24709.

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Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS) which is metabolised by two isoforms of the enzyme dimethylarginine dimethylaminohydrolase (DDAH). Inhibition of DDAH has been shown to increase ADMA concentrations both in vitro and in vivo. Clinically, high concentrations of ADMA have been associated with a range of diseases, particularly cardiovascular disease and more recently obesity. The role of the NO-ADMA-DDAH pathway has not yet been studied in adipose tissue. This thesis sets out to investigate the effects of pathological ADMA exposure firstl

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7

Pullamsetti, Soni [Verfasser]. "Role of dimethylarginine dimethylaminohydrolases (DDAH) in pulmonary arterial hypertension / vorgelegt von Soni Pullamsetti." Giessen : VVB Laufersweiler, 2006. http://d-nb.info/98866240X/34.

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8

Khanom, N. "Evaluation of novel arginine based inhibitors of DDAH and investigations into radical hydroacylation of vinyl sulfonates." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/192842/.

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The thesis is in two main sections. In the first section, studies on methylarginine processing enzymes are presented. Dimethyalrginine dimethylaminohydrolase (DDAH) is a class of enzymes involved in the metabolism of methylarginines ADMA and L-NMMA, which indirectly regulate physiological nitric oxide levels. It is desirable to inhibit excess NO in pathological situations, and the arginine mimetic L-257 is a DDAH inhibitor which reduces levels of NO. Synthesis of ester analogues of L-257 proved to be troublesome with a low yielding key guanidine forming reaction. However, amide analogues were

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9

Sonnenberg, Derek M. "Design and Synthesis of Novel Chloroacetimidine Inactivators as Potential in vivo Activity Probes of DDAH-1 for Regulation of NOS." Thesis, Southern Illinois University at Edwardsville, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10247909.

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<p> Nitric Oxide, NO, is an important neurotransmitter and signaling molecule in almost every system of the human body. Its regulation is equally important as a dysfunction in regulation leads to pathophysiologic conditions and disease states. There are many ways that NO is regulated, but one of the more common methods is to regulate the enzyme that creates it, Nitric Oxide Synthases or NOS. Again, many ways to regulate this enzyme exist, but this work focuses on inhibition by an endogenous molecule produced via the normal process of protein degradation, Asymmetric Dimethyl Arginine or ADMA. A

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10

Bernges, Isabel [Verfasser], and Elke [Akademischer Betreuer] Oetjen. "Die Metabolisierung der Dimethylarginine durch die Enzyme AGXT2 und DDAH1 und deren Anwendung für den Prozess der Drug Discovery / Isabel Bernges. Betreuer: Elke Oetjen." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2014. http://d-nb.info/1064076769/34.

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11

Ratz, Patrick. "Synthesis of 4-[(2-chloroethanimidamido) methyl --N- (prop-2-yn-1-yl) benzamide, a possible in vivo activity probe of DDAH-like enzymes." Thesis, Southern Illinois University at Edwardsville, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1602062.

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<p> Nitric Oxide is an important molecule in human cells. It is responsible for multiple functions in various systems including the cardiovascular, immune, nervous, digestive, and reproductive systems. Nitric oxide is synthesized by the enzyme nitric oxide synthase, and its activity is controlled by the levels of asymmetric dimethyl arginine (ADMA) which in turn are controlled by Dimethylaminohydrolase (DDAH). DDAH is an important enzyme for study due to its ability to indirectly control nitric oxide synthase. 2-chloroacetimidine is an inhibitor of DDAH. Synthesizing molecules that contain a 2

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12

Gaber, Mohammed Bakr Adel [Verfasser]. "Hypoxia-dependent mechanisms in the pulmonary circulation : Role of dimethylarginine dimethylaminohydrolase 1 (DDAH-1) in acute, sustained and chronic hypoxia / Adel Gaber Mohammed Bakr." Gießen : Universitätsbibliothek, 2011. http://d-nb.info/1063109906/34.

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13

Carmann, Christina [Verfasser], Thomas [Gutachter] Lücke, and Stephan [Gutachter] Volker. "Das DDAH/ADMA/NO-System und die nitrit-abhängige renale Carbonanhydrase-Aktivität bei Kindern und Jugendlichen mit Diabetes mellitus Typ 1 / Christina Carmann ; Gutachter: Thomas Lücke, Stephan Volker ; Medizinische Fakultät." Bochum : Ruhr-Universität Bochum, 2018. http://d-nb.info/1154307794/34.

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14

Lüneburg, Nicole [Verfasser]. "Molekularbiologische Untersuchung der DDAH-Defizienz / vorgelegt von Nicole Lüneburg." 2008. http://d-nb.info/990534472/34.

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15

Stone, Everett Monroe. "The catalytic mechanism of dimethylarginine dimethylaminohydrolase (DDAH) from pseudomonas aeruginosa." Thesis, 2006. http://hdl.handle.net/2152/2934.

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16

Chen, Chien-Hui, and 陳芊卉. "The Relationship between DDH2 and Cell Growth in Oral Cancer Cells." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/92532081041934097376.

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碩士<br>國立陽明大學<br>藥理學研究所<br>93<br>DDH (dihydrodiol dehydrogenase) is a monomeric, cytosolic NADP(H) -dependent oxidoreductase, which belongs to AKR superfamily. DDH involves in some metabolisms of steroid hormones and prostaglandins and can also catalyze metabolisms of several xenobiotics. In humans, at least four isoforms of DDH have been identified and characterized, including DDH1, DDH2, DDHx, and DDH4. Previous studies have indicated that overexpression of DDH in non-small cell lung cancer and esophageal squamous cell carcinoma was positively correlated with tumor stage, local recurrence and

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17

Burstein, Gayle Diane. "An investigation of the irreversible inhibition of human N[superscript ω], N[superscript ω]- dimethylarginine dimethylaminohydrolase (DDAH1)". Thesis, 2014. http://hdl.handle.net/2152/31281.

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Nitric oxide synthases (NOS) are responsible for the production of nitric oxide (NO), an essential cell-signaling molecule, in mammals. There are three isoforms of NOS with widely different tissue distribution. The overproduction of NO is marked in many human disease states and cancers, however due to the similarities of the enzyme isoforms, targeting NOS for inhibition has proven challenging. Endogenously, the methylated arginines, N[superscript ω]-monomethyl-L-arginine (NMMA) and asymmetric N[superscript ω], N[superscript ω]-dimethyl-L-arginine (ADMA), inhibit NOS. N[superscript ω], N[supers

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18

Chobanyan, Kristine Tsikas Dimitrios. "Entwicklung, Validierung und Anwendung von GC/MS-Methoden für die Bestimmung der DDAH-Aktivität in vitro und in vivo : Evaluierung der Bedeutung von S-Nitrosothiolen als potentielle Inhibitoren der DDAH-Aktivität /." 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=017048731&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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19

Tan-Andresen, Jing [Verfasser]. "Entwicklung und Validierung eines Dimethylarginin-Dimethylaminohydrolase (DDAH)-Aktivitätsassays in Gewebehomogenat / vorgelegt von Jing Tan-Andresen." 2008. http://d-nb.info/991805550/34.

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20

Chang, Shih-Chieh, and 張仕杰. "Elucidating the effects of adenovirus-mediated DDAH on vascular endothelial and smooth muscle cells function." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/34758008288652431087.

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碩士<br>中國醫藥大學<br>醫學研究所<br>93<br>Restenosis is a major clinical problem that occurs in 30% to 50% of patients who undergo a Percutaneous Transluminal Coronary Angioplasty (PTCA) procedure and limits its long-term success. Accumulating evidence has indicated that Nitric Oxide (NO) is a major regulator of cardiovascular physiology and can reduce vascular and cardiac contractility. It is found that an endogenous inhibitors, asymmetric dimethylarginine (ADMA), may regulate NOS activity. A vascular endogenous enzyme, dimethylarginine dimethylaminohydrolase (DDAH), has been found to be the major media

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21

Chobanyan, Kristine [Verfasser]. "Entwicklung, Validierung und Anwendung von GC-MS-Methoden für die Bestimmung der DDAH-Aktivität in vitro und in vivo : Evaluierung der Bedeutung von S-Nitrosothiolen als potentielle Inhibitoren der DDAH-Aktivität / vorgelegt von Kristine Chobanyan." 2008. http://d-nb.info/990164217/34.

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22

Wang, Yun 1981. "Controlling nitric oxide (NO) overproduction : N[omega], N[omega]-dimethylarginine dimethylaminohydrolase (DDAH) as a novel drug target." 2010. http://hdl.handle.net/2152/14048.

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Nitric oxide (NO) overproduction is correlated with numerous human diseases, such as arthritis, asthma, diabetes, inflammation and septic shock. The enzyme activities of both NO synthase (NOS) and dimethylarginine dimethylaminohydrolase-1 (DDAH-1) promote NO production. DDAH-1 mainly colocalizes in the same tissues as the neuronal isoform of NOS and catabolizes the endogenously-produced competitive inhibitors of NOS, N[omega]-monomethyl-L-arginine (NMMA) and asymmetric N[omega], N[omega]-dimethyl-L-arginine (ADMA). Inhibition of DDAH-1 leads to elevated concentrations of NMMA and ADMA, which s

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23

Chen, Shu-Fan, and 陳書樊. "The biomarker for the early stage of diabetic nephropathy and microRNA miR-30c affects kidney fibrosis through regulating expression of DDAH1 and IRS1 proteins." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/z6mx6c.

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碩士<br>國立交通大學<br>生物科技學系<br>105<br>Diabetes mellitus (DM) is a chronic disease that can result in many complications in people. One majority of them is kidney disease, which may finally lead to the end-stage renal disease (ESRD). However, the precise mechanism is still unclear. Hence, the better understanding of the disease may provide us novel therapeutic targets. MicroRNA is a short non-coding RNA that plays an important role in cell growth, proliferation, differentiation and immune response. Furthermore, it also has the potential to regulate several physiological and pathological processes. W

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24

Lluis, Matthew Wayne. "Crystal structures of dimethylarginine dimethylaminohydrolase-1 (DDAH-1) from Homo sapiens bound to the inhibitors N⁵-(1-iminopentyl)-L-ornithine and ebselen and functional studies of the translin●trax complex from Mus musculus." Thesis, 2009. http://hdl.handle.net/2152/ETD-UT-2009-12-423.

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Nitric oxide (NO) is reactive, radical gas that is involved in a myriad of cellular signaling pathways including the regulation of blood flow and immunodefense. NO is produced from the oxidation of L-arginine to L-citrulline by nitric oxide synthase (NOS). The activity of NOS and by default, the production of NO, is regulated by the arginine derivatives N[omega],N[omega]-dimethyl-L-arginine (ADMA) and N[omega]-monomethyl-L-arginine (NMMA) which arise from the proteolytic degradation of post translationally methylated proteins. The cellular concentrations of ADMA and NMMA are regulated by th

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