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Journal articles on the topic 'DDMGD'

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1

Raies, Arwa Bin, Hicham Mansour, Roberto Incitti, and Vladimir B. Bajic. "DDMGD: the database of text-mined associations between genes methylated in diseases from different species." Nucleic Acids Research 43, no. D1 (2014): D879—D886. http://dx.doi.org/10.1093/nar/gku1168.

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2

Eiras-Diaz, Aldara, Francesco Prisco, Orlando Paciello, et al. "Unusual clinical presentation of dystrophin-deficient feline muscular dystrophy in the UK." Veterinary Record Case Reports 8, no. 1 (2020): e000983. http://dx.doi.org/10.1136/vetreccr-2019-000983.

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An eight-month-old, male, neutered, domestic short hair cat was presented for further investigation of white granuloma-like lesions on the tongue and recent onset regurgitation. The owner reported that the cat had an ‘unusual’ gait. Moderate increases in alanine aminotransferase, aspartate aminostransferase and markedly elevated creatine kinase were present. Thoracic radiographs revealed moderate-to-severe oesophageal impaction, cardiomegaly and an irregular appearance of the diaphragm. Endoscopy revealed a distended oesophagus with accumulation of ingesta. Difficulties were encountered when p
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3

Lin, Duo, Ren Yong, Xu Boyu, and Yang Xin. "Magnetic resonance imaging reconstruction based on geometric distillation and feature adaptation." Journal of Applied Artificial Intelligence 1, no. 2 (2024): 157–67. http://dx.doi.org/10.59782/aai.v1i2.298.

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Although existing deep learning-based compressed sensing magnetic resonance imaging methods have achieved good results, the interpretability of these methods is still challenging, and the transition from theoretical analysis to network design is not natural enough. To solve the above problems, this paper proposes a deep dual-domain geometry distillation feature adaptive network (DDGD-FANet). The deep unfolded network iteratively unfolds the magnetic resonance imaging reconstruction optimization problem into three sub-parts: data consistency module, dual-domain geometry distillation module and
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4

Beckers, Evy, Ine Cornelis, Sofie F. M. Bhatti, et al. "A Nonsense Variant in the DMD Gene Causes X-Linked Muscular Dystrophy in the Maine Coon Cat." Animals 12, no. 21 (2022): 2928. http://dx.doi.org/10.3390/ani12212928.

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(1) Feline dystrophin-deficient muscular dystrophy (ddMD) is a fatal disease characterized by progressive weakness and degeneration of skeletal muscles and is caused by variants in the DMD gene. To date, only two feline causal variants have been identified. This study reports two cases of male Maine coon siblings that presented with muscular hypertrophy, growth retardation, weight loss, and vomiting. (2) Both cats were clinically examined and histopathology and immunofluorescent staining of the affected muscle was performed. DMD mRNA was sequenced to identify putative causal variants. (3) Both
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5

Lu, Jing, and Walter F. Boron. "Reversible and irreversible interactions of DIDS with the human electrogenic Na/HCO3 cotransporter NBCe1-A: role of lysines in the KKMIK motif of TM5." American Journal of Physiology-Cell Physiology 292, no. 5 (2007): C1787—C1798. http://dx.doi.org/10.1152/ajpcell.00267.2006.

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Others have shown that H2DIDS reversibly and covalently binds to the first lysine (K) in the SKLIK motif at the extracellular end of transmembrane segment 5 of the Cl-HCO3 exchanger AE1. Here we mutated K558, K559, and/or K562 in the homologous KKMIK motif of human NBCe1-A. We expressed constructs in Xenopus oocytes, and used a two-electrode voltage clamp to test the sensitivity of the NBC current (−160 to +20 mV) to DIDS. A 30-s DIDS exposure decreased the current at 0 mV, and a subsequent albumin wash returned the current to the initial value (less any irreversible DIDS inhibition), permitti
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6

Gambino, Anya N., Pamela J. Mouser, G. Diane Shelton, and Nena J. Winand. "Emergent Presentation of a Cat with Dystrophin-Deficient Muscular Dystrophy." Journal of the American Animal Hospital Association 50, no. 2 (2014): 130–35. http://dx.doi.org/10.5326/jaaha-ms-5973.

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This report describes a case of feline dystrophin-deficient muscular dystrophy (DDMD) with an atypical clinical presentation. A novel gene mutation is reported to be responsible for dystrophin-deficient hypertrophic muscular dystrophy. In an emergency setting, clinicians should be aware of muscular dystrophy in young cats and the importance of elevated creatine kinase (CK) activity. Muscular dystrophy is rare but can present both a diagnostic and therapeutic challenge in an emergency setting. Patients with muscular dystrophy have a progressive disease with no specific treatment and have an inc
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7

Qi, Yanfeng, and Liangfu Peng. "Design and Implementation of Precision Phase Measurement Module Base on Digital Dual Mixer Time Difference." Academic Journal of Science and Technology 5, no. 3 (2023): 152–57. http://dx.doi.org/10.54097/ajst.v5i3.7903.

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Precise phase difference measurement is critical for distributed time synchronization systems. Aiming at the problem of how to realize the sub-nanosecond phase difference measurement of the time signal, the digital dual mixer time difference (DDMTD) measurement technology is used to measure the fine transmission delay and the two digital clock phase difference. Given the problem that it is difficult to generate a common clock source with fine frequency changes inside the FPGA chip, the Si5338 chip is used to generate 4 differential clocks, and the communication with the FPGA is completed throu
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8

Arieli, Ran. "Oxygen Toxicity as a Function of Time and Po2." Journal of Basic and Clinical Physiology and Pharmacology 5, no. 1 (1994): 67–88. https://doi.org/10.1515/jbcpp-1994-050106.

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Abstract The quantification of 0 2 toxicity as a function of exposure time (t) and Po2 has been based mainly on the empirical rectangular hyperbola. The non-linear response of the 02-damaged physiological variable (DMG) as a function of time at constant Po2 can be related to the dependence of dDMG/dt on the DMG. The kinetics of the 02 - derived chemical species suggests a power relationship between the DMG and Po2 rather than a linear relationship. The combination of time and Po2 considerations suggests two models: 1) DMG = a(ebt - l)Po2 c and 2) DMG = a-tbPo2 c, where a, b and c are constant.
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9

Meng, Chaoyong, Chuanpei Xu, and Jiafeng Liao. "Research on Clock Synchronization of Data Acquisition Based on NoC." Applied Sciences 14, no. 11 (2024): 4838. http://dx.doi.org/10.3390/app14114838.

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Data acquisition based on network-on-chip (NoC) technology is a high-sampling-rate data acquisition scheme using low-sampling-rate analog–digital conversion (ADC) chips. It has the characteristics of multi-task parallel communication, being global asynchronous, local synchronous clock distribution, high throughput, low transmission latency, and strong scalability. High-speed data acquisition is realized through the combination of an on-chip network and time-interleaved data acquisition technology. In the time-interleaved sampling technique, the precision of clock synchronization directly affec
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10

McKinnon, J. J., J. A. Olubobokun, D. A. Christensen, and R. D. H. Cohen. "The influence of heat and chemical treatment on ruminal disappearance of canola meal." Canadian Journal of Animal Science 71, no. 3 (1991): 773–80. http://dx.doi.org/10.4141/cjas91-092.

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The influence of temperature (125 or 145 °C) and duration (10, 20 or 30 min) of heating, or chemical treatment (acetic (AA) or formic (FA) acid) on in vitro insoluble DM (IDM) and insoluble CP (ICP) and 12 h in situ ruminal disappearance of canola meal was examined. Ruminal disappearances of dry matter (DDM) and crude protein (CPD) were expressed as apparent (ADMD and ACPD), insoluble (IDMD and ICPD) and degradable (DDMD and DCPD). Insoluble DM content was reduced by AA and FA (P < 0.01), while ICP was reduced by FA (P < 0.01). Acid treatment had no effect on in situ DMD or CPD. Heating
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11

Li, Ruoyu, Yusong Liu, Haishan Gao, and Zhonghui Lin. "A gate-clamp mechanism for ssDNA translocation by DdmD in Vibrio cholerae plasmid defense." Nucleic Acids Research 53, no. 3 (2025). https://doi.org/10.1093/nar/gkaf064.

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Abstract The DdmDE antiplasmid system, consisting of the helicase-nuclease DdmD and the prokaryotic Argonaute (pAgo) protein DdmE, plays a crucial role in defending Vibrio cholerae against plasmids. Guided by DNA, DdmE specifically targets plasmids, disassembles the DdmD dimer, and forms a DdmD–DdmE handover complex to facilitate plasmid degradation. However, the precise ATP-dependent DNA translocation mechanism of DdmD has remained unclear. Here, we present cryo-EM structures of DdmD bound to single-stranded DNA (ssDNA) in nucleotide-free, ATPγS-bound, and ADP-bound states. These structures,
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12

Loeff, Luuk, David W. Adams, Christelle Chanez, et al. "Molecular mechanism of plasmid elimination by the DdmDE defense system." Science, June 13, 2024. http://dx.doi.org/10.1126/science.adq0534.

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Seventh pandemic Vibrio cholerae strains contain two pathogenicity islands that encode the DNA defense modules DdmABC and DdmDE. Here we use cryogenic electron microscopy to reveal the mechanistic basis for plasmid defense by DdmDE. A structure of the DdmD helicase-nuclease reveals it adopts an auto-inhibited dimeric architecture. The prokaryotic Argonaute protein DdmE uses a DNA guide to target plasmid DNA. A structure of the DdmDE complex, validated by in vivo mutational studies, shows that DNA binding by DdmE triggers disassembly of the DdmD dimer and loading of monomeric DdmD onto the non-
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13

Li, Xingang, Charles Xie, and Zhenghui Sha. "Design representation for performance evaluation of 3D shapes in structure-aware generative design." Design Science 9 (2023). http://dx.doi.org/10.1017/dsj.2023.25.

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Abstract Data-driven generative design (DDGD) methods utilize deep neural networks to create novel designs based on existing data. The structure-aware DDGD method can handle complex geometries and automate the assembly of separate components into systems, showing promise in facilitating creative designs. However, determining the appropriate vectorized design representation (VDR) to evaluate 3D shapes generated from the structure-aware DDGD model remains largely unexplored. To that end, we conducted a comparative analysis of surrogate models’ performance in predicting the engineering performanc
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14

Utter, Alexander C. "Beyond DDMTD – Sub-Picosecond Timestamps for Asynchronous Clocks." IEEE Access, 2023, 1. http://dx.doi.org/10.1109/access.2023.3345833.

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15

Zhang, Jie, Irina Shmagin, James Skinner, John Szczech, and Daniel Gamota. "Material Systems Used by Micro Dispensing and Ink Jetting Technologies." MRS Proceedings 624 (2000). http://dx.doi.org/10.1557/proc-624-41.

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ABSTRACTIn today's electronic industry, manufacturers are continuously improving capital utilization, developing flexible manufacturing processes, reduce changeover time and improving yield and throughput. Interest in rapid prototyping and 3-D fabrication capabilities are rapidly increasing, and a number of candidate direct writing technologies are in development to meet these demands.This work studies material systems used by data driven materials deposition (DDMD) technologies for potential low temperature reel-to-reel high volume manufacturing on low cost substrates. Characterization result
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16

Obaid, Fadhil Abdul Abass, Ali M. Al-Rahim, and Hassan Zaid Ali. "Subsurface Imaging of 2D Seismic Data of Balad-Samarra (BS-92) Survey Line, Ajeel Anticline Oilfield, Central Iraq, Using Kirchhoff Time Migration Method." Iraqi Journal of Science, December 30, 2020, 3318–26. http://dx.doi.org/10.24996/ijs.2020.61.12.19.

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Kirchhoff Time Migration method was applied in pre-and post-Stack Time Migration for post-processing of images collected from Balad-Samarra (BS-92) survey line that is sited across Ajeel anticline oilfield. The results showed that Ajeel anticline structure was relocated at the correct position in the migrated stacked section. The two methods (Pre and Post) of migration processing showed enhanced subsurface images and increased horizontal resolution, which was clear after the broadening the syncline and narrowing or compressing the anticline. However, each of these methods was associated with m
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17

Zhang, Xiang, Bobo Song, Shuai Du, et al. "Genomic insights into deleterious mutations and their impact on agronomic traits during pear domestication." Horticulture Research, May 29, 2025. https://doi.org/10.1093/hr/uhaf140.

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Abstract The pear (Pyrus spp.), a perennial fruit tree, is subjected to genetic alterations over decades or even centuries to adapt to complex climatic and cultivation conditions. Genome-wide studies of deleterious mutations remain limited in perennial fruit trees, particularly regarding the effects of domestication on deleterious mutations. In this study, 232 pear accessions were resequenced, and 9,909,773 SNPs, and 139,335 deleterious mutation sites, were identified genome-wide. A higher proportion of deleterious mutations in coding regions (1.4%) was observed in the pear genome than annual
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