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Relevant bibliographies by topics / De novo biosynthesis / Dissertations / Theses

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Dissertations / Theses on the topic 'De novo biosynthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Bedingfield, Paul Thomas Peter. "Inhibition of malaria de novo pyrimidine biosynthesis for drug development." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550336.

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In the absence of an effective vaccine there is ~ a considerable burden on drugs to provide protection from and treat the devastating disease, malaria. However, resistance has been seen to the majority of current antimalarials, making the continued development of new chemotherapeutics imperative. In this thesis dihydroorotate dehydrogenase (DHODH) is further examined as a potential drug target for the treatment of Plasmodium falciparum and Plasmodium vivax infection. DHODH is a key enzyme in de novo pyrimidine biosynthesis, the only pathway available to the parasites to generate vital pyrimidi

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2

Rodriguez, Rodriguez Mauricio. "Pyrimidine nucleotide de novo biosynthesis as a model of metabolic control." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4425.

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This manuscript presents a thorough investigation and description of metabolic control dynamics in vivo and in silico using as a model de novo pyrimidine biosynthesis. Metabolic networks have been studied intensely for decades, helping develop a detailed understanding of the way cells carry out their biosynthetic and catabolic functions. Biochemical reactions have been defined, pathway structures have been proposed, networks of genetic control have been examined, and mechanisms of enzymatic activity and regulation have been elucidated. In parallel with these types of traditional biochemical an

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3

Bosveld, Floris. "Physiological implications of impaired de novo coenzyme A biosynthesis in Drosophila melanogaster." [S.l. : Groningen : s.n. ; University Library of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/306087308.

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4

Nili, Nafisseh. "Limitations to amino acid biosynthesis de novo in ruminal strains of Prevotella and Butyrivibrio." Title page, contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phn712.pdf.

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Bibliography: leaves 226-261. Investigates nitrogen utilization in some species of rumen bacteria with the object of understanding the role of ammonia versus exogenous amino acids in relation to microbial growth.

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5

Hermansen, Russell A., Brian K. Mannakee, Wolfgang Knecht, David A. Liberles, and Ryan N. Gutenkunst. "Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast." BioMed Central Ltd, 2015. http://hdl.handle.net/10150/610280.

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BACKGROUND: Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes. RESULTS: Gene families across yeast were constructed for each member of the pathway and the ratio of nonsynonymous to synonymous nucleotide substitution rates (d

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6

Frame, Andrew Scott. "The synthesis of some imidazole nucleosides as potential inhibitors of de novo purine nucleotide biosynthesis." Thesis, University of Lincoln, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386384.

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7

Mitsuhashi, Satomi. "A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis." Kyoto University, 2012. http://hdl.handle.net/2433/152505.

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8

Sims, Kacee Hall. "Participation of de novo sphingolipid biosynthesis in the regulation of autophagy in response to diverse agents." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42839.

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Sphingolipids are a complex family of molecules that participate in many aspects of cell structure and function, including an essential cellular process known as autophagy. Autophagy is a degradation and recycling pathway whereby intracellular components are sequestered into double-membrane vesicles, known as autophagosomes, for subsequent fusion with lysosomes and degradation. Autophagy takes part in cell survival, host immune defense against pathogens, and other biological processes, but is also sometimes lethal. Ceramide, sphingosine 1-phosphate, and more recently dihydroceramide have been

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9

Wilson, Hilary Averil. "The chemistry of some 5-aminoimidazoles related to intermediates in the de novo biosynthesis of purines and thiamine." Thesis, University of Lincoln, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254784.

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10

Ghosh, Paritosh. "De Novo Glycogen Biosynthesis by a Glycogen Primer Complex in the Obliquely Striated Skeletal Muscle of Ascaris suum." Thesis, North Texas State University, 1987. https://digital.library.unt.edu/ark:/67531/metadc935639/.

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During the purification of the enzyme glycogen synthase from the muscle of the nematode Ascaris suum, approximately 70% of the glycogen synthase activity can be separated from the bulk of cellular glycogen by centrifugation for 60 min at 105,000 x . The glycogen synthase in the supernatant fraction has an Mr of 1.2 x 106 as determined by Sepharose 4B gel filtration chromatography. The glycogen synthase in this high molecular weight complex (glycogen primer complex) can be further purified by ConA-Sepharose affinity chromatography; the enzyme activity was eluted with 100 .mM a-methylmannoside.

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11

Mueller, Ernest James. "Mechanistic studies on de novo purine biosynthesis : probing for intermediates of AIR synthetase, FGAR amidotransferase and AIR carboxylase." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/17345.

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12

Sample, Paul J. "Characterization of two unique pathways for wyosine biosynthesis in Kinetoplastids." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397733440.

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13

Wimberley, James. "De novo Sequencing and Analysis of Salvia hispanica Transcriptome and Identification of Genes Involved in the Biosynthesis of Secondary Metabolites." Chapman University Digital Commons, 2019. https://digitalcommons.chapman.edu/cads_theses/5.

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Salvia hispanica L. (commonly known as chia) is gaining popularity worldwide and specially in US as a healthy oil and food supplement for human and animal consumption due to its favorable oil composition, and high protein, fiber, and antioxidant contents. Despite these benefits and its growing public demand, very limited gene sequence information is currently available in public databases. In this project, we generated 90 million high quality 150 bp paired-end sequences from the chia leaf and root tissues. The sequences were de novo assembled into 103,367 contigs with average length of 1,445 b

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14

Japiassu, Kamila Bohne. "Biossíntese catalisada por Beauveria bassiana ATCC 7159 de um novo flavonóide metilglicosilado potencialmente antioxidante e antifúngico." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8514.

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Submitted by Liliane Ferreira (ljuvencia30@gmail.com) on 2018-05-25T14:41:55Z No. of bitstreams: 2 Dissertação - Kamila Bohne Japiassu - 2018.pdf: 2922971 bytes, checksum: c56427b5a37af326aa313f8f9fb70e53 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-05-28T11:19:20Z (GMT) No. of bitstreams: 2 Dissertação - Kamila Bohne Japiassu - 2018.pdf: 2922971 bytes, checksum: c56427b5a37af326aa313f8f9fb70e53 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Made

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15

Quo, Chang Feng. "Reverse engineering homeostasis in molecular biological systems." Thesis, Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/49144.

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This dissertation is an initial study of how modern engineering control may be applied to reverse engineer homeostasis in metabolic pathways using high-throughput biological data. This attempt to reconcile differences between engineering control and biological homeostasis from an interdisciplinary perspective is motivated not only by the observation that robust behavior in metabolic pathways resembles stabilized dynamics in controlled systems, but also by the challenges forewarned in achieving a true meeting of minds between engineers and biologists. To do this, a comparator model is developed

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16

Künz, Madeleine [Verfasser], and Christian [Akademischer Betreuer] Betzel. "Investigations on an Innovative Antibiotic Approach : Structure-Function-Analysis of Essential Enzymes Routing the Vitamin B1 de novo Biosynthesis and Vitamin B6 Salvage Pathway of Staphylococcus aureus / Madeleine Künz. Betreuer: Christian Betzel." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/1075317398/34.

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17

Westley, Chantel Barbara, and chantel westley@flinders edu au. "The distribution, biosynthetic origin and functional significance of Tyrian purple precursors in the Australian muricid Dicathais orbita (Neogastropoda: Muricidae)." Flinders University. Biological Sciences, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20090414.153942.

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Information on the biosynthetic origin and functional advantage of marine mollusc natural products is not only essential to our understanding of chemical ecology, but to the development and responsible production of therapeutic agents. As demonstrating in situ activity is methodologically hindered, functions inferred by in vitro activity have been assumed for many secondary metabolites. The anatomical and ontogenetic distribution of natural products can not only provide information on the biosynthesis and storage of metabolites, but identify selective pressures likely to affect survivorship at

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18

Zemska, Olga. "Discovery Of Intracellular Growth Requirements of the Fungal Pathogen Histoplasma capsulatum." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343803044.

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19

Chen, Miao Liu Jian. "Towards de novo synthesis of structure-defined oligosaccharides with heparan sulfate biosynthetic enzymes." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1927.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the School of Pharmacy." Discipline: Pharmacy; Department/School: Pharmacy.

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20

Brill, Jeanette. "Biosynthese und Anhäufung der osmotischen Schutzsubstanz Prolin mittels De-novo-Synthese und Aufnahme prolinhaltiger Peptide in Bacillus subtilis." [S.l. : s.n.], 2001. http://archiv.ub.uni-marburg.de/diss/z2002/0080/.

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21

ABDI, AKILA. "Contribution a l'etude de la chaine de biosynthese de novo des nucleotides pyrimidiques chez lactobacillus plantarum ccm 1904." Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR13129.

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La croissance de lactobacillus plantarum, une bacterie lactique, est fonction de la presence dans le milieu de culture d'un certain nombre de metabolites. La connaissance du genome et des mecanismes de regulation de son expression devrait conduire a elucider les fondements biologiques de ces auxotrophies. Nous avons pris comme modele d'etude les genes de la voie de biosynthese de novo des pyrimidines bien caracterises chez d'autres organismes. Les resultats de la complementation des mutants pyr d'e. Coli et les resultats de sequencage montrent que les genes de la souche l. Plantarum ccm 1904 p

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22

Torres, Maria Alejandra Ferreira. "Análise genômica de Streptomyces olindensis DAUFPE 5622 e de suas vias crípticas para a obtenção de novos metabólicos secundários de interesse biotecnológico." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-10052016-090949/.

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Os compostos de origem microbiana tem readquirido interesse pela biodisponibilidade, especificidade de alvo e diversidade química, mas as vias biosintéticas permanecem crípticas em condições de cultura. Uma estratégia para expressa-las é a super-expressão de genes ativadores. O laboratório de Bio-Produtos no ICB na USP tem trabalhado com Streptomyces olindensis produtor da Cosmomicina D uma molécula com atividade antitumoral de interesse devido ao padrão de glicosilação. O genoma de S. olindensis foi sequenciado e submetido ao NCBI (JJOH00000000) e utilizando o software antiSMASH foram identif

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23

Schendel, Frederick John. "Mechanistic studies on de novo purine biosynthesis." 1986. http://catalog.hathitrust.org/api/volumes/oclc/16104266.html.

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24

Veeravalli, Karthik. "Engineering of de novo pathways for biosynthesis of glutathione analogues in Escherichia coli." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-05-999.

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The low molecular weight (L.M.W.) thiol redox couple formed by γ-L-glutamyl-L-cysteinyl glycine, also called glutathione (reduced and oxidized), is present in most eukaryotes and a few species of bacteria. Glutathione plays a role in numerous cellular processes by providing a means of shuttling electrons to different enzymatic systems. As a result, thiol-dependent redox metabolic processes are highly coupled. Due to tight coupling of redox reactions, it is difficult to understand how changes in the concentration of glutathione would affect a specific glutathione-dependent process. Interesting

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25

Zayas, Aponte Carmen Loyda. "Studies of the last step to de novo corrin ring biosynthesis and the nucleotide loop assembly pathway of coenzyme B₁₂ synthesis." 2007. http://www.library.wisc.edu/databases/connect/dissertations.html.

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26

Rentz, Sarah Suzanne. "The role of fumonisin B¹ and other inhibitors of de novo sphingolipid biosynthesis in the expression of p42 MAP kinase (pERK2) in LLC-PK₁ cells." 2002. http://purl.galileo.usg.edu/uga%5Fetd/rentz%5Fsarah%5Fs%5F200205%5Fms.

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Thesis (M.S.)--University of Georgia, 2002.<br>Directed by Ronald Riley. Includes an article submitted to Toxicology & applied pharmacology. For abstract see http://getd.galib.uga.edu/public/rentz_sarah_s_200205_ms/rentz_sarah_s_200205_ms.pdf. Includes bibliographical references.

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27

Brill, Jeanette [Verfasser]. "Biosynthese und Anhäufung der osmotischen Schutzsubstanz Prolin mittels De-novo-Synthese und Aufnahme prolinhaltiger Peptide in Bacillus subtilis / vorgelegt von Jeanette Brill." 2001. http://d-nb.info/97279249X/34.

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