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Journal articles on the topic 'De novo biosynthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Rooney, S. A. "Fatty acid biosynthesis in developing fetal lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 257, no. 4 (1989): L195—L201. http://dx.doi.org/10.1152/ajplung.1989.257.4.l195.

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Fatty acids are integral components of glycerolipids and hence of the phosphatidylcholine-rich pulmonary surfactant. There is ample evidence that the lung is able to synthesize fatty acids de novo. Toward the end of gestation as the fetus prepares for life outside the uterus, there is a surge in phosphatidylcholine synthesis. At the same time there is an increase in de novo fatty acid biosynthesis as well as in the activity of fatty acid synthase, the enzyme that catalyzes the final steps in fatty acid synthesis. Glucocorticoids have long been known to accelerate phosphatidylcholine biosynthes

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2

Dircks, Lori, and Hei Sook Sul. "Acyltransferases of de novo glycerophospholipid biosynthesis." Progress in Lipid Research 38, no. 5-6 (1999): 461–79. http://dx.doi.org/10.1016/s0163-7827(99)00012-0.

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3

Brückner, Adrian, Martin Kaltenpoth, and Michael Heethoff. "De novo biosynthesis of simple aromatic compounds by an arthropod ( Archegozetes longisetosus )." Proceedings of the Royal Society B: Biological Sciences 287, no. 1934 (2020): 20201429. http://dx.doi.org/10.1098/rspb.2020.1429.

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The ability to synthesize simple aromatic compounds is well known from bacteria, fungi and plants, which all share an exclusive biosynthetic route—the shikimic acid pathway. Some of these organisms further evolved the polyketide pathway to form core benzenoids via a head-to-tail condensation of polyketide precursors. Arthropods supposedly lack the ability to synthesize aromatics and instead rely on aromatic amino acids acquired from food, or from symbiotic microorganisms. The few studies purportedly showing de novo biosynthesis via the polyketide synthase (PKS) pathway failed to exclude endosy

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4

Wheeler, Paul R. "Pyrimidine biosynthesis de novo in M. leprae." FEMS Microbiology Letters 57, no. 2 (1989): 185–89. http://dx.doi.org/10.1111/j.1574-6968.1989.tb03296.x.

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5

Liu, D. S., and C. A. Caperelli. "Carbocyclic substrates for de novo purine biosynthesis." Journal of Biological Chemistry 266, no. 25 (1991): 16699–702. http://dx.doi.org/10.1016/s0021-9258(18)55357-6.

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6

Palmer, Ashley M., Elena Kamynina, Martha S. Field, and Patrick J. Stover. "Folate rescues vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability." Proceedings of the National Academy of Sciences 114, no. 20 (2017): E4095—E4102. http://dx.doi.org/10.1073/pnas.1619582114.

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Clinical vitamin B12 deficiency can result in megaloblastic anemia, which results from the inhibition of DNA synthesis by trapping folate cofactors in the form of 5-methyltetrahydrofolate (5-methylTHF) and subsequent inhibition of de novo thymidylate (dTMP) biosynthesis. In the cytosol, vitamin B12 functions in the remethylation of homocysteine to methionine, which regenerates THF from 5-methylTHF. In the nucleus, THF is required for de novo dTMP biosynthesis, but it is not understood how 5-methylTHF accumulation in the cytosol impairs nuclear dTMP biosynthesis. The impact of vitamin B12 deple

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7

Rehm, Bernd H. A., Timothy A. Mitsky, and Alexander SteinbÃ¯Â¿Â½chel. "Role of Fatty Acid De Novo Biosynthesis in Polyhydroxyalkanoic Acid (PHA) and Rhamnolipid Synthesis by Pseudomonads: Establishment of the Transacylase (PhaG)-Mediated Pathway for PHA Biosynthesis inEscherichia coli." Applied and Environmental Microbiology 67, no. 7 (2001): 3102–9. http://dx.doi.org/10.1128/aem.67.7.3102-3109.2001.

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ABSTRACT Since Pseudomonas aeruginosa is capable of biosynthesis of polyhydroxyalkanoic acid (PHA) and rhamnolipids, which contain lipid moieties that are derived from fatty acid biosynthesis, we investigated various fab mutants from P. aeruginosa with respect to biosynthesis of PHAs and rhamnolipids. All isogenicfabA, fabB, fabI, rhlG, and phaG mutants fromP. aeruginosa showed decreased PHA accumulation and rhamnolipid production. In the phaG (encoding transacylase) mutant rhamnolipid production was only slightly decreased. Expression of phaG from Pseudomonas putida and expression of the β-ke

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8

Qazzaz, Hassan M. A. M., (Tim) Zhimin Cao, Duane D. Bolanowski, Barbara J. Clark, and Roland Valdes. "De Novo Biosynthesis and Radiolabeling of Mammalian Digitalis-Like Factors." Clinical Chemistry 50, no. 3 (2004): 612–20. http://dx.doi.org/10.1373/clinchem.2003.022715.

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Abstract Background: Digoxin-like immunoreactive factors (DLIFs) are endogenous mammalian cardenolides with structural features similar to those of the plant-derived digitalis compounds. DLIFs and their structurally related forms (Dh-DLIFs) may serve as effectors of ion-transport activity mediated by their interaction with Na,K-ATPase and thus play a role as a new hormonal axis. Although some evidence implicates the adrenal gland as a tissue source for the DLIFs, little is known about the biosynthetic pathway producing these compounds. We now demonstrate de novo biosynthesis of DLIF by incorpo

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9

Fitzpatrick, Teresa B., Nikolaus Amrhein, Barbara Kappes, Peter Macheroux, Ivo Tews, and Thomas Raschle. "Two independent routes of de novo vitamin B6 biosynthesis: not that different after all." Biochemical Journal 407, no. 1 (2007): 1–13. http://dx.doi.org/10.1042/bj20070765.

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Vitamin B6 is well known in its biochemically active form as pyridoxal 5′-phosphate, an essential cofactor of numerous metabolic enzymes. The vitamin is also implicated in numerous human body functions ranging from modulation of hormone function to its recent discovery as a potent antioxidant. Its de novo biosynthesis occurs only in bacteria, fungi and plants, making it an essential nutrient in the human diet. Despite its paramount importance, its biosynthesis was predominantly investigated in Escherichia coli, where it is synthesized from the condensation of deoxyxylulose 5-phosphate and 4-ph

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10

Sánchez-Castillo, Anaís, Marc Vooijs, and Kim R. Kampen. "Linking Serine/Glycine Metabolism to Radiotherapy Resistance." Cancers 13, no. 6 (2021): 1191. http://dx.doi.org/10.3390/cancers13061191.

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The activation of de novo serine/glycine biosynthesis in a subset of tumors has been described as a major contributor to tumor pathogenesis, poor outcome, and treatment resistance. Amplifications and mutations of de novo serine/glycine biosynthesis enzymes can trigger pathway activation; however, a large group of cancers displays serine/glycine pathway overexpression induced by oncogenic drivers and unknown regulatory mechanisms. A better understanding of the regulatory network of de novo serine/glycine biosynthesis activation in cancer might be essential to unveil opportunities to target tumo

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11

Hauff, Kristin, Dorota Linda, and Grant M. Hatch. "Mechanism of the elevation in cardiolipin during HeLa cell entry into the S-phase of the human cell cycle." Biochemical Journal 417, no. 2 (2008): 573–82. http://dx.doi.org/10.1042/bj20080650.

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CL (cardiolipin) is a key phospholipid involved in ATP generation. Since progression through the cell cycle requires ATP we examined regulation of CL synthesis during S-phase in human cells and investigated whether CL or CL synthesis was required to support nucleotide synthesis in S-phase. HeLa cells were made quiescent by serum depletion for 24 h. Serum addition resulted in substantial stimulation of [methyl-3H]thymidine incorporation into cells compared with serum-starved cells by 8 h, confirming entry into the S-phase. CL mass was unaltered at 8 h, but increased 2-fold by 16 h post-serum ad

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12

Taipale, R., M. K. Kajos, J. Patokoski, P. Rantala, T. M. Ruuskanen, and J. Rinne. "Role of de novo biosynthesis in ecosystem scale monoterpene emissions from a boreal Scots pine forest." Biogeosciences 8, no. 8 (2011): 2247–55. http://dx.doi.org/10.5194/bg-8-2247-2011.

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Abstract. Monoterpene emissions from Scots pine have traditionally been assumed to originate as evaporation from specialized storage pools. More recently, the significance of de novo emissions, originating directly from monoterpene biosynthesis, has been recognized. To study the role of biosynthesis at the ecosystem scale, we measured monoterpene emissions from a Scots pine dominated forest in southern Finland using the disjunct eddy covariance method combined with proton transfer reaction mass spectrometry. The interpretation of the measurements was based on a correlation analysis and a hybri

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Taipale, R., M. K. Kajos, J. Patokoski, P. Rantala, T. M. Ruuskanen, and J. Rinne. "Role of de novo biosynthesis in ecosystem scale monoterpene emissions from a boreal Scots pine forest." Biogeosciences Discussions 7, no. 6 (2010): 8019–40. http://dx.doi.org/10.5194/bgd-7-8019-2010.

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Abstract. Monoterpene emissions from Scots pine have traditionally been assumed to originate as evaporation from specialized storage pools. More recently, the significance of de novo emissions, originating directly from monoterpene biosynthesis, has been recognized. To study the role of biosynthesis in the ecosystem scale, we measured monoterpene emissions from a Scots pine dominated forest in southern Finland using the disjunct eddy covariance method combined with proton transfer reaction mass spectrometry. The interpretation of the measurements was based on a hybrid emission algorithm descri

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14

Petersen, Leslie, Jodi Enos-Berlage, and Diana M. Downs. "Genetic Analysis of Metabolic Crosstalk and Its Impact on Thiamine Synthesis in Salmonella typhimurium." Genetics 143, no. 1 (1996): 37–44. http://dx.doi.org/10.1093/genetics/143.1.37.

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Abstract The first five steps in de novo purine biosynthesis are involved in the formation of the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. We show here that the first enzyme in de novo purine biosynthesis, PurF, is required for thiamine synthesis during aerobic growth on some but not other carbon sources. We show that PurF-independent thiamine synthesis depends on the recently described alternative pyrimidine biosynthetic (APB) pathway. Null mutations in zwf (encoding glucose-6-P dehydogenase), gnd (encoding gluconate-6-P dehydrogenase), purE (encoding aminoimidazo

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15

Gorissen, Antonie, Nicolai U. Kraut, Ries de Visser, Marcel de Vries, Han Roelofsen, and Roel J. Vonk. "No de novo sulforaphane biosynthesis in broccoli seedlings." Food Chemistry 127, no. 1 (2011): 192–96. http://dx.doi.org/10.1016/j.foodchem.2010.12.067.

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16

Bai, Yanfen, Hua Yin, Huiping Bi, Yibin Zhuang, Tao Liu, and Yanhe Ma. "De novo biosynthesis of Gastrodin in Escherichia coli." Metabolic Engineering 35 (May 2016): 138–47. http://dx.doi.org/10.1016/j.ymben.2016.01.002.

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17

Benkovic, S. J., L. Gooljarsingh, J. Ramcharan, J. H. Shim, and M. Wall. "The Transformylase Enzymes in de Novo Purine Biosynthesis." Biochemical Society Transactions 28, no. 5 (2000): A122. http://dx.doi.org/10.1042/bst028a122c.

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18

Christopherson, Richard I., Stephen D. Lyons, and Paul K. Wilson. "Inhibitors of de Novo Nucleotide Biosynthesis as Drugs." Accounts of Chemical Research 35, no. 11 (2002): 961–71. http://dx.doi.org/10.1021/ar0000509.

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19

Winn, Michael, Daniel Francis, and Jason Micklefield. "De novo Biosynthesis of “Non-Natural” Thaxtomin Phytotoxins." Angewandte Chemie International Edition 57, no. 23 (2018): 6830–33. http://dx.doi.org/10.1002/anie.201801525.

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20

Winn, Michael, Daniel Francis, and Jason Micklefield. "De novo Biosynthesis of “Non-Natural” Thaxtomin Phytotoxins." Angewandte Chemie 130, no. 23 (2018): 6946–49. http://dx.doi.org/10.1002/ange.201801525.

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21

Warren, M. S., K. M. Mattia, A. E. Marolewski, and S. J. Benkovic. "The transformylase enzymes of de novo purine biosynthesis." Pure and Applied Chemistry 68, no. 11 (1996): 2029–36. http://dx.doi.org/10.1351/pac199668112029.

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22

Yin, Yan, Yanpeng Li, Dan Jiang, Xianan Zhang, Wei Gao, and Chunsheng Liu. "De novo biosynthesis of liquiritin in Saccharomyces cerevisiae." Acta Pharmaceutica Sinica B 10, no. 4 (2020): 711–21. http://dx.doi.org/10.1016/j.apsb.2019.07.005.

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23

Surolia, Namita. "De novo biosynthesis of Heme in Plasmodium falciparum." Parasitology Today 12, no. 12 (1996): 495. http://dx.doi.org/10.1016/0169-4758(96)88862-4.

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24

Cripps, Colleen, Gary J. Blomquist, and Mertxe de Renobales. "De novo biosynthesis of linoleic acid in insects." Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 876, no. 3 (1986): 572–80. http://dx.doi.org/10.1016/0005-2760(86)90046-9.

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25

Liu, Tian, Yuqian Liu, Lan Li, et al. "De Novo Biosynthesis of Polydatin in Saccharomyces cerevisiae." Journal of Agricultural and Food Chemistry 69, no. 21 (2021): 5917–25. http://dx.doi.org/10.1021/acs.jafc.1c01557.

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26

Field, Martha S., Elena Kamynina, David Watkins, David S. Rosenblatt, and Patrick J. Stover. "Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis." Proceedings of the National Academy of Sciences 112, no. 2 (2014): 400–405. http://dx.doi.org/10.1073/pnas.1414555112.

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An inborn error of metabolism associated with mutations in the human methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) gene has been identified. The proband presented with SCID, megaloblastic anemia, and neurologic abnormalities, but the causal metabolic impairment is unknown. SCID has been associated with impaired purine nucleotide metabolism, whereas megaloblastic anemia has been associated with impaired de novo thymidylate (dTMP) biosynthesis. MTHFD1 functions to condense formate with tetrahydrofolate and serves as the primary entry point of single carbons into folate-dependent one-carbon

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27

Bourlon, PM, B. Billaudel, and A. Faure-Dussert. "Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas." Journal of Endocrinology 160, no. 1 (1999): 87–95. http://dx.doi.org/10.1677/joe.0.1600087.

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Because 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) is known to activate the biosynthesis of numerous proteins in various tissues, experiments were undertaken to compare the influence of 1,25(OH)2D3 in vitro on both the secretion and biosynthesis of insulin in islets of Langerhans from both 4-week vitamin D3-deficient rats and normal rats. Islets were either incubated or perifused after a 6-h induction period in the presence of various concentrations of 1, 25(OH)2D3 from 10(-12) M, which was inactive in controls, to 10(-6) M. Experiments were performed in the presence of a non-labelled amino acid m

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28

WEBSTER, Jennifer, Jenny Y. JIANG, Biao LU, et al. "On the mechanism of the increase in cardiolipin biosynthesis and resynthesis in hepatocytes during rat liver regeneration." Biochemical Journal 386, no. 1 (2005): 137–43. http://dx.doi.org/10.1042/bj20040655.

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CL (cardiolipin) is a major mitochondrial membrane phospholipid important for the regulation of mitochondrial function. We examined CL de novo biosynthesis and its resynthesis in isolated rat liver hepatocytes prepared 48 h subsequent to two-thirds PHx (partial hepatectomy). The pool size of CL and its de novo biosynthesis from [1,3-3H]glycerol were increased 3.3-fold (P<0.05) and 3.1-fold (P<0.05) respectively in hepatocytes prepared from PHx rats compared with sham-operated controls. The reason for the increased CL biosynthesis was a 65% increase (P<0.05) in enzymic activity in PGP-

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Bibi, Nousheen, Zahida Parveen, Muhammad Sulaman Nawaz, and Mohammad Amjad Kamal. "In Silico Structure Modeling and Molecular Docking Analysis of Phosphoribosyl Pyrophosphate Amidotransferase (PPAT) with Antifolate Inhibitors." Current Cancer Drug Targets 19, no. 5 (2019): 408–16. http://dx.doi.org/10.2174/1568009619666181127115015.

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Background: Cancer remains one of the most serious disease worldwide. Robust metabolism is the hallmark of cancer. PPAT (phosphoribosyl pyrophosphate amidotransferase) catalyzes the first committed step of de novo purine biosynthesis. Hence PPAT, the key regulatory spot in De novo purine nucleotide biosynthesis, is an attractive and credible drug target for leukemia and other cancer therapeutics. Objective: In the present study, detailed computational analysis has been performed for PPAT protein, the key enzyme in de novo purine biosynthesis which is inhibited by many folate derivatives, hence

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MINA, JOHN G. M., and P. W. DENNY. "Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis." Parasitology 145, no. 2 (2017): 134–47. http://dx.doi.org/10.1017/s0031182017001081.

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SUMMARYSphingolipids (SLs) are an integral part of all eukaryotic cellular membranes. In addition, they have indispensable functions as signalling molecules controlling a myriad of cellular events. Disruption of either the de novo synthesis or the degradation pathways has been shown to have detrimental effects. The earlier identification of selective inhibitors of fungal SL biosynthesis promised potent broad-spectrum anti-fungal agents, which later encouraged testing some of those agents against protozoan parasites. In this review we focus on the key enzymes of the SL de novo biosynthetic path

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31

Zhang, Yafen, Bo Liu, Xiaohui Li, et al. "The de novo Biosynthesis of Vitamin B6 Is Required for Disease Resistance Against Botrytis cinerea in Tomato." Molecular Plant-Microbe Interactions® 27, no. 7 (2014): 688–99. http://dx.doi.org/10.1094/mpmi-01-14-0020-r.

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Vitamin B6 (VB6), an essential cofactor for numerous metabolic enzymes, has recently been shown to act as a potent antioxidant and play important roles in developmental processes and stress responses. However, little is known about the possible function of VB6 in plant disease resistance response against pathogen infection. In the present study, we explored the possible involvement of VB6 in defense response against Botrytis cinerea through functional analysis of tomato VB6 biosynthetic genes. Three de novo VB6 biosynthetic genes (SlPDX1.2, SlPDX1.3, and SlPDX2) and one salvage pathway gene (S

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32

Thomas, Michael G., та Jorge C. Escalante-Semerena. "Identification of an Alternative Nucleoside Triphosphate: 5′-Deoxyadenosylcobinamide Phosphate Nucleotidyltransferase in Methanobacterium thermoautotrophicum ΔH". Journal of Bacteriology 182, № 15 (2000): 4227–33. http://dx.doi.org/10.1128/jb.182.15.4227-4233.2000.

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ABSTRACT Computer analysis of the archaeal genome databases failed to identify orthologues of all of the bacterial cobamide biosynthetic enzymes. Of particular interest was the lack of an orthologue of the bifunctional nucleoside triphosphate (NTP):5′-deoxyadenosylcobinamide kinase/GTP:adenosylcobinamide-phosphate guanylyltransferase enzyme (CobU in Salmonella enterica). This paper reports the identification of an archaeal gene encoding a new nucleotidyltransferase, which is proposed to be the nonorthologous replacement of the S. enterica cobU gene. The gene encoding this nucleotidyltransferas

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33

Doigneaux, Cyrielle, Anthony M. Pedley, Ishna N. Mistry, Monika Papayova, Stephen J. Benkovic, and Ali Tavassoli. "Hypoxia drives the assembly of the multienzyme purinosome complex." Journal of Biological Chemistry 295, no. 28 (2020): 9551–66. http://dx.doi.org/10.1074/jbc.ra119.012175.

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The purinosome is a dynamic metabolic complex composed of enzymes responsible for de novo purine biosynthesis, whose formation has been associated with elevated purine demand. However, the physiological conditions that govern purinosome formation in cells remain unknown. Here, we report that purinosome formation is up-regulated in cells in response to a low-oxygen microenvironment (hypoxia). We demonstrate that increased purinosome assembly in hypoxic human cells requires the activation of hypoxia inducible factor 1 (HIF-1) and not HIF-2. Hypoxia-driven purinosome assembly was inhibited in cel

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34

Tong, Haonan, Hao Chen, and Cranos M. Williams. "Gene Regulatory Network of Secondary Cell Wall Biosynthesis during VND7 Induced de novo Xylem Formation." International Journal of Bioscience, Biochemistry and Bioinformatics 11, no. 4 (2021): 74–81. http://dx.doi.org/10.17706/ijbbb.2021.11.4.74-81.

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35

Kobek, Klaus, and Hartmut K. Lichtenthaler. "Inhibition of de novo Fatty Acid Biosynthesis in Isolated Etioplasts by Herbicides." Zeitschrift für Naturforschung C 44, no. 7-8 (1989): 669–72. http://dx.doi.org/10.1515/znc-1989-7-820.

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It is demonstrated that - similar to chloroplasts - etioplasts isolated from leaves of pea (Pisumsativum L.) and oat seedlings (Avena sativa L.) also possess a high capacity for de novo fatty acid biosynthesis starting from [1-14C]acetate. The etioplast system proved to be a suitable test system for inhibitors of de novo fatty acid biosynthesis such as cycloxydim , sethoxydim and diclofop. In contrast to the chloroplast test system , the etioplast system is independent of light and also permits screening of photosynthetic herbicides as potential inhibitors of fatty acid biosynthesis.

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36

Santiago, Manuel F., and Thomas P. West. "Control of pyrimidine formation in Pseudomonas putida ATCC 17536." Canadian Journal of Microbiology 48, no. 12 (2002): 1076–81. http://dx.doi.org/10.1139/w02-110.

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The regulation of de novo pyrimidine biosynthesis in Pseudomonas putida ATCC 17536 by pyrimidines was explored. The pathway enzyme activities were higher in glucose-grown cells than in succinate-grown cells, indicating catabolite repression by succinate. In P. putida cells grown on succinate as a carbon source, only aspartate transcarbamoylase activity was greatly diminished by uracil supplementation. When glucose was the carbon source, orotic acid supplementation significantly decreased orotate phosphoribosyltransferase and orotidine 5'-monophosphate (OMP) decarboxylase activities. Uracil aux

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Wachsman, M., F. M. Hamzeh, N. B. Assadi, and P. S. Lietman. "Antiviral Activity of Inhibitors of Pyrimidine De-Novo Biosynthesis." Antiviral Chemistry and Chemotherapy 7, no. 1 (1996): 7–13. http://dx.doi.org/10.1177/095632029600700102.

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Evaluation of the elevation of host cell biosynthesis of deoxynucleoside triphosphates (dNTP's) induced by human cytomegalovirus (HCMV) infection as a target for antiviral therapeutics was carried out. The concentrations of all four intracellular dNTP's rose rapidly following HCMV infection, and were markedly above baseline by 8 h post infection (p.i.). All four deoxynucleoside triphosphates remained elevated above baseline for at least 72 h p.i. The effects of inhibitors of the de-novo pathway of pyrimidine biosynthesis on HCMV viral replication-were quantified by DNA dot blot. All pyrimidine

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38

Gronwald, John W. "Lipid Biosynthesis Inhibitors." Weed Science 39, no. 3 (1991): 435–49. http://dx.doi.org/10.1017/s0043174500073203.

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Five classes of herbicides (carbamothioates, chloroacetamides, substituted pyridazinones, cyclohexanediones, and aryloxyphenoxypropionic acids) have been reported to inhibit lipid biosynthesis in higher plants. Carbamothioates impair the synthesis of surface lipids (waxes, cutin, suberin). These effects have been attributed to the ability of this herbicide class to inhibit one or more acyl-CoA elongases. Though as yet poorly characterized, these enzymes are associated with the endoplasmic reticulum and catalyze the condensation of malonyl-CoA with fatty acid acyl-CoA substrates to form very lo

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39

Awad, Agape M., Michelle C. Bradley, Lucía Fernández-del-Río, Anish Nag, Hui S. Tsui, and Catherine F. Clarke. "Coenzyme Q10 deficiencies: pathways in yeast and humans." Essays in Biochemistry 62, no. 3 (2018): 361–76. http://dx.doi.org/10.1042/ebc20170106.

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Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant. In human and yeast cells, CoQ synthesis derives from aromatic ring precursors and the isoprene biosynthetic pathway. Saccharomyces cerevisiae coq mutants provide a powerful model for our understanding of CoQ biosynthesis. This review focusses on the biosynthesis of CoQ in yeast and the relevance of this model to CoQ biosynthesis in human cells. The COQ1–COQ11 yeast genes are required for efficient biosynthesis of yeast CoQ. Expression of

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40

Sasset, Linda, Yi Zhang, Teresa M. Dunn, and Annarita Di Lorenzo. "Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis." Trends in Endocrinology & Metabolism 27, no. 11 (2016): 807–19. http://dx.doi.org/10.1016/j.tem.2016.07.005.

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41

Ramos, Rúben J., Mia L. Pras-Raves, Johan Gerrits, et al. "Vitamin B6 is essential for serine de novo biosynthesis." Journal of Inherited Metabolic Disease 40, no. 6 (2017): 883–91. http://dx.doi.org/10.1007/s10545-017-0061-3.

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42

Azzouz, Nahid, Beatrice Rauscher, Peter Gerold, Marie-France Cesbron-Delauw, Jean-François Dubremetz, and Ralph T. Schwarz. "Evidence for de novo sphingolipid biosynthesis in Toxoplasma gondii." International Journal for Parasitology 32, no. 6 (2002): 677–84. http://dx.doi.org/10.1016/s0020-7519(02)00009-7.

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43

Cortes, Pedro, Francis Dumler, and Nathan W. Levin. "De novo pyrimidine nucleotide biosynthesis in isolated rat glomeruli." Kidney International 30, no. 1 (1986): 27–34. http://dx.doi.org/10.1038/ki.1986.146.

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44

Zhu, Xuejun, Joyce Liu, and Wenjun Zhang. "De novo biosynthesis of terminal alkyne-labeled natural products." Nature Chemical Biology 11, no. 2 (2014): 115–20. http://dx.doi.org/10.1038/nchembio.1718.

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45

Saibuatong, Ong-ard, and Muenduen Phisalaphong. "Novo aloe vera–bacterial cellulose composite film from biosynthesis." Carbohydrate Polymers 79, no. 2 (2010): 455–60. http://dx.doi.org/10.1016/j.carbpol.2009.08.039.

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Tribunskikh, I. A., V. V. Alenin, S. I. Selivanov, A. G. Shavva, and S. G. Inge-Vechtomov. "Divergence of de novo biosynthesis of inosine-5’-triphosphate." Doklady Biochemistry and Biophysics 400, no. 1-6 (2005): 65–68. http://dx.doi.org/10.1007/s10628-005-0034-6.

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Tong, Xuemei. "Regulation of de novo nucleotide biosynthesis in cancer cells." Genes & Diseases 4, no. 1 (2017): 13. http://dx.doi.org/10.1016/j.gendis.2016.10.010.

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Mádrová, Lucie, Matyáš Krijt, Veronika Barešová, et al. "Mass spectrometric analysis of purine de novo biosynthesis intermediates." PLOS ONE 13, no. 12 (2018): e0208947. http://dx.doi.org/10.1371/journal.pone.0208947.

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Ding, Yong, Xinli Li, Geoff P. Horsman, et al. "Construction of an Alternative NAD + De Novo Biosynthesis Pathway." Advanced Science 8, no. 9 (2021): 2004632. http://dx.doi.org/10.1002/advs.202004632.

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Brown, Stephanie, Marc Clastre, Vincent Courdavault, and Sarah E. O’Connor. "De novo production of the plant-derived alkaloid strictosidine in yeast." Proceedings of the National Academy of Sciences 112, no. 11 (2015): 3205–10. http://dx.doi.org/10.1073/pnas.1423555112.

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Abstract:

The monoterpene indole alkaloids are a large group of plant-derived specialized metabolites, many of which have valuable pharmaceutical or biological activity. There are ∼3,000 monoterpene indole alkaloids produced by thousands of plant species in numerous families. The diverse chemical structures found in this metabolite class originate from strictosidine, which is the last common biosynthetic intermediate for all monoterpene indole alkaloid enzymatic pathways. Reconstitution of biosynthetic pathways in a heterologous host is a promising strategy for rapid and inexpensive production of comple

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