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1
Paul, Rik. "Taj: I will prevail. Exemplifying customer service in times of crisis." Emerald Emerging Markets Case Studies 2, no. 8 (October 17, 2012): 1–11. http://dx.doi.org/10.1108/20450621211304289.
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Subject area Marketing Study level/applicability The case is suitable for MBA/MS students. Case overview The famous Taj Mahal Palace and Towers became the centre of one of the most deadly terrorist attacks in the Indian sub continent on the night of 26 November 2008, which became famous as “26/11”. Terrorists created havoc shooting guests on sight and throwing grenades. The attacks lasted for three days but all of the four terrorists who entered Taj were killed. The terrorists had killed 160 people across Mumbai. Of these, 36 died at the Taj Mahal Palace and Towers, Mumbai. The dead included 14 guests, most of whom were foreign nationals. However, due to the selfless and extraordinary behavior of the employees and the staff of Taj, many guests were saved. They put forth an extraordinary example justifying the Indian code of conduct towards guests, “Atithi Devo Bhav” meaning “Guest is God”. In spite of knowing back exits and hiding spots, the employees did not flee, instead helping guests. The employees' behavior during the crisis saved the lives of nearly300 guests. This gesture of Taj employees was much talked about, but it was amusing even for the management to explain why they behaved in that manner. The condition of Taj after the attacks was so disastrous that it would have been profitable to leave the hotel as it was rather than reopening it. This, however, would have dented the Taj brand as a whole, as well as the spirit of all employees and staff who had behaved bravely. Taj started its restoration and reopened a part of the Taj Mahal Palace and Towers on 21 December 2008. It became operational by August 2010. The case provides an opportunity to closely examine employee behavior in an extreme crisis situation, and the possible reasons and motivation behind such exceptional behavior which ultimately helped to sustain the Taj brand. However, the scope of the case can also be extended to illustrate recovery efforts typical to service industries. Expected learning outcomes The case is designed to enable students to understand: the employees role in service delivery; the service profit chain; the relationship between profitability, customer loyalty, employee satisfaction and loyalty, and productivity; service failure; service recovery; and the service recovery paradox. Supplementary materials Teaching notes are available. Please consult your librarian for access.
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SriĆa, Velimir. "Ten Deadly Sins of Education." Donald School Journal of Ultrasound in Obstetrics and Gynecology 7, no. 3 (2013): 261–67. http://dx.doi.org/10.5005/jp-journals-10009-1291.
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ABSTRACT Education is necessary but ‘schools’ (as we know them) are not. How much of what we formally learn is ever useful in real life? Some studies show that it's only between 8 and 12%. The article tries to analyze the challenges and issues facing contemporary education. What are the ‘deadly sins’: The existing educational system is not very useful as far as the quality of its outcome is concerned; it is not flexible in embracing the Wiki world and high technology; education is slow in moving from bureaucracy toward entrepreneurship and creativity; separation between learning and working should be abandoned; instead of cramming, the students should be stimulated to analyze, reason, research, inquire and ‘think with their own head’; learning is important, but so is unlearning; teachers must be able to teach the rational stuff in a cool and inspirational way; the students should be trained for attitude, not just knowledge and skills; education must re-establish the lost connection between art and science, wisdom and practicality; education should go lower on theory, and higher on applicability. If we want to create a better educational system, changing culture is by far more important than changing curricula. How to cite this article Sriƒa V. Ten Deadly Sins of Education. Donald School J Ultrasound Obstet Gynecol 2013;7(3):261-267.
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Dreyer, Benard P. "Sustained Animus toward Latino Immigrants — Deadly Consequences for Children and Families." New England Journal of Medicine 381, no. 13 (September 26, 2019): 1196–98. http://dx.doi.org/10.1056/nejmp1908995.
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Raitskaya, Lilia, and Elena Tikhonova. "Seven Deadly Sins: Culture’s Effect on Scholarly Editing and Publishing." Journal of Language and Education 6, no. 3 (September 30, 2020): 167–72. http://dx.doi.org/10.17323/jle.2020.11205.
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The opinion piece aims to draw readers’ attention to the effects cultures other than English-related ones exert on the processes of scholarly editing and publishing. Non-Anglophone writers with little academic English skills or a weak command of English tend to face desk-rejections or very difficult and time-consuming rounds of edits and revisions. Second-language researchers often are biased toward national schools of thought with the most prominent international research ignored. Such authors are unaware of the recent developments in their field on a global scale and are sometimes prone to misunderstanding scientific and academic genres in the internationally accepted mode. Non-Anglophone writers are also inclined toward native-language patterns of thought and, consequently, rhetorical schemas different from English. Such second-language researchers may have their specific understanding of ethics and criticism, responding to the latter in an unexpectedly harsh way. This combination of factors can lead to unoriginal, vague, unimportant, and unacceptable submissions to international journals, resulting in failures to disseminate their research globally. The authors share their approaches to curbing unpleasant and inefficient experiences for second-language contributors, editors, and reviewers.
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Joseph George Kallivayalil, Abilasha R, and Kavitha S. "Knowledge and awareness of Covid -19 symptoms among dental students - A questionnaire based survey." International Journal of Research in Pharmaceutical Sciences 11, SPL1 (September 22, 2020): 816–21. http://dx.doi.org/10.26452/ijrps.v11ispl1.3087.
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COVID -19 is the most recent pandemic disease that has affected the world's population. We, as health care providers should be more responsible for reducing the transmission of this deadly disease. The aim of the survey was to assess the knowledge and awareness among dental professionals towards COVID -19 and reduce the spread among patients and co-workers. A cross-sectional study was conducted in a sample of 100 dental students by means of a questionnaire, using google forms, results were tabulated and analysed using SPSS. 24.8% prefer and rely on the fact that fever has been the main symptoms of COVID -19 while 32.7% of the respondents prefer on the fact that cough has been the symptoms leading to COVID -19 64% of the dental students are aware on the fact that patients should be checked on their temperature before the consultation. 36.3% of the dental students prefer no checking of temperature before the consultation. The results of the survey showed that some knowledge gaps exist among dental students regarding this very deadly disease and hence is an urgent need for training and conduct complete awareness regarding this deadly disease and control it by essential precautionary methods.
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Kennicott, Philip, and Jean McMahon. "The Seduction of Science to Perfect an Imperfect Race." International Journal of Health Services 35, no. 2 (April 2005): 399–404. http://dx.doi.org/10.2190/hmxf-vr7e-cmnw-hr36.
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The author reflects on the lessons of the Holocaust Memorial Museum's exhibition “Deadly Medicine: Creating the Master Race.” The exhibition is about problems universal to science and medicine. Eugenics was not a crazed Hitlerian fantasy, and eugenicists were within the scientific mainstream. To the extent that American science pursues an openness and transparency that was absent from Nazi science, it may insulate itself from ethical dangers. But “Deadly Medicine” diagnoses patterns of thought that persist in science and social thinking. The exhibition reminds us that when faced with fears and anxieties similar to those that led to Auschwitz, we have scientific, historical, legal, and social precedents that can turn us toward an ethical confusion and uncertainty that is healthier than the certainty with which Nazi science proceeded down its grisly road.
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Ross, Hugh. "Black Holes as Evidence of God’s Care." Religions 12, no. 3 (March 18, 2021): 201. http://dx.doi.org/10.3390/rel12030201.
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As black holes gravitationally draw matter toward their event horizons, a high proportion of this matter is converted into energy. Radiation from this conversion process is deadly for advanced life. The apparent incompatibility of black holes with advanced life raises a problem for Christians and other theists who believe that God planned the rise of advanced life on Earth. Yet additional scientific data may help to resolve this apparent problem. This article argues that a universe with the mass and laws and constants of physics to make advanced life possible will inevitably produce black holes, and this is good news. When the most massive stars and merging neutron stars become black holes, they manufacture elements heavier than iron. Eight of these r-process elements appear essential for advanced life; the remainder appear essential for enduring life and for advanced civilization. Moreover, though black holes produce deadly radiation in all known regions of the universe where advanced life is conceivable, our solar system is protected from this deadly radiation. By apparent fine-tuning, we live in a uniquely safe and uniquely provisioned location. These scientific findings suggest a way that theists can reconcile the existence of black holes with the existence of a Creator.
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R. Oquendo, Ángel. "Toward a European citizenship based on transnational constitutionalism and solidarity." UNIO – EU Law Journal 6, no. 1 (July 5, 2020): 3–11. http://dx.doi.org/10.21814/unio.6.1.2702.
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In this text the author argues that the European Union should undertake a twofold strategy to assure its own survival against the deadly threat of ethno-nationalism. In particular, it should (1) propel a participatory procedure to constitutionalize and to transform how it views itself and (2) enhance social-welfare rights for the benefit of the immense majority of its citizens. These initiatives would inevitably have to take place over an extended period of time and against all odds. Notwithstanding, they appear to offer the Continent its only chance of overcoming its longstanding crisis and resisting its ethnic nationalist temptations.
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Jan, Inamullah, and Shabir Hussain. "Media, War and Peace: Towards Peace Journalism Strategies in Pakistan." Global Regional Review V, no. I (March 30, 2020): 340–45. http://dx.doi.org/10.31703/grr.2020(v-i).37.
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In this article, the researchers have examined various factors that affect reporting of two deadly conflicts in Pakistan and identify peace-oriented strategies to help resolve these conflicts. For this purpose, comprehensive and inclusive interviews were conducted with reporters covering the Taliban conflict and the ethno-political conflict in Karachi. The researchers found that the nature of a conflict and threats from conflict stakeholders were the important factors that shape the production of conflict news. As far as peace journalism strategies are concerned, it was found that a more contextual way of reporting alongside humanization those sufferers would facilitate broader understanding and resolution of these conflicts in Pakistan.
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Rao, Naveen. "Turtlegoose Sazerac." World Futures Review 13, no. 2 (June 2021): 131–40. http://dx.doi.org/10.1177/19467567211025764.
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A short story exploring the unthought futures of public health in America, Turtlegoose Sazerac introduces a young trans protagonist, Cayce, who has arrived at a career crossroads following a deadly massacre of a homeless encampment near their home in Oakland, California. Seeking advice from a past mentor, Victor, Cayce faces an uncertain path filled with digital, physical, and metaphysical challenges on their quest toward a career with impact.
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Bibi, Nousheen, Sehraiz Razzaq, Faisal Nouroz, Farhat Amin, Ambreen Shahnaz, and Mohammad Amjad Kamal. "Identification of Putative “Multifunctional Drug” Against Anthrax Toxins via Integrative Computational Approach." Letters in Drug Design & Discovery 17, no. 12 (November 19, 2020): 1516–30. http://dx.doi.org/10.2174/1570180817999200818175544.
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Background: The intentional dissemination of the “anthrax letter” led the researchers to increase their efforts towards the development of medical countermeasures against anthrax bioterrorism. A virulent strain of Bacillus anthracis secretes deadly three protein exotoxin (protective antigen, lethal factor and edema factor) that is the causative agent of anthrax and considered as serious biological weapons. Objective: Due to limited existing therapeutics options, there is still an insecure situation to combat anthrax. This prompted us to design a multifunctional inhibitor instead of a traditional one that competes simultaneously with the Protective Antigen (PA), Lethal Factor (LF) and Edema Factor (EF) for their binding sites. Methods: We integrated a pharmacophore modeling approach with the virtual screening and molecular docking analysis in the context of unique structural characteristics of deadly anthrax toxins. Results: Initially, we screened 56,000 natural compounds against designed pharmacophore consensus that returned 351 hits. Out of these initial screening hits, only 100 compounds passed out through Lipinski filter that comprised of 12 chemically relevant clusters. By exclusion of duplicate and based on their fit score in each cluster, 15 unique compounds were selected for detailed study. Putative multifunctional compounds subjected to deep structural analysis in the milieu of anthrax toxins binding pockets to gauge critical structural crunch. Conclusion: Our integrative approach provides a novel therapeutic window to develop a small molecular inhibitor that simultaneously targets three components of anthrax deadly toxin at the molecular level to elicit the desired biological process.
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Journal, Baghdad Science. "Evaluation of bioactivity against some pathogenic bacteria and oxidation for fungal secondary metabolites of Fusarium solani isolated from soil." Baghdad Science Journal 14, no. 3 (September 3, 2017): 497–502. http://dx.doi.org/10.21123/bsj.14.3.497-502.
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The study included isolate and diagnose fungus Fusarium solani of the local soil and purified and development in the PDB medium and the filtrate extracted using a solvent (Ethyl acetate) to obtain the fungal secondary metabolites extract. This extract has shown bioactivity against both reference isolates (E.coli (ATCC25922) and S.aureus(NCTC6571)) and pathogenic isolates S.pyogenes, K. pneumonia and S.typhimurium using agar disk diffusion technique , The diameters of the inhibition zones of fungal secondary metabolites24.0 mm against E.coli and 31.5 mm against S.aureus,and 34.0 mm against K.pneumoniae and 18.0 mm against S.pyogenes and 33.5mm against S.typhimurium. The test revealed the minimum inhibitory concentration (MIC) of the fungal extract less inhibitor concentration towards our isolation S.aureus was 6.25 µg/ ml also less deadly concentration (MBC).Also against isolate S.aureus was 12.5µg/ ml. also fungal extract showed no toxicity toward human red blood cells. Tested the antioxidant of the fungal extract by measuring its ability to be reduced iron duo ions (Fe ?) have shown high rates of inhibition. The metabolic product of soil fungi can be an alternative source of commercial anti-bacterial.
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Godinho, Patrícia I. C., Raquel G. Soengas, and Vera L. M. Silva. "Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents." Pharmaceuticals 14, no. 6 (June 7, 2021): 546. http://dx.doi.org/10.3390/ph14060546.
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The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread all over the world, creating a devastating socio-economic impact. Even though protective vaccines are starting to be administered, an effective antiviral agent for the prevention and treatment of COVID-19 is not available yet. Moreover, since new and deadly CoVs can emerge at any time with the potential of becoming pandemics, the development of therapeutic agents against potentially deadly CoVs is a research area of much current interest. In the search for anti-coronaviral drugs, researchers soon turned their heads towards glycosylated flavonoids. Glycosyl flavonoids, widespread in the plant kingdom, have received a lot of attention due to their widely recognized antioxidant, anti-inflammatory, neuroprotective, anticarcinogenic, antidiabetic, antimicrobial, and antiviral properties together with their capacity to modulate key cellular functions. The wide range of biological activities displayed by glycosyl flavonoids, along with their low toxicity, make them ideal candidates for drug development. In this review, we examine and discuss the up-to-date developments on glycosyl flavonoids as evidence-based natural sources of antivirals against coronaviruses and their potential role in the management of COVID-19.
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Jadus, Martin R., Josephine Natividad, Anthony Mai, Yi Ouyang, Nils Lambrecht, Sandor Szabo, Lisheng Ge, Neil Hoa, and Maria G. Dacosta-Iyer. "Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention." Clinical and Developmental Immunology 2012 (2012): 1–21. http://dx.doi.org/10.1155/2012/160724.
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Lung cancers remain one of the most common and deadly cancers in the world today (12.5% of newly diagnosed cancers) despite current advances in chemo- and radiation therapies. Often, by the time these tumors are diagnosed, they have already metastasized. These tumors demonstrate the classic hallmarks of cancer in that they have advanced defensive strategies allowing them to escape various standard oncological treatments. Immunotherapy is making inroads towards effectively treating other fatal cancers, such as melanoma, glioblastoma multiforme, and castrate-resistant prostate cancers. This paper will cover the escape mechanisms of bronchogenic lung cancer that must be overcome before they can be successfully treated. We also review the history of immunotherapy directed towards lung cancers.
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Gruber, Judith. "Salvation in a Wounded World. Towards a Spectral Theology of Mission." Mission Studies 37, no. 3 (December 16, 2020): 374–96. http://dx.doi.org/10.1163/15733831-12341737.
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Abstract This article argues that there is a growing discrepancy between theological and critical approaches to mission: while critical mission studies have abandoned teleological frameworks for the narration of mission history, historico-theological teleologies still prove to be influential in theological conceptualizations of mission. As a result, there is a lack of theological language that can respond constructively to the interdisciplinary re-reading of mission history – mission theology is immunized from the interdisciplinary critique of mission history. Based on this diagnosis, this article asks what kind of theological approach can account for the complex entanglements of Christian knowledge production into the deadly politics of modern colonialism. Taking an interdisciplinary approach that intersects theology and postcolonial trauma studies, it investigates the narratives of decolonization that emerged around the recent renovation of the Afrika Museum in Brussels, Belgium, and develops from this analysis building blocks towards a ‘spectral theology.’
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Kim, Eleana J. "Toward an Anthropology of Landmines: Rogue Infrastructure and Military Waste in the Korean DMZ." Cultural Anthropology 31, no. 2 (May 4, 2016): 162–87. http://dx.doi.org/10.14506/ca31.2.02.
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Drawing on research in the borderlands of South Korea near the Korean Demilitarized Zone, this essay analyzes the heterogeneous life of landmines in postconflict militarized ecologies. Humanitarian narratives typically frame mines as deadly remnants of war, which aligns with postcolonial critiques viewing them as traces of imperial power and ongoing violence. Given that landmines and other unexploded ordnance can remain live for up to a hundred years, I suggest that mines and minefields become infrastructural when their distributed agency is redistributed over time, bringing into view nonhuman agencies and affordances that might otherwise go undetected in humanitarian or postcolonial critiques. I offer the framework of rogue infrastructure to capture the volatile materiality of mines and their multiple natural, cultural, technical, and political entanglements with the humans who exist alongside them.
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Bhat, Pragathi R., Pratheek Bolar, and Vijay A. Trasad. "Assessment of degree of willingness to undergo covid test amongst the patients visiting SDM college of dental sciences & hospital, Dharwad." Journal of Dental Panacea 3, no. 2 (August 15, 2021): 58–68. http://dx.doi.org/10.18231/j.jdp.2021.014.
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Severe Acute Respiratory Syndrome Coronavirus-2 or SARS-CoV-2 is a deadly pandemic sickness that is currently affecting throughout the globe and the need of the hour is that people become aware about the contagious disease, and are willing to undergo the Covid-19 test as an when needed. : To assess the degree of willingness to undergo covid test amongst patients visiting SDMCDSH, Dharwad. : A questionnaire with 15 questions pertaining to their willingness to undergo a covid test was assessed in 332 participants. A pre-tested close ended questionnaire comprising of 15 questions were distributed to 332 patients between 18-65 years of age visiting outpatient department of SDMCDSH, Dharwad with questions related to willingness of the participants to undergo COVID-19 test. A Pearson’s Chi Square value using an SPSS software was used to assess the differences in the gender, level of education and occupation of all the subjects. A statistically significant p-value was set as < 0.05. Majority of the study participants had a positive attitude towards covid test and were willing to undergo the test as and when needed thus concluding that most of the patients visiting outpatient department of SDMCDSH, Dharwad were aware about the deadly covid-19 pandemic disease and were willing to undergo a covid test so as to prevent the spread of infection. Majority of the population have a positive attitude towards covid test and are willing to undergo the test if needed so as to prevent the spread of infection.
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Molina-Molina, Maria, Alvar Agusti, Bruno Crestani, David A. Schwartz, Melanie Königshoff, Rachel C. Chambers, Toby M. Maher, et al. "Towards a global initiative for fibrosis treatment (GIFT)." ERJ Open Research 3, no. 4 (October 2017): 00106–2017. http://dx.doi.org/10.1183/23120541.00106-2017.
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Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterised by increased scarring of lung tissue. Despite the recent introduction of novel drugs that slow disease progression, IPF remains a deadly disease, and the benefits of these new drugs differ markedly between patients.Human diseases arise due to alterations in an almost limitless network of interconnected genes, proteins, metabolites, cells and tissues, in direct relationship with a continuously changing macro- or microenvironment. Systems biology is a novel research strategy that seeks to understand the structure and behaviour of the so-called “emergent properties” of complex systems, such as those involved in disease pathogenesis, which are most often overlooked when just one element of disease pathogenesis is observed in isolation.This article summarises the debate that took place during a European Respiratory Society research seminar in Barcelona, Spain on December 15–16, 2016, which focused on how systems biology could generate new data by integrating the different IPF pathogenic levels of complexity. The main conclusion of the seminar was to create a global initiative to improve IPF outcomes by integrating cutting-edge international research that leverages systems biology to develop a precision medicine approach to tackle this devastating disease.
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Filiya, Ana Nur, and Novy Ardyanti Putri. "Correlation Between Direct Contact Status with Diphteria in Blitar." STRADA JURNAL ILMIAH KESEHATAN 8, no. 2 (November 19, 2019): 97–100. http://dx.doi.org/10.30994/sjik.v8i2.185.
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Diphtheria is a contagion deadly disease which case increases year-by-year. Objective: To know the correlation of direct contact with diphteria patient towards diphteria in Blitar in 2016. This research method uses Observational-analytic study by using case control design. Sample in case group were 31 people of diphteria patients and 31 people of control group which is not a diphteria patients. Direct contact as Independent variable. Data were analyzed by Mc Nemar. The results showed p value is 0.21. Direct contact haven’t associated with diphteria. Further research can use more detailed questionnaire to know direct contact status properly
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Telvak, Viktoria. ""DEADLY ENEMY OF THE POLISH PEOPLE": IMAGES OF MYKHAILO HRUSHEVSKY IN POLISH JOURNALISM." Problems of humanities. History, no. 5/47 (March 27, 2021): 294–308. http://dx.doi.org/10.24919/2312-2595.5/47.217813.
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Summary. The purpose of the publication is to clarify the dynamics of assessments of M. Hrushevsky’s socio-political activities in the pages of Polish periodicals of the early twentieth century. The methodological basis is an interdisciplinary approach. Special emphasis is placed on the structural-functional systematic analysis of historiographical facts and the method of critical analysis of documentary material. The scientific novelty of the article lies in the attempt to comprehensively analyse the Polish Hrushevsky studies in terms of the reaction of its representatives to the socio-political initiatives of a prominent Ukrainian historian. Conclusions. The conducted historiographical analysis showed that Polish journalism was unconditionally critical towards M. Hrushevsky’s numerous cultural and public initiatives. None of the scientist’s attempts to gain more rights for Ukrainians in Eastern Galicia were met with sympathy. We would like to note that Polish publicists of all parties united in a consistent denial of the arguments of the Lviv professor. Instead, we can note a clear change in tone in the discussion with M. Hrushevsky. Thus, the balanced critical writings at the turn of the 19th and 20th centuries were replaced in the last pre-war years by the demonstrative profanation of his suggestions for the normalization of Polish-Ukrainian relations. At the same time, the image of the scholar in the pages of Polish periodicals became more and more demonised. All these actions were components of the general ideological attack of Polish intellectuals on modern Ukrainians, that in the last years of the Great War turned into an armed conflict.
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Ariffin, Nur Izzati, Siti Hajar Mohd Badrol, Siti Aida Aliah Mohd Azlan, and Faridah Hussain. "AWARENESS, ATTITUDE AND PRACTICES TOWARDS COVID-19 AMONG IIUM STUDENTS." International Journal of Law, Government and Communication 6, no. 24 (June 15, 2021): 01–17. http://dx.doi.org/10.35631/ijlgc.624001.
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The rise of the COVID-19 pandemic has killed more than two million people within a year. The deadly virus brings chaotic problems to every layer of society, including university students. The main goal of this study is to investigate the awareness regarding COVID-19 among International Islamic University of Malaysia (IIUM) students. This study examines the awareness, perception, and involvement of the IIUM community to mitigate the spread of COVID-19 during the scare. A qualitative research design was employed, using an interview method through purposive sampling procedure as the research instrument used for the data collection. A total of eight respondents, including international and local university students, participated in the study. The study adopted the situational theory of publics by Grunig (1966) to guide the study. This study found that IIUM local students have adequate information and awareness regarding COVID-19. However, future efforts should be aimed at enhancing awareness campaigns among the IIUM international students in Malaysia. The findings of the study will have implications on awareness, perception, and behaviour during a virus outbreak.
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Weitzel, Corinna, Nina Rønsted, Krysztof Spalik, and Henrik Toft Simonsen. "Resurrecting deadly carrots: towards a revision ofThapsia(Apiaceae) based on phylogenetic analysis of nrITS sequences and chemical profiles." Botanical Journal of the Linnean Society 174, no. 4 (March 13, 2014): 620–36. http://dx.doi.org/10.1111/boj.12144.
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Liem, Silva, Rustono Farady Marta, Hana Panggabean, and Clara R. P. Ajisukmo. "Comparative Review Between COVID-19 and Stunting: Communication Framework Toward Risk-Mitigating Behavior." Buletin Psikologi 28, no. 2 (December 22, 2020): 113. http://dx.doi.org/10.22146/buletinpsikologi.59883.
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In addition to COVID-19, stunting is another threat facing Indonesia. Although not as deadly as COVID-19, stunting requires immediate responses; otherwise it will burden our development agenda. Substantial evidences from application of Theory of Planned Behavior (TPB) accumulate significant relationship of health intentions to individuals’ behavior. Further extension of TPB that include other variables confirm the role of knowledge and risk perception in predicting health intentions and behavior. Similarly involve risk factors within public health area, risk communication of COVID-19 seems outperforms that of stunting. Using TPB’s perspective, this review of literature aims to analyze health promotion impacts of these health threats. Result indicates differences in risk communication strategy for COVID – indicated by emerging amateur health promoters – as to stunting. There is a need for intensive collaboration of Psychology and Communication studies in exploring communication strategies to help building health intentions toward performing risk-mitigating behaviors beyond COVID-19 and stunting alone.
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Pandian, Pasumpon. "IDENTIFICATION AND CLASSIFICATION OF CANCER CELLS USING CAPSULE NETWORK WITH PATHOLOGICAL IMAGES." Journal of Artificial Intelligence and Capsule Networks 01, no. 01 (September 18, 2019): 37–44. http://dx.doi.org/10.36548/jaicn.2019.1.005.
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Cancer is a deadly disease that is costing the lives of many people. Over 9.6 million death is reported in 2018 due to cancer. We propose an ideal methodology to identify and classify cancer cells using pathological images with the help of capsule network. Capsule network’s capability to learn patterns based on previous iterations can be exploited for this purpose. This can help in identification of cancer at early stages and work at the root cause of the disease and walk towards completely shutting down the disease. Image processing is done along with fuzzification and further, it is handled with capsule network classifier and analysed.
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Tardieux, Isabelle, and Jake Baum. "Reassessing the mechanics of parasite motility and host-cell invasion." Journal of Cell Biology 214, no. 5 (August 29, 2016): 507–15. http://dx.doi.org/10.1083/jcb.201605100.
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The capacity to migrate is fundamental to multicellular and single-celled life. Apicomplexan parasites, an ancient protozoan clade that includes malaria parasites (Plasmodium) and Toxoplasma, achieve remarkable speeds of directional cell movement. This rapidity is achieved via a divergent actomyosin motor system, housed within a narrow compartment that lies underneath the length of the parasite plasma membrane. How this motor functions at a mechanistic level during motility and host cell invasion is a matter of debate. Here, we integrate old and new insights toward refining the current model for the function of this motor with the aim of revitalizing interest in the mechanics of how these deadly pathogens move.
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Nasta, Mardiyanah, Hasriani G. Hasriani G., and Asriati Asriati. "SYMBOLS OF THE DEATHLY HALLOWS IN J.K. ROWLING’S “HARRY POTTER AND THE DEATHLY HALLOWS”." Jurnal Pendidikan Bahasa dan Sastra 20, no. 1 (June 30, 2020): 29–36. http://dx.doi.org/10.17509/bs_jpbsp.v20i1.25968.
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This research aimed to describe what the Deathly Hallows symbolized in J.K. Rowling’s “Harry Potter and the Deathly Hallows”. This was a qualitative content analysis with hermeneutic approach. The primary data was from the novel of Harry Potter and the Deathly Hallows. The results of this research were the Deathly Hallows symbolized the thirst of the greatest power which could make the owner immortal, but for Harry Potter they symbolized a test, which tested his mission to defeat Voldemort. The Hallows themselves consisted of three objects which were the Elder Wand, the Resurrection Stone, and the Invisibility Cloak. Each of the Hallows also symbolized different things. The Elder Wand symbolized a wizard’s desire for power, the Resurrection Stone symbolized deep longing towards the loved one who had died, and the Invisibility Cloak symbolized protection.
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Mutz, Diana C. "Harry Potter and the Deathly Donald." PS: Political Science & Politics 49, no. 04 (October 2016): 722–29. http://dx.doi.org/10.1017/s1049096516001633.
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ABSTRACTFew empirical studies suggest that fictional stories can influence political opinions. Nonetheless, in this study I demonstrate the relevance of Harry Potter consumption to oppositional attitudes toward Donald Trump and his worldview. Using multivariate observational models and panel data from 2014 to 2016, results suggest that the lessons of the Harry Potter series have influenced levels of opposition to punitive policies and support for tolerance of groups considered outside the American mainstream. Further, they predict public reactions to Donald Trump above and beyond their influence on policies consistent with his views.
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Jurisicova, Andrea, and Beth M. Acton. "Deadly decisions: the role of genes regulating programmed cell death in human preimplantation embryo development." Reproduction 128, no. 3 (September 2004): 281–91. http://dx.doi.org/10.1530/rep.1.00241.
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Human preimplantation embryo development is prone to high rates of early embryo wastage, particularly under currentin vitroculture conditions. There are many possible underlying causes for embryo demise, including DNA damage, poor embryo metabolism and the effect of suboptimal culture media, all of which could result in an imbalance in gene expression and the failed execution of basic embryonic decisions. In view of the complex interactions involved in embryo development, a thorough understanding of these parameters is essential to improving embryo quality. An increasing body of evidence indicates that cell fate (i.e. survival/differentiation or death) is determined by the outcome of specific intracellular interactions between pro- and anti-apoptotic proteins, many of which are expressed during oocyte and preimplantation embryo development. The recent availability of mutant mice lacking expression of various genes involved in the regulation of cell survival has enabled rapid progress towards identifying those molecules that are functionally important for normal oocyte and preimplantation embryo development. In this review we will discuss the current understanding of the regulation of cell death gene expression during preimplantation embryo development, with a focus on human embryology and a discussion of animal models where appropriate.
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Nurahmi, Leni, and Rita Damayanti. "Respon Perokok Remaja Terhadap Peringatan Kesehatan Bergambar di Bungkus Rokok." Perilaku dan Promosi Kesehatan: Indonesian Journal of Health Promotion and Behavior 1, no. 1 (April 10, 2018): 63. http://dx.doi.org/10.47034/ppk.v1i1.2119.
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Background. Smoking is a risk of chronic and deadly diseases in the world. In 2014, 80% of 5.8 billion smokers in the world started smoking at 17.6 years old. Pictorial health warning on cigarette pack was implemented since 24 June 2014 in Indonesia to protect teenagers from smoking. Objective. This study aimed to assess teenage smokers’ responses toward pictorial health warning on cigarette pack in Depok City. Method. This cross-sectional study used a questionnaire from the Center for Health Research Universitas Indoonesia. Result. We found differences in fear, severity, response efficacy and intention. We found no differences in susceptibility, self efficacy, acceptance and ignorance to pictorial health warning. Keyword: pictorial health warning, fear appeal, teenage smoker.
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G. Koomson, James. "Analysis of Covid-19 in the United States using Machine Learning." Machine Learning and Applications: An International Journal 8, no. 1 (March 31, 2021): 15–21. http://dx.doi.org/10.5121/mlaij.2021.8102.
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The unprecedented outbreak of COVID-19 also known as the coronavirus has caused a pandemic like none ever seen before this century. Its impact has been massive on a global level. The deadly virus has commanded nations around the world to increase their efforts to fight against the spread of the virus after the stress it has put on resources. With the number of new cases increasing day by day around the world, the objective of this paper is to contribute towards the analysis of the virus by leveraging machine learning models to understand its behavior and predict future patterns in the United States (US) based on data obtained from the COVID-19 Tracking Project.
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Lenka, Purnima, and Sarita Kar. "Transformational Leadership: An Approach of Business Sustainability during the COVID-19 Pandemic with Special Reflection to India." Problemy Ekorozwoju 16, no. 2 (July 1, 2021): 41–50. http://dx.doi.org/10.35784/pe.2021.2.05.
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The whole world is in the crisis of monumental proportions because of the effects of COVID 19. It is the most deadly pandemic not only in India but globally. The cost of the pandemic as concerning the loss of human lives is painful, but the effects on the global economy and the prospects for sustainable development are also worrying. How to sustain the business organization in this time of pandemic is one of the most crucial questions raised in this time. The present paper investigates the role of business leaders in this time of COVID 19 and their concerns towards business sustainability with special reflection to Indian business organisations. This paper basically deals with two questions the first one is what is COVID 19 and its effects, the second one is the role of transformational leaders towards business sustainability in this time of the pandemic.
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FERGUSON, DUNCAN STUART. "“Splendid allies” or “No more deadly enemies in the world?” General Sir Ian Hamilton, the British Military and Japan 1902–1914." Journal of the Royal Asiatic Society 20, no. 4 (October 2010): 523–36. http://dx.doi.org/10.1017/s1356186310000271.
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AbstractThis article uses archival material, including personal correspondence, to chart General Sir Ian Hamilton's changing attitudes towards Japanese nationals, Japanese military leaders and Japanese military personnel, during and after the Russo Japanese War.
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Goyal, Akash, A. N. Shankar, and S. K. Sethy. "Parametric Analysis of Hyperbolic Cooling Tower under Seismic Loads, Wind Loads and Dead Load through Staad. Pro." International Journal of Engineering Research and Science 3, no. 8 (August 31, 2017): 38–41. http://dx.doi.org/10.25125/engineering-journal-ijoer-aug-2017-6.
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Gabriel, Joseph M. "Restricting the Sale of “Deadly Poisons”: Pharmacists, Drug Regulation, and Narratives of Suffering in the Gilded Age." Journal of the Gilded Age and Progressive Era 9, no. 3 (July 2010): 313–36. http://dx.doi.org/10.1017/s1537781400004084.
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This article examines the origins of state-level regulations controlling the practice of pharmacy and the manufacture and consumption of dangerous drugs in the Gilded Age. The passage of laws regulating the market in pharmaceuticals grew out of both the precarious economic position of practicing pharmacists and widespread concern for the suffering of individual consumers. As a result, pharmacy laws and other regulations controlling the buying, selling, and use of dangerous drugs during this period should be understood as part of the effort by pharmacists to establish a professional identity for themselves. At the same time, these laws should also be understood as part of the process through which reformers sought to rationalize society toward the goal of protecting the individual consumer. Ironically, however, such efforts were intertwined with the bifurcation of consumer culture into legitimate and illegitimate realms, and with it the creation of the economic and social conditions in which new stories of individual suffering took place.
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Mondal, Arijit, Sankhadip Bose, Sabyasachi Banerjee, Jayanta Kumar Patra, Jai Malik, Sudip Kumar Mandal, Kaitlyn L. Kilpatrick, et al. "Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs." Marine Drugs 18, no. 9 (September 19, 2020): 476. http://dx.doi.org/10.3390/md18090476.
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Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer research have focused on natural medicinal products. Over the past decades, a great deal of initiatives was invested towards isolating and identifying new marine metabolites via pharmaceutical companies, and research institutions in general. Secondary marine metabolites are looked at as a favorable source of potentially new pharmaceutically active compounds, having a vast structural diversity and diverse biological activities; therefore, this is an astonishing source of potentially new anticancer therapy. This review contains an extensive critical discussion on the potential of marine microbial compounds and marine microalgae metabolites as anticancer drugs, highlighting their chemical structure and exploring the underlying mechanisms of action. Current limitation, challenges, and future research pathways were also presented.
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Mazumder, Tarikul, Sayantan Nath, Nibendu Nath, and Munish Kumar. "Head and Neck Squamous Cell Carcinoma: Prognosis using molecular approach." Open Life Sciences 9, no. 6 (June 1, 2014): 593–613. http://dx.doi.org/10.2478/s11535-014-0292-3.
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AbstractHead and neck squamous cell carcinoma (HNSCC) is the fifth most prevalent cancer worldwide. Apart from various known clinicopathogical factors, it is still a major concern as many genetic and epigenetic alterations bring about the possibility of this deadly disease. The aim of this review is to explore the possible role of DNA repair pathways and the polymorphic status of DNA repair genes (XPA, XPC, XPD, XRCC1 and XRCC3) in the onset of HNSCC, along with sequence variations in genes such as Glutathione S-transferases (GSTT1, M1 and P1) that are significantly associated with HNSCC risk. We also focus on the p53 gene mutation induced by various etiological agents and threat factors with its implications towards HNSCC, and emphasise the current therapeutic interventions in treating HNSCC.
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Swaney, Philip J., Arthur W. Mahoney, Bryan I. Hartley, Andria A. Remirez, Erik Lamers, Richard H. Feins, Ron Alterovitz, and Robert J. Webster. "Toward Transoral Peripheral Lung Access: Combining Continuum Robots and Steerable Needles." Journal of Medical Robotics Research 02, no. 01 (February 26, 2017): 1750001. http://dx.doi.org/10.1142/s2424905x17500015.
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Lung cancer is the most deadly form of cancer in part because of the challenges associated with accessing nodules for diagnosis and therapy. Transoral access is preferred to percutaneous access since it has a lower risk of lung collapse, yet many sites are currently unreachable transorally due to limitations with current bronchoscopic instruments. Toward this end, we present a new robotic system for image-guided trans-bronchoscopic lung access. The system uses a bronchoscope to navigate in the airway and bronchial tubes to a site near the desired target, a concentric tube robot to move through the bronchial wall and aim at the target, and a bevel-tip steerable needle with magnetic tracking to maneuver through lung tissue to the target under closed-loop control. In this work, we illustrate the workflow of our system and show accurate targeting in phantom experiments. Ex vivo porcine lung experiments show that our steerable needle can be tuned to achieve appreciable curvature in lung tissue. Lastly, we present targeting results with our system using two scenarios based on patient cases. In these experiments, phantoms were created from patient-specific computed tomography information and our system was used to target the locations of suspicious nodules, illustrating the ability of our system to reach sites that are traditionally inaccessible transorally.
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Graffeo, Christopher S., Avital Perry, Ross C. Puffer, Lucas P. Carlstrom, Wendy Chang, Grant W. Mallory, and Michelle J. Clarke. "Deadly falls: operative versus nonoperative management of Type II odontoid process fracture in octogenarians." Journal of Neurosurgery: Spine 26, no. 1 (January 2017): 4–9. http://dx.doi.org/10.3171/2016.3.spine151202.
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OBJECTIVE Type II odontoid fracture is a common injury among elderly patients, particularly given their predisposition toward low-energy falls. Previous studies have demonstrated a survival advantage following early surgery among patients older than 65 years, yet octogenarians represent a medically distinct and rapidly growing population. The authors compared operative and nonoperative management in patients older than 79 years. METHODS A single-center prospectively maintained trauma database was reviewed using ICD-9 codes to identify octogenarians with C-2 cervical fractures between 1998 and 2014. Cervical CT images were independently reviewed by blinded neurosurgeons to confirm a Type II fracture pattern. Prospectively recorded outcomes included Glasgow Coma Scale (GCS) score, Abbreviated Injury Scale (AIS) score, Injury Severity Score (ISS), additional cervical fracture, and cord injury. Primary end points were mortality at 30 days and at 1 year. Statistical tests included the Student t-test, chi-square test, Fisher's exact test, Kaplan-Meier test, and Cox proportional hazard. RESULTS A total of 111 patients met inclusion criteria (94 nonoperative and 17 operative [15 posterior and 2 anterior]). Mortality data were available for 100% of patients. The mean age was 87 years (range 80–104 years). Additional cervical fracture, spinal cord injury, GCS score, AIS score, and ISS were not associated with either management strategy at the time of presentation. The mean time to death or last follow-up was 22 months (range 0–129 months) and was nonsignificant between operative and nonoperative groups (p = 0.3). Overall mortality was 13% in-hospital, 26% at 30 days, and 41% at 1 year. Nonoperative and operative mortality rates were not significant at any time point (12% vs 18%, p = 0.5 [in-hospital]; 27% vs 24%, p = 0.8 [30-day]; and 41% vs 41%, p = 1.0 [1-year]). Kaplan-Meier analysis did not demonstrate a survival advantage for either management strategy. Spinal cord injury, GCS score, AIS score, and ISS were significantly associated with 30-day and 1-year mortality; however, Cox modeling was not significant for any variable. Additional cervical fracture was not associated with increased mortality. The rate of nonhome disposition was not significant between the groups. CONCLUSIONS Type II odontoid fracture is associated with high morbidity among octogenarians, with 41% 1-year mortality independent of intervention—a dramatic decrease from actuarial survival rates for all 80-, 90-, and 100-year-old Americans. Poor outcome is associated with spinal cord injury, GCS score, AIS score, and ISS.
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Jain, Keerti, Anand S. Patel, Vishwas P. Pardhi, and Swaran Jeet Singh Flora. "Nanotechnology in Wastewater Management: A New Paradigm Towards Wastewater Treatment." Molecules 26, no. 6 (March 23, 2021): 1797. http://dx.doi.org/10.3390/molecules26061797.
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Clean and safe water is a fundamental human need for multi-faceted development of society and a thriving economy. Brisk rises in populations, expanding industrialization, urbanization and extensive agriculture practices have resulted in the generation of wastewater which have not only made the water dirty or polluted, but also deadly. Millions of people die every year due to diseases communicated through consumption of water contaminated by deleterious pathogens. Although various methods for wastewater treatment have been explored in the last few decades but their use is restrained by many limitations including use of chemicals, formation of disinfection by-products (DBPs), time consumption and expensiveness. Nanotechnology, manipulation of matter at a molecular or an atomic level to craft new structures, devices and systems having superior electronic, optical, magnetic, conductive and mechanical properties, is emerging as a promising technology, which has demonstrated remarkable feats in various fields including wastewater treatment. Nanomaterials encompass a high surface to volume ratio, a high sensitivity and reactivity, a high adsorption capacity, and ease of functionalization which makes them suitable for application in wastewater treatment. In this article we have reviewed the techniques being developed for wastewater treatment using nanotechnology based on adsorption and biosorption, nanofiltration, photocatalysis, disinfection and sensing technology. Furthermore, this review also highlights the fate of the nanomaterials in wastewater treatment as well as risks associated with their use.
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Grove, Hugh, and James C. Lockhart. "Evolution of corporate governance towards intrinsic value." Corporate Law and Governance Review 1, no. 1 (March 21, 2019): 8–15. http://dx.doi.org/10.22495/clgrv1i1p1.
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The major research question addressed by this paper is how to evolve corporate governance beyond its traditional shareholder focus towards the broader perspective of a stakeholder focus with intrinsic value. Intrinsic value refers to the monetary value of a company, stock, currency, or product determined by fundamental analysis, without reference to extant market value. It is ordinarily calculated by summing the discounted future income generated by the company, stock, currency or product to obtain its present value. In this paper we observe the evolution of corporate governance towards an intrinsic, long-term value focus by the boards of directors, corporate executives, owners and shareholders, regulators and legislators, and other stakeholders. These major players are encouraged to develop more wisdom in order to assess the emerging threats, challenges, and opportunities from technology for intrinsic value, especially with the perspective of the public corporation as a separate legal personhood, as advocated by the European Parliament’s Committee on Legal Affairs in 2015. The rapid increase in the development of artificial intelligence (AI) and other technologies has tremendous significance for these major players broadly contributing to effective corporate governance. To facilitate the development and evolution of intrinsic value for public corporations and other entities, these major players need wisdom for more effective corporate governance in challenging times. Accordingly, this paper discusses the evolution of corporate governance and board members’ perspectives from a shareholder focus to a stakeholder focus with intrinsic value; the key success factor being wisdom for boards; the three-dimensional wisdom scale; and, the AI challenge, including the “Deadly Soul” of a new machine, to the wisdom of company executives and their boards of directors.
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Casafús, Milena Gisela, Marília Melo Favalesso, Micaela Andrea Gritti, Juan Manuel Coronel, Ana Tereza Bittencourt Guimarães, and Maria Elisa Peichoto. "A hidden deadly venomous insect: First eco-epidemiological assessment and risk mapping of lonomism in Argentina." PLOS Neglected Tropical Diseases 15, no. 7 (July 1, 2021): e0009542. http://dx.doi.org/10.1371/journal.pntd.0009542.
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Background Envenomation by the South American Lonomia saturniid caterpillars, named lonomism, constitutes an emerging and somewhat neglected public health issue in Argentina and neighboring countries. Considering that there is an intricate relationship between environment and human health in such cases, this study aimed to analyze the eco-epidemiological profile of 40 accidents and 33 occurrences of Lonomia spp. in Misiones (Argentina) between January 2014 and May 2020. Methodology/Principal findings We described the eco-epidemiological variables and characterized the abiotic scenario of such cases. Additionally, we obtained a density map that shows the punctual intensity of Lonomia records throughout Misiones. Most of the accidents occurred in the Department of Guaraní and involved male victims younger than 20 years old. The accidental/occasional occurrence of Lonomia spp. (considering both adult and caterpillar stages together) was significantly higher in the rural area, whereas only adult specimens were found in urban areas. We determined that the presence of this insect in Misiones is positively related to higher temperatures and solar radiation, and larger precipitation and evapotranspiration throughout the year. Conclusion/Significance This study represents an initial step towards the global understanding of lonomism as a public health problem in Argentina. It provides a map of the risk level for this envenomation in Misiones, which could help authorities address public health policy efforts to implement sustainable strategies for prevention and response to this threat in Northeastern Argentina and neighboring regions.
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Baid, Rashmi, and Rakesh Agarwal. "Zika virus and its clinical implications: a comprehensive review." International Journal of Research in Medical Sciences 5, no. 4 (March 28, 2017): 1161. http://dx.doi.org/10.18203/2320-6012.ijrms20171219.
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Recent Zika virus outbreak in Latin America and the Caribbean has drawn the world’s attention toward this relatively unknown virus, with WHO declaring it a public health emergency of international concern (PHEIC). India has had its own tryst with Zika virus with that “significant numbers” of Indians had already been exposed to Zika as early as 1950s. An exponential spread of Zika virus is a potential public health concern, with implications requiring immediate action. The devastating complications of Zika virus infection, particularly congenital and neurological, makes imperative a thorough, thoughtful, and level-headed public health approach in dealing with this infection especially during pregnancy. We review the data on this deadly infection in this brief review including its history, epidemiology, clinical features and management aspects particularly in pregnant women.
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S, Alex David, K. Antony Kumar, and S. Ravi Kumar. "Vision-based Vehicle Detection Survey." International Journal of Recent Contributions from Engineering, Science & IT (iJES) 4, no. 1 (March 29, 2016): 31. http://dx.doi.org/10.3991/ijes.v4i1.5590.
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Nowadays thousands of drivers and passengers were losing their lives every year on road accident, due to deadly crashes between more than one vehicle. There are number of many research focuses were dedicated to the development of intellectual driver assistance systems and autonomous vehicles over the past decade, which reduces the danger by monitoring the on-road environment. In particular, researchers attracted towards the on-road detection of vehicles in recent years. Different parameters have been analyzed in this paper which includes camera placement and the various applications of monocular vehicle detection, common features and common classification methods, motion- based approaches and nighttime vehicle detection and monocular pose estimation. Previous works on the vehicle detection listed based on camera poisons, feature based detection and motion based detection works and night time detection.
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Reich, Björn. "Tanzen gegen die Sünde? Zum Tanzkapitel in Meister Ingolds ‚Guldin Spil‘." Das Mittelalter 23, no. 2 (November 6, 2018): 409–26. http://dx.doi.org/10.1515/mial-2018-0021.
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AbstractIn the 15th century, play and dance were expressively criticised. This makes it all the more remarkable for the Dominican Meister Ingold to identify, in his ‘Guldin Spil’, not only chess, cards and dice as some of the seven games useful to overcome the seven deadly sins, but also dance. Ingold, however, does not praise the outward dance. Rather, he intends to turn the reader towards what may be called inner contemplation or Betrachtung, with the various stages of Jesus’ life are transformed into dance steps. The result is an odd conflict: external dance may have negative connotations, yet lays the mental groundwork for the inner Betrachtung. This article aims to explore this area of conflict by examining the various traditions of interpretation which may have influenced Ingold.
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Peneva, Pavlina A. "Novel Coronavirus – a Challenge in Diagnosing and Timely Treatment, and its Impact on Population Health Status." Folia Medica 63, no. 3 (June 30, 2021): 315–20. http://dx.doi.org/10.3897/folmed.63.e56228.
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In 2019, the world faced another of the potentially deadly viruses affecting humanity. The new virus, COVID-19, was extremely virulent when it first appeared, with aggressive behaviour toward people unprepared at the time to deal with the infection.Months later, we already know much about its pathophysiology, but new and unknown pathophysiological aspects of the disease are revealed in time. The clinical picture is not unequivocal at times, with symptoms quite unlike those we have previously considered normal in respiratory infections tending to appear. There have been reports of an increase in the frequency of neoplasms or disease progression due to delayed treatment. Treatment of COVID-19 is still a mirage, and people are struggling with the implications for recovery, the health and economic crisis, and the psychological effects of traumatic stress.
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Ishfaq, Romah, Anam Zulfiqar, Atif Zulfiqar, Asghar Javaid, Muhammad Zulfiqar, and Naeem Akhtar. "Why Severity Rate of COVID-19 is High in Patients with Diabetes Mellitus: A Brief Insight." BioMedica 36, no. 2S (June 24, 2020): 137–41. http://dx.doi.org/10.51441/biomedica//biomedica/5-447.
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<p>Novel Coronavirus disease 2019 (nCOVID-19) a global pandemic is an ever-remaining threat for patients with Diabetic Mellites (DM). Herein, we have tried to provide brief insight to critically analyze the reasons causing the severity of Coronavirus disease (COVID-19) in patients diagnosed with DM. This, mini review highlights the key investigations starting from binding of COVID-19 at the cellular surface to create sever infection or even death in DM patients. The study further suggested to pay urgent attention towards stabilization of deadly immune response arises as a result of COVID-19. We hope the highlighted investigation will help the researchers to understand and develop a road map to deal DM patients infected with COVID-19 to minimize the severity rate.</p>
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Nedyalkova, Miroslava, and Vasil Simeonov. "Partitioning Pattern of Natural Products Based on Molecular Properties Descriptors Representing Drug-Likeness." Symmetry 13, no. 4 (March 26, 2021): 546. http://dx.doi.org/10.3390/sym13040546.
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A cheminformatics procedure for a partitioning model based on 135 natural compounds including Flavonoids, Saponins, Alkaloids, Terpenes and Triterpenes with drug-like features based on a descriptors pool was developed. The knowledge about the applicability of natural products as a unique source for the development of new candidates towards deadly infectious disease is a contemporary challenge for drug discovery. We propose a partitioning scheme for unveiling drug-likeness candidates with properties that are important for a prompt and efficient drug discovery process. In the present study, the vantage point is about the matching of descriptors to build the partitioning model applied to natural compounds with diversity in structures and complexity of action towards the severe diseases, as the actual SARS-CoV-2 virus. In the times of the de novo design techniques, such tools based on a chemometric and symmetrical effect by the implied descriptors represent another noticeable sign for the power and level of the descriptors applicability in drug discovery in establishing activity and target prediction pipeline for unknown drugs properties.
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Lee, Grace Chee-Yao, Shirly Siew-Ling Wong, and Chin-Hong Puah. "Take the Initiative, Stop Being Passive to NCDs: A PCA-Weighted Composite Indicator towards Prevalence of NCDs in Malaysia." Business and Economic Research 11, no. 3 (June 16, 2021): 35. http://dx.doi.org/10.5296/ber.v11i3.18647.
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In today’s highly dynamic socio-economic environment, the high degree of non-communicable diseases (NCDs) poses both direct and indirect health problems for nations. This study constructed a composite Non-Communicable Diseases Risk Indicator (NCDRI) that comprises leading characteristics to predict the movement of NCDs’ prevalence, which serves as an early signaling tool for policymakers and public health sectors. A weighting scheme for both non-weighted and principal component analysis (PCA)-weighted was applied from the PCA loading factor. The findings verified that the constructed PCA-weighted approach had a remarkable lead time, which also produced better lead times and was consistent in predicting the direction of change in the fluctuations caused by NCDs’ prevalence. An appropriate regime for policymaking and implementation is required, followed by periodic monitoring and rapid action, to reduce the deadly diseases. The findings of this study demonstrate that the cost indicator marked the most significant risk factor to indicate the prevalence of NCDs; therefore, policymakers should converge on this indicator so that cost-effective interventions can result in more valuable outcomes.
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Harries, Byron. "‘Strange Meeting’: Diomedes and Glaucus in Iliad 6." Greece and Rome 40, no. 2 (October 1993): 133–46. http://dx.doi.org/10.1017/s0017383500022749.
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Two men meet on a battlefield; it is getting late, towards the close of a long day's fighting, the first since Achilles deserted the Greeks. The catalogue of this day's deadly confrontations, which has filled much of Books 4 and 5, looks as if it is about to get another victim's name appended to it. Homer introduces the episode at 6.120 by setting the scene as if for a duel, but ends it not only without a fight but with what appears to be a reconciliation, when they finally (6.232) leave their chariots to shake hands. This, if nothing else, has made the meeting of Glaucus and Diomedes famous; with its amiable, irenic outcome, and its unique emphasis on mutual understanding, the scene is widely regarded as an oasis of common decency amid the war-ethos of the surrounding books.
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Lam, Han Yuen, Swee Keong Yeap, Mehdi Rasoli, Abdul Rahman Omar, Khatijah Yusoff, Abd Aziz Suraini, and Noorjahan Banu Alitheen. "Safety and Clinical Usage of Newcastle Disease Virus in Cancer Therapy." Journal of Biomedicine and Biotechnology 2011 (2011): 1–13. http://dx.doi.org/10.1155/2011/718710.
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Newcastle disease virus (NDV) is an avian virus that causes deadly infection to over 250 species of birds, including domestic and wild-type, thus resulting in substantial losses to the poultry industry worldwide. Many reports have demonstrated the oncolytic effect of NDV towards human tumor cells. The interesting aspect of NDV is its ability to selectively replicate in cancer cells. Some of the studies have undergone human clinical trials, and favorable results were obtained. Therefore, NDV strains can be the potential therapeutic agent in cancer therapy. However, investigation on the therapeutic perspectives of NDV, especially human immunological effects, is still ongoing. This paper provides an overview of the current studies on the cytotoxic and anticancer effect of NDV via direct oncolysis effects or immune stimulation. Safety of NDV strains applied for cancer immunotherapy is also discussed in this paper.