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Journal articles on the topic 'Decongestant Formulation'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Shilpa Aher, Shilpa Aher, Prajakta Musmade Prajakta Musmade, Dipali Pulate Dipali Pulate, and Suraj M. Gholap Suraj M Gholap. "Formulation And Evaluation of Nasal Decongestant Vapourizer." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 850–58. https://doi.org/10.35629/4494-1003850858.

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The main focus of this study is to formulate and evaluate nasal decongestant vaporizer using natural components such as Mentha, Ajwain, Tulsi, and Camphor for the treatment of allergic rhinitis and nasal congestion. Camphor and Mentha work together to alleviate congestion in the nasal passages and alleviate allergy symptoms. To address the increasing demand for natural medicines with fewer side effects, the study emphasizes the growing importance of incorporating medicinal plant elements into modern pharmaceutical dosage forms. In conclusion, nasal congestion provides a reliable, practical, an

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2

Samir, Bhargava, and Sharma Atul. "Contemporary Use Of Topical Decongestants: An Indian Perspective." International Journal Of Health & Medical Research 02, no. 08 (2023): 226–30. https://doi.org/10.5281/zenodo.8276301.

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Background: Allergic rhinitis and sinusitis are commonly encountered in primary practice, and nasal congestion is a common symptom experienced by these patients. Thus, it is important to address nasal congestion when treating these conditions. Despite the availability of several treatment options, therapy is impacted by adverse effects and patient dissatisfaction. We conducted a survey to evaluate the prescribing practices of physicians treating allergic rhinitis and sinusitis, with a focus on the formulation of topical xylometazoline with moisturizers (hypromellose and sorbitol). Methods: We

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3

Nadzri, Ainol Hayah Ahmad, Dzulkiflee Ismail, Saravana Kumar Jayaram, Noor Zuhartini Md Muslim, and Wan Nur Syuhaila Mat Desa. "Precursor Profiling of Extracted Pseudoephedrine Using Gas Chromatography-Mass Spectrometry (GCMS) in Conjunction with Chemometric Procedure." Materials Science Forum 1025 (March 2021): 209–18. http://dx.doi.org/10.4028/www.scientific.net/msf.1025.209.

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Various methods for the clandestine manufacture of amphetamine-type stimulant (ATS) involve the extraction and subsequent reaction of pseudoephedrine salts with other essential chemicals. The precursor seized in clandestine laboratory operation is supplied from illegal sources or clandestinely extracted from decongestant tablets (despite the presence of excipients that serve to hamper re-extraction). This work reports the organic profiling of pseudoephedrine from a simulated clandestine extract of different decongestant tablets formulations. The study aims to determine the feasibility of the c

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4

Khan, Farida Habib, Abdullah D. Alotaibi, Amal Daher Alshammari, et al. "Assessment of the Prevalence of the Use of Nasal Decongestants Among Hail Population." Journal of Pharmacy and Bioallied Sciences 17, Suppl 2 (2025): S1770—S1772. https://doi.org/10.4103/jpbs.jpbs_364_25.

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ABSTRACT Background: Nasal decongestants are widely used to relieve nasal congestion caused by conditions such as allergic rhinitis, sinusitis, and the common cold. These medications function by constricting nasal blood vessels, reducing swelling, and improving airflow. Despite their effectiveness, improper use can result in adverse effects, including rebound congestion and cardiovascular complications. Materials and Methods: A cross-sectional study was conducted among 300 adult residents of Hail, Saudi Arabia, using a structured questionnaire. Participants were selected through simple random

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5

Anjali, S. Krishna*. "Formulation And Evaluation of Sodium Alginate Beads Containing Menthol and Camphor for Nasal Congestion Relief." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3711–21. https://doi.org/10.5281/zenodo.15486717.

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Nasal congestion is a common symptom associated with various respiratory conditions, significantly impacting quality of life. This study aims to develop a novel delivery system for nasal congestion relief using sodium alginate beads containing a eutectic mixture of menthol and camphor. The beads were prepared using ionic gelation, a simple and efficient method. The combination of menthol and camphor, known for their decongestant properties, is expected to provide effective relief from nasal congestion. The use of sodium alginate as a natural polymer offers a biocompatible and biodegradable mat

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6

Bratko, G. V., D. D. Dmitriev, V. I. Bratko, A. N. Trunov, and V. V. Chernykh. "Optical neuropathy and edematous exophthalmos. New approaches to treatment." Modern technologies in ophtalmology, no. 3 (July 15, 2021): 301–5. http://dx.doi.org/10.25276/2312-4911-2021-3-301-305.

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Purpose. To study the clinical effectiveness of the administration of complex therapy of drugs to the hemolymphocirculatory organ (pterygopalatine fossa) in edematous exophthalmos in patients with endocrine ophthalmopathy complicated by optical neuropathy. Material and methods. The analysis of the results of treatment of 31 patients (62 eyes) with edematous exophthalmos on the background of endocrine ophthalmopathy complicated by optical neuropathy, who applied for help in the Novosibirsk branch of "MNTC "Eye Microsurgery". All patients were prescribed a 10-day course of intensive complex trea

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7

Bratko, G. V., D. D. Dmitriev, V. I. Bratko, A. N. Trunov, and V. V. Chernykh. "Clinical and diagnostic evaluation of the effectiveness of treatment of optic neuropathy in patients with edematous endocrine ophthalmopathy." Acta Biomedica Scientifica 7, no. 1 (2022): 67–73. http://dx.doi.org/10.29413/abs.2022-7.1.8.

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The aim: to conduct a clinical and diagnostic evaluation of the effectiveness of the administration of a complex of drugs in the region of hemolymphocirculation in optical neuropathy in patients with edematous form of endocrine ophthalmopathy.Materials and methods. The results of diagnosis and treatment of 31 patients (61 eyes) with optical neuropathy on the background of edematous exophthalmos in endocrine ophthalmopathy were analyzed. To identify hidden forms of optical neuropathy, such studies were prescribed as computer microperimetry on a confocal infrared ophthalmoscope, a complex of ele

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8

Bhadury, A., U. K. Roy, T. Ghosh, D. Barman, and P. Mandal. "Assessment of Prescribing Pattern and Safety Profile of Drugs Used in Intranasal Route in Paediatric Age Group of Patients in a Tertiary Care Hospital." Kathmandu University Medical Journal 19, no. 1 (2021): 62–68. http://dx.doi.org/10.3126/kumj.v19i1.49540.

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Background Recently there has been an increased preference for intranasal delivery of drugs due to highly vascular nasal mucosa, bypassing first pass metabolism and the blood brain barrier (BBB) lead in quick drug absorption to the systemic circulation and direct access to brain from olfactory region. For pediatric patients this route offers significant benefits over injections or oral routes, like increased compliance, easy administration, and minimal side effects. Objective Assessment of prescription pattern of drugs and safety profile of drugs used by intranasal route in paediatric ag

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9

Hoffmann, T. J., R. D. Thompson, and J. R. Seifert. "Determination of the Nasal Decongestant, Oxymetazoline Hydrochloride, in Pharmaceutical Formulations by Hplc." Drug Development and Industrial Pharmacy 15, no. 5 (1989): 743–57. http://dx.doi.org/10.3109/03639048909058529.

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10

Johansson, C. J., T. Carlson, P. Olsson, and M. Bende. "Efficacy of a Topical Nasal Decongestant in Different Formulations: the Effect of Viscosity." Acta Oto-Laryngologica 112, no. 6 (1992): 1032–37. http://dx.doi.org/10.3109/00016489209137506.

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11

L. Hamed, Shahad, and Bushra B. Qassim. "New Green Modalities of Flow Injection Technology for Assaying Anti-Allergic Drugs in Pharmaceutics and Biological Samples." Ibn AL-Haitham Journal For Pure and Applied Sciences 36, no. 4 (2023): 288–302. http://dx.doi.org/10.30526/36.4.3115.

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A new approach and the developed FIA technique with many advantages (economic, fast, simple, accurate, and high throughput) are used to determine the decongestant drugs (Phenylephrine.HCl, Oxymetazoline.HCl) in biological samples, pharmaceutical formulations, and pure samples via continuous flow injection technique by oxidative coupling reaction, where the method depends on the interaction of the decongestant drug with organic reagents to produce colored compounds, where Phenylephrine reacts with 4-AAP at λmax503 nm to produce a red compound, and the Beer’s law range of 10-600 μg.mL-1 . As for

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12

Su, X. Y., and A. Li Wan Po. "The effect of some commercially available antihistamine and decongestant intra–nasal formulations on ciliary beat frequency." Journal of Clinical Pharmacy and Therapeutics 18, no. 3 (1993): 219–22. http://dx.doi.org/10.1111/j.1365-2710.1993.tb00617.x.

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13

Sathish Kumar B., Rohan A., and Naveen Gowda B. "Analysis of fixed dose combinations of expectorants, antitussives, decongestants, antihistamines and mucolytics available in the Indian market for rationality and cost variation." International Journal of Basic & Clinical Pharmacology 12, no. 3 (2023): 422–26. http://dx.doi.org/10.18203/2319-2003.ijbcp20231122.

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Background: Aim of the current study was to analyze the FDCs of expectorants, antitussives, decongestants, antihistamines and mucolytics available in the Indian market for their rationality, cost, and dosage forms. Methods: FDCs involving expectorants, antitussives, decongestants, antihistamines and mucolytics listed on Drug Today and Jan Aushadhi online portal were analysed for rationality according to the list of banned FDCs by CDSCO published on 01 Jan 2018. The FDCs with EADAM available in Jan Aushadhi online portal are compared with cost of different brands with same composition, strength

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14

Brock, Michael H., Richard J. Dansereau, and Vikram S. Patel. "Use of In Vitro and In Vivo Data in the Design, Development, and Quality Control of Sustained‐Release Decongestant Dosage Forms." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 14, no. 4 (1994): 430–37. http://dx.doi.org/10.1002/j.1875-9114.1994.tb02833.x.

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Study Objectives. To investigate the use of in vitro and in vivo data in the development of a sustained‐release, carbomer‐based dosage form (Entex LA tablets); and to compare the in vitro dissolution of pseudoephedrine from a sustained‐release, hydroxypropylcellulose‐based dosage form (Entex PSE tablets) and four branded competitors with different sustained‐release matrixes.Design. Entex LA: In vitro testing by rotating bottle method and in vivo testing as double‐blind, randomized, crossover, 24‐hour study. Entex PSE and four competitors: in vitro testing by paddle method.Setting. A pharmaceut

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15

Samir, Gendy. "Audit of Pain Scores Post Nasal Surgeries." International Clinical and Medical Case Reports Journal 4, no. 5 (2025): 1–3. https://doi.org/10.5281/zenodo.15522977.

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A study was conducted to measure patients pain scores post nasal surgeries performed at both Emersons Green and Devizes Practice plus Hospital during the months of October and November 2024 Lignospan injection is commonly used in nasal surgeries as a local anaesthethic and decongestant prior to nasal surgical procedure. Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of nerve impulses, thereby effecting local anesthetic action. Each lignospan cartridge is a 2.2ml solution for injection that contains 44mg of lidocaine hydrochl

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16

Browne, Thom, Mark S. Gold, and David M. Martin. "The Rapidly Changing Composition of the Global Street Drug Supply and its Effects on High-risk Groups for COVID-19." Current Psychopharmacology 10, no. 2 (2021): 138–54. http://dx.doi.org/10.2174/2211556010666210125124645.

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Background: Globally, an alarming number of pharmaceutically active compounds are now routinely added to the street drugs of abuse, cocaine and heroin. In some cases, seventeen (17) or more potentially toxic compounds are found in a single street purchased bag or block of cocaine or heroin. Pharmacologically active compounds, impurities, or breakdown products from drug manufacturing and industrial chemicals (collectively referred to as toxic adulterants) are now found in street drugs. They include, but are not limited to: antipsychotics, antidepressants, anxiolytics, antihistamines, anthelmint

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17

Banu T.S, Vaseeha, Jaiswal Vikas Awdesh, and Mohammad Sameer Ansari. "Formulation and Evaluation of Transdermal Patches of Decongestant Drug." Research Journal of Pharmaceutical Dosage Forms and Technology, July 16, 2022, 195–98. http://dx.doi.org/10.52711/0975-4377.2022.00031.

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Pseudoephedrine HCl (PEH) is a sympathomimetic drug used as a nasal decongestant. In this study an attempt has been made to formulate transdermal films of PEH using HPMC and PVP as polymers, DMSO as plasticizer and DBP as permeation enhancer by solvent casting technique. The prepared films were evaluated for various physicochemical parameters viz., weight variation, drug content, surface pH, folding endurance, tensile strength WVTR and stability studies of optimized formulation. The in vitro drug release was determined by using modified Franz diffusion cell by using phosphate buffer (pH 7.4) a

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18

Bhargava, Samir, and Atul Sharma. "Contemporary Use Of Topical Decongestants: An Indian Perspective." International Journal Of Health & Medical Research 02, no. 08 (2023). http://dx.doi.org/10.58806/ijhmr.2023.v2i8n04.

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Background: Allergic rhinitis and sinusitis are commonly encountered in primary practice, and nasal congestion is a common symptom experienced by these patients. Thus, it is important to address nasal congestion when treating these conditions. Despite the availability of several treatment options, therapy is impacted by adverse effects and patient dissatisfaction. We conducted a survey to evaluate the prescribing practices of physicians treating allergic rhinitis and sinusitis, with a focus on the formulation of topical xylometazoline with moisturizers (hypromellose and sorbitol). Methods: We

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19

Hendeles, Leslie. "Selecting a Decongestant." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 13, no. 6P2 (1993). http://dx.doi.org/10.1002/j.1875-9114.1993.tb02781.x.

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Antihistamines and decongestants often are used interchangeably and in combination for a variety of upper respiratory illnesses ranging from allergic rhinitis to the common cold; yet, these two classes of drugs have distinct therapeutic actions. When administered alone, antihistamines are of no value in reducing nasal stuffiness. Therefore, many allergy products also contain decongestants. Conversely, cough‐cold remedies often contain antihistamines despite their lack of efficacy in these conditions. Nasal congestion, on the other hand, regardless of its cause, responds quite well to decongest

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20

Timothy, Chris Noel, J. S. Thaslima Nandhini, Sheeja S. Varghese, and S. Rajeshkumar. "Abies webbiana Ethanolic Extract Based Mouthwash and Its Antimicrobial and Cytotoxic Effect." Journal of Pharmaceutical Research International, December 29, 2021, 371–85. http://dx.doi.org/10.9734/jpri/2021/v33i62b35625.

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Aim: The aim of this study was to evaluate the antimicrobial and cytotoxic effect of Abies webbiana ethanolic extract based preparation of mouthwash and to compare these effects between different concentrations. Background: Abies webbiana leaves have been used in traditional siddha and ayurveda systems of medicine for common ailments such as cough, loss of appetite, indigestion, mental disorders, rheumatism, bronchitis, pulmonary infection, asthma, antiseptic and decongestant. Abies webbiana commonly known as talispatra belongs to family Pinaceae. The plant is distributed throughout Indi

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21

Trinh, Lily N., Diandra K. Smith, and Edward D. McCoul. "Redundancy of Pharmacologic Ingredients in Over‐the‐Counter Nasal Sprays." OTO Open 8, no. 4 (2024). http://dx.doi.org/10.1002/oto2.70022.

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AbstractObjectiveTo evaluate and determine the prevalence of ingredients in over‐the‐counter (OTC) nasal sprays.Study DesignCross‐sectional.SettingRetail pharmacies.MethodsAn inventory of brand‐name and generic OTC nasal sprays was recorded at five national pharmacy outlets in August 2023. Data regarding the active ingredients were collected on commercial websites, MedlinePlus and drugs.com, and frequency statistics were calculated.ResultsFive pharmacies were visited, at which 12 different brand names of nasal sprays were identified at multiple pharmacies. Nine brand names were associated with

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22

Warrier, Parvathy R., Rekhanath K C, and Balakrishnana VKV. "MANAGEMENT OF POOYALASA (ACUTE DACRYOCYSTITIS) - A CASE REPORT." Kerala Journal of Ayurveda 4, no. 1 (2025). https://doi.org/10.55718/kja.375.

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Dacryocystitis is an inflammatory condition of the lacrimal sac, often presenting with pain, swelling, and purulent discharge, primarily due to nasolacrimal duct obstruction. In Ayurveda, the condition is analogous to Pooyalasa, a chronic and recurrent pathology affecting the lacrimal apparatus. If untreated, it can lead to complications such as abscess formation, fistula, and systemic infections, emphasizing the need for timely and systematic management. This case report discusses a 48-year-old male presenting with a 3-month history of epiphora and purulent discharge from the right eye, progr

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23

Abdelfatah, Rehab M., and Maimana A. Magdy. "Green easily implemented spectrophotometric methods for concurrent determination of ephedrine hydrochloride and naphazoline nitrate in nasal preparations containing methylparaben." Journal of AOAC International, May 4, 2023. http://dx.doi.org/10.1093/jaoacint/qsad050.

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Abstract Background Spectrophotometric resolution of a mixture of several drugs is considered a cheaper, simpler and more versatile alternate compared to the costly chromatographic instruments. Objective The work aims to resolve the interfering spectra of ephedrine hydrochloride, naphazoline nitrate and methylparaben in nasal preparations using smart spectrophotometric methods. Methods In our work, derivative and dual wavelength methods were combined to eliminate this interference, under the name of derivative dual wavelength method. Other methods, namely successive derivative subtraction and

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24

Fu, Qiuxia, Yangjie Liu, Cao Peng, Tobias Achu Muluh, Umer Anayyat, and Liu Liang. "Recent Advancement in Inhaled Nano-drug Delivery for Pulmonary, Nasal, and Nose-to-brain Diseases." Current Drug Delivery 21 (January 24, 2024). http://dx.doi.org/10.2174/0115672018268047231207105652.

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Abstract: Pulmonary, nasal, and nose-to-brain diseases involve clinical approaches, such as bronchodilators, inhaled steroids, oxygen therapy, antibiotics, antihistamines, nasal steroids, decongestants, intranasal drug delivery, neurostimulation, and surgery to treat patients. However, systemic medicines have serious adverse effects, necessitating the development of inhaled formulations that allow precise drug delivery to the airways with minimum systemic drug exposure. Particle size, surface charge, biocompatibility, drug capacity, and mucoadhesive are unique chemical and physical features th

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25

Pandya, Mrugank, Bappaditya Chatterjee, and Srikar Ganti. "Self-emulsifying drug delivery system for oral anticancer therapy: constraints and recent development." Current Pharmaceutical Design 28 (June 6, 2022). http://dx.doi.org/10.2174/03666220606143443.

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Abstract: Oral anticancer therapy faces several drawbacks of low aqueous solubility, poor and irregular absorption from gastro-intestinal sites, high first-pass metabolism, food-influenced absorption, non-targeted delivery, severe systemic and local adverse effects, etc. Enhancement of oral bioavailability could reduce the drug load and associated adverse effects. Self-emulsifying drug delivery systems (SEDDS) can enhance in-vivo solubility and drug absorption from the gastrointestinal tract, bypass liver metabolism by lymphatic absorption and inhibit efflux transport. All these phenomena ulti

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