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Journal articles on the topic 'Decosan'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Orgel, Joseph P. R. O., Aya Eid, Olga Antipova, Jordi Bella, and John E. Scott. "Decorin Core Protein (Decoron) Shape Complements Collagen Fibril Surface Structure and Mediates Its Binding." PLoS ONE 4, no. 9 (2009): e7028. http://dx.doi.org/10.1371/journal.pone.0007028.

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Seymour, J. L., W. J. Henzel, B. Nevins, J. T. Stults, and R. A. Lazarus. "Decorsin. A potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor from the leech Macrobdella decora." Journal of Biological Chemistry 265, no. 17 (1990): 10143–47. http://dx.doi.org/10.1016/s0021-9258(19)38791-5.

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3

Kawaguchi, Takumi, Sachiyo Yoshio, Yuzuru Sakamoto, et al. "Impact of Decorin on the Physical Function and Prognosis of Patients with Hepatocellular Carcinoma." Journal of Clinical Medicine 9, no. 4 (2020): 936. http://dx.doi.org/10.3390/jcm9040936.

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The outcome of patients with hepatocellular carcinoma (HCC) is still poor. Decorin is a small leucine-rich proteoglycan, which exerts antiproliferative and antiangiogenic properties in vitro. We aimed to investigate the associations of decorin with physical function and prognosis in patients with HCC. We enrolled 65 patients with HCC treated with transcatheter arterial chemoembolization (median age, 75 years; female/male, 25/40). Serum decorin levels were measured using enzyme-linked immunosorbent assays; patients were classified into the High or Low decorin groups by median levels. Associatio

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Nemani, Neeharika, Loredana Santo, Homare Eda, et al. "Role Of Decorin In Multiple Myeloma (MM) Bone Marrow Microenvironment." Blood 122, no. 21 (2013): 1851. http://dx.doi.org/10.1182/blood.v122.21.1851.1851.

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Abstract Decorin is a small leucine rich proteoglycan found in the extracellular matrix of various connective tissues with potential effective tumor suppressor properties. Recently, it has been shown that decorin decreases in multiple myeloma (MM) patients compared to healthy volunteers, and also in patients with osteolytic bone lesions than non-osteolytic lesions. By using a cytokine array analysis we showed that decorin is down regulated in patients withdrawn from aminobisphosphanates for six months. These results led us to focus on decorin and its role in the bone marrow micro environment.

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Sofeu Feugaing, David Denis, Hans Kresse, Robert R. Greb, and Martin Götte. "A Novel 110-kDa Receptor Protein is Involved in Endocytic Uptake of Decorin by Human Skin Fibroblasts." Scientific World JOURNAL 6 (2006): 35–52. http://dx.doi.org/10.1100/tsw.2006.17.

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The small leucine-rich proteoglycan (SLRP) decorin is efficiently internalized by a variety of cultured cells. A 51-kDa protein has previously been described as a receptor mediating endocytosis of decorin and of the structurally related SLRP biglycan. Recent findings suggest that endocytosis of SLRPs may also be mediated by additional receptors. The class-A scavenger receptor, the endocytic mannose receptor, the epidermal growth factor receptor, and insulin-like growth factor-I receptor have emerged as candidates. We used a combined approach of immunoprecipitation and photoactivated cross-link

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6

Bahl, Neha, Glenn Stone, Mark McLean, Ken K. Y. Ho, and Vita Birzniece. "Decorin, a growth hormone-regulated protein in humans." European Journal of Endocrinology 178, no. 2 (2018): 145–52. http://dx.doi.org/10.1530/eje-17-0844.

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Context Growth hormone (GH) stimulates connective tissue and muscle growth, an effect that is potentiated by testosterone. Decorin, a myokine and a connective tissue protein, stimulates connective tissue accretion and muscle hypertrophy. Whether GH and testosterone regulate decorin in humans is not known. Objective To determine whether decorin is stimulated by GH and testosterone. Design Randomized, placebo-controlled, double-blind study. Participants and Intervention 96 recreationally trained athletes (63 men, 33 women) received 8 weeks of treatment followed by a 6-week washout period. Men re

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Goldoni, Silvia, Ashley Humphries, Alexander Nyström, et al. "Decorin is a novel antagonistic ligand of the Met receptor." Journal of Cell Biology 185, no. 4 (2009): 743–54. http://dx.doi.org/10.1083/jcb.200901129.

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Decorin, a member of the small leucine-rich proteoglycan gene family, impedes tumor cell growth by down-regulating the epidermal growth factor receptor. Decorin has a complex binding repertoire, thus, we predicted that decorin would modulate the bioactivity of other tyrosine kinase receptors. We discovered that decorin binds directly and with high affinity (Kd = ∼1.5 nM) to Met, the receptor for hepatocyte growth factor (HGF). Binding of decorin to Met is efficiently displaced by HGF and less efficiently by internalin B, a bacterial Met ligand. Interaction of decorin with Met induces transient

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Xaus, Jordi, Mònica Comalada, Marina Cardó, Annabel F. Valledor, and Antonio Celada. "Decorin inhibits macrophage colony-stimulating factor proliferation of macrophages and enhances cell survival through induction of p27Kip1 and p21Waf1." Blood 98, no. 7 (2001): 2124–33. http://dx.doi.org/10.1182/blood.v98.7.2124.

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Decorin is a small proteoglycan that is ubiquitous in the extracellular matrix of mammalian tissues. It has been extensively demonstrated that decorin inhibits tumor cell growth; however, no data have been reported on the effects of decorin in normal cells. Using nontransformed macrophages from bone marrow, results of this study showed that decorin inhibits macrophage colony-stimulating factor (M-CSF)–dependent proliferation by inducing blockage at the G1 phase of the cell cycle without affecting cell viability. In addition, decorin rescues macrophages from the induction of apoptosis after gro

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9

Wu, Wen Xuan, Qi Zhang, Nobuya Unno, Jan B. Derks, and Peter W. Nathanielsz. "Characterization of decorin mRNA in pregnant intrauterine tissues of the ewe and regulation by steroids." American Journal of Physiology-Cell Physiology 278, no. 1 (2000): C199—C206. http://dx.doi.org/10.1152/ajpcell.2000.278.1.c199.

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In this study, we characterized the changes in the extracellular matrix proteoglycan decorin in pregnant intrauterine tissues in late gestation and in association with labor and delivery in sheep. In addition, we examined the effects of estradiol and progesterone on regulation of decorin mRNA expression in myometrium from the nonpregnant ovariectomized sheep. Using suppression subtractive hybridization in combination with Northern blot analysis, we identified a significant increase in decorin mRNA in the pregnant sheep myometrium during labor. The abundance of decorin mRNA paralleled myometria

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10

Xie, Christopher, Dipon K. Mondal, Mikdat Ulas, Thomas Neill, and Renato V. Iozzo. "Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways." American Journal of Physiology-Cell Physiology 322, no. 3 (2022): C554—C566. http://dx.doi.org/10.1152/ajpcell.00016.2022.

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Decorin is a stromal-derived prototype member of the small leucine-rich proteoglycan gene family. In addition to its functions as a regulator of collagen fibrillogenesis and TGF-β activity soluble decorin acts as a pan-receptor tyrosine kinase (RTK) inhibitor. Decorin binds to various RTKs including EGFR HER2 HGFR/Met VEGFR2 TLR and IGFR. Although the molecular mechanism for the action of decorin on these receptors is not entirely elucidated overall decorin evokes transient activation of these receptors with suppression of downstream signaling cascades culminating in growth inhibition followed

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11

Mogyorosi, Andras, and Fuad N. Ziyadeh. "Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose." American Journal of Physiology-Renal Physiology 275, no. 5 (1998): F827—F832. http://dx.doi.org/10.1152/ajprenal.1998.275.5.f827.

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The core protein of the proteoglycan decorin binds and neutralizes transforming growth factor-β (TGF-β). Activation of TGF-β is crucial to tissue injury in diabetic nephropathy, but it is not currently known whether decorin plays a role in this disease. Mouse kidney cortex demonstrates more than a twofold increase in decorin mRNA after 1, 2, 3, and 6 wk of streptozotocin diabetes. Various mouse and rat renal cell types are studied in culture under normal or high-glucose conditions. Mouse glomerular mesangial and proximal tubular epithelial cells constitutively express decorin, and high glucose

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12

Neill, Thomas, Liliana Schaefer, and Renato V. Iozzo. "Decorin." American Journal of Pathology 181, no. 2 (2012): 380–87. http://dx.doi.org/10.1016/j.ajpath.2012.04.029.

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13

Guidetti, Gianni, Alessandra Bertoni, Manuela Viola, Enrica Tira, Cesare Balduini, and Mauro Torti. "The small proteoglycan decorin supports adhesion and activation of human platelets." Blood 100, no. 5 (2002): 1707–14. http://dx.doi.org/10.1182/blood.v100.5.1707.h81702001707_1707_1714.

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Decorin is a small leucine-rich proteoglycan able to interact with several molecules of the subendothelial matrix, such as collagen and fibronectin. In this work, we investigated the ability of purified decorin to support adhesion of human platelets. We found that gel-filtered platelets were actually able to interact with immobilized decorin. Platelet adhesion to decorin was time dependent, required the presence of Mg2+ ions, and was totally mediated by the protein core of the proteoglycan. Platelet stimulation with either adenosine diphosphate (ADP) or a thrombin receptor–activating peptide s

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Krumdieck, R., M. Höök, L. C. Rosenberg, and J. E. Volanakis. "The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex." Journal of Immunology 149, no. 11 (1992): 3695–701. http://dx.doi.org/10.4049/jimmunol.149.11.3695.

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Abstract Decorin, a small collagen-binding dermatan sulfate proteoglycan, is widely distributed as a component of extracellular matrices. Using a solid phase binding assay, we showed that decorin bound C1q at physiologic pH and ionic strength. The interaction did not require divalent cations and was time and temperature dependent reaching equilibrium in 4 h at 37 degrees C. Binding was specific and saturable with an apparent dissociation constant of 7.6 x 10(-9) M. Decorin was shown to bind pepsin-derived fragments containing the collagenous domain of C1q and collagenase-derived fragments cont

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BITTNER, Katharina, Claudia LISZIO, Petra BLUMBERG, Elke SCHÖNHERR, and Hans KRESSE. "Modulation of collagen gel contraction by decorin." Biochemical Journal 314, no. 1 (1996): 159–66. http://dx.doi.org/10.1042/bj3140159.

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The small dermatan sulphate protein decorin interacts via its core protein with fibrillar collagens, and its glycosaminoglycan chains were proposed to be capable of self-association. It was therefore of interest to study the role of decorin in the contraction of cell-populated collagen lattices. Stable transfection of dihydrofolate reductase-deficient CHO cells with decorin cDNA resulted in impaired collagen lattice contraction. Using normal human skin fibroblasts in serum-free cultures, inclusion of 0.3 μM decorin in the culture medium also led to a delayed collagen gel contraction. Protein-f

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Tjahjono, Nathaniel S., Divya Subramanian, Tarik Z. Shihabeddin та ін. "Effect of Decorin and Aligned Collagen Fibril Topography on TGF-β1 Activation of Corneal Keratocytes". Bioengineering 12, № 3 (2025): 259. https://doi.org/10.3390/bioengineering12030259.

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During corneal wound healing, transforming growth factor-beta 1 (TGF-β1) causes differentiation of quiescent keratocytes into myofibroblasts. Decorin has been investigated as a promising anti-fibrotic therapeutic for corneal healing due to its interaction with TGF-β1, collagen, and cell surface receptors. In this study, a novel microfluidic method for coating aligned collagen fibrils with decorin was developed to mimic the presence of decorin within the corneal stroma. Decorin was found to bind selectively to collagen and remained bound for at least five days. To investigate the effects of dec

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Schönherr, Elke, Cord Sunderkötter, Renato V. Iozzo, and Liliana Schaefer. "Decorin, a Novel Player in the Insulin-like Growth Factor System." Journal of Biological Chemistry 280, no. 16 (2005): 15767–72. http://dx.doi.org/10.1074/jbc.m500451200.

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Decorin is a multifunctional proteoglycan that is expressed by sprouting endothelial cells. Its expression supports capillary formation and cell survival. Previously, it was shown that some effects of decorin are mediated by protein kinase B and the cyclin-dependent kinase inhibitor, p21. However, the cell surface receptor responsible for these effects was unknown. We demonstrate that decorin binds to the insulin-like growth factor-I (IGF-I) receptor on endothelial cells with an affinity in the nanomolar range (KD= 18 nm), which is comparable with IGF-I (KD= 1.2 nm). Furthermore, decorin can b

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Reszegi, Andrea, Zsolt Horváth, Katalin Karászi, et al. "The Protective Role of Decorin in Hepatic Metastasis of Colorectal Carcinoma." Biomolecules 10, no. 8 (2020): 1199. http://dx.doi.org/10.3390/biom10081199.

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Decorin, the prototype member of the small leucine-rich proteoglycan gene family of extracellular matrix (ECM) proteins, acts as a powerful tumor suppressor by inducing the p21Waf1/Cip1 cyclin-dependent kinase inhibitor, as well as through its ability to directly bind and block the action of several tyrosine kinase receptors. Our previous studies suggested that the lack of decorin promotes hepatic carcinogenesis in mice. Based on this, we set out to investigate whether excess decorin may protect against the liver metastases of colon carcinoma. We also analyzed the effect of decorin in tissue m

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Coppel Areizaga, Rosario. "Relieves que decoran los pedestales de las esculturas de la Reina Cristina de Suecia." Archivo Español de Arte 70, no. 279 (1997): 310–15. http://dx.doi.org/10.3989/aearte.1997.v70.i279.652.

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Li, X., T. Nakano, H. S. Chae, H. Sunwoo, and J. S. Sim. "Production of chicken egg yolk antibody (IgY) against bovine proteoglycan." Canadian Journal of Animal Science 78, no. 3 (1998): 287–91. http://dx.doi.org/10.4141/a97-123.

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This study was undertaken to examine the immune response of chickens to bovine decorin, which is a proteoglycan bearing a single chain of dermatan sulphate. Three 35-wk-old Single Comb White Leghorn hens were immunized with decorin by intramuscular injection, and eggs produced by each bird were examined by ELISA for anti-decorin antibody activity in the yolk. The antibody activity started to increase 7 d after immunization, rapidly increased and remained relatively constant after 35 d. The polyclonal antibody obtained was then examined by ELISA inhibition assay with samples of bovine decorin t

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Vial, Cecilia, Jaime Gutiérrez, Cristian Santander, Daniel Cabrera, and Enrique Brandan. "Decorin Interacts with Connective Tissue Growth Factor (CTGF)/CCN2 by LRR12 Inhibiting Its Biological Activity." Journal of Biological Chemistry 286, no. 27 (2011): 24242–52. http://dx.doi.org/10.1074/jbc.m110.189365.

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Fibrotic disorders are the end point of many chronic diseases in different tissues, where an accumulation of the extracellular matrix occurs, mainly because of the action of the connective tissue growth factor (CTGF/CCN2). Little is known about how this growth factor activity is regulated. We found that decorin null myoblasts are more sensitive to CTGF than wild type myoblasts, as evaluated by the accumulation of fibronectin or collagen III. Decorin added exogenously negatively regulated CTGF pro-fibrotic activity and the induction of actin stress fibers. Using co-immunoprecipitation and in vi

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Biaoxue, Rong, Cai Xiguang, Liu Hua, et al. "Decreased Expression of Decorin and p57(KIP2) Correlates with Poor Survival and Lymphatic Metastasis in Lung Cancer Patients." International Journal of Biological Markers 26, no. 1 (2011): 9–21. http://dx.doi.org/10.5301/jbm.2011.6372.

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Purpose Decorin, p57(KIP2), and TGF-beta 1 have been investigated as prognostic factors because they appear to be associated with tumorigenesis; however, the effect of decorin and p57(KIP2) in lung cancer remains poorly understood. The purpose of this study was to examine the expression of decorin, p57(KIP2), and TGF-beta 1 in 64 lung cancer specimens and 36 normal lung specimens, and to analyze the relationships with respect to clinicopathological features and patient survival in lung cancer. Methods The expression levels of decorin, p57(KIP2), and TGF-beta 1 were examined by in situ hybridiz

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Zhao, Jingsong, Patricia J. Sime, Pablo Bringas, Jack Gauldie та David Warburton. "Adenovirus-mediated decorin gene transfer prevents TGF-β-induced inhibition of lung morphogenesis". American Journal of Physiology-Lung Cellular and Molecular Physiology 277, № 2 (1999): L412—L422. http://dx.doi.org/10.1152/ajplung.1999.277.2.l412.

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Excessive transforming growth factor (TGF)-β signaling has been implicated in pulmonary hypoplasia associated with bronchopulmonary dysplasia, a chronic lung disease of human prematurity featuring pulmonary fibrosis. This implies that inhibitors of TGF-β could be useful therapeutic agents. Because exogenous TGF-β ligands are known to inhibit lung branching morphogenesis and cytodifferentiation in mouse embryonic lungs in ex vivo culture, we examined the capacity of a naturally occurring inhibitor of TGF-β activity, the proteoglycan decorin, to overcome the inhibitory effects of exogenous TGF-β

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OKAMOTO, Osamu, Sakuhei FUJIWARA, Mayumi ABE та Yasufumi SATO. "Dermatopontin interacts with transforming growth factor β and enhances its biological activity". Biochemical Journal 337, № 3 (1999): 537–41. http://dx.doi.org/10.1042/bj3370537.

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Dermatopontin, a recently found low-molecular-mass component of the extracellular matrix, was studied for its interaction with decorin and transforming growth factor β (TGF-β) and its influence on TGF-β bioactivity. Dermatopontin reacted with decorin with an apparent Kd of 100 nM in a solid-phase assay. Dermatopontin inhibited the formation of the decorin–TGF-β1 complex. Decorin also competed with dermatopontin for the binding of this cytokine. The dermatopontin–decorin complex bound 3-fold more TGF-β1 than did each component individually, and binding was inhibited more strongly by decorin pre

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LAINE, Pauliina, Niina REUNANEN, Laura RAVANTI, et al. "Activation of extracellular signal-regulated protein kinase1,2 results in down-regulation of decorin expression in fibroblasts." Biochemical Journal 349, no. 1 (2000): 19–25. http://dx.doi.org/10.1042/bj3490019.

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Decorin is a small leucine-rich extracellular matrix proteoglycan, the expression of which is down-regulated in proliferating and malignantly transformed cells. In the present study we show that the expression of decorin in fibroblasts is suppressed by epidermal growth factor (EGF) and PMA, and that the effect of both is potently inhibited by blocking the extracellular signal-regulated protein kinase (ERK)1,2 signalling pathway (Raf/MEK1,2/ERK1,2) with the specific MAPK/ERK kinase (MEK)1,2 inhibitor, PD98059. In addition, specific activation of ERK1,2 by adenovirus-mediated expression of const

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Li, Xin, Angela Pennisi, and Shmuel Yaccoby. "Role of decorin in the antimyeloma effects of osteoblasts." Blood 112, no. 1 (2008): 159–68. http://dx.doi.org/10.1182/blood-2007-11-124164.

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Abstract Building on our previous report that osteoblasts and increased bone formation have a negative impact on myeloma cell growth in a subset of patients, we investigated the role of decorin, the main small leucine-rich proteoglycan (SLRP) expressed and produced by osteoblasts, in the antimyeloma effects of osteoblasts. In coculture experiments with osteoblasts, primary myeloma cell survival was significantly higher when decorin expression in osteoblasts was knocked down by short-hairpin RNA. Coculture experiments of myeloma cells and supporting osteoclasts in the presence of osteoblast-con

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Swan, B. C., P. Murthi, G. Rajaraman, et al. "Decorin expression is decreased in human idiopathic fetal growth restriction." Reproduction, Fertility and Development 22, no. 6 (2010): 949. http://dx.doi.org/10.1071/rd09240.

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Fetal growth restriction (FGR) is a clinically significant pregnancy disorder in which the fetus fails to achieve its full growth potential in utero. Most cases of FGR are idiopathic and are associated with placental thrombosis. Previous studies suggest that proteoglycans, such as decorin, that contain the glycosaminoglycan dermatan sulfate are the principal anticoagulants in the normal placenta. The present study investigated decorin expression in placentas from pregnancies complicated by idiopathic FGR (n = 26) and gestation-matched controls (n = 27). Real-time polymerase chain reaction demo

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LIANG, Shuo, Jin-fu XU, Wei-jun CAO, Hui-ping LI, and Cheng-ping HU. "Human decorin regulates proliferation and migration of human lung cancer A549 cells." Chinese Medical Journal 126, no. 24 (2013): 4736–41. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20130207.

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Background Decorin is a small leucine-rich proteoglycan and it plays an important role in regulation of cell growth and migration in various tumor cell lines. Decorin was found down-regulated in non-small cell lung cancer tissue and may be involved in regulation of lung cancer development. Methods In this study, lentivirus-mediated RNA interference and over expression were employed to change the expression levels of decorin in lung cancer A549 cells. We tested the cell cycle of A549 cells and the expression of transforming growth factor (TGF)-β1, cyclin D1, epidermal growth factor receptor (EG

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Johnstone, B., M. Markopoulos, P. Neame, and B. Caterson. "Identification and characterization of glycanated and non-glycanated forms of biglycan and decorin in the human intervertebral disc." Biochemical Journal 292, no. 3 (1993): 661–66. http://dx.doi.org/10.1042/bj2920661.

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Immunological studies revealed the presence of several different forms of biglycan and decorin in human intervertebral-disc tissues (annulus fibrosus, nucleus pulposus and cartilage end-plate). In the young intervertebral disc, glycosaminoglycan-containing (glycanated) forms of both biglycan and decorin represented a greater proportion of the total proteoglycan population present in extracts of annulus fibrosus and cartilage end-plate compared with extracts of nucleus pulposus, in which they were barely detectable. In older discs the glycanated forms of biglycan and decorin represented only a

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Schönherr, E., L. A. Beavan, H. Hausser, H. Kresse, and L. A. Culp. "Differences in decorin expression by papillary and reticular fibroblasts in vivo and in vitro." Biochemical Journal 290, no. 3 (1993): 893–99. http://dx.doi.org/10.1042/bj2900893.

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Immunostaining of adult human skin shows that the small dermatan sulphate proteoglycan decorin is abundant in the whole dermal layer but absent from the epidermis. In the papillary layer adjacent to the dermal-epidermal border, more decorin was detected than in the reticular layer of the dermis. Expression of decorin mRNA by cells in the papillary dermis could also be shown by in situ hybridization. In contrast, biglycan, another small chondroitin sulphate/dermatan sulphate proteoglycan, is found only at the dermal-epidermal border. Therefore the biosynthesis of these two proteoglycans by papi

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Shimizukawa, Minoru, Masahito Ebina, Ko Narumi, Toshiaki Kikuchi, Hiroshi Munakata, and Toshihiro Nukiwa. "Intratracheal gene transfer of decorin reduces subpleural fibroproliferation induced by bleomycin." American Journal of Physiology-Lung Cellular and Molecular Physiology 284, no. 3 (2003): L526—L532. http://dx.doi.org/10.1152/ajplung.00131.2002.

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Decorin, a small leucin-rich proteoglycan, is a negative regulator of transforming growth factor-β, but the antifibrotic effect of decorin gene transfer has not been examined in a mouse model of usual interstitial pneumonia (UIP). We constructed a replication-defective recombinant adenovirus harboring human decorin gene (AdCMV.DC) and administered 1 × l09plaque-forming units of AdCMV.DC intratracheally or intravenously to C57BL/6 mice with intraperitoneal injection of bleomycin, which induces a subpleural fibroproliferation, mimicking UIP, by day 28. Only intratracheal administration of AdCMV.

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Calmus, Megan L., Elyse E. Macksoud, Richard Tucker, Renato V. Iozzo, and Beatrice E. Lechner. "A mouse model of spontaneous preterm birth based on the genetic ablation of biglycan and decorin." REPRODUCTION 142, no. 1 (2011): 183–94. http://dx.doi.org/10.1530/rep-10-0387.

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Preterm premature rupture of membranes is responsible for one-third of preterm births. Ehlers–Danlos syndrome (EDS) is associated with preterm premature rupture of membranes in humans. In particular, an EDS variant is caused by a genetic mutation resulting in abnormal secretion of biglycan and decorin, two small leucine-rich proteoglycans highly expressed in reproductive tissues. Because biglycan/decorin null mutant (Bgn−/−Dcn−/−) mice demonstrate phenotypic changes similar to EDS, we used this model to test whether either biglycan or decorin or both play a role in the attainment of successful

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Li, Longhu, Hideshi Okada, Genzou Takemura, et al. "Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction." American Journal of Physiology-Heart and Circulatory Physiology 297, no. 4 (2009): H1504—H1513. http://dx.doi.org/10.1152/ajpheart.00194.2009.

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The small leucine-rich proteoglycan decorin is a natural inhibitor of transforming growth factor-β (TGF-β) and exerts antifibrotic effects in heart and to stimulate skeletal muscle regeneration. We investigated decorin's chronic effects on postinfarction cardiac remodeling and dysfunction. Myocardial infarction (MI) was induced in mice by left coronary artery ligation. An adenoviral vector encoding human decorin (Ad. CAG-decorin) was then injected into the hindlimbs on day 3 post-MI (control, Ad.CAG-LacZ). Four weeks post-MI, the decorin-treated mice showed significant mitigation of the left v

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Bray, Jonathan P., Matthew R. Perrott, and John S. Munday. "Immunostaining for VEGF and Decorin Predicts Poor Survival and Recurrence in Canine Soft Tissue Sarcoma." Veterinary Sciences 10, no. 4 (2023): 256. http://dx.doi.org/10.3390/vetsci10040256.

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The aim of this study was to investigate whether using immunohistochemistry to detect the angiogenic proteins vascular endothelial growth factor (VEGF) and decorin can help predict the risk of local recurrence of, or death from, canine soft tissue sarcoma (STS). VEGF and decorin were detected using validated immunohistochemical methods on 100 formalin-fixed paraffin-embedded samples of canine STS. The tumours had been resected previously, with clinical outcome determined by questionnaire. Each slide was assessed by light microscopy and the pattern of immunostaining with VEGF and decorin determ

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Chern, Yahn-Bor, Po-Yu Huang, Yu-Li Lin, Chih-Hsien Wang, Jen-Pi Tsai, and Bang-Gee Hsu. "Decreased Serum Decorin Levels Are Correlated with Aortic Stiffness as Assessed Using Carotid–Femoral Pulse Wave Velocity in Patients with Peritoneal Dialysis." Life 15, no. 4 (2025): 541. https://doi.org/10.3390/life15040541.

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In patients on chronic peritoneal dialysis (PD), aortic stiffness (AS) is a common cardiovascular condition that can predict cardiovascular events and mortality. Decorin is a small leucine-rich proteoglycan that plays a vital role in extracellular matrix organization and vascular remodeling. The relationship between decorin and AS in patients with PD remains unclear. We enrolled 140 patients on PD and collected their demographic, anthropometric, and biochemical data. Serum decorin levels were measured using enzyme-linked immunosorbent assay. Based on carotid–femoral pulse wave velocity (cfPWV)

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Dong, Yuanji, Jixin Zhong, and Lingli Dong. "The Role of Decorin in Autoimmune and Inflammatory Diseases." Journal of Immunology Research 2022 (August 17, 2022): 1–11. http://dx.doi.org/10.1155/2022/1283383.

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Decorin is an extracellular matrix protein that belongs to the family of small leucine-rich proteoglycans. As a matrix protein, the first discovered role of decorin is participating in collagen fibril formation. Many other functions of decorin in various biological processes have been subsequently identified. Decorin is involved in an extensive signaling network and can interact with other extracellular matrix components, growth factors, receptor tyrosine kinases, and various proteases. Decorin has been shown to be involved in wound repair, cell cycle, angiogenesis, tumor metastasis, and autop

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Anwar, Rizwan, Bilal Habib, Yasir Mustafa, Asma Kazi, Omer Farooq, and Mufassar Nishat. "Validation of Levels of Decorin as A Reliable Biomarker of Osteoarthritis: Comparison of Serum and Synovial Fluid Levels." Pakistan Journal of Medical and Health Sciences 16, no. 11 (2022): 324–27. http://dx.doi.org/10.53350/pjmhs20221611324.

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Objective: The proteoglycan decorin, which plays an important part in the aetiology of osteoarthritis as well as a role in the binding of collagen, was the focus of this study's background information and objectives (OA). This investigation was carried out with the objectives of determining the levels of decorin in the blood and synovial fluid of patients who suffered from knee OA and determining whether or not these levels had a correlation with OA and the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) score. Place of Study: Islam medical college Sialkot Duration: December 2

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Ferdous, Zannatul, Victoria Mariko Wei, Renato Iozzo, Magnus Höök та Kathryn Jane Grande-Allen. "Decorin-transforming Growth Factor-β Interaction Regulates Matrix Organization and Mechanical Characteristics of Three-dimensional Collagen Matrices". Journal of Biological Chemistry 282, № 49 (2007): 35887–98. http://dx.doi.org/10.1074/jbc.m705180200.

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The small leucine-rich proteoglycan decorin has been demonstrated to be a key regulator of collagen fibrillogenesis; decorin deficiencies lead to irregularly shaped collagen fibrils and weakened material behavior in postnatal murine connective tissues. In an in vitro investigation of the contributions of decorin to tissue organization and material behavior, model tissues were engineered by seeding embryonic fibroblasts, harvested from 12.5–13.5 days gestational aged decorin null (Dcn-/-) or wild-type mice, within type I collagen gels. The resulting three-dimensional collagen matrices were cult

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Scott, P. G., C. M. Dodd, A. Ghahary, Y. J. Shen, and E. E. Tredget. "Fibroblasts from Post-Burn Hypertrophic Scar Tissue Synthesize Less Decorin than Normal Dermal Fibroblasts." Clinical Science 94, no. 5 (1998): 541–47. http://dx.doi.org/10.1042/cs0940541.

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1. Fibroblast cultures were established from biopsies of hypertrophic scar and normal dermis taken from nine patients recovering from second- and third-degree burns. The capacity of these fibroblasts to synthesize the small proteoglycan decorin was assessed by quantitative Western blot analysis of conditioned medium collected from confluent cultures. Levels of mRNA for decorin were assessed by quantitative Northern analysis. Since transforming growth factor-β1 is implicated in various fibrotic conditions, including post-burn hypertrophic scar, its effect on decorin synthesis by these paired fi

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Mavrogonatou, Eleni, Adamantia Papadopoulou, Asimina Fotopoulou, et al. "Down-Regulation of the Proteoglycan Decorin Fills in the Tumor-Promoting Phenotype of Ionizing Radiation-Induced Senescent Human Breast Stromal Fibroblasts." Cancers 13, no. 8 (2021): 1987. http://dx.doi.org/10.3390/cancers13081987.

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Down-regulation of the small leucine-rich proteoglycan decorin in the stroma is considered a poor prognostic factor for breast cancer progression. Ionizing radiation, an established treatment for breast cancer, provokes the premature senescence of the adjacent to the tumor stromal fibroblasts. Here, we showed that senescent human breast stromal fibroblasts are characterized by the down-regulation of decorin at the mRNA and protein level, as well as by its decreased deposition in the pericellular extracellular matrix in vitro. Senescence-associated decorin down-regulation is a long-lasting proc

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Nyman, Marie C., Anne B. Jokilammi, Pia C. Boström, et al. "Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells." Journal of Histochemistry & Cytochemistry 67, no. 7 (2019): 511–22. http://dx.doi.org/10.1369/0022155419845373.

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The extracellular matrix proteoglycan decorin is well-known for its oncosuppressive activity. Here, decorin expression was examined in human vulva carcinoma tissue samples and in primary and commercial cell lines representing this malignant disease. Furthermore, the effect of adenovirus-mediated decorin cDNA (Ad-DCN) transduction on the viability, proliferation, and the expression and activity of the epidermal growth factor receptor (ErbB/HER) family members of the cell lines were investigated. Using in situ hybridization and immunohistochemistry for decorin, it was demonstrated that malignant

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Kubo, Eri, Shinsuke Shibata, Teppei Shibata, Hiroshi Sasaki, and Dhirendra P. Singh. "Role of Decorin in the Lens and Ocular Diseases." Cells 12, no. 1 (2022): 74. http://dx.doi.org/10.3390/cells12010074.

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Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyrosine kinases. Decorin also modulates the growth factors, cell proliferation, migration, and angiogenesis. It has been reported to be involved in many ischemic and fibrotic eye diseases, such as congenital stromal dystrophy of the cornea, anterior subcapsular fibrosis of the lens, proliferative vitreoretinopathy, et al. Furthermore, recent evidence

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SÄÄMÄNEN, Anna-Marja K., Heli J. SALMINEN, A. Juho RANTAKOKKO, Dick HEINEGÅRD, and Eero I. VUORIO. "Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint." Biochemical Journal 355, no. 3 (2001): 577–85. http://dx.doi.org/10.1042/bj3550577.

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The genomic structure of murine fibromodulin was determined, and its age-related expression and distribution were characterized in knee epiphyses, with decorin studied for reference. Fibromodulin, as well as decorin, have roles in collagen fibrillogenesis both in vitro and in vivo. The murine fibromodulin gene, Fmod, was similar with that in other species, with three exons and 86% of the translated sequence in exon 2. The 2.7kb long cDNA contains an open reading frame of 1131nt. Fibromodulin mRNA levels were highest in tissues rich in fibrillar collagens type I or type II. During growth, the d

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Chaudhary, Kunal, Harold Moore, Ashish Tandon, Suneel Gupta, Ramesh Khanna, and Rajiv R. Mohan. "Nanotechnology and adeno-associated virus-based decorin gene therapy ameliorates peritoneal fibrosis." American Journal of Physiology-Renal Physiology 307, no. 7 (2014): F777—F782. http://dx.doi.org/10.1152/ajprenal.00653.2013.

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Peritoneal dialysis (PD) is a life-sustaining therapy for end-stage renal disease (ESRD), used by 10–15% of the dialysis population worldwide. Peritoneal fibrosis (PF) is a known complication of long-term PD and frequently follows episodes of peritonitis, rendering the peritoneal membrane inadequate for dialysis. Transforming growth factor (TGF)-β is an inducer of fibrosis in several tissues and organs, and its overexpression has been correlated with PF. Animal models of peritonitis have shown an increase in expression of TGF-β in the peritoneal tissue. Decorin, a proteoglycan and component of

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Adany, R., and R. V. Iozzo. "Hypomethylation of the decorin proteoglycan gene in human colon cancer." Biochemical Journal 276, no. 2 (1991): 301–6. http://dx.doi.org/10.1042/bj2760301.

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We have previously reported that the connective tissue stroma of human colon carcinoma contains elevated amounts of decorin, a small proteoglycan involved in the regulation of matrix formation and cell proliferation. These biochemical changes were correlated with increased mRNA levels and general hypomethylation of the decorin gene in human colon cancer DNA. In this report we use a quantitative polymerase chain reaction method coupled with digestion of the DNA template by methylation-sensitive restriction endonucleases to investigate in detail the location of hypomethylated sites in decorin ge

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Svensson, Maja, Johan Ohlsson, Sofie Olsson Hau, Alexandra Petersson, and Karin Jirström. "Abstract C030: Serum levels and tumor tissue organization of decorin in pancreatic cancer: Links to chemoresistance and disease aggressiveness." Cancer Research 84, no. 2_Supplement (2024): C030. http://dx.doi.org/10.1158/1538-7445.panca2023-c030.

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Abstract Pancreatic cancer has nearly paralleling incidence and mortality rates. Only 15-20% of the tumors are resectable at presentation, and for the majority of patients the situation is palliative. Treatment options are limited to standard chemotherapy, and tumor response is often transient. The longitudinal observational clinical study Chemotherapy, Host response And Molecular dynamics in Periampullary cancer (CHAMP) aims to contribute with new insights on this devastating disease through longitudinal blood sampling during adjuvant and palliative chemotherapy and comprehensive analysis of

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Kunicki, Thomas J., Daniel Diaz, Shirley A. Williams, Richard W. Farndale та Diane J. Nugent. "The Integrin α2 Dimorphism E534K Modulates Platelet Binding to Decorin but Not Collagen I",. Blood 118, № 21 (2011): 3256. http://dx.doi.org/10.1182/blood.v118.21.3256.3256.

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Abstract Abstract 3256 Background. Integrin a2b1-mediated adhesion to collagens supports cellular attachment, while decorin binding by a2b1 often attenuates adhesion. Collagen I binds to the a2 I-domain via the triple-helical sequence GFOGER, but the decorin binding site is not within the a2 I-domain and has not yet been identified. A single nucleotide polymorphism in the a2 gene ITGA2 (rs1801106) (G1600A) resulting in the amino acid substitution glutamate-534 to lysine-534 (E534K) is the basis for one of the most important human platelet alloantigen (HPA) systems, HPA-5, yet HPA-5 alleles do

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Low, Shermaine W. Y., Tanuja Vaidya, Santosh G. K. Gadde, et al. "Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy." Life 11, no. 12 (2021): 1421. http://dx.doi.org/10.3390/life11121421.

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Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization. Current treatment strategies include intravitreal anti-vascular endothelial growth factor (VEGF) or steroidal injections, laser photocoagulation, or vitrectomy in severe cases. However, treatment may require multiple modalities or repeat treatments due to variable response. Though DR management has achieved great success, improved, long-lasting, and

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Ono, Yoshihiro Joshua, Yoshito Terai, Akiko Tanabe, et al. "Decorin induced by progesterone plays a crucial role in suppressing endometriosis." Journal of Endocrinology 223, no. 2 (2014): 203–16. http://dx.doi.org/10.1530/joe-14-0393.

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Dienogest, a synthetic progestin, has been shown to be effective against endometriosis, although it is still unclear as to how it affects the ectopic endometrial cells. Decorin has been shown to be a powerful endogenous tumor repressor acting in a paracrine fashion to limit tumor growth. Our objectives were to examine the direct effects of progesterone and dienogest on the in vitro proliferation of the human ectopic endometrial epithelial and stromal cell lines, and evaluate as to how decorin contributes to this effect. We also examined DCN mRNA expression in 50 endometriosis patients. The gro

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Hausser, H., and H. Kresse. "Binding of heparin and of the small proteoglycan decorin to the same endocytosis receptor proteins leads to different metabolic consequences." Journal of Cell Biology 114, no. 1 (1991): 45–52. http://dx.doi.org/10.1083/jcb.114.1.45.

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Decorin, a small interstitial dermatan sulfate proteoglycan, is turned over in cultured cells of mesenchymal origin by receptor-mediated endocytosis followed by intralysosomal degradation. Two endosomal proteins of 51 and 26 kD have been implicated in the endocytotic process because of their interaction with decorin core protein. However, heparin and protein-free dermatan sulfate were able to inhibit endocytosis of decorin in a concentration-dependent manner. After Western blotting of endosomal proteins, there was competition for binding to the 51- and 26-kD proteins between heparin and decori

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