Academic literature on the topic 'Decoy liposomes'

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Journal articles on the topic "Decoy liposomes"

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Ayllon, Marcelo, Gamid Abatchev, Andrew Bogard, Rosey Whiting, Sarah E. Hobdey, and Daniel Fologea. "Liposomes Prevent In Vitro Hemolysis Induced by Streptolysin O and Lysenin." Membranes 11, no. 5 (2021): 364. http://dx.doi.org/10.3390/membranes11050364.

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The need for alternatives to antibiotics in the fight against infectious diseases has inspired scientists to focus on antivirulence factors instead of the microorganisms themselves. In this respect, prior work indicates that tiny, enclosed bilayer lipid membranes (liposomes) have the potential to compete with cellular targets for toxin binding, hence preventing their biological attack and aiding with their clearance. The effectiveness of liposomes as decoy targets depends on their availability in the host and how rapidly they are cleared from the circulation. Although liposome PEGylation may i
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Hendricks, Gabriel L., Lourdes Velazquez, Serena Pham, et al. "Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses." Antiviral Research 116 (April 2015): 34–44. http://dx.doi.org/10.1016/j.antiviral.2015.01.008.

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Buchanan, Kyle D., Shao-Ling Huang, Hyunggun Kim, David D. McPherson та Robert C. MacDonald. "Encapsulation of NF-κB decoy oligonucleotides within echogenic liposomes and ultrasound-triggered release". Journal of Controlled Release 141, № 2 (2010): 193–98. http://dx.doi.org/10.1016/j.jconrel.2009.09.017.

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Tomita, Naruya, Masatsugu Horiuchi, Sawako Tomita, et al. "An oligonucleotide decoy for transcription factor E2F inhibits mesangial cell proliferation in vitro." American Journal of Physiology-Renal Physiology 275, no. 2 (1998): F278—F284. http://dx.doi.org/10.1152/ajprenal.1998.275.2.f278.

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The transcription factor E2F controls expression of several genes involved in cell proliferation including c- myc, c- myb, proliferating cell nuclear antigen (PCNA), and cdk2 kinase. Having established that both PCNA and cdk2 kinase are induced in rat mesangial cells (MC) by serum stimulation, we attempted to inhibit MC proliferation in vitro by transfecting these cells with cationic liposomes containing a synthetic double-stranded oligodeoxynucleotide (ODN) with high affinity for E2F. Using a gel mobility shift assay, we detected increased specific binding of E2F in MC following serum stimula
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Buchanan, Kyle D., ShaoLing Huang, Susan D. Tiukinhoy-Laing, David D. McPherson, and Robert C. MacDonald. "1024. Encapsulation of the NF-kB Decoy Oligonucleotide in Echogenic Liposomes and Its Ultrasound-Triggered Release." Molecular Therapy 13 (2006): S394. http://dx.doi.org/10.1016/j.ymthe.2006.08.1119.

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Borgatti, Monica, Laura Breda, Rita Cortesi та ін. "Cationic liposomes as delivery systems for double-stranded PNA–DNA chimeras exhibiting decoy activity against NF-κB transcription factors". Biochemical Pharmacology 64, № 4 (2002): 609–16. http://dx.doi.org/10.1016/s0006-2952(02)01188-7.

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Kraus, Damian, M. Edward Medof, and Carolyn Mold. "Complementary Recognition of Alternative Pathway Activators by Decay-Accelerating Factor and Factor H." Infection and Immunity 66, no. 2 (1998): 399–405. http://dx.doi.org/10.1128/iai.66.2.399-405.1998.

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ABSTRACT The alternative complement pathway (ACP) functions as a surveillance mechanism by which microorganisms are opsonized with C3b in the absence of specific antibodies. The effectiveness of the ACP relies on its ability to distinguish self from non-self. This recognition function is mediated by C3 regulatory proteins including serum factor H, membrane cofactor protein (MCP), and membrane decay-accelerating factor (DAF). H activity against bound C3b can be increased by host components such as sialic acid and decreased by microbial polysaccharides. DAF and MCP may also recognize cell surfac
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Pilch, Ewa, and Witold Musiał. "Selected Physicochemical Properties of Lyophilized Hydrogel with Liposomal Fraction of Calcium Dobesilate." Materials 11, no. 11 (2018): 2143. http://dx.doi.org/10.3390/ma11112143.

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Lyophilization is the process of drying and improving the stability of various pharmaceutical preparations. In this work we evaluated the properties of 11 hydrophilic gels calcium dobesilate with liposomes based on soybean lecithin, subjected to the freeze-drying procedure. Liposomes were produced by using method thin lipid film. Lyophilization was carried out under conditions of temperature equal (−30 °C) and pressure 0.37 mbar. We evaluated the preparations with dynamic light scattering (DLS) method, optical microscopy and Fourier-transform infrared spectroscopy (FTIR). In this work we prese
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Gabrielska, Janina, and Jan Oszmiański. "Antioxidant Activity of Anthocyanin Glycoside Derivatives Evaluated by the Inhibition of Liposome Oxidation." Zeitschrift für Naturforschung C 60, no. 5-6 (2005): 399–407. http://dx.doi.org/10.1515/znc-2005-5-606.

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Cyanidin-3-glycosides (arabinoside, rutinoside, galactoside and glucoside) and delphinidin- 3-rutinoside were examined for their ability to inhibit lipid peroxidation induced either by Fe(II) ions, UV irradiation or 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) peroxyl radicals in a liposomal membrane system. The antioxidant abilities of anthocyanins were compared with a water-soluble tocopherol derivative, trolox. The antioxidant efficacies of these compounds were evaluated by their ability to inhibit the fluorescence intensity decay of the extrinsic probe 3-[p-(6-phenyl)-1,3,5,-hexatr
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Ramasamy, Thiruganesh, Xucai Chen, Bin Qin, Daniel E. Johnson, Jennifer R. Grandis, and Flordeliza S. Villanueva. "STAT3 decoy oligonucleotide-carrying microbubbles with pulsed ultrasound for enhanced therapeutic effect in head and neck tumors." PLOS ONE 15, no. 11 (2020): e0242264. http://dx.doi.org/10.1371/journal.pone.0242264.

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Signal transducer and activator of transcription-3 (STAT3) is an oncogenic transcription factor implicated in carcinogenesis, tumor progression, and drug resistance in head and neck squamous cell carcinoma (HNSCC). A decoy oligonucleotide targeting STAT3 offers a promising anti-tumor strategy, but achieving targeted tumor delivery of the decoy with systemic administration poses a significant challenge. We previously showed the potential for STAT3 decoy-loaded microbubbles, in conjunction with ultrasound targeted microbubble cavitation (UTMC), to decrease tumor growth in murine squamous cell ca
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Dissertations / Theses on the topic "Decoy liposomes"

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Hendricks, Gabriel L. "Modulating Influenza and Heparin Binding Viruses’ Pathogenesis with Extrinsic Receptor Decoy Liposomes: A Dissertation." eScholarship@UMMS, 2013. http://escholarship.umassmed.edu/gsbs_diss/674.

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Influenza is a severe disease in humans and animals, causing upwards of 40,000 deaths every year in America alone. Influenza A virus (IAV) also causes periodic pandemics every 10 to 50 years, killing millions of people. Despite this, very few effective therapies are available. All strains of IAV are prone to developing resistance to antibodies due to the high mutation rate in the viral genome. Because of this mutation rate, a yearly vaccine must be generated before every flu season, and efficacy varies year to year. IAV has also mutated to escape several of the clinically-approved small molecu
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