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Journal articles on the topic 'DED Associates Ltd'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Gajanan, Sormare Suraj Nirwan Deep Selokar Vrushabh Hete Nishanth Awandekar Milind Umekar. "A Comprehensive Review on Dry Eye Syndrome." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 1666–89. https://doi.org/10.5281/zenodo.12800567.

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Dry Eye Disease (DED) is a multifactorial condition of the ocular surface characterized by a loss of homeostasis of the tear film. It manifests with symptoms of discomfort, visual disturbance, and tear film instability. Understanding the complexities of DED is crucial for effective diagnosis and management. This review aims to provide a comprehensive overview of DED, including its causes, current treatments, and future research directions. It addresses the impact of surgical interventions, non-pharmacological therapies, complementary and alternative medicine (CAM), and the overall quality of l

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Schlegel, Irina, Claire M. F. De Goüyon Matignon de Pontourade, Joel-Benjamin Lincke, Irene Keller, Martin S. Zinkernagel, and Denise C. Zysset-Burri. "The Human Ocular Surface Microbiome and Its Associations with the Tear Proteome in Dry Eye Disease." International Journal of Molecular Sciences 24, no. 18 (2023): 14091. http://dx.doi.org/10.3390/ijms241814091.

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Although dry eye disease (DED) is one of the most common ocular surface diseases worldwide, its pathogenesis is incompletely understood, and treatment options are limited. There is growing evidence that complex interactions between the ocular surface microbiome (OSM) and tear fluid constituents, potentially leading to inflammatory processes, are associated with ocular surface diseases such as DED. In this study, we aimed to find unique compositional and functional features of the OSM associated with human and microbial tear proteins in patients with DED. Applying whole-metagenome shotgun seque

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Almulhim, Abdulmohsen. "Therapeutic Targets in the Management of Dry Eye Disease Associated with Sjögren’s Syndrome: An Updated Review of Current Insights and Future Perspectives." Journal of Clinical Medicine 13, no. 6 (2024): 1777. http://dx.doi.org/10.3390/jcm13061777.

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Dry eye disease (DED) is a continuing medical challenge, further worsened in the autoimmune inflammatory hyperactivation milieu of Sjögren’s syndrome (SS) due to disturbances to innate and adaptive immunity with malfunctioning neuro-endocrine control. However, the pathogenetic mechanisms of SS DED are not fully established. This review summarized the available evidence, from systematic reviews, meta-analyses, and randomized clinical trials, for the efficacy and safety of the available ocular therapeutics for the management of SS DED. Relevant studies were obtained from major databases using ap

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Macklin, Philip S., Rachel Fisher, Christopher Stonard, Rubeta N. Matin, and Eleni Ieremia. "Skin-Limited, Methotrexate-Associated Epstein–Barr Virus–Positive Mucocutaneous Ulcer—A Mimicker of High-Grade Lymphoma. A Report of 4 Cases and Review of the Literature." American Journal of Dermatopathology 45, no. 8 (2023): 519–31. http://dx.doi.org/10.1097/dad.0000000000002419.

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Abstract: Immunodeficiency-associated lymphoproliferative disorders (IA-LPDs) constitute a diverse range of conditions including posttransplant lymphoproliferative disorders, other iatrogenic IA-LPDs, and lymphoproliferative disorders associated with an underlying primary immune disorder or HIV infection. IA-LPDs are clinically and pathologically heterogeneous, and there is a lack of standardization of diagnostic terminology. They can represent a potential serious diagnostic pitfall because the histological features of clinically indolent proliferations may mimic those of high-grade lymphoma.

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Petriček, Igor, Martina Tomić, Tomislav Bulum, Dina Lešin Gaćina, and Sania Vidas Pauk. "Meibomian Gland Assessment in Routine Ophthalmology Practice." Metabolites 13, no. 2 (2023): 157. http://dx.doi.org/10.3390/metabo13020157.

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This cross-sectional study aimed to investigate the connection between meibomian gland (MG) excreta quantity and quality after MG expression (MGX), dry eye disease (DED) symptoms, and objective DED signs and to clarify the relationship between dry eye and MG function in DED pathophysiology. The study included 200 subjects, 100 with and 100 without dry eye symptoms. Schein questionnaire was used to determine the severity of dry eye symptoms and self-reported skin type for facial skin dryness self-evaluation. Objective dry eye signs were assessed by monitoring conjunctival hyperemia, lid paralle

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Ranđelović, Karla, Tomislav Jukić, Andrea Tešija Kuna, et al. "Hashimoto’s Thyroiditis and Dry Eye Disease." Journal of Clinical Medicine 14, no. 5 (2025): 1710. https://doi.org/10.3390/jcm14051710.

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Hashimoto’s thyroiditis (HT) is an autoimmune thyroid disease with characteristic lymphocytic infiltration and fibrosis. Chronic autoimmune changes that occur in the thyroid gland in HT may also affect the lacrimal gland. Objectives: This study aimed to analyze tear biomarkers and explore correlations between these biomarkers and clinical ocular parameters in patients with HT. Methods: A total of 150 participants were divided into three groups: HT (N = 50), non-HT DED (N = 50), and healthy controls (N = 50). The participants underwent a series of diagnostic tests for DED, including the Ocular

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Nocco, Sarah, and Cynthia Magro. "Primary Cutaneous Methotrexate-Associated T-Cell Lymphoproliferative Disorder in the Setting of Autoimmune Disease: A Case Series and Review of the Literature." American Journal of Dermatopathology 47, no. 2 (2025): 145–52. https://doi.org/10.1097/dad.0000000000002905.

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Abstract: Methotrexate (MTX), an antimetabolite targeting certain autoimmune conditions and various hematologic malignancies, has been associated with iatrogenic lymphoproliferative disease (LPD) primarily of B-cell lineage. Less commonly are T-cell neoplasms where primary skin involvement is considered rare. Three cases were encountered in the medical practice of one of the authors. The patients ranged in age from 38 years to 99 years (2 women and 1 man) with 2 having rheumatoid arthritis and 1 having ankylosing spondylitis. All 3 patients received MTX. The cases included subcutaneous periphe

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Petriček, Igor, Dina Lešin Gaćina, Martina Tomić, Tomislav Bulum, Iva Bešlić, and Sania Vidas Pauk. "Post-Blink Blur Time—A Simple Test to Detect Dry Eye-Related Visual Disturbances." Journal of Clinical Medicine 13, no. 9 (2024): 2473. http://dx.doi.org/10.3390/jcm13092473.

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Background: Dry eye disease (DED) stands out as one of the most common eye conditions encountered in clinical settings. This study aimed to determine the diagnostic ability and feasibility of post-blink blur time (PBBT) in detecting patients with DED symptoms. Methods: The study included 200 subjects, 100 with and 100 without DED symptoms defined by the Schein questionnaire, who underwent assessment of DED signs [visual acuity, PBBT, conjunctival hyperemia, lid-parallel conjunctival folds—LIPCOF, tear film break-up time—TBUT, fluorescein corneal staining, and meibum score]. Results: DED subjec

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K Abu, Emmanuel, Amanfo O Ofori, Samuel B Boadi-Kusi, et al. "Dry eye disease and meibomian gland dysfunction among a clinical sample of type 2 diabetes patients in Ghana." African Health Sciences 22, no. 1 (2022): 293–302. http://dx.doi.org/10.4314/ahs.v22i1.36.

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Objective: To evaluate dry eye disease and meibomian gland dysfunction among type 2 diabetes patients Methods: A hospital-based cross-sectional study was conducted. Parameters assessed included meibum expressibility and quality, Schirmer test 1, tear breakup time (TBUT), ocular surface staining, blink rates and Ocular Surface Disease Index (OSDI) scores. Dry eye was diagnosed based on a combination of subjective symptoms, tear function and ocular surface staining. Results: Prevalence of DED and MGD were 72.3% and 55.3% respectively. Symptomatic dry eye (OSDI scores) was significant

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Zhang, Peng-Cheng, Ya-Zhen Wu, Han-Jing Dai, Dan Wang, Yu-Meng Bao, and Hong Yan. "Influencing factors of ocular pain in dry eye disease patients at high altitude." International Journal of Ophthalmology 17, no. 12 (2024): 2214–20. http://dx.doi.org/10.18240/ijo.2024.12.08.

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AIM: To quantify the severity and frequency of ocular pain in Tibetan plateau patients with dry eye, and to evaluate the related factors affecting ocular pain. METHODS: A retrospective study included 160 cases of dry eye disease (DED) patients who were treated from July 2022 to June 2023. Age, gender, occupation, illness course, anxiety, plateau duration, plateau protection, ocular surface disease index scale (OSDI), break-up time (BUT), Schirmer I test (SIT), conjunctivitis, history of ophthalmic medication, autoimmune disease, the workload of daily near vision range, smoking and overnight st

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Singbartl, K., R. Murugan, A. M. Kaynar, et al. "Intensivist-Led Management of Brain-Dead Donors Is Associated with an Increase in Organ Recovery for Transplantation." American Journal of Transplantation 11, no. 7 (2011): 1517–21. http://dx.doi.org/10.1111/j.1600-6143.2011.03485.x.

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Kalalas, Charalampos, Linus Thrybom, and Jesús Alonso-Zárate. "Cellular Communications for Smart Grid Neighborhood Area Networks: A Survey." IEEE Access 4 (April 1, 2016): 1469–93. https://doi.org/10.1109/ACCESS.2016.2551978.

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This paper surveys the literature related to the evolution of cellular communications as a key enabling technology for fundamental operations of smart grid neighborhood area networks (NANs). The latest releases of the LTE standard, representing the recent advancements in cellular technology, offer significant benefits to the modernization of the aging power distribution grid compared with other communication technologies. However, since LTE was not originally designed for smart grid applications, important challenges remain unsolved before it can efficiently support advanced NAN functionalitie

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Paul, T. S. H., and N. J. Ledgard. "Vegetation succession associated with wilding conifer removal." New Zealand Plant Protection 62 (August 1, 2009): 374–79. http://dx.doi.org/10.30843/nzpp.2009.62.4878.

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Techniques used to remove unwanted wilding conifers can impact on subsequent vegetation successions Five South Island sites were assessed for vegetation successions after conifers had been removed by four methods felled to waste mulched harvested or killed standing by stem poisoning Felled conifers created a flush of vigorous plant growth but this increase was not longlasting and the end result was reduced plant biodiversity Mulching reduced all plant cover initially but gave poor wilding control Harvesting led to a dominance of exotics including wildings whereas solely native plants were foun

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Ben-Eli, Hadas, Shimon Perelman, Denise Wajnsztajn, and Abraham Solomon. "Evaluating Magnetic Stimulation as an Innovative Approach for Treating Dry Eye Disease: An Initial Safety and Efficacy Study." Biomedicines 13, no. 5 (2025): 1064. https://doi.org/10.3390/biomedicines13051064.

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Objective: The aim of this study was to assess the safety and preliminary efficacy of repetitive magnetic stimulation (RMS) as a treatment intervention for dry eye disease (DED), focusing on symptom reduction. Methodology: This investigation involved 22 adult participants (85% females, aged between 22 and 79 years) diagnosed with moderate-to-severe DED. These individuals were subjected to RMS treatment targeting one or both eyes using the VIVEYE-Ocular Magnetic Neurostimulation System version 1.0 (Epitech-Mag LTD; National Institute of Health (NIH) clinical trials registry #NCT03012698). A pla

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Yadav, Siddhartha, Marcy Richardson, Rachid Karam, et al. "Breast cancer risk associated with missense variants in BRCA2." Journal of Clinical Oncology 41, no. 16_suppl (2023): 10501. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.10501.

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10501 Background: Greater than 90% of missense variants in BRCA2 are classified as variants of uncertain significance (VUS). In addition, among the few known missense pathogenic variants (PVs) in BRCA2, breast cancer risk has been reported to be lower compared to pathogenic truncating variants (PTVs) (Li et al., 2022) . Herein, we aim to reclassify several missense variants in BRCA2 and investigate the associated breast cancer risk. Methods: A total of 450 BRCA2 missense variants in the C-terminal DNA binding domain (DBD) were evaluated for functional effect utilizing a previously validated ho

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Schachter-Tokarz, Esther, Bruno Cassinat, Charikleia Kelaidi та ін. "Uncommon Mutations in PML-RARα Associated with Poor Outcome after First Relapse in APL." Blood 110, № 11 (2007): 4248. http://dx.doi.org/10.1182/blood.v110.11.4248.4248.

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Abstract Background. Mutations in the RARα-region ligand binding domain (LBD) of PML-RARα were detected in 30 – 40% of patients (pts) tested after first relapse from ATRA-chemotherapy (CT) regimens in 2 North American Phase III trials. However, no follow-up data were reported to assess whether this affected subsequent outcome. Methods. In the current study, 8 relapse pts were tested by previously-published techniques for PML-RARα LBD mutations after relapse from ATRA-CT regimens of the EAG. Treatment was according to the APL2000 protocol: randomization to induction with ATRA+DNR with AraC (arm

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Magaña, Mario, María Fernanda Vargas Bornacini, Ana Paula Landeta-Sa, and Cristina Aguilar-Mena. "Lucio Phenomenon: a Review." American Journal of Dermatopathology 47, no. 1 (2024): 1–8. https://doi.org/10.1097/dad.0000000000002833.

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Abstract: Mycobacterium leprae and M. lepromatosis, the causative agents of leprosy, have left a mark on human history. Despite advances in health care, leprosy continues to affect millions worldwide, often leading to complications, mostly neural, due to delayed diagnosis and treatment. This persisting prevalence emphasizes the need for continued research and effective management strategies. Leprosy presents in many forms, mainly lepromatous and tuberculoid, influenced by the patient's immunological status and exhibits specific clinical characteristics. Studies have shown that Mycobacterium le

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Matsushita, A., H. Misawa, S. Andoh, et al. "Very strong correlation between dominant negative activities of mutant thyroid hormone receptors and their binding avidity for corepressor SMRT." Journal of Endocrinology 167, no. 3 (2000): 493–503. http://dx.doi.org/10.1677/joe.0.1670493.

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The syndrome of resistance to thyroid hormone (RTH) is an inherited disorder involving a mutation of the thyroid hormone receptor (TR) gene. Mutant (m) TR inhibits wild-type (wt) TR functions in a dominant negative manner, and this dominant negative effect (DNE) is a crucial factor in RTH pathogenesis. The molecular mechanism of the DNE is still unclear, although several possibilities (including competition between wt- and mTRs at the T(3) response element (TRE), sequestration of TR-associated protein(s) and titration out of functional TR) have been considered. Here we report that the DNE of m

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Zhang, Xian, Saowaluck Tibpromma, Samantha C. Karunarathna, et al. "Additions to the saprobic fungi (Ascomycota) associated with macadamia trees from the Greater Mekong Subregion." MycoKeys 113 (January 24, 2025): 1–29. https://doi.org/10.3897/mycokeys.113.140031.

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Macadamia trees, the most economically important Proteaceae perennial crop, are globally renowned for their edible nuts. During our surveys of microfungi associated with macadamia in China and Thailand, we isolated three saprobic fungi from dead macadamia branches. Our multigene phylogenetic analyses (ITS, LSU, SSU, tef1-α, TUB2, and ACT loci), genealogical concordance phylogenetic species recognition (GCPSR) with a pairwise homoplasy index (PHI) test, and morphological characteristics led to the discovery of two new species, Dothiorella macadamiae and Phaeoacremonium chiangmaiense, and one ne

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Pandey, Sumali, Scott A. Hoselton, and Jane M. Schuh. "The Impact ofAspergillus fumigatusViability and Sensitization to Its Allergens on the Murine Allergic Asthma Phenotype." BioMed Research International 2013 (2013): 1–17. http://dx.doi.org/10.1155/2013/619614.

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Aspergillus fumigatusis a ubiquitously present respiratory pathogen. The outcome of a pulmonary disease may vary significantly with fungal viability and host immune status. Our objective in this study was (1) to assess the ability of inhaled irradiation-killed or liveA. fumigatusspores to induce allergic pulmonary disease and (2) to assess the extent to which inhaled dead or liveA. fumigatusspores influence pulmonary symptoms in a previously established allergic state. Our newly developed fungal delivery apparatus allowed us to recapitulate human exposure through repeated inhalation of dry fun

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Zhang, Xian, Saowaluck Tibpromma, Samantha C. Karunarathna, et al. "Additions to the saprobic fungi (Ascomycota) associated with macadamia trees from the Greater Mekong Subregion." MycoKeys 113 (January 24, 2025): 1–29. https://doi.org/10.3897/mycokeys.113.140031.

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Macadamia trees, the most economically important Proteaceae perennial crop, are globally renowned for their edible nuts. During our surveys of microfungi associated with macadamia in China and Thailand, we isolated three saprobic fungi from dead macadamia branches. Our multigene phylogenetic analyses (ITS, LSU, SSU, <i>tef</i>1-α, <i>TUB</i>2, and <i>ACT</i> loci), genealogical concordance phylogenetic species recognition (GCPSR) with a pairwise homoplasy index (PHI) test, and morphological characteristics led to the discovery of two new species, <i>Dothiorella macadamiae</i> and <i>Phaeoacrem

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Beekman, Christopher S. "THE CHRONOLOGICAL CONTEXT OF THE CENTRAL JALISCO SHAFT TOMBS." Ancient Mesoamerica 17, no. 2 (2006): 239–49. http://dx.doi.org/10.1017/s0956536106060111.

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The shaft tomb mortuary tradition is an archaeological construct that encompasses a diverse array of burial practices, many of which now seem to reflect local variations in specific treatments of the dead. Distinctive characteristics of shaft tombs in the Tequila valleys of central Jalisco include the high degree of labor invested in tomb construction, the wealth of offerings found within the tombs, and the occasional association of the tombs with the circular public architecture known as the Teuchitlan tradition. These characteristics have led some researchers to see the Tequila valleys as th

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Rofaie, Nina Sakinah Ahmad, Seuk Wai Phoong, and Muzalwana Abdul Talib @ Abdul Mutalib. "Light-Emitting Diode (LED) versus High-Pressure Sodium Vapour (HPSV) Efficiency: A Data Envelopment Analysis Approach with Undesirable Output." Energies 15, no. 13 (2022): 4589. http://dx.doi.org/10.3390/en15134589.

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Road lighting is essential to ensure the safety and comfort of its users, especially in preventing accidents and aiding visual tasks. The monumental shift from conventional road lighting technology to light-emitting diode (LED) lighting is driven by energy efficiency, associated cost savings, and environmental concerns in the road lighting system. This study aims to investigate the performance of LED in substitution for high-pressure sodium vapour (HPSV) road lighting in Penang Bridge, Malaysia using the Data Envelopment Analysis (DEA), a frontier-based optimisation approach, by modelling ener

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Puri, Randhir, Yoginder Singh, K. Anand Shankar, Arun Tyagi, S. Rohatgi, and AM Jagadish. "Postpartum Respiratory Failure." Journal of South Asian Federation of Obstetrics and Gynaecology 2, no. 1 (2010): 73–75. http://dx.doi.org/10.5005/jp-journals-10006-1068.

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ABSTRACT This is a case report of a 29 years old primigravida who at 32 weeks of gestation presented with severe pain abdomen and backache. She had a massive concealed placental abruption that led intrauterine fetal death. Due to the progressively deteriorating maternal condition a cesarean section was performed under general anesthesia to deliver the dead fetus. After five days the patient developed acute respiratory failure and needed mechanical ventilation. The common causes of respiratory failure associated with pregnancy are discussed.

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Shirnekhi, Hazheen K., Bappaditya Chandra, and Richard W. Kriwacki. "Dissolving Fusion Oncoprotein Condensates to Reverse Aberrant Gene Expression." Cancer Research 83, no. 20 (2023): 3324–26. http://dx.doi.org/10.1158/0008-5472.can-23-2769.

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Abstract In a recent study, Wang and colleagues reported that a significant fraction of cancer-associated fusion proteins display a common structural topology, including an N-terminal phase separation-prone region (PS) from one parent protein and a C-terminal DNA-binding domain (DBD) from the other. This is reminiscent of the structural topology of transcription factors and led to the hypothesis that the PS-DBD fusions form aberrant transcriptional condensates through phase separation, which was supported through transcriptomic data analysis and cellular condensate assays. The authors develope

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Magraht, Carolina, Fabiana B. Mazzei, Silvina Verna, María Eugenia Paradeda, Andrea Paes De Lima, and Manuel R. Montesinos. "Positive sentinel lymph node in melanoma: predictive factors and results of completion lymph node dissection." Revista Argentina de Cirugía 114, no. 4 (2022): 299–306. http://dx.doi.org/10.25132/raac.v114.n4.1622.

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Background: Sentinel lymph node (SLN) biopsy is the technique accepted to determine the prognosis of early cutaneous melanomas. The advantage of lymph node dissection (LND) when SLN biopsy is positive has recently been questioned. Objective: The aim of this study is to describe the percentages and factors associated with SLN and non-sentinel node (NSN) metastases in LNDs of SLN-positive patients. Material and methods: The clinical records and pathology reports of 139 patients undergoing surgery for cutaneous melanoma between January 2012 and December 2019 were retrospectively reviewed. Results

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Prakash, Uttam, Yasir Mohammad, and Vivek Kumar. "Ocular Side Effects of Medications for Anxiety, Depression, and Stress: A Review." International Journal of Medical and Biomedical Studies 8, no. 5 (2024): 101–10. http://dx.doi.org/10.32553/ijmbs.v8i5.2899.

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Background: The COVID-19 pandemic has led to a global rise in mental health disorders, prompting increased usage of psychotropic medications. This study examines the ocular side effects associated with these medications in patients diagnosed with anxiety, depression, and stress-related disorders. Methods: A total of 100 patients were enrolled in this one-year study conducted at ESIC Medical College & Hospital, Bihta, Patna. Ocular evaluations were performed to assess the prevalence of dry eye disease (DED), mydriasis, elevated intraocular pressure (IOP), and other ocular complications of p

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Murata, O., K. Suzuki, N. Sasaki, T. Takeuchi, and M. Maemondo. "FRI0497 THERAPEUTIC STRATEGIES AND LONG-TERM OUTCOME IN PATIENTS WITH INTERSTITIAL PNEUMONIA WITH AUTOIMMUNE FEATURES: A SINGLE CENTER LARGE-SCALE OBSERVATIONAL COHORT STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 846.2–847. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4334.

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Background:Patients with idiopathic interstitial pneumonia (IIP) may have features of connective tissue diseases (CTDs). The term interstitial pneumonia with autoimmune features (IPAF) has been recently proposed for such patients [1]. To date, only few studies have comprehensively described outcomes over a long-term period and choices of treatment [2-4].Objectives:The aim of this study was to investigate the therapeutic strategies and long-term outcome among patients with IPAF, IIP, and CTD-ILD.Methods:Six hundreds- and seventy-two patients who had visited our department between April 2009 and

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Liu, Xiaochang, Jiuxia Pang, Christopher Seiler, et al. "DNA Cytosine-Demethylating Agent 5-Aza-2'-Deoxycytidine Targets Leukemia Cells through Reducing DNA N6-Methyladenine." Blood 134, Supplement_1 (2019): 2513. http://dx.doi.org/10.1182/blood-2019-130490.

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Introduction: It is known that overexpression of DNA methyltransferases (e.g., DNMT1) is frequent and changes of DNA cytosine methylation (5mC) are a constant feature of cancers. DNA methylation inhibitors, such as 5-aza-2'-deoxycytidine (Dec), have been in clinics for patients with leukemia. It is classically believed that promoter hypomethylation coupled by reexpression of epigenetically-suppressed tumor suppressors is a core mechanism behind Dec-impaired leukemia cell growth. However, the fact that global DNA methylation profiling barely predicts Dec-response suggests a demethylation-indepe

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Zhao, Hong-Ying, and Jing-Min Cheng. "Associations between ambient temperature and acute myocardial infarction." Open Medicine 14, no. 1 (2018): 14–21. http://dx.doi.org/10.1515/med-2019-0003.

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AbstractBackgroundThe associations between incidence of acute myocardial infarction (AMI) and the ambient temperature were mixed in prior studies.MethodsData of 2033 consecutive admissions of AMI in a central tertiary hospital in North China from 1st Jan 2003 to 31st Dec 2011 were collected. The weather data in this period were from the local meteorological department. Based on the ambient temperature information, we defined several ambient temperature indices, including daily average temperature, extremely low temperature, and daily temperature range, then characterized the independent associ

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Beaulac, Kirthana, Silvia Corcione, Lauren Epstein, Lisa E. Davidson, and Shira Doron. "Antimicrobial Stewardship in a Long-Term Acute Care Hospital Using Offsite Electronic Medical Record Audit." Infection Control & Hospital Epidemiology 37, no. 4 (2016): 433–39. http://dx.doi.org/10.1017/ice.2015.319.

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OBJECTIVETo offer antimicrobial stewardship to a long-term acute care hospital using telemedicine.METHODSWe conducted an uninterrupted time-series analysis to measure the impact of antimicrobial stewardship on hospital-acquired Clostridium difficile infection (CDI) rates and antimicrobial use. Simple linear regression was used to analyze changes in antimicrobial use; Poisson regression was used to estimate the incidence rate ratio in CDI rates. The preimplementation period was April 1, 2010–March 31, 2011; the postimplementation period was April 1, 2011–March 31, 2014.RESULTSDuring the preimpl

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Pavlov, Igor N., Rimvydas Vasaitis, Yulia A. Litovka, Anton A. Timofeev, and Audrius Menkis. "Infestation by Ips amitinus (Eichhoff, 1872), Its Associated Fungi, and Butt Rots in Stands of Pinus sibirica in South-Western Siberia." Forests 14, no. 12 (2023): 2383. http://dx.doi.org/10.3390/f14122383.

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In 2019, the bark beetle Ips amitinus (native to central Europe) was identified in south-western Siberia at a distance exceeding 2500 km east of its previously known easternmost location in the European part of Russia. In Siberia, its invasive populations are characterised by high abundance and harmfulness. Here, I. amitinus accomplishes primary attacks on standing vital trees of Pinus sibirica with a lethal outcome. This invasion has already resulted in massive dieback in stands of pine over a large geographic territory. By, 2021, the invaded area was estimated to cover at least 31,200 km2. T

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Leung, Thomas, Xiang-Qun Chen, Ivan Tan, Edward Manser, and Louis Lim. "Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Acts as a Cdc42 Effector in Promoting Cytoskeletal Reorganization." Molecular and Cellular Biology 18, no. 1 (1998): 130–40. http://dx.doi.org/10.1128/mcb.18.1.130.

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ABSTRACT The Rho GTPases play distinctive roles in cytoskeletal reorganization associated with growth and differentiation. The Cdc42/Rac-binding p21-activated kinase (PAK) and Rho-binding kinase (ROK) act as morphological effectors for these GTPases. We have isolated two related novel brain kinases whose p21-binding domains resemble that of PAK whereas the kinase domains resemble that of myotonic dystrophy kinase-related ROK. These ∼190-kDa myotonic dystrophy kinase-related Cdc42-binding kinases (MRCKs) preferentially phosphorylate nonmuscle myosin light chain at serine 19, which is known to b

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Hyo, Rie, Yasunobu Abe, Kisato Nosaka, et al. "Proposal of Progressive Adult Onset EBV-Associated Lymphoproliferative Disorder (PAEBV) as a Rapid-Onset Neoplastic Disease." Blood 114, no. 22 (2009): 2920. http://dx.doi.org/10.1182/blood.v114.22.2920.2920.

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Abstract Abstract 2920 Poster Board II-896 [Background] Epstein-Barr virus (EBV) is currently recognized as a pathogen of several known human diseases ranging from transient infection, chronic lymphoproliferative disorder (LPD) to EBV-positive malignant lymphomas. Chronic active EBV infection (CAEBV) is typically an indolent but long-lasting EBV-LPD of childhood. Another well documented EBV-associated LPD is the post-transplant EBV-LPD, which also occurs in adults. Fulminant proliferation of EBV after primary infection or in the setting of CAEBV is an aggressive type of disease, which has rece

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Jossier, Mathieu, Yanpei Liu, Sophie Massot, and Michael Hodges. "Enzymatic Properties of Recombinant Phospho-Mimetic Photorespiratory Glycolate Oxidases from Arabidopsis thaliana and Zea mays." Plants 9, no. 1 (2019): 27. http://dx.doi.org/10.3390/plants9010027.

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In photosynthetic organisms, the photorespiratory cycle is an essential pathway leading to the recycling of 2-phosphoglycolate, produced by the oxygenase activity of ribulose-1,5-bisphosphate carboxylase/oxygenase, to 3-phosphoglycerate. Although photorespiration is a widely studied process, its regulation remains poorly understood. In this context, phosphoproteomics studies have detected six phosphorylation sites associated with photorespiratory glycolate oxidases from Arabidopsis thaliana (AtGOX1 and AtGOX2). Phosphorylation sites at T4, T158, S212 and T265 were selected and studied using Ar

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Battle, Allen O., Mary V. Battle, and Elizabeth A. Tolley. "Potential for Suicide and Aggression in Delinquents at Juvenile Court in a Southern City." Suicide and Life-Threatening Behavior 23, no. 3 (1993): 230–44. http://dx.doi.org/10.1111/j.1943-278x.1993.tb00182.x.

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Because juvenile delinquents rarely communicate their wishes for suicide or homicide appropriately to busy caretakers, some means to identify those juveniles at greatest risk of acting out was sought. Psychological examiners in a Southern city individually questioned 263 Juvenile Court offenders about whether they wished to be dead, to kill themselves, or to kill others; and also about their existential experiences, thoughts and feelings. Taking the data associated with each wish, we used stepwise multiple logistic regression to pinpoint experiences, such as substance abuse, that were associat

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Dima, Shinechimeg, Yin-Yin Lee, Ikki Watanabe, Wei-Jen Chang, Yu-Hua Pan та Nai-Chia Teng. "Antibacterial Effect of the Natural Polymer ε-Polylysine Against Oral Pathogens Associated with Periodontitis and Caries". Polymers 12, № 6 (2020): 1218. http://dx.doi.org/10.3390/polym12061218.

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Antimicrobials are important adjuncts in the treatment of caries and periodontitis. However, increased bacterial resistance and hypersensitivity reactions to commonly used antimicrobials have led to an increasing demand for safe and natural substances. The objective of this study was to investigate the antibacterial effects of ε-polylysine against oral pathogens Streptococcus mutans and Porphyromonas gingivalis. Broth dilution assay, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM) analyses were performed to explore the antibacterial effect of ε-polylysine again

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Balhaddad, Abdulrahman A., Mohammed S. AlQranei, Maria S. Ibrahim, et al. "Light Energy Dose and Photosensitizer Concentration Are Determinants of Effective Photo-Killing against Caries-Related Biofilms." International Journal of Molecular Sciences 21, no. 20 (2020): 7612. http://dx.doi.org/10.3390/ijms21207612.

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Caries-related biofilms and associated complications are significant threats in dentistry, especially when biofilms grow over dental restorations. The inhibition of cariogenic biofilm associated with the onset of carious lesions is crucial for preventing disease recurrence after treatment. This in vitro study defined optimized parameters for using a photosensitizer, toluidine blue O (TBO), activated via a red light-emitting diode (LED)-based wireless device to control the growth of cariogenic biofilms. The effect of TBO concentrations (50, 100, 150, and 200 μg/mL) exposed to light or incubated

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Yajima, Hirohiko, Kyung-Jong Lee, and Benjamin P. C. Chen. "ATR-Dependent Phosphorylation of DNA-Dependent Protein Kinase Catalytic Subunit in Response to UV-Induced Replication Stress." Molecular and Cellular Biology 26, no. 20 (2006): 7520–28. http://dx.doi.org/10.1128/mcb.00048-06.

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ABSTRACT Phosphorylation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) upon ionizing radiation (IR) is essential for cellular radioresistance and nonhomologous-end-joining-mediated DNA double-strand break repair. In addition to IR induction, we have previously shown that DNA-PKcs phosphorylation is increased upon camptothecin treatment, which induces replication stress and replication-associated double-strand breaks. To clarify the involvement of DNA-PKcs in this process, we analyzed DNA-PKcs phosphorylation in response to UV irradiation, which causes replication stress and

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Tajmirriahi, Marzieh, Parisa Salari, and Mohammad Saadatnia. "Left atrial function index in embolic stroke of undetermined source: A case-control study." Neurology Asia 27, no. 2 (2022): 275–79. http://dx.doi.org/10.54029/2022cnz.

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Background & Objectives: Previous studies showed left atrial volume index (LAVi) is a precise surrogate of atrial cardiopathy and associated with new-onset atrial fibrillation and embolic stroke undetermined source (ESUS). Recent data suggest that the left atrial functional index (LAFi) is associated with the risk of developing AF recurrence. However, there was no study to show LAFi in ESUS. We aim to compare the performance of different surrogates of atrial cardiopathy (LAVi and LAFi) in a cohort of ESUS patients and healthy adults. Methods: Between Dec 2018 to Feb 2020, consecutive patie

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Popova, Blagovesta, Dan Wang, Christina Pätz та ін. "DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization". PLOS Genetics 17, № 3 (2021): e1009407. http://dx.doi.org/10.1371/journal.pgen.1009407.

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Parkinson’s disease is a neurodegenerative disorder associated with misfolding and aggregation of α-synuclein as a hallmark protein. Two yeast strain collections comprising conditional alleles of essential genes were screened for the ability of each allele to reduce or improve yeast growth upon α-synuclein expression. The resulting 98 novel modulators of α-synuclein toxicity clustered in several major categories including transcription, rRNA processing and ribosome biogenesis, RNA metabolism and protein degradation. Furthermore, expression of α-synuclein caused alterations in pre-rRNA transcri

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Ruf, Marie-Thérèse, Daniela Schütte, Aurélie Chauffour, Vincent Jarlier, Baohong Ji, and Gerd Pluschke. "Chemotherapy-Associated Changes of Histopathological Features of Mycobacterium ulcerans Lesions in a Buruli Ulcer Mouse Model." Antimicrobial Agents and Chemotherapy 56, no. 2 (2011): 687–96. http://dx.doi.org/10.1128/aac.05543-11.

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ABSTRACTCombination chemotherapy with rifampin and streptomycin (RIF-STR) for 8 weeks is currently recommended by the WHO as the first-line treatment forMycobacterium ulceransinfection (Buruli ulcer). To gain better insight into the mode of action of these antibiotics against establishedM. ulceransinfection foci and to characterize recovery of local immune responses during chemotherapy, we conducted a detailed histopathological study ofM. ulcerans-infected and RIF-STR-treated mice. Mice were inoculated withM. ulceransin the footpad and 11 weeks later treated with RIF-STR. Development of lesion

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Jin, Liang Jie, Cheng Hong Liang, Yong Zhang, and Zhi Yong Li. "HPLC Method for Bacillamide C Analysis in the Metabolites of a Bacillus atrophaeus Strain." Advanced Materials Research 926-930 (May 2014): 1001–4. http://dx.doi.org/10.4028/www.scientific.net/amr.926-930.1001.

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A new HPLC method for the analysis of bacillamide C, with DAD detector at 220nm, has been developed, validated and used in the EtOAC extracts of the fermentation broth of a Bacillus atrophaeus strain, associated with the South China Sea sponge Dysidea avara. Bacillamide C was well quantified on a reversed phase ZORBAX Eclipse XDB-C18 column by use of a gradient mobile phase from 20% (v/v) acetonitrile to 45% (v/v) acetonitrile in 15 min at a flow rate of 1 mL/min. The linearity ranges were 1.00-1000.00μg/mL with values of LOD (limit of detection) equal to 0.15μg/mL. The HPLC method was proved

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Patwary, Masum A., and Mosharraf H. Sarker. "Quantitative assessment of mortuary waste: occupational safety and environmental health." Journal of Hospital Administration 1, no. 1 (2012): 49. http://dx.doi.org/10.5430/jha.v1n1p49.

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Mismanagement of mortuary waste is a significant risk factor for disease transmission. Quantitative estimation of mortuary waste generation is needed to estimate the potential risk and as a basis for any waste treatment, disposal and management plan. Bangladesh, a developing country, is an example where there has been no rigorous estimation of mortuary waste generation and associated risk factors based on a thorough scientific study. The present study used a statistically designed sampling method of waste generation in a broad range to identify the factors associated with public health and env

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Grushevenko, Evgenia, Tatiana Rokhmanka, Stepan Sokolov, et al. "Influence of Type of Cross-Linking Agent on Structure and Transport Properties of Polydecylmethylsiloxane." Polymers 15, no. 22 (2023): 4436. http://dx.doi.org/10.3390/polym15224436.

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The development of membrane materials with high transport and separation properties for the removal of higher hydrocarbons from gas mixtures is an important and complex task. This work examines the effect of a cross-linking agent on the structure and transport properties of polydecylmethylsiloxane (C10), a material characterized by high selectivity towards C3+ hydrocarbons. C10 was cross-linked with various diene hydrocarbons, such as 1,7-octadiene (C10-OD), 1,9-decadiene (C10-DD), 1,11-dodecadiene (C10-DdD), and vinyl-terminated polysiloxanes, of different molecular weights: 500 g/mol (C10-Si

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Kljaković-Gašpić, Zorana, Snježana Herceg Romanić, Darija Klinčić, and Vjekoslav Tičina. "Chlorinated compounds in the muscle tissue of fish from the Croatian Adriatic: preliminary data on contamination and the associated health risks / Klorirani spojevi u mišićnom tkivu riba iz istočnog Jadranskog mora: preliminarni podaci o zagađenosti i zdravstvenim rizicima." Archives of Industrial Hygiene and Toxicology 66, no. 4 (2015): 299–308. http://dx.doi.org/10.1515/aiht-2015-66-2667.

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Levels of 17 polychlorinated biphenyl congeners (PCBs) and seven organochlorine pesticides (OCPs) were measured in the muscle tissue of 18 commercially important fish species from the eastern Adriatic Sea. PCBs [<LOD-8,866 ng g-1 lipid weight (lw)] accounted for over 66 % of all analysed compounds. Their pattern was dominated by PCB-138 and PCB-153. DDE (14.2-649 ng g-1 lw) was the prevalent DDT isomer in all samples, suggesting no recent DDT input. β-, γ- and α-HCH and HCB were found in less than 50 % of samples. The analysed organic contaminants did not seem to bioaccumulate up the food w

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Merry, Alan F. "The Professor Merry Lecture: Endings and Beginnings." Journal of ExtraCorporeal Technology 43, no. 1 (2011): P17—P22. http://dx.doi.org/10.1051/ject/201143p17.

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Organ transplantation has become an established and worthwhile treatment for many otherwise intractable conditions in many countries around the world. For example, over 4000 patients have benefited from heart or lung transplants (or both) since the first heart transplant in Australia or New Zealand was carried out in 1984. However, there is thought to be a worldwide shortage of donors relative to the number of organs needed. Many people, notably many of those involved with situations in which organ donation might be possible, value the opportunity to contribute organs. This has led to interest

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Puca, Valentina, Eva Ercolino, Christian Celia, et al. "Detection and Quantification of eDNA-Associated Bacterial Membrane Vesicles by Flow Cytometry." International Journal of Molecular Sciences 20, no. 21 (2019): 5307. http://dx.doi.org/10.3390/ijms20215307.

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Bacteria generate membrane vesicles, which are structures known as extracellular vesicles (EVs), reported to be involved in different pathogenic mechanisms, as it has been demonstrated that EVs participate in biofilm formation, cell-to-cell communication, bacteria–host interactions, and nutrients supply. EVs deliver nucleic acids, proteins, and polysaccharides. It has been reported that Helicobacter pylori (H. pylori) and Lactobacillus reuteri (L. reuteri), of both planktonic and biofilm phenotypes, produce EVs carrying extracellular DNA (eDNA). Here, we used polychromatic flow cytometry (PFC)

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Kim, Mugyeom. "Eschatological Paradigm in V. F. Odoevsky’s Short Story “The Dead Man’s Mocking”." Проблемы исторической поэтики 22, no. 3 (2024): 75–91. http://dx.doi.org/10.15393/j9.art.2024.14084.

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This article examines “The Dead Man’s Mocking” (1834), one of the inserted stories from V. F. Odoevsky’s novel “Russian Nights” (1844). The ethical and aesthetic aspects of this story are analyzed from the viewpoint of the eschatological paradigm. It demonstrates that thanks to this paradigm, driven by the author’s religious worldview, which permeates all his works and predetermines the author’s special attitude to philosophical and social topics, the ethical and aesthetic aspects also acquire a religious meaning. The absence of love in the heroine, named Lisa by the author and “diametrically”

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Pribus, Sophia, Maxine C. Umeh-Garcia, Bo Gu, et al. "Abstract PO5-06-01: Loss of hormone receptor expression in breast cancer is associated with increased brain tropism and accelerated progression of leptomeningeal disease." Cancer Research 84, no. 9_Supplement (2024): PO5–06–01—PO5–06–01. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-06-01.

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Abstract The four breast cancer subtypes—luminal A, luminal B, HER2-overexpressing, and triple-negative breast cancer (TNBC) – are classified based on gene expression profiles of hormone receptors (HRs) (estrogen receptor (ER) and progesterone receptor (PR)) and human epidermal growth factor receptor 2 (HER2/ERBB2). Negative hormone receptor status is known to be associated with more aggressive breast cancer. Compared to other breast cancer subtypes, the HR-negative TNBC and HER2-overexpressing subtypes are characterized by high rates of recurrence and a notable increase in brain metastases an

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