Relevant bibliographies by topics / Deep vein thrombosis (DVT)

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Deep vein thrombosis (DVT)'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Deep vein thrombosis (DVT)"

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Allen, Lisa, and Andrew Wilkinson. "Deep vein thrombosis." InnovAiT: Education and inspiration for general practice 13, no. 6 (March 31, 2020): 344–51. http://dx.doi.org/10.1177/1755738020911990.

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Deep vein thrombosis (DVT) is a common and serious condition with a substantial risk of morbidity and mortality for patients. A diagnosis of DVT affects both the physical health and psychosocial functioning of patients. It represents a significant cost to the NHS in both expenditure and resource allocation. Management should focus on early recognition, prompt referral and prevention of its associated complications. This article aims to provide relevant background knowledge about DVT with advice on assessment using a clinical risk tool and appropriate referral to secondary care.
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Denny, Nicholas, Shreshta Musale, Helena Edlin, Ferdinando Serracino-Inglott, and Jecko Thachil. "Chronic deep vein thrombosis." Acute Medicine Journal 17, no. 3 (July 1, 2018): 144–47. http://dx.doi.org/10.52964/amja.0719.

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Deep vein thrombosis (DVT) is an important cause of short-term mortality and long-term morbidity. Although acute DVT is often well managed, there is uncertainty in the management of chronic DVT which is increasingly being noted among patients presenting with similar symptoms to their initial DVT. The presence of a residual venous clot can be a problem for both physicians and patients fearing the risk of emboli to the same extent as the acute DVT. There are also issues in the accurate diagnosis and appropriate management of chronic DVT, which is the focus of the second part of this review.
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HOLCOMB, SUSAN SIMMONS. "Deep vein thrombosis (DVT)." Nursing 36, no. 10 (October 2006): 43. http://dx.doi.org/10.1097/00152193-200610000-00036.

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Cheema, Ali Akhtar, Robert H. Mallinson, and Nicola Trepte. "Advances in Deep Vein Thrombosis Management with Thrombolysis." Acute Medicine Journal 8, no. 2 (April 1, 2009): 63–69. http://dx.doi.org/10.52964/amja.0234.

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Lower extremity deep vein thrombosis (DVT) is a common disease associated with serious short term and long term complications. Its conventional treatment has been anticoagulation. Thrombolytic treatment has been used for DVT for over 40 years. More recently catheter directed thrombolysis has taken over systemic thrombolysis. This technique is useful to prevent post thrombotic syndrome (PTS) after DVT. In this review article we present a case of DVT thrombolysis in our hospital, look at the pathophysiology of PTS, the mechanism of thrombolysis and the current status of thrombolysis in DVT.
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Aabideen, Kanakkande, Michael Ogendele, Ijaz Ahmad, and Laweh Amegavie. "Deep vein thrombosis in children." Pediatric Reports 5, no. 2 (June 19, 2013): 12. http://dx.doi.org/10.4081/pr.2013.e12.

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We describe a rare case of deep vein thrombosis (DVT) in children, highlight the importance of early diagnosis of rare disease with potential complications. In a 5 year old boy presented with persistent leg pain without any obvious cause. Detailed investigation led to diagnosis of DVT. As there are common differential diagnoses for leg pain in children, pediatricians usually have a low index of suspicious of DVT in children. This case highlight that paediatricians must consider DVT in their differential diagnosis when children present with leg pain.
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Hardman, Rulon. "Management of Chronic Deep Vein Thrombosis in Women." Seminars in Interventional Radiology 35, no. 01 (March 2018): 003–8. http://dx.doi.org/10.1055/s-0038-1636514.

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AbstractChronic deep vein thrombosis (DVT) affects hundreds of thousands of women in the United States. Chronic DVT can lead to pain, edema, venous ulcers, and varicosities. While there are limited data regarding the management of chronic DVT, several interventional radiology groups aggressively treat chronic DVT to aid patient symptom resolution. Recanalization of occluded veins and venous stenting re-establishes deep vein flow and decreases venous hypertension.
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Endig, Heike, Franziska Michalski, and Jan Beyer-Westendorf. "Deep Vein Thrombosis – Current Management Strategies." Clinical Medicine Insights: Therapeutics 8 (January 2016): CMT.S18890. http://dx.doi.org/10.4137/cmt.s18890.

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Deep vein thrombosis (DVT) is a frequent and potentially life-threatening condition, and acute and late complications are common. The diagnostic approach to DVT needs to be reliable, widely available, and cost-effective. Furthermore, several therapeutic options are available for DVT treatment and the choice of anticoagulant drug, dosage, and treatment duration has to reflect the specific situation of the individual DVT patient. This review was aimed to provide bedside guidance for clinicians faced with common (and less common) clinical scenarios in DVT treatment.
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Joffe, Hylton, Nils Kucher, Victor Tapson, and Samuel Goldhaber. "Few predictors of massive deep vein thrombosis." Thrombosis and Haemostasis 94, no. 11 (2005): 986–90. http://dx.doi.org/10.1160/th05-05-0314.

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SummaryFactors that predispose to thrombus propagation from the femoropopliteal veins to the pelvic veins are poorly understood. Our goal was to determine whether there are characteristics that identify patients with massive deep vein thrombosis (DVT). We compared the 122 (2.5%) patients presenting with massive DVT (pelvic plus lower-extremity DVT) to the 4,674 (97.5%) patients with isolated lower-extremity DVT from a prospective United States multicenter DVT registry. Patients with massive DVT were younger (59.4±18.9 years vs. 64.3±16.8 years; p<0.01), less likely to have hypertension (40% vs. 51%; p=0.02), and more likely to smoke (21% vs. 13%; p=0.02) and have on- going radiation therapy (7% vs. 3%; p=0.02). The massive DVT group more commonly presented with extremity edema (80% vs. 69%; p<0.01) and erythema (21% vs. 12%; p<0.01) than the isolated lower-extremity DVT group. However, after multivariable logistic regression analysis, extremity erythema (adjusted odds ratio 1.86; 95% CI 1.13–3.04) was the only independent sequela of massive DVT and younger age (adjusted odds ratio 1.17 per decreasing decade of age; 95% confidence interval: 1.02-1.34) was the only independent predictor of massive DVT. Thrombus propagation from the femoropopliteal system cannot be reliably predicted using demographic or clinical characteristics.
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Paris, Samuel, Grégoire Le Gal, Jean-Pierre Laroche, Arnaud Perrier, Henri Bounameaux, and Marc Righini. "Clinical relevance of distal deep vein thrombosis." Thrombosis and Haemostasis 95, no. 01 (2006): 56–64. http://dx.doi.org/10.1160/th05-08-0588.

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SummaryThe standard diagnostic approach of suspected deep vein thrombosis (DVT) is serial lower limb compression ultrasound (CUS) of proximal veins. Although it only assesses the proximal veins, withholding anticoagulant treatment in patients with a negative CUS on day one and after one week has been proven to be safe. However, in many centres, distal DVT is systematically screened for and treated by anticoagulants. The objectives of the review were 1) to evaluate the rate of extension of distal DVTs to proximal veins 2) to compare the safety of proximal limited CUS versus single complete CUS. We performed a MEDLINE search covering the period from January 1983 to January 2005 by using the key-words “calf vein thrombosis”, “distal thrombosis” and “compression ultrasonography”. English, German and French language original studies were retrieved. Moreover, references of retrieved articles were screened in order to detect missed pertinent articles. We pooled data of management studies where proximal or complete (i. e. proximal and distal) CUS were used, respectively. Studies evaluating CUS limited to the proximal veins showed a good safety profile with a pooled estimate of the 3-month thromboembolic rate of 0.6% (95% CI: 0.4–0.9%) in patients in whom anticoagulation was withheld. Studies using proximal and distal CUS showed a similar pooled estimate of the 3-month thromboembolic rate (0.4%, 95% CI: 0.1–0.6%) but distal DVT accounted for as many as 50% of all diagnosed DVTs in those series. Therefore, searching for distal DVT potentially doubles the number of patients given anticoagulant therapy and entails a risk of over-treatment. Data suggesting that anticoagulation is indicated for distal DVT are limited, and realizing distal CUS entails a risk of over-treatment. There is an urgent need for randomised trials assessing the usefulness of anticoagulant treatment in distal DVT.
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Kyrle, Paul A. "How I treat recurrent deep-vein thrombosis." Blood 127, no. 6 (February 11, 2016): 696–702. http://dx.doi.org/10.1182/blood-2015-09-671297.

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Abstract Deep-vein thrombosis (DVT) is regarded a chronic disease as it often recurs. DVT affects most frequently the lower limbs and hence DVT of the leg will be the focus of this article. Whereas algorithms were developed and validated for the diagnosis of a first DVT, no such well-defined strategies exist in the case of recurrence of DVT. Likewise, the scientific evidence regarding the treatment of recurrent DVT is sparse, in particular when it comes to deciding on the duration of anticoagulation. Two typical cases of recurrent DVT, one with an unprovoked DVT and one with DVT during anticoagulation, will be presented. Based on these two clinical scenarios, algorithms for the diagnosis and treatment of recurrent DVT will be put forward. The purpose of this article is to discuss strategies that can be applied in daily clinical practice by physicians who do not have access to means and measures available in specialized thrombosis centers.
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Dissertations / Theses on the topic "Deep vein thrombosis (DVT)"

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Brock, Sheila Anne. "Compression and Doppler ultrasound of deep vein thrombosis in patients on tuberculosis treatment." Thesis, Cape Peninsula University of Technology, 2013. http://hdl.handle.net/20.500.11838/1570.

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Thesis submitted in fulfilment of the requirements for the degree of Doctor of Technology: Radiography in the Faculty of Health and Wellness Sciences at the Cape Peninsula University of Technology 2013
Background. Ultrasound has until recently been regarded as a sophisticated examination reserved for tertiary health care. In reality it is well suited to the district or primary health-care situation. A DVT (deep vein thrombosis) is an important complication of the treatment of TB and this can lead to more devastating sequelae such as a pulmonary embolus. Many DVTs are clinically silent, making the diagnosis difficult. Method. This study was a prospective, longitudinal observational study. The study documented the incidence of DVTs and their onset, assessed certain aspects in an attempt to identify some risk factors, and noted the most common position of the DVT in a TB population. The feasibility of a sonographer-led ultrasound clinic for the diagnosis of DVTs was also assessed. This was achieved by screening the in-patient population at a district TB hospital. The participants received up to four routine duplex Doppler compression ultrasound examinations of the venous system of the lower extremities on week 0, week 4, week 8 and week 14. In addition a single abdominal ultrasound was performed at week 0. Results The incidence of DVTs in this TB population was 15.3%. A median of day 10 from commencing TB treatment was identified as the most common day to develop a DVT. The popliteal vein was the most frequent position for a DVT. Several statistically significant factors were identified, including a decreased ambulatory status, TB regimen and the use of anticoagulants. Only 52% of the DVTs were clinically symptomatic. The clinical evaluation for a DVT diagnosis in this study population had a sensitivity of 52.4% and a specificity of 65.3%. The positive predictive value (PPV) was 21.7%. Of the abdominal ultrasound reports there were 75.5% (281) abnormal reports, 22.5% (n = 90) normal reports and 4.5% (n = 18) with no report. Conclusion This body of work has shown how an effective ultrasound service can be provided at a district level TB hospital successfully administered by a trained ultrasonographer. This also facilitated a screening service to diagnose both symptomatic and asymptomatic deep vein thromboses in newly diagnosed tuberculosis patients. This study confirmed a higher rate of DVT in newly diagnosed TB patients than has been previously seen. It also provided detail on additional risk factors. The study illustrates the poor performance of clinical signs and symptoms as a trigger for further investigation for the confirmation of a DVT. Given the frequency and impact of the embolic complications of DVT, this study provides a strong justification for further research into routine serial ultrasonic screening and/or prophylactic antithrombolytics in newly diagnosed TB patients. As well as the DVT ultrasound scans there was the ancillary service offered by the research sonographers. This included an abdominal scan that detected abdominal pathology in 75% of the scans performed. An ultrasound scan is not pathognomonic but it does provide significant insight into the extent of some of the abdominal pathologies seen in TB patients. The information provided from this study gives a good indication of the problem that DVTs present in this population and the complexities of the disease TB. It is hoped that the results from this study will better equip the medical team in the non-tertiary situation to be vigilant for the presence of a DVT and educate them on the usefulness of the ultrasound scan.
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Autar, A. Ricky. "Advancing clinical practice in the management of deep vein thrombosis (DVT) : development, application and evaluation of the Autar DVT risk assessment scale." Thesis, De Montfort University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250780.

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Blecher, Gabriel E. "Diagnosing DVT in the Emergency Department: Combining Clinical Predictors, D-dimer and Bedside Ultrasound." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24003.

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I assessed the accuracy of two clinical prediction rules, the d-dimer blood test and point of care ultrasound for diagnosing lower limb deep vein thrombosis. Emergency physicians were trained in ultrasound and prospectively scanned emergency department patients with suspected deep vein thrombosis. Accuracy of the Wells and AMUSE rules and the ultrasound result was compared to radiology-performed ultrasound and a 90-day clinical outcome. Univariate and multivariate analyses were performed assessing which factors were associated with the outcome. The sensitivity and specificity of the Wells score for the clinical outcome was 85.7% and 68.5%; the AMUSE score 85.7% and 54.4%. Ultrasound had a sensitivity of 91.7% and specificity of 91.7% for radiology-diagnosed thrombus and 78.6% and 95.0% for clinical outcome. The odds ratio of a positive outcome with a positive ultrasound was 65.1. After receiving the ultrasound training program, emergency physicians were unable to demonstrate sufficient accuracy to replace current diagnostic strategies.
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Hebeshy, Mona Ibrahim. "ATTITUDE, SUBJECTIVE NORMS, PERCEIVED BEHAVIORAL CONTROL, AND INTENTION OF EGYPTIAN NURSES TOWARDS PREVENTION OF DEEP VEIN THROMBOSIS AMONG CRITICALLY ILL PATIENTS IN INTENSIVE CARE UNITS." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1524226281287546.

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Warwick, David John. "Deep vein thrombosis after total hip replacement." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283969.

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Howard, Adam Quentin. "The prevention of post-operative deep vein thrombosis." Thesis, Imperial College London, 2007. http://hdl.handle.net/10044/1/8187.

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Background: In a university hospital, disparate and unsatisfactory thromboprophylaxis in surgical patients was found. No hospital consensus was in place for the prevention of postoperative deep vein thrombosis (DVT). Literature review suggested low molecular weight heparin (LMWH) and anti-embolic stockings were the best prophylaxis, however the optimal length of stocking was unknown. Method: Audit of thromboprophylaxis in surgical patients and surgical doctors was performed. A randomised controlled trial investigated the efficacy and safety of a new single protocol of LMWH and the best length of stocking, for every patient requiring surgery under general anaesthesia. Of 426 patients interviewed, 376 were randomised into three stocking groups, Medi Thrombexin® Climax™ thigh-length, Thrombexin® Climax™ knee-length and Kendall TEDTM thigh-length. All patients received LMWH. DVT incidence was assessed by duplex ultrasonography. Complications of thromboprophylaxis were recorded. Compliance and health outcome measures were developed to assess patient stocking acceptability. Results: Audit revealed inadequate surgical thromboprophylaxis. A simple 'single protocol' improved doctors' thromboprophylaxis compliance on replicate audit. The randomised trial assessing the 'single protocol' showed no postoperative DVT occurred in the low or moderate-risk patients (n=85). Twenty-one DVT occurred in nineteen patients, all were high-risk patients (n=291): two with Thrombexin® Climax™ thigh-length stockings and eleven with Thrombexin® Climax™ kneelength (p
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Baarslag, Hendrik Jan. "Diagnosis and management of upper extremity deep vein thrombosis." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/86567.

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Cate-Hoek, Arina Janna ten. "New developments in diagnosis and treatment of deep vein thrombosis." [Maastricht] : Maastricht : [Maastricht University] ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=13095.

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Kahn, Susan Rebecca. "Clinical predictors of deep vein thrombosis in patients with leg symptoms." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27355.

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Background. Deep vein thrombosis (DVT) is a common condition with significant mortality and morbidity. Proximal DVT is more often associated with pulmonary embolism and the post-phlebitic syndrome than calf DVT. Identifying which clinical variables predict DVT and proximal DVT could be useful for the effective targeting of diagnostic tests for DVT.
Purpose. To determine, in patients presenting with leg symptoms, which clinical variables best predict (1) DVT and (2) proximal DVT. To estimate the probability of DVT in an individual presenting with a particular grouping of these variables.
Results. Male sex, orthopedic surgery, and warmth and superficial venous dilation on exam were independent predictors of DVT (adjusted odds ratios and 95% confidence intervals 2.8 (1.5, 5.1), 5.4 (2.2, 13.6), 2.1 (1.2, 3.9) and 2.9 (1.4, 5.7), respectively) and proximal DVT (adjusted odds ratios 2.4 (1.2, 4.8), 4.1 (1.4, 12.3), 2.3 (1.2, 4.7) and 3.4 (1.6, 7.0), respectively). A clinical prediction index that categorized patients into different levels of DVT risk was created, and its ROC curve showed moderate predictive ability. No single cutoff point was ideal in terms of desired sensitivity and specificity, however the index was useful in a strategy aimed to limit the need for contrast venography in patients with suspected DVT. Using this strategy, 78% of study patients could have avoided contrast venography. (Abstract shortened by UMI.)
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Kahn, Susan Rebecca. "Clinical predictors of-deep vein thrombosis in patients with leg symptoms." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29730.pdf.

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Books on the topic "Deep vein thrombosis (DVT)"

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Autar, Atmaram. Nursing assessment of clients at risk of deep vein thrombosis (DVT): Developing the Autar DVT scale. Birmingham: University of Central England in Birmingham, 1994.

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Autar, A. R. Advancing clinical practice in the management of Deep Vein Thrombosis (DVT): Development, application and evaluation of the Autar DVT risk assessment scale. Leicester: De Montfort University, 2002.

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Autar, Ricky. Deep vein thrombosis: The silent killer. Wilts: Quay Books, 1996.

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Griffin, Jane. Deep vein thrombosis and pulmonary embolism. London: Office of Health Economics, 1996.

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van Beek, Edwin J. R., Harry R. Bller, and Matthijs Oudkerk, eds. Deep Vein Thrombosis and Pulmonary Embolism. Chichester, UK: John Wiley & Sons, Ltd, 2009. http://dx.doi.org/10.1002/9780470745007.

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Raskin, Gregory Stephen. Bedside doppler identification of lower-extremity deep-vein thrombosis. [New Haven, Conn: s.n.], 1998.

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F, Tapson Victor, and Ortel Thomas L. 1957-, eds. 100 questions & answers about deep vein thrombosis and pulmonary embolism. Sudbury, Mass: Jones and Bartlett Publishers, 2008.

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Inc, ebrary, ed. Deep vein thrombosis and pulmonary embolism: A guide for practitioners. Cumbria [England]: M&K Update Ltd., 2009.

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Parker, James N., and Philip M. Parker. Deep vein thrombosis: A medical dictionary, bibliography, and annotated research guide to Internet references. San Diego, CA: ICON Health Publications, 2004.

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Tinkler, Kerry. Setting up, piloting, implementing and reviewing a GP direct access service for the diagnosis of lower limb deep vein thrombosis. Portsmouth: University of Portsmouth, 2004.

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Book chapters on the topic "Deep vein thrombosis (DVT)"

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Bashal, Fozya. "Thrombosis in Rheumatological Diseases." In Skills in Rheumatology, 263–89. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-8323-0_12.

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AbstractVenous thromboembolism (VTE) is a disease of blood coagulation that occurs in the veins, most often in the calf veins first, from where it may extend and cause deep vein thrombosis (DVT) or pulmonary embolism (PE). The first described case of venous thrombosis that we know of dates back to the thirteenth century, when deep vein thrombosis was reported in the right leg of a 20-year-old man [1].
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Cushner, Gilbert B., Fred D. Cushner, and Michael A. Cushner. "Deep Vein Thrombosis (DVT) and Total Knee Arthroplasty." In Surgical Techniques in Total Knee Arthroplasty, 694–704. New York, NY: Springer New York, 2002. http://dx.doi.org/10.1007/0-387-21714-2_92.

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Samama, Michel-Meyer. "Treatment of Deep Vein Thrombosis (DVT) with Low Molecular Weight Heparins (LMWH)." In Advances in Experimental Medicine and Biology, 275–81. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4899-2444-5_27.

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Zakaria, W. N. Wan, N. Ibrahim, N. Mat Harun, Razali Tomari, and M. K. Abdullah. "Study of Vessel Conditions for Deep Vein Thrombosis (DVT) Diagnosis According to Body Mass Index." In IFMBE Proceedings, 447–49. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11776-8_110.

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Ibrahim, N., W. N. Wan Zakaria, N. Aziz, and M. K. Abdullah. "Construction of Phantom Mimic Vessel for Study of Human Vessel Conditions in Deep Vein Thrombosis (DVT)." In IFMBE Proceedings, 402–4. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11776-8_98.

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Desai, Sapan S., Eric Mowatt-Larssen, and Ali Azizzadeh. "Deep Vein Thrombosis." In Phlebology, Vein Surgery and Ultrasonography, 281–92. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01812-6_20.

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Bauersachs, Rupert M., and Bernd Krabbe. "Deep Vein Thrombosis." In PanVascular Medicine, 4455–81. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-37078-6_208.

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Bauersachs, Rupert M., and Bernd Krabbe. "Deep Vein Thrombosis." In PanVascular Medicine, 1–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-37393-0_208-1.

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Coccheri, Sergio. "Deep vein thrombosis." In Developments in Cardiovascular Medicine, 403–17. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-011-5406-2_28.

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Masterton-Smith, Charlotte, and Kevin O'Kane. "Deep vein thrombosis." In Acute Medicine - A Practical Guide to the Management of Medical Emergencies, 5th Edition, 353–57. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119389613.ch56.

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Conference papers on the topic "Deep vein thrombosis (DVT)"

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Widmer, L. K., M. Th Widmer, E. Zemp, F. Duckert, G. Marbet, H. E. Schmitt, E. Brandenberg, and R. Voëlin. "LONG-TERM MORBIDITY AFTER DEEP VEIN THROMBOSIS (DVT)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642969.

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5 yr follow-up of 341 patients with special consideration of post-thrombotic syndrome (PTS) and methodolo-cigal difficulties.INTRODUCTIONMethodological difficulties responsable for lacking unité de doctrine: (a) Acute phase: random allocation taking into account DVT of different extent; assessment of effect of treatment (b) Follow-up: drop out definition of parameters of success esp. PTS, comparison of truely comparable groups, limited information about economic aspects.5 yr FOLLOW-UP PTS-INCIDENCE after ANTICOAGULATION (AC) or THROMBOLYSIS (TL)Method: 341 non-randomized, consecutive patients; unilateral DVT documented by initial and control-phlebo-gramm (<14 d) , treated by AC or thrombolytic agents. 226 men, 115 women, 51.9 ± 16 yr at entry. DVT: left 193, right 148; limited 35 %, extended 65 %. Treatment effect by analysis “vein per vein”. Re-examination: “blind technique” by 2 observers; definition of PTS considering corona phlebectatica, cyanosis, edema, cirumference difference, trophic changes; Score > 10= PTSResults:1. Group with unchanged initial and control phlebogrammCorrelation between DVT-extent at entry and PTS-incidence (table). Consequently comparison of AC and TL must be made between subgroups with similar DVT-extent at entry.2. Subgroups with clearance ( + ) vs. non-clearance ( - ):Figures white PTS without ulcera, black leg ulcer
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Prandoni, P., A. W. A. Lensing, G. Zambon, A. Breda, S. Cuppini, and J. W. ten Cate. "ACQUIRED RISK FACTORS AND DEEP VEIN THROMBOSIS IN SYMPTOMATIC OUT PATIENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643110.

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Previous studies revealed a number of acquired risk factors predisposing to acute deep vein-thrombosis (DVT). Unfortunately many of these clinical or epidemiologic studies were not proper designed, since they didn't include consecutive patients, used no or different types of objective endpoints or collected the data retrospectively. In a prospective trial we evaluated 307 consecutive out-patients with clinically suspected DVT by using ascending venography, which confirmed suspicion in 136 (44%). A history of prior thrombotic episodes as well as factors predisposing to DVT including advancing age, obesity, smoking habits, cancer, chronic lung and/or heart disease, immobilization, pregnancy, childbirth, chronic liver disease, systemic lupus erythematosus (SLE), nephrotic syndrome, varicose veins, fractures or trauma or chronic arteriopathies of the legs, diabetes mellitus (DM), recent surgery and estrogen therapy were recorded in all patients. The results of our comparison of these risk factors with the outcome of venography indicate clearly a significant difference (chi-square test) between patients with and without DVT for the following: -previous documented thromboembolism, cancer (p < 0.01); -chronic lung and/or heart disease, age > 65 years, immobilization (p < 0.05). The frequency of pregnancy, childbirth, nephrotic syndrome and chronic liver disease among our patients was too low for providing sufficiently narrow confidence limits. Surprisingly the presence of varicose veins will decrease the possibility of DVT (p < 0.01). In all patients (n=3) affected by SLE clinical suspicion was confirmed. Obesity, smoking habits, recent trauma or fracture or chronic artheriopathies of the legs, DM, recent surgery and estrogen therapy were not associated with an increased risk of thrombosis, since their presence in both groups was approximately the same.
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3

Mellbring, G., J. Chotai, and T. K. Nilsson. "PLASMA DEHYDROEPIANDROSTERONE SULPHATE CONCENTRATIONS AND DEEP VEIN THROMBOSIS AFTER MAJOR ABDOMINAL SURGERY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644208.

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Dehydroepiandrosterone sulphate (DHEAS) is a major secretory product of the human adrenal gland. Its precise functions are uncertain, but it has been postulated as a discriminator of life expectancy and aging. We have previously reported significantly lower plasma levels of DHEAS pre- and postoperatively in men developing DVT after major abdominal surgery, as compared to patients who remained free of DVT. Recent data suggest that the DHEAS concentration is also independently and inversely related to death from cardiovascular disease in men over 50 years of age. We here report data on preoperative plasma concentrations of DHEAS (measured with RIA) in 96 patients over 40 years of age, who underwent major abdominal surgery, and correlated the result to the development of postoperative DVT as diagnosed by the 125I-fibrinogen uptake test.Thirty patients (31%) developed postoperative DVT during the first ten postoperative days. The plasma levels of DHEAS were significantly lower in the patients with postoperative DVT compared to those without (median 1.95 umol/1; Q1−Q3, 1.30−3.00 vs. median 3.35 umol/1; Q1−Q3 1.60−4.70; p < 0.02). Ninety per cent of the patients who developed postoperative DVT had a DHEAS value lower than 3.9 umol/1, while 45 % of the patients who remained free of DVT had a DHEAS value higher than 3.9 umol/1.In conclusion, the data suggest that a low preoperative value of DHEAS predisposes the development of postoperative DVT in patients undergoing major abdominal surgery. It seems like the DHEAS concentration in plasma can be a valuable factor in a predictive index for postoperative DVT in those patients.
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Stewart, G. J., J. W. Lachman, P. D. Alburger, M. C. Ziskin, C. M. Philips, and K. Jensen. "VENODILATION AND DEVELOPMENT OF DEEP VEIN THROMBOSIS IN TOTAL HIP AND KNEE REPLACEMENT PATIENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643696.

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Postoperative deep vein thromboisis(DVT) is a frequent complication following total hip (THR) or knee (TKR)replacement but no test has been devised to identify specific patientswho will develop DVT. Because conventional prophylaxis does not significantly reduce the incidence of DVT, monitoring is widely used to detect evolving thrombosis. More intense anticoagulation (adjusted dose heparin,two step warfarin) may be effective but requires laboratory tests and carries increased risk of bleeding. Itwould be an economic and medical advantage to restrict prophylaxis and monitoring to patients who will develop DVT. Based on observations in a canine model of THR, we developed andtested a method that shows promise of being able toidentify, intraoperatively, patients who will develop DVT.In the canine model we found characteristic venous lesions (gaping tears through endothelium and basementmembrane, localized to confluences,selectively infiltrated with platelets and leukocytes). Incidence of lesions correlated with intraoperative venodilation, measured by a modified ultrasound scanner. Lesionsmight serve as sites for initiationand anchorage of thrombi. Diagnostic ultrasound was used to monitor cephalic vein diameter in 25 THR patients and 12 TKR patients. In THR patients, 1 of 9 patients with venodilation of 6-16% developed DVT. At 21-57% venodilation 12 of 12 THR patients developed thrombi. In the intermediate range of venodilation (19%,20%), 2 of 4 patients developedDVT. In 12 TKR patients, 10 had venodilation of 0-16% and none developedDVT in the non-operated leg. In patients with 22% and 55% venodilation,one did and one did not develop DVT in the non-operated leg (expectedfrcxn equal distribution between legs in THR patients).DVT in the operated leg did not correlate with venodilation. We suggest that in THR patients substances released at the operative site circulate briefly, causing venous dilation. In TKR patients the tourniquet prevented substances from being circulated, reducing venodilation and DVT in the non-operated leg. Proximitv of surgicalwound to calf veins and tourniquet pressure mav have contributed to DVT in the operated leg.
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Elias, A., G. Le Corff, J. L. Bouvier, Ph Villain, and A. Serradimigni. "DISCREPANCIES BETWEEN VENOGRAPHY AND REAL TIME B MODE ULTRASOUND IMAGING IN THE DIAGNOSIS OF DEEP VEIN THROMBOSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642892.

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Methods : in this prospective study, real time B Mode ultrasound imaging (USI) was compared to bilateral ascending contrast venography, double blindly, in 430 patients suspected of deep vein thrombosis (DVT) or pulmonary embolism.A complete scan of the venous system from the inferior vena cava to the calf veins, was performed with a high resolution duplex system (DIASONICS DRF 400) and coupled systematically with a C.W. Doppler examination. The results obtained by USI were thus compared to the venograms performed on a total of 854 legs.Results : there are corresponding results in 95% of the legs (808/854). If we consider venography as the standard of reference, the sensitivity of USI is 98% (325/333) and the specificity 94% (483/514). Isolated calf vein thrombosis are detected in 91% (84/92) of the legs and proximal DVT in 100% (241/241) in this series whatever the topography and the extension of the thrombosis and whatever the degree of the obstruction of the vein.Discrepancies found in 46 legs are related to :- 8 DVT located in the calf (6 in the presumed healthy leg) diagnosed only by venography.- 27 DVT (18 distal, 9 femoral or iliac) detected only by USI- 9 doubtful examinations with USI not confirmed by venography- 2 doubtful venograms with negative USI test.Comments : Calf vein thrombosis especially located in the soleal sinuses and the gastrocnemius with in most cases the direct image of the thrombus are more often detected by USI provided that the technique and the equipment are appropriate.The absence of visualisation of venous segments with venography is not specific of venous thrombosis. These veins non affected by the thrombosis are not filled by the contrast medium when located above in occluded ilio-femoral or ilio-caval junction or when they are the site of extrinsic compression. The direct image of the vein and the surrounding structures obtained with USI enhances the diagnostic sensitivity and specificity and provides precision of the exact extension of the thrombosis.Due to these differences, can venography still be considered as the standard of reference in the diagnosis of DVT and their precise localisation ?
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Soria, C., Mc Mirshahi, J. Soria, M. Mirshahi, R. Faivre, D. Neuhart, Y. Kieffer, J. P. Maurat, and J. P. Caen. "MONITORING OF DEEP VEIN THROMBOSIS BY D DIMER DETERMINATION. INFLUENCE OF HEPARIN REGIMEN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643134.

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In 49 patients the level of plasma fibrin degradation products (FbDP) was measured during the first ten days of deep vein thrombosis (DVT) in order to determine whether FbDP may be used as a non invasive marker to follow the evolution of DVT. Plasma FbDP was measured precisely and reliably by Elisa using a personal anti D neo monoclonal antibody. Thrombus size was determined angiographically on day 0 and day 10 and expressed according to Marder score. Patients were treated by standard or by a very low molecular weight heparin (CY 222 from Choay Laboratory, Paris France).It is shown that before treatment, in 45 cases of DVT the level of FbDP was dramatically increased as compared to control and remained normal or slightly elevated in 4 cases of DVT. The correlation between thrombus size and FbDP level at day 0 was poor (p = 0.3). During the 10 days of treatment, FbDP determination may give some informations about the evolution of DVT. Three groups were defined :1 There was no reduction of thrombus size in patients who presented a normal or only slightly elevated FbDP level, leading to the evidence that thrombolysis was almost inexistant in these patients.2 Thrombolysis was almost complete in 10 days in patients presented both a high FbDP level before treatment and a dramatic decrease of FbDP after 10 days treatment. Taking into account the half life of FbDP, the decrease in FbDP level is related to the reduction in thrombus size.3 A partial or absence of recanalization was evidenced in patients presenting a high FbDP level throughout the 10 days on therapy. In cases without recanalization we have to assume that thrombolysis evidenced by plasma FbDP level was continuously counteract by a clotting process.Similar results were observed in patient treated by standard and CY 222.
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7

Eriksson, B., E. Eriksson, E. Gyzander, A. C. Teger-Nilsson, and B. Riseberg. "TOTAL HIP REPLACEMENT AND DEEP VEIN THROMBOSIS - RELATIONSHIP TO THE FIBRINOLYTIC SYSTEM." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643694.

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Reduced fibrinolytic activity increases the risk of recurrent thromboembolism and it has been suggested thatit also plays a role in postoperative thrombosis.Material and methods. Fibrinolytic parameters were analysed in 29 patients submitted to total hip replacement. Dextran 70 was given as thrombosis prophylaxis. Blood samples weretaken pre operatively, one day and oneweek postoperatively. Venous occlusion test was done in all patients.125 I-fibrinogen test was used for deep vein thrombosis (DVT) screening.Positive test was confirmed with phlebography. Fibrinolytic activity was measured on fibrin plates. Tissueplasminogen activator (t-PA) and itsspecific inhibitor (PAI) were analysed with photometric and immunologicalmethods.Results. The first postoperative dayt-PA activity decreased and PAI increased significantly. One week after operation only PAI showed significatdifference from preoperative values.10 of the patients developed DVT.The PAI level significantly higher in DVT patients preoperatively. Thisdifference in PAI level was significant compared with non-DVT patients also one day and one week postoperatively.Conclusion. The recently discovered t-PA inhibitor (PAI) seems to be correlated to postoperative thrombosis in total hip surgery.
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8

Prandoni, P., M. Vigo, M. V. Huisman, J. Jonker, H. R. Büller, and J. W. ten Cate. "COMPUTERIZED IMPEDANCE PLETHYSMOGRAPHY, A NEW PLETHYSMOGRAPHIC METHOD TO DETECT DEEP VEIN THROMBOSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642893.

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Since the clinical diagnosis of deep vein thrombosis (DVT) is unreliable, several invasive and non-invasive methods have been developed recently. Of these, impedance plethysmography (IPG) is a widely employed technique based on measurement of changes in blood volume produced by temporary obstruction. IPG has been shovn in large prospective studies in symptomatic patients to be a safe and effective alternative to contrast venography, if used either in combination with 1251-fibrinogen legscanning or serially as a single test. Currently available impedance plethysmographs are limited by several technical and operational problems. Therefore, a new computerized impedance plethysmograph (CIP) was developed, having the following characteristics: portability, battery operated and fully automated. A prospective two-center study in 299 consecutive outpatients was done to compare the efficacy of CIP vs. venography in patients with symptomatic DVT. Using a blind design i.e. care was taken to insure that CIP and venography were performed and interpreted independently. The results in patients without venography proven thrombosis and those with proximal vein thrombosis were subjected to a discriminant analysis producing a line of best discrimination between normal and proximal vein thrombosis. In 14 patients it was not possible to obtain an adequate CIP tracing. 12 patients were not entered because of refusal to undergo venography and 15 patients were excluded from analysis because of poor opacification of the proximal veins. On the basis of discriminant analysis 138 of the CIP results were classified as normal and 120 as abnormal. 175 patients were normal on venography and 83 had proximal thrombosis. The sensitivity of CIP for proximal vein thrombosis was thus 95% while the speci-+ ficity was 77%. It is concluded that computerized impedance plethysmography is a potentially sensitive method to detect proximal vein thrombosis in patients with clinically suspected deep vein thrombosis.
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Zahavi, J., S. Zaltzman, E. Firsteter, and E. Avrahami. "SEMI-QUANTITATIVE RADIONUCLIDE PHLEBOGRAPHIC (RNP) ASSESSMENT OF DEEP VEIN THROMBOSIS (DVT) AND CHRONIC VENOUS INSUFFICIENCY (CVI)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642895.

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A semi-quantitative RNP using 99Technetium macroaggregated albumin for the evaluation and follow-up of DVT and CVI has been developed. Values were assigned to the deep veins of the calf, knee, tigh and pelvis based upon the localization and the characteristics of the images obtained: stasis, hot spots and collateral circulation. A maximum score of 18 reflected complete thrombosis of all 4 segments. 208 patients (mean age 53.7 years, range 18-92), 161 of whom had a proven risk factor for DVT were studied. 99Technetium was injected into the dorsal foot vein of 407 limbs with appropriate tourniquets and early and late imaging of the limbs, pelvis and lungs was performed. In 48 patients, 83 limbs, X-ray contrast phlebography (CP) was also done. The mean RNP score was 4.1 units (range 0.4-18) and higher in the left than the right lower limb. It was mostly high in patients with proximal recurrent DVT or in DVT superimposed on CVI. The score was easy to follow and helpful in the assessment of the extent of DVT. It was particularly helpful in 3 instances. 1) Assessment of venous patency following anticoagulant therapy. 2) Estimation of recurrent DVT. 3) Differentiation of recent DVT from venous insufficiency. Overall RNP method had a sensitivity of 87.6%, a specificity of 54% and an accuracy of 64.8%. The sensitivity was similar in above & below-knee thrombi. Yet the specificity was higher in above-knee thrombi. The highest accuracy (87.3%) was observed in pelvic and groin thrombi. The distribution of thrombi on CP was 19% below the knee, 31% above it and 50% both above and below the knee. Pulmonary embolism (PE) was initially observed in 54 patients (26%) with no clinical evidence of DVT and therefore untreated. This high level is most probably related to the high incidence of proximal DVT in the patients. 181 patients were treated with heparin & coumadin and the RNP score was decreased to 3.6 units (range 0.4-8.8). PE occurred during treatment in 11 (6.1%) and recurrent DVT in 16 (8.8%) patients. CVI was observed in 23 patients before treatment and in another 24 patients (13.2%) after treatment. These results indicate that the RNP method is a simple, semi-quantitative and useful technique for the evaluation and follow-up of DVT and CVI. It is most helpful in the assessment of the extent of DVT. It is also a rapid, noninvasive and cost effective techniaue.
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10

Zawilska, K., A. Tokarz, P. Psuja, P. Szymczak, S. Kawczyński, M. Zozulińska, Z. Turowiecka, and J. Sowier. "ANABOLIC STEROID AND INTRAPULMONARY HEPARIN IN THE PREVENTION OF POSTOPERATIVE DEEP VEIN THROMBOSIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644207.

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150 patients over 40 years old undergoing major abdominal surgery were divided into 3 groups:1/ group I - receiving a single injection of long acting anabolic steroid /nandrolone phenylpropio-nate, 50 mg intramusculary/ a day prior to surgery 2/ gropup II - receiving the same dose of anabolic steroid plus a single dose of heparin /800 U/kg of body weight/ intrapulmonary a day prior to surgery 3/ group III - receiving only a single dose of heparin /800 U/kg of body weight/ intrapulmonary a day prior to surgery.The deep vein thrombosis /DVT/ was detected using the 125 I-fibrinogen test. The occurence of DVT was:in group I - 14%in group II - 4%in group III - 8%There were no detectable haemorrhagic complications in patients of group I and III, in 6% of patients of group II a sgliht increase of intraoperative bleeding and/or wound hematoma appeared.We conclude that prophylaxis of DVT in the postoperative period with the single dose of anabolic steroid and intrapulmonary heparin is an effective, safe and easy to handle procedure.
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Reports on the topic "Deep vein thrombosis (DVT)"

1

Saldanha, Ian J., Wangnan Cao, Justin M. Broyles, Gaelen P. Adam, Monika Reddy Bhuma, Shivani Mehta, Laura S. Dominici, Andrea L. Pusic, and Ethan M. Balk. Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis. Agency for Healthcare Research and Quality (AHRQ), July 2021. http://dx.doi.org/10.23970/ahrqepccer245.

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Objectives. This systematic review evaluates breast reconstruction options for women after mastectomy for breast cancer (or breast cancer prophylaxis). We addressed six Key Questions (KQs): (1) implant-based reconstruction (IBR) versus autologous reconstruction (AR), (2) timing of IBR and AR in relation to chemotherapy and radiation therapy, (3) comparisons of implant materials, (4) comparisons of anatomic planes for IBR, (5) use versus nonuse of human acellular dermal matrices (ADMs) during IBR, and (6) comparisons of AR flap types. Data sources and review methods. We searched Medline®, Embase®, Cochrane CENTRAL, CINAHL®, and ClinicalTrials.gov from inception to March 23, 2021, to identify comparative and single group studies. We extracted study data into the Systematic Review Data Repository Plus (SRDR+). We assessed the risk of bias and evaluated the strength of evidence (SoE) using standard methods. The protocol was registered in PROSPERO (registration number CRD42020193183). Results. We found 8 randomized controlled trials, 83 nonrandomized comparative studies, and 69 single group studies. Risk of bias was moderate to high for most studies. KQ1: Compared with IBR, AR is probably associated with clinically better patient satisfaction with breasts and sexual well-being but comparable general quality of life and psychosocial well-being (moderate SoE, all outcomes). AR probably poses a greater risk of deep vein thrombosis or pulmonary embolism (moderate SoE), but IBR probably poses a greater risk of reconstructive failure in the long term (1.5 to 4 years) (moderate SoE) and may pose a greater risk of breast seroma (low SoE). KQ 2: Conducting IBR either before or after radiation therapy may result in comparable physical well-being, psychosocial well-being, sexual well-being, and patient satisfaction with breasts (all low SoE), and probably results in comparable risks of implant failure/loss or need for explant surgery (moderate SoE). We found no evidence addressing timing of IBR or AR in relation to chemotherapy or timing of AR in relation to radiation therapy. KQ 3: Silicone and saline implants may result in clinically comparable patient satisfaction with breasts (low SoE). There is insufficient evidence regarding double lumen implants. KQ 4: Whether the implant is placed in the prepectoral or total submuscular plane may not be associated with risk of infections that are not explicitly implant related (low SoE). There is insufficient evidence addressing the comparisons between prepectoral and partial submuscular and between partial and total submuscular planes. KQ 5: The evidence is inconsistent regarding whether human ADM use during IBR impacts physical well-being, psychosocial well-being, or satisfaction with breasts. However, ADM use probably increases the risk of implant failure/loss or need for explant surgery (moderate SoE) and may increase the risk of infections not explicitly implant related (low SoE). Whether or not ADM is used probably is associated with comparable risks of seroma and unplanned repeat surgeries for revision (moderate SoE for both), and possibly necrosis (low SoE). KQ 6: AR with either transverse rectus abdominis (TRAM) or deep inferior epigastric perforator (DIEP) flaps may result in comparable patient satisfaction with breasts (low SoE), but TRAM flaps probably increase the risk of harms to the area of flap harvest (moderate SoE). AR with either DIEP or latissimus dorsi flaps may result in comparable patient satisfaction with breasts (low SoE), but there is insufficient evidence regarding thromboembolic events and no evidence regarding other surgical complications. Conclusion. Evidence regarding surgical breast reconstruction options is largely insufficient or of only low or moderate SoE. New high-quality research is needed, especially for timing of IBR and AR in relation to chemotherapy and radiation therapy, for comparisons of implant materials, and for comparisons of anatomic planes of implant placement.
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2

Thrombolysis may reduce complications of deep vein thrombosis. National Institute for Health Research, April 2017. http://dx.doi.org/10.3310/signal-000409.

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3

New drugs for deep vein thrombosis may offer a safe alternative to warfarin. National Institute for Health Research, October 2015. http://dx.doi.org/10.3310/signal-000137.

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