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Journal articles on the topic 'Defeat of the musculoskeletal system'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Fedotova, A. S., N. N. Molitvoslovova, L. I. Alekseeva, et al. "CONDITION OF THE MUSCULOSKELETAL SYSTEM IN PATIENTSWITH ACROMEGALY." Osteoporosis and Bone Diseases 13, no. 1 (2010): 19–27. http://dx.doi.org/10.14341/osteo2010119-27.

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Despite the relatively low incidence of acromegaly (60-70 cases per I million inhabitants), this disease has a special place among the heterogeneous group of diseases that lead to the defeat of the locomotor apparatus. The slow growth of the clinical manifestations of acromegaly and as a consequence, late diagnosis, the cause of early disability and premature death of patients. In order to improve the quality of life and social adaptation of patients to date is an obvious need to identify groups of patients with acromegaly, requiring additional therapy for osteoporosis and osteoarthritis. We p

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Minoranskaya, N. S., and E. I. Minoranskaya. "CLINICAL AND PATHOGENETIC CHARACTERISTICS OF CHRONIC IXODES TICK-BORNE BORRELIOSIS WITH THE DEFEAT OF MUSCULOSKELETAL SYSTEM." Siberian Medical Review, no. 2 (2014): 62–67. http://dx.doi.org/10.20333/25000136-2014-2-62-67.

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3

Chan, C. C.-H., and G. A. Munroe. "Congenital defects of the equine musculoskeletal system." Equine Veterinary Education 8, no. 3 (1996): 157–63. http://dx.doi.org/10.1111/j.2042-3292.1996.tb01677.x.

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4

Skvortsov, A. P. "Surgical treatment of knee joint deformities after hematogenous osteomyelitis." Kazan medical journal 82, no. 2 (2001): 152–55. http://dx.doi.org/10.17816/kazmj70219.

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Hematogenous osteomyelitis is still a common disease, accounting for 6-10% of all pyoinflammatory diseases [3], while the incidence varies from 0.3 to 0.75 per 1000 child population. The proportion of complications of acute hematogenous osteomyelitis (CSO) in the structure of purulent-septic diseases ranges from 8.6 to 12%, in the structure of orthopedic pathology - from 3 to 6% [4]. Orthopedic complications (dislocations, deformities, shortening, contractures and ankylosis of large joints) are observed in 3171% of cases [5]. In children, the severity of the disease in the long term is aggrava

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5

Panevin, Taras S., Lyudmila I. Alekseeva, Elena A. Taskina, and Natalia G. Kashevarova. "Limited joint mobility syndrome as a predictor of the diabetic foot syndrome." Osteoporosis and Bone Diseases 22, no. 3 (2020): 19–26. http://dx.doi.org/10.14341/osteo12280.

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Diabetes mellitus (DM) can lead to the development of late complications. In addition to the traditional late complications, a high prevalence of damage to the musculoskeletal system in diabetes was noted. The most appropriate term that reflects the defeat of the musculoskeletal system in diabetes is limited joints mobility syndrome (LJM). Damage to the hands in the presence of open painless stiffness of the joints, fixed flexion contractures, impaired fine motor skills of the hands and grip forces. Subsequently, it became clear that, over time, the restriction of joint mobility develops not o

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6

Aparisi Gómez, Maria Pilar, Sheryl Watkin, David Perry, Paolo Simoni, Giovanni Trisolino, and Alberto Bazzocchi. "Anatomical Considerations of Embryology and Development of the Musculoskeletal System: Basic Notions for Musculoskeletal Radiologists." Seminars in Musculoskeletal Radiology 25, no. 01 (2021): 003–21. http://dx.doi.org/10.1055/s-0041-1723005.

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AbstractThe musculoskeletal (MSK) system begins to form in the third week of intrauterine development. Multiple genes are involved in the complex different processes to form the skeleton, muscles and joints. The embryonic period, from the third to the eighth week of development, is critical for normal development and therefore the time when most structural defects are induced. Many of these defects have a genetic origin, but environmental factors may also play a very important role. This review summarizes the embryology of the different components of the MSK system and their configuration as a

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7

Johnson, Aaron N. "Myotube Guidance: Shaping up the Musculoskeletal System." Journal of Developmental Biology 12, no. 3 (2024): 25. http://dx.doi.org/10.3390/jdb12030025.

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Myofibers are highly specialized contractile cells of skeletal muscles, and dysregulation of myofiber morphogenesis is emerging as a contributing cause of myopathies and structural birth defects. Myotubes are the myofiber precursors and undergo a dramatic morphological transition into long bipolar myofibers that are attached to tendons on two ends. Similar to axon growth cones, myotube leading edges navigate toward target cells and form cell–cell connections. The process of myotube guidance connects myotubes with the correct tendons, orients myofiber morphology with the overall body plan, and

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8

Sun, Tianze, Jinzuo Wang, Moran Suo, et al. "The Digital Twin: A Potential Solution for the Personalized Diagnosis and Treatment of Musculoskeletal System Diseases." Bioengineering 10, no. 6 (2023): 627. http://dx.doi.org/10.3390/bioengineering10060627.

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Due to the high prevalence and rates of disability associated with musculoskeletal system diseases, more thorough research into diagnosis, pathogenesis, and treatments is required. One of the key contributors to the emergence of diseases of the musculoskeletal system is thought to be changes in the biomechanics of the human musculoskeletal system. However, there are some defects concerning personal analysis or dynamic responses in current biomechanical research methodologies. Digital twin (DT) was initially an engineering concept that reflected the mirror image of a physical entity. With the a

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9

Piróg, Katarzyna A., and Michael D. Briggs. "Skeletal Dysplasias Associated with Mild Myopathy—A Clinical and Molecular Review." Journal of Biomedicine and Biotechnology 2010 (2010): 1–13. http://dx.doi.org/10.1155/2010/686457.

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Musculoskeletal system is a complex assembly of tissues which acts as scaffold for the body and enables locomotion. It is often overlooked that different components of this system may biomechanically interact and affect each other. Skeletal dysplasias are diseases predominantly affecting the development of the osseous skeleton. However, in some cases skeletal dysplasia patients are referred to neuromuscular clinics prior to the correct skeletal diagnosis. The muscular complications seen in these cases are usually mild and may stem directly from the muscle defect and/or from the altered interac

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10

Leipold, Horst W., Takeo Hiraga, and Stanley M. Dennis. "Congenital Defects of the Bovine Musculoskeletal System and Joints." Veterinary Clinics of North America: Food Animal Practice 9, no. 1 (1993): 93–104. http://dx.doi.org/10.1016/s0749-0720(15)30674-5.

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11

Baindurashvili, A. G., K. S. Solov’Yova, A. V. Zaletina, and Yu A. Lapkin. "Congenital Abnormalities (developmental defects) and Musculoskeletal System Deformities in Children." Vestnik travmatologii i ortopedii imeni N.N. Priorova, no. 3 (September 30, 2014): 15–20. http://dx.doi.org/10.32414/0869-8678-2014-3-15-20.

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Data of RF Health Ministry official statistics, Federal Genetic Register and Congenital Defects Monitoring Center, and St. Petersburg Diagnostic (Medical Genetic) Center were analyzed. It is stated that within XVII Class of ICD-10 “Congenital abnormalities (developmental defects), deformities and chromosomal disorders” congenital malformations (developmental defects) and musculoskeletal system (MSS) deformities make up 20 - 22% and handicapped children account for 25 - 28%. The rate of MSS abnormalities diagnosed in maternity hospitals is 4.0 - 4.4 per 1000 of newborns. Rate and structure of M

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12

Baindurashvili, A. G., K. S. Solov’yova, A. V. Zaletina, and Yu A. Lapkin. "Congenital Abnormalities (developmental defects) and Musculoskeletal System Deformities in Children." N.N. Priorov Journal of Traumatology and Orthopedics 21, no. 3 (2014): 15–20. http://dx.doi.org/10.17816/vto20140315-20.

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Data of RF Health Ministry official statistics, Federal Genetic Register and Congenital Defects Monitoring Center, and St. Petersburg Diagnostic (Medical Genetic) Center were analyzed. It is stated that within XVII Class of ICD-10 “Congenital abnormalities (developmental defects), deformities and chromosomal disorders” congenital malformations (developmental defects) and musculoskeletal system (MSS) deformities make up 20 - 22% and handicapped children account for 25 - 28%. The rate of MSS abnormalities diagnosed in maternity hospitals is 4.0 - 4.4 per 1000 of newborns. Rate and structure of M

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13

Shakya, Shristi, Kalpana Upadhaya Subedi, and Megha Mishra. "Incidence of Birth Defects among Live Born Neonates at Tertiary Level Maternity Hospital in Nepal." Journal of Nepal Paediatric Society 42, no. 2 (2022): 36–39. http://dx.doi.org/10.3126/jnps.v42i2.41093.

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Introduction: Birth defects are structural and functional anomalies that present before, at birth, or later in life. This study aimed to find out total incidence, type of structural birth defects in live born babies in Nepal. Methods: The study was conducted at a tertiary level maternity hospital in Nepal from 14 April 2018 to 13 April 2019. Data was collected on online Newborn Birth Defect data base developed by WHO South- East-Asia Regional Office. All live born babies with external and internal birth defects confirmed by radiographic, ultrasonography and echocardiography until seven days of

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Ye, Bing, Bin Wu, Yanlin Su, Tingfang Sun, and Xiaodong Guo. "Recent Advances in the Application of Natural and Synthetic Polymer-Based Scaffolds in Musculoskeletal Regeneration." Polymers 14, no. 21 (2022): 4566. http://dx.doi.org/10.3390/polym14214566.

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The musculoskeletal system plays a critical role in providing the physical scaffold and movement to the mammalian body. Musculoskeletal disorders severely affect mobility and quality of life and pose a heavy burden to society. This new field of musculoskeletal tissue engineering has great potential as an alternative approach to treating large musculoskeletal defects. Natural and synthetic polymers are widely used in musculoskeletal tissue engineering owing to their good biocompatibility and biodegradability. Even more promising is the use of natural and synthetic polymer composites, as well as

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15

GOLTSOV, A. V. "INTERRELATION OF THE PHYSICAL IMAGE OF "I" AND THE PSYCHOLOGICAL DEFENSE MECHANISM OF DISABLED PERSON WITH THE DEFEAT OF THE MUSCULOSKELETAL SYSTEM." Historical and social-educational ideas 8, no. 2/2 (2016): 94–97. http://dx.doi.org/10.17748/2075-9908-2016-8-2/2-94-97.

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16

Grigoricheva, L. G., I. V. Timoshnikova, A. G. Goncharenko, T. A. Akopyan, Nina A. Korenyak, and B. A. Samarin. "Dynamics of indices of primary disability of the child population due to diseases of the musculoskeletal system for the period of 2005-2014 in the Altai Territory." Medical and Social Expert Evaluation and Rehabilitation 19, no. 4 (2016): 191–94. http://dx.doi.org/10.18821/1560-9537-2016-19-4-191-194.

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The level of disability, along with the indices of the infant mortality rate, morbidity rate, physical development and health demographic processes is a basic index of child health, reflecting the level of economic and social well-being of the country. In the Russian Federation children with disabilities make up, according to various estimates, from 1.5-2.5 to 4.5% of the child population. In the structure of the primary disability of children in the Altai Krai the share of disabled children due to musculoskeletal system pathology in 2005-2014 varied from 13.2% to 26.0%. The level of the prima

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17

Bodnaruk, N.I., N.I. Smolyar, N.L. Chukhray, O.O. Mashkarinets та I.V. Gan. "Аssociation between incidence of caries of temporary teeth and pathology of the musculoskeletal system in preschool children, considering biochemical markers of connective tissue metabolism". Medicni perspektivi 27, № 2 (2022): 138–45. https://doi.org/10.26641/2307-0404.2022.2.260290.

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The aim is study biochemical markers of connective tissue metabolism in children with musculoskeletal disorders and their association with dental caries of temporary teeth. There were examined 232 children at the age of 5 (202 children with musculoskeletal disorders and 30 conditionally healthy children without somatic pathology). Among children with musculoskeletal disorders 68 (33.66%) had flat feet, 59 (29.21%) – postural impairment and 75 (37.13%) – combined pathology of the musculoskeletal sestem. For further research, the children were divided into three groups, 30 people in

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18

Sevostyanova, O. "Self-control as a personal resource for restoring social activity in patients after endoprosthetics of major joints." Glavvrač (Chief Medical Officer), no. 1 (January 1, 2020): 64–69. http://dx.doi.org/10.33920/med-03-2001-07.

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Limitations of the motor sphere as the most severe consequences of diseases of the musculoskeletal system drastically reduce the quality of life. The WHO statistics shows that 80 % of the population, the majority of which are the people of working age, suffer from various diseases of the musculoskeletal system. The proportion of patients of working age who have limitations of the musculoskeletal system increased after the adoption of the law on raising the retirement age, which makes the problem of their treatment and rehabilitation even more important. Great economic damage requires the searc

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19

Mykhaylov, B., O. Kudinova, and I. Shestak. "System of combined psychotherapeutic and physical rehabilitation of children with cyber addiction." European Psychiatry 66, S1 (2023): S140—S141. http://dx.doi.org/10.1192/j.eurpsy.2023.352.

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IntroductionContemporary children practically live in cyberspace, constantly using various devices,and many of them have an addiction that leads to violations of their mental and physical formation.ObjectivesBased on the mental and the physical examination of children suffering on cyber addiction with the sings of clinical manifestations determine the targets and form of ccmbined correctional rehabilitation system.MethodsThe clinical investigation based on psychiatric examination with the narrative motivation interview,psychological examination by Eysenck “extra/introversion”test and physical

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20

Morozova, E., Svetlana Artemyeva, E. Zhuravleva, and O. Sherchenkova. "Features of Perception of Own Body by Persons with Health Limitations." Scientific Research and Development. Socio-Humanitarian Research and Technology 8, no. 4 (2020): 45–48. http://dx.doi.org/10.12737/2587-912x-2020-45-48.

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According to the World Health Organization, about one fifth of the total number of people with disabilities are people with lesions of the musculoskeletal system, which occurred as a result of various injuries in adulthood. In their psychological essence, they are the cause of a serious and hard-lived non-regulatory crisis of personal development, which requires from her enormous internal efforts to restore optimal interaction with other people and with society as a whole. The defeat of the musculoskeletal system necessarily entails a violation of the morphological and functional characteristi

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21

Karateev, A. E., A. M. Lila, N. V. Zagorodni, and E. Yu Pogozheva. "Damage to periarticular soft tissues in real clinical practice: frequency, nature, effectiveness of non - steroidal anti - inflammatory drugs." Terapevticheskii arkhiv 91, no. 12 (2019): 21–28. http://dx.doi.org/10.26442/00403660.2019.12.000377.

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Damage to periarticular soft tissues is a common pathology that causes severe pain and impaired function of the musculoskeletal system. Aim. To determine the frequency, nature and clinical features of damage to periarticular soft tissues in real clinical practice, as well as the effectiveness of non - steroidal anti - inflammatory drugs (NSAIDs) in the debut of treatment of this pathology. Materials and methods. During the observational study, the frequency of defeat of the periarticular soft tissues in the structure of visits to 68 outpatient orthopedic surgeons in different cities of Russia

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22

Ma, Shang, Adrienne E. Dubin, Luis O. Romero, et al. "Excessive mechanotransduction in sensory neurons causes joint contractures." Science 379, no. 6628 (2023): 201–6. http://dx.doi.org/10.1126/science.add3598.

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Distal arthrogryposis (DA) is a collection of rare disorders that are characterized by congenital joint contractures. Most DA mutations are in muscle- and joint-related genes, and the anatomical defects originate cell-autonomously within the musculoskeletal system. However, gain-of-function mutations in PIEZO2, a principal mechanosensor in somatosensation, cause DA subtype 5 (DA5) through unknown mechanisms. We show that expression of a gain-of-function PIEZO2 mutation in proprioceptive sensory neurons that mainly innervate muscle spindles and tendons is sufficient to induce DA5-like phenotype

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23

Kelly, D. "BIOFABRICATION AND 3D BIOPRINTING STRATEGIES FOR MUSCULOSKELETAL TISSUE REGENERATION." Orthopaedic Proceedings 106-B, SUPP_1 (2024): 128. http://dx.doi.org/10.1302/1358-992x.2024.1.128.

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Our musculoskeletal system has a limited capacity for repair. This has led to increased interest in the development of tissue engineering and biofabrication strategies for the regeneration of musculoskeletal tissues such as bone, ligament, tendon, meniscus and articular cartilage. This talk will demonstrate how different musculoskeletal tissues, specifically cartilage, bone and osteochondral defects, can be repaired using emerging biofabrication and 3D bioprinting strategies. This will include examples from our lab where cells and/or growth factors are bioprinted into constructs that can be im

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Al-Musawi, Bassam M., Ali M. Khalid, Nadin A. Kamal, and Maha Z. Muneer. "Congenital Anomalies in Neonates: Findings from Six Baghdad Hospitals." Journal of the Faculty of Medicine Baghdad 67, no. 1 (2025): 85–96. https://doi.org/10.32007/jfacmedbaghdad2462.

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Background: Birth defects are the leading cause of both neonatal and post-neonatal deaths, as an estimated 240,000 neonates die in their first month of life worldwide each year. In Iraq, local studies have shown varying frequencies and types of congenital anomalies. Objectives: To provide new insight into the incidence and types of congenital anomalies and to explore their possible risk factors in Baghdad City. Methods: In this cross-sectional observational study, a total of 2007 neonates were enrolled from six hospitals in Baghdad during the period extending between September and December 202

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Reece, Albert Stuart, and Gary Kenneth Hulse. "Cannabis Teratology Explains Current Patterns of Coloradan Congenital Defects: The Contribution of Increased Cannabinoid Exposure to Rising Teratological Trends." Clinical Pediatrics 58, no. 10 (2019): 1085–123. http://dx.doi.org/10.1177/0009922819861281.

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Rising Δ9-tetrahydrocannabinol concentrations in modern cannabis invites investigation of the teratological implications of prenatal cannabis exposure. Data from Colorado Responds to Children with Special Needs (CRCSN), National Survey of Drug Use and Health, and Drug Enforcement Agency was analyzed. Seven, 40, and 2 defects were rising, flat, and falling, respectively, and 10/12 summary indices rose. Atrial septal defect, spina bifida, microcephalus, Down’s syndrome, ventricular septal defect, and patent ductus arteriosus rose, and along with central nervous system, cardiovascular, genitourin

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Rahman, Jahanara, Nasreen Sultana, and Hosne Ara Begum. "Pattern and risk factors of birth defects among the newborns: A hospital based study." Journal of Dhaka National Medical College & Hospital 21, no. 1 (2015): 32–36. https://doi.org/10.3329/jdnmch.v21i1.77831.

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Introduction :Birth defects are one of the important causes of perinatal mortality and morbidity. Methods : A cross sectional descriptive study was carried out in In-patient Department of Obstetrics and Gynaecology in Dhaka National Medical College Hospital between January 2008 and December 2008. Objectives : The objectives of the study was to determine the frequency of identifiable birth defects, to observe the types of birth defects found among the newborns and to estimate the risk factors present among the parents of birth defect babies. Results : During this study period 2990 deliveries to

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Hicham, Sallahi, and Arabi Hafid. "A Noble Structure of the Musculoskeletal System in Various Surgeries: The Fascia Lata." Saudi Journal of Medical and Pharmaceutical Sciences 9, no. 08 (2023): 513–17. http://dx.doi.org/10.36348/sjmps.2023.v09i08.003.

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Objective: The objective of this work is to list the surgeries using the fascia lata. Background: The fascia lata finds a place in decayed tissues. The indications are getting wider and wider. Method: We used the PubMed database with the following words: fascia lata, ilio-tibial band, fascia lata and surgery, ilio-tibial band and surgery, fascia lata and reconstruction, ilio-tibial band and reconstruction. Results: Fascia lata is used in the reconstruction of anatomical defects. Specifically, it is used in: Hip to supplement abduction- Shoulder in glenohumeral instability, repair of the cap- H

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Alymbaev, E., G. Zhumagulova, and G. Kozhonazarova. "Congenital Heart Defects as One of the Causes of Perinatal Mortality." Bulletin of Science and Practice 10, no. 10 (2024): 135–40. http://dx.doi.org/10.33619/2414-2948/107/14.

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Congenital malformations are one of the most common causes of infant mortality and disability in children, and congenital heart defects (CHD) occupy a leading place in the structure of all developmental anomalies. The article presents data from a retrospective analysis of charts of children who died from complex congenital heart defects and congenital heart defects in combination with multiple developmental defects. An analysis of the pathological examination cards of 102 children from 0 to 2 years old who died in maternity hospitals and children's hospitals in Bishkek was carried out. The sel

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Voronin, S. V. "Prevalence and features of polymorbidity of servicemen of different age groups according to the results of their medical examination to determine the category of fitness for military service." Bulletin of the Russian Military Medical Academy 22, no. 1 (2020): 39–44. http://dx.doi.org/10.17816/brmma25965.

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The prevalence of polymorbidity and its features in military personnel of various age groups was studied. It has been established that polymorbidity during medical examinations of military personnel occurs in all age groups, increasing with age. For each age group of military personnel, its characteristic polymorbidity models are formed. So, in the age group up to 35 years, polymorbidity occurs in one third of the examined and is characterized by both functional disorders of the circulatory system and digestive organs, and the presence of organic pathology of the circulatory system (congenital

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Pavlyuchenko, А. К. "CHANGES OF EYE AT ANKYLOSING SPONDYLARTHRITIS." Medical Science of Ukraine (MSU) 13, no. 3-4 (2017): 46–51. http://dx.doi.org/10.32345/2664-4738.3-4.2017.07.

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Relevance. At present, all variants of changes in the eye in case of ankylosing spondylitis have not been determined, their relationship to the musculoskeletal system has not been studied, the degree of influence of certain eye diseases on the clinical and X-ray manifestations of ankylosing spondylitis and their prognostic significance remains unknown. Objective. The purpose: to study different variants of changes in the eye in case of ankylosing spondylitis, their relationship to the defeat of the musculoskeletal system, the degree of influence of certain eye diseases on the clinical an

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Aryal, S., K. Panthee, and K. Neupane. "Clinical Study on Congenital Birth Defects in a Tertiary Hospital, Western Nepal." Devdaha Medical Journal 5, no. 2 (2023): 20–26. http://dx.doi.org/10.3126/dmj.v5i2.69795.

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Introduction: Congenital Birth Defect (CBD) is one of the commonly encountered problems in neonatal period and major birth defects contribute significantly to neonatal morbidity and mortality. Minor anomalies are frequently seen in newborn which are not detrimental to health but may be associated with major defects serving as a clue for diagnosing more serious underlying defect. Our purpose of study is to determine burden of CBDs, clinical profile and outcome of those neonates born with CBDs admitted in Neonatal Intensive care Unit (NICU) and Obstetric Unit of Devdaha Medical College. Methods:

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Avdeychik, Natalia V., Sergey I. Golyana, Denis Yu Grankin, Andrey V. Safonov, Tatyana I. Tikhonenko, and Natalia S. Galkina. "Possibilities of using microsurgical autotransplantation of tissue complexes in children." Pediatric Traumatology, Orthopaedics and Reconstructive Surgery 8, no. 4 (2021): 437–50. http://dx.doi.org/10.17816/ptors17896.

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Background. Applications of traditional treatment methods in children with congenital and acquired pathology of the musculoskeletal system are often limited, as wound defects of significant area and depth with a soft tissue and bone deficit may occur during the reconstruction of the segment. Microsurgical techniques, including autotransplantation of blood-supplied tissue complexes, make it possible to realize the aims of musculoskeletal segment reconstruction and reduce surgical treatment time. Aim. This study aimed to perform a retrospective (statistical) analysis of using microsurgical

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Avdeychik, Natalia V., Sergey I. Golyana, Denis Yu Grankin, Andrey V. Safonov, Tatyana I. Tikhonenko, and Natalia S. Galkina. "Possibilities of using microsurgical autotransplantation of tissue complexes in children." Pediatric Traumatology, Orthopaedics and Reconstructive Surgery 8, no. 4 (2021): 437–50. http://dx.doi.org/10.17816/ptors17896.

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Background. Applications of traditional treatment methods in children with congenital and acquired pathology of the musculoskeletal system are often limited, as wound defects of significant area and depth with a soft tissue and bone deficit may occur during the reconstruction of the segment. Microsurgical techniques, including autotransplantation of blood-supplied tissue complexes, make it possible to realize the aims of musculoskeletal segment reconstruction and reduce surgical treatment time. Aim. This study aimed to perform a retrospective (statistical) analysis of using microsurgical

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34

Ma, S., A. Dubin, L. Romero, et al. "THE ROLE OF MECHANOSENSORY NEURONS IN MUSCULOSKELETAL DISEASES." Orthopaedic Proceedings 106-B, SUPP_1 (2024): 71. http://dx.doi.org/10.1302/1358-992x.2024.1.071.

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Distal arthrogryposis (DA) is a collection of rare developmental disorders characterized by congenital joint contractures. Most arthrogryposis mutations are in muscle- and joint-related genes, and the anatomical defects originate cell-autonomously within the musculoskeletal tissues. However, gain-of-function (GOF) mutations in PIEZO2, a principal mechanosensor in somatosensation, cause DA subtype 5 via unknown mechanisms. We show that expression of a GOF PIEZO2 mutation in proprioceptive sensory neurons mainly innervating muscle spindles and tendons is sufficient to induce DA5-like phenotypes

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Mullenix, Cristina, Madison Ballman, Haobin Chen, et al. "Joint-Predominant Rheumatic Complications of Immune Checkpoint Inhibitor Therapy in Patients with Thymic Epithelial Tumors." Oncologist 27, no. 4 (2022): e353-e356. http://dx.doi.org/10.1093/oncolo/oyac026.

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Abstract Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced cancers. However, activation of the immune system can occasionally cause life-threatening toxicity involving critical organs. Induction of immune-mediated toxicity is a significant concern for patients with thymic epithelial tumors (TETs) due to defects in immune tolerance. An increased risk of skeletal and cardiac muscle inflammation following treatment with ICIs is well recognized in patients with advanced TETs. However, uncommon musculoskeletal and rheumatic complications can also occur. The cases pre

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Umer, Masood, Hafiz Muhammad Umer, Irfan Qadir, et al. "Autoclaved Tumor Bone for Skeletal Reconstruction in Paediatric Patients: A Low Cost Alternative in Developing Countries." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/698461.

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We reviewed in this series forty patients of pediatric age who underwent resection for malignant tumors of musculoskeletal system followed by biological reconstruction. Our surgical procedure for reconstruction included (1) wide en bloc resection of the tumor; (2) curettage of tumor from the resected bone; (3) autoclaving for 8 minutes (4) bone grafting from the fibula (both vascularized and nonvascularized fibular grafts used); (5) reimplantation of the autoclaved bone into the host bone defect and fixation with plates. Functional evaluation was done using MSTS scoring system. At final follow

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Romeo, Domenico M., Alessandro Specchia, Alfonso Fasano, et al. "Treatment of Dystonia Using Trihexyphenidyl in Costello Syndrome." Brain Sciences 10, no. 7 (2020): 450. http://dx.doi.org/10.3390/brainsci10070450.

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Costello syndrome (CS), a rare syndrome with multisystemic involvement inherited as a dominant trait, is characterized by developmental delay, coarse facial appearance, cardiac defects including hypertrophic cardiomyopathy, skin abnormalities, brain complications, and a predisposition to certain malignancies. The musculoskeletal system is particularly affected in CS, with peculiar orthopedic anomalies that impact posture and gait. Dystonia has been recently documented to contribute to abnormal postures and musculoskeletal anomalies characterizing CS, suggesting the possible use of pharmacologi

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Lukianchyk, S. M., I. V. Chelpanova, O. O. Adamovych, et al. "Analysis of the frequency of manifestation of isolated and combined developmental defects of the musculoskeletal system of primery school-aged children." Modern pediatrics. Ukraine, no. 1(137) (February 28, 2024): 52–57. http://dx.doi.org/10.15574/sp.2024.137.52.

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Over the past few decades, there has been a significant decrease in the number of healthy children, while the number of children with chronic illnesses, developmental disorders, various forms of postural issues, and scoliosis has significantly increased. Purpose - to determine the frequency of manifestation of developmental abnormalities in the spine, chest, foot, and lower jaw, as well as detection of variations and characteristics of their combinations in younger school children to develop new and improve existing criteria for early diagnosis of musculoskeletal development disorders and the

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Barna, Miloš, Jana Čepová, Kateřina Dunovská, et al. "Chemiluminescent and Photometric Analysis of Matrix Gla Protein from Patients with a Defect of Musculoskeletal System." Chemické listy 117, no. 11 (2023): 694–700. http://dx.doi.org/10.54779/chl20230694.

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Matrix Gla protein (MGP) is a circulating protein with a low molecular weight that acts as a natural inhibitor of calcification. It belongs to the group of vitamin K‑dependent proteins. For its proper function, MGP must undergo vitamin K-dependent carboxylation and phosphorylation. Its main function is the prevention of soft-tissue calcification. It requires vitamin K2 as a cofactor for gamma glutamyl carboxylase. Vitamin K insufficiency is manifested by cardiovascular diseases, insufficient mineralization of bone tissue and the formation of calcifying deposits in soft tissues. The aim of this

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DZIKOWSKI, ANDRZEJ, and JÓZEF SZAREK. "Physical latent defects of the musculoskeletal system of dogs: The scope of the veterinary expert assessment under current legal definitions in consumer sales. A case study." Medycyna Weterynaryjna 81, no. 4 (2025): 193–98. https://doi.org/10.21521/mw.6997.

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In this case study, two veterinary expert opinions on latent physical defects of dogs sold were analysed. In both cases, a veterinarian was appointed as a court expert, primarily to determine whether a given animal had a disease and when it developed. However, the tasks of the veterinary expert were not limited to this. Case study analysis combined with legal analysis offerred a broader perspective on the sale of dogs in which the buyer is a consumer and the seller is a professional breeder. The study revealed defects understood as physical pathologies and deviations from the state of health o

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Aghyppo, Oleksandr, Irina Pomeshchikova, Ludmila Filenko, Vladlena Pasko, Romana Sirenko, and Oleksandr Poproshaiev. "The Effect of Physical Exercises and Ball Games on the Static Balance of Students with Musculoskeletal Disorders." Sport Mont 19, no. 3 (2021): 83–88. http://dx.doi.org/10.26773/smj.211020.

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This research aims to detect the effect of using exercises and ball games in physical education on the stat- ic balance of students with musculoskeletal disorders. The research involved 40 secondary school students aged 16-19, who were divided into two groups. Students have disabilities with mild and average forms of illness. The level of static balance was determined by the indicators of a modified Romberg test, which was carried out at the beginning and the end of the training lesson. The research was carried out for 18 months. It was established that the indicators of students of two groups

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Shipova, Natalia S. "Personal characteristics and internal picture of the defect in disabled adults." Vestnik of Kostroma State University. Series: Pedagogy. Psychology. Sociokinetics 27, no. 2 (2021): 128–34. http://dx.doi.org/10.34216/2073-1426-2021-27-2-128-134.

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The presented article describes the results of the study of the components of the internal picture of the defect and their relationship with personality traits in adults with deficient dysontogeny type (respondents with visual impairment, speech impairment, musculoskeletal system impairment, hearing impairment). At the theoretical level, an analysis of the possibilities of a defect to determine violations of personal development and personal changes is presented. We noted a greater number of connections in the group of people with visual impairments, and the least in the group of people with s

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Kimura, Wataru, Masashi Machii, XiaoDong Xue, et al. "Irxl1 mutant mice show reduced tendon differentiation and no patterning defects in musculoskeletal system development." genesis 49, no. 1 (2010): 2–9. http://dx.doi.org/10.1002/dvg.20688.

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Voloshyn, O. I., O. V. Glubochenko, I. V. Pankiv, V. G. Glubochenko, and I. V. Prysiazhniuk. "Rheumatic manifestations of thyroid pathology. Literature review." Clinical Endocrinology and Endocrine Surgery, no. 1 (April 6, 2022): 57–67. http://dx.doi.org/10.30978/cees-2022-1-57.

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Thyroid disease can be accompanied by a variety of rheumatic manifestations, ranging from early growth defects during infancy to adult manifestations such as arthralgias, myalgias, myopathy, acropachy, arthritis, osteoporosis. Objective — to provide a summarizing current literature on the analysis of a variety of musculoskeletal disorders in hyperthyroidism and hypothyroidism and possible mechanisms that explain this connection. Materials and methods. The authors conducted a systematic literature search for relevant Englishlanguage publications published between June 2011 and October 2021 in M

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Samoshkin, Igor I., and Ilya F. Vilkovysky. "Correction of long bone deformities in dogs. Veterinary methodology CORA. Basic principles." Veterinariya, Zootekhniya i Biotekhnologiya 2, no. 123 (2024): 50–64. http://dx.doi.org/10.36871/vet.zoo.bio.202402004.

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Deformities of the long bones of the limbs in dogs are a common pathology of the musculoskeletal system in dogs, have a pronounced functional and cosmetic defect and require complex surgical treatment. Diagnosis of deformities and planning their treatment is an integral part of successful treatment of curvatures of the limb bones. This work represents an extrapolation into veterinary orthopedic practice of the CORA medical methodology, modified and expanded to take into account species differences between humans and dogs.

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Kuo, Tom K., Jennifer H. Ho, and Oscar K. Lee. "Mesenchymal Stem Cell Therapy for Nonmusculoskeletal Diseases: Emerging Applications." Cell Transplantation 18, no. 9 (2009): 1013–28. http://dx.doi.org/10.3727/096368909x471206.

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Mesenchymal stem cells are stem/progenitor cells originated from the mesoderm and can different into multiple cell types of the musculoskeletal system. The vast differentiation potential and the relative ease for culture expansion have established mesenchymal stem cells as the building blocks in cell therapy and tissue engineering applications for a variety of musculoskeletal diseases, including repair of fractures and bone defects, cartilage regeneration, treatment of osteonecrosis of the femoral head, and correction of genetic diseases such as osteogenesis imperfect. However, research in the

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Ponyrko, A. O. "THE EFFECT OF CHRONIC HYPERGLYCEMIA ON THE STATE OF MUSCULOSKELETAL SYSTEM (LITERATURE REVIEW)." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 21, no. 1 (2021): 184–87. http://dx.doi.org/10.31718/2077-1096.21.1.184.

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Diabetes mellitus is a metabolic disorder that today has become a threatening problem for human health. Its prevalence has been constantly increasing throughout the world over the past decades. Diabetes mellitus is regarded as an incurable metabolic disorder characterized by hyperglycemia, which is caused by defects in insulin secretion. This disease annually affects almost 3% of the total population of the planet. Chronic hyperglycemia causes dysfunction of various organs of the body, such as the eyes, kidneys, heart, blood vessels, and nerves. The most common complications of diabetes includ

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Fan, Jingzhi, Keyvan Abedi-Dorcheh, Asma Sadat Vaziri, et al. "A Review of Recent Advances in Natural Polymer-Based Scaffolds for Musculoskeletal Tissue Engineering." Polymers 14, no. 10 (2022): 2097. http://dx.doi.org/10.3390/polym14102097.

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The musculoskeletal (MS) system consists of bone, cartilage, tendon, ligament, and skeletal muscle, which forms the basic framework of the human body. This system plays a vital role in appropriate body functions, including movement, the protection of internal organs, support, hematopoiesis, and postural stability. Therefore, it is understandable that the damage or loss of MS tissues significantly reduces the quality of life and limits mobility. Tissue engineering and its applications in the healthcare industry have been rapidly growing over the past few decades. Tissue engineering has made sig

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Choi, E. G. "‘Long Covid’ (post-covid syndrome): Mechanism of occurrence, diagnosis and rehabilitation." Medical alphabet, no. 41 (January 9, 2022): 20–26. http://dx.doi.org/10.33667/2078-5631-2021-41-20-26.

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The article is devoted to the study of an urgent problem of modern humanity – the fight against a pandemic caused by a new coronavirus infection, namely: the study of the mechanism of development of ‘long Covid’ (post-covid syndrome), a new clinical and laboratory method of its diagnosis, issues of drug and non-drug rehabilitation of patients who have suffered COVID‑19. The paper describes the etiopathogenesis of post-covid syndrome (PS), the distinctive features of which are the defeat of the cardiovascular, respiratory, nervous, digestive, immune systems of the body, ENT organs and musculosk

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Marshall, Elizabeth G., Lenore J. Gensburg, Debra A. Deres, Nanette S. Geary, and Michael R. Cayo. "Maternal Residential Exposure to Hazardous Wastes and Risk of Central Nervous System and Musculoskeletal Birth Defects." Archives of Environmental Health: An International Journal 52, no. 6 (1997): 416–25. http://dx.doi.org/10.1080/00039899709602220.

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