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DUSOV, Abdimurod Kholmurodovich, and Ulugbek Usmonovich OCHILOV. "CLINICAL AND CATAMNESTIC FEATURES FORMATION OF A DEFECT IN PATIENTS WITH PARANOID SCHIZOPHRENIA. (LITERATURE REVIEW)." Journal of biomedicine and practice 7, no. 5 (2022): 5. https://doi.org/10.5281/zenodo.7392833.
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Today, there is no doubt that paranoid schizophrenia is a neurodevelopmental disease of multifactorial origin. Many mechanisms can interact to produce psychotic manifestations, including genetic factors, viral diseases, immunological dysfunctions, obstetric complications, or environmental determinants that cause early stress. The defects seen in paranoid schizophrenia can lead to reduced emotional communication and response, emotional coldness, emotional impoverishment, and inadequate emotional relationships. It is also expressed by a decrease in mental activity, a decrease in the level of needs, activity - a decrease in passivity and energy potential, apathy, autism, inability to affective relationships, a decrease in empathy and their variability.
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Bokhan, N. A., G. Yu Selivanov, A. A. Salnikov, and K. A. Blonsky. "Mental Disorders Associated with the Abuse of Synthetic Cannabinoids (Spices)." Psikhiatriya 19, no. 2 (2021): 6–16. http://dx.doi.org/10.30629/2618-6667-2021-19-2-6-16.
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Introduction: the abuse of synthetic cannabinoids may trigger the development of mental disorders characterized by distortions of disease processes that can cause incorrect diagnosis.Objective: to study the phenomenon of the abuse of synthetic cannabinoids (Spice) as a trigger psychotic episode in psychiatric patients (with schizophrenia and personality disorders) and risk factors for developing paranoid schizophrenia.Patients and research methods: 291 men were examined: 241 with dependence on synthetic cannabinoids — 101 of them were diagnosed with personality and behavior disorders in adulthood, 140 with a diagnosis of paranoid schizophrenia and 50 with a diagnosis of paranoid schizophrenia without drug dependence.Research methods: clinicalpsychopathological, psychometric (SANS, CGI, MMPI), follow-up, statistical R (R version 3.2.4).Results: intoxication conditions caused by synthetic cannabinoids can provoke the development of psychotic episodes and be a trigger for the manifestation of schizophrenia. There are four variants of narcotic intoxication: delirious, schizophrenic, with pseudo-hallucinations, with delirium. The personalities of patients addicted to synthetic cannabinoids are similar in the prevalence of emotionally unstable, rigid, introverted, deviant traits. Patients with personality disorders, dependent on synthetic cannabinoids, differed from typical drug addicts in such patterns of behavior as disorganization, conflict, unpredictability, spontaneity, thoughtlessness of actions, impulsivity, and nonconformity. The stigmatizing signs of the schizophrenic process in patients who are dependent on synthetic cannabinoids are the symptoms of abulia–apathy of mild severity. Patients with schizophrenia, dependent on synthetic cannabinoids, differed from patients without dependence on drugs by the phenomenon of the absence of an emotional defect expressed in the expressiveness of emotions, the desire for communication.Conclusion: the phenomenon of synthetic cannabinoid abuse is a trigger of a psychotic episode in both schizophrenic patients and those with personality disorders in whom antisocial, schizoid and paranoid personality traits prevail. The abuse of synthetic cannabinoids is a risk factor for the development of paranoid schizophrenia, which differs from schizophrenia without drug dependence by a mild degree of stigmatizing symptoms of abulia–apathy and social activity during periods of short-term remissions.
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Chembaev, B. R., and S. Z. Eshimbetova. "Relationship of clinical presentation and psychopathological mechanisms at the commitment of grave socially dangerous acts by schizophrenic patients." Kazan medical journal 96, no. 4 (2015): 536–42. http://dx.doi.org/10.17750/kmj2015-536.
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Aim. To study the relationship of clinical presentation and psychopathological mechanisms at the commitment of grave socially dangerous acts by schizophrenic patients.
 Methods. The sample consisted of 201 schizophrenic patients who have committed grave socially dangerous acts targeted at the life and health of people. The investigation that included social-demographic, anamnestic and clinical data was performed. The sample was divided into three subgroups according to psychopathological mechanisms of grave socially dangerous acts commitment, determined by authors: unconditional-psychotic mechanism (n=46), conditional-psychotic mechanism (n=76) and negative-personality mechanism (n=79).
 Results. In patients with the unconditional-psychotic mechanism, the acute psychopathological symptoms such as catatonic, affective and delusional syndromes, acute delusional conditions were prevalent by the time of commitment of socially dangerous acts. In patients with this mechanism of catatonic schizophrenia, remittent course or intermittent-progressive course with the increased production of negative symptoms in remission were significantly more common. In patients with the conditional-psychotic mechanism, paranoid schizophrenia was prevalent, which was characterized by a continuous course without remissions, delusions without hallucinations, or chronic paranoid states. In patients with the negative-personality mechanism, the major psychopathological syndromes were defect and final states; residual schizophrenia and paranoid form of schizophrenia were common, intermittent-progressive course with stable but not increasing negative symptoms had dominated. The highest average duration of the disease at the time of committing a socially dangerous action was associated with the negative-personality mechanism. It was 13.56±9.00 years, which is considerably higher than at unconditional-psychotic mechanism (7.02±7.40 years) and at conditional-psychotic mechanism (7.38±8.35 years).
 Conclusion. When developing treatment and prevention measures, it is necessary to take into account the psychopathological mechanisms of commitment of grave socially dangerous acts combined with data of clinical presentation.
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Vinnikova, I. N., I. V. Kravchenko, I. I. Chizhikov, and V. G. Sidorov. "Analysis of the Effectiveness of Psychopharmacotherapy in Patients with Paranoid Schizophrenia with Non-Suicidal Autoaggression and Deficit Personality Changes." Doctor.Ru 23, no. 7 (2024): 56–62. http://dx.doi.org/10.31550/1727-2378-2024-23-7-56-62.
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Aim. A comparative analysis of the effectiveness of neuroleptics in patients with paranoid schizophrenia with deficit changes at the personal level and non-suicidal auto-aggressive actions (NAA) who are on compulsory treatment. Design. Full-scale non-randomized longitudinal study Materials and methods. The study included 237 patients with paranoid schizophrenia during maintenance therapy: 76 people were on risperidone monotherapy, 61 patients received quetiapine, and 100 patients took haloperidol. The clinical effectiveness of therapy was determined by comparative analysis of the frequency of exacerbation of psychotic symptoms, the severity of negative disorders, the frequency of acts of non-suicidal auto-aggression and the level of social functioning. In addition to clinical observation, the Scale of Negative Psychopathology (SANS) and the Social Functioning Scale (PSP) were used. Fisher's test and ANOVA analysis of variance were used to statistically evaluate the data. Results. All drugs helped reduce the incidence of exacerbation of psychotic disorders, while only with the use of risperidone and haloperidol positive changes in antipsychotic activity were statistically significant (p < 0.01). All drugs helped reduce the severity of negative disorders. When taking risperidone, a statistically significant decrease in disorders associated with flattening and rigidity of affect and attention was noted (p ≤ 0.05). Haloperidol caused a decrease in flattening and rigidity of affect, attention and speech disorders, and apato-abulic syndrome (p ≤ 0.05). All drugs statistically significantly reduced the risk of NAA (p ≤ 0.05), and also contributed to an increase in the level of social functioning of patients, and in patients taking haloperidol, statistically significant changes in this indicator appeared earlier. By the end of the study, while taking each of the drugs included in the study, statistically significant positive changes in the studied parameters were noted (p ≤ 0.05). Conclusion. The first-line drug for patients with paranoid schizophrenia with deficient personality changes and NAA who are on compulsory treatment is haloperidol. An alternative treatment method for this group of patients may be the administration of risperidone. Keywords: schizophrenic defect at the personal level, neuroleptics, paranoid schizophrenia, non-suicidal auto-aggression.
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Khommyatov, M. R., I. G. Smolentseva, S. A. Golubev, A. V. Goryunov, and M. A. Samushiya. "Schizophrenic spectrum disorders and Parkinson’s disease." S.S. Korsakov Journal of Neurology and Psychiatry 125, no. 3 (2025): 136. https://doi.org/10.17116/jnevro2025125031136.
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The case demonstrated the difficulties of differential diagnosis and selection of therapy in patients with Parkinson’s disease and schizophrenic spectrum disorders. A clinical case of a 45-year-old male with a 10-year history of paranoid schizophrenia, with hallucinatory paranoid attacks and a steady increase in negative symptoms in the form of apato-abulic defect, is presented. The use of antipsychotics was associated with neuroleptic parkinsonism, well responding to therapy, and reduced when the patient discontinued antipsychotic therapy. However, after 10 years of schizophrenia, Parkinson’s syndrome manifested without neuroleptics; the antipsychotic therapy led to a sharp deterioration in motor status. A neurologist specializing in extrapyramidal disorders made the following diagnosis: Parkinson’s disease, mixed form, Hoehn and Yahr stage 2. According to the neurologist’s recommendation, typical neuroleptics were replaced with quetiapine, and levodopa was added to therapy. During treatment, the parkinsonism symptoms significantly decreased without an increase in psychotic symptoms. The clinical case illustrates the challenges in diagnosing Parkinson’s disease in a patient with schizophrenia and the complexity of treating such comorbidities. When managing such patients, close collaboration between psychiatrists and neurologists is necessary to make an accurate diagnosis and select the optimal therapy. The introduction of the multidisciplinarity principle will make it possible to achieve the fastest diagnosis and selection of balanced therapy in this category of patients.
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Dhakouani, S., R. Kammoun, C. Aissaoui, M. Karoui, and F. Ellouz. "Marfan syndrome and schizophrenia : a case report and literature review." European Psychiatry 65, S1 (2022): S461. http://dx.doi.org/10.1192/j.eurpsy.2022.1171.
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Introduction Marfan syndrome is an autosomal dominant systemic disorder with connective tissue defects in multiple organ systems. Cardinal manifestations of this syndrome involve the cardiovascular, the skeletal and the ocular system. Interestingly, many cases of patients with Marfan syndrome and schizophrenia have been reported. Objectives Discuss the etiological link between Marfan syndrome and schizophrenia Methods Presentation of a clinical case illustrating the comorbidity between schizophrenia and marfan syndrome. A search was conducted in PubMed database using the terms : schizophrenia AND Marfan syndrome. Results Ms JW a 36-year- old single women, she had schizophrenia since the age of 20 years, she was hospitalized in our service for psychotic relapse in a context of treatment discontinuation. She had a personal history of persistence of the ductus arteriosus for which she had been operated during her childhood, a scoliosis operated and multiple pathological fractures. On mental status examination, she was distressed and hallucinated, She had disorganized thought processes and a paranoid delirium. On physical examination, she had features suggestive of Marfan syndrome such as crowded teeth, a high arched palate, arachnodactyly , hyperlaxity and a high myopia. We don’t dispose genetic evaluation for marfan syndrom because of the nonavaibility of facilities to perform genetic analysis. Several studies have indicated that psychiatric symptoms might be part of the clinical profiles of marfan syndrom. However, their relationship and underlying pathogenesis are not easily clarified. Conclusions Co-occurrence of marfan syndrom and schizophrenia might be explained by some shared etiological pathways between both disorders. Disclosure No significant relationships.
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Mendelevich, Vladimir D., Alena A. Katok, Tangyul Z. Beybalaeva, Andrey A. Kapralov, and Radzhab R. Abakarov. "Dissociation, “OCD IN REVERSE” and unfulfilled schizophrenia. Case of Alsu B." Neurology Bulletin LV, no. 4 (2024): 35–49. http://dx.doi.org/10.17816/nb624043.
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The article describes a rare clinical case of severe histrionic personality disorder featuring manifestations of an atypical obsessive-compulsive disorder (“obsessive-compulsive disorder in reverse”), which led to an erroneous diagnosis of schizophrenia and classification of the patient as disabled. Over an eight-year period of psychiatric observation, the girl was given many different diagnoses in leading Russian and foreign clinics — from somatoform, hypochondriac and obsessive-compulsive disorder to schizophreniform disorder, bipolar affective disorder and paranoid schizophrenia with an emotional and volitional defect. The article substantiates the diagnosis of histrionic personality disorder and the incorrectness of other diagnoses. The article also provides a brief review of the literature regarding the comorbidity of dissociative and obsessive-compulsive disorders.
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Flint, J., and L. H. Goldstein. "Familial calcification of the basal ganglia: a case report and review of the literature." Psychological Medicine 22, no. 3 (1992): 581–95. http://dx.doi.org/10.1017/s0033291700038046.
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SynopsisAlthough calcification of the basal ganglia is a relatively common and asymptomatic finding on cranial computed tomography, familial idiopathic calcification of the basal ganglia (ICBG) is a rare disorder with neurological and behavioural manifestations. Attention has recently been drawn to the frequency with which cases are diagnosed as schizophrenic (Cummings et al. 1983; Lowenthal, 1986; Davison, 1987). We report a family in which a mother and son have ICBG, but while the son has a paranoid schizophrenia and intellectual deterioration, the mother shows no psychiatric illness. A review of the relevant literature suggests that psychosis is not as common as usually supposed, and may only be coincidentally associated with familial ICBG. Moreover, we find little convincing evidence that familial ICBG is an independent entity; instead, and in agreement with earlier authorities (Bruyn et al. 1964), we argue that published accounts and our own cases provide evidence that the condition is related to pseudo-hypoparathyroidism (PHP) and, therefore, may be due to a defect in a guanine nucleotide binding protein.
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Ferro, Filippo Maria. "Metamorfosi di pensieri ed affetti: rileggendo Tanzi e Riva." RIVISTA SPERIMENTALE DI FRENIATRIA, no. 3 (November 2009): 97–110. http://dx.doi.org/10.3280/rsf2009-003003.
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- reading Tanzi and Riva's studies on "paranoia" (1884 - 1886) enriched by clinical cases masterly told with sharp sensibility, convey a thorough and deep analysis of an important notion in psychopathology. Their exemplary contribution is among the first definitions of the clinical picture in the context of the European psychiatric culture and its Kraepelinian inclusion in the construction of dementia praecox (schizophrenia). The Authors stand in a momentous time in the evolution of psychiatric knowledge and its needs for classifications. Their hypothesis, which follows "positivistic" ideas strong in Italy at the time, tends to interpret paranoia, its delusional expressions and, in particular, its peculiar personality organisation, in the context of the "degeneration" theory, in the belief that paranoia displays "atavistic" defects. Nevertheless, beyond this concept, linked to end of eighteenth century philosophical views, the Authors outline the subject of paranoia with precision, highlighting its essential features: the conservation of intellectual functions, despite the presence of disturbances affecting logic and language (with neologisms), and the complex interweaving of experiences caused by psychological events and existential confl icts. From this perspective, Tanzi and Riva's description maintains an undisputable importance whenever, in the superseding of nosographic stances, paranoia calls for an irreducible autonomy both in clinical practice, both in its theory.
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Belskaya, Kseniya Alekseyevna, Sergey Aleksandrovich Lytayev, and Nikita Yuryevich Kipyatkov. "Psychological peculiarities of auditory cognitive defect when psychopathology." Pediatrician (St. Petersburg) 5, no. 1 (2014): 37–43. http://dx.doi.org/10.17816/ped5137-43.
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Work is executed on faculty of normal physiology of Saint-Petersburg state pediatric medical University of the Ministry of health of Russia and St. Petersburg psycho-neurological dispensary N 1. Of the existing Arsenal of psychophysiological methods in this study, we used the original method of studying perception of auditory images and psychological analysis of the status of higher mental functions in patients suffering from paranoid schizophrenia and control group. With increasing levels of anxiety, both healthy subjects and in patients of any information provided may be assessed as important. In such circumstances, the inhibition processes touch flow reduced and insignificant background is estimated sick longer than healthy. Normal perception clean and noisy auditory images has high identifiability (95 %) and efficiency with latent period of 4.2-8.4 C. Taking into account time for вербализацию a decision and biologically significant effect on the perceived information, this time interval corresponds to the physiological norm. The effectiveness of the perception of auditory images in chronic psychopathology is within 40- 75 %, and the latent period - within 11.2-24.3 with that 2.6-2.9 times exceeds the normative time of identification. Reduction in speed and efficiency of information-analytical activities in psychopathological disorders caused, apparently, by the decrease of the functional state of stem-reticular structures included in the first structural-functional Department of the auditory analyzer. The dependence of the quality of auditory-cognitive activity not only from the functional state of cortical fields, responsible for attention, perception, recognition, remembering, but also on the state of slightly-stem systems of the brain responsible tone and reactivity of the brain. Registered reliable link of functional reduce nonspecific brain systems in violation of the neurophysiological mechanisms of perception.
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Belskaya, Kseniya Alekseyevna, Sergey Aleksandrovich Lytayev, and Nikita Yuryevich Kipyatkov. "Psychological peculiarities of auditory cognitive defect when psychopathology." Pediatrician (St. Petersburg) 5, no. 2 (2014): 88–94. http://dx.doi.org/10.17816/ped5288-94.
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Work is executed on faculty of normal physiology of Saint-Petersburg state pediatric medical University of the Ministry of health of Russia and St. Petersburg psycho-neurological dispensary N 1. Of the existing Arsenal of psychophysiological methods in this study, we used the original method of studying perception of auditory images and psychological analysis of the status of higher mental functions in patients suffering from paranoid schizophrenia and control group. With increasing levels of anxiety, both healthy subjects and in patients of any information provided may be assessed as important. In such circumstances, the inhibition processes touch flow reduced and insignificant background is estimated sick longer than healthy. Normal perception clean and noisy auditory images has high identifiability (95 %) and efficiency with latent period of 4.2-8.4 C. Taking into account time for вербализацию a decision and biologically significant effect on the perceived information, this time interval corresponds to the physiological norm. The effectiveness of the perception of auditory images in chronic psychopathology is within 40-75 %, and the latent period - within 11.2-24.3 with that 2.6-2.9 times exceeds the normative time of identification. Reduction in speed and efficiency of information-analytical activities in psychopathological disorders caused, apparently, by the decrease of the functional state of stem-reticular structures included in the first structural-functional Department of the auditory analyzer. The dependence of the quality of auditory-cognitive activity not only from the functional state of cortical fields, responsible for attention, perception, recognition, remembering, but also on the state of slightly-stem systems of the brain responsible tone and reactivity of the brain. Registered reliable link of functional reduce nonspecific brain systems in violation of the neurophysiological mechanisms of perception.
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Belskaya, Ksenia A., Yuliya V. Surovitskaya, and Sergey A. Lytaev. "Spatio-Temporal EEG Markers for Recognition Auditory Images in Norm and Psychopathology." Pediatrician (St. Petersburg) 7, no. 3 (2016): 49–55. http://dx.doi.org/10.17816/ped7349-55.
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The psychophysiological mechanisms of cognitive processes dysfunctions remain poorly understood. The purpose of this study was to modeling spatial-temporal parameters of coherent EEG assessment during auditory recognition in normal conditions and psychopathology. 40 healthy subjects and 72 patients with homogeneous psychopathological states depressive nature (average age of 34 ± 3.4 years) using the standard and original research methods were investigated. Individual-psychological characteristics and the severity of cognitive defect was evaluated according to the clinical interview, research verbal memory, the traditional methods of evaluating situational and personal anxiety, the differential diagnosis of depression. The study was conducted in St Petersburg “Psycho-Neurological Clinic No 1”. We have used the original method of studying the perception of auditory images, audiometry, computer electroencephalography with multidimensional mathematical treatment and psychological analysis of higher mental functions in patients with paranoid schizophrenia and control normal subjects. Analysis of coherence alpha- and beta-EEG rhythms in solving cognitive tasks for recognition of auditory images revealed that the functional interaction of the cortical areas normally significantly increased compared to background EEG. The features of the topography of functional relationships of alpha- and beta-EEG rhythms in the perception of auditory information are confirmed. Focuses interactions are recorded in the frontal areas. It marked the integration of these frontal zones with front associative cortex and temporal areas of the left hemisphere, as well as parietal and occipital areas of both hemispheres. At psychopathology reducing the number of coherent communications, violation of the formation of foci of coherence was registered.
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Ibrahim, M. I. M. M. N., and M. Iderapalli. "“Unraveling the Diagnostic Dilemma: Unusual Presentation of Huntington’s Disease with Predominant Psychiatric Symptoms and Late-Onset Motor Manifestations”." European Psychiatry 67, S1 (2024): S478—S479. http://dx.doi.org/10.1192/j.eurpsy.2024.994.
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IntroductionHuntington’s Disease is a neurodegenerative disease inherited in an autosomal dominant fashion.The underlying genetic defect is unstable CAG trinucleotide repeat expansion with a repeat length longer than 36 resulting in pathological aggregation of abnormal protein causing cell death.The clinical symptoms encompass 3 main domains-motor,cognitive and psychiatric.The psychiatric symptoms often in atypical form appear decades before other symptoms causing significant impact on patient’s functioning and quality of life.Here, we discuss an unusual presentation of Huntington’s Disease causing diagnostic dilemma.ObjectivesCase report discussing the unusual presentation of Huntington’s Disease.MethodsCase: Mr X is a 61 year old Caucasian male.He had an uneventful birth and early childhood attaining milestones appropriately. He experienced childhood adversity in the form of sexual abuse between ages 2-14 years. His mental health difficulties started following sexual abuse when he attempted to end his life by hanging and overdosing at age 15. He got married twice, both of which broke down. There is a history of significant alcohol abuse between ages 40-50. Following this, he had a myocardial infarction and a stroke requiring stenting.He presented to Psychiatric Outpatient Services in 2011 with auditory hallucinations, social anxiety with panic attacks, OCD type rituals, claustrophobia and feeling hot all the time. He was started on an antipsychotic medication for psychosis ,but clinically deteriorated. He started having anger outbursts, marching on the spot ,and head banging. He was diagnosed with Huntington’s Chorea in 2021 after he had developed chorea. He currently has low mood and is head banging for hours.ResultsPsychiatric symptoms in HD can span a variety of domains but most common are symptoms of frontal lobe dysfunction-disinhibition, poor attention, irritability, impulsivity and personality change. Apathy, emotional blandness and social withdrawal are also prominent features.Mr X had strong family history of Paranoid Schizophrenia (aunt and cousin).There was no family history of HD. His mental health problems started early in life with DSH, Depression and Harmful use of Alcohol. He presented predominantly with psychotic symptoms like auditory hallucinations, social anxiety, paranoia. Motor symptoms started late which he incorporated into voluntary movements like head banging which made it difficult to differentiate from deliberate self harm.ConclusionsPsychiatric symptoms constitute the core of HD. Studies have shown that though depression and personality change are typical of HD, there are number of other psychiatric symptoms that can impair quality of life. Early diagnosis and treatment of these symptoms will help patients and families to cope better with severe symptoms of this progressive disease.Disclosure of InterestNone Declared
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D. A. Sheleg, D. A., M. N. M. N. Karagyaur, K. D. K. D. Bozov, et al. "Role of CDH2 and DCHS2 genes in classification of affective-delusional and hallucinatory-paranoid psychopathological syndromes of paranoid schizophrenia." Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery), no. 1 (January 15, 2025): 80–90. https://doi.org/10.33920/med-01-2501-08.
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Positive symptoms in paranoid schizophrenia are caused by mutations in a separate group of genes common with bipolar disorder type I. This fact suggests the presence of a genetically determined substrate in severe psychopathological syndromes within paranoid schizophrenia, such as affective-delusional and hallucinatory-paranoid syndromes. Dysfunction and expression of genes involved in the processes of brain formation and development is considered one of the possible causes of mental illness. Objective. Based on the results of examining patients with paranoid schizophrenia with leading affective-delusional and hallucinatory-delusional syndromes, identify the correlation of genomic variants rs1944294‑T of the CDH2 gene, rs11935573‑G and rs12500437‑G/T of the DCHS2 gene associated with the development of paranoid schizophrenia, with a psychopathological syndrome. Material and methods. The study participants were Caucasian, were not blood relatives and lived in Russia. The diagnosis of paranoid schizophrenia (F20.00 and F20.01) was established during a clinical interview. Two groups were formed to conduct the study. The first group included patients (n=27) with an established diagnosis of paranoid schizophrenia, affective-delusional syndrome. The second group included patients (n=45) with an established diagnosis of paranoid schizophrenia, hallucinatory-paranoid syndrome. Results. Statistical analysis of the distribution of identified alleles did not reveal a significant correlation of the genomic variants rs11935573‑G of the DCHS2 gene and rs6265 of the BDNF gene with the leading psychopathological syndrome of paranoid schizophrenia. The absence of reliable results indicates the presumed absence of a role for mutations of the DCHS2 and BDNF genes in the formation of the clinical picture of affective-delusional and hallucinatory-paranoid syndromes as part of the symptom complex of paranoid schizophrenia.
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Andik Ferdiantoro, Nur Azizah AS, and Hafid Algristian. "Case Report: Paranoid Schizophrenia With Stressing Point Screening For Paranoid Schizophrenia Prognosis." International Islamic Medical Journal 3, no. 1 (2022): 21–26. http://dx.doi.org/10.33086/iimj.v3i1.2127.
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Background: Schizophrenia is a psychiatric disorder characterized by decrease or inability to communicate, reality disorders, namely hallucinations and delusions, cognitive impairment and difficulty to carry out daily activities. Paranoid schizophrenia is one of the most common types of schizophrenia and its has good prognosis among other types of schizophrenia. But the prognosis decision making for paranoid schizophrenia is influenced by the following factors: prepsychotic personality, acute or chronic, type of schizophrenia, age, administration of medication, presence or absence of precipitating factors, and heredity. Objective: This study aims to determine the prognosis of paranoid schizophrenia in case is using the factors above. The case study is based on the examination of patients in the outpatient psychiatric clinic of the Islamic Hospital of Jemursari Surabaya who have received the patient's consent. Methods: The method of diagnosis uses a pocket book for the diagnosis of mental disorders PPDGJ-III and DSM-V. Result: The results are showed that is paranoid schizophrenic patients with a poor prognosis (dubia ad malam). Conclusion: All of paranoid schizophrenia have not being a good prognosis (dubia ad bonam) because it is influeced by several factors, namely prepsychotic personality, acute or chronic, type of schizophrenia, age, administration of medication, presence or absence of trigger factors, and heredity. Keywords: Paranoid Schizophrenia, Prognosis of Paranoid Schizophrenia
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Spivak, B., N. Karny, G. Katz, et al. "Functional hemisphere imbalance in patients with paranoid or disorganized schizophrenia." European Psychiatry 11, no. 4 (1996): 175–79. http://dx.doi.org/10.1016/0924-9338(96)88387-8.
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SummaryWe assessed hemisphere function in right-handed male chronic schizophrenic patients using dichotic listening tests. We evaluated digit, tonic and transitional tests in patients with paranoid schizophrenia (n = 8), patients with disorganized schizophrenia (n = 8) and in control subjects (n = 8). The dichotic listening analysis discriminated between paranoid and disorganized schizophrenia. In disorganized schizophrenia, functional impairment of both hemispheres was demonstrated, while in paranoid schizophrenia dysfunction was more prominent in the right hemisphere. These results indicate the possible involvement of right hemisphere dysfunction in the pathophysiology of chronic paranoid schizophrenia, in contrast to dysfunction of both hemispheres in chronic disorganized schizophrenia.
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Barylnik, Y., E. Kolesnichenko, Y. Abrosimova, et al. "Clinical and genetic predictors of the severity and activity of paranoid schizophrenia." European Psychiatry 41, S1 (2017): s803. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1553.
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Clinical symptoms, course and outcomes of paranoid schizophrenia are polymorphic. Reliable predictors of severity and activity of schizophrenic process could provide clinicians important prognostic information for adequate and timely implementation of therapeutic and rehabilitative measures. Overall, 206 patients with paranoid schizophrenia were examined. Clinical predictors were collected from hospital records and interviews. BDNF gene Val66Met polymorphism (rs6265 G>A), DRD2 gene C939T polymorphism (rs6275C>T) and 5-HTR2A gene T102C polymorphism (rs6313 T>C) were studied as potential markers of prognosis for paranoid schizophrenia. Results of research testify that the DRD2 gene C939T polymorphism and 5-HTR2A gene T102C polymorphism cannot be used as predictors of the severity and activity of paranoid schizophrenia. The MetMet genotype of BDNF gene Val66Met polymorphism can be used as marker of favorable prognosis for paranoid schizophrenia. Schizoid, epileptoid, psychasthenic and conformal accentuation of personality in the premorbid, early onset of psychosis, paranoid and hallucinatory-paranoid variants of onset predicted more expressed severity of paranoid schizophrenia. These prognostic factors can be taken into account in clinical practice.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Wibowo, Dwi Cahyo Arif. "Paranoid Schizophrenia Suffered by the Lead Character on “Kotoko†Movie by Shinya Tsukamoto." Japanese Research on Linguistics, Literature, and Culture 1, no. 2 (2019): 226–37. http://dx.doi.org/10.33633/jr.v1i2.3009.
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In this research, the writer explains about paranoid schizophrenia suffered by Kotoko. The purpose of this research is to analyze the characteristics and symptoms of paranoid schizophrenia. The data were taken from “KOTOKO†movie created by Shinya Tsukamoto (2011). The method used to analyzed the data is descriptive qualitative. Within modern social society, schizophrenia is a kind of social phenomenon problem. The symptom that usually appear in paranoid schizophrenia is delusions and hallutinations. The results show that becoming a single mother, post traumatic stress, over protective individual trigger the paranoid schizophrenia.
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Calcedo-Barba, A. L., and A. Calcedo-Ordóñez. "Violence and paranoid schizophrenia." International Journal of Law and Psychiatry 17, no. 3 (1994): 253–63. http://dx.doi.org/10.1016/0160-2527(94)90029-9.
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Šulskutė, Raminta, Simona Galnaitytė, and Indrė Usonytė. "PARANOID SCHIZOPHRENIA: CASE REPORT." Health Sciences 33, no. 3 (2023): 58–59. http://dx.doi.org/10.35988/sm-hs.2023.085.
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Schizophrenia is a complex chronic mental disorder, that manifests with positive and negative symptoms, as well as disorganized behavior and cognitive changes, and affects around 1% of the population. Paranoia remains the most common delusion among patients diagnosed with schizophrenia. Although the etiology of schizophrenia remains unknown and it is thought that genetic and environmental factors contribute to its development, studies suggest that childhood bullying victimization is likely to be a significant risk factor for having paranoid ideas. The clinical case of the young man diagnosed with paranoid schizophrenia is discussed in this article.
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Khanafiah, Melly, Mariyana Eka Putri, Izzati Nadya, Risma Anita Puriani, and Rizki Novirson. "Case Report: Paranoid Schizophrenia." TSAQOFAH 5, no. 2 (2025): 1739–47. https://doi.org/10.58578/tsaqofah.v5i2.5166.
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Schizophrenia is a mental disorder characterized by distortion of reality, disorganization, and psychomotor poverty. Schizophrenia is characterized by positive symptoms such as hallucinations, delusions, bizarre behavior and thought disorders and negative symptoms such as flat or blunted affect, alogia, anhedonia and deficits in social interaction. Schizophrenia disorders persist for at least six months and there must be at least one month of symptoms. Schizophrenia affects approximately 1% of the world's population. Although schizophrenia treatment can improve symptoms, it cannot restore normal function in most patients. Treatments that can be given to schizophrenia sufferers such as oral antipsychotics, especially second-generation such as risperidone, olanzapine, aripiprazole are recommended for initial treatment of acute psychosis. Case illustration is a 27-year-old male patient with complaints of hearing voices that cannot be heard by others and making it difficult for the patient to sleep. Management of this patient was given quetiapine 2x400 mg and lorazepam 1x1 mg. The result of this patient's management is an improvement in clinical symptoms. The conclusion of this case report is that paranoid schizophrenia is a case that is easy to relapse and can even become chronic, so it is necessary to do the importance of medication compliance, appropriate social support in order to improve social function in patients.
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Siti Elita Syabaniyah and Ryan Aditya. "CASE REPORT: PARANOID SCHIZOPHRENIA." PROFESSIONAL HEALTH JOURNAL 7, no. 1 (2025): 318–23. https://doi.org/10.54832/phj.v7i1.1106.
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Schizophrenia is a mental disorder characterized by distortion of reality, disorganization, and psychomotor poverty. Schizophrenia is characterized by positive symptoms such as hallucinations, delusions, bizarre behavior and thought disorders and negative symptoms such as flat or blunted affect, alogia, anhedonia and deficits in social interaction. Schizophrenia disorders persist for at least six months and there must be at least one month of symptoms. Schizophrenia affects approximately 1% of the world's population. Although schizophrenia treatment can improve symptoms, it cannot restore normal function in most patients. Treatments that can be given to schizophrenia sufferers such as oral antipsychotics, especially second-generation such as risperidone, olanzapine, aripiprazole are recommended for initial treatment of acute psychosis. Case illustration is a 27-year-old male patient with complaints of hearing voices that cannot be heard by others and making it difficult for the patient to sleep. Management of this patient was given quetiapine 2x400 mg and lorazepam 1x1 mg. The result of this patient's management is an improvement in clinical symptoms. The conclusion of this case report is that paranoid schizophrenia is a case that is easy to relapse and can even become chronic, so it is necessary to do the importance of medication compliance, appropriate social support in order to improve social function in patients.
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Jia, Yanbin, Xin Yu, Boyu Zhang, et al. "An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population." European Psychiatry 19, no. 6 (2004): 377–79. http://dx.doi.org/10.1016/j.eurpsy.2004.07.006.
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AbstractWe performed an association study between three SNPs in the genes of 14-3-3 family and paranoid schizophrenia. SNP rs983583 G/A in the YWHAZ gene showed significant association with paranoid schizophrenia. Our study indicated that the YWHAZ gene was a potential susceptibility gene for paranoid schizophrenia in the population studied.
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Debnath, Monojit, Sujit K. Das, Nirmal K. Bera, Chitta R. Nayak, and Tapas K. Chaudhuri. "Genetic Associations between Delusional Disorder and Paranoid Schizophrenia: A Novel Etiologic Approach." Canadian Journal of Psychiatry 51, no. 6 (2006): 342–49. http://dx.doi.org/10.1177/070674370605100602.
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Objectives: Genetic associations between delusional disorder and paranoid schizophrenia are not well understood, although involvement of biological factors has been suspected. We investigated the incidence of human leukocyte antigen (HLA) class I alleles in patients with delusional disorder and paranoid schizophrenia, first, to explore a possible immunogenetic etiology of these paranoid disorders and, second, to determine whether they share similar etiologic mechanisms. Method: We employed a nested case–control study design. Psychiatric reference data were available for 38500 patients attending a hospital-based psychiatric outpatient department between 1998 and 2005. We enrolled 100 patients with delusional disorder and 50 patients with paranoid schizophrenia as the subject cases, using DSM-IV criteria. We considered equivalent numbers of healthy volunteers matched for age and ethnic background as control subjects. All subjects came from an India-born Bengali population. We applied the polymerase chain reaction–based molecular typing method to all patients and healthy subjects. Results: The HLA-A*03 gene is significantly associated with delusional disorder as well as with paranoid schizophrenia. This HLA gene alone or in linkage disequilibrium with other HLA genes or other closely linked non-HLA genes may influence susceptibility to delusional disorder and paranoid schizophrenia. Conclusions: The study reveals important associations between HLA genes and paranoid disorders. Delusional disorder and paranoid schizophrenia may share similar etiologic mechanisms. This preliminary observation may help our understanding of the genetic basis of these paranoid disorders.
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Fuchs, Christina, Sarita Silveira, Thomas Meindl, et al. "Two Sides of Theory of Mind: Mental State Attribution to Moving Shapes in Paranoid Schizophrenia Is Independent of the Severity of Positive Symptoms." Brain Sciences 14, no. 5 (2024): 461. http://dx.doi.org/10.3390/brainsci14050461.
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Background: Theory of Mind (ToM) impairment has repeatedly been found in paranoid schizophrenia. The current study aims at investigating whether this is related to a deficit in ToM (undermentalizing) or an increased ToM ability to hyperattribute others’ mental states (overmentalizing). Methods: Mental state attribution was examined in 24 patients diagnosed with schizophrenia (12 acute paranoid (APS) and 12 post-acute paranoid (PPS)) with regard to positive symptoms as well as matched healthy persons using a moving shapes paradigm. We used 3-T-functional magnetic resonance imaging (fMRI) to provide insights into the neural underpinnings of ToM due to attributional processes in different states of paranoid schizophrenia. Results: In the condition that makes demands on theory of mind skills (ToM condition), in patients with diagnosed schizophrenia less appropriate mental state descriptions have been used, and they attributed mental states less often to the moving shapes than healthy persons. On a neural level, patients suffering from schizophrenia exhibited within the ToM network hypoactivity in the medial prefrontal cortex (MPFC) and hyperactivity in the temporo-parietal junction (TPJ) as compared to the healthy sample. Conclusions: Our results indicate both undermentalizing and hypoactivity in the MPFC and increased overattribution related to hyperactivity in the TPJ in paranoid schizophrenia, providing new implications for understanding ToM in paranoid schizophrenia.
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Бельская, Ксения Алексеевна, and Сергей Александрович Лытаев. "ELECTROENCEPHALOGRAPHIC ASSESSMENT OF CEREBRAL ACTIVITY NEURODYNAMIC COMPONENTS AND THEIR POSSIBLE ROLE IN THE DEVELOPMENT OF NEUROCOGNITIVE DEFICIENCY." Russian Biomedical Research 9, no. 1 (2024): 24–33. http://dx.doi.org/10.56871/rbr.2024.59.18.004.
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Актуальность работы обусловлена вариабельностью научных представлений о механизмах развития нейрокогнитивного дефицита, ассоциированного с рядом психопатологических состояний. Остается много вопросов о функциях отдельных структур и систем мозга, а также центральной нейродинамики в развитии когнитивного снижения. Наименее изученным в современной нейронауке остается вопрос о влиянии дезорганизации вертикально ориентированных структур I функционального блока мозга (ФБМ) на формирование нейрокогнитивного дефицита при психической патологии шизофренического спектра. Цель исследования заключалась в оценке функционального состояния первого энергетического блока мозга и определении роли нарушений нейродинамических компонентов деятельности в развитии нейрокогнитивного дефицита при психопатологии. Материалы и методы. Обследовано 40 пациентов, страдающих хронической параноидной шизофренией, и 38 здоровых испытуемых, сопоставимых по возрасту, гендерному соотношению и образовательному уровню. Регистрация ЭЭГ осуществлялась монополярно по международной системе 10/20 с помощью 21-канального аппаратно-программного комплекса «Телепат-1». С помощью визуального и спектрального методов анализа изучались как неспецифические физические параметры α-ритма — индекс, частота и амплитуда, так и физиологические особенности α-осцилляций — регулярность, авторитмичность (модуляции) и стабильность α-ритма. Функциональное состояние ретикулярной формации (РФ) определяли по параметрам латентных периодов синхронизации, десинхронизации и глубины десинхронизации в пробе с открытием/закрытием глаз. Тонус коры определяли по соотношению значений индексов альфа- и дельта- ритмов. Порог судорожной готовности мозга рассчитывали по количеству зарегистрированных вспышек в фоновой ЭЭГ. Колебания частоты базового альфа-ритма, превышающие 0,5 Гц, расценивались как признак нестабильности осцилляторной активности мозга. Результаты. Установлено, что нарушения познавательных функций при шизофрении связаны не только с дисфункцией коры (II и III ФБМ), но также с дезорганизацией вертикально ориентированных структур I ФБМ. Выявлена дезорганизация ретикулярной формации и альфа- регулирующей системы, снижение тонуса и активации коры мозга. Обосновано возможное патогенетическое влияние этих патофизиологических факторов на формирование нейрокогнитивного дефицита. Определены наиболее информативные диагностические ЭЭГ-признаки нарушения нейродинамических компонентов деятельности мозга. The relevance of this article is due to the variability of scientific ideas about the mechanisms of development of neurocognitive deficit associated with a line of psychopathological conditions. Many questions remain about the functions of individual brain structures and systems, as well as central neurodynamics in the development of cognitive defects. The question of the influence of the disorganization of vertically oriented structures of the first brain functional block (BFB) on the formation of neurocognitive deficit in mental pathology of the schizophrenic spectrum remains the least studied in modern neuroscience. The present research was aimed to assess the functional state of the first brain energy block and to determine the role of disorders in the neurodynamic components of activity in the development of neurocognitive deficit in psychopathology. Materials and methods. 40 patients with paranoid schizophrenia and 38 healthy subjects matched in age, gender ratio and educational level were examined. EEG by monopolar according to the international system 10/20 using a 21-channel system “Telepat-1” was registered. With the help of visual and spectral methods of analysis, both nonspecific physical parameters of the α-rhythm — index, frequency and amplitude, and physiological features of α-oscillations — reactivity, regularity, autorhythm (modulation) and stability of the α-rhythm were studied. The functional state of the RF was determined by the parameters of the latent periods of synchronization, desynchronization, and the depth of desynchronization in the eye opening/closing test. The tonus of the cortex by the ratio of the values of the indices of alpha- and delta-rhythms was determined. The threshold of convulsive readiness of the brain was calculated from the number of recorded flashes in the background EEG. Fluctuations in the frequency of the basic alpha rhythm exceeding 0.5 Hz were regarded as a sign of instability in the oscillatory activity of the brain. Results. It has been established that impairment of cognitive functions in schizophrenia is associated not only with cortical dysfunction (II and III BFB), but also with disorganization of vertically oriented structures of the I BFB. Revealed disorganization of the reticular formation and alpha-regulating system, decreased tone and activation of the cerebral cortex. The possible pathogenetic influence of these pathophysiological factors on the formation of neurocognitive deficithas been substantiated. The most informative diagnostic EEG-signs of disorders in the neurodynamic components of brain activity were determined.
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Mitrovic, Milica, Milica Ristic, Bojana Dimitrijevic, and Marina Hadzi Pesic. "Facial Emotion Recognition and Persecutory Ideation in Paranoid Schizophrenia." Psychological Reports 123, no. 4 (2019): 1099–116. http://dx.doi.org/10.1177/0033294119849016.
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The recognition of facial signals has a crucial role in social interaction. It is well known that people suffering from paranoid schizophrenia have problems in the social domain, predominantly related to misinterpreting the intentions, emotions, and actions of others. The aim of this study was to examine whether there are differences in facial emotion recognition between people with paranoid schizophrenia and healthy controls. In addition, we examined the correlation between facial emotion recognition and the expression of persecutory ideation in people suffering from paranoid schizophrenia. The study involved 60 participants, 30 of whom suffered from paranoid schizophrenia and 30 healthy controls, equalized by gender, age, and education. The following instruments were used: Japanese and Caucasian Facial Expressions of Emotion and Neutral Faces and the Persecutory Ideation Questionnaire. Compared with the controls, people suffering from paranoid schizophrenia were significantly less accurate in recognizing the following emotions: surprise, contempt, sadness, disgust, and emotionally neutral faces. Since the attribution of emotions to emotionally neutral faces is an important finding that could be linked with the social (dis)functionality of people suffering from paranoid schizophrenia, we analyzed and compared the wrong answers given by the two groups and found some differences between them. The results show that persecutory ideation has a statistically significant negative correlation with the successful recognition of emotionally neutral faces. All of the findings lead to the conclusion that paranoid schizophrenia, and within it the existence of persecutory ideation, leads to problems in recognizing the basic facial signals that form the foundation of everyday social interaction.
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Schoretsanitis, G., A. Kutynia, K. Stegmayer, W. Strik, and S. Walther. "Keep at bay! – Abnormal personal space regulation as marker of paranoia in schizophrenia." European Psychiatry 31 (January 2016): 1–7. http://dx.doi.org/10.1016/j.eurpsy.2015.10.001.
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AbstractBackgroundDuring threat, interpersonal distance is deliberately increased. Personal space regulation is related to amygdala function and altered in schizophrenia, but it remains unknown whether it is particularly associated with paranoid threat.MethodsWe compared performance in two tests on personal space between 64 patients with schizophrenia spectrum disorders and 24 matched controls. Patients were stratified in those with paranoid threat, neutral affect or paranoid experience of power. In the stop-distance paradigm, participants indicated the minimum tolerable interpersonal distance. In the fixed-distance paradigm, they indicated the level of comfort at fixed interpersonal distances.ResultsParanoid threat increased interpersonal distance two-fold in the stop-distance paradigm, and reduced comfort ratings in the fixed-distance paradigm. In contrast, patients experiencing paranoid power had high comfort ratings at any distance. Patients with neutral affect did not differ from controls in the stop-distance paradigm. Differences between groups remained when controlling for gender and positive symptom severity. Among schizophrenia patients, the stop-distance paradigm detected paranoid threat with 93% sensitivity and 83% specificity.ConclusionsPersonal space regulation is not generally altered in schizophrenia. However, state paranoid experience has distinct contributions to personal space regulation. Subjects experiencing current paranoid threat share increased safety-seeking behavior.
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Levine, Joseph, Yoram Barak, and Natan Caspi. "Cognitive Dissonance in the Treatment of Paranoid Schizophrenia." Journal of Cognitive Psychotherapy 9, no. 4 (1995): 267–78. http://dx.doi.org/10.1891/0889-8391.9.4.267.
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Paranoid thinking is often well organized, systemized and detailed so that treating a paranoid patient is a difficult challenge. It is suggested that cognitive dissonance, once created, may cause a person to change his cognitions in order to lower or eliminate it. The treatment of a paranoid schizophrenic is presented wherein by introducing strong group pressure the patient accepted an axiom, which created dissonance with his paranoid content. This axiom was “A wise man sees more than two alternatives in any given situation.” Therefore, by stepwise pacing, alternative evaluations of affect “free” situations were made by the patient using the accepted basic axiom. This technique was gradually used with the patient’s paranoid content, and later on with basic characteristics underlying the paranoid system. The patient exhibited curiosity and a willingness to investigate his paranoid inner state according to the new accepted axiom, and a significant symptomatic relief was seen within a few days, in contrast to past hospitalizations where only partial response to antipsychotic medication was noted. Research is needed in order to examine the effectiveness of this mode of treatment.
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Gangl, Nicole, Frauke Conring, Sebastian Walther, et al. "M13. INCREASED SAFETY SEEKING IN PATIENTS WITH SCHIZOPHRENIA AND PARANOID THREAT." Schizophrenia Bulletin 46, Supplement_1 (2020): S138. http://dx.doi.org/10.1093/schbul/sbaa030.325.
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Abstract Background Schizophrenia is a disabling disorder with tremendous individual burden, reduced quality of life, leading to intense costs for society. Paranoia is a central feature of schizophrenia. In particular, paranoid experience is thought to be associated with aggressive behaviour, and poor social and functional outcome. Since paranoid threat is sometimes hard to detect in the clinical interview, a simple bedside test to identify patients suffering from paranoid experience was recently proposed: the interpersonal distance test. Methods For measuring interpersonal distance in patients with schizophrenia and age-, gender- and education-matched healthy controls, we performed a stop-distance paradigm. To accomplish the paradigm, we positioned experimenter and participant at opposite ends of the room with a distance of seven meters facing each other. The stop-distance paradigm contained four different conditions; two active conditions (i.e. participant is approaching experimenter) and two passive conditions (i.e. experimenter is approaching participant) both, with and without eye contact. Participants were instructed to stop or tell the experimenter to stop at a distance, at which they would start to feel less comfortable. Moreover, we assessed paranoid threat with the Bern Psychopathology Scale. We compared the interpersonal distance between patients with current experiences of paranoid threat, schizophrenic patients without paranoia and healthy controls. Results Patients with higher ratings in paranoid experience presented with higher interpersonal distance than patients without paranoid threat and matched healthy controls. This effect was most prominent in the passive conditions. Patients without paranoia did not differ from healthy controls in the interpersonal distance test. Discussion Interpersonal distance is a reliable indicator of current paranoid threat in patients with schizophrenia. In fact, interpersonal distance is not generally altered in schizophrenia. However, paranoid threat leads to impairments in interpersonal space regulation. This is of particular relevance as interpersonal distance might be predictive of social and functional outcome and aggressive behaviour in schizophrenia.
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Leposavic, Ljubica, Ivana Leposavic, Biljana Saula-Marojevic, and Predrag Gavrilovic. "Paranoid schizophrenia versus schizoaffective disorder: Neuropsychological aspects." Srpski arhiv za celokupno lekarstvo 143, no. 7-8 (2015): 391–96. http://dx.doi.org/10.2298/sarh1508391l.
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Introduction. Neuropsychological aspects of paranoid schizophrenia have still not been examined enough. These disorders are usually not studied separately, but are included in the studies about schizophrenic patients with positive symptoms. Despite the fact that schizophrenia represents a heterogeneous group of mental disorders, usually it is not separated from schizoaffective disorder in neuropsychological researches. Objective. The essence of this research is to evaluate cognitive functioning of patients with paranoid schizophrenia and schizoaffective disorder by applying neuropsychological tests. Methods. The research included 91 subjects, right handed, from 30 to 53 years old, who were classified into three groups: inpatients with paranoid schizophrenia in remission (n=31), inpatients with schizoaffective disorder in remission (n=30) and healthy subjects (n=30). Results. Both groups of patients showed poorer achievements than healthy subjects in most of the applied tests. Patients with schizoaffective disorder showed global loss of intellectual efficiency, executive dysfunction and compromised visual-construction organization. Patients with paranoid schizophrenia expressed partial loss of intellectual efficiency with verbal IQ and executive functions preserved. Conclusion. In the remission phase, patients with paranoid schizophrenia expressed cognitive disorders in moderate degree, but when it comes to patients with schizoaffective disorder, more massive cognitive deficits were registered.
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Aharonovich, E., N. Karny, and I. Nachson. "Visual field processing in paranoid and non-paranoid schizophrenics." European Psychiatry 8, no. 6 (1993): 301–7. http://dx.doi.org/10.1017/s0924933800000687.
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SummaryThe hypothesis that paranoid and non-paranoid schizophrenics are differentially associated with unilateral hemisphere dysfunction was tested on 12 paranoid and 12 non-paranoid schizophrenics, as well as on 24 affective patients and 24 normal controls. The subjects were presented for 150 ms with series of digit-pairs and open rings to the left or right visual fields. Overall recognition of digits and localization of gaps in the rings were better for the right than for the left visual field. However, performance of the paranoid and non-paranoid schizophrenics was relatively poorer in response to the right and left visual field stimuli, respectively. Since these data do not correspond to the findings obtained in the auditory modality, they were interpreted as indicating modality-specific associations of paranoid schizophrenia with left hemisphere dysfunction, and of non-paranoid schizophrenia with right hemisphere dysfunction.
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Canta, Guilherme Rui, Filipe Leão Miranda, Rui Paixão, and Carlos Amaral Dias. "Narcissistic Equilibrium in Paranoid Schizophrenia." Psychodynamic Psychiatry 47, no. 4 (2019): 373–401. http://dx.doi.org/10.1521/pdps.2019.47.4.373.
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Iványi, Pavol, Dagmar Iványi, and Pavel Zemek. "HLA-Cw4 in Paranoid Schizophrenia." Tissue Antigens 9, no. 1 (2008): 41–44. http://dx.doi.org/10.1111/j.1399-0039.1977.tb01078.x.
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Kalian, Moshe, and Eliezer Witztum. "Jerusalem Syndrome or Paranoid Schizophrenia?" Psychiatric Services 51, no. 11 (2000): 1453–54. http://dx.doi.org/10.1176/appi.ps.51.11.1453.
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Fastovsky, Natasha, Alexander Teitelbaum, Josef Zislin, Gregory Katz, and Rimona Durst. "Jerusalem Syndrome or Paranoid Schizophrenia?" Psychiatric Services 51, no. 11 (2000): 1454. http://dx.doi.org/10.1176/appi.ps.51.11.1454.
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Grzywa, A., and H. Karakula. "Depressive Symptoms in Paranoid Schizophrenia." European Psychiatry 12, S2 (1997): 226s. http://dx.doi.org/10.1016/s0924-9338(97)80715-8.
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DiMartini, Andrea, and Robert Twillman. "Organ Transplantation and Paranoid Schizophrenia." Psychosomatics 35, no. 2 (1994): 159–61. http://dx.doi.org/10.1016/s0033-3182(94)71790-4.
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Citak, Serhat, Ebru T. Cakici, Mehmet Cakici, and Samet Kose. "Neuropsychological Assessment in Patients with Paranoid and Non-Paranoid Schizophrenia." Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 23, no. 4 (2013): 294–304. http://dx.doi.org/10.5455/bcp.20131213040431.
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Muna'amah, Rikza Novita, and Elly Yuliandari Gunatirin. "Studi Kasus Karakteristik Kepribadian Pasien Skizofrenia Paranoid Ditinjau dari Minnesota Multiphasic Personality Inventory-2 (MMPI-2)." Insight : Jurnal Pemikiran dan Penelitian Psikologi 16, no. 2 (2020): 201–8. http://dx.doi.org/10.32528/ins.v16i2.3781.
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The personality of paranoid schizophrenia patients is certainly different and has its own peculiarities, therefore, some personality tests are needed so that the diagnosis and application of the intervention can be on target. One of the measuring instruments which widely used is the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). The purpose of this study was to study the personality characteristics of paranoid schizophrenia patients that reviewed with the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). The sampling technique used purposive sampling with one patient. Paranoid schizophrenia has personality characteristics of the type Schizophrenia (Sc) (94 = very high) and Paranoia (Pa) (83 = very high). These patients often have delusions and hallucinations, making it difficult to determine reality and fantasy.
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Muna'amah, Rikza Novita, and Elly Yuliandari Gunatirin. "Studi Kasus Karakteristik Kepribadian Pasien Skizofrenia Paranoid Ditinjau dari Minnesota Multiphasic Personality Inventory-2 (MMPI-2)." Insight : Jurnal Pemikiran dan Penelitian Psikologi 16, no. 2 (2020): 201–8. http://dx.doi.org/10.32528/ins.v16i2.3781.
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The personality of paranoid schizophrenia patients is certainly different and has its own peculiarities, therefore, some personality tests are needed so that the diagnosis and application of the intervention can be on target. One of the measuring instruments which widely used is the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). The purpose of this study was to study the personality characteristics of paranoid schizophrenia patients that reviewed with the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). The sampling technique used purposive sampling with one patient. Paranoid schizophrenia has personality characteristics of the type Schizophrenia (Sc) (94 = very high) and Paranoia (Pa) (83 = very high). These patients often have delusions and hallucinations, making it difficult to determine reality and fantasy.
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Ambekar, Prakash. "Perspective study of disorders of thought, language and communication in schizophrenic patients of Maharashtra." Panacea Journal of Medical Sciences 13, no. 1 (2023): 15–18. http://dx.doi.org/10.18231/j.pjms.2023.004.
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Schizophrenia is a mental disorder characterised by paranoid, hallucination and delirium. The person with such disorder cannot lead a normal life in the society due to his abnormal communication and thought disorder. Hence such disorders are helpful to diagnose the type and severity of disease. Out of 1000 (one thousand) patients 500 were acute schizophrenia and 500 were chronic schizophrenics. Among 1000, 330 were paranoid and 670 were non-paranoid. The disorder of FTD, language, communication disorders in acute, chronic non-paranoid and paranoid schizophrenia were noted. In the comparison of acute and chronic schizophrenic patients – Negative FTD scores positive negative FTD scores, language disorders score was highly significant (p&#60;0.001). In the schizophrenic negative FTD score Negative positive FTD scores, thought disorder score, language disorder scores were highly significant (p&#60;0.001). This study will be helpful to psychiatrist to differentiate acute and chronic schizophrenic patients and treat them efficiently with proper medication so that such patients can lead normal social and family life.
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Sweden, B. Van, M. G. Van Erp, F. Mesotten, and M. Maes. "Frontal cortex reactivity differentiates between schizophrenic subtypes: auditory ERP-evidence." Acta Neuropsychiatrica 13, no. 3 (2001): 61–67. http://dx.doi.org/10.1017/s0924270800035249.
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SUMMARYObjectives: To extend the hypothesis that late auditory EP shifts represent pathophysiologcial markers in schizophrenia. Methods: Early negative (±100 μs) and late positive (>300 ms) auditory oddball and CNV responses are topographically compared in 3 medicated schizophrenic subtypes.Results: Only late cortical responses differentiate between paranoid, residual and disorganised schizophrenia. Core features of the deficit residual state encompass low-voltage N2P3 responses and missing central initial CNV components. Both paranoid and disorganised schizophrenics show a distinctive reactivity of the frontal cortex. Paranoid schizophrenia is characterized by an extensive frontal spread of the task-related P3 response. Disorganised schizophrenia shows a specifically increased frontal CNV component indicating a nonspecific arousal reaction.Conclusion: Combinations of late auditory EP-patterns fairly fit with the cognitive/behavioral status observed in schizophrenia spectrum disorders.
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Pardosi, Sariman. "EFEKTIFITAS TERAPI AKTIVITAS KELOMPOK (TAK) STIMULUS PERSEPSI TERHADAP HALUSINASI PADA PASIEN SKIZOFRENIA PARANOID DI RSJKO SOEPRAPTO BENGKULU TAHUN 2010." JURNAL MEDIA KESEHATAN 5, no. 1 (2018): 33–40. http://dx.doi.org/10.33088/jmk.v5i1.177.
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The most frequent type of schizophrenia is paranoid schizophrenia, whereas in patients with schizophrenia have common criteria and experiencing hallucinations or delusions (Suseno, 2001). Incidence of paranoid schizophrenia in RSJKO Soeprapto Bengkulu in 2008 was (58.84%) and in 2009 was (68.44%) (Medical Record, RSJKO Soeprapto, 2010). Paranoid schizophrenic with hallucinations and panic can act led to the occurrence of suicide or homicide. (Suseno, 2001). Nursing actions appropriate to address a group hallucination is a therapeutic group activities (TAK) (Siahaan HB, 1999). The purpose of research is known influence of group activity therapy (TAK) stimulation perception to hallucinations in RSJKO Soeprapto Bengkulu in 2010.Design research is an experiment: pre and post test. The population was all patients with paranoid schizophrenia who were treated at RSJKO hallucinations Soeprapto Bengkulu, on July 1 to August 31 in 2010, totaling 38 people. Purposive sampling technique with sampling. Analyses were performed by univariate and bivariate frequency distribution with one sample.T test, with α = 5%.The results were: ther’s a relationship bof group activity therapy (TAK) stimulation perception: recognition hallucinations (p = 0.00), controlling hallucinations (p = 0.00), preparation of the schedule of events (p = 0.01), the way drinking either drug (p = 0.00).It is hoped that nurses in RSJKO more intensified activities group activity therapy (TAK) regularly, at least once a week for paranoid schizophrenia patients with hallucinations. In order to speed up eliminating hallucinations and shorten the lengthofthepatient.
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Pardosi, Sariman. "EFEKTIFITAS TERAPI AKTIVITAS KELOMPOK (TAK) STIMULUS PERSEPSI TERHADAP HALUSINASI PADA PASIEN SKIZOFRENIA PARANOID DI RSJKO SOEPRAPTO BENGKULU TAHUN 2010." JURNAL MEDIA KESEHATAN 5, no. 1 (2018): 33–40. http://dx.doi.org/10.33088/jmk.v5i1.177.
Full textAbstract:
The most frequent type of schizophrenia is paranoid schizophrenia, whereas in patients with schizophrenia have common criteria and experiencing hallucinations or delusions (Suseno, 2001). Incidence of paranoid schizophrenia in RSJKO Soeprapto Bengkulu in 2008 was (58.84%) and in 2009 was (68.44%) (Medical Record, RSJKO Soeprapto, 2010). Paranoid schizophrenic with hallucinations and panic can act led to the occurrence of suicide or homicide. (Suseno, 2001). Nursing actions appropriate to address a group hallucination is a therapeutic group activities (TAK) (Siahaan HB, 1999). The purpose of research is known influence of group activity therapy (TAK) stimulation perception to hallucinations in RSJKO Soeprapto Bengkulu in 2010.Design research is an experiment: pre and post test. The population was all patients with paranoid schizophrenia who were treated at RSJKO hallucinations Soeprapto Bengkulu, on July 1 to August 31 in 2010, totaling 38 people. Purposive sampling technique with sampling. Analyses were performed by univariate and bivariate frequency distribution with one sample.T test, with α = 5%.The results were: ther’s a relationship bof group activity therapy (TAK) stimulation perception: recognition hallucinations (p = 0.00), controlling hallucinations (p = 0.00), preparation of the schedule of events (p = 0.01), the way drinking either drug (p = 0.00).It is hoped that nurses in RSJKO more intensified activities group activity therapy (TAK) regularly, at least once a week for paranoid schizophrenia patients with hallucinations. In order to speed up eliminating hallucinations and shorten the lengthofthepatient.
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Hutagaol, Sartika, Putu Rika Veriyanti, Jerry Jerry, et al. "A Gambaran Pola Penggunaan Obat Antipsikotik Kombinasi Pada Pasien Skizofrenia Paranoid Rawat Jalan di Rumah Sakit Jiwa Dr. Soeharto Heerdjan." Jurnal Kesehatan Masa Depan 2, no. 2 (2023): 113–37. https://doi.org/10.58516/tfwdm962.
Full textAbstract:
Overview Of The Pattern Of Use Of Combination Antipsychotics Drugs In Outpatient Paranoid Schizophrenia At Dr. Soeharto Heerdjan Hospital Abstract Schizophrenia is a severe mental disorder characterized by impaired reality values in the form of hallucinations and delusions. This study aims to determine the pattern of use of combination antipsychotic drugs in outpatients with paranoid schizophrenia at Dr. Mental Hospital. Suharto Heerdjan. This study is descriptive and data collection is retrospective and the sample data obtained are 109 patients. The results showed that the most paranoid schizophrenic patients in the 35-44 year age group were 51 patients (46.79%), 80 patients (73.40%) were male, 42 patients (38.53%) had high school education, not working as many as 89 patients (81.65%), unmarried as many as 88 patients (80.73%), long suffering 1-5 years as many as 57 patients (52.30%), without complaints, calm and cooperative as many as 94 patients (86.24%). The most widely used group of drugs was atypical – atypical combination antipsychotic drugs as many as 66 patients (51.36%). The most widely used therapy was the combination of risperidone + clozapine (54.54%). The use of antipsychotic drugs in outpatient paranoid schizophrenia patients at the Dr. Soeharto Heerdjan Hospital had the right indication, the right drug, the rightdose and frequency of the drug, the right route of administration, the right time administration and alert for side effects. Keywords: Antipsychotics; paranoid schizophrenia; drug use pattern
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Nisaa’, Chairun, Fitriatul Masruroh, and Herlan Pratikto. "EXPRESSIVE WRITING THERAPY UNTUK MENINGKATKAN KEMAMPUAN PENGUNGKAPAN DIRI (SELF DISCLOSURE) PADA PASIEN SKIZOFRENIA PARANOID." Ar-Risalah Media Keislaman Pendidikan dan Hukum Islam 20, no. 1 (2022): 195. http://dx.doi.org/10.69552/ar-risalah.v20i1.1341.
Full textAbstract:
Schizophrenia is a psychotic disorder characterized by major disturbances in the mind, emotions, and disturbed mind-behavior. Schizophrenia disorder is divided into 3 types, namely disorganized, catatonic and paranoid schizophrenia. The main feature of paranoid type schizophrenia is the focus on one or more delusions that include greatness, persecution, jealousy, anxiety, or confusion in the absence of evidence. The focus of this study is the provision of interventions in the form of expressive writing therapy to improve self-disclosure to one of the paranoid schizophrenia patients at RSJ Menur Surabaya. The study was conducted for 5 weeks with details of 3 weeks of psychological assessment and 2 weeks of psychological intervention. The methods used in research are qualitative with a case study approach. The results of this study indicate that expressive writing therapy is effectively used as a medium to express the feelings/emotions of the Subject.
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Rivera, Carmen Senra, Alexandra De Arriba Rossetto, Gloria Seoane Pesqueira, and M. José Eerraces Otero. "Attitudes of University Students towards People with Paranoid Schizophrenia." Psychological Reports 100, no. 1 (2007): 325–32. http://dx.doi.org/10.2466/pr0.100.1.325-332.
Full textAbstract:
To study attitudes towards persons with paranoid schizophrenia of first- and final-year university students taking three different majors, Link's Social Distance Scale, modified to relate to several vignettes presenting different descriptions of a patient with paranoid schizophrenia, was administered to 617 university students ages 18 to 29 years ( M = 21.1, SD = 2.6). 423 were women and 194 men. Analysis indicates fourth year psychology majors reported the greatest acceptance of persons with paranoid schizophrenia. The most efficient vignette in diminishing rejection of the portrayed patient included information on the patient's psychosocial rehabilitation status. University students' attitudes appear to vary with the training they receive and the kind of information they have about the patient.
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Stein, Murray B., and A. R. Siddiqui. "Acute Paranoid Disorder and Klinefelter's Syndrome." Canadian Journal of Psychiatry 31, no. 5 (1986): 434–35. http://dx.doi.org/10.1177/070674378603100510.
Full textAbstract:
A twenty-five-year old man presented with an acute paranoid disorder, and was subsequently diagnosed as having Klinefelter's Syndrome. Our review of previous reports suggests that the literature pointing out a particular association between Klinefelter's and schizophrenia may be misleading. In fact, Klinefelter's patients are liable to suffer from schizophrenia, paranoid disorders, or possibly other disorders.
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Mazumdar, P. K., S. K. Chaturvedi, and P. S. Gopinath. "A Study of Thought Disorder in Paranoid and Non-Paranoid Schizophrenia." Psychopathology 24, no. 3 (1991): 166–69. http://dx.doi.org/10.1159/000284710.
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