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Dissertations / Theses on the topic 'Defects of development'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Ching, Yung-Hao. "Molecular genetics of human atrial septal defects." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246413.

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2

Courtney, Jennifer A. "The Role of Abnormal Placentation in Congenital Heart Defects." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1623165569297281.

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3

Zhou, Shuangcheng, and 周雙宬. "Defects in early B lymphocyte development in Zmpste24⁻′⁻ mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43703641.

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4

Stephens, Clare Jean. "Development of gene therapy for the treatment of inherited retinal degeneration." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246906.

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5

Shum, Alisa Sau Wun. "The development of neural tube defects in the mouse embryo." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306186.

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6

Al-Bagdady, Mohammad. "Visual development and visual defects in children with Down's syndrome." Thesis, Cardiff University, 2009. http://orca.cf.ac.uk/54944/.

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This thesis investigated the refractive, accommodative and colour vision status of young people with Down's syndrome (DS). Seven separate studies were conducted. Participants were recruited from the Cardiff Down's Syndrome Vision Research Unit. Abnormal refractive development was reported from an early age, and continued through the first 15 years of life. The normal emmetropisation process was re-aligned to leave subjects with hypermetropic errors, with a wide variation in refractive error, at all ages. There was a specific development of oblique astigmatism with age, which may be associated

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7

Marshman, Zoe. "The impact of development defects of enamel on young people." Thesis, University of Sheffield, 2007. http://etheses.whiterose.ac.uk/6099/.

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Background: in order to ascertain whether Developmental Defects of Enamel (DDE) constitute a public health problem it is necessary to consider whether the condition impacts on the lives of affected individuals. Aim: to describe the impact of DDE on individual young people. Objectives: 1) Describe the extent to which contemporary dental research on DDE has included the perspective of children and young people. 2) Describe the impact of DDE on the oral health-related quality of life (OHRQoL) of young people. 3) Explore, in detail, the impact of DDE on young people. Methods: a systematic review o

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8

Zhou, Shuangcheng. "Defects in early B lymphocyte development in Zmpste24⁻?p- mice." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43703641.

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9

Limperopoulos, Catherine. "Neurobehavioral status of newborns with congenital heart defects." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29743.pdf.

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10

Afridi, Asad Hameed. "Development of Microwave sensor and Android Application for monitoringlong bone defects." Thesis, Uppsala universitet, Institutionen för informationsteknologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-348878.

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Fractures of the long bones are one of the most common injuries. Long bone are always at risk for fractures and require careful treatment to avoid the human disabilities. Microwave technology is using to development of biomedical sensors for detecting and monitoring bone defects. Microwave are electromagnetic (EM) radiation with frequencies between 300MHz and 300 GHz. The microwave technology is used in wireless networking and communication systems, wireless security systems, remote sensing and medical application. The main purpose of this thesis is to investigate rectangular microstrip patch

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11

Thomas, Howard LaVann. "Analysis of defects in woven fabrics : development of the knowledge base." Thesis, Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/9185.

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12

White, Christopher Ben. "Investigation of mitochondrial DNA defects in the development of diabetes mellitus." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417499.

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13

Fleming, Angeleen Louise. "Development and prevention of neural tube defects in the mouse embryo." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287550.

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14

Phaphoom, Nattakarn. "Pair Programming and Software Defects : A Case Study." Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-3513.

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Pair programming is a programming technique in which two programmers sit literally side by side working on the same task at the same computer. One member of a pair called “driver” is in charge of writing the code. The other member plays a role of “navigator”, working on the more strategic tasks, such as looking for tactical error, thinking about overall structure, and finding better alternatives. Pair programming is claimed to improve product quality, reduce defects, and shorten time to market. On the other hand, it has been criticized on cost efficiency. To increase a body of evidence regardi

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15

Sushko, Petr Valentinovich. "Development and application of embedded cluster methodologies for defects in ionic materials." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326037.

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16

Wilson, John Barry. "Colour vision defects : the development of computer-generated test for their diagnosis." Thesis, University of York, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265365.

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17

Xu, Jiadi. "DNA repair defects as a mechanism contributing to the development of lupus." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367938177.

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18

Blomberger, Daniela. "Development of a novel Voronoi structured scaffold for critical-size bone defects." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/206168/1/Daniela_Blomberger_Thesis.pdf.

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Over the last decade, technological development has led to a revolution in the treatment of bone injuries. Few technologies hold more promise than 3D printing of biological material, which includes the field of bone science. This dissertation focused on 3D printed biodegradable scaffolds by using a novel Voronoy structured scaffold for critical-size bone defects that follows the definitions defined by mathematician Georgy Voronoy. These offer innovative healing opportunities for patients experiencing large bone defects, induced either by accidental or pathological causes, to regenerate the dam

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19

Medeiros, Guilherme Cardoso. "Development of a test methodology for FinFET-Based SRAMs." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2017. http://tede2.pucrs.br/tede2/handle/tede/7647.

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Submitted by Caroline Xavier (caroline.xavier@pucrs.br) on 2017-09-11T13:09:26Z No. of bitstreams: 1 DIS_GUILHERME_CARDOSO_MEDEIROS_COMPLETO.pdf: 10767866 bytes, checksum: f8ce0a0593916dec149c9417c21ff36e (MD5)<br>Made available in DSpace on 2017-09-11T13:09:26Z (GMT). No. of bitstreams: 1 DIS_GUILHERME_CARDOSO_MEDEIROS_COMPLETO.pdf: 10767866 bytes, checksum: f8ce0a0593916dec149c9417c21ff36e (MD5) Previous issue date: 2017-08-17<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES<br>Miniaturiza??o tem sido adotada como o principal objetivo da ind?stria de Circuitos Integr

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20

Hynds, Ernest Jefferson. "The development and testing of a balloon catheter to occlude ventrical septal defects." Thesis, Georgia Institute of Technology, 1988. http://hdl.handle.net/1853/16081.

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21

Clowes, Christopher. "Investigation of genetic and developmental defects in the L11Jus8 mutant mouse." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-genetic-and-developmental-defects-in-the-l11jus8-mutant-mouse(07060731-7766-4f23-9477-f11090248030).html.

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Mutagenesis screening in mice is an effective means of identifying essential genes in cardiovascular development. The l11Jus8 (L8) mutant mouse line was originally isolated from a region-specific N-ethyl-N-nitrosourea (ENU) chemical mutagenesis screen and exhibited an autosomal recessive mid-gestational embryonic lethal phenotype characterised by haemorrhage in the thoracic cavity, blood pooling in the heart, right ventricular dysmorphology and yolk sac vascular degeneration. Prior work mapped the L8 mutation to a ~2.77Mb region on mouse chromosome 11. The aim of this study was to further char

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22

Frame, Dustin Michael. "Microstructural development and the evolution of defects in constrained and sinter-forged ceramics /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/10607.

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23

Li, Yuan. "IL10 mRNA stability defects as a mechanism contributing to the development of lupus." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439310501.

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24

Al, Owaisi S. S. "Development of an improved structural integrity assessment methodology for pressurised pipes containing defects." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/35953/.

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Metal loss due to corrosion is a serious threat to the integrity of pressurised oil and gas transmission pipes. Pipe metal loss defects are found in either single form or in groups (clusters). One of the critical situations arises when two or more defects are spaced close enough to act as a single lengthier defect, causing major impact on the pressure containing capacity of a pipe and leading to rupture rather than localised leak at the centre of defects. There have been many studies conducted to determine the distance needed for defects to interact leading to a failure pressure lower than tha

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25

Lambers, Rebeca. "Development of a model to risk manage construction defects in the residential sector." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/134079/2/Rebeca_Lambers_Thesis%5B1%5D.pdf.

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This research unfolds the frequently occurring defects in the residential construction sector and examines those key defects in depth. In particular, the research extends existing knowledge about defects causation and management and assesses the practical barriers and nature of trade work in Queensland residential construction. Findings of this research suggest that key risk management strategies and causes for defects are specific to each construction trade and only a few risk-management strategies can be administered through all the residential trades. This study provides building profession

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26

Moodi, Faramarz. "Development of a knowledge-based system for the repair and maintenance of concrete structures." Thesis, University of Newcastle Upon Tyne, 2001. http://hdl.handle.net/10443/481.

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Information Technology (IT) can exploit strategic opportunities for new ways of facilitating information and data exchange and the exchange of expert and specialist opinions in any field of engineering. Knowledge-Based Systems are sophisticated computer programs which store expert knowledge on specific subject and are applied to a broad range of engineering problems. Integrated Database applications have facilitated the essential capability of storing data to overcome an increasing information malaise. Integrating these areas of Information Technology (IT) can be used to bring a group of exper

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27

Chan, Jessica See Wen 1984. "The role of 5,10-methylenetetrahydrofolate reductase and nutritional deficiencies in cardiac development /." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111553.

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Disruptions in folate metabolism are known to increase the risk for neural tube defects (NTD) and this is preventable by folic acid supplementation. However, the relationship between folate metabolism and cardiac development remains unclear. The interaction between other folate pathway nutrients, choline and riboflavin, and folate metabolism was studied in a murine model of methylenetetrahydrofolate reductase (MTHFR) deficiency. Maternal choline deficiency, riboflavin deficiency and MTHFR deficiency adversely affected embryonic or heart development. The promoters of MTHFR were also examined fo

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28

Al, Deiri Mhd Bashar. "TGF-B signalling in the development of ventral embryonic structures." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/tgfb-signalling-in-the-development-of-ventral-embryonic-structures(7a337628-d26d-436b-b18c-62619bbbf130).html.

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Ventral body wall closure (VBW) defects are amongst the most common human congenital anomalies. They represent a wide and heterogeneous group of phenotypic defects that can present in isolation or as a component in a larger syndromic anomaly. In addition, the incidence of associated anomalies is high and reaches 75% of fetuses in some types of VBW closure defects. Nevertheless, the embryonic origin and the underlying cellular and molecular mechanisms between ventral closure defects and their associated congenital anomalies remain poorly characterised. This is in part due to the poor understand

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29

von, Oldenburg Tim. "Making scope explorable in Software Development Environments to reduce defects and support program understanding." Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24006.

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Programming language tools help software developers to understand a program and to recognize possible pitfalls. Used with the right knowledge, they can be instrumented to achieve better software quality. However, creating language tools that integrate well into the development environment and workflow is challenging.This thesis utilizes a user-centered design process to identify the needs of professional developers through in-depth interviews, address those needs through a concept, and finally implement and evaluate the concept. Taking 'scope' as an exemplary source of misconceptions in progra

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30

PENNA, SARA. "Development of novel cell based therapeutic approaches to correct primary and secondary bone defects." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/304794.

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Le malattie scheletriche pediatriche compromettono fortemente la durata della vita. Disturbi monogenici rari e gravi come l'osteopetrosi autosomica recessiva (ARO) e la mucopolisaccaridosi di tipo 1 Hurler (MPSIH) sono causati rispettivamente da difetti ossei primari e secondari. In particolare, i pazienti con ARO soffrono di elevata densità e fragilità ossea, difetti neurologici e fibrosi del midollo osseo che portano ad un aumento del numero di cellule CD34+ circolanti. La forma più frequente di ARO è dovuta alle mutazioni del gene TCIRG1, che codifica per una pompa protonica necessaria per

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31

Popova, Milena Kamenova. "Rb deficiency during Drosophila melanogaster eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110536.

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Retinoblastoma, Rb, tumor suppressor protein is a cell cycle regulator preventing transition from G1 to S phase. Rb also regulates various biological processes during development and tumorigenesis. While the molecular mechanism by which pRb controls cell cycle progression is well characterized, how pRb promotes cell-type specification and differentiation is less understood. A genetic overexpression screen searching for factors cooperating with mutations in rbf1, the Drosophila homologue of Rb, lead to the identification of emc, extramacrochaetae, whose mammalian homologue Id2 has a known role

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32

Cooney, Laura Gilbert Hollingsworth. "A Role for Cilia in Endocardial Cushion Development." Yale University, 2010. http://ymtdl.med.yale.edu/theses/available/etd-03052010-091456/.

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Congenital heart defects due to the aberrant development of the atrioventricular (AV) valves and septum are among the most common developmental abnormality in newborns and cause significant neonatal morbidity and mortality. A key point in cardiac morphogenesis occurs when cells within the endocardial cushions (ECCs), the precursors for the AV valvoseptal complex, delaminate and undergo an epithelial-to-mesenchymal transformation (EMT). The mesenchymal cells then proliferate and the cushion area elongates to form the AV valves and portions of the AV septae. The signals that initiate region-spec

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33

Müller, Laura Mara. "Study of novel molecular defects in human pancreas dysfunction." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22597.

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Diabetes ist ein weltweites Problem, das durch den Verlust oder die Dysfunktion der Insulin-produzierenden β-Zellen des Pankreas verursacht wird. In seltenen Fällen entsteht Diabetes durch eine Mutation in einem einzigen Gen. Diese monogenetischen Formen des Diabetes können zur Identifizierung neuer Regulatoren der β-Zellen-Entwicklung und -Funktion beitragen. In der vorliegenden Arbeit habe ich neue putative Diabetes-assoziierte Gene untersucht, die zuvor durch „Next-Generation“ Sequenzierung in einer Gruppe von Kindern und Jugendlichen mit idiopathischem Diabetes festgestellt wurden. Insbe

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34

Garitezi, Thales Macedo 1987. "Magnetismo e supercondutividade em novos compostos intermetálicos à base de FeAs." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/278545.

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Orientadores: Pascoal José Giglio Pagliuso, Oscar Ferreira de Lima<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Física Gleb Wataghin<br>Made available in DSpace on 2018-08-17T19:19:42Z (GMT). No. of bitstreams: 1 Garitezi_ThalesMacedo_M.pdf: 5487109 bytes, checksum: 11408acef0a6ff80a1788db976f23149 (MD5) Previous issue date: 2011<br>Resumo: Os supercondutores à base de ferro e arsênico foram descobertos em 2008, primeiramente na forma de um óxido LaFeAsO1-xFx com uma temperatura crítica de 26 K, e poucos meses depois na forma do intermetálico livre de oxigênio

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35

Coleman, Rhima M. "Development of a small animal model to study tissue engineering strategies for growth plate defects." Diss., Available online, Georgia Institute of Technology, 2007, 2007. http://etd.gatech.edu/theses/available/etd-07092007-093731/.

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Thesis (Ph. D.)--Bioengineering, Georgia Institute of Technology, 2008.<br>Guldberg, Robert, Committee Chair ; Boyan, Barbara, Committee Member ; O'Keefe, Regis, Committee Member ; Vito, Ray, Committee Member ; Bellankonda, Ravi, Committee Member.

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36

Marshall, David. "The development and use of trichromatic mixture thresholds for the study of color vision defects /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487780393267809.

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37

Li, Xiao. "The molecular mechanisms of PITX2 in tooth development and enamel defects in Axenfeld-Rieger Syndrome." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/5014.

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Patients with Axenfeld-Rieger Syndrome (ARS) present various dental abnormalities. ARS is genetically associated with mutations in the PITX2 gene, which encodes one of the earliest transcription factors to initiate tooth development. Thus, Pitx2 has long been considered as an upstream regulator of the transcriptional hierarchy in tooth development. However, it is unclear how its mutant forms cause ARS dental anomalies. In this report, we outline the transcriptional mechanism that is defective in ARS. We demonstrate that during normal tooth development Pitx2 activates Amelogenin (Amel) expr

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38

Duong, Tiffany. "Mechanisms of NR2Fs in Heart Valve Development." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505149242216719.

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39

Hosako, Hiromi. "The role of p53 in normal development and teratogen-induced apoptosis and birth defects in mouse embryos." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3251.

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40

Randolph, Tyler W. "Development of automated method of optimizing strength of signal received by laser interferometer." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29686.

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Thesis (M. S.)--Mechanical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Ume, I. Charles; Committee Member: Mayor, J. Rhett; Committee Member: Sadegh, Nader. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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41

Dixon, Michael James. "Growth factor (EGF and TGF #propor to#) involvement in mouse palatal development with particular reference to the signalling of epithelial-mesenchymal interactions." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328364.

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42

Restrepo, Pelaez Maria. "Development of a coupled geometrical multiscale solver and application to single ventricle surgical planning." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54832.

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Single ventricle heart defects are present in two of every 1000 live births in the US. In this condition the systemic and pulmonary blood flow mix in the functioning ventricle, resulting in insufficient blood oxygenation to sustain life. As part of the palliation of these defects, the staged surgical procedure, known as the Fontan procedure, is performed. Here, the venous returns are directed to the pulmonary arteries, bypassing the right heart and forming the Total Cavopulmonary Connection (TCPC). Even though the palliation improves life expectancy, there are numerous long-term complications

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43

Weselak, Mandy. "Pregnancy pesticide exposures, birth defects and child health outcomes in the Ontario Farm Family Health Study." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26806.

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The use of pesticides has served to enhance the economies and health of nations around the world by amplifying crop production and reducing crop loss. At the same time, studies have linked pre- and post-natal pesticide exposures to certain childhood cancers, neurological deficits, and adverse pregnancy outcomes. We explored the relationship between parental pesticide exposure during the pre-conception (3 months prior to conception) and post-conception (first trimester, entire pregnancy period) periods on specific child health outcomes. Our results suggest that pre-conception exposure to cyanaz

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44

Mangoli, Maryam. "Molecular and phenotypic characterisation of zebrafish mutants displaying defects in axonal development in the central nervius system." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408677.

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45

Perez, Blanco Isabel Cristina [Verfasser]. "A model development for reconstruction of three-dimensional defects based on MFL signals / Isabel Cristina Perez Blanco." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1224883586/34.

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46

Sinclair, Hugo Graeme. "Development of 3D-STED microscopy and its application to luminescent defects in diamond, nanoparticles and biological samples." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/28235.

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The work presented in this thesis follows two main branches. The first aims to develop instrumentation for 3D-STED microscopy and to apply it to the study of bulk diamond, nanoparticles and biological samples. The second aims to evaluate the application of fluorescence imaging and spectroscopy techniques to the study of luminescent defects in diamond. Building on previous work in the Photonics Group at Imperial College London, spatial light modulator (SLM) technology was incorporated into a STED system in a novel configuration to provide a robust and convenient solution for 3D-STED microscopy.

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47

Rawool, Shubham Shivaji. "Development of methodology for detection of defect locations in pavement profile." Thesis, Texas A&M University, 2003. http://hdl.handle.net/1969.1/2440.

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Pavement smoothness has become a standard measure of pavement quality. Transportation agencies strive to build and maintain smoother pavements. Smooth roads provide comfort while riding, minimize vehicular wear and tear and increase pavement life. A user perceives smoothness of a pavement based on the ride quality, which is severely affected by presence of defects on pavement surface. Defects identified after construction are corrected as per smoothness specifications prescribed by respective transportation agencies. The effectiveness of any method used to determine defect locations depends on

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48

Tailony, Rauf. "Internal Combustion Engine Cold Test Driveline Modeling, Analysis and Development." University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1564765172535669.

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49

Brockmeier, Peter Macy. "Surgical Navigation for Articular Cartilage Repair: Motivation, Development, and Validation." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1250219405.

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50

Zareie, Rajani Hamid Reza. "Development of a three-dimensional multi-scale model to study the formation of solidification defects in fusion welding." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57601.

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One of the long-standing challenges in joining of aluminum alloys is the occurrence of solidification defects, i.e. hot cracking and porosity, since these defects significantly increase manufacturing costs. This research project investigates the formation of solidification defects through development of a novel and comprehensive 3-D multi-scale and multi-physics numerical study and then application to the GTA welding of the aluminum alloy AA6061. The developed multi-scale model is composed of four different modules: 1) Solidification, 2) Deformation, 3) Fluid flow, and 4) Defect formation. Th

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