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Dissertations / Theses on the topic 'Defence mechanism'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Gautrey, Charlotte. "The biomechanics of the dynamic defence mechanism." Thesis, University of Hertfordshire, 2013. http://hdl.handle.net/2299/13905.

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Context: It has been suggested that muscle fatigue can lead to injury, however, research investigating this phenomenon in functional ankle instability (FAI) subjects is lacking. Aim: The purpose of this thesis was to research postural sway and muscular latency in FAI subjects and healthy controls, both before and immediately after localised and globalised fatigue protocols. Subjects: All subjects used in this project were males, between the ages of 18 and 25 years, and participated in regular (>2 x week) aerobic exercise. Subjects were categorised into healthy subjects, or subjects with a h

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2

Van, Dyk Johannes Jacobus. "An evaluation of the South African Department of Defence's policy on Defence Industrial Participation (DIP) as a defence industrial development mechanism." Thesis, Nelson Mandela Metropolitan University, 2008. http://hdl.handle.net/10948/1067.

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This dissertation focuses on the local defence-related industry as a beneficiary under the Department of Defence’s defence industrial participation (DIP) programme, managed by Armscor. Attention is given to the main construct of the development theory and how the DIP process in South Africa compares with the international reciprocal trade phenomena commonly referred to as ‘countertrade’. The author does an in-depth analysis of the Government’s policy regarding the defence-related industry (DRI) that forms part of the local defence industrial base (DIB), as well as the DIP policy, procedures an

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3

Stiff, Harald. "Explainable AI as a Defence Mechanism for Adversarial Examples." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-260347.

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Deep learning is the gold standard for image classification tasks. With its introduction came many impressive improvements in computer vision outperforming all of the earlier machine learning models. However, in contrast to the success it has been shown that deep neural networks are easily fooled by adversarial examples, data that have been modified slightly to cause the neural networks to make incorrect classifications. This significant disadvantage has caused an increased doubt in neural networks and it has been questioned whether or not they are safe to use in practice. In this thesis we pr

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4

Alobaidi, H. M. M. "Host defence mechanism in CAPD : a laboratory and clinical investigation." Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356679.

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5

Arranz, Trullén Javier. "Unveiling the multifaceted antimicrobial mechanism of action of human host defence RNases." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400666.

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La presente tesis doctoral se encuentra integrada dentro del estudio a gran escala de la estructura-función de las ribonucleasas antimicrobianas humanas. Estas proteínas catiónicas y de bajo peso molecular son secretadas por la mayoría de los organismos vertebrados agrupándose dentro la superfamilia de la ribonucleasa A, una de las enzimas mejor caracterizadas del siglo XX. De interés remarcable podríamos considerar su amplio abanico de propiedades biológicas, teniendo en cuenta su diverso historial de propiedades biológicas no catalíticas, convirtiéndolas en un buen modelo de proteínas

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6

Hammami, Aida, and Pernilla Spåls. "Consequences of being a stress resilient child." Thesis, Högskolan i Gävle, Avdelningen för socialt arbete och psykologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-10790.

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Aim; The aim of this study is to increase our knowledge of stress resilience children coming from backgrounds of substance abuse and to look at what consequences they may encounter, for not being able to express their emotions and deal with happenings experienced in their upbringing. Method; A qualitative approach has been used with e-mail interviews to collect our material, with young adults whom see themselves as having a history of alcoholism in the nearest family when growing up and despite this managed well in life. Result: We have concluded that resiliency is a way of coping with stress

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7

Walter, J. B. "Studies on the nodule formation as a cellular defence mechanism in some insect species." Thesis, Swansea University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639333.

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8

Bates, Chad. "The mechanism of defence : identity, structure and perceptions of gender and sexuality in the military." Thesis, University of Liverpool, 2011. http://livrepository.liverpool.ac.uk/5673/.

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The 'Mechanism of Defence' project is an interdisciplinary study that examines the effect of sexuality on the perceived cohesion, morale and unit effectiveness of University Officer Training Corps (UOTC) battalions. The study privileges sociological theory and social policy using Emile Durkheim’s Division of Labour as its primary theoretical frame. The study evidences the influence of social structure as a central and abiding force in the establishment of community values and the integration of sexual minorities. It seeks to inform integrative measures in countries like the United States by ex

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9

Balakrishnan, Kogila. "Evaluating the effectiveness of offsets as a mechanism for promoting Malaysian defence industrial and technological development." Thesis, Cranfield University, 2008. http://dspace.lib.cranfield.ac.uk/handle/1826/2504.

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Offsets have taken centre stage in defence trade. To date, more than 78 countries around the world practice offsets and outstanding offsets obligations run into billions of US dollars However, why have offsets gained such a momentum? Increasingly, both sellers and buyers in the arms trade view offsets as an efficient and effective economic compensation tool to justify arms deals. Buyers, consider offsets as a catalyst for industrial and technological development, employment, creation of value-added activities and skills development. Sellers, on the other hand, perceive offsets as providing pro

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10

Eichinger, Tobias Michael. "European Integration in Defence. Examining the Development of CSDP after Brexit through a Mechanism-Based Approach." Thesis, Stockholms universitet, Institutionen för ekonomisk historia och internationella relationer, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-193785.

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11

Balakrishnan, K. "Evaluating the Effectiveness of Offsets as a Mechanism for Promoting Malaysian Defence Industrial and Technological Development." Thesis, Cranfield University, 2008. http://hdl.handle.net/1826/2504.

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Offsets have taken centre stage in defence trade. To date, more than 78 countries around the world practice offsets and outstanding offsets obligations run into billions of US dollars However, why have offsets gained such a momentum? Increasingly, both sellers and buyers in the arms trade view offsets as an efficient and effective economic compensation tool to justify arms deals. Buyers, consider offsets as a catalyst for industrial and technological development, employment, creation of value-added activities and skills development. Sellers, on the other hand, perceive offsets as providing pro

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12

Salazar, Montoya Vivian Angélica. "Exploring the mechanism of action of human antimicrobial ribonucleases." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/310611.

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Las ribonucleases humanas son un grupo heterogéneo de proteínas pertenecientes a la superfamilia de la Ribonucleasa A. Estas proteínas se caracterizan por su capacidad de hidrolizar ácidos ribonucleicos y por la presencia de actividad antimicrobiana frente diversos organismos patógenos como bacterias, hongos, parásitos y virus. El primer objetivo del presente estudio doctoral se centra en la caracterización de la actividad antimicrobiana y en modelos de membrana de las formas nativas de la ribonucleasa 3 purificadas a partir de eosinófilos. Las distintas formas nativas presentan modific

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13

Drago-Toscano, Claudia. "Variation in defence mechanism activities in Sitka spruce (Picea Sitchensis (Bong.) Carr.) and its relation to disease resistance and susceptibility." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329961.

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14

Fite, Alemu. "The antimicrobial interaction of acidified nitrite with other physiologically active compounds (PAC), the potential host defence mechanism of dietary nitrate." Thesis, University of Aberdeen, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369736.

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Transfer of nitrite at salivary concentrations enhance the antimicrobial activity of stomach acid against food borne pathogens and may be involved in the host defence of humans and animals. Studies from experimental animals, microbial tests, human <I>ex vivo</I> and <I>in vivo</I> investigations support the hypothesis that dietary nitrate is beneficial for health. The positive findings that acidified nitrite is antimicrobial at the acidic conditions of the stomach is viewed in conjunction with the potential production of nitrogen, intermediates such as NO, a molecule of significant importance

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15

Salander, Pär. "Qualities in the short life : psychological studies relevant to patient and spouse in malignant glioma." Doctoral thesis, Umeå universitet, Onkologi, 1996. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96905.

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This thesis deals with psychological issues concerning patients with malignant gliomas, and their spouses. There is no known medical cure, and the patients have a limited survival expectancy. Therefore studies evaluating new treatment modes, an overall supportive atmosphere, and attempts to avoid imposing unnessesary strain are necessary. Thirty consecutive patients with astrocytomas, grade III-IV, were included in a clinical trial with estramustine phosphate in addition to conventional treatment with surgery and radiotherapy. Both the patients and their spouses participated in the present stu

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16

Al-Shakarchi, N. H. A. "#Alpha#-precipitin of the Atlantic salmon (Salmo salar) during an outbrwak of ulcerative dermal necrosis and its possible role in the defence mechanism of the animal." Thesis, University of Salford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376858.

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17

Du, Plessis Amanda Linda. "Die begeleiding van die gedissosieerde persoon tot geestelike en emosionele groei : 'n pastorale studie / Amanda L. du Plessis." Thesis, North-West University, 2005. http://hdl.handle.net/10394/123.

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Because of the inability to deal with traumatic and stressful situations it often happens that a person dissociates. These people then 'move out of the situation', so to speak. The dissociated person can be spiritually, emotionally and physically handicapped for life. In the long term it often results in depression, feelings of guilt, relationship problems, social maladjustment, as well as addiction to medication. Pastoral counselling to this person (as part of a multidisciplinary approach) often results in a decline of the symptoms and a normalisation of the person's situation. From the basis

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18

Fransson, Per. "Defense mechanism test och ungdomar." Doctoral thesis, Umeå universitet, Institutionen för psykologi, 1998. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-96882.

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19

Traylor, Pamina. "Defense mechanisms /." Online version of thesis, 1995. http://hdl.handle.net/1850/12151.

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20

Burrells, C. "Studies on ovine pulmonary defence mechanisms." Thesis, Edinburgh Napier University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355318.

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21

Hsieh, Ji-Fan (Sarah). "Molecular and Chemical Mechanisms of Defence against Myrtle Rust in Australian Myrtaceae." Phd thesis, Canberra, ACT : The Australian National University, 2018. http://hdl.handle.net/1885/143530.

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Increased human disturbance to forest ecosystems has exacerbated the spread of fungal pathogens to non-native environments. Rust pathogens (Pucciniales) can spread long distances by human activity and wind dispersal, and can cause severe disease outbreaks in cereal crops and in forest trees. The exotic fungus Austropuccinia psidii (myrtle rust) arrived in Australia in 2010 and most species of native Myrtaceae including Eucalyptus and Melaleuca are susceptible to infection to various degrees. Plants infected by A. psidii can suffer from crown loss and eve

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22

Ravenscroft, Harriet. "Defence mechanisms of dental pulp stem cells." Thesis, Queen's University Belfast, 2018. https://pure.qub.ac.uk/portal/en/theses/defence-mechanisms-of-dental-pulp-stem-cells(0e1880c7-13b4-4072-86c6-4b52a05d5175).html.

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23

Sundbom, Elisabet. "Borderline psychopathology and the defense mechanism test." Doctoral thesis, Umeå universitet, Institutionen för psykologi, 1992. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100698.

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The main purpose of the present studies has been to develop the Defense Mechanism Test (DM1) for clinical assessment of severe psychopathology with the focus on the concept of Borderline Personality Organization (BPO) according to Kemberg. By relating the DMT and the Structural Interview to each other, the concurrent validity of the concept of Personality Organization (PO) for psychiatric inpatients has been investigated. Two different assessment approaches have been used for this purpose. One has been to take a theoretical perspective as the starting-point for the classification of PO by mean

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24

O'Donovan, Lisa Anne. "Mechanisms of defence against tannins by Streptococcus caprinus /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09NP/09anpo26.pdf.

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25

Stanley, P. "Host defence mechanisms of the upper respiratory tract." Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47263.

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26

Crampton, Bridget Genevieve. "Elucidation of defence response mechanisms in pearl millet." Thesis, Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-10132008-143627.

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27

Joshi, Nimisha. "Bactericidal mechanisms of nanoparticles and microbial defence strategies." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/12223.

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Manufactured nanoparticles can be toxic to living organisms. This work aims to study the interaction of nanoparticles with bacteria as a model organism. The first objective was, to determine the mechanistic pathways of nanotoxicity with an emphasis on ions and oxidative stress as two key contributors and the second objective, was to investigate what mechanisms bacteria have developed as a strategy to protect themselves against nanotoxicity. The thesis further explores the role of environmental variables such as water chemistry, organic matter and other microorganisms, all of which can potentia

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28

Holloway, Laurin Nicole. "Host Defense Mechanisms Against Mycobacterium Tuberculosis." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1245878489.

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29

Jordan, Nicholas David. "Partial purification and characterisation of a wheat N-acetyl-#beta#-D-hexosaminidase and its role in defensive lignin deposition." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240956.

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30

Silverberg, Kristen Elisabeth. "Defense spending as a mechanism for reducing U.S. unemployment." Connect to Electronic Thesis (CONTENTdm), 2010. http://worldcat.org/oclc/646275696/viewonline.

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31

Ormrod, Douglas James. "Modulation of non-specific cellular defence mechanisms by cyclosporin A." Thesis, University of Auckland, 1990. http://hdl.handle.net/2292/3195.

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The immune response modifier Cyclosporin A (CsA) is widely used in the management of organ graft rejection and in the treatment of inflammatory disorders. CsA is a potent suppressor of T-lymphocyte function and it’s biological effects have been defined almost exclusively in these terms. However, recent studies in which the agent was shown to exacerbate a T-lymphocyte independent, experimentally induced bacterial infection of the kidney (pyelonephritis), indicated that CsA had effects on host defence mechanisms other than T-lymphocytes. The present study, using animal models, was undertaken to

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32

Pipe, R. K. "Haemocytes of the mussel Mytilus edulis : aspects of defence mechanisms." Thesis, Swansea University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638536.

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The blood cells of the common blue mussel <i>Mytilus edulis</i> have been characterized using a range of criteria including, electron microscopy, lectin-affinity and enzyme localization. Three distinct sub-populations of haemocyte have been identified; these can be characterized on the basis of ultrastructural morphology as small agranular cells, granular cells containing small granules and granular cells containing large granules. Lectin-binding studies have shown the small granules of the granular cells to be positive for <i>Helix pomatia</i> lectin (HPA) indicating the presence of N-acetyl-

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33

Adams, Nicolette. "Investigation of defence mechanisms against Botrytis cinerea in Arabidopsis thaliana." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/4235.

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Includes bibliographical references (leaves 63-86).<br>Disease resistance in plants has been extensively studied for the past century with many new and exciting results being discovered each year. A plant utilises both preformed and induced defence responses to resist pathogen attack but researchers have focused on dissecting the induced defence response pathway. The complex signal transduction pathway underlying the establishment of resistance to a wide range of pathogen attack is currently being dissected using Arabidopsis thaliana as a model organism. Arabidopsis mutants displaying altered

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34

Lee, Min-Hi. "Induction and regulation of antiviral defence mechanisms through intracytoplasmic sensors." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15950.

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Das Wechselspiel zwischen Viren und ihren Wirtszellen beginnt meist an pattern recognition-Rezeptoren (PRRs), die für die Erkennung unterschiedlichster Pathogene anhand bestimmter Strukturen, sogenannten pathogen-associated molecular patterns (PAMPs), zuständig sind. Nach Detektion lösen die PRRs über verschiedene Signalkaskaden eine antivirale Antwort aus, die zur Expression antiviraler Gene führt. RIG-I und MDA5 sind zytoplasmatisch lokalisierte PRRs und erkennen RNA-Strukturen, die insbesondere während der viralen Replikation und Transkription verfügbar sind. Hantaviren sind humanpathogene

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35

Vallance, Lisa. "Aspects of defence : discourse of veterans, research regarding current UK forces and veterans and working around defence mechanisms." Thesis, City University London, 2012. http://openaccess.city.ac.uk/3022/.

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Veterans seeking psychological input for mental health issues, following service with the UK Armed Forces, report difficulties in relating to mental health practitioners, often causing them to disengage with therapy. A wealth of quantitative research including epidemiology studies and outcome reports is available for this client group as well as best practice of treating mental health issues including combat-related post-traumatic stress disorder. More qualitative studies are being produced, both for this client group and their associated mental health issues. However, there appears to be a pa

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36

Shackleton, Kyle. "Novel aspects of nest defence in stingless bees." Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/76550/.

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Defence against predators is fundamental to increasing an organism's fitness. My thesis explores this central theme in behavioural ecology using stingless bees as study organisms. The thesis contains a general introduction (Chapter 1), three data chapters (2-4) and a final discussion (5). Chapter 2 is a comparative study of aggression in nest defence among stingless bee species, and describes a new form of nest defence, suicidal biting, which is most prevalent in the genus Trigona. Chapter 3 describes a remarkable behaviour in Partamona helleri, which crashes head-first when entering its nest.

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37

MacGregor, Michael William. "Ego mechanisms of defense revisited, the relation of defense profiles to personality and health." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ57356.pdf.

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38

Hellström, Magnus, and Erik Forsgren. "Contagious Defenses : Interaction of Emotional Contagion and Defense Styles in a Business Context with Regard to the Resistance to Change." Thesis, Blekinge Tekniska Högskola, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-19923.

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Companies have always had to adapt to external changes by innovation and reorganisation, in order to stay competitive and survive. For many industries, such as the automotive industry for example the need to quickly adapt to new conditions is expected to increase. In the automotive industry this is due to amongst other factors the globalised value chains and megatrends such as decarbonisation, autonomous vehicles and shared mobility. The megatrends could possibly be disruptive for the industry. Therefore, the ability to successfully implement necessary changes is a key ability. Defense mechani

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39

Tang, M. "Elicitor-induced defence response and signal mechanisms in Medicago sativa L." Thesis, Swansea University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639158.

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In this study, the responses and signal mechanisms were explored with a model system, concerning the interactions between lucerne suspension cells (<I>Medicago sativa</I> L., cv. Kabul) and elicitor either from avirulent (V2) or virulent (V1) isolate of <I>Verticillium, alboatrum</I>. V2 elicitor induced a two-phase of H<SUB>2</SUB>O<SUB>2</SUB> accumulation in the cell cultures. Activation of defence expression led to an increase in PAL activity, phytoalexin accumulation and deposition of phenolic polymers. However, activities of antioxidant enzymes, such as catalase, peroxidases, glucanase,

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40

Wilkinson, J. R. "The role of mitochondria in defence mechanisms of human endothelial cells." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/147918/.

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Introduction: Mitochondria are considered to be the powerhouse of the cell being the primary generators of ATP, they also have numerous other important functions including; being the main generator of reactive oxygen species (ROS) and a central role in apoptosis. As the main intracellular source of ROS, many people believe that mitochondria play a significant role in ageing. Senescence is associated with ageing and has been associated with atherosclerotic vascular disease. The concept of human cells lacking functional mitochondria (Rho 0 cells) is not new and was first described by Attardi et

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VAEZI, ANZEHA ZAHRA. "Host defence peptides: mechanisms of membrane perturbation and target cell selectivity." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/201991.

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Host defence peptides (HDPs) are effector molecules of the innate immune system. They show broad activity against bacteria and cancer cells, usually by perturbing the permeability of cell membranes, leading to the death of pathogens by collapse of transmembrane electrochemical gradients and loss of important metabolites and cellular components. Due to this mechanism of action, development of resistance is unlikely. For this reason, HDPs are excellent candidates as a new class of therapeutics to address the problem of drugresistance pathogens. Pore formation in the pathogen membranes requires a

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42

Clementson, Christian. "Client-side threats and a honeyclient-based defense mechanism, Honeyscout." Thesis, Department of Electrical Engineering, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-20104.

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<p>Client-side computers connected to the Internet today are exposed to a lot malicious activity. Browsing the web can easily result in malware infection even if the user only visits well known and trusted sites. Attackers use website vulnerabilities and ad-networks to expose their malicious code to a large user base. The continuing trend of the attackers seems to be botnet construction that collects large amounts of data which could be a serious threat to company secrets and personal integrity. Meanwhile security researches are using a technology known as honeypots/honeyclients to find and an

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43

Fried, Limor. "Social defense mechanisms : tools for reclaiming our personal space." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33151.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.<br>Includes bibliographical references (leaf 67).<br>In contemporary Western society, electronic devices are becoming so prevalent that many people find themselves surrounded by technologies they find frustrating or annoying. The electronics industry has little incentive to address this complaint; I designed two counter-technologies to help people defend their personal space from unwanted electronic intrusion. Both devices were designed and prototyped with reference to the cultu

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44

Jakobsson, Tina. "The Defense Mechanisms of Moll Flanders : A Psychoanalytical Essay." Thesis, Högskolan i Gävle, Avdelningen för humaniora, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-35152.

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The essay analyzes how and why Moll Flanders’s childhood created mental and emotional patterns that would come to shape her personality and affect her behavior. The analysis will use psychoanalytical theories by Sigmund Freud and Jacques Lacan to discern what defense mechanisms and desires Moll developed in childhood and how these presented themselves throughout her life. The essay concludes that she has a fear of abandonment and intimacy and that she uses denial and sublimation to repress anxiety and guilt. Moll’s core desire is to find stability, which is why she continuously strives for fin

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45

Scheiding, Victoria [Verfasser]. "Immune defense mechanisms against Legionella longbeachae / Victoria Madeleine Scheiding." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1206417552/34.

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Scheiding, Victoria Madeleine [Verfasser]. "Immune defense mechanisms against Legionella longbeachae / Victoria Madeleine Scheiding." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1206417552/34.

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47

Jansson, Marianne. "HIV-1 variability in relation to host defence mechanisms and disease outcome /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980608jans.

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48

Crumlish, Margaret. "A study on the innate defence mechanisms in farmed tropical Rana spp." Thesis, University of Stirling, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321973.

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49

Zhang, Shaoli. "Molecular aspects of pancreatic islet cell defence mechanisms in Type I diabetes." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240906.

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50

Nedoboy, Polina. "Myeloperoxidase-derived oxidants: their Intracellular targets, defence mechanisms and role in disease." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/9910.

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Myeloperoxidase, a heme enzyme secreted by activated phagocytes at sites of inflammation, catalyses the oxidation of Cl- and SCN- to HOCl and HOSCN, which play an essential role in innate immunity. The misregulated production of these oxidants can be detrimental to the host. Thiocyanate is a preferred substrate of MPO, and higher SCN- levels are present in the plasma of smokers, suggesting that HOSCN formation may contribute to the enhanced risk of atherosclerosis (and other diseases) in smokers. The studies described in this thesis used both plasma samples, and the murine macrophage-like J77

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