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Relevant bibliographies by topics / Degenerative disc disease

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Academic literature on the topic 'Degenerative disc disease'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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Journal articles on the topic "Degenerative disc disease"

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R.Ya, Abdullaiev. "Ultrasonic Imaging of Lumbar Degenerative Disc Disease." Spinal Diseases and Research 2, no. 1 (March 20, 2019): 01–02. http://dx.doi.org/10.31579/jsdr.2019/016.

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Bhanushali, Riya. "Regeneration Potential of Stem Cell in the Treatment of IVD." International Journal for Research in Applied Science and Engineering Technology 9, no. 8 (August 31, 2021): 3022–36. http://dx.doi.org/10.22214/ijraset.2021.37908.

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Abstract: Degenerative disc disease is a prevalent musculoskeletal disorder in which damaged spinal discs cause pain upon aging, accidental injuries. Spinal discs connect adjacent vertebrae and help in maintaining mobility, flexibility and rotation of spinal cord. Spinal discs also act as shock absorbers. Intervertebral disc (IVD) degeneration is often associated with low back and neck pain, which accounts for disability worldwide. Physical therapy, spinal fusion surgeries reduce severity and symptoms of degenerative disc disease but they are not complete cure for this disease. Current preclinical studies show that mesenchymal stem cells have the capacity to repair degenerative disks by differentiation to chondrocyte-like cells, which produce proteoglycans and type II collagen. Mesenchymal stem cells (MSCs) isolated from bone marrow (BM-MSCs), adipose tissue (AD-MSCs) and umbilical cord (UC-MSCs) show potential use in cartilage and intervertebral disc (IVD) repair. Regenerative medicine and stem cell therapy hold great promise for treatment of intervertebral disc (IVD) disease. This review discusses about progression of degenerative disc disease, various types of stem cells, potential use of mesenchymal stem cells (MSCs) and embryonic stem cells (ESCs) for the treatment of degenerative disc disease. This review also focuses upon challenges encountered by the application of stem cell therapy for treating degenerative disc disease as well as future perspectives. Keywords: IVD, Stem cell therapy, AF & NP cells, MSCs, Scaffolds, Cell therapy

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Abdullaiev, R. Ya, K. M. Ibragimova, I. H. Mamedov, and R. R. Abdullaiev. "DEGENERATIVE DISC DISEASE IN YOUNG PEOPLE. MEDICAL IMAGING TECHNIQUES." International Medical Journal, no. 1 (March 5, 2020): 48–52. http://dx.doi.org/10.37436/2308-5274-2020-1-10.

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Degenerative changes of intervertebral discs is a very complicated process as a result of interaction of many factors: genetic, environmental, physical activity. Abnormalities in the vertebrae structure create the preconditions for the overload of the vertebral motor segment, which contributes to the spread of degenerative lesions and increases the risk of spinal injuries. Degenerative disc disease is one of the most common causes of back pain. The process of degeneration begins at a young age and in adulthood it often becomes widespread with a predominance of one or another localization. Methods of medical imaging occupy an important place in diagnosis of musculoskeletal pathologies. Radiography assesses the changes only in bone structures, but does not allow the visualization of soft tissues, which include not only the ligaments of the vertebral motor segment, but also the intervertebral discs. Magnetic resonance imaging is the most effective method for diagnosing degenerative changes in intervertebral discs. Possibilities of ultrasound examination in the diagnosis of early stage degenerative disc disease have not been studied enough. There were examined 147 patients aged 18−27 years with clinical and neurological signs of degenerative disease of cervical and lumbar spinal discs. Ultrasonic semiotics showed changes within the pulpal nucleus as an increased echogenicity and displacement back towards the fibrous ring, fibrous ring thinning, which indicated the disc protrusion. In patients with pain in neck and lower back, fragmentary imaging of the fibrous ring and prolapse of the disc contents into the lumen of spinal canal, indicating the development of hernias was found. The presence of herniated discs of cervical and lumbar spine in all cases coincided with the results of magnetic resonance imaging, and protrusion did in 91,4 % of cases. Thus, among medical imaging the ultrasonography is the most accessible and informative method for diagnosing degenerative changes in intervertebral discs of cervical and lumbar spine. Key words: degenerative disc disease, ultrasonography, cervical and lumbar intervertebral discs.

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Battié, Michele C., Anand B. Joshi, and Laura E. Gibbons. "Degenerative Disc Disease." SPINE 44, no. 21 (November 2019): 1523–29. http://dx.doi.org/10.1097/brs.0000000000003103.

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Milette, P. C. "Degenerative Disc Disease." Rivista di Neuroradiologia 16, no. 5 (October 2003): 759–61. http://dx.doi.org/10.1177/197140090301600514.

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EVEN-SAPIR, EINAT, and ROBERT H. MARTIN. "Degenerative Disc Disease." Clinical Nuclear Medicine 19, no. 5 (May 1994): 388–92. http://dx.doi.org/10.1097/00003072-199405000-00002.

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Dehn, Tom. "Degenerative Disc Disease: Disc Replacement." Annals of The Royal College of Surgeons of England 89, no. 1 (January 2007): 6. http://dx.doi.org/10.1308/003588407x160792.

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Alkhasawneh, Mahmoud H., Asma’a Al-Mnayyis, and Yazeed Bagain. "Spinal Degeneration and Degenerative Disc Disease correlation identified with Magnetic Resonance Imaging." Biomedical and Pharmacology Journal 14, no. 1 (March 30, 2021): 491–96. http://dx.doi.org/10.13005/bpj/2149.

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Magnetic resonance imaging (MRI) is the golden standard technique for spine disc disease diagnosis. Vertebral body endplate signal intensity on MRI is confirming lumber spine degenerative disc disease.The study aimed to record the lumbar spine degenerative relation between disc and diseaseusing magnetic resonance imaging. Our prospective and double blind investigation included 142 participants,having lumbar spine degenerativedisease confirmed by MRI. Pfirrmann score was used to record the relation between lumbar spine disc degeneration and lumbar spine degenerative disease. Modic modifications with the Pfirrmann and modified Pfirrmann scores of disc degeneration were assessed.Lumbar spine MRI was done for all participants using sagittal T1 and T2 WI. Modic was scored (0-III) The Pfirrmann scored I-V for disc degeneration. Lumbar disc degeneration was evaluated by modified Pfirrmann scoring from 1-8 according to signal intensity of the nucleus pulposus and inner annulus.Modic was recorded in 41.5%, 24.6%, 32.4% and 1.4% of participants with scores 0, I, II and III, respectively. Pfirrmann score was 13.4%, 73.9% and 12.7% of disc degeneration with scores III, IV and V, respectively, while,the modified Pfirrmann score was 2.1%, 15.5%, 38.7%, 26.8% and 16.9% of disc degeneration with scores of 4, 5, 6, 7 and 8, respectively. The modified Pfirrmann score showed notableinconsistencyin participants with Modic 0, I and II, but no difference between Modic I and II.There was significant relation between Modicand lumbar spine disc degeneration. In conclusion, there is a relation between Modic, Pfirrmann and modified Pfirrmann scores of lumbar spine disc degeneration in participants with lumbar spine degenerative disease.

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Gul, Nadia, Khalid Mehmood, and Muhammad Ikram. "RETROSPECTIVE DATA REVIEW TO FIND THE ASSOCIATION OF LUMBOSACRAL TRANSITIONAL VERTEBRA AND DEGENERATIVE DISC DISEASE IN YOUNG PATIENTS." Pakistan Armed Forces Medical Journal 70, no. 6 (December 15, 2020): 1734–39. http://dx.doi.org/10.51253/pafmj.v70i6.3997.

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Objective: To find out the frequency of lumbar disc degeneration among the patients having lumbosacraltransitional vertebra between 20-40 years. Study Design: Retrospective cross sectional study. Place and Duration of Study: Radiology department POF Wah Cantt, from Jan 2018 to Dec 2019. Methodology: Six Hundred patients between 20-40 years having lumbosacral transitional vertebra and historyof low back pain >1 year were studied. X ray and MRI lumbar spine of these patients was studied retrospectivelyon PACS. Two hundred patients having history of traumatic or other non-traumatic etiologies, in addition toLumbosacral transitional vertebra were excluded. Four hundred patients with only lumbosacral transitionalvertebra were included. Data analysis was done by SPSS-22. Castellvi types of transitional vertebra was calculated among patients with degenerative lumbar disc. Results: One hundred and four (26.6%) were having degenerative disc disease while 296 (74.4%) patients werenot having degenerative disc disease. Patients having degenerative disc disease were between 24-40 years withthe mean age 29.96 ± 0.417 years. Among the patients having degenerative disc disease were 59 women and45 males but no statistical significance association was found between gender and degenerative disc disease with p-value = 0.55. Castellvi type III had significant association with degenerative disc disease, p-value = 0.006. Conclusion: Age related disc degeneration is commonly seen in middle age people but in younger age group in2nd and 3rd decade it is observed frequently in those patients having lumbosacral transitional vertebra especially in the setting of no other associated traumatic or non-traumatic etiology, which leads to early degenerative disc disease.

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Taher, Fadi, David Essig, Darren R. Lebl, Alexander P. Hughes, Andrew A. Sama, Frank P. Cammisa, and Federico P. Girardi. "Lumbar Degenerative Disc Disease: Current and Future Concepts of Diagnosis and Management." Advances in Orthopedics 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/970752.

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Low back pain as a result of degenerative disc disease imparts a large socioeconomic impact on the health care system. Traditional concepts for treatment of lumbar disc degeneration have aimed at symptomatic relief by limiting motion in the lumbar spine, but novel treatment strategies involving stem cells, growth factors, and gene therapy have the theoretical potential to prevent, slow, or even reverse disc degeneration. Understanding the pathophysiological basis of disc degeneration is essential for the development of treatment strategies that target the underlying mechanisms of disc degeneration rather than the downstream symptom of pain. Such strategies ideally aim to induce disc regeneration or to replace the degenerated disc. However, at present, treatment options for degenerative disc disease remain suboptimal, and development and outcomes of novel treatment options currently have to be considered unpredictable.

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Dissertations / Theses on the topic "Degenerative disc disease"

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Jim, Jin-to. "Genetics and molecular characterization of degenerative disc disease." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B35720189.

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Jim, Jin-to, and 詹展韜. "Genetics and molecular characterization of degenerative disc disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B35720189.

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袁敏婷 and Minting Yuan. "A collagen microencapsulation : assisted stem cell-based approach for treating degenerative disc disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/193390.

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Degenerative disc disease (DDD) is a medical condition whereby the intervertebral discs (IVD) of the human spine degenerates and may cause pain which significantly affects the quality of one掇 life. Its prevalence has sparked off much research in deciphering its causes and developing new treatments. Recently, attempts to treat this degenerative problem have turned to seeking answers from regenerative medicine. One approach is to deliver mesenchymal stem cells (MSCs) with or without carriers to the nucleus pulposus (NP) in degenerative disc to restore both its structural and functional properties. However, the optimal conditions and signals for inducing MSCs differentiation toward NP-like phenotype have not been identified. This work aimed to develop injectable microspheres with matrix microenvironment mimicking that of native NP tissue for MSCs delivery. Firstly, it was aimed to establish a collagen microencapsulation based 3D culture system for maintenance of the phenotype of nucleus pulposus cells (NPCs) and remodeling of the collagen matrix to one that was similar to the native NP. Secondly, it was aimed to optimize a decellularization protocol for complete removal of the encapsulated NPCs with minimal loss of remodeled extracellular matrix. Thirdly, it was aimed to investigate whether this acellular matrix produced by NPCs was inductive for MSCs discogenic differentiation. Finally, it was aimed to evaluate the efficacy of the MSC-seeded acellular matrix microspheres in a pilot rabbit disc degeneration model. It demonstrated that NPCs maintained their phenotype, survived within the collagen microspheres and produced NP-like ECM such as glycosaminoglycan (GAG) and collagen type II. GAG production of NPCs was found to positively correlate with the dosage of TGF-? within a short period, initial collagen concentration and cell seeding density. An optimized decellularization protocol with 50mM SB-10, 0.6mM SB-16 and 0.14% Triton X-200 was established to completely remove the encapsulated NPCs with partial retention of the GAG-rich matrix. The decellularized microspheres were able to be repopulated with human MSCs (hMSCs) or rabbit MSCs (rMSCs). Within the NPC-derived acellular matrix, the repopulated hMSCs were able to partially exhibit NPC phenotype with upregulated expression of a few NPC markers and NP-like ECM according to histological, biochemical, immunohistological and real-time PCR results. In the pilot in vivo evaluation study, preliminary results showed that intra-discal injection of MSCs reseeded acellular NPC-matrix microspheres maintained a better water content than the control MSC-microspheres without the NPC-derived acellular matrix. This work reconstituted in vitro a NP-like 3D matrix and provided preliminary evidence on discogenic differentiation of MSCs in such a matrix environment. This work laid down the foundation to future development of stem cell-based therapies for DDD. Further studies should focus on deciphering the soluble and insoluble composition of such a NP-like matrix environment and understanding the molecular mechanism of the cell-matrix interactions involved.
published_or_final_version
Mechanical Engineering
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Doctor of Philosophy

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Lam, To-kam, and 林吐金. "In vivo study of asporin polymorphic variants in chondrogenesis and degenerative disc disease (DDD)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42182591.

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Lam, To-kam. "In vivo study of asporin polymorphic variants in chondrogenesis and degenerative disc disease (DDD)." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42182591.

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Blumenkrantz, Gabrielle. "Characterizing magnetic resonance relaxation times in the extracellular matrix in osteoarthritis and degenerative disc disease." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390033.

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Thesis (Ph.D.)--University of California, San Francisco with the University of California, Berkeley, 2009.
Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: . Adviser: Sharmila Majumdar.

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Lim, Tonny. "Proteomic analysis of human cerebrospinal fluid from patients with painful and non-painful degenerative disc disease." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32362.

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One of the primary causes of persistent lumbar back pain is degenerative disc disease (DDD). In most persons, DDD is a normal process occurring with natural age, while in others, DDD results in chronic pain. While imaging techniques can be used to detect degenerative changes, there is a low correlation between the extent of degenerative changes and the pain found upon physical evaluation, suggesting biochemical factors may be involved with the persistent pain state. The purpose of this study was to examine human cerebrospinal fluid (CSF) for changes in protein expression using high throughput proteomics technology, which would help to identify biochemical factors involved with DDD and low back pain. Differences at the protein level were observed in the CSF of persons with asymptomatic and painful degenerative disc disease. Markers of inflammation were altered in patients with degenerative disc disease. In the case of painful degenerative disc disease, our results suggest altered neuropeptide processing and nerve damage may be playing a role in the disease.
L'une des causes de la lombalgie chronique est la maladie degenerative lombaire (MDL). Chez la plupart des gens, ce processus se développe normalement au cours du vieillissement, alors que chez d'autre gens, la MDL cause de la douleur chronique. Alors que les techniques d'imageries peuvent être utilisées pour détecter la dégénérescence des disques, il y a une faible correlation entre l'étendue de la dégénérescence et la douleur ressentie à l'évaluation médicale. Il est donc possible que des facteurs biochimiques soient impliqués dans le dévellopement et la maintenance de la douleur chronique, mais qu'ils soient indétectables par imagerie. Le but de cette étude est d'analyser le liquide céphalo-rachidien (LCR) de l'humain afin de mesurer les changements d'expression de proteins et ainsi, d'identifier les facteurs biochimiques impliqués dans la MDL. Des différences au niveau des protéines ont été observées entre le CSF de personnes asymptomatiques et de personnes souffrant de la MDL avec douleur. Marqueurs inflammatoires ont été altérés chez les patients présentant la MDL. Dans le cas des patients ayant la MDL avec douleur, il est possible que le métabolisme des neuropeptides et des dommages aux terminaisons nerveuses jouent un role dans la pathologie.

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Espahbodi, Shima. "Investigation of lumbar artery haemodynamics in patients with low back pain and degenerative disc disease of the lumbar spine." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416129.

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Hohaus, Christian. "Autologe Zelltransplantation bei degenerativen Bandscheibenveränderungen an der Lendenwirbelsäule." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-109725.

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Degenerative Veränderungen der Lendenwirbelsäule beginnen bereits im Alter von unter 20 Jahren und betreffen vor allem die unteren 3 Bewegungssegmente. Die degenerativen Veränderungen an der Bandscheibe gehen mit einer Kalzifizierung der Grund- und Deckplatten der Wirbelkörper einher, was zu einer Reduktion der Nährstoffversorgung der Bandscheibe und damit zu einem Untergang der matrixbildenden Zellen und konsekutiv zu einem Flüssigkeitsverlust in der Bandscheibe führt. Als Folge nimmt die Belastung der Bandscheibe weiter ab. Die aktuellen Therapieoptionen umfassen sowohl die konservative als auch die operative Therapie, wobei allerdings nur die Folgen der Degeneration behandelt werden. Ziel einer Zelltransplantation ist es, der Bandscheibe wieder matrixbildende Zellen zur Verfügung zu stellen, damit die nutritiven Veränderungen auszugleichen und eventuell reversibel zu machen. Dieser Effekt konnte im Tierversuch nachgewiesen werden, woraufhin eine klinische Studie initiiert wurde. Im Rahmen der publizierten klinischen prospektiven, randomisierten Studie konnte gezeigt werden, dass die Transplantation autologer Chondrozyten, die bei einer notwendigen operativen Therapie eines sequestrierten Bandscheibenvorfalls gewonnen wurden, einen sowohl klinisch als auch bildmorphologisch positiven Effekt auf die degenerierten Bandscheiben hat. Es kam zu einer signifikanten Reduktion der Schmerzsymptomatik und einer Steigerung der Lebensqualität in der Gruppe der transplantierten Patienten. Die Bandscheibenhöhe zeigt sich stabil über den Beobachtungszeitraum von 2 Jahren.

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Wan, Simon. "Self-assembling peptide hydrogel for intervertebral disc tissue engineering." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/selfassembling-peptide-hydrogel-for-intervertebral-disc-tissue-engineering(1f931e1e-6b9b-49a7-bd30-2572ff0338fa).html.

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The intervertebral disc (IVD), situated between adjoining vertebrae, consists of the gelatinous nucleus pulposus (NP) in the centre surrounded by the tougher annulus fibrosus (AF). Its main roles are to distribute loads and to act as joints. With aging, degenerative disc disease (DDD) occurs due to an imbalance in anabolic and catabolic events in the IVD, which results in a loss of function. Lower back pain (LBP) affects 84% of people at some point in their lifetime and is strongly associated with DDD. Current LBP treatments have limited long term efficacy and are symptomatic rather than curative. Cell-based therapies are regarded to hold great potential for the treatment of DDD as it has been hypothesised that they could regenerate the damaged tissue and alleviate LBP. A number of natural and synthetic biomaterials have been investigated as NP tissue engineering scaffolds with varying results. In this study, a self assembling peptide hydrogel (SAPH) was investigated for its potential as a cell carrier and/or scaffold for NP tissue engineering. SAPHs display the advantages of natural polymer hydrogels such as biocompatibility and biodegradability whilst combining the advantages of synthetic materials such as controlled structural and mechanical propertiesCharacterisation determined that the SAPH nanofibrous architecture had features that were of similar scale to extracellular matrix (ECM) components of the human NP. The mechanical properties of the SAPH could be optimised to closely match the native tissue. The system could shear thin and self-heal making the system ideally suited to delivery via minimally invasive procedure. The three dimensional (3D) culture of bovine NP cells (bNPCs) in the SAPH demonstrated that the NP phenotype could be restored after de-differentiation during monolayer culture. Gene expression results demonstrated that ‘traditional’ and ‘novel’ NP markers were highly expressed throughout in vitro culture. Cell viability was high, cell population remained stable and bNPCs adopted the characteristic rounded morphology of native NPCs. Finally, type II collagen and aggrecan, the main ECM components of the NP, were deposited with increasing production over culture period. Growth differentiation factor 6 (GDF-6) has been identified as the most promising current growth factor for inducing discogenic differentiation from human bone marrow mesenchymal stem cell (h-BMMSCs). After samples were stimulated with GDF-6, gene expression results confirmed that a NP-like phenotype could be induced with high expression of ‘traditional’ and ‘novel’ NP markers. Cell viability was high, cell population remained stable and NP associated ECM components were deposited with cells displaying a rounded morphology. Interestingly, when h-BMMSCs were cultured without GDF-6, it was strongly suggested that spontaneous discogenic differentiation occurred after culture in the SAPHs as ‘traditional’ and ‘novel’ NP markers were highly expressed, morphology was comparable to native NPCs and type II collagen and aggrecan were deposited extracellularly. If these findings were accurate then this is the first study to demonstrate that a NP-like phenotype could be induced from MSCs without use of an exogenous growth factor or a discogenic bioactive motif. Despite exciting and novel results, further work is required to confirm the potential of SAPHs for NP tissue engineering scaffolds.

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Books on the topic "Degenerative disc disease"

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Manfrè, Luigi, and Johan Van Goethem, eds. The Disc and Degenerative Disc Disease. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-03715-4.

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Parker, Philip M., and James N. Parker. Degenerative disc disease: A medical dictionary, bibliography, and annotated research guide to internet references. San Diego, CA: ICON Health Publications, 2004.

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Pansini, Arnaldo. Median longitudinal cervical somatotomy: Surgical treatment of cervical myelopathy due to degenerative disc disease and syndromes resulting from fracture-dislocation of the cervical spine. [Padua?]: Piccin, 1986.

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Pinheiro-Franco, João Luiz, Alexander R. Vaccaro, Edward C. Benzel, and H. Michael Mayer, eds. Advanced Concepts in Lumbar Degenerative Disk Disease. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47756-4.

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Robert, Gunzburg, Szpalski Marek, and Andersson Gunnar 1942-, eds. Degenerative disc disease. Philadelphia: Lippincott Williams & Wilkins, 2004.

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Degenerative disc disease. Philadelphia, PA: Lippincott Williams & Wilkins, 2003.

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Szpalski, Marek, Robert Gunzburg, and Gunnar BJ Andersson. Degenerative Disc Disease. Lippincott Williams & Wilkins, 2003.

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Gamon, Ben. Degenerative Disc Disease Pain Relief Plan. CreateSpace Independent Publishing Platform, 2011.

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Manfrè, Luigi, and Johan Van Goethem. The Disc and Degenerative Disc Disease: Remove or Regenerate? Springer, 2020.

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Dworkin, Ian, Daniel A. Fung, and Timothy T. Davis. Biologic and Regenerative Therapies. Edited by Mehul J. Desai. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199350940.003.0027.

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Low back pain is one of the most debilitating conditions worldwide, and a major cause is degenerative disc disease. Current therapies range from conservative treatments, such as medications, physical therapy, and other modalities, to more invasive treatments such as injections and surgery; however, these therapies neither stop the progression of degeneration nor restore function to the degenerating disc; they focus on symptom management, not on etiology. A novel approach to treating degenerative disc disease involves using regenerative therapies such as stem cells, growth factors, and gene therapy. The goal of these therapies is not just to decrease symptoms, but to reverse disc degeneration, while simultaneously enhancing current treatment modalities. Though clinical translation of regenerative therapies is in its infancy, in vitro and in vivo investigations have revealed these therapies’ potential in treating degenerative disc disease as well as a multitude of other musculoskeletal conditions.

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Book chapters on the topic "Degenerative disc disease"

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Parizel, Paul M., Johan W. M. Van Goethem, Luc Van den Hauwe, and Maurits Voormolen. "Degenerative Disc Disease." In Spinal Imaging, 127–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-68483-1_6.

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Goel, Aneesh P., Eric J. Wang, and Mark C. Bicket. "Degenerative Disc Disease." In Spine Pain Care, 181–88. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-27447-4_14.

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Van den Wyngaert, Tim. "Degenerative Spine – Degenerative Disc Disease." In Clinical Atlas of Bone SPECT/CT, 1–2. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-32256-4_89-1.

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Beall, Douglas P., Dereck D. Wagoner, Timothy T. Davis, Timothy Ganey, Edward Yoon, Brooks M. Koenig, Jennifer Witherby, and H. Thomas Temple. "New Biomaterials for Degenerative Disc Disease." In The Disc and Degenerative Disc Disease, 273–309. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-03715-4_13.

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Thurnher, Majda M., and Johan Van Goethem. "Conventional Neuroradiology of Degenerative Disc Disease." In The Disc and Degenerative Disc Disease, 77–95. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-03715-4_4.

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Kumar, Sumeet, and Vivek Pai. "Anatomy and Biomechanics of the Intervertebral Disc." In The Disc and Degenerative Disc Disease, 1–17. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-03715-4_1.

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Bonaldi, Giuseppe, and Alessandro Cianfoni. "Minimally Invasive Treatment of Herniated Discs: How to Remove the Disc with Physical Tools." In The Disc and Degenerative Disc Disease, 185–217. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-03715-4_10.

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Yorukoglu, Ali Guven, Luigi Manfrè, and Altay Sencer. "Endoscopic Percutaneous Discectomy." In The Disc and Degenerative Disc Disease, 219–39. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-03715-4_11.

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Becker, Stephan. "Regenerative Options to Restore the Disc." In The Disc and Degenerative Disc Disease, 241–71. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-03715-4_12.

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Elhawary, Youssry, and Mohamed Fawzy Khattab. "Surgical Disc Replacement and Fusion Techniques." In The Disc and Degenerative Disc Disease, 311–26. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-03715-4_14.

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Conference papers on the topic "Degenerative disc disease"

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Wang, Shaobai, Michal Kozanek, Kirkham B. Wood, and Guoan Li. "Lumbar Degenerative Disc Disease Increases Deformations at Cephalad Adjacent Levels In Vivo." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19629.

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Low back pain, one of the most common causes of disability in working population is in the vast majority of cases attributed to degeneration of the lumbar intervertebral disc (IVD). It has been reported that in patients with degenerative disc diseases (DDD) at one level, the discs adjacent to the diseased level have a greater tendency to degenerate. Studies have also suggested altered biomechanics as causative factors [1, 2]. However, to date no data has been reported on the deformation of the disc in vivo in DDD patients. The purpose of this study was to evaluate the effect of lumbar IVD degeneration on the deformation of the discs at the adjacent levels during functional weightbearing postures.

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Ryan, Thomas P. "Thermal therapy for degenerative disc disease." In BiOS 2001 The International Symposium on Biomedical Optics, edited by Thomas P. Ryan. SPIE, 2001. http://dx.doi.org/10.1117/12.427858.

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Tashtoush, Abdullah. "Therapeutic Degenerative Disc Disease Using Disc Rehabilitation Table (DRT)." In 2015 IEEE European Modelling Symposium (EMS). IEEE, 2015. http://dx.doi.org/10.1109/ems.2015.18.

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Li, S., A. Lin, K. Tay, W. Romano, and Said Osman. "Prognosis of intervertebral disc loss from diagnosis of degenerative disc disease." In SPIE Medical Imaging, edited by Lubomir M. Hadjiiski and Georgia D. Tourassi. SPIE, 2015. http://dx.doi.org/10.1117/12.2082727.

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Natarajan, Raghu N., Jigar Gorasia, and Gunnar Andersson. "Generation of Grade Specific Finite Element Model of Lumbar Spines." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14123.

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The anatomy and biomechanics of the intervertebral motion segments is complex, and the development of degenerative motion segment disorders, which occur frequently, is poorly understood. When disc degeneration occurs at one level, whether treated or not, degeneration frequently develops at mobile segments above or below the degenerated or treated segments. After surgical treatment the process is referred to adjacent segment disc disease (ASDD), and the condition clinically called transition syndrome. We do not know at this time if the ASDD is caused by the neighboring degenerated disc or if they represent the natural progression of the lumbar degenerative processes. The development of ASDD is clinically problematic because it can cause pain and necessitate further surgical intervention. The development and severity of ASDD in disc degeneration is broadly believed to depend on a number of variables such as the severity of degeneration, the number of levels that are degenerated and the location of the degenerative disc. Thus it is important to understand how ASDD develops and progresses and how different variables that cause ASDD compare with reference to normal disc biomechanics. It is proposed to address this clinically relevant problem using poroelastic finite element models.

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Munoz, Hector E., Jianhua Yao, Joseph E. Burns, Yasuyuki Pham, James Stieger, and Ronald M. Summers. "Vertebral degenerative disc disease severity evaluation using random forest classification." In SPIE Medical Imaging, edited by Stephen Aylward and Lubomir M. Hadjiiski. SPIE, 2014. http://dx.doi.org/10.1117/12.2042793.

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Ruberté, Lissette M., Raghu Natarajan, and Gunnar B. J. Andersson. "Biomechanical Effect of Lumbar Disc Degeneration Under Flexion/Extension: A Finite Element Model Study." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176190.

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Degenerative disc disease (DDD) is a progressive pathological condition observed in 60 to 80% of the population [1]. It involves changes in both the biochemistry and morphology of the intervertebral disc and is associated with chronic low back pain, sciatica and adult scoliosis [2,3]. The most accepted theory of the effects of DDD on the kinematics of the spine is that proposed by Kirkaldy-Willis and Farfan which states that the condition initiates as a temporary dysfunction, followed by instability and then re-stabilization as the disease progresses [4]. Although there is no clear relationship between disc degeneration and the mechanical behavior of the lumbar spine, abnormal motion patterns either in the form of increased motion or erratic motion have been reported from studies on human cadaveric motion segments [5,6]. To date however no study has looked at how disc degeneration affects the adjacent segment mechanics. IN vivo testing is difficult for these purposes given that specimens are generally obtained from people at the later stages of life and consequently often display multiple pathologies. A finite element model is a viable alternative to study the mechanics of the segments adjacent to the diseased disc. It is hypothesized that moderate degeneration at one level will alter the kinematics of the whole lumbar spine.

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Cochran, Joseph, Jamie L. Baisden, Narayan Yoganandan, and Frank A. Pintar. "Effects of Treatment for Cervical Disc Degenerative Disease in Military Populations." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-63919.

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Numerous clinical and biomechanical evaluations of cervical disc replacement and anterior cervical discectomy and fusion as treatment of cervical disc herniation have been performed. Military patients represent a unique patient population as they may be subject to large external forces in theatre. Military patients are more susceptible to degenerative disease of the cervical spine, and if treated with single-level bony fusion, the treated level may be subject to large forces postoperatively. Literature reviews were conducted to determine patient outcomes following cervical disc replacement compared to bony fusion surgery; compare cadaver studies that evaluated the two conditions; and finite element modeling studies. In the civilian population, patients treated with each type of surgery have clinical improvement that is at least equivalent in the 2- and 5-year follow-up periods. Based on the finite element and cadaver biomechanical studies, semiconstrained devices, ProDisc-C and Prestige, are less mobile and a larger load is placed on the core of the device in comparison to the more mobile and unconstrained Bryan disc.

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Muñoz, Hector E., Jianhua Yao, Joseph E. Burns, and Ronald M. Summers. "Detection of vertebral degenerative disc disease based on cortical shell unwrapping." In SPIE Medical Imaging, edited by Carol L. Novak and Stephen Aylward. SPIE, 2013. http://dx.doi.org/10.1117/12.2008063.

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Anderst, William J., Thomas P. Lacek, William F. Donaldson, Joon Y. Lee, and James D. Kang. "Cervical Disc Height During Dynamic In Vivo Flexion-Extension." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53154.

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Cervical disc degeneration is a common and potentially debilitating disease. Over 100,000 surgical procedures are performed per year in the US to treat degenerative cervical spines1. However, the in vivo kinematics and arthrokinematics of the cervical spine have yet to be adequately characterized due to the inability to precisely track vertebral movement during dynamic motion. We have recently established the validity of a set of tools, including a biplane x-ray system, a model-based tracking technique and custom software, to precisely measure in vivo cervical spine kinematics and arthrokinematics with sub-millimeter accuracy2. Consequently, we can now begin to investigate the interdependent relationship between cervical vertebral kinematics and disc morphology and mechanical properties.

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