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Dissertations / Theses on the topic 'Degradation metabolites'

Author: Grafiati

Published: 10 August 2024

Last updated: 31 July 2025

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1

Nalli, Sandro. "Biological degradation of plasticizers and their metabolites." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85630.

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Plasticizers are widely used as additives for the production of PVC and other types of plastics. They have been observed to leach out of the solid matrix over the course of the lifetime of the finished product. These compounds have now been observed across the globe and in different environments. The main focus of this work is the study of the interactions of industrial plasticizers with soil microorganisms including bacteria, yeast and fungi.<br>This research is concerned with the microbial degradation of plasticizers such as di-2-ethylhexyl phthalate (DEHP) and di-2-ethylhexyl adipate

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Horn, Owen. "Environmental Contamination by Metabolites of Microbial Degradation of Plasticizers." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92140.

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Earlier work with pure cultures has shown that the interaction of microbes with plasticizers leads to the formation ofmetabolites including 2-ethylhexanol and 2ethylhexanoic acid that resist further degradation. The same studies have shown that these compounds exhibit acute toxicity. This work has shown that the ability of soil micro-organisms to produce these metabolites from the degradation ofplasticizers is a general phenomenon. It was also found that the ability of soil organisms to degrade 2ethylhexanoic acid does not seem to be as common. Taken together, it would be expected that partial

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3

Long, Sarah Ann. "Studies of fungal natural products and the degradation of A- and SS-trenbolone." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1356.

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4

Edwards, Michael. "Biological activity of anthocyanins and their phenolic degradation products and metabolites in human vascular endothelial cells." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/50546/.

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Human, animal, and in vitro data indicate significant vasoprotective activity of anthocyanins. However, few studies have investigated the activity of anthocyanin degradation products and metabolites which are likely to mediate bioactivity in vivo. The present thesis therefore examined the vascular bioactivity in vitro of anthocyanins, their phenolic degradants, and the potential for interactions between dietary bioactive compounds. Seven treatment compounds (cyanidin-, peonidin-, petunidin- & malvidin-3-glucoside, and protocatechuic, vanillic, and syringic acid) and two treatment combinations

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5

Afsarmanesh, Tehrani Rouzbeh. "AEROBIC BACTERIAL DEGRADATION OF HYDROXYLATED PCBs: POTENTIAL IMPLICATIONS FOR NATURAL ATTENUATION OF PCBs." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216532.

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Civil Engineering<br>Ph.D.<br>Polychlorinated biphenyls (PCBs) are toxic and persistent chemicals that have been largely dispersed into the environment. The biological and abiotic transformations of PCBs often generate hydroxylated derivatives, which have been detected in a variety of environmental samples, including animal tissues and feces, water, and sediments. Because of their toxicity and widespread dispersion in the environment, hydroxylated PCBs (OH-PCBs) are today increasingly considered as a new class of environmental contaminants. Although PCBs are known to be susceptible to microbia

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6

Mardal, Marie [Verfasser]. "Studies on the biotransformation/degradation pathways of drugs of abuse and their main human metabolites in wastewater / Marie Mardal." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1227925484/34.

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7

CANAVESI, ROSSANA. "Chemical and metabolic stability studies of propargylamine-containing drugs." Doctoral thesis, Università del Piemonte Orientale, 2016. http://hdl.handle.net/11579/115197.

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8

McClean, Stephen. "An investigation of modern analytical techniques for the identification and determination of selected drugs and pollutants, their degradation products and metabolites." Thesis, University of Ulster, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322413.

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9

Lentola, Andrea. "Systemic insecticides, their degradation products and metabolites in the environment. Quantification methodologies in environmental samples relevant for toxicological and ecotoxicological studies." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427171.

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Systemic insecticides are widely used for pests control and their success is due to their ability of protect the whole plant from roots to the upper leaf. In particular, seeds coating technique is very popular and it is applied to many crops (e.g. corn). However, the use of high amount of Active Ingridient (AI) for seeds coating is causing concern about negative effects to non-target animals. Pollinators insects are exposed to contaminated pollen and nectar, but also herbivore insects are exposed through contaminated leaf. In addition, these insecticides can leach from fields and contaminate

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10

Minetto, Luciane. "Antibióticos macrolídeos: determinação e identificação de metabólitos e subprodutos de degradação em efluente hospitalar." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/4262.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Macrolide antibiotics are an important group of prescription drugs; as a consequence of the large and continuous use, they are commonly found in the environment. In the present study, it was developed and optimized a chromatographic method to assess the occurrence of macrolide antibiotics Azithromycin, Clarithromycin, Erythromycin and Roxithromycin in the effluent of the University Hospital of Santa Maria, in two sampling points, by applying high performance liquid chromatography coupled to mass detection with quadrupole ion trap

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11

Ryan, Brendan J. "The microbial degradation of the DDT metabolite dichlorobenzophenone (DBP)." Thesis, University of Canterbury. Microbiology, 1995. http://hdl.handle.net/10092/8554.

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Soil samples which had been previously exposed to chlorinated aromatics were screened for ability to degrade dichlorobenzophenone (DBP). Of the samples tested soil from the Dow Elanco Agricultural Farm and soil from the AgResearch Winchmore Research Station showed apparent degradative capabilities. Degradation was not sustainable in these soil samples and a time scale study showed DBP was stable in soil over a 24 week period. Samples from Winchmore were further used to establish enrichment cultures capable of degrading DBP and its non-chlorinated analogue benzophenone (BP) through selection pr

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12

Hong, Junting. "Evaluation of atrazine degradation processes in water by electrical discharges and high-frequency ultrasound : parametric optimization and study of reaction mechanisms." Electronic Thesis or Diss., Compiègne, 2024. http://www.theses.fr/2024COMP2804.

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L'objectif principal de la thèse est de développer une technologie efficace pour la dégradation des pesticides. L'herbicide atrazine a été étudié comme molécule modèle. L'atrazine a été dégradée dans l'eau par décharge électrique de haute tension (DEHT), et ses performances de dégradation ont été comparées aux technologies traditionnelles d'oxydation de Fenton et d'ultrasons (US). La détection et la quantification de l'atrazine et de ses métabolites ont été réalisées par chromatographie liquide haute performance et spectrométrie de masse à haute résolution (HPLC-HRMS). Une méthode d'analyse en

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13

Asano, Lisa. "Vitamin D metabolite, 25-Hydroxyvitamin D, regulates lipid metabolism by inducing degradation of SREBP/SCAP." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225512.

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14

Schmidt, Oliver [Verfasser], and Harold [Akademischer Betreuer] Drake. "Hydrogen Metabolizers : Drivers of Anaerobic Degradation Processes in Peatlands and Earthworm Guts / Oliver Schmidt. Betreuer: Harold Drake." Bayreuth : Universität Bayreuth, 2016. http://d-nb.info/1113107286/34.

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15

LE, CAM BRUNO, and Jean Boucaud. "Degradation des parois vegetales et interactions metaboliques lors de l'infection parasitaire de daucus carota par mycocentrospora acerina, agent pathogene de conservation." Caen, 1994. http://www.theses.fr/1994CAEN2023.

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Mycocentrospora acerina est le principal agent pathogene de la carotte (daucus carota l. ) conservee au froid humide; ce travail decrit le processus infectieux d'isolats plus ou moins agressifs sur des cultivars de sensibilite differentes. L'objectif de cette etude, focalisee sur les composantes de l'agressivite du parasite et des defenses constitutives et induites de la plante, est de mieux comprendre la nature des echanges moleculaires s'etablissant lors de l'infection, afin de proposer des axes de recherches pour lutter contre ce nouveau probleme parasitaire. L'etude sur l'agressivite du ch

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16

JACQUES, NATHALIE. "L'efficacite de traduction d'arnm hybrides lacz d'e. Coli est couplee a leur synthese et a leur degradation, et est modulee par les conditions metaboliques." Paris 7, 1992. http://www.theses.fr/1992PA077090.

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Pour examiner l'influence possible des conditions de croissance sur la traduction des arnm de e. Coli et l'existence eventuelle d'un couplage entre traduction et degradation et entre traduction et synthese des arnm, nous avons construit une collection de genes chimeriques lamb-lacz et gale-lacz ne differant entre eux que par des mutations ponctuelles affectant l'efficacite de traduction. Nos resultats indiquent que selon l'efficacite de traduction des arnm hybrides lacz, il se produit soit un couplage entre traduction et synthese, soit un couplage entre traduction et degradation dans lequel l'

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17

Scherr, Frank. "Sorption, degradation and transport of estrogens and estrogen sulphates in agricultural soils." Diss., Lincoln University, 2009. http://hdl.handle.net/10182/1017.

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The fate and behaviour of estrogens in the environment are of concern due to the compounds’ endocrine disruption potential. Estrogens, namely 17β-estradiol (E2), estrone (E1), and estrogen sulphates, i.e. 17β-estradiol-3-sulphate (E2-3S) and estrone-3-sulphate (E1-3S) excreted by livestock constitute a potential source for estrogen contamination in the environment. A method was developed to separate and quantify the hormones by high-performance-liquid-chromatography (HPLC) and ultraviolet detection (UV). A combination of dichloromethane (DCM) and dicyclohexylamine hydrochloride (DCH·HCl) gave

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18

Reinnicke, Sandra [Verfasser], Rainer [Akademischer Betreuer] Meckenstock, and Andreas [Akademischer Betreuer] Rossmann. "Compound specific isotope analysis of the pesticides bentazone, MCPA, dichlobenil and its main metabolite BAM: Method validation and degradation studies / Sandra Reinnicke. Gutachter: Rainer Meckenstock ; Andreas Rossmann. Betreuer: Rainer Meckenstock." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1016741898/34.

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19

Sarrazin, Luc. "Etude de la biodegradation de molécules organiques tensio-actives (alkylbenzenesulfonates linéaires) en milieu aquatique littoral." Aix-Marseille 1, 1997. http://www.theses.fr/1997AIX11001.

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Les agents tensio-actifs de synthese constituent, a cause de leur large diffusion, une forme de pollution preoccupante atteignant tout le milieu naturel. Ce memoire vise a completer les donnees concernant le devenir, dans differents compartiments du milieu aquatique (eau, sediment), d'une variete de produits tensio-actifs tres utilises actuellement: les alkylbenzenesulfonates lineaires (las). Dans la premiere partie de cette etude sont presentees les connaissances existantes a propos des agents-tensio actifs et plus particulierement les las. Par la suite sont detaillees les diverses etapes de

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20

Arellano, Michel. "Cardiotoxicité du 5-fluorouracile, médicament antitumoral majeur : mise en cause de la formulation et de la métabolisation." Toulouse 3, 1995. http://www.theses.fr/1995TOU30228.

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Le 5-fluorouracile (fu) est un des medicaments anticancereux les plus utilises dans le monde. Comme tous les cytostatiques, il presente des effets secondaires toxiques, en particulier hematologiques et digestifs, mais aussi neurologiques et cardiologiques. La cardiotoxicite observee chez certains patients traites au fu est en partie due a la presence d'impuretes fluorees presentes dans les solutions commerciales de fu. Ces impuretes sont en fait des produits de degradation du fu qui se forment avec le temps dans le milieu basique indispensable a la solubilisation de ce principe actif. Grace au

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21

Cheng, Yung-Ling, and 曾勇霖. "Degradation of algal metabolites using heterogeneous catalytic ozonation processes." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/40938813107284423373.

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碩士<br>弘光科技大學<br>環境工程研究所<br>95<br>Abstract Ozone, due its high oxidation and disinfection potential, has recently received much attention in water treatment technology. Despite several advantages of using ozone, it has a few disadvantages, which limit its application in water treatment technology. The main are relatively low solubility and stability in water. Because of both the high cost of ozone production and only partial oxidation of organic compounds present in water, the application of ozonation might not be feasible from an economic point of view. The objective of this study was to e

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22

Bamuza-Pemu, Emomotimi Emily. "Photocatalytic degradation of phenolic compounds and algal metabolites in water." Thesis, 2014. http://hdl.handle.net/2263/40191.

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Algal infestation in water bodies causes the release of soluble organic compounds that impact negatively on the taste and odour of the water. With increasing pollution in water bodies and increasing nutrient loading from agricultural activities, most water reservoirs in South Africa and around the world have become affected by this problem. In this study, an advanced oxidation process (AOP), namely, photocatalysis was evaluated for its potential to degrade aromatic compounds; and taste and odour causing bi-cyclic compounds originating from algae. Semiconductor photocatalysis is an envir

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23

KathleenLansigan and 賴宣琳. "Degradation and Metabolites of Microcystis aeruginosa during Ozonation: Kinetic Study." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/67232453882146799884.

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碩士<br>國立成功大學<br>環境工程學系碩博士班<br>100<br>The occurrence of cyanobacteria or blue-green algae in drinking water systems is potentially harmful for human health. Among the common problems associated with it include the production of toxins and undesirable taste and odor (T＆O). One of the most common toxin-producer among cyanobacteria is Microcystisaeruginosa. This species is capable of producing microcystins, a group of cyanotoxins which exhibit chronic effects on humans and wildlife by damaging the liver. Microcystis blooms can also produce β-cyclocitral, a malodor that gives a hay-tobacco odor.Oxi

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24

Fortin, Pascal. "Degradation of polychlorinated biphenyl (PCB) metabolites : directed evolution and enzymatic fortuity." Thesis, 2005. http://hdl.handle.net/2429/17659.

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A multi-faceted approach was used to investigate and overcome the PCB-degrading limitations of the Bph enzymes, responsible for the catabolism of biphenyl. First, the reactivities of four evolutionarily divergent extradiol dioxygenases towards mono-, di- and trichlorinated 2,3-dihydroxybiphenyls (DHBs) were investigated: 2,3-dihydroxybiphenyl dioxygenase (EC 1.13.11.39) from Burkholderia xenovorans sp. LB400 (DHBD[sub LB400]), DHBD[sub P6]-I and DHBD[sub P6]-III from Rhodococcus globerulus P6 and 2,2',3-trihydroxybiphenyl dioxygenase from Sphingomonas sp. RW1 (THBD[sub RW1]). The specificity o

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黃郁智. "Chemical analysis of metabolites associated with the microbiological degradation of PCBs." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/46823540646038866182.

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Kuo, Yi-Hsin, and 郭宜鑫. "The Effect of Chlorine Dioxide on Nitrofuran Metabolites Degradation in Water and Sediments." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/2d5ak4.

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碩士<br>國立臺灣海洋大學<br>水產養殖學系<br>103<br>The objective of this study was to investigate the effect of different concentrations of chlorine dioxide (ClO2) on degradation of four nitrofuran metabolites (AOZ, AMOZ, SC and AH) in freshwater and seawater environments of water and sediments; also to understand the situation of nitrofuran metabolites residues in water and sediments. Experiment consisted of four parts, first was to establish the method for detecting the four nitrofuran metabolites in water and sediments, and the results showed that specificity, recovery, repeatability and limits of quantifi

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Pao, Yu-Jie (Bao Yu-Jie), and 包宇潔. "The Effect of Escherichia Coli Laccase (CueO) on TNT Microbial Degradation and Metabolites Biotoxicity." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/493grf.

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碩士<br>國立高雄師範大學<br>生物科技系<br>106<br>2, 4, 6-Trinitrotoluene, the yellow-colored solid, is a useful explosive dynamite best known as TNT and massive utilized for military and industry. After widely used, it caused environmental pollution both for soil and groundwater contaminated. The influence of repopulation is difficult and expensive to remedy. In addition, the literature indicates that human exposure to TNT waste will stand a high probability of getting anemia and liver dysfunction. TNT and related metabolites also listed as carcinogens, for a reason that TNT contamination of remediation is a

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28

Chin, Yu-Kai, and 金煜凱. "The degradation of vinclozolin metabolites and its toxicity on water flea and soil microbial populations." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/75222512572993395070.

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碩士<br>國立臺灣大學<br>農業化學研究所<br>98<br>Dicarboximide fungicide vinclozolin was found to have the anti-androgen effects, and its metabolites, M1 (2-[[(3,5-dichlorophenyl)-carbamoyl]oxy]-2-methyl-3-butenoic acid) and M2 (3’,5’-dichloro-2-hydroxy-2-methylbut-3-enanilide), were found to have more affinity to androgen receptors than vinclozoline. In this study, the effect of vinclozolin metabolites in soil on its persistence and soil microbial populations diversity were investigated. The toxicity of vinclozolin on Daphnia pulex, were compared with 2 kinds of its metabolites. First, we extract vinclozolin

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LaRao and 饒拉. "Effect of Chlorination on the Cell Integrity and Metabolites Release and Degradation for Colonial Microcystis." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/84761414370561194959.

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碩士<br>國立成功大學<br>環境工程學系碩博士班<br>101<br>The proliferation of cyanobacteria in drinking water sources is problematic for water authorities as they can interfere with water treatment processes. Chlorination as a commonly used oxidation process in water treatment has shown the potential to lyse cyanobacterial cells, resulting in release of toxic metabolites and odorants. Unfortunately, the netabolites are sometimes difficult to be removed in conventional water treatment processes. Microcystis, a toxic genus of cyanobacteria often present in colonial forms under natural conditions is studied for the

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Zhen, Lin. "Effects of filtration sterilization on the stability of ketamine, selected benzodiazepines and metabolites in female urine." Thesis, 2017. https://hdl.handle.net/2144/20791.

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Benzodiazepines (Benzos) and ketamine (K) are compounds that have been encountered in Drug-Facilitated Sexual Assault (DFSA) cases. Due to the intimate nature of these crimes, evidence collection is often postponed due to delays and/or reluctance in reporting these crimes. Further delays in analysis may be encountered in laboratories with large caseloads and/or backlogs. Drug identification in biological samples is important to determine whether victims knowingly or unknowingly took an impairing substance, however, the results could be negative due to chemical degradation over a long storag

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Hsieh, Hsiao-Cheng, and 謝孝正. "Pseudomonas putida TX2:a novel bacterial strain in the degradation of octylphenol polyethoxylates and their metabolites with estrogenic activity." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/13446018087722517452.

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碩士<br>國立中央大學<br>生命科學研究所<br>92<br>Alkylphenol polyethoxylates (APEOn), one kind of non-ionic surfactants, was extensively used in the industrial, agricultural and household activities. These compounds were frequently discharged into natural environment and transformed to alkylphenol (AP) and APEOn (n=1-2), which was more recalcitrant and has been demonstrated as the environmental hormone with estrogenic-like activity to aquatic organisms, wildlife and humans. Only a few of microorganism that can degrade alkylphenol polyethoxylates or alkylphenol were isolated. The biodegradation pathway of thes

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32

KELTNEROVÁ, Lucie. "Degradation of atrazine by homogeneous photocatalysis using Fe(III)/UV/air system and evaluation of potential toxicity of atrazine and its metabolites." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-262720.

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Atrazine photochemical degradation in homogeneous phase using Fe(III)/UV/air system was studied. Two toxicity assessments, a Lemna minor growth inhibition test and a Daphnia magna acute immobilisation test, were employed to test potential toxicity of atrazine and its degradation products. The occurrence of atrazine in rivers from the Vltava River basin was evaluated from the analyses performed by Povodí Vltavy, State Enterprise.

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(9755756), Rachel Coleman. "Exploration of 20S Proteasome Stimulation as a Therapeutic Approach to Parkinson's Disease." Thesis, 2020.

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<p>Parkinson’s disease (PD) is a detrimental neurodegenerative disorder characterized by the presence of large protein aggregates in the brain called Lewy bodies, which are primarily composed of the protein α-synuclein (αSyn). Due to the dysregulation of αSyn levels in PD, controlling its levels through the manipulation of protein degradation pathways has been suggested as a therapeutic avenue for the treatment of PD and related diseases. Although αSyn is known to be degraded through the autophagy and proteasome pathways, it is one of only a few known substrates of the ubiquitin-independent pr

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Kim, Myung Hee 1982. "Factors Affecting Biodefluorination of Fluorotelomer Alcohols (FTOHs): Degradative Microorganisms, Transformation Metabolites and Pathways, and Effects of Co-substrates." Thesis, 2012. http://hdl.handle.net/1969.1/148234.

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Fluorotelomer alcohols (FTOHs, F(CF2)nCH2CH2OH) are emerging contaminants in the environment. Biodegradation of 6:2 and 8:2 FTOHs has been intensively studied using soils and activated sludge. However, little is known about the bacteria responsible for biotransformation of FTOHs. This study deciphered factors affecting biodefluorination of FTOHs and their metabolites, and developed three effective FTOH-degrading consortia. Two alkane-degrading Pseudomonas strains (P. oleovorans and P. butanovora) can defluorinate 4:2, 6:2 and 8:2 FTOHs, with a higher degree of defluorination for 4:2 FTOH.

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Palma, Tânia Cristina da Luz. "Degradation studies of widely used pharmaceutical compounds by heterogeneous photocatalysis and bacterial communities and isolates." Doctoral thesis, 2020. http://hdl.handle.net/10400.1/15227.

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The present thesis was focused on degradation studies of five extensively and globally used pharmaceutical compounds: chloramphenicol, paracetamol, fluoxetine and 17α-ethynilestradiol which are considered emerging pollutants that enter in the environment due to its inefficient removal by the conventional wastewater treatments plants. Photodegradation and biodegradation assays were realized. The photodegradation of chloramphenicol and paracetamol was successfully performed by heterogeneous photocatalysis using PbS/TiO2 nanocomposites, as catalysts, which were synthesized using biological sulphi

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Käseberg, Thomas. "Antibiotics in urban waters." 2019. https://tud.qucosa.de/id/qucosa%3A72526.

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The discovery of antibiotics is considered as one of the most significant scientific achievements of the 20th century – lives of millions of people and animals have been saved. Thenceforth, substantial amounts of administered antibiotics and their metabo-lites have been excreted into waste stream via urine and faeces. In this dissertation, primary focus is the qualitative balance of 14 antibiotics and one metabolite in urban water management and in urban waters, respectively. In particular, antibiotics pre-scribed to human beings are drained in the urban sewer system and finally enter the envi

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