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Journal articles on the topic 'Degranulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Dvorak, A. M., R. A. Monahan-Earley, H. F. Dvorak, and S. J. Galli. "Ultrastructural cytochemical and autoradiographic demonstration of nonspecific esterase(s) in guinea pig basophils." Journal of Histochemistry & Cytochemistry 35, no. 3 (1987): 351–60. http://dx.doi.org/10.1177/35.3.3819377.

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We used ultrastructural autoradiographic and cytochemical methods to localize esterase activities in unstimulated guinea pig basophils and in basophils undergoing degranulation or recovery from degranulation. We used tritium-labeled diisopropylfluorophosphate (DFP) as a probe for serine enzymes and localized this probe by ultrastructural autoradiography to cytoplasmic granules of immature or mature unstimulated basophils, as well as to granules released by degranulating basophils. Ultrastructural cytochemistry using alpha naphthyl acetate (ANA) as substrate localized nonspecific esterase activ

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Gan, Xiaoliang, Dandan Xing, Guangjie Su, et al. "Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/167014.

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Both oxidative stress and mast cell (MC) degranulation participate in the process of small intestinal ischemia reperfusion (IIR) injury, and oxidative stress induces MC degranulation. Propofol, an anesthetic with antioxidant property, can attenuate IIR injury. We postulated that propofol can protect against IIR injury by inhibiting oxidative stress subsequent from NADPH oxidase mediated MC activation. Cultured RBL-2H3 cells were pretreated with antioxidant N-acetylcysteine (NAC) or propofol and subjected to hydrogen peroxide (H2O2) stimulation without or with MC degranulator compound 48/80 (CP

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3

Li, Wen-Wu, Tian-Zhi Guo, De-yong Liang, Yuan Sun, Wade S. Kingery, and J. David Clark. "Substance P Signaling Controls Mast Cell Activation, Degranulation, and Nociceptive Sensitization in a Rat Fracture Model of Complex Regional Pain Syndrome." Anesthesiology 116, no. 4 (2012): 882–95. http://dx.doi.org/10.1097/aln.0b013e31824bb303.

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Background Patients with complex regional pain syndrome have increased tryptase in the skin of the affected extremity indicating mast cell (MC) accumulation and degranulation, processes known to be mediated by substance P (SP). The dysregulation of SP release from primary afferent neurons is characteristic of complex regional pain syndrome. The authors hypothesized that SP acting through the neurokinin-1 receptor results in mast cell accumulation, degranulation, and nociceptive sensitization in a rat model of complex regional pain syndrome. Methods Groups of 6-10 rats underwent tibia fracture

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4

Marshall, J. S., R. H. Stead, C. McSharry, L. Nielsen, and J. Bienenstock. "The role of mast cell degranulation products in mast cell hyperplasia. I. Mechanism of action of nerve growth factor." Journal of Immunology 144, no. 5 (1990): 1886–92. http://dx.doi.org/10.4049/jimmunol.144.5.1886.

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Abstract A variety of mast cell degranulating agents have previously been shown to induce mast cell hyperplasia in adult rats. In neonates 2.5 S nerve growth factor (NGF) induces a hyperplasia of both mucosal and connective tissue mast cells (MMC and CTMC). We have examined the role of the potent mast cell degranulating properties of NGF on its ability to induce mast cell hyperplasia. Administration of NGF in combination with the mast cell stabilizing agent disodium cromoglycate was found to abrogate the CTMC hyperplasia induced by NGF alone. Treatment of neonatal rats with the alternate degra

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5

Bhakta, Suhani B., Stefan M. Lundgren, Bethany N. Sesti, et al. "Neutrophil-like cells derived from the HL-60 cell-line as a genetically-tractable model for neutrophil degranulation." PLOS ONE 19, no. 2 (2024): e0297758. http://dx.doi.org/10.1371/journal.pone.0297758.

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Research on neutrophil biology has been limited by the short life span and limited genetic manipulability of these cells, driving the need for representative and efficient model cell lines. The promyelocytic cell line HL-60 and its subline PLB-985 can be differentiated into neutrophil-like cells (NLCs) and have been used to study neutrophil functions including chemotaxis, phagocytosis, endocytosis, and degranulation. Compared to neutrophils derived from hematopoietic stem cells, NLCs serve as a cost-effective neutrophil model. NLCs derived from both HL-60 and PLB-985 cells have been shown to p

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Kilinc, E., Y. Dagistan, B. Kotan, and A. Cetinkaya. "Effects of Nigella sativa seeds and certain species of fungi extracts on number and activation of dural mast cells in rats." Physiology International 104, no. 1 (2017): 15–24. http://dx.doi.org/10.1556/2060.104.2017.1.8.

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In this study, we aimed to investigate the effects of Nigella sativa seeds and certain species of fungi extracts on the number and degranulation states of dural mast cells in rats. Rats were fed ad libitum with normal tap water or tap water with extract of N. sativa seed, Ramaria condensata, Lactarius salmonicolor, Lactarius piperatus, and Tricholoma terreum for 3 days. Mast cells in dura mater were counted and evaluated in terms of granulation and degranulation states. Compound 48/80, a mast cell degranulating agent, and T. terreum significantly increased the percent of degranulated mast cell

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Antymys, O. V., О. Y. Zhurakivska, V. A. Міskiv, U. M. Dutchak, and N. T. Sahan. "MORPHOFUNCTIONAL STUDY OF TISSUE BASOPHILS ACTIVITY WITH GENERAL DEEP HYPOTHERMIA." INTERNATIONAL MEDICAL HERALD 1, no. 1(1) (2025): 6–10. https://doi.org/10.64108/imh.2025.1.1.6.

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Abstract. The absence of a complex morphofunctional approach to the study of tissue basophils when exposed to cold factors has not allowed for the revelation of many aspects of the pathogenesis of changes in this influence. Therefore, the purpose of this study was to establish the morpho-functional state of tissue basophils of different layers of skin with general deep hypothermia. Immediately after cold exposure, a massive degranulation of tissue basophils, especially those located directly near the wall of vessels, is noted. The most pronounced changes we have noted from the third day of the

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8

Baehner, Robert L., and Morris J. Karnovsky. "Degranulation deconstructed." Journal of Clinical Investigation 122, no. 5 (2012): 1596–97. http://dx.doi.org/10.1172/jci62990.

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9

Solomkin, Joseph S. "Degranulation Inhibition." Archives of Surgery 121, no. 1 (1986): 77. http://dx.doi.org/10.1001/archsurg.1986.01400010083011.

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10

Bansal, Geetanjali, Zhihui Xie, and Kirk Druey. "Rgs13 inhibits IgE-mediated allergic responses (37.5)." Journal of Immunology 178, no. 1_Supplement (2007): S19. http://dx.doi.org/10.4049/jimmunol.178.supp.37.5.

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Abstract Mast cells (MCs) evoke immediate hypersensitivity by degranulating in response to antigen (Ag) exposure and releasing preformed mediators such as histamine and leukotreines. Classically, the high affinity immune receptor for immunoglobulin E (FcεRI) mediates MC degranulation and anaphylaxis in response to antigen. In addition, various G protein coupled receptors (GPCRs) on MCs such as those for adenosine and sphingosine-1-phosphate (S1P) may also activate MCs. Since GPCR signaling is inhibited by Regulator of G protein Signaling (RGS) proteins, we studied the potential regulation of M

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11

Kaur, Gunjanpreet, Nirmal Singh, and Amteshwar Singh Jaggi. "Mast cells in neuropathic pain: an increasing spectrum of their involvement in pathophysiology." Reviews in the Neurosciences 28, no. 7 (2017): 759–66. http://dx.doi.org/10.1515/revneuro-2017-0007.

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AbstractMast cells are immunological cells that are diversely distributed in different parts of the body. Their role in various pathological conditions such as hypersensitivity, atherosclerosis, pulmonary hypertension, and male infertility has been reported by different scientists. Apart from these, a number of studies have shown their important role in pathogenesis of neuropathic pain of diverse aetiology. They have been found to release active mediators, primarily histamine and serotonin on degranulation in response to different stimuli including chemical, nerve damage, toxin or disease-rela

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Abe, Nozomu, Hiroaki Toyama, Yutaka Ejima та ін. "α1-Adrenergic Receptor Blockade by Prazosin Synergistically Stabilizes Rat Peritoneal Mast Cells". BioMed Research International 2020 (13 травня 2020): 1–12. http://dx.doi.org/10.1155/2020/3214186.

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Background. Adrenaline quickly inhibits the release of histamine from mast cells. Besides β2-adrenergic receptors, several in vitro studies also indicate the involvement of α-adrenergic receptors in the process of exocytosis. Since exocytosis in mast cells can be detected electrophysiologically by the changes in the membrane capacitance (Cm), its continuous monitoring in the presence of drugs would determine their mast cell-stabilizing properties. Methods. Employing the whole-cell patch-clamp technique in rat peritoneal mast cells, we examined the effects of adrenaline on the degranulation of

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Caruso, Rosario, Valerio Caruso, and Luciana Rigoli. "Ultrastructural Evidence of Interactions Between Eosinophils and Mast Cells in Gastric Cancer: Considerations in AllergoOncology Research." Gastrointestinal Disorders 7, no. 3 (2025): 41. https://doi.org/10.3390/gidisord7030041.

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Background/Objectives: AllergoOncology is a new field of study that investigates the relationship between allergic inflammation and cancer. Mast cells and eosinophils are two critical players in allergy reactions, where they can interact and release bioactive granules. The electron microscope is an indispensable tool for analyzing membrane contacts and degranulation patterns in mast cells and eosinophils. The aim of the present ultrastructural study is to analyze the interactions between tumor-associated eosinophils and mast cells (TATEM) in nine cases of gastric cancer. Methods: Seventy-two g

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14

Huang, Yuyou, Fangfang Li, Zhongyun Chen, et al. "Predictive Value of Degranulating Factors of Neutrophils in Massive Cerebral Infarction." Cell Transplantation 30 (January 1, 2021): 096368972110040. http://dx.doi.org/10.1177/09636897211004089.

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Massive cerebral infarction (MCI) is a life-threatening disease and may lead to cerebral herniation. Neutrophil degranulation contributes to ischemic injury in the early stage. To investigate whether neutrophil degranulating factors can predict cerebral herniation and the long-term prognosis of patients with MCI and to investigate the relationship between neutrophil degranulation and blood brain barrier (BBB) damage. In this case-control study of 14 MCI patients, we divided the patients into a cerebral hernia group and no cerebral hernia group according to whether they developed cerebral herni

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15

Kazama, Itsuro, Hiroyuki Sonobe, and Junko Shida. "Magnesium and Zinc Dose-Dependently Stabilize Rat Peritoneal Mast Cells and Enhance the Effects of Adrenaline." Cellular Physiology and Biochemistry 59, no. 4 (2025): 465–77. https://doi.org/10.33594/000000793.

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Background/Aims: Magnesium and zinc are vital trace elements found in numerous foods and dietary supplements. In addition to their antioxidant, anticancer, antibacterial, and anti-inflammatory effects, clinical research has suggested that they possess anti-allergic properties. Methods: Using differential-interference contrast (DIC) microscopy, we examined the effects of magnesium chloride (MgCl2) and zinc chloride (ZnCl2) on rat peritoneal mast cell degranulation. We also examined their effects in conjunction with adrenaline, the first-choice drug for anaphylaxis treatment. Results: Both MgCl2

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Levy, Dan, Shahaf Edut, Renana Baraz-Goldstein, et al. "Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache." Cephalalgia 36, no. 10 (2016): 915–23. http://dx.doi.org/10.1177/0333102415617412.

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Background Chronic post-traumatic headache (PTH) is one of the most common symptoms of mild traumatic brain injury (mTBI) but its underlying mechanisms remain unknown. Inflammatory degranulation of dural mast cells (MCs) is thought to promote headache, and may play a role in PTH. Whether mTBI is associated with persistent degranulation of dural MCs is yet to be determined. Methods Histochemistry was used to evaluate time course changes in dural MC density and degranulation level in concussive head trauma and blast mouse models of mTBI. The effects of sumatriptan and the MC stabilizer cromolyn

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17

Hadjaj, B., Y. Cherruault, and J. Sainte Laudy. "Basophil degranulation control." International Journal of Bio-Medical Computing 31, no. 2 (1992): 89–97. http://dx.doi.org/10.1016/0020-7101(92)90065-z.

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18

Kannan, Subburaj. "Neutrophil degranulation: therapeutic targets in [NTP]O mediated neutrophil degranulation." Medical Hypotheses 63, no. 2 (2004): 325–27. http://dx.doi.org/10.1016/j.mehy.2002.05.001.

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19

Anikeeva, Nadia, Maria Steblyanko, Leticia Kuri-Cervantes, Marcus Buggert, Michael R. Betts, and Yuri Sykulev. "Functional anomaly of CD8 T cells at earlier differentiation stages during HIV infection as established by analysis of synaptic interface and degranulation pattern." Journal of Immunology 204, no. 1_Supplement (2020): 86.46. http://dx.doi.org/10.4049/jimmunol.204.supp.86.46.

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Abstract It is thought that HIV infection could lead to a global defect in CD8+ T cell function. However, the effect of the infection on CD8+ T cells at various stages of differentiation has not been well studied. To evaluate the functional activity of CD8+ T cells from HIV infected people at various differentiation stages, we assessed their ability to form synaptic interfaces using planar lipid bilayers containing anti-CD3 antibody and soluble ICAM-1 ligand. We analyzed the dynamics of the T cell/bilayer interface formation, size of adhesion area, and kinetics of T-cell degranulation, paramet

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20

Budnevskiy, A. V., S. N. Avdeev, E. S. Ovsyannikov, et al. "Certain Aspects of Mast Cell Carboxypeptidase A3 Involvement in the Pathogenesis of COVID-19." Tuberculosis and Lung Diseases 102, no. 1 (2024): 26–33. http://dx.doi.org/10.58838/2075-1230-2024-102-1-26-33.

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The objective: to determine the involvement of lung mast cell carboxypeptidase A3 (SPA3) in the pathogenesis of COVID-19. Subjects and Methods. Samples of autopsy specimens from the lungs of patients who died of severe COVID-19 and patients who died of external causes were examined. On day 2 after the patient's death, the autopsy was performed and autopsy specimens were collected. Histological samples were prepared to analyze the degranulation activity of CPA3-positive mast cells (MCs). Correlations between protease profile and clinical and laboratory parameters were analyzed.Results. In the p

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Mendoza, Ryan P., Colin C. Anderson, James R. Roede, and Jared M. Brown. "Comparing mast cell immunometabolism shifts induced by IgE mediated and non-IgE mediated degranulation." Journal of Immunology 202, no. 1_Supplement (2019): 54.14. http://dx.doi.org/10.4049/jimmunol.202.supp.54.14.

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Abstract Mast cells are immune effector cells with the ability to immediately release an array of pre-formed mediators in response to various stimuli, a process termed degranulation. Degranulation is generally divided into two categories: IgE mediated and non-IgE mediated. Non-IgE mast cell degranulation occurs in response to various environmental agents without prior IgE sensitization often making it difficult to identify the causative agent in patients. To better understand non-IgE mast cell degranulation, we characterized and compared metabolic shifts in response to both mechanisms of degra

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22

Kurimoto, Y., A. L. de Weck, and C. A. Dahinden. "Interleukin 3-dependent mediator release in basophils triggered by C5a." Journal of Experimental Medicine 170, no. 2 (1989): 467–79. http://dx.doi.org/10.1084/jem.170.2.467.

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The anaphylatoxin C5a is a potent trigger for basophil degranulations, but in contrast to IgE-dependent basophil activation, it does not result in the synthesis of sulfidoleukotrienes (leukotriene C4/D4/E4). Thus, degranulation and the generation of lipid mediators are separately regulated cellular responses. Exposure of human blood basophils to the cytokine IL-3 alone does not induce the release of histamine in cells from most donors and never leads to the generation of LTC4, indicating that IL-3 is not a direct agonist for basophil mediator release. However, preincubation of basophils with I

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23

Andreone, Sara, Francesca Spadaro, Carla Buccione, et al. "IL-33 Promotes CD11b/CD18-Mediated Adhesion of Eosinophils to Cancer Cells and Synapse-Polarized Degranulation Leading to Tumor Cell Killing." Cancers 11, no. 11 (2019): 1664. http://dx.doi.org/10.3390/cancers11111664.

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Eosinophils are major effectors of Th2-related pathologies, frequently found infiltrating several human cancers. We recently showed that eosinophils play an essential role in anti-tumor responses mediated by immunotherapy with the ‘alarmin’ intereukin-33 (IL-33) in melanoma mouse models. Here, we analyzed the mechanisms by which IL-33 mediates tumor infiltration and antitumor activities of eosinophils. We show that IL-33 recruits eosinophils indirectly, via stimulation of tumor cell-derived chemokines, while it activates eosinophils directly, up-regulating CD69, the adhesion molecules ICAM-1 a

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O'Flaherty, J. T., and J. Nishihira. "Arachidonate metabolites, platelet-activating factor, and the mobilization of protein kinase C in human polymorphonuclear neutrophils." Journal of Immunology 138, no. 6 (1987): 1889–95. http://dx.doi.org/10.4049/jimmunol.138.6.1889.

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Abstract In contrast to our previous report (Biochem. Biophys. Res. Comm. 134:587, 1986), we now find that protein kinase C (PKC) is mobilized in human polymorphonuclear neutrophils (PMN) stimulated with platelet-activating factor (PAF) or leukotriene (LT)B4. Thus nanomolar concentrations of each compound caused PMN to lose cytosolic, PKC-specific protein phosphorylating activity, as well as receptors for phorbol myristate acetate (PMA). Smaller gains in membrane-associated PMA receptors accompanied these changes. Diacylglycerol and PMA had very similar effects on PKC. However, unlike these di

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Gwalani, Lavesh A., and Jordan S. Orange. "Four-dimensional correlation between frequency of degranulation and Natural Killer (NK) cell cytotoxicity." Journal of Immunology 198, no. 1_Supplement (2017): 138.5. http://dx.doi.org/10.4049/jimmunol.198.supp.138.5.

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Abstract NK cells are cytotoxic lymphocytes required for early control of viral infections and tumor immunosurveillance. NK cytotoxicity occurs through directed secretion of lytic granules (LG) containing effector molecules such as perforin and granzymes. Cytoskeletal reorganization during the formation of an NK-cell immunological synapse (IS) enables delivery of LG to the IS. Fusion of LG with the NK cell membrane results in exocytosis of its contents into the IS leading to target cell death. While the requirements for LG transport and exocytosis are largely known, the minimum number of degra

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Oka, Tatsuya, Masatoshi Hori, Akane Tanaka, Hiroshi Matsuda, Hideaki Karaki, and Hiroshi Ozaki. "IgE alone-induced actin assembly modifies calcium signaling and degranulation in RBL-2H3 mast cells." American Journal of Physiology-Cell Physiology 286, no. 2 (2004): C256—C263. http://dx.doi.org/10.1152/ajpcell.00197.2003.

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In the mast cell signaling pathways, the binding of immunoglobulin E (IgE) to FcϵRI, its high-affinity receptor, is generally thought to be a passive step. In this study, we examined the effect of IgE alone, that is, without antigen stimulation, on the degranulation in mast cells. Monomeric IgE (500–5,000 ng/ml) alone increased cytosolic Ca2+ level ([Ca2+]i) and induced degranulation in rat basophilic leukemia (RBL)-2H3 mast cells. Monomeric IgE (5,000 ng/ml) alone also increased [Ca2+]i and induced degranulation in bone marrow-derived mast cells. Interestingly, monomeric IgE (5–50 ng/ml) alon

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Bryceson, Yenan T., Daniela Pende, Andrea Maul-Pavicic, et al. "A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes." Blood 119, no. 12 (2012): 2754–63. http://dx.doi.org/10.1182/blood-2011-08-374199.

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Abstract Familial hemophagocytic lymphohistiocytosis (FHL) is a life-threatening disorder of immune regulation caused by defects in lymphocyte cytotoxicity. Rapid differentiation of primary, genetic forms from secondary forms of hemophagocytic lymphohistiocytosis (HLH) is crucial for treatment decisions. We prospectively evaluated the performance of degranulation assays based on surface up-regulation of CD107a on natural killer (NK) cells and cytotoxic T lymphocytes in a cohort of 494 patients referred for evaluation for suspected HLH. Seventy-five of 77 patients (97%) with FHL3-5 and 11 of 13

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Sakuma, Megumi, Yasuhito Shirai, Ken-ichi Yoshino та ін. "Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release". Molecular Biology of the Cell 23, № 18 (2012): 3707–21. http://dx.doi.org/10.1091/mbc.e12-01-0053.

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Using specific inhibitors, kinase-negative mutants, and small interfering RNA against protein kinase Cα (PKCα) or PKCβI, we find that PKCβI positively regulates degranulation in rat basophilic leukemia–2H3 cells, whereas PKCα negatively regulates degranulation. Mass spectrometric and mutagenic analyses reveal that PKCα phosphorylates cofilin at Ser-23 and/or Ser-24 during degranulation. Overexpression of a nonphosphorylatable form (S23,24A), but not that of a mutant-mimicking phosphorylated form (S23,24E), increases degranulation. Furthermore, the S23,24A mutant binds to F-actin and retains it

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Kinlough-Rathbone, R. L., D. W. Perry, M. A. Guccione, M. L. Rand, and M. A. Packham. "Degranulation of Human Platelets by the Thrombin Receptor Peptide SFLLRN: Comparison with Degranulation by Thrombin." Thrombosis and Haemostasis 70, no. 06 (1993): 1019–23. http://dx.doi.org/10.1055/s-0038-1649718.

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SummaryA new, simplified method of degranulating human platelets using the thrombin receptor peptide SFLLRN (20 |iM) is described; released fibrinogen cannot be converted to fibrin, and the platelets are not exposed to a proteolytic enzyme, as they are when thrombin is used for degranulation. The peptide-degranulated platelets regain their disc shape and are recovered as single platelets which have released approximately 90% of the contents of their dense granules. Their procoagulant activity is greater than that of control platelets, but somewhat less than that of thrombin-degranulated platel

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Chieffi Baccari, Gabriella, Sara Falvo, Antonia Lanni, Maria Maddalena Di Fiore, Federica Cioffi, and Alessandra Santillo. "Mast Cell Population and Histamine Content in Hypothyroid Rat Tissues." Animals 12, no. 14 (2022): 1840. http://dx.doi.org/10.3390/ani12141840.

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The morphological features and relative number of mast cells (MCs) were studied in the skin and exorbital lacrimal glands of hypothyroid Wistar rats, Rattus norvegicus. Hypothyroidism significantly increased the number of MCs (up to 4.5-fold) and histamine content (up to 50%) in the examined tissues. The magnitude of the increase in the number of MCs was greater in the cheek skin and exorbital lacrimal glands than in the back skin. In the skin, the MCs were mainly located within the hypodermis and closely associated with the blood vessels, nerve fascicles, and adipocytes. In the exorbital lacr

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Horie, S., and H. Kita. "CD11b/CD18 (Mac-1) is required for degranulation of human eosinophils induced by human recombinant granulocyte-macrophage colony-stimulating factor and platelet-activating factor." Journal of Immunology 152, no. 11 (1994): 5457–67. http://dx.doi.org/10.4049/jimmunol.152.11.5457.

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Abstract Recent evidence suggests adhesion molecules play an important role in the function of leukocytes. Because human eosinophils are known to express beta 2 integrins, we hypothesized that these adhesion molecules mediate the effector function of eosinophils. Normal human eosinophils incubated in albumin-coated polystyrene plates released granule protein and produced superoxide anion when stimulated with human recombinant granulocyte-macrophage CSF (rGM-CSF), platelet-activating factor (PAF), or PMA. Simultaneous monitoring of eosinophil adhesion and degranulation showed that degranulation

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Tuma, Rabiya S. "The degranulation two-step." Journal of Cell Biology 170, no. 1 (2005): 9. http://dx.doi.org/10.1083/jcb1701iti5.

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Hadjaj, B., Y. Cherruault, and J. Sainte Laudy. "Control of basophil degranulation." International Journal of Bio-Medical Computing 32, no. 2 (1993): 151–59. http://dx.doi.org/10.1016/0020-7101(93)90053-9.

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OHASHI, HIROSHI, MASAHARU ISHIKAWA, JUNKO ITO, et al. "Sulochrin Inhibits Eosinophil Degranulation." Journal of Antibiotics 50, no. 11 (1997): 972–74. http://dx.doi.org/10.7164/antibiotics.50.972.

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Grigorieva, D. V., I. V. Gorudko, A. V. Sokolov, et al. "Myeloperoxidase Stimulates Neutrophil Degranulation." Bulletin of Experimental Biology and Medicine 161, no. 4 (2016): 495–500. http://dx.doi.org/10.1007/s10517-016-3446-7.

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Abu-Ghazaleh, R. I., T. Fujisawa, J. Mestecky, R. A. Kyle, and G. J. Gleich. "IgA-induced eosinophil degranulation." Journal of Immunology 142, no. 7 (1989): 2393–400. http://dx.doi.org/10.4049/jimmunol.142.7.2393.

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Abstract Eosinophils play an important role as effector cells in allergic, parasitic, and other conditions. The mechanism(s) by which eosinophils mediate their effector functions was studied by incubation of human normodense eosinophils with Sepharose beads coupled to various Ig isotypes as targets. Controls included eosinophils incubated alone or incubated with uncoated beads, human serum albumin-, or OVA-coated beads. An eosinophil granule protein, the eosinophil-derived neurotoxin (EDN), was measured as an indicator of eosinophil degranulation. Eosinophils released eosinophil-derived neurot

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Michael John Dochniak and Cherie Annette Benson. "Allergo oncology: Targeted degranulation." Open Access Research Journal of Science and Technology 8, no. 1 (2023): 011–13. http://dx.doi.org/10.53022/oarjst.2023.8.1.0026.

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Allergies are an inevitable part of life, no matter where we live. Without a doubt, the symptoms of allergies can cause severe physical and mental suffering. Although medical science has made great strides in suppressing allergy symptoms with medicines, immunotherapies, and virus-like particle technology (i.e., Allergy Vaccines), research indicates that allergies may be nature's cancer immunotherapy. Targeted degranulation explores breaking the immune-tolerance cancer barrier. This review will discuss how IgE-primed effector cells and allergenic vaccines may inhibit solid tumor progression.

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Fettrelet, Timothée, Lea Gigon, Alexander Karaulov, Shida Yousefi, and Hans-Uwe Simon. "The Enigma of Eosinophil Degranulation." International Journal of Molecular Sciences 22, no. 13 (2021): 7091. http://dx.doi.org/10.3390/ijms22137091.

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Eosinophils are specialized white blood cells, which are involved in the pathology of diverse allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as cytotoxic effector cells but have been suggested to additionally play a role in immunomodulation and maintenance of homeostasis. The exact role of these granule-containing leukocytes in health and diseases is still a matter of debate. Degranulation is one of the key effector functions of eosinophils in response to diverse stimuli. The different degranulation patterns occurring in eosinophils (piecemeal degranulation

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Cervantes Villagrana, Rodolfo, Silvia Cruz та Claudia González Espinosa. "Anandamide inhibits FcϵRI-dependent degranulation through a mechanism involving receptor-operated, but not store-operated calcium entry in mast cells (151.7)". Journal of Immunology 186, № 1_Supplement (2011): 151.7. http://dx.doi.org/10.4049/jimmunol.186.supp.151.7.

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Abstract IgE/Antigen-mediated crosslinking of the high affinity IgE receptor (FcϵRI) in mast cells leads to the release of preformed, granule-stored mediators in a calcium-dependent process known as anaphylactic degranulation. Inhibition of degranulation has been proposed for the control of allergic reactions. Cannabinoid (CB) receptors have been recently found to modulate distinct immune responses. The aim of this work was to analyze the effects of the CB agonist anandamide (AEA) on the anaphylactic degranulation triggered by FcϵRI activation in murine bone marrow-derived mast cells. AEA inhi

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Armengot, Miguel, Luis Garín, and Carmen Carda. "Eosinophil Degranulation Patterns in Nasal Polyposis: An Ultrastructural Study." American Journal of Rhinology & Allergy 23, no. 5 (2009): 466–70. http://dx.doi.org/10.2500/ajra.2009.23.3357.

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Background Eosinophils are possibly the most important inflammatory cells in the pathogenesis of rhinosinusitis with nasal polyposis. Eosinophil degranulation is the mechanism by which these cells exert their inflammatory action. Knowledge of eosinophil state and degranulation mode therefore may help us to better understand this disease. A study is made of eosinophil state and degranulation mode using transmission electron microscopy (TEM), attempting to establish correlations with certain clinical variables considered to be of importance in patients with nasal polyposis. Methods A prospective

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Pedersen, Sara Hougaard, Roshni Ramachandran, Dipak Vasantrao Amrutkar, Steffen Petersen, Jes Olesen, and Inger Jansen-Olesen. "Mechanisms of glyceryl trinitrate provoked mast cell degranulation." Cephalalgia 35, no. 14 (2015): 1287–97. http://dx.doi.org/10.1177/0333102415574846.

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Background Migraine patients develop attacks several hours after intravenous infusion of glyceryl trinitrate. Due to the short half-life of nitric oxide, this delayed migraine cannot be caused by a direct action of nitric oxide derived from glyceryl trinitrate. The involvement of meningeal inflammation and dural mast cell degranulation is supported by the effectiveness of prednisolone on glyceryl trinitrate-induced delayed headache. Methods Using a newly developed rat model mimicking the human glyceryl trinitrate headache model, we have investigated the occurrence of dural mast cell degranulat

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Mendoza, Ryan P., Colin C. Anderson, James R. Roede, and Jared M. Brown. "Potential role of thioredoxin-interacting protein in non-IgE mast cell degranulation." Journal of Immunology 204, no. 1_Supplement (2020): 148.27. http://dx.doi.org/10.4049/jimmunol.204.supp.148.27.

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Abstract Non-IgE mediated pathways of mast cell degranulation result in similar pathological outcomes as IgE mediated degranulation without prior IgE sensitization thereby making it difficult to identify causative agents and develop therapeutics for patients. We have demonstrated that 20 nm silver nanoparticles (AgNP) induce non-IgE mast cell degranulation through an unknown mechanism. However, we have established that this non-IgE response is strain dependent with C57BL/6 bone marrow derived mast cells (BMMCs) being high responders and LP/J BMMCs being low responders. Further, RNA sequencing

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Murugin, Vladimir V., Irina N. Zuikova, Nina E. Murugina, Andrey E. Shulzhenko, Boris V. Pinegin, and Mikhail V. Pashenkov. "Reduced Degranulation of NK Cells in Patients with Frequently Recurring Herpes." Clinical and Vaccine Immunology 18, no. 9 (2011): 1410–15. http://dx.doi.org/10.1128/cvi.05084-11.

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ABSTRACTNK cells lyse virus-infected cells by degranulation; however, alterations in NK cell degranulation in persistent viral infections have not been directly studied. Earlier reports have documented a decrease in NK activity in patients with frequently recurring herpes (FRH). We corroborate these findings by showing that the degranulation responses of blood NK cells from patients with FRH, both during relapse and during remission, are significantly lower than those in healthy donors. The impaired degranulation was probably not caused by defective target cell recognition, since it was observ

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Yamasaki, Sho, Eri Ishikawa, Masayuki Kohno та Takashi Saito. "The quantity and duration of FcRγ signals determine mast cell degranulation and survival". Blood 103, № 8 (2004): 3093–101. http://dx.doi.org/10.1182/blood-2003-08-2944.

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Abstract Immunoglobulin E (IgE) bound to multivalent antigen (Ag) elicits mast cell degranulation but not survival; on the contrary, IgE in the absence of Ag (IgE(-Ag)) induces survival only but not degranulation. Although these distinct responses are mediated through the same receptor, FcϵRI, the molecular mechanism generating the divergence is largely unknown. We recently showed that the signals through FcRγ chain are essential for IgE(-Ag)–induced mast cell survival as well as IgE(+Ag)–induced degranulation. To determine whether the cellular output is regulated by the quantity of FcRγ signa

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Choi, Kyoung-seong, Dennis J. Grab, and J. Stephen Dumler. "Anaplasma phagocytophilum Infection Induces Protracted Neutrophil Degranulation." Infection and Immunity 72, no. 6 (2004): 3680–83. http://dx.doi.org/10.1128/iai.72.6.3680-3683.2004.

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ABSTRACT Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

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Maharani, Intan, Cahya Yustisia Hasan, Bambang Dwirahardjo, and Tri Wahyu Pangestiningsih. "Effect of low-intensity pulsed ultrasound on mast cell degranulation and fibroblast expression on type 2 diabetes mellitus rats wound healing process." Majalah Kedokteran Gigi Indonesia 7, no. 2 (2022): 60. http://dx.doi.org/10.22146/majkedgiind.59132.

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Impaired wound healing is one of the Diabetes mellitus complications. Low-intensity Pulsed Ultrasound (LIPUS) therapy may accelerate the impaired wound healing. The use of LIPUS therapy in the early inflammatory phase can induce mast cell degranulation, and in the proliferative phase it can increase collagen synthesis by fibroblasts. The purpose of this study was to determine the effects of LIPUS therapy on mast cell degranulation and fibroblastexpression in the healing process of punch biopsy wound in rats with type 2 diabetes mellitus. Twenty-four Sprague dawley (n=24) were designed into typ

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Golden, H. W., G. L. Crean, D. A. Iacuzio, and I. G. Otterness. "Effect of disodium cromoglycate on cutaneous basophil anaphylaxis." Journal of Immunology 137, no. 5 (1986): 1495–503. http://dx.doi.org/10.4049/jimmunol.137.5.1495.

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Abstract Cutaneous basophil anaphylaxis (CBA) was elicited by intradermal rechallenge of cutaneous basophil hypersensitivity (CBH) sites in guinea pigs sensitized 7 days previously with keyhole limpet hemocyanin (KLH). The antiallergy agent disodium cromoglycate (DSCG), administered i.v. immediately before rechallenge, inhibited the increased vasopermeability (measured by tissue dye uptake) and basophil degranulation (measured by light microscopic counts of intact basophils) characteristic of the CBA reaction. The antihistamine mepyramine, administered orally, inhibited vasopermeability but no

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Misawa, Ryosuke, Kazuhito Takemoto, Masaki Iji, Hao Luo, Akari Koresawa та Hiroyuki Watanabe. "Utility of mast cell P815 for evaluating FcεRI-dependent and FcεRI-independent allergic effects". Allergologia et Immunopathologia 52, № 4 (2025): 119–27. https://doi.org/10.15586/aei.v53i4.1264.

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Introduction and Objectives: The degranulation and release of inflammatory mediators mediated by the high-affinity immunoglobulin E (IgE) receptor (FcεRI) on mast cells in response to allergen contact is the driving force of anaphylaxis. This study shows that P815 cells, which were previously thought not to express FcεRI, cause a reaction similar to FcεRI-mediated degranulation in the presence of antigen and IgE.Materials and Methods: The kinetics of degranulation were evaluated by comparing P815 cells with FcεRI-expressing a rat basophilic leukemia (RBL-2H3) (that typically indicates the spec

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Bryceson, Yenan T., Michael E. March, Domingo F. Barber, Hans-Gustaf Ljunggren, and Eric O. Long. "Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells." Journal of Experimental Medicine 202, no. 7 (2005): 1001–12. http://dx.doi.org/10.1084/jem.20051143.

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The relative contribution to cytotoxicity of each of the multiple NK cell activation receptors has been difficult to assess. Using Drosophila insect cells, which express ligands of human NK cell receptors, we show that target cell lysis by resting NK cells is controlled by different receptor signals for cytolytic granule polarization and degranulation. Intercellular adhesion molecule (ICAM)-1 on insect cells was sufficient to induce polarization of granules, but not degranulation, in resting NK cells. Conversely, engagement of the Fc receptor CD16 by rabbit IgG on insect cells induced degranul

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Takeyama, Kiyoshi, Carlos Agustí, Iris Ueki, James Lausier, Lars Olaf Cardell, and Jay A. Nadel. "Neutrophil-dependent goblet cell degranulation: role of membrane-bound elastase and adhesion molecules." American Journal of Physiology-Lung Cellular and Molecular Physiology 275, no. 2 (1998): L294—L302. http://dx.doi.org/10.1152/ajplung.1998.275.2.l294.

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We examined the effect of the neutrophil chemoattractants interleukin (IL)-8 and N-formyl-methionyl-leucyl-phenylalanine on goblet cell (GC) degranulation in guinea pigs. Chemoattractants caused time-dependent neutrophil recruitment and GC degranulation in vivo. NPC 15669 (an inhibitor of leukocyte infiltration) prevented both responses, implicating neutrophils. ICI 200,355 (an inhibitor of neutrophil elastase and proteinase-3) or secretory leukocyte protease inhibitor (an inhibitor of elastase but not of proteinase-3) abolished IL-8-induced GC degranulation, implicating elastase. Incubating t

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