Log in

Relevant bibliographies by topics / Delayed-rational model / Journal articles

To see the other types of publications on this topic, follow the link: Delayed-rational model.

Journal articles on the topic 'Delayed-rational model'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Delayed-rational model.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Alter, David M., and Tsu-Chin Tsao. "Two-Dimensional Exact Model Matching With Application to Repetitive Control." Journal of Dynamic Systems, Measurement, and Control 116, no. 1 (1994): 2–9. http://dx.doi.org/10.1115/1.2900677.

Full text

Abstract:

This paper concerns matching a system with time-delayed feedback to a rational transfer function model and its application to repetitive controller design. Necessary and sufficient conditions on the order of the plant, reference model, and controller are obtained for the existence of causal and stabilizing exact model matching solutions. The results are applied to robust repetitive controller design, in which a delayed feedback is introduced in the repetitive controller for rejecting periodic disturbances while simultaneously achieving input-output model matching. Furthermore, the 2-D model ma

APA, Harvard, Vancouver, ISO, and other styles

2

Al-Hdaibat, Bashir, and A. Alameer. "Bifurcation and Chaos in a Nonlinear Population Model with Delayed Nonlinear Interactions." Mathematics 13, no. 13 (2025): 2132. https://doi.org/10.3390/math13132132.

Full text

Abstract:

This paper investigates the dynamic behavior of a second-order nonlinear rational difference equation modeling a population system with nonlinear interactions between current and previous population states. We derive analytical conditions for the stability of fixed points, explore codim-1 bifurcations, and compute the associated topological normal forms. The analysis also establishes the existence of period-2 solutions and reveals the potential for chaotic dynamics within specific parameter ranges. To validate the theoretical findings, we conduct numerical simulations and bifurcation analysis

APA, Harvard, Vancouver, ISO, and other styles

3

Clatch, Lauren, and Eugene Borgida. "Behavioral Economics in Plea-Bargain Decision-Making: Beyond the Shadow-of-Trial Model." Review of Law & Economics 17, no. 2 (2021): 349–83. http://dx.doi.org/10.1515/rle-2021-0069.

Full text

Abstract:

Abstract Legal scholars have long assumed that plea bargains are contracts negotiated between rational actors who adhere to the dictates of the normative shadow-of-trial model. The two key features that rational actors presumably haggle over in the shadow of trial are the criminal charge (and associated sentence) and the probability of trial conviction. The behavioral economics theory of discounting, however, offers a theoretical foundation for testing the shadow-of-trial model. This article summarizes findings from experimental discounting studies in behavioral economics and psychological sci

APA, Harvard, Vancouver, ISO, and other styles

4

Zhang, Zili, Jing Chen, and Yawen Mao. "Ridge regression and lasso regression based least squares algorithm for a time-delayed rational model via redundant rule." International Journal of Modelling, Identification and Control 40, no. 1 (2022): 11. http://dx.doi.org/10.1504/ijmic.2022.124075.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Zhang, Zili, Jing Chen, and Yawen Mao. "Ridge regression and lasso regression based least squares algorithm for a time-delayed rational model via redundant rule." International Journal of Modelling, Identification and Control 40, no. 1 (2022): 11. http://dx.doi.org/10.1504/ijmic.2022.10048798.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Brokof, Philipp, Guillaume J. J. Fournier, and Wolfgang Polifke. "Linear time-continuous state-space realization of flame transfer functions by means of a propagation equation." INTER-NOISE and NOISE-CON Congress and Conference Proceedings 265, no. 4 (2023): 3490–501. http://dx.doi.org/10.3397/in_2022_0496.

Full text

Abstract:

Low-order network models, commonly used to assess the thermo-acoustic stability of combustors, can be cast in a linear, time-continuous state-space representation. A standard linear eigenvalue problem for the system modes results, which can be solved in a robust and efficient manner. To represent the linear dynamics of any time-invariant flame in the state-space framework, this study presents an approximation of the distributed time-delayed flame response to acoustic velocity perturbations based on a spatially discretized propagation equation (PE). We derive the rational flame transfer functio

APA, Harvard, Vancouver, ISO, and other styles

7

Ma, Junhai, and Hongliang Tu. "Complexity of a Duopoly Game in the Electricity Market with Delayed Bounded Rationality." Discrete Dynamics in Nature and Society 2012 (2012): 1–13. http://dx.doi.org/10.1155/2012/698270.

Full text

Abstract:

According to a triopoly game model in the electricity market with bounded rational players, a new Cournot duopoly game model with delayed bounded rationality is established. The model is closer to the reality of the electricity market and worth spreading in oligopoly. By using the theory of bifurcations of dynamical systems, local stable region of Nash equilibrium point is obtained. Its complex dynamics is demonstrated by means of the largest Lyapunov exponent, bifurcation diagrams, phase portraits, and fractal dimensions. Since the output adjustment speed parameters are varied, the stability

APA, Harvard, Vancouver, ISO, and other styles

8

Sun, Yuancheng, and Zhanhong Liang. "Fault Diagnosis and Fault Tolerant Control for Non-Gaussian Singular Time-Delayed Stochastic Distribution Systems with Disturbance Based on the Rational Square-Root Model." Journal of Control Science and Engineering 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/9563481.

Full text

Abstract:

For the non-Gaussian singular time-delayed stochastic distribution control (SDC) system with unknown external disturbance where the output probability density function (PDF) is approximated by the rational square-root B-spline basis function, a robust fault diagnosis and fault tolerant control algorithm is presented. A full-order observer is constructed to estimate the exogenous disturbance and an adaptive observer is used to estimate the fault size. A fault tolerant tracking controller is designed using the feedback of distribution tracking error, fault, and disturbance estimation to let the

APA, Harvard, Vancouver, ISO, and other styles

9

Prokhorchenko, Andrii, Dmytro Gurin, Iryna Lahuta, and Viktoriia Sunytska. "IMPROVEMENT OF THE PROCEDURE FOR SEARCHING RATIONAL TIME RESERVES FOR RECOVERY OF TRAIN MOVEMENT OF DIFFERENT CATEGORIES." Collected scientific works of Ukrainian State University of Railway Transport, no. 193 (October 5, 2021): 44–53. http://dx.doi.org/10.18664/1994-7852.193.2020.229812.

Full text

Abstract:

This article improves the procedure for finding rational time reserves for theresumption of trains of different categories depending on the number of detained trains on the basisof the epidemiological SIR-model. A modified epidemiological SIR-model has been implemented forthe experimental railway line, which allows to take into account the interaction of trains of differentpriorities in the train schedule and the possibility of resumption of delayed trains due to the set timereserve. The adjustment of the delay rate transfer coefficients on the real data of train delays at theline has been per

APA, Harvard, Vancouver, ISO, and other styles

10

Sidenev, D. M., S. A. Savelyev, A. R. Valieva, A. R. Gaysina, and R. G. Khasanov. "Improving the Efficiency of the Heat Exchange Network of the Delayed Coking Plant." Chemistry and Technology of Fuels and Oils 631, no. 3 (2022): 22–26. http://dx.doi.org/10.32935/0023-1169-2022-631-3-22-26.

Full text

Abstract:

Thermal integration of technological processes of oil refining is the most effective tool in the design and reconstruction of existing industrial facilities. The rational use of the heat of internal flows is especially important for energy-intensive processes of processing heavy oil residues, such as delayed coking. In this article, a model of the existing heat exchange network of the coke production process was constructed, for which a pinch analysis was carried out and the energy saving potential was determined. The analysis also revealed violations of the basic pinch rules made during the d

APA, Harvard, Vancouver, ISO, and other styles

11

Jackson, Mary, Susan W. Phalen, Micheline Lagranderie, et al. "Persistence and Protective Efficacy of aMycobacterium tuberculosis Auxotroph Vaccine." Infection and Immunity 67, no. 6 (1999): 2867–73. http://dx.doi.org/10.1128/iai.67.6.2867-2873.1999.

Full text

Abstract:

ABSTRACT New vaccines against tuberculosis are urgently required because of the impressive incidence of this disease worldwide and the highly variable protective efficacy of the current vaccine. The possibility of creating new live vaccines by the rational attenuation of strains from the Mycobacterium tuberculosis complex was investigated. Two auxotrophic mutants of M. tuberculosis and M. bovis BCG were constructed by disruption of one of their purine biosynthetic genes. These mutants appeared unable to multiply in vitro within mouse bone-marrow derived macrophages. They were also attenuated i

APA, Harvard, Vancouver, ISO, and other styles

12

Amirudin, Amirudin, Jumadil Saputra, Teuku Afrizal, M. Latip, and Α. Tarmizi. "Investigating the COVID-19 Self-Isolation Policy and Its Impact on Socioeconomic of Vulnerable Groups: An application of Rational and Non-Rational Thinking Models." WSEAS TRANSACTIONS ON ENVIRONMENT AND DEVELOPMENT 17 (June 1, 2021): 604–13. http://dx.doi.org/10.37394/232015.2021.17.58.

Full text

Abstract:

The spread of the Corona Virus Disease (COVID-19) pandemic continues in impending world public health and bringing considerable human suffering. The present study investigates the vulnerable groups' reaction from informal sectors to the execution of the self-isolation policy of COVID-19 in Semarang City, Indonesia. This study is designed using a qualitative method with an ethnography approach. Using the binary opposition thinking pattern pioneered by Levi-Strauss, this study conducts the interview process with 25 informants in Semarang City. The data analysed using the response pattern of info

APA, Harvard, Vancouver, ISO, and other styles

13

Zybała, Andrzej. "Wokół kultury umysłowej w Polsce — jej źródła i przejawy." Kultura i Społeczeństwo 61, no. 4 (2017): 103–23. http://dx.doi.org/10.35757/kis.2017.61.4.6.

Full text

Abstract:

The author defines intellectual culture as a tendency to base decisions on objective analyses or the habit of investigating issues analytically. In the broader sense, intellectual culture may be considered to be the way the collective reacts to phenomena that appear in the real world. A high level of intellectual culture, in the author’s opinion, is shown by a modern form of thinking manifested in the ability to make use of abstracts and to take into account alternative systems of constructing opinions. On the basis of selected analyses of Polish scholars the author advances the hypothesis tha

APA, Harvard, Vancouver, ISO, and other styles

14

Liu, Mianfang, Shengwu Xiong, and Bixiang Li. "Dynamic route guidance strategy in a two-route pedestrian-vehicle mixed traffic flow system." International Journal of Modern Physics C 27, no. 09 (2016): 1650099. http://dx.doi.org/10.1142/s0129183116500996.

Full text

Abstract:

With the rapid development of transportation, traffic questions have become the major issue for social, economic and environmental aspects. Especially, during serious emergencies, it is very important to alleviate road traffic congestion and improve the efficiency of evacuation to reduce casualties, and addressing these problems has been a major task for the agencies responsible in recent decades. Advanced road guidance strategies have been developed for homogeneous traffic flows, or to reduce traffic congestion and enhance the road capacity in a symmetric two-route scenario. However, feedback

APA, Harvard, Vancouver, ISO, and other styles

15

Ipateva, Irina A. "Perishable inventory management in manufacturing during logistics disruptions." Russian Management Journal 21, no. 1 (2023): 39–65. http://dx.doi.org/10.21638/spbu18.2023.103.

Full text

Abstract:

Goal: to analyze the features of the perishable raw materials management at a manufacturing enterprise, determine the key factors affecting the inventory management efficiency and, in accordance with them, adapt the classical model for determining the optimal delivery batch. Methodology: an empirical study of the factors was carried out using a critical analysis of the scientific literature; model formalization was implemented using mathematical methods for modeling rational systems in accordance with the algorithm for formulating optimization models, converted for perishable raw materials. Fi

APA, Harvard, Vancouver, ISO, and other styles

16

Amirudin, Amirudin, Mariusz Urbański, Jumadil Saputra, et al. "The Impact of the COVID-19 Self-Isolation Policy on the Occupations of Vulnerable Groups." International Journal of Environmental Research and Public Health 18, no. 12 (2021): 6452. http://dx.doi.org/10.3390/ijerph18126452.

Full text

Abstract:

Today, the spread of the Coronavirus 2019 (COVID-19) pandemic continues to impact on world public health and bring about considerable human suffering partly due to government policies on reducing the spread. COVID-19 has significantly affected human health and it has impacted on the occupation of vulnerable groups such as tour guides, drivers and shop assistants. Of these, the present study aims to investigate the impact of the COVID-19 self-isolation policy on the occupation of vulnerable groups in Semarang City, Indonesia. To achieve this objective, this study uses a qualitative method with

APA, Harvard, Vancouver, ISO, and other styles

17

Sen, Monokesh K., Mohammed S. M. Almuslehi, Peter J. Shortland, David A. Mahns, and Jens R. Coorssen. "Proteomics of Multiple Sclerosis: Inherent Issues in Defining the Pathoetiology and Identifying (Early) Biomarkers." International Journal of Molecular Sciences 22, no. 14 (2021): 7377. http://dx.doi.org/10.3390/ijms22147377.

Full text

Abstract:

Multiple Sclerosis (MS) is a demyelinating disease of the human central nervous system having an unconfirmed pathoetiology. Although animal models are used to mimic the pathology and clinical symptoms, no single model successfully replicates the full complexity of MS from its initial clinical identification through disease progression. Most importantly, a lack of preclinical biomarkers is hampering the earliest possible diagnosis and treatment. Notably, the development of rationally targeted therapeutics enabling pre-emptive treatment to halt the disease is also delayed without such biomarkers

APA, Harvard, Vancouver, ISO, and other styles

18

Radenovic, Cedomir, Milomir Filipovic, Dragojlo Selakovic, et al. "The prestigious maize inbred lines with erect top leaves: The priority performance of the efficient photosynthetic model in breeding." Genetika 41, no. 1 (2009): 41–58. http://dx.doi.org/10.2298/gensr0901041r.

Full text

Abstract:

This study conforms the hypothesis that there are elite maize inbred lines with erect top leaves that have a property of an efficient photosynthetic model and that as such are successfully used in the processes of breeding in which the number of plants is increased per area unit (plant density). This proof was established by the application of non- invasive photosynthetic-fluorescence method suitable for the evaluation of the efficiency of the photosynthetic model. The obtained photosynthetic and fluorescence properties of observed prestigious maize inbred lines with the erect top leaves are b

APA, Harvard, Vancouver, ISO, and other styles

19

Radenovic, Cedomir, Milomir Filipovic, Milosav Babic, et al. "Actual prestigious properties of maize inbred lines: A good initial basis for the efficient development of new and yielding maize hybrids." Genetika 40, no. 2 (2008): 121–33. http://dx.doi.org/10.2298/gensr0802121r.

Full text

Abstract:

This study conforms our hypothesis that there are elite maize inbred lines, which can be considered actual and prestigious as they have not only a property of the water status and a greater grain dry down rate during the maturation period, but also a property of the efficient photosynthetic-fluorescence model that is successfully used in the contemporary processes of breeding, and thereby in the development of new and yielding maize hybrids. Presented results obtained on the dynamics of grain dry down during the maturation period and on photosynthetic-fluorescence parameters (temperature depen

APA, Harvard, Vancouver, ISO, and other styles

20

Schach, Sonja, Axel Lindner, and Daniel Alexander Braun. "Bounded rational decision-making models suggest capacity-limited concurrent motor planning in human posterior parietal and frontal cortex." PLOS Computational Biology 18, no. 10 (2022): e1010585. http://dx.doi.org/10.1371/journal.pcbi.1010585.

Full text

Abstract:

While traditional theories of sensorimotor processing have often assumed a serial decision-making pipeline, more recent approaches have suggested that multiple actions may be planned concurrently and vie for execution. Evidence for the latter almost exclusively stems from electrophysiological studies in posterior parietal and premotor cortex of monkeys. Here we study concurrent prospective motor planning in humans by recording functional magnetic resonance imaging (fMRI) during a delayed response task engaging movement sequences towards multiple potential targets. We find that also in human po

APA, Harvard, Vancouver, ISO, and other styles

21

Wempe, Michael Fitzpatrick. "New Insights into Ion Channels: Predicting hERG-Drug Interactions." International Journal of Molecular Sciences 23, no. 18 (2022): 10732. http://dx.doi.org/10.3390/ijms231810732.

Full text

Abstract:

Drug-induced long QT syndrome can be a very dangerous side effect of existing and developmental drugs. In this work, a model proposed two decades ago addressing the ion specificity of potassium channels is extended to the human ether-à-gogo gene (hERG). hERG encodes the protein that assembles into the potassium channel responsible for the delayed rectifier current in ventricular cardiac myocytes that is often targeted by drugs associated with QT prolongation. The predictive value of this model can guide a rational drug design decision early in the drug development process and enhance NCE (New

APA, Harvard, Vancouver, ISO, and other styles

22

Hasan, R. G. M., J. J. McGuirk, D. D. Apsley, and M. A. Leschziner. "A turbulence model study of separated 3D jet/afterbody flow." Aeronautical Journal 108, no. 1079 (2004): 1–14. http://dx.doi.org/10.1017/s0001924000004942.

Full text

Abstract:

Three-dimensional RANS calculations and comparisons with experimental data are presented for subsonic and transonic flow past a non-axisymmetric (rectangular) nozzle/afterbody typical of those found in fast-jet aircraft. The full details of the geometry have been modelled, and the flow domain includes the internal nozzle flow and the jet exhaust plume. The calculations relate to two free-stream Mach numbers of 0-6 and 0-94 and have been performed during the course of a collaborative research programme involving a number of UK universities and industrial organisations. The close interaction bet

APA, Harvard, Vancouver, ISO, and other styles

23

Xiao, Jianli, Hanli Xiao, Xinchang Zhang, and Xiang You. "Stability, Bifurcation, and Chaos Control of Two-Sided Market Competition." International Journal of Computer Games Technology 2022 (August 17, 2022): 1–10. http://dx.doi.org/10.1155/2022/6006450.

Full text

Abstract:

Benefitting from the popular uses of internet technologies, two-sided market has been playing an increasing prominent role in modern times. Users and developers can interact with each other through two-sided platforms. The two-sided market structure has been investigated profoundly. Through building a dynamics two-sided market model with bounded rational, stability conditions of the two-sided market competition system are presented. With the help of bifurcation diagram, Lyapunov exponent, and strange attractor, the stability of the two-sided market competition model is simulated. At last, we u

APA, Harvard, Vancouver, ISO, and other styles

24

Vallarola, Antonio, Massimo Tortarolo, Roberta De Gioia, et al. "A Novel HGF/SF Receptor (MET) Agonist Transiently Delays the Disease Progression in an Amyotrophic Lateral Sclerosis Mouse Model by Promoting Neuronal Survival and Dampening the Immune Dysregulation." International Journal of Molecular Sciences 21, no. 22 (2020): 8542. http://dx.doi.org/10.3390/ijms21228542.

Full text

Abstract:

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease with no effective treatment. The Hepatocyte Growth Factor/Scatter Factor (HGF/SF), through its receptor MET, is one of the most potent survival-promoting factors for motor neurons (MN) and is known as a modulator of immune cell function. We recently developed a novel recombinant MET agonist optimized for therapy, designated K1K1. K1K1 was ten times more potent than HGF/SF in preventing MN loss in an in vitro model of ALS. Treatments with K1K1 delayed the onset of muscular impairment and reduced MN loss and skeletal muscle

APA, Harvard, Vancouver, ISO, and other styles

25

Charlet, Anne, Max Kappenstein, Philip Keye, et al. "The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML." Leukemia 36, no. 3 (2021): 701–11. http://dx.doi.org/10.1038/s41375-021-01462-4.

Full text

Abstract:

AbstractFLT3-ITD is the most predominant mutation in AML being expressed in about one-third of AML patients and is associated with a poor prognosis. Efforts to better understand FLT3-ITD downstream signaling to possibly improve therapy response are needed. We have previously described FLT3-ITD-dependent phosphorylation of CSF2RB, the common receptor beta chain of IL-3, IL-5, and GM-CSF, and therefore examined its significance for FLT3-ITD-dependent oncogenic signaling and transformation. We discovered that FLT3-ITD directly binds to CSF2RB in AML cell lines and blasts isolated from AML patient

APA, Harvard, Vancouver, ISO, and other styles

26

Шинкарук, Оксана, та Ганна Андрієнко. "Сучасні погляди та практичний досвід побудови етапу безпосередньої підготовки до змагань спортсменок в складнокоординаційних видах спорту (на матеріалі черліденгу)". Актуальні проблеми фізичного виховання та методики спортивного тренування, № 3 (20 грудня 2024): 98–111. https://doi.org/10.31652/3041-2463/2024-3-8.

Full text

Abstract:

The preparation of athletes in complex coordination sports, such as cheerleading, requires the development and implementation of specialized training methods focused on enhancing physical, technical, tactical, and psychological skills. Modern approaches emphasize the need for a comprehensive and individualized approach that aligns with the specific demands of this sport, where team interaction and high coordination play a critical role. Purpose of the study: to analyze modern approaches and develop the final preparation stage for competitions in complex coordination sports, using cheerleading

APA, Harvard, Vancouver, ISO, and other styles

27

Garvey, Edward P., Andrew Sharp, Peter Warn, Christopher M. Yates, and Robert J. Schotzinger. "1346. The Tetrazole VT-1598 Is Efficacious in a Murine Model of Invasive Aspergillosis with a PK/PD Expected of a Mold-Active CYP51 Inhibitor." Open Forum Infectious Diseases 5, suppl_1 (2018): S411—S412. http://dx.doi.org/10.1093/ofid/ofy210.1177.

Full text

Abstract:

Abstract Background VT-1598 is a novel fungal CYP51 inhibitor with potent in vitro activity against yeast, mold, and endemic pathogenic fungi (Wiederhold, JAC, 2017). Its tetrazole-based rational drug design imparts much greater selectivity vs. human CYPs (Yates, BMCL, 2017), which could reduce human CYP-related side effects and DDIs. We report here VT-1598’s in vivo activity in an invasive aspergillosis (IA) model. Methods MIC was determined as outlined in CLSI M38-A2. Plasma PK was measured after 4 days of oral doses in neutropenic ICR mice without fungal inoculation. In vivo antifungal acti

APA, Harvard, Vancouver, ISO, and other styles

28

Schweber, Sarah J., Alicia G. Rodriguez-LaRocca, Valerie Calvert, et al. "Protein pathway activation mapping guided biomarker development to identify optimal combinations of MEK inhibitor with PI3K/mTOR pathway inhibitors for the treatment of triple-negative breast cancer." Journal of Clinical Oncology 31, no. 15_suppl (2013): 2612. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.2612.

Full text

Abstract:

2612 Background: Activated MAPK and PI3K pathway signaling are associated with poor prognosis in triple negative breast cancer (TNBC). Although some TNBC cell models are sensitive to MEK inhibition, feedback activation of the PI3K pathway mediates resistance. Thus, suppression of both arms of the MAPK/PI3K/mTOR network is a rational approach to targeting TNBC. Here we explore the anti-tumor efficacy of combinations of MEK inhibitor with PI3K, AKT, or mTOR inhibitors with a focus on biomarker development. Methods: Combinations of the MEK inhibitor PD-0325901 with the PI3K inhibitor GDC-0941, AK

APA, Harvard, Vancouver, ISO, and other styles

29

Ergin, Erdoğan. "Eğitim Siyasasının Yapılandırılması Formülasyonunda Karar Verme (Decision-Making) Modelleri." International Journal of Social Sciences 8, no. 33 (2024): 155–68. http://dx.doi.org/10.52096/usbd.8.33.11.

Full text

Abstract:

Abstract The decision-making process in education policy making begins with the raising of an education-related problem, which is often the first step towards the legislative process. In this regard, the decision-making process focuses on how the proposals included in the policy agenda will be implemented and with what strategies they can be implemented. Again, qualified information obtained from the policy analysis department can directly affect decision-making mechanisms. However, it is decided by adding cultural, social, economic and other dynamics of society in order to decide on the polic

APA, Harvard, Vancouver, ISO, and other styles

30

Singh, Renu, Michelle C. Swick, Kimberly R. Ledesma, et al. "Temporal Interplay between Efflux Pumps and Target Mutations in Development of Antibiotic Resistance in Escherichia coli." Antimicrobial Agents and Chemotherapy 56, no. 4 (2012): 1680–85. http://dx.doi.org/10.1128/aac.05693-11.

Full text

Abstract:

ABSTRACTThe emergence of resistance presents a debilitating change in the management of infectious diseases. Currently, the temporal relationship and interplay between various mechanisms of drug resistance are not well understood. A thorough understanding of the resistance development process is needed to facilitate rational design of countermeasure strategies. Using anin vitrohollow-fiber infection model that simulates human drug treatment, we examined the appearance of efflux pump (acrAB) overexpression and target topoisomerase gene (gyrAandparC) mutations over time in the emergence of quino

APA, Harvard, Vancouver, ISO, and other styles

31

Zhang, Moxi, Xinglong Chen, and Weifeng Lyu. "Research on the Evolution Characteristics and Influencing Factors of Foamy Oil Bubbles in Porous Media." Molecules 30, no. 5 (2025): 1163. https://doi.org/10.3390/molecules30051163.

Full text

Abstract:

This study systematically investigates the formation mechanism and development characteristics of the “foamy oil” phenomenon during pressure depletion development of high-viscosity crude oil through a combination of physical experiments and numerical simulations. Using Venezuelan foamy oil as the research subject, an innovative heterogeneous pore-etched glass model was constructed to simulate the pressure depletion process, revealing for the first time that bubble growth predominantly occurs during the migration stage. Experimental results demonstrate that heavy components significantly delay

APA, Harvard, Vancouver, ISO, and other styles

32

Momot, Volodymyr Ye, Olena M. Lytvynenko, and S. Zairzhanov. "SPECIFICS OF GAINING ECONOMIC INDEPENDENCE BY REFUGEES FROM UKRAINE." Academic Review 1, no. 58 (2023): 205–19. http://dx.doi.org/10.32342/2074-5354-2023-1-58-15.

Full text

Abstract:

The article examines the problems of the emergence and development of the flow of refugees from Ukraine during the first half of 2022 as a complex phenomenon that depends on rational (economic) and irrational (social-psychological) factors. The phenomenological model, created on the basis of the Burgers’ equation, which reproduces the process of the involvement of the new refugees to the flow and the resistance of the environment to the formation of this flow, made it possible to analyze such subtle effects as the existence of a hub country, where the initial accumulation of refugees takes pla

APA, Harvard, Vancouver, ISO, and other styles

33

McDonald, Anna G., Maureane Hoffman, Ulla Hedner, Harold R. Roberts, and Dougald M. Monroe. "Restoring Initial Thrombin Generation Does Not Normalize Cutaneous Wound Healing in Hemophilia B." Blood 108, no. 11 (2006): 1030. http://dx.doi.org/10.1182/blood.v108.11.1030.1030.

Full text

Abstract:

Abstract We recently described abnormal wound healing in a mouse model of hemophilia B (Hoffman et al, Blood 2006; DOI 10.1182/blood-2006-05-020495). Specifically: epithelial closure was delayed in hemophilia B mice; hemophilic animals, unlike wild type, developed subcutaneous hematomas; macrophage influx was delayed compared to wild-type mice; and, surprisingly, angiogenesis was enhanced in the hemophilia B mice. We hypothesized that restoring the initial hemostatic burst of thrombin generation following wounding by administration of a single dose of factor IX (FIX) replacement or factor VIIa

APA, Harvard, Vancouver, ISO, and other styles

34

Supriatna, Encep, and Syifa Aulia. "Transformasi Digital Sistem Pelayanan Pembuatan Surat Keterangan di Desa Cileunyi Wetan." Jurnal Accounting Information System (AIMS) 7, no. 1 (2024): 32–43. http://dx.doi.org/10.32627/aims.v7i1.914.

Full text

Abstract:

The Cileunyi Wetan Village Office is a village service center in activities such as governance, empowerment, development and counseling. The Certificate Making Service System in Cileunyi Wetan Village is currently still done manually, that is, people have to come directly to the village office on working days and hours. A system like this is not only very inconvenient for officers because they have to input data every time an application is made, it is also inconvenient for residents because they have to queue and wait for a long time. Moreover, if on the day in question the village head is un

APA, Harvard, Vancouver, ISO, and other styles

35

Anderson, Kristin G., Shannon K. Oda, Breanna M. Bates, et al. "Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in solid tumors." Journal of Immunology 204, no. 1_Supplement (2020): 246.8. http://dx.doi.org/10.4049/jimmunol.204.supp.246.8.

Full text

Abstract:

Abstract Over half of patients diagnosed with high grade serous ovarian cancer will die within five years, highlighting the need for therapy innovation. Engineering T cells to target proteins uniquely overexpressed in tumors has the potential to limit tumor growth without toxicity—mesothelin (Msln) is a rational immunotherapy target as it contributes to the malignant/invasive phenotype and has limited expression in healthy cells. T cells were engineered to express a high-affinity Msln-specific T cell receptor (TCRMsln) and adoptively transferred into a disseminated ID8VEGF murine model, which

APA, Harvard, Vancouver, ISO, and other styles

36

Chen, Ming, and Meimei Chen. "Privacy Relevance and Disclosure Intention in Mobile Apps: The Mediating and Moderating Roles of Privacy Calculus and Temporal Distance." Behavioral Sciences 15, no. 3 (2025): 324. https://doi.org/10.3390/bs15030324.

Full text

Abstract:

In digital societies, users’ privacy decisions not only affect personal information security and application sustainability, but also profoundly influence the formulation and enforcement of relevant laws. However, existing research mainly adopts a dichotomous perspective of rationality and bounded rationality, lacking an integrated framework to explain the complexity of users’ privacy decisions. Therefore, this study integrates privacy calculus theory and Psychological Distance Theory within the Elaboration Likelihood Model (ELM) framework to explore their mediating and moderating roles in the

APA, Harvard, Vancouver, ISO, and other styles

37

Timm, Michael, Linda Wellik, Teresa Kimlinger, et al. "Thymoglobulin (Polyclonal Rabbit Anti Thymocyte Globulin) Has In Vivo Activity in a Mouse Model of Myeloma." Blood 108, no. 11 (2006): 3487. http://dx.doi.org/10.1182/blood.v108.11.3487.3487.

Full text

Abstract:

Abstract Background: Multiple myeloma remains incurable with current approaches and newer therapies are needed to improve the outcome of these patients. While monoclonal antibody based therapies have been successful in some of the hematological malignancies, such approaches have had limited efficacy in the setting of myeloma. Thymoglobulin (polyclonal rabbit antithymocyte globulin, Genzyme) (Thymo) has been extensively evaluated in the setting of allogeneic blood and marrow transplantation and solid organ transplants. Given the polyclonal nature of this product, with antibodies against differe

APA, Harvard, Vancouver, ISO, and other styles

38

Saddawi-Konefka, Robert, Aoife O’Farrell, Farhoud Faraji, et al. "601 Sequencing immunotherapy before lymphatic ablation unleashes cDC1-dependent antitumor immunity in HNSCC." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A631. http://dx.doi.org/10.1136/jitc-2021-sitc2021.601.

Full text

Abstract:

BackgroundDespite the proven efficacy of immune checkpoint inhibitor (ICI) therapy in the recurrent/metastatic setting for head and neck squamous cell carcinoma (HNSCC), clinical trials of ICI combined with curative-intent therapies have yielded equivocal results [1–4]. Collectively, this highlights gaps in our understanding of rational immune oncology (IO) treatment sequencing and suggests that the efficacy ICI may be disrupted by standard therapies, which necessarily compromise regional lymphatics.MethodsWe employ a preclinical model of tobacco-signature HNSCC to identify sequences of therap

APA, Harvard, Vancouver, ISO, and other styles

39

Фадеева, Л. Ю. "Построение стохастической модели линейного экстраполятора для L-марковского фрактального процесса". Vestnik of Volga State University of Technology. Series Radio Engineering and Infocommunication Systems, № 1(65) (9 червня 2025): 46–54. https://doi.org/10.25686/2306-2819.2025.1.46.

Full text

Abstract:

К необходимости изучения задач экстраполяции, интерполяции и фильтрации случайных процессов и полей приводят проблемы в различных областях науки и техники. Одним из перспективных математических методов решения подобных задач является спектральное оценивание случайных процессов. В данной работе синтезирована модель линейного экстраполятора для L-марковского фрактального процесса с квазирациональным спектром. Показано, что при определённых значениях параметров квазирациональной спектральной плотности в классе L-марковских процессов существует подкласс процессов, обладающих фрактальными свойствам

APA, Harvard, Vancouver, ISO, and other styles

40

Petrovic, Mina. "Changes of marital behavior and family patterns in post-socialist countries: Delayed, incomplete or specific second demographic transition?" Stanovnistvo 49, no. 1 (2011): 53–78. http://dx.doi.org/10.2298/stnv1101053p.

Full text

Abstract:

The paper starts by questioning the theory of second demographic transition (SDT) and its universal relevance in the field of marriage behavior and family organization in low fertility context, arguing for more differentiated approaches. With an aim to illustrate the contextual specifics of post-socialist countries in general and of Serbia in particular, the author claims that analyzed changes have not just been delayed or incomplete in comparison to more developed European countries, but shaped by specific modernization processes, which led to rationally developed strategies in overcoming str

APA, Harvard, Vancouver, ISO, and other styles

41

Hajihassani, Omid, Ali Vaziri-Gohar, Mehrdad Zarei, et al. "Abstract 3021: Understanding the effects of a ketogenic diet against pancreatic cancer." Cancer Research 82, no. 12_Supplement (2022): 3021. http://dx.doi.org/10.1158/1538-7445.am2022-3021.

Full text

Abstract:

Abstract With an overall survival of less than 3%, pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer-related death in the U.S. at its advanced stages. With the most promising therapeutics, the overall survival after a stage IV PDAC diagnosis is only at 11.1 months. The marginal effects of current therapeutics emphasize the importance of developing new approaches to treat PDAC. In a wide range of cancer subtypes, a ketogenic diet has shown encouraging effects as combination therapy. However, the underlying anti-tumorigenic pathways involved in this diet alone are still

APA, Harvard, Vancouver, ISO, and other styles

42

Gopalakrishnapillai, Anilkumar, Anne Kisielewski, Yang Zhang, et al. "Evaluating the Efficacy of PRMT5 Inhibitor C220 in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia." Blood 138, Supplement 1 (2021): 1170. http://dx.doi.org/10.1182/blood-2021-151671.

Full text

Abstract:

Abstract Pediatric acute myeloid leukemia (AML) is the deadliest malignancy in children. Despite maximally intensive therapy, inclusive of chemotherapy and hematopoietic stem cell transplant, approximately 20% of patients experience recurrent disease. These patients are also burdened with treatment-related toxicities. Significant improvements in survival in pediatric AML patients necessitate the incorporation of rational targeted therapies with reduced toxicity. Recent studies demonstrate that PRMT5 knockout or inhibition in syngeneic mouse models of KMT2A (MLL) rearranged leukemic cells incre

APA, Harvard, Vancouver, ISO, and other styles

43

Lo, Jae Ho, Shivani Soni, Goar Smbatyan, et al. "Abstract 7221: A compound targeting the circadian clock protein CRY2 enhances therapeutic efficacy of bevacizumab in a colorectal cancer (CRC) xenograft model." Cancer Research 84, no. 6_Supplement (2024): 7221. http://dx.doi.org/10.1158/1538-7445.am2024-7221.

Full text

Abstract:

Abstract Anti VEGF A antibody Bevacizumab combined with standard chemotherapy has improved outcomes for CRC patients. However, a subset of CRC patients acquires resistance to anti-VEGF treatment and underlying mechanism is poorly understood. Our recent study reported that circadian clock transcription factor BMAL1 drives transcription of VEGFA conferring resistance to bevacizumab treatment. Our rational is to stabilize negative regulator of circadian clock CRY protein to inhibit BMAL1 activity in a negative feedback loop. In this study, we evaluated whether CRY stabilizers SHP656 and SHP1705 i

APA, Harvard, Vancouver, ISO, and other styles

44

Kolot, Svitlana О., and Anna L. Khristich. "Procrastination in the field of information technology." Informatics. Culture. Technology 1, no. 1 (2024): 290–96. http://dx.doi.org/10.15276/ict.01.2024.45.

Full text

Abstract:

In theses, the phenomenon of procrastination is observed as the voluntary postponement of things to the future, with the advantage of a current reward or escape from such an unpleasant experience. Its prevalence is indicated, it is shown that painting is associated not only with the negative consequences of delayed activity, but also with a decrease in well-being, a decrease in mental health, a decrease in productivity and financial difficulties. Attention is drawn to the conditionality of the procrastination of the spread of modern information technologies, which provide for new, often increa

APA, Harvard, Vancouver, ISO, and other styles

45

Magnani, John L., Arun Sarkar, Yonhong Li, et al. "GMI-1070: A Small Pan-Selectin Antagonist That Inhibits Leukocyte Adhesion and Migration in Multple Disease Models In Vivo." Blood 110, no. 11 (2007): 2410. http://dx.doi.org/10.1182/blood.v110.11.2410.2410.

Full text

Abstract:

Abstract Rational design of glycomimetic inhibitors based on the bioactive conformation of functional carbohydrates provides new therapeutic opportunities for the development of small molecule drugs with improved activity, pharmacokinetics, and bioavailability relative to native ligands. In designing more active glycomimetic selectin inhibitors, the low enthalpy (ΔH0) of the reaction is compensated by pre-forming the bioactive conformation thereby improving the entropy (ΔS0), known as S/H compensation. Modifications of the molecule that also stabilize the core structure, further improve ΔS0 an

APA, Harvard, Vancouver, ISO, and other styles

46

Smith, Eric L., Maria Lia Palomba, Jae H. Park, and Renier J. Brentjens. "A Systemic Xenograft Model of Waldenström’s Macroglobulinemia Demonstrates the Potent Anti-Tumor Effect of Second Generation CD19 Directed Chimeric Antigen Receptor Modified T Cells in This Disease." Blood 124, no. 21 (2014): 4484. http://dx.doi.org/10.1182/blood.v124.21.4484.4484.

Full text

Abstract:

Abstract Chimeric antigen receptor (CAR) modified T-cell therapy consists of ex-vivo genetic manipulation of autologous lymphocytes in order to establish robust T-cell mediated anti-tumor immunity. Our group was the first to design and evaluate a CAR targeted toward the B cell antigen CD19 in mice. Currently we utilize a second generation CAR comprised of a single-chain variable fragment (scFv) derived from an antibody against CD19 fused to the CD3 ζ chain and the CD28 intracellular signaling domain (19-28z) to provide the necessary signal 1 and signal 2 for enhanced T-cell activation and pers

APA, Harvard, Vancouver, ISO, and other styles

47

Stokes, Michael E., Feven Tameire, Paulina Wojnarowicz, et al. "Abstract 4615: HC-7366, a potent GCN2 activator, complements belzutifan, a HIF-2⍺ antagonist, by providing combination benefit in belzutifan-sensitive models and monotherapy activity in belzutifan-resistant models." Cancer Research 84, no. 6_Supplement (2024): 4615. http://dx.doi.org/10.1158/1538-7445.am2024-4615.

Full text

Abstract:

Abstract Recent approval of the HIF-2α antagonist belzutifan (Welireg) for patients with VHL disease has enabled the clinical opportunity to target the HIF-2 axis in cancer. This is particularly important for patients with clear cell renal cell carcinoma (ccRCC), in which 90% of tumors are VHL deficient, and approximately one in four primary tumors express HIF-2α exclusively. Clinical studies to date suggest an overall response rate (ORR) of 20-25% for belzutifan monotherapy, highlighting the need for a rational combination strategy to improve patient outcomes. This has led to multiple clinica

APA, Harvard, Vancouver, ISO, and other styles

48

Yousefzadeh, Matt. "INVESTIGATION OF TRANSCRIPTIONAL CHANGES IN IMMUNE CELL POPULATIONS OF MICE TREATED WITH RAPAMYCIN." Innovation in Aging 8, Supplement_1 (2024): 396. https://doi.org/10.1093/geroni/igae098.1289.

Full text

Abstract:

Abstract Aging is the greatest risk factor for many chronic degenerative diseases, for example osteoarthritis, dementia and heart disease. This robs individuals of quality of life and is very costly to treat. This has led to great interest in finding rational strategies for extending health span, the years of disease-free life at the end of one’s lifespan. Theoretically, if we could treat aging itself, all of the diseases associated with old age would be prevented, delayed or attenuated simultaneously. Thus, discovering fundamental mechanisms of aging is a priority. Aging is generally thought

APA, Harvard, Vancouver, ISO, and other styles

49

Kwag, Daehun, Byung Sik Cho, Gi June Min, et al. "Effects of Delayed Treatment on Patients with Acute Myeloid Leukemia; Treatment Delay Matters in Younger Patients." Blood 136, Supplement 1 (2020): 19–20. http://dx.doi.org/10.1182/blood-2020-143361.

Full text

Abstract:

Introduction Acute myeloid leukemia (AML) has been considered as a hematological emergency. However, debates on how much the time from diagnosis to treatment (TDT) can be justified to choose the optimal treatment in AML have been raised due to the increased possibility of customized treatment with novel targeted agents based on genetic abnormalities tested by newly applicable diagnostic tools. Three recent studies with a large data set from Western countries showed conflicting results about the relationship between TDT and prognosis. Thus, we evaluated the influence of TDT on patients' outcome

APA, Harvard, Vancouver, ISO, and other styles

50

Bojarczuk, Kamil, Kirsty Wienand, Jeremy A. Ryan та ін. "Targeted Inhibition of PI3K α/δ Is Synergistic with BCL-2 Blockade in Genetically Defined Subtypes of DLBCL". Blood 132, Supplement 1 (2018): 39. http://dx.doi.org/10.1182/blood-2018-99-113647.

Full text

Abstract:

Abstract Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous disease that is transcriptionally classified into germinal center B-cell (GCB) and activated B-cell (ABC) subtypes. A subset of both GCB- and ABC-DLBCLs are dependent on B-cell receptor (BCR) signaling. Previously, we defined distinct BCR/PI3K-mediated survival pathways and subtype-specific apoptotic mechanisms in BCR-dependent DLBCLs (Cancer Cell 2013 23:826). In BCR-dependent DLBCLs with low baseline NF-κB activity (GCB tumors), targeted inhibition or genetic depletion of BCR/PI3K pathway components induced express

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!