Academic literature on the topic 'Delivery challenges'

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Journal articles on the topic "Delivery challenges"

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Jimmy Khumalo, Mlungisi, Ireen Choga, and Elias Munapo. "Challenges associated with infrastructure delivery." Public and Municipal Finance 6, no. 2 (2017): 35–45. http://dx.doi.org/10.21511/pmf.06(2).2017.04.

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The main purpose of this paper is to document some challenges faced by Independent Development Trust (IDT) in infrastructure delivery of the provincial government of KwaZulu-Natal. Infrastructure delivery has a significant effect on the local budgets or budgets of projects in the province. The main focus of the study was the root causes of delays, budgetary overruns and the resultant effect on service delivery back-logs and socio-economic impact caused by such delays. The study setting comprised of professional stakeholders in the built environment and these include specialists and professiona
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Jazemi, Reza, Ensieh Alidadiani, Kwangseog Ahn, and Jaejin Jang. "A Review of Literature on Vehicle Routing Problems of Last-Mile Delivery in Urban Areas." Applied Sciences 13, no. 24 (2023): 13015. http://dx.doi.org/10.3390/app132413015.

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Logistics has long been important in an industrial society. Compared with the traditional structure of distribution, which requires freight to be delivered mostly to warehouses or retail stores, customers now often prefer packages to be delivered to their residences, especially after the delivery challenges during the COVID-19 pandemic. The delivery of parcels to urban residential areas increases the challenge due to the amount of delivery volume, tight delivery schedules, and continuously changing delivery conditions. Last-mile delivery tries to address the challenges, taking advantage of the
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Sruthi, Reddy Chittela1* Induru Jagadeesh2. "A Review On Microneedles: Scope, Strategies, Challenges And Methods." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 35–58. https://doi.org/10.5281/zenodo.10906502.

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Transdermal drug delivery (TDD) involves the delivery of drugs through the skin. This delivery system reduces side effects by avoiding vital organs like the liver, bypassing first-pass metabolism, and preventing drug degradation in the stomach. There are many types of TDD, including topical cream, hypodermic needle, transdermal patch, and microneedles. However, topical cream and transdermal patches take a long time to deliver drugs to the systemic circulation due to the stratum corneum in the skin acting as a barrier. While hypodermic needles deliver drugs into the systemic circulation, they o
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TARISH, ABDULSATTAR HASAN, and RAAD ISSA TAQI AL SHAMMAA. "Challenges and Innovations of Drug Delivery for Older Adults." Journal of Research on the Lepidoptera 50, no. 2 (2019): 40–50. http://dx.doi.org/10.36872/lepi/v50i2/201006.

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Liu, Yarong, Jennifer Rohrs, and Pin Wang. "Development and Challenges of Nanovectors in Gene Therapy." Nano LIFE 04, no. 03 (2014): 1441007. http://dx.doi.org/10.1142/s1793984414410074.

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In recent years, hundreds of genes have been linked to a variety of human diseases, and the field of gene therapy has emerged as a way to treat this wide range of diseases. The main goal of gene therapy is to find a gene delivery vehicle that can successfully target diseased cells and deliver therapeutic genes directly to their cellular compartment. The two main types of gene delivery vectors currently being investigated in clinical trials are recombinant viral vectors and synthetic nonviral vectors. Recombinant viral vectors take advantage of the evolutionarily optimized viral mechanisms to d
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Nainu, Firzan, Andi Dian Permana, Nana Juniarti Natsir Djide, et al. "Pharmaceutical Approaches on Antimicrobial Resistance: Prospects and Challenges." Antibiotics 10, no. 8 (2021): 981. http://dx.doi.org/10.3390/antibiotics10080981.

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The rapid increase in pathogenic microorganisms with antimicrobial resistant profiles has become a significant public health problem globally. The management of this issue using conventional antimicrobial preparations frequently results in an increase in pathogen resistance and a shortage of effective antimicrobials for future use against the same pathogens. In this review, we discuss the emergence of AMR and argue for the importance of addressing this issue by discovering novel synthetic or naturally occurring antibacterial compounds and providing insights into the application of various drug
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Prathap, B. N., K. C. Subrahmanya, and B. S. Harisha. "Microfinance Delivery – Challenges and Remedies." International Journal of Management Studies V, no. 3(9) (2018): 138. http://dx.doi.org/10.18843/ijms/v5i3(9)/17.

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Dalton, David. "‘Challenges to neurosurgical service delivery’." British Journal of Neurosurgery 21, no. 2 (2007): 187–89. http://dx.doi.org/10.1080/02688690701317185.

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Juliano, R. "Challenges to macromolecular drug delivery." Biochemical Society Transactions 35, no. 1 (2007): 41–43. http://dx.doi.org/10.1042/bst0350041.

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The use of macromolecules, particularly monoclonal antibodies, as therapeutic agents has come to the forefront in recent years. The biodistribution and delivery issues for protein drugs are shared to a substantial degree with other emerging therapeutic approaches including pharmacologically active nucleic acids and nanoparticles. A generalized approach to these issues involves consideration of the multiple biological barriers that stand between the macromolecular drug or nanoparticle at its site of administration and its ultimate biological target. Considerations of size, stability, non-specif
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Price, Martha J., and Patricia H. Parkerton. "Care Delivery Challenges for Nursing." AJN, American Journal of Nursing 107, Supplement (2007): 60–64. http://dx.doi.org/10.1097/01.naj.0000277835.43290.b7.

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Dissertations / Theses on the topic "Delivery challenges"

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Jalalian, Javadpour Hamid. "Mucus barrier components, challenges for nanoscale drug delivery." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for bioteknologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-23371.

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In this present study changes in nanoparticles motion were explored in the presence and the absence of G-blocks in mucus matrices such as; porcine gastric mucus (45 mg/ml), and a mixture of porcine gastric mucus + polymeric mucus (non degraded mucin from porcine stomach (45 mg/ml) respectively.These mucus types were tested to determine nanoparticle motion in their mesh networks, in order to deepen the understanding of nanoparticle motion behaviors in these complex biological environments, clarify the involvement of mucus components as motion barrier to nanoparticle diffusion, as well as identi
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Gwayi, Melwin Sandile. "Service delivery challenges : King Sabata Dalindyebo local municipality : Mthatha." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1541.

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This study aims to achieve the following four research objectives: - To investigate the challenges that led to the KSDLM experiencing poor municipal service delivery, and its constraints to effective implementation of the IDP. - To develop and propose effective strategies for the continuous improvement of service delivery and good governance in KSDLM with specific reference to the town of Mthatha. - To reveal counterproductive variances between legislation and governance instruments crafted by the municipality which may, as a result of misinterpretation, result in distortions in carrying out t
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Shasha, Zamuxolo. "An assessment of service delivery challenges: Intsika Yethu Municipality." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/d1015965.

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This study assesses service delivery challenges in Intsika Yethu Municipality with reference to water and electricity. This report presents the findings of a study conducted to identify the service delivery challenges related to the provision of basic services such as water and electricity, together with the recommendations on how these challenges can be resolved. This study was prompted by the huge number of backlogs experienced regarding water and electricity as well as complaints of non-service delivery and little understanding of the programme and plans within Intsika Yethu Municipality. T
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SALVIONI, LUCIA. "Nanoparticles-based delivery of biologic drugs: improvements and challenges." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241141.

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Per farmaci biologici si intende principi attivi prodotti o derivati da una fonte biologica. Essi sono ampiamente studiati/impiegati come alternativa alle tradizionali piccole molecole organiche in quanto generalmente posseggono maggior potenza e specificità. Nonostante i grandi vantaggi, il loro utilizzo rimane ancora piuttosto limitato per la scarsa biodisponibilità intrinseca. Infatti, la suscettibilità a degradazione chimica ed enzimatica e l’elevata dimensione ne impediscono l’accumulo e/o l’azione nel tessuto target. Tra le diverse strategie proposte per superare queste limitazioni, le
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Al-Sebie, Madi M. "Challenges facing transactional e-government systems." Thesis, Brunel University, 2005. http://bura.brunel.ac.uk/handle/2438/5069.

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A review of normative literature, in the field of e-government, indicates that the transactional stage of e-government is one of the most important to the implementation of an e-government system as it represents the highest level of interaction within organisations and between customers and government organisations. Due to the importance of the transactional stage of the e-government system and its positive impact, not only in making the delivery of external services quicker, but also in increasing the efficiency of internal government processes, government organisations might seek to reach t
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Mahlungulu, Zimkitha. "Challenges to service delivery in the Department of Home Affairs." Thesis, Nelson Mandela Metropolitan University, 2015. http://hdl.handle.net/10948/6573.

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The South African public sector is important for the sustainable growth and development of the country. One of its major responsibilities is to ensure that all citizens have access to and receive services. Achieving a high degree of productivity is an important objective of public service organisations across the world, given the pressure to deliver quality public goods and services within the limits of ever-increasing resource constraints. The South African public service is no exception to this global phenomenon. The challenge of the public service is therefore to continuously improve perfor
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Nazir, Saman. "Cesarean Section Delivery and Exclusive Breastfeeding in Pakistan: Emerging Challenges." Thesis, University of North Texas, 2019. https://digital.library.unt.edu/ark:/67531/metadc1538712/.

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This research examined two interrelated issues relevant to maternal and neonatal health in Pakistan, namely, the rising rates of C-section delivery and low rates of exclusive breastfeeding. By using the Andersen's health behavioral model to frame two empirical studies, the data from the Pakistan Demographic and Health Survey (PDHS) 2012-13 was used. The first empirical study examined the correlation between place of delivery and the odds of cesarean section in Pakistan. Not all Pakistani women have an equal chance of delivering at a health facility where C-section delivery takes place; therefo
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Lindström, Gustav. "The Challenges of adopting DevOps." Thesis, KTH, Skolan för industriell teknik och management (ITM), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-264179.

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In traditional Software Development Life Cycle, medium and large organizations tend to divide the activities of Operations and Development into separate departments. These groups often have a troublesome relationship because of different incentives during the software delivery process. As a result, conflicts occur between development and operations personnel as they blame each other to be the cause of long lead times and inefficient software delivery processes. The concept of DevOps emerged trying to resolve the problem that arises when separating the work of Development and Operations into or
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Kisera, Tetyana, and Тетяна Олегівна Кісера. "COVID vaccine: supply chain challenges." Thesis, National Aviation University, 2021. https://er.nau.edu.ua/handle/NAU/50508.

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1. Mia Rabson (2021). From science to syringe: COVID-19 vaccines are miracles of science and supply chains. CTV News (Bell Media). (Date of appeal: 20.03.2021) [Electronic resource]. - Access mode:https://www.ctvnews.ca/health/coronavirus/from-science-to-syringe-covid-19-vaccines-are-miracles-of-science-and-supply-chains-1.5327003 2. Reporting by Michael Shields; editing by Jason Neely (2021). Lonza gets Swiss OK to start Moderna vaccine production –paper. Reuters. (Date of appeal: 20.03.2021) [Electronic resource]. - Access mode:https://www.reuters.com/article/health-coronavirus-swiss/lonza
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Lööf, Erika, and Colin Mack. "Continuous Delivery : Utmaningar ett förvaltningsuppdrag kan stå inför vid en övergång till Continuous Delivery." Thesis, Högskolan Dalarna, Informatik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:du-23289.

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Continuous delivery (CD) is a software engineering approach where the focus lays on creating a short delivery cycle by automating parts of the deployment pipeline which includes build, deploy-, test and release process. CD is based on that during development should be possible to always automatically generate a release based on the source code in its current state. One of CD's many advantages is that through continuous releases it allows you to get a quick feedback loop leading to faster and more efficient implementation of new functions, at the same time fixing errors. Although CD has many ad
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Books on the topic "Delivery challenges"

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Kinam, Park, ed. Controlled drug delivery: Challenges and strategies. American Chemical Society, 1997.

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Addo, Richard T., ed. Ocular Drug Delivery: Advances, Challenges and Applications. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-47691-9.

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Mishra, Awanish, and Hitesh Kulhari, eds. Drug Delivery Strategies in Neurological Disorders: Challenges and Opportunities. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-6807-7.

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Cioffi, Christopher L., ed. Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-56619-7.

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Crew, Michael A., and Paul R. Kleindorfer, eds. Regulatory and Economic Challenges in the Postal and Delivery Sector. Springer US, 2005. http://dx.doi.org/10.1007/b102100.

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W, Murphy John, and Pardeck John T, eds. Technology and human service delivery: Challenges and a critical perspective. Haworth Press, 1988.

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American Bar Association. Forum Committee on Health Law., ed. Integrated delivery systems in a changing health care environment: New legal challenges. Forum on Health Law of the American Bar Association, 1994.

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Chinua, Akukwe, ed. Health services in Africa: Overcoming challenges, improving outcomes. Adonis & Abbey Publishers, 2008.

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Jay, Stanley, and Blair John D. 1944-, eds. Challenges in military health care: Perspectives on health status and the provision of care. Transaction Publishers, 1993.

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Sandra, Dawson, and Morris Zoë Slote, eds. Future public health: Burdens, challenges and opportunities. Palgrave macmillan, 2009.

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Book chapters on the topic "Delivery challenges"

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Mahajan, Vineet, Shruti Saptarshi, and Yashwant Pathak. "Regulatory Challenges for Gene Delivery." In Gene Delivery Systems. CRC Press, 2022. http://dx.doi.org/10.1201/9781003186083-15.

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Sheth, Divya, and Yashwant Pathak. "Challenges in Delivering Gene Therapy." In Gene Delivery Systems. CRC Press, 2022. http://dx.doi.org/10.1201/9781003186083-1.

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Wardwell, Patricia R., and Rebecca A. Bader. "Challenges of Drug Delivery." In Engineering Polymer Systems for Improved Drug Delivery. John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118747896.ch2.

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McKellar, James. "Challenges in project delivery." In Infrastructure as Business. Routledge, 2023. http://dx.doi.org/10.1201/9781003396949-25.

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Shah, Rakhi B., and Mansoor A. Khan. "Nanopharmaceuticals: Challenges and Regulatory Perspective." In Nanotechnology in Drug Delivery. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-77668-2_21.

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Rathod, Sapna, Nisarg Patel, and Bhupendra Prajapati. "Delivery System for Cancer Vaccine." In Cancer Vaccination and Challenges. Apple Academic Press, 2024. http://dx.doi.org/10.1201/9781003503071-1.

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Zare, Sajjad, Seyyed Mohammad Hosseini Verki, and Akbar Ghaffarpour Rahbar. "Channel-Zapping Time in IPTV: Challenges and Solutions." In IPTV Delivery Networks. John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119397939.ch6.

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Stubbs, Evan. "The Challenges of Tactical Delivery." In The Value of Business Analytics. John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118983881.ch3.

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Tillman, Lloyd G., and Gregory E. Hardee. "Biopharmaceutical Challenges: Delivery of Oligonucleotides." In Pharmacokinetics and Pharmacodynamics of Biotech Drugs. Wiley-VCH Verlag GmbH & Co. KGaA, 2006. http://dx.doi.org/10.1002/9783527609628.ch10.

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Csukás, Béla, Mónika Varga, Aleš Prokop, and Sándor Balogh. "Simulation Based Analysis of Nanocarrier Internalization: Exciting Challenges with a New Computational Tool." In Intracellular Delivery. Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-1248-5_5.

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Conference papers on the topic "Delivery challenges"

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Hemmati, Hamid, and Bahram Jalali. "Optical wireless power delivery: applications and challenges." In Optical Power Delivery, edited by Bahram Jalali. SPIE, 2025. https://doi.org/10.1117/12.3044390.

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Laird, Andrew. "Advanced Multi Axis Trim and Drill Cell for Low Volume, Multiple Part Configuration in a JIT Environment." In Vertical Flight Society 70th Annual Forum & Technology Display. The Vertical Flight Society, 2014. http://dx.doi.org/10.4050/f-0070-2014-9558.

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The aerospace manufacturing arena is a constantly evolving challenge to all of the participants. The conjuncture of continual cost-cutting pressures and product changes have created technical and system challenges to implant a manufacturing infrastructure that can cope and deliver widely different parts. All this in a climate of shorter delivery schedules and more complex parts geometries produced by advanced CAD systems. The challenge for equipment configuration is to create highly flexible robust machine configurations that can be adapted to multiple part configurations in the most efficient
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Moodley, Nageshwari, and Humairaa Ditta. "CHALLENGES OF INFORMATION AND COMMUNICATION TECHNOLOGY INTEGRATION ON CURRICULUM DELIVERY IN SOUTH AFRICAN SCHOOLS." In 19th International Technology, Education and Development Conference. IATED, 2025. https://doi.org/10.21125/inted.2025.0175.

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Slaughter, Mark. "Overcoming Corrosion Integrity Management Challenges for Storage Tanks and Associated Pipelines." In CORROSION 2019. NACE International, 2019. https://doi.org/10.5006/c2019-13340.

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Abstract Managing corrosion integrity for tanks and associated pipelines is a challenging and costly endeavor. In order to inspect tank floors, the tank's hydrocarbons or chemicals are usually emptied from the tank causing the tank to be out-of-service for an extended period of time. In addition to the monetary costs there is also a significantly increased safety risk. The associated piping for transferring the hydrocarbons and chemicals in and out of the storage tanks are an additional integrity risk. The delivery lines are not designed for traditional in-line inspection (ILI) tools, often ca
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Killeen, J. P., K. C. Dyson, K. D. Reeves, and D. Wolbers. "Large Diameter SCR Delivery Challenges." In Offshore Technology Conference. Offshore Technology Conference, 2005. http://dx.doi.org/10.4043/17286-ms.

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Pawar, Prof (Dr ). Sangeeta N., and Mr Danish Salim Lakdawala. "An Analytical Study of Consumers Enduring and Sharing Intention Towards Food Delivery Apps." In Intellectual Property Rights: Issues and Challenges. The Bhopal School of Social Sciences, 2025. https://doi.org/10.51767/c250632.

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Urban lifestyles, especially in cities like Dubai and Abu Dhabi, have contributed to an increased demand for convenient food delivery services. Consumers appreciate the ease of ordering diverse cuisine options, reflecting the multicultural makeup of the expatriate population in the UAE. Technological innovations, such as userfriendly mobile applications and real-time order tracking, enhance the overall customer experience. Collaborations with restaurants, strategic promotions, and loyalty programs are key strategies employed by food delivery platforms to attract and retain customers. The regul
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Loan, James F., Laura A. Sullivan, and John J. Sullivan. "Materials delivery challenges in ULSI processing." In Microelectronic Manufacturing '95, edited by Anant G. Sabnis and Ivo J. Raaijmakers. SPIE, 1995. http://dx.doi.org/10.1117/12.221326.

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Witters, Liesbeth, Peng Zhao, Gerald Beyer, and Eric Beyne. "Backside Power Delivery Process Integration Challenges." In 2024 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2024. http://dx.doi.org/10.7567/ssdm.2024.c-4-01.

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Aleksandrov, Oleg, and Elena Dobrolyubova. "Public Service Delivery through Automated Self-Service Kiosks." In EGOSE '15: Challenges in Eurasia. ACM, 2015. http://dx.doi.org/10.1145/2846012.2846048.

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Müller-Török, Robert, Arne Pautsch, and Alexander Prosser. "Legal Aspects of Cross-Border Delivery of Voting Documents." In EGOSE '15: Challenges in Eurasia. ACM, 2015. http://dx.doi.org/10.1145/2846012.2846013.

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Reports on the topic "Delivery challenges"

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Idris, Iffat. Service Delivery Modalities in Protracted FCV Settings. Institute of Development Studies, 2025. https://doi.org/10.19088/k4dd.2025.003.

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This review looks at modalities to deliver services in five sectors in fragile, conflict-affected and vulnerable (FCV) settings. The common challenge is how to bring about rapid delivery to meet pressing needs, without (further) undermining state systems. Modalities used were found to vary somewhat across the five sectors, e.g. some relying more on community participation, others on the private sector. However, in all five sectors a common focus in interventions considered to be effective was on: engaging local communities; working with community-based organizations; using public-private partn
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Levy, Alberto, Adriana M. Valencia J., and Ariel Yépez-García. The Energy Sector: Opportunities and Challenges. Inter-American Development Bank, 2016. http://dx.doi.org/10.18235/0010658.

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The analysis is informed by the particular circumstances and needs of each country, as well as by the goals of key regional energy integration initiatives. The energy sector is referred to here as all economic activities related to the use of renewable and nonrenewable resources for the production, delivery, and consumption of energy in its various forms, such as electricity, heat, or fuels for further processing, as well as the optimization of energy use through energy efficiency and conservation. To approach this complex set of relationships, this document presents the challenges of the sect
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Ali, Abdelrahman. Milestones and Challenges in Egypt’s Digital Financial Technology Adoption. Islamic Development Bank Institute, 2023. http://dx.doi.org/10.55780/re24041.

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Financial technology (Fintech) denotes the cutting-edge technologies transforming traditional financial services. Fintech involves the automation of financial service delivery, empowering financial service providers, businesses, and consumers to streamline their financial operations through specialized software on computers, smartphones, and various devices. Its scope has expanded beyond traditional financial services to encompass consumer-oriented sectors like education, retail banking, fundraising, digital currencies, and investment management. As with other nations, Egypt must embrace finan
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Pak, Kimchoeun. Fiscal Decentralisation in Cambodia: A Review of Progress and Challenges. Cambodia Development Resource Institute, 2011. https://doi.org/10.64202/wp.50.201105.

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To achieve democratic development, Cambodia’s next step towards fiscal decentralisation will focus on both institutional and service delivery reform at district level so as to strengthen the capacity of the sub-national administration and better link it to sectoral service delivery. To move forwards, fiscal decentralisation needs to be comprehensive and well coordinated with other cross-cutting reforms, especially the Public Financial Management Reform Programme, and sectoral reforms. This does not mean that everything has to be done at the same time, for doing so would overwhelm existing capa
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Zhou, Shengru, David J. Hurlbut, Lori A. Bird, and Qin Wang. Transmission Challenges and Best Practices for Cost-Effective Renewable Energy Delivery across State and Provincial Boundaries. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1377266.

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Zhou, Shengru, David J. Hurlbut, Lori A. Bird, and Qin Wang. Transmission Challenges and Best Practices for Cost-Effective Renewable Energy Delivery across State and Provincial Boundaries. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1377267.

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Zhou, Shengru, David J. Hurlbut, Lori A. Bird, and Qin Wang. Transmission Challenges and Best Practices for Cost-Effective Renewable Energy Delivery across State and Provincial Boundaries. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1377269.

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Zhou, Shengru, David J. Hurlbut, Lori A. Bird, and Qin Wang. Transmission Challenges and Best Practices for Cost-Effective Renewable Energy Delivery across State and Provincial Boundaries. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1377271.

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Zhou, Shengru, David J. Hurlbut, Lori A. Bird, and Qin Wang. Transmission Challenges and Best Practices for Cost-Effective Renewable Energy Delivery across State and Provincial Boundaries. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1377272.

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Zhou, Shengru, David J. Hurlbut, Lori A. Bird, and Qin Wang. Transmission Challenges and Best Practices for Cost-Effective Renewable Energy Delivery across State and Provincial Boundaries. Office of Scientific and Technical Information (OSTI), 2017. http://dx.doi.org/10.2172/1377273.

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