Academic literature on the topic 'Delivery Drug targeting Biodegradable polymeric'

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Journal articles on the topic "Delivery Drug targeting Biodegradable polymeric"

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Ahmed, Mohammed Abduljabbar. "Design and Synthesis of Biodegradable Polymeric Nanoparticles for Targeted Delivery of Chemotherapeutics in Triple-Negative Breast Cancer." SHIFAA 2023 (April 21, 2023): 1–11. http://dx.doi.org/10.70470/shifaa/2023/004.

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Type three breast cancer (TNBC) is a highly aggressive form of breast cancer that lacks targeted therapies, leading to poor prognosis and limited therapeutic options The development of biodegradable polymeric nanoparticles (NPs) provides find a promising strategy for targeted delivery of chemotherapeutic drugs to reduce systemic toxicity , enhancing therapeutic efficacy This review focuses on the design and synthesis of biodegradable polymeric nanoparticles for targeted delivery of chemotherapeutic agents in TNBC. Polymeric nanoparticles were synthesized from biocompatible and biodegradable ma
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Athira TR, K Selvaraju, and NL Gowrishankar. "Biodegradable polymeric nanoparticles: The novel carrier for controlled release drug delivery system." International Journal of Science and Research Archive 8, no. 1 (2023): 630–37. http://dx.doi.org/10.30574/ijsra.2023.8.1.0103.

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In the recent decades, polymers are widely used as biomaterials due to their favourable properties such as good biocompatibility, easy design and preparation, structural varieties and interesting bio-mimetic character. The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has shown significant therapeutic potential. Concurrently, targeted delivery technologies are becoming increasingly important as a scientific area of investigation. The current review entails an in-depth discussion of biodegradable polymeric nanoparticles with respect to types, formulation aspect
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Zhang, Hai, Jianqin Yan, Heng Mei, et al. "High-drug-loading capacity of redox-activated biodegradable nanoplatform for active targeted delivery of chemotherapeutic drugs." Regenerative Biomaterials 7, no. 4 (2020): 359–69. http://dx.doi.org/10.1093/rb/rbaa027.

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Abstract Challenges associated with low-drug-loading capacity, lack of active targeting of tumor cells and unspecific drug release of nanocarriers synchronously plague the success of cancer therapy. Herein, we constructed active-targeting, redox-activated polymeric micelles (HPGssML) self-assembled aptamer-decorated, amphiphilic biodegradable poly (benzyl malolactonate-co-ε-caprolactone) copolymer with disulfide linkage and π-conjugated moieties. HPGssML with a homogenous spherical shape and nanosized diameter (∼150 nm) formed a low critical micellar concentration (10−3 mg/mL), suggesting good
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Bianchini, Marta, Silvestro Micera, and Eugenio Redolfi Riva. "Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration." Pharmaceutics 15, no. 2 (2023): 640. http://dx.doi.org/10.3390/pharmaceutics15020640.

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When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the nerve regeneration process. However, in the case of consistent peripheral nerve damage, the regeneration capabilities are poor. Hence, a crucial challenge in this field is the development of biodegradable micro- nanostructured polymeric carriers for controlled and sustained release of molecules to enhance nerve regeneration. The aim of these sys
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Irene Silas Kaliki, Joyce Peter Kabissa, Pappu Kumar Singh, and Shivani Sharma. "Advances in Drug Delivery Systems." Journal of Pharma Insights and Research 2, no. 3 (2024): 088–95. http://dx.doi.org/10.69613/xakkge51.

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Drug delivery systems have undergone remarkable advancements in recent years, revolutionizing the way therapeutic agents are administered and enhancing their efficacy and safety profiles. This review explores the latest developments in drug delivery technologies, including biodegradable polymers, nanocarriers, and smart delivery systems responsive to specific physiological conditions. Nanotechnology-based delivery platforms, such as liposomes, dendrimers, and polymeric nanoparticles, have demonstrated impressive potential in improving drug targeting, bioavailability, reducing adverse effects,
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Strzelecka, Katarzyna, Urszula Piotrowska, Marcin Sobczak, and Ewa Oledzka. "The Advancement of Biodegradable Polyesters as Delivery Systems for Camptothecin and Its Analogues—A Status Report." International Journal of Molecular Sciences 24, no. 2 (2023): 1053. http://dx.doi.org/10.3390/ijms24021053.

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Camptothecin (CPT) has demonstrated antitumor activity in lung, ovarian, breast, pancreas, and stomach cancers. However, this drug, like many other potent anticancer agents, is extremely water-insoluble. Furthermore, pharmacology studies have revealed that prolonged schedules must be administered continuously. For these reasons, several of its water-soluble analogues, prodrugs, and macromolecular conjugates have been synthesized, and various formulation approaches have been investigated. Biodegradable polyesters have gained popularity in cancer treatment in recent years. A number of biodegrada
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Severino, Patricia, Classius F. da Silva, Luciana N. Andrade, Daniele de Lima Oliveira, Joana Campos, and Eliana B. Souto. "Alginate Nanoparticles for Drug Delivery and Targeting." Current Pharmaceutical Design 25, no. 11 (2019): 1312–34. http://dx.doi.org/10.2174/1381612825666190425163424.

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Nanotechnology refers to the control, manipulation, study and manufacture of structures and devices at the nanometer size range. The small size, customized surface, improved solubility and multi-functionality of nanoparticles will continue to create new biomedical applications, as nanoparticles allow to dominate stability, solubility and bioavailability, as well controlled release of drugs. The type of a nanoparticle, and its related chemical, physical and morphological properties influence its interaction with living cells, as well as determine the route of clearance and possible toxic effect
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Berillo, Dmitriy, Adilkhan Yeskendir, Zharylkasyn Zharkinbekov, Kamila Raziyeva, and Arman Saparov. "Peptide-Based Drug Delivery Systems." Medicina 57, no. 11 (2021): 1209. http://dx.doi.org/10.3390/medicina57111209.

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Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, dendrimers, polymeric micelles can be applied by intravenous administration, however they are of artificial nature and thus may induce side effects and possess lack of ability to penetrate the blood-brain barrier. An analysis of nontoxic drug delivery systems and an establishment of prospective t
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Pontes, Adriano P., Tim J. M. Welting, Jaap Rip, and Laura B. Creemers. "Polymeric Nanoparticles for Drug Delivery in Osteoarthritis." Pharmaceutics 14, no. 12 (2022): 2639. http://dx.doi.org/10.3390/pharmaceutics14122639.

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Osteoarthritis (OA) is a degenerative musculoskeletal disorder affecting the whole synovial joint and globally impacts more than one in five individuals aged 40 and over, representing a huge socioeconomic burden. Drug penetration into and retention within the joints are major challenges in the development of regenerative therapies for OA. During the recent years, polymeric nanoparticles (PNPs) have emerged as promising drug carrier candidates due to their biodegradable properties, nanoscale structure, functional versatility, and reproducible manufacturing, which makes them particularly attract
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Cho, Kye-Soo, Seo-Jin Hong, Min-Hye Ahn, et al. "Targeted Delivery of siRNA Therapeutics using Ligand Mediated Biodegradable Polymeric Nanocarriers." Current Pharmaceutical Design 24, no. 16 (2018): 1788–800. http://dx.doi.org/10.2174/1381612824666180702113345.

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Background: Cancer poses a major public health issue, is linked with high mortality rates across the world, and shows a strong interplay between genetic and environmental factors. To date, common therapeutics, including chemotherapy, immunotherapy, and radiotherapy, have made significant contributions to cancer treatment, although diverse obstacles for achieving the permanent “magic bullet” cure have remained. Recently, various anticancer therapeutic agents designed to overcome the limitations of these conventional cancer treatments have received considerable attention. One of these promising
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Dissertations / Theses on the topic "Delivery Drug targeting Biodegradable polymeric"

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Robishaw, Nikki K. "Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1530222031725709.

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Koosha, Fariba. "Preparation and characterisation of biodegradable polymeric drug carriers." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329839.

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Heffernan, Michael John. "Biodegradable polymeric delivery systems for protein subunit vaccines." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24787.

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Thesis (Ph.D.)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Dr. Niren Murthy; Committee Member: Dr. Carson Meredith; Committee Member: Dr. Julia Babensee; Committee Member: Dr. Mark Prausnitz; Committee Member: Dr. Ravi Bellamkonda.
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Redhead, Helen Margaret. "Drug loading of biodegradable nanoparticles for site specific drug delivery." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338495.

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Benzine, Youcef. "Enzymatically triggered polymeric drug delivery systems for colon targeting." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S036.

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De nos jours, les maladies inflammatoires chroniques de l'intestin (MICI) comme la rectocolite hémorragique et la maladie de Crohn touchent près de 200 000 personnes en France. Elles se caractérisent par l'inflammation de la paroi de différentes régions du tractus gastro-intestinal (TGI). Les deux sont des maladies chroniques qui impliquent une inflammation de la muqueuse colique. La principale différence entre la maladie de Crohn et la rectocolite hémorragique réside dans la localisation et la nature de l’inflammation. La maladie de Crohn peut toucher n’importe quelle partie du tractus gastro
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Asem, Heba. "Synthesis of Polymeric Nanocomposites for Drug Delivery and Bioimaging." Licentiate thesis, KTH, Funktionella material, FNM, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-186300.

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Nanomaterials have gained great attention for biomedical applications due to their extraordinary physico-chemical and biological properties. The current dissertation presents the design and development of multifunctional nanoparticles for molecular imaging and controlled drug delivery applications which include biodegradable polymeric nanoparticles, superparamagnetic iron oxide nanoparticles (SPION)/polymeric nanocomposite for magnetic resonance imaging (MRI) and drug delivery, manganese-doped zinc sulfide (Mn:ZnS) quantum dots (QDs)/ SPION/ polymeric nanocomposites for fluorescence imaging, M
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Fisher, Paul. "Additives to Control Mechanical Properties and Drug Delivery of Injectable Polymeric Scaffolds." UKnowledge, 2014. http://uknowledge.uky.edu/cbme_etds/25.

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In situ forming implants (ISIs) are popular due to their ease of use and local drug delivery potential, but they suffer from high initial drug burst, and release behavior is tied closely to solvent exchange and polymer properties. Additionally, such systems are traditionally viewed purely as drug delivery devices rather than potential scaffold materials due to their poor mechanical properties and minimal porosity. The aim of this research was to develop an injectable ISI with drug release, mechanical, and microstructural properties controlled by micro- and nanoparticle additives. First, an inj
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Hans, Meredith L. Lowman Anthony M. "Synthesis, characterization, and application of biodegradable polymeric prodrug micelles for long-term drug delivery /." Philadelphia, Pa. : Drexel University, 2006. http://dspace.library.drexel.edu/handle/1860/741.

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Aycan, Gunay. "Investigations On The Biodegradable Polymeric And Inorganic Substrates For Controlled Drug Delivery And Bone And Cartilage Repair." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609303/index.pdf.

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Tissue engineering is an interdisciplinary field that seeks to address the needs by applying the principles of chemistry, biology and engineering for the development of viable substitutes that restore and maintain the function of human bone and cartilage tissues. In tissue engineering, scaffolds play an important role as temporary supports for the transplantation of specific cells and tissues. In this study, poly(ester-urethane)urea (PEUU) and poly(caprolactone) (PCL) scaffolds were fabricated. Scaffolds were characterized by SEM. Porosities of scaffolds vary from 67 % to 80 %. Controlled
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Mawad, Damia Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "Development of Novel hydrogels for protein drug delivery." Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/25221.

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Introduction: Embolic agents are used to block blood flow of hypervascular tumours, ultimately resulting in target tissue necrosis. However, this therapy is limited by the formation of new blood vessels within the tumour, a process known as angiogenesis. Targeting angiogenesis led to the discovery of anti-angiogenic factors, large molecular weight proteins that can block the angiogenic process. The aim of this research is development of poly (vinyl alcohol) (PVA) aqueous solutions that cross-link in situ to form a hydrogel that functions as an embolic agent for delivery of macromolecular drugs
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Books on the topic "Delivery Drug targeting Biodegradable polymeric"

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I, Mahato Ram, ed. Biomaterials for delivery and targeting of proteins and nucleic acids. CRC Press, 2005.

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(Editor), Ronit Satchi-Fainaro, and Ruth Duncan (Editor), eds. Polymer Therapeutics I: Polymers as Drugs, Conjugates and Gene Delivery Systems (Advances in Polymer Science). Springer, 2006.

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Mahato, Ram I. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Taylor & Francis Group, 2004.

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Mahato, Ram I. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Taylor & Francis Group, 2005.

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Mahato, Ram I. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Taylor & Francis Group, 2004.

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Mahato, Ram I. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. CRC, 2004.

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Mahato, Ram I. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Taylor & Francis Group, 2004.

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Mahato, Ram I. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Taylor & Francis Group, 2004.

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Mahato, Ram I. Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Taylor & Francis Group, 2004.

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Book chapters on the topic "Delivery Drug targeting Biodegradable polymeric"

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Petersen, Robert V. "Biodegradable Drug Delivery Systems Based on Polypeptides." In Bioactive Polymeric Systems. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4757-0405-1_7.

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Das, Nilimanka. "Biodegradable Hydrogels for Controlled Drug Delivery." In Polymers and Polymeric Composites: A Reference Series. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-76573-0_47-1.

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Das, Nilimanka. "Biodegradable Hydrogels for Controlled Drug Delivery." In Polymers and Polymeric Composites: A Reference Series. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-77830-3_47.

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Pandit, Gaurav K., Ritesh K. Tiwari, Ashish Kumar, et al. "Natural Polymeric Nanoparticles for Brain Targeting." In Nanoarchitectonics for Brain Drug Delivery. CRC Press, 2024. http://dx.doi.org/10.1201/9781032661964-11.

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Fattal, Elias, Hervé Hillaireau, Simona Mura, Julien Nicolas, and Nicolas Tsapis. "Targeted Delivery Using Biodegradable Polymeric Nanoparticles." In Fundamentals and Applications of Controlled Release Drug Delivery. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-0881-9_10.

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Chevalier, Merari Tumin, Jimena Gonzalez, and Vera Alvarez. "Biodegradable Polymeric Microparticles as Drug Delivery Devices." In VI Latin American Congress on Biomedical Engineering CLAIB 2014, Paraná, Argentina 29, 30 & 31 October 2014. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-13117-7_49.

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Wiwanitkit, Viroj. "Biodegradable Nanoparticles for Drug Delivery and Targeting." In Surface Modification of Nanoparticles for Targeted Drug Delivery. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-06115-9_9.

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Kempe, Kristian, and Joseph A. Nicolazzo. "Biodegradable Polymeric Nanoparticles for Brain-Targeted Drug Delivery." In Neuromethods. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0838-8_1.

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Sumana, M., A. Thirumurugan, P. Muthukumaran, and K. Anand. "Biodegradable Natural Polymeric Nanoparticles as Carrier for Drug Delivery." In Integrative Nanomedicine for New Therapies. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-36260-7_8.

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Pandhare, Aditi, Priyanka Bhatt, Hardeep Singh Saluja, and Yashwant V. Pathak. "Biodegradable Polymeric Implants for Retina and Posterior Segment Disease." In Drug Delivery for the Retina and Posterior Segment Disease. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-95807-1_15.

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Conference papers on the topic "Delivery Drug targeting Biodegradable polymeric"

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Obayemi, John David, Winston Oluwole Soboyejo, Olushola S. Odusanya, Nicolas Anuku, Kathryn E. Uhrich, and Wei Yue. "Abstract B40: Injectable multifunctional biodegradable polymeric microspheres for localized drug delivery in breast cancer treatment." In Abstracts: Sixth AACR Conference: The Science of Cancer Health Disparities; December 6–9, 2013; Atlanta, GA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7755.disp13-b40.

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Soares, Joao S., James E. Moore, and Kumbakonam R. Rajagopal. "Constitutive Model of Biodegradable Non-Linear Polymeric Materials for Applications in the Biomedical Field." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176484.

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Synthetic biodegradable polymers have seen a dramatic increase in their availability and utilization over the last few decades. The first reported biomedical application of biodegradable polymers was during the 70s in biodegradable sutures and to date, it remains as the most widespread usage of this family of materials. Biodegradable polymers have also been proven to be effective carriers in local drug delivery therapies and are widely used as a primary constituent of scaffolds in tissue engineering applications.
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Uspenskaya, Mayya V., Petr P. Snetkov, Yuliya E. Generalova, and Svetlana N. Morozkina. "Drug Delivery Systems for Clinically used Drugs for Cardiac Amyloidosis Treatment: Preparation and Properties." In International Medicine and Health Sciences Congress. ECER, 2024. https://doi.org/10.53375/imhsc.2024.36.

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Cardiac amyloidosis is one of the leading causes of restrictive cardiomyopathy. It is typically rapidly progressive diastolic dysfunction in a non-dilated ventricle. Due to the numerous molecular pathways involved in the development andprogression of the disease, the drug molecules useful for cardiac amyloidosis are represented only by two small molecules, introduced in clinical application relatively recently. Here we present the comparative analysis of drug delivery systems for tafamidis and diflunisal, which have been developed in our group. The biosafe and biodegradable polymeric matrixes
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Debusschere, Nic, Matthieu De Beule, Patrick Segers, Benedict Verhegghe, and Peter Dubruel. "Modeling of Coated Biodegradable Stents." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80425.

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A bioresorbable stent supports the stenosed blood vessel during the healing period after coronary angioplasty and then gradually disappears. Unlike permanent stents, the biodegradable stent forms no obstacle for future interventions. Moreover, the degradable stent material presents an ideal vehicle for local drug delivery. Long term side effects inherent to drug eluting stents such as in-stent restenosis and late stent thrombosis might be avoided [1]. To date, several bioresorbable stents are being developed or are currently being tested in clinical trials. Two classes of biomaterials are bein
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Chebbi, A., J. Podporska, and J. Stokes. "Thermal Spraying of Bioactive Polymer Coatings for Orthopaedic Applications." In ITSC2011, edited by B. R. Marple, A. Agarwal, M. M. Hyland, et al. DVS Media GmbH, 2011. http://dx.doi.org/10.31399/asm.cp.itsc2011p0769.

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Abstract This research aims at introducing new biodegradable/non-biodegradable materials (biopolymers) to the existing Hydroxyapatite (HA)-titanium combination or as a single coating in order to overcome some of the limitations of HA coatings. Biopolymers can act as drug carriers for a localised drug release following implantation; they can also have a structural role by improving the mechanical performance of implants at the bone –implant interface. The proposed materials consisted of biodegradable and non-biodegradable polymers widely used as drug delivery systems: polymethylmethacrylate and
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Rahman, Shekh, and Narayan Bhattarai. "Magnesium Oxide Based PLGA/Chitosan Microparticles for Controlled Release Study." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52143.

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The performance of a therapeutic drug can be optimized by controlling the rate and extent of its release in the body. Polymeric microparticles are ideal vehicles for many controlled release drug delivery applications. Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable, biocompatible and FDA approved synthetic polymer. When PLGA based controlled release drug delivery devices are fabricated, the surface of PLGA is typically modified by other hydrophilic polymers. But some hydrophilic polymers, such as poly(ethylene glycol) (PEG) can negatively influence the therapeutic outcomes. The goal of
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Musa, Nafisah, and Tin Wui Wong. "Nanoparticles-in-soft microagglomerates as oral colon-specific cancer therapeutic vehicle." In 3rd International Congress of Engineering Sciences and Technology. Facultad de Ciencias de la Ingenierí­a y Tecnología, 2021. http://dx.doi.org/10.37636/recit.cicitec21.1.

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Polymeric nanoparticles can be conjugated with targeting ligand such as folate to elicit oral colon-specific drug delivery to treat colon cancer. Oral chemotherapy can be used as adjuvant, neo-adjuvant, or primary therapy. Nonetheless, oral cancer chemotherapeutics may experience premature drug release at the upper gastrointestinal tract due to the availability of a large specific dissolution surface area of nanoparticles leading to failure in colon cancer targeting. This study designed soft microagglomerates as carrier of nanoparticles to delay drug release. High molecular weight chitosan/pec
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Chebbi, A., and J. Stokes. "Design of Experiments Analysis of Flame Sprayed PCL/PMMA Bioactive Coatings." In ITSC 2012, edited by R. S. Lima, A. Agarwal, M. M. Hyland, et al. ASM International, 2012. http://dx.doi.org/10.31399/asm.cp.itsc2012p0219.

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Abstract Bioactive coatings are proven to enhance bone regeneration, implant integration and act as drug-delivery systems following bone replacement surgeries. Polycaprolactone (PCL) was used in this study as coating material due to its superior biocompatibility and biodegradability. Polymethyl-methacrylate (PMMA) was used as an additive in order to improve the flowability of the PCL powder. The processing technique used to obtain polymeric coatings was oxy-acetylene flame spraying. Seeing that biodegradable polymers were not thoroughly investigated in the past, a Design of Experiments (DoE) a
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Yeo, Leslie Y., and James R. Friend. "Surface Acoustic Waves: A New Paradigm for Driving Ultrafast Biomicrofluidics." In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18517.

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Surface acoustic waves (SAWs), which are 10 MHz order surface waves roughly 10 nm in amplitude propagating on the surface of a piezoelectric substrate, can offer a powerful method for driving fast microfluidic actuation and microparticle or biomolecule manipulation. We demonstrate that sessile drops can be linearly translated on planar substrates or fluid can be pumped through microchannels at typically one to two orders of magnitude faster than that achievable through current microfluidic technologies. Micromixing can be induced in the same microchannel in which fluid is pumped using the SAW
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