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Dissertations / Theses on the topic 'Delivery Drug targeting Biodegradable polymeric'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Robishaw, Nikki K. "Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1530222031725709.

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2

Koosha, Fariba. "Preparation and characterisation of biodegradable polymeric drug carriers." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329839.

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3

Heffernan, Michael John. "Biodegradable polymeric delivery systems for protein subunit vaccines." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24787.

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Thesis (Ph.D.)--Biomedical Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Dr. Niren Murthy; Committee Member: Dr. Carson Meredith; Committee Member: Dr. Julia Babensee; Committee Member: Dr. Mark Prausnitz; Committee Member: Dr. Ravi Bellamkonda.

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4

Redhead, Helen Margaret. "Drug loading of biodegradable nanoparticles for site specific drug delivery." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338495.

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5

Benzine, Youcef. "Enzymatically triggered polymeric drug delivery systems for colon targeting." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S036.

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De nos jours, les maladies inflammatoires chroniques de l'intestin (MICI) comme la rectocolite hémorragique et la maladie de Crohn touchent près de 200 000 personnes en France. Elles se caractérisent par l'inflammation de la paroi de différentes régions du tractus gastro-intestinal (TGI). Les deux sont des maladies chroniques qui impliquent une inflammation de la muqueuse colique. La principale différence entre la maladie de Crohn et la rectocolite hémorragique réside dans la localisation et la nature de l’inflammation. La maladie de Crohn peut toucher n’importe quelle partie du tractus gastro

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6

Asem, Heba. "Synthesis of Polymeric Nanocomposites for Drug Delivery and Bioimaging." Licentiate thesis, KTH, Funktionella material, FNM, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-186300.

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Nanomaterials have gained great attention for biomedical applications due to their extraordinary physico-chemical and biological properties. The current dissertation presents the design and development of multifunctional nanoparticles for molecular imaging and controlled drug delivery applications which include biodegradable polymeric nanoparticles, superparamagnetic iron oxide nanoparticles (SPION)/polymeric nanocomposite for magnetic resonance imaging (MRI) and drug delivery, manganese-doped zinc sulfide (Mn:ZnS) quantum dots (QDs)/ SPION/ polymeric nanocomposites for fluorescence imaging, M

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7

Fisher, Paul. "Additives to Control Mechanical Properties and Drug Delivery of Injectable Polymeric Scaffolds." UKnowledge, 2014. http://uknowledge.uky.edu/cbme_etds/25.

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In situ forming implants (ISIs) are popular due to their ease of use and local drug delivery potential, but they suffer from high initial drug burst, and release behavior is tied closely to solvent exchange and polymer properties. Additionally, such systems are traditionally viewed purely as drug delivery devices rather than potential scaffold materials due to their poor mechanical properties and minimal porosity. The aim of this research was to develop an injectable ISI with drug release, mechanical, and microstructural properties controlled by micro- and nanoparticle additives. First, an inj

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8

Hans, Meredith L. Lowman Anthony M. "Synthesis, characterization, and application of biodegradable polymeric prodrug micelles for long-term drug delivery /." Philadelphia, Pa. : Drexel University, 2006. http://dspace.library.drexel.edu/handle/1860/741.

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9

Aycan, Gunay. "Investigations On The Biodegradable Polymeric And Inorganic Substrates For Controlled Drug Delivery And Bone And Cartilage Repair." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609303/index.pdf.

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Tissue engineering is an interdisciplinary field that seeks to address the needs by applying the principles of chemistry, biology and engineering for the development of viable substitutes that restore and maintain the function of human bone and cartilage tissues. In tissue engineering, scaffolds play an important role as temporary supports for the transplantation of specific cells and tissues. In this study, poly(ester-urethane)urea (PEUU) and poly(caprolactone) (PCL) scaffolds were fabricated. Scaffolds were characterized by SEM. Porosities of scaffolds vary from 67 % to 80 %. Controlled

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10

Mawad, Damia Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "Development of Novel hydrogels for protein drug delivery." Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/25221.

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Introduction: Embolic agents are used to block blood flow of hypervascular tumours, ultimately resulting in target tissue necrosis. However, this therapy is limited by the formation of new blood vessels within the tumour, a process known as angiogenesis. Targeting angiogenesis led to the discovery of anti-angiogenic factors, large molecular weight proteins that can block the angiogenic process. The aim of this research is development of poly (vinyl alcohol) (PVA) aqueous solutions that cross-link in situ to form a hydrogel that functions as an embolic agent for delivery of macromolecular drugs

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11

Clementi, Chiara. "Studies on polymer conjugation as versatile tool for drug delivery." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422488.

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Drug delivery is a rapidly evolving field aimed to maximize the potential and safety of therapeutic agents. The project of this thesis focused on development and characterization of drug delivery systems (DDSs), based on polymeric carriers. Among, the advantages of these systems it is possible to list an increased solubility, a prolonged exposure of the drug, a protection from enzymatic degradation and a controlled release of drug and an accumulation in diseased tissues. The DDSs developed here were firs tested in the context of cancer therapy where the delivery, controlled release and targe

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12

Tuli, Rinku. "Studies on the surface properties of biodegradable polymer carriers in respiratory delivery of drug from Dry Powder Inhaler formulations." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53295/1/Rinku_Tuli_thesis.pdf.

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Dry Powder Inhaler (DPI) technology has a significant impact in the treatment of various respiratory disorders. DPI formulations consist of a micronized drug (<5ìm) blended with an inert coarse carrier, for which lactose is widely used to date. DPIs are one of the inhalation devices which are used to target the delivery of drugs to the lungs. Drug delivery via DPI formulations is influenced by the physico-chemical characteristics of lactose particles such as size, shape, surface roughness and adhesional forces. Commercially available DPI formulations, which utilise lactose as the carrier, are

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13

Ditto, Andrew James. "Biodegradable Nanoparticles for Use as an Inhalable Antimicrobial and as a Receptor Targeted Delivery Device." University of Akron / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=akron1280335303.

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14

Yang, Stephen Chen. "Polyketals a new drug delivery platform for treating acute liver failure /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31785.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Murthy, Niren; Committee Member: Bellamkonda, Ravi; Committee Member: Davis, Michael; Committee Member: May, Sheldon; Committee Member: Milam, Valeria. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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15

Guo, Qiongyu. "POSS-Based Biodegradable Polymers for Stent Applications: Electroprocessing, Characterization and Controlled Drug Release." Cleveland, Ohio : Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1259706279.

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Thesis(Ph.D.)--Case Western Reserve University, 2010<br>Title from PDF (viewed on 2009-12-22) Department of Macromolecular Science and Engineering Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center

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16

Roberts, Emily Remsen Hogan. "Microfluidics-Generated Biodegradable Polymeric Microparticles for Controlled Drug Delivery." Diss., 2014. http://hdl.handle.net/10161/9391.

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<p>While drug-loaded biodegradable polymer microparticles have found many therapeutic applications, bulk manufacturing methods produce heterogeneous populations of particles. A more highly controlled manufacturing method may provide the ability improve the microparticle characteristics such as the drug release profile. Microfluidic droplet-makers manipulate liquids on the scale of tens of microns and can produce highly regular and controlled emulsions. However, microfluidic droplet manufacturing is not typically designed for clinical translation and the chemicals used are often not biocompatib

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17

Ho, Karyn. "Targeted Drug Delivery to Breast Cancer using Polymeric Nanoparticle Micelles." Thesis, 2012. http://hdl.handle.net/1807/34054.

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Broad distribution and activity limit the utility of anti-cancer compounds by causing unacceptable systemic toxicity and narrow therapeutic indices. To improve tumour accumulation, drug-loaded macromolecular assemblies have been designed to replace conventional surfactant-based formulations. Their nanoscale size enhances tumour accumulation via hyperpermeable vasculature and reduced lymphatic drainage. Incorporating targeting ligands introduces cell specificity through receptor-specific binding and uptake, enabling drugs to reach intracellular targets. In this work, the targeting propertie

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18

Yu, Shi, and Gan-Moog Chow. "Synthesis and Characterization of a Magnetically Responsive Polymeric Drug Delivery System." 2003. http://hdl.handle.net/1721.1/3795.

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A magnetic target drug delivery system consisting of biodegradable polymeric microspheres (poly D, L-lactic acid) loaded with magnetite nanoparticles (10-100 nm) and anticancer drug (paclitaxel) was studied. The magnetite nanoparticles were synthesized by chemical precipitation. The as-synthesized magnetite nanoparticles were subsequently introduced into a mixture of polymer magnetic polymeric composite particles were investigated and further correlated with the reaction parameters. It was found that the size and characteristics of the polymeric composite particles depended on the viscosity of

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19

SERRI, CARLA. "Amphiphilic biodegradable nanoparticles for optimization of drug delivery and targeting in cancer treatment." Doctoral thesis, 2017. http://hdl.handle.net/11570/3103561.

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It is widely recognized that biodegradable nanoparticles may play an important role for developing new drug delivery systems, especially in the case of drugs which cannot be used properly due to their characteristics (such as low solubility and low bioavailability) so increasing their therapeutic efficacy and minimizing the side effects. The researches reported in this thesis had the aim to develop two nanosystems designed to optimize the delivery of drugs and their active or passive targeting to tumor cells, respectively: as to passive targeting, a nanosystem based on an amphiphilic blend of

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20

Huang, Shang-Jen, and 黃上人. "Synthesis and Evaluation of Novel Biodegradable Nano-Polymeric for Bone-Targeted Drug Delivery Systems." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/98573058647324678475.

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碩士<br>高雄醫學大學<br>醫藥暨應用化學研究所<br>96<br>Because of musculoskeletal diseases have lacked of targeting drug delivery systems, result in delivering the drug not on correct part to cure. Using this drug more often than not only to treatment of these disease but brings other side effect. And water-insoluble drug unable to intravenous (IV) injection. Using oral medicine, in order to reach effective drug concentration, high systemic doses of the therapeutic must often administered, which may lead to significant adverse systemic and side effect. Taking medicine everyday or inject therapeutic agent to pati

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21

Nwadibia, Ekeoma C. "Chemical Targeting of Specific Cell Types in Living Brain Tissue." Thesis, 2018. https://doi.org/10.7916/D812754J.

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This thesis details our early efforts towards the discovery of polymeric and macromolecular platforms for the targeted delivery of sensors and actuators to specific cell types in the living brain tissue. Chapter 1 of this thesis discusses the small molecule tropane tag chosen as a homing ligand and the dopamine transporter (DAT) chosen as a cellular target, as well as the synthesis of new tropane-based molecular tags for evaluation in cultured human DAT (hDAT)-expressing cells and targeting in brain tissue. Chapter 2 discusses the results obtained from evaluation of the new tropane tags in hDA

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22

Chi-MingHuang and 黃祈銘. "Stimuli-responsive and Targeting Polymeric Micelles for the Applications of Controlled Drug Release and Target Delivery." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/40019228348250310986.

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碩士<br>國立成功大學<br>化學工程學系碩博士班<br>101<br>In this work, a new series of mixed polymeric micelles with multi-functionalities was investigated and their application as the carrier of anti-cancer drugs was explored. These micelles were self-assembled from two amphiphilic diblock copolymers, poly(ɛ-caprolactone)-b-poly[triethylene glycol methacrylate-co- 6-(methacrylamido)hexanoic acid] [PCL-b-P(TEGMA-co-AHA)] and poly(ɛ-caprolactone)-b-poly[triethylene glycol methacrylate-co- N-(2-(methacrylamido)ethyl) folatic amide] [PCL-b-P(TEGMA-co-FA)]. The hydrophobic core of micelles composed of the PCL block c

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23

Maretschek, Sascha [Verfasser]. "Novel techniques for the incorporation of proteins in biodegradable polymeric drug delivery devices for their controlled release / vorgelegt von Sascha Maretschek." 2009. http://d-nb.info/995881332/34.

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24

施宗甫. "Magnetic and pH-Responsive Complex Polymeric Vesicles as a Theranostic Nanoplatform for Tumor-Targeting Drug Delivery and Enhanced MR Imaging." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/92569956325591050722.

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碩士<br>國立清華大學<br>生醫工程與環境科學系<br>100<br>In this study, a multifunctional and pH-responsive polymeric complex vesicle as an anticancer drug and MRI contrast agent carrier has been developed for cancer theranostics. The superparamagnetic iron oxide (SPIO)-loaded polymeric vesicles (ca. 110 nm) were formed by self-assembly of the poly(acrylic acid-co-disterin acrylate) (P(AAc-co-DSA)) in the SPIO aqueous solution (pH 5.0) via sonication technique while the SPIO was simultaneously encapulated into the interior aqueous compartment of the vesicles. The anticancer drug, doxorubicin (DOX), was then loade

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25

Maniego, Alison R. "Characterization of branched poly(acrylic acid) via capillary electrophoresis and NMR spectroscopy for anticancer drug targeting and delivery." Thesis, 2018. http://hdl.handle.net/1959.7/uws:46101.

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The non-selective nature of anticancer drugs leads to harmful side-effects. This work investigates the branched polymer, poly(acrylic acid), PAA, and its salt, poly(sodium acrylate), PNaA, for their potential as an anticancer drug carrier for better targeted delivery. The binding between the anticancer drug cisplatin and PNaA was investigated using capillary electrophoresis in the critical conditions (CE-CC). The average degree of branching (DB) was also quantified using NMR spectroscopy. The influence of the synthetic parameters on the DB was also investigated. The precision and accuracy of

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26

Ghotbi, Zahra. "PLGA-based nanoparticles for targeting of dendritic cells in cancer immunotherapy and immunomonitoring." Master's thesis, 2010. http://hdl.handle.net/10048/1016.

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Thesis (M.Sc.)--University of Alberta, 2010.<br>A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science in Pharmaceutical Sciences. Title from pdf file main screen (viewed on February 17, 2010). Includes bibliographical references.

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27

Σεργίδης, Ανδρέας. "Μελέτη των παραμέτρων της σύνθεσης υβριδικών κολλοειδών νανοκρυστάλλων με υπερπαραμαγνητικές ιδιότητες για την ανάπτυξη πολυλειτουργικών συστημάτων ελεγχόμενης χορήγησης αντικαρκινικών ουσιών". Thesis, 2014. http://hdl.handle.net/10889/8576.

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Η Πακλιταξέλη (PTX) αποτελεί ένα ευρέως διαδεδομένο αντινεοπλασματικό φάρμακο και ενδείκνυται σε μεταστατικό καρκίνο του μαστού, καρκίνο ωοθηκών, μη μικροκυτταρικό καρκίνο του πνεύμονα και σε σάρκωμα Kaposi ασθενών με AIDS. Παρ’ όλα αυτά, η σημαντική τοξικότητα που εμφανίζει (μυελοκαταστολή, νευροτοξικότητα, αντιδράσεις υπερευαισθησίας), υπογραμμίζει την αναγκαιότητα για μορφοποίησή της σε Συστήματα Ελεγχόμενης Χορήγησης Φαρμάκων (DDS), με σκοπό τη μείωση των ανεπιθύμητων ενεργειών και την αύξηση της βιοδιαθεσιμότητας του φαρμάκου. Τα πολυμερικά μικκύλια έχουν μελετεθεί εκτενώς τα τελευταία

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