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Journal articles on the topic 'Delivery Drug targeting Biodegradable polymeric'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Ahmed, Mohammed Abduljabbar. "Design and Synthesis of Biodegradable Polymeric Nanoparticles for Targeted Delivery of Chemotherapeutics in Triple-Negative Breast Cancer." SHIFAA 2023 (April 21, 2023): 1–11. http://dx.doi.org/10.70470/shifaa/2023/004.

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Type three breast cancer (TNBC) is a highly aggressive form of breast cancer that lacks targeted therapies, leading to poor prognosis and limited therapeutic options The development of biodegradable polymeric nanoparticles (NPs) provides find a promising strategy for targeted delivery of chemotherapeutic drugs to reduce systemic toxicity , enhancing therapeutic efficacy This review focuses on the design and synthesis of biodegradable polymeric nanoparticles for targeted delivery of chemotherapeutic agents in TNBC. Polymeric nanoparticles were synthesized from biocompatible and biodegradable ma

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Athira TR, K Selvaraju, and NL Gowrishankar. "Biodegradable polymeric nanoparticles: The novel carrier for controlled release drug delivery system." International Journal of Science and Research Archive 8, no. 1 (2023): 630–37. http://dx.doi.org/10.30574/ijsra.2023.8.1.0103.

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In the recent decades, polymers are widely used as biomaterials due to their favourable properties such as good biocompatibility, easy design and preparation, structural varieties and interesting bio-mimetic character. The use of biodegradable polymeric nanoparticles (NPs) for controlled drug delivery has shown significant therapeutic potential. Concurrently, targeted delivery technologies are becoming increasingly important as a scientific area of investigation. The current review entails an in-depth discussion of biodegradable polymeric nanoparticles with respect to types, formulation aspect

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Zhang, Hai, Jianqin Yan, Heng Mei, et al. "High-drug-loading capacity of redox-activated biodegradable nanoplatform for active targeted delivery of chemotherapeutic drugs." Regenerative Biomaterials 7, no. 4 (2020): 359–69. http://dx.doi.org/10.1093/rb/rbaa027.

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Abstract Challenges associated with low-drug-loading capacity, lack of active targeting of tumor cells and unspecific drug release of nanocarriers synchronously plague the success of cancer therapy. Herein, we constructed active-targeting, redox-activated polymeric micelles (HPGssML) self-assembled aptamer-decorated, amphiphilic biodegradable poly (benzyl malolactonate-co-ε-caprolactone) copolymer with disulfide linkage and π-conjugated moieties. HPGssML with a homogenous spherical shape and nanosized diameter (∼150 nm) formed a low critical micellar concentration (10−3 mg/mL), suggesting good

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Bianchini, Marta, Silvestro Micera, and Eugenio Redolfi Riva. "Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration." Pharmaceutics 15, no. 2 (2023): 640. http://dx.doi.org/10.3390/pharmaceutics15020640.

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When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue is the implantation of a biodegradable polymeric tubular scaffold, providing a biomimetic environment to support the nerve regeneration process. However, in the case of consistent peripheral nerve damage, the regeneration capabilities are poor. Hence, a crucial challenge in this field is the development of biodegradable micro- nanostructured polymeric carriers for controlled and sustained release of molecules to enhance nerve regeneration. The aim of these sys

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Irene Silas Kaliki, Joyce Peter Kabissa, Pappu Kumar Singh, and Shivani Sharma. "Advances in Drug Delivery Systems." Journal of Pharma Insights and Research 2, no. 3 (2024): 088–95. http://dx.doi.org/10.69613/xakkge51.

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Drug delivery systems have undergone remarkable advancements in recent years, revolutionizing the way therapeutic agents are administered and enhancing their efficacy and safety profiles. This review explores the latest developments in drug delivery technologies, including biodegradable polymers, nanocarriers, and smart delivery systems responsive to specific physiological conditions. Nanotechnology-based delivery platforms, such as liposomes, dendrimers, and polymeric nanoparticles, have demonstrated impressive potential in improving drug targeting, bioavailability, reducing adverse effects,

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Strzelecka, Katarzyna, Urszula Piotrowska, Marcin Sobczak, and Ewa Oledzka. "The Advancement of Biodegradable Polyesters as Delivery Systems for Camptothecin and Its Analogues—A Status Report." International Journal of Molecular Sciences 24, no. 2 (2023): 1053. http://dx.doi.org/10.3390/ijms24021053.

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Camptothecin (CPT) has demonstrated antitumor activity in lung, ovarian, breast, pancreas, and stomach cancers. However, this drug, like many other potent anticancer agents, is extremely water-insoluble. Furthermore, pharmacology studies have revealed that prolonged schedules must be administered continuously. For these reasons, several of its water-soluble analogues, prodrugs, and macromolecular conjugates have been synthesized, and various formulation approaches have been investigated. Biodegradable polyesters have gained popularity in cancer treatment in recent years. A number of biodegrada

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Severino, Patricia, Classius F. da Silva, Luciana N. Andrade, Daniele de Lima Oliveira, Joana Campos, and Eliana B. Souto. "Alginate Nanoparticles for Drug Delivery and Targeting." Current Pharmaceutical Design 25, no. 11 (2019): 1312–34. http://dx.doi.org/10.2174/1381612825666190425163424.

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Nanotechnology refers to the control, manipulation, study and manufacture of structures and devices at the nanometer size range. The small size, customized surface, improved solubility and multi-functionality of nanoparticles will continue to create new biomedical applications, as nanoparticles allow to dominate stability, solubility and bioavailability, as well controlled release of drugs. The type of a nanoparticle, and its related chemical, physical and morphological properties influence its interaction with living cells, as well as determine the route of clearance and possible toxic effect

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Berillo, Dmitriy, Adilkhan Yeskendir, Zharylkasyn Zharkinbekov, Kamila Raziyeva, and Arman Saparov. "Peptide-Based Drug Delivery Systems." Medicina 57, no. 11 (2021): 1209. http://dx.doi.org/10.3390/medicina57111209.

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Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, dendrimers, polymeric micelles can be applied by intravenous administration, however they are of artificial nature and thus may induce side effects and possess lack of ability to penetrate the blood-brain barrier. An analysis of nontoxic drug delivery systems and an establishment of prospective t

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Pontes, Adriano P., Tim J. M. Welting, Jaap Rip, and Laura B. Creemers. "Polymeric Nanoparticles for Drug Delivery in Osteoarthritis." Pharmaceutics 14, no. 12 (2022): 2639. http://dx.doi.org/10.3390/pharmaceutics14122639.

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Osteoarthritis (OA) is a degenerative musculoskeletal disorder affecting the whole synovial joint and globally impacts more than one in five individuals aged 40 and over, representing a huge socioeconomic burden. Drug penetration into and retention within the joints are major challenges in the development of regenerative therapies for OA. During the recent years, polymeric nanoparticles (PNPs) have emerged as promising drug carrier candidates due to their biodegradable properties, nanoscale structure, functional versatility, and reproducible manufacturing, which makes them particularly attract

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Cho, Kye-Soo, Seo-Jin Hong, Min-Hye Ahn, et al. "Targeted Delivery of siRNA Therapeutics using Ligand Mediated Biodegradable Polymeric Nanocarriers." Current Pharmaceutical Design 24, no. 16 (2018): 1788–800. http://dx.doi.org/10.2174/1381612824666180702113345.

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Background: Cancer poses a major public health issue, is linked with high mortality rates across the world, and shows a strong interplay between genetic and environmental factors. To date, common therapeutics, including chemotherapy, immunotherapy, and radiotherapy, have made significant contributions to cancer treatment, although diverse obstacles for achieving the permanent “magic bullet” cure have remained. Recently, various anticancer therapeutic agents designed to overcome the limitations of these conventional cancer treatments have received considerable attention. One of these promising

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Verma, Navneet Kumar, Gulzar Alam, Vishwakarma D K, et al. "Recent Advances in Microspheres Technology for Drug Delivery." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 2 (2015): 2799–813. http://dx.doi.org/10.37285/ijpsn.2015.8.2.2.

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Microspheres are the novel drug delivery system. A well considered controlled drug delivery system can overcome some of the problems of predictable therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release approach. A Microspheres has its drug dispersed throughout the particle i.e., the internal structure is a matrix of drug and polymeric excipients. It is the reliable means to deliver the drug to the target site with specificity, if modified and to maintain the desired c

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Patil, Prashant, Komal Harak, and Ravindra Saudagar. "THE Solid lipid nanoparticles A review." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 525–30. http://dx.doi.org/10.22270/jddt.v9i3.2773.

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Solid lipid nanoparticles are novel drug delivery system its to improve the solubility and bioavailability of the drug it has been proved that SLN is more effective colloidal drug delivery system because of it is more controlled and targeting properties, the SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs, the bioacceptable and biodegradable nature of SLN makes them less toxic as compared to polymeric nanoparticles, it has several potential applications in drug delivery, clinical medicine and research as well as in other varied science, in this present review t

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Jayprakash, Khandelwal Mohit, Agrawal Dilip, and Goyal Rakesh. "COLON TARGETED DRUG DELIVERY SYSTEM ADVANCE IN NOVEL DRUG DELIVERY SYSTEM." International Journal of Current Pharmaceutical Review and Research 14, no. 03 (2022): 118–23. https://doi.org/10.5281/zenodo.12658882.

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The oral route is considered to be the most preferred route for administration of drugs forsystemic effect, but the oral route is not suitable to the administration of drug for lowergastrointestinal (GI) diseases, this happened due to their release at upper GI tract (stomach,small intestine), which further minimizes the accessibility of drugs at the lower GI tract. Toovercome this difficulty, colon-specific drug delivery systems have been broadly analyzedduring the last two decades. Oral delivery of drugs to the colon is valuable in the treatment ofdiseases of colon (ulcerative colitis, Chron'

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J Pavan Kumar, Ranjan Kumar Singh, Chennu MM Prasada Rao, Rajeswari Tannairu, and Ajay Garg. "POLYMERIC NANO-CARRIERS FOR DRUG DELIVERY SYSTEMS IN CANCER THERAPY - AN EXHAUSTIVE REVIEW." Tropical Journal of Pharmaceutical and Life Sciences 12, no. 1 (2025): 33–44. https://doi.org/10.61280/tjpls.v12i1.176.

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Progress in molecular pharmacology and a better comprehension of the mechanism of various diseases have necessitated the precise targeting of the cells responsible for initiating and advancing these diseases. This is particularly applicable to the majority of life-threatening illnesses that necessitate treatment medicines with multiple adverse effects. Therefore, precise tissue targeting is necessary to minimize systemic exposure. Modern drug delivery systems (DDS) are developed utilizing cutting-edge technology to expedite the administration of drugs across the body to a particular target are

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Oluwaseyi Ajibola Fagbemi, Damilola Samuel Ojo-Omoniyi, Festus Ikechukwu Ogbozor, et al. "Biodegradable nanoparticles for targeted drug delivery in viral infections." International Journal of Biological and Pharmaceutical Sciences Archive 9, no. 1 (2025): 048–76. https://doi.org/10.53771/ijbpsa.2025.9.1.0031.

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Viral infections continue to pose significant global health challenges, contributing to high morbidity and mortality rates, as seen in diseases such as HIV/AIDS, hepatitis, influenza, and SARS-CoV-2. Despite advancements in antiviral therapies, conventional treatment strategies face critical limitations, including drug resistance, systemic toxicity, and poor bioavailability. Biodegradable nanoparticles (BNPs) have emerged as revolutionary drug delivery systems, offered targeted and controlled release of antiviral agents while enhanced therapeutic efficacy and minimizing adverse effects. This r

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Wong, Ka Hong, Aiping Lu, Xiaoyu Chen, and Zhijun Yang. "Natural Ingredient-Based Polymeric Nanoparticles for Cancer Treatment." Molecules 25, no. 16 (2020): 3620. http://dx.doi.org/10.3390/molecules25163620.

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Cancer is a global health challenge. There are drawbacks to conventional chemotherapy such as poor bioavailability, development of drug resistance and severe side effects. Novel drug delivery system may be an alternative to optimize therapeutic effects. When such systems consist of natural materials, they offer important advantages: they are usually highly biocompatible, biodegradable, nontoxic and nonimmunogenic. Furthermore, natural materials can be easily modified for conjugation with a wide range of therapeutic agents and targeting ligands, according to the therapeutic purpose. This articl

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Vlachopoulos, Antonios, Georgia Karlioti, Evangelia Balla, et al. "Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances." Pharmaceutics 14, no. 2 (2022): 359. http://dx.doi.org/10.3390/pharmaceutics14020359.

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The sustained release of pharmaceutical substances remains the most convenient way of drug delivery. Hence, a great variety of reports can be traced in the open literature associated with drug delivery systems (DDS). Specifically, the use of microparticle systems has received special attention during the past two decades. Polymeric microparticles (MPs) are acknowledged as very prevalent carriers toward an enhanced bio-distribution and bioavailability of both hydrophilic and lipophilic drug substances. Poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and their copolymers are among

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18

Adnan, Shaikh Jahur, .P. Pawar Sunil, B. Lovhare Rahul., S. Chaudhary Hitendra., and M. Chaudhary Roshan. "A Summary of Polymers Utilized in Novel Drug Delivery System." Journal of Advanced Research and Reviews in Medical & Medicine 1, no. 1 (2024): 38–48. https://doi.org/10.5281/zenodo.10934546.

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<em>Polymer is utilized to create innovative drug delivery systems. Polymers' primary functions are to shield pharmaceuticals from physiological environments and extend their release times to increase their stability.. by disintegration, swelling, and diffusion, the medication is released from the polymer. Numerous polymers, including polymeric hydrogel, microencapsulation, adhesive biomaterial, nanoparticle, polymeric implant, polymeric micelles, liposome, ethosomes, and polymer in therapeutic gene therapy, are being studied for use in innovative drug delivery systems. The idea of drug delive

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19

Bonferoni, Maria Cristina, Elisabetta Gavini, Giovanna Rassu, Marcello Maestri, and Paolo Giunchedi. "Chitosan Nanoparticles for Therapy and Theranostics of Hepatocellular Carcinoma (HCC) and Liver-Targeting." Nanomaterials 10, no. 5 (2020): 870. http://dx.doi.org/10.3390/nano10050870.

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Chitosan nanoparticles are well-known delivery systems widely used as polymeric carriers in the field of nanomedicine. Chitosan is a carbohydrate of natural origin: it is a biodegradable, biocompatible, mucoadhesive, polycationic polymer and it is endowed with penetration enhancer properties. Furthermore, it can be easily derivatized. Hepatocellular carcinoma (HCC) represents a remarkable health problem because current therapies, that include surgery, liver transplantation, trans-arterial embolization, chemoembolization and chemotherapy, present significant limitations due to the high risk of

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Mosqueira, V. C. F., E. A. Leite, C. M. Barros, J. M. C. Vilela, and M. S. Andrade. "Polymeric Nanostructures for Drug Delivery: Characterization by Atomic Force Microscopy." Microscopy and Microanalysis 11, S03 (2005): 36–39. http://dx.doi.org/10.1017/s143192760505083x.

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Formal definitions of nanotechnological devices for drug delivery typically feature the requirements that the device itself or its essential components be man-made, and in the 1-1000 nm range in at least one dimension [1]. The known nanovectors or nanostructures can be filled with drugs for different therapies and for diagnostical aims. Targeting moieties can also be attached to their surface. Polymeric nanovectors are generally made from biodegradable polymers such as polyesters, for example, poly-e-caprolactone (PCL). The drug delivery system known as nanocapsules (NCs) can be defined as a c

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Sobczak, Marcin, and Karolina Kędra. "Biomedical Polyurethanes for Anti-Cancer Drug Delivery Systems: A Brief, Comprehensive Review." International Journal of Molecular Sciences 23, no. 15 (2022): 8181. http://dx.doi.org/10.3390/ijms23158181.

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With the intensive development of polymeric biomaterials in recent years, research using drug delivery systems (DDSs) has become an essential strategy for cancer therapy. Various DDSs are expected to have more advantages in anti-neoplastic effects, including easy preparation, high pharmacology efficiency, low toxicity, tumor-targeting ability, and high drug-controlled release. Polyurethanes (PUs) are a very important kind of polymers widely used in medicine, pharmacy, and biomaterial engineering. Biodegradable and non-biodegradable PUs are a significant group of these biomaterials. PUs can be

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Priti, Pagar* Khushi Borwal Dipali Kothawade pachpute D. S. tufail dana manohar nikam. "Novel Approaches in Herbal Medicine Administration: The Role of Targeted Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 34–49. https://doi.org/10.5281/zenodo.14953664.

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Targeted Drug Delivery Systems (TDDS) represent a promising advancement in the field of herbal medicine, offering the ability to enhance the precision and efficacy of herbal treatments while minimizing side effects. This review explores various innovative approaches for targeted delivery of herbal compounds, including the use of nanoparticles (liposomes, solid lipid nanoparticles, polymeric nanoparticles), microspheres, pH-sensitive systems, and biodegradable polymers. These systems allow for controlled release and protection of herbal bioactive ingredients, facilitating their precise targetin

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Kumar, Sushant, N. V. Satheesh Madhav, Anurag Verma, Kamla Pathak, and Swarnima Pandey. "A Novelistic Biomaterial from Natural Source: its Isolation and Physico-Chemical Characterization." Sumerianz Journal of Medical and Healthcare, no. 41 (March 11, 2021): 35–42. http://dx.doi.org/10.47752/sjmh.41.35.42.

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The objective of this research was to isolate the biomaterial from Juglans regia and explore its different inbuilt polymeric properties by performing different physico-chemical analysis. As we know there are a number of polymers available and frequently used in design and delivery of novel drug targeting tool or carrier systems. But isolated biomaterial from natural source have proved about their novelistic different properties like biodegradable, bioretardant, bioadhesive, filmability etc. These properties are the key factor in design the novel drug targeting tool. So these polymeric properti

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Kumar, Sushant, N. V. Satheesh Madhav, Anurag Verma, Kamla Pathak, and Swarnima Pandey. "A Novelistic Biomaterial from Natural Source: its Isolation and Physico-Chemical Characterization." Sumerianz Journal of Medical and Healthcare, no. 41 (March 11, 2021): 32–39. http://dx.doi.org/10.47752/sjmh.41.32.39.

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The objective of this research was to isolate the biomaterial from Juglans regia and explore its different inbuilt polymeric properties by performing different physico-chemical analysis. As we know there are a number of polymers available and frequently used in design and delivery of novel drug targeting tool or carrier systems. But isolated biomaterial from natural source have proved about their novelistic different properties like biodegradable, bioretardant, bioadhesive, filmability etc. These properties are the key factor in design the novel drug targeting tool. So these polymeric properti

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Zhai, Jingming, Biyu Zhou, Yanhui An, Binzhong Lu, Yonggang Fan, and Junbo Li. "Galactosamine-Conjugating Zwitterionic Block Copolymer for Reduction-Responsive Release and Active Targeted Delivery of Doxorubicin to Hepatic Carcinoma Cells." Journal of Nanomaterials 2020 (April 20, 2020): 1–11. http://dx.doi.org/10.1155/2020/7863709.

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Nanocarriers with integrated advantage, such as excellent stealth property, active targeting function, and rapid intracellular drug release, are significant for cancer treatment. Herein, a biodegradable zwitterionic triblock copolymer containing disulfide-linked poly-ε-caprolactone and polycarboxybetaine methacrylate (PCB-SS-PCL-SS-PCB) was first synthesized and then partly modified with galactosamine (GAL) for constructing polymeric micelle drug carrier with multifunctionality. Polymeric micelles showed ultralow protein absorption in serum and obvious reduction-responsiveness in the presence

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Pagar, Anita H., and Ashish Y. Pawar. "A Birds Eye View on Solid Lipid Nanoparticles and Applications in Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1611–22. http://dx.doi.org/10.25258/ijddt.13.4.75.

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Solid lipid nanoparticles (SLN) might provide fresh opportunities for treating challenging ailments. The SLN were established in the 1990s to replace emulsions and liposomes, in addition to polymeric nanoparticles (NP) as carrier systems. SLN are wet cohesive dispersions with solid biodegradable lipids as their matrices. Drug delivery techniques called SLN use both liquid and solid lipids as their primary matrices. It was demonstrated that SLNs have several benefits over conventional carriers for drug therapy, a longer half-life, tissue-targeted administration, higher permeability, enhanced bi

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Khatode, Sahil* Navale Sonali Kharat Ajit Dr. Jha Urmilesh Dr. Mansuk Avinash. "Oral Disintegrating Tablets Biodegradable Polymers for Drug Delivery." International Journal of Scientific Research and Technology 2, no. 4 (2025): 85–90. https://doi.org/10.5281/zenodo.15170259.

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Biodegradable polymers have emerged as a promising tool for controlled and targeted drug delivery, offering a unique combination of biocompatibility, biodegradability, and versatility. This review article provides a comprehensive overview of recent advances in biodegradable polymers for drug delivery, including natural, synthetic, and hybrid polymers. We discuss the properties and applications of these polymers, including their use in controlled release, targeted delivery, and tissue engineering. Recent advances in nanotechnology, stimuli-responsive polymers, and 3D printing are also highlight

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Moodley, Thashini, and Moganavelli Singh. "Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy." Molecules 25, no. 3 (2020): 742. http://dx.doi.org/10.3390/molecules25030742.

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The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires their critical development to ensure physiological and biological compatibility. Mesoporous silica nanoparticles (MSNs) are attractive nanocarriers due to their biodegradable, biocompatible, and relative malleable porous frameworks that can be functionalized for enhanced targeting and delivery in a variety of disease models. The optimal formulation of

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Duncan, R. "Designing polymer conjugates as lysosomotropic nanomedicines." Biochemical Society Transactions 35, no. 1 (2007): 56–60. http://dx.doi.org/10.1042/bst0350056.

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Marriage of cell biology (the concept of ‘lysosomotropic drug delivery’) and the realization that water-soluble synthetic polymers might provide an ideal platform for targeted drug delivery led to the first synthetic polymer–drug conjugates that entered clinical trials as anticancer agents. Conceptually, polymer conjugates share many features with other macromolecular drugs, but they have the added advantage of the versatility of synthetic chemistry that allows tailoring of molecular mass and addition of biomimetic features. Conjugate characteristics must be optimized carefully to ensure that

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Shokati Eshkiki, Zahra, Fatemeh Mansouri, Amir Reza Karamzadeh, et al. "Chitosan and Its Derivative-Based Nanoparticles in Gastrointestinal Cancers: Molecular Mechanisms of Action and Promising Anticancer Strategies." Journal of Clinical Pharmacy and Therapeutics 2024 (April 5, 2024): 1–19. http://dx.doi.org/10.1155/2024/1239661.

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Gastrointestinal cancers account for a significant health concern as the existing treatment modalities, such as surgery, chemotherapy, and radiation therapy, exhibit considerable drawbacks, including a high probability of recurrence, insufficient drug specificity, and severe adverse effects. Hence, novel therapeutic approaches and enhanced tissue-specific targeting are required. Nanomedicine is a field of medicine that uses nanoscale carriers for targeting and administering drugs or diagnostic agents to particular tissues. In the field of nanomedicine, chitosan nanoparticles are well-establish

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Kole, Eknath, Yogesh Sonar, Rahul J. Sarode, Atul Chaudhari, and Jitendra Naik. "Development and characterisation of lyophilised ethambutol-loaded polymeric nanoparticles." Journal of Applied Pharmaceutical Research 13, no. 2 (2025): 172–80. https://doi.org/10.69857/joapr.v13i2.1093.

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Background: Tuberculosis (TB) remains a universal health crisis, requiring innovative drug delivery systems to overcome challenges like prolonged treatment duration and patient non-adherence. This study was designed to develop Ethambutol (ETH)-loaded poly-ε-caprolactone (PCL) nanoparticles (NPs) as a sustained-release pulmonary delivery platform for TB therapy. Methodology: ETH-PCL NPs were fabricated using the nanoprecipitation technique with Lutrol® F68 as a stabiliser. The formulation was optimised for physicochemical properties (particle size, polydispersity index (PDI), zeta potential), e

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Emami, Jaber, Moloud Kazemi, and Mina Mirian. "Synthesis and in vitro evaluation of self-assembling biocompatible heparin-based targeting polymeric micelles for delivery of doxorubicin to leukemic cells." Research in Pharmaceutical Sciences 20, no. 1 (2025): 142–64. https://doi.org/10.4103/rps.rps_197_24.

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Background and purpose: Biodegradable polymeric micelles have emerged as one of the most promising platforms for targeted drug delivery. In the present study, a polymeric micelle composed of folic acid (FA), heparin (HEP), dexamethasone (DEX), and (FA-PEG-HEP-CA-TOC) was developed for the delivery of doxorubicin (DOX) to leukemic cells. Experimental approach: FA-HEP-DEX was synthesized and characterized by 1H-NMR. DOX-loaded micelles were prepared using a dialysis method. The impact of various processing variables, including polymer-to-drug ratio, dialysis temperature, and solvent type, on the

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Choukaife, Hazem, Abd Almonem Doolaanea, and Mulham Alfatama. "Alginate Nanoformulation: Influence of Process and Selected Variables." Pharmaceuticals 13, no. 11 (2020): 335. http://dx.doi.org/10.3390/ph13110335.

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Nanocarriers are defined as structures and devices that are constructed using nanomaterials which add functionality to the encapsulants. Being small in size and having a customized surface, improved solubility and multi-functionality, it is envisaged that nanoparticles will continue to create new biomedical applications owing to their stability, solubility, and bioavailability, as well as controlled release of drugs. The type and physiochemical as well as morphological attributes of nanoparticles influence their interaction with living cells and determine the route of administration, clearance

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Yadav, Neena, Arul Prakash Francis, Veeraraghavan Vishnu Priya, et al. "Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy." Polymers 14, no. 5 (2022): 950. http://dx.doi.org/10.3390/polym14050950.

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Cancer is one of the most widespread deadly diseases, following cardiovascular disease, worldwide. Chemotherapy is widely used in combination with surgery, hormone and radiation therapy to treat various cancers. However, chemotherapeutic drugs can cause severe side effects due to non-specific targeting, poor bioavailability, low therapeutic indices, and high dose requirements. Several drug carriers successfully overcome these issues and deliver drugs to the desired sites, reducing the side effects. Among various drug delivery systems, polysaccharide-based carriers that target only the cancer c

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Rajshri.R.Dusane, Yogeeta.S.Agrawal Sonia.M.Goyal Kalyani.A.Chaudhari. "A REVIEW ARTICLE ON NANOSTRUCTURED LIPID CARRIERS (NLCS) FOR DRUG DELIVERY AND TARGETING SYSTEM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 05 (2019): 9568–77. https://doi.org/10.5281/zenodo.2819849.

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<em>During the past decade, the number of studies describing nanostructured lipid carriers (NLC)-based formulations has been dramatically increased. The raise in NLC exploitation is essentially due to defeated barriers within the technological process of lipid-based nanoparticles’ formulation and increased knowledge of the underlying mechanisms of transport of NLC via different routes of administration. This review article aims to give an overview on the current state of the art of nanostructured lipid carriers as controlled drug delivery systems for future clinics through novel NLC appl

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Agiba, Ahmed M., Nihal Elsayyad, Hala N. ElShagea, et al. "Advances in Light-Responsive Smart Multifunctional Nanofibers: Implications for Targeted Drug Delivery and Cancer Therapy." Pharmaceutics 16, no. 8 (2024): 1017. http://dx.doi.org/10.3390/pharmaceutics16081017.

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Over the last decade, scientists have shifted their focus to the development of smart carriers for the delivery of chemotherapeutics in order to overcome the problems associated with traditional chemotherapy, such as poor aqueous solubility and bioavailability, low selectivity and targeting specificity, off-target drug side effects, and damage to surrounding healthy tissues. Nanofiber-based drug delivery systems have recently emerged as a promising drug delivery system in cancer therapy owing to their unique structural and functional properties, including tunable interconnected porosity, a hig

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S., Nikam Supriya, Phadatare Priya P., Watode Ankita B., and Kalyani Kayande. "NANOSTRUCTURED LIPID CARRIERS: A PROMISING APPROACH FOR TOPICAL DRUG DELIVERY SYSTEM." International Journal of Pharmaceutical Sciences and Medicine 6, no. 7 (2021): 81–101. http://dx.doi.org/10.47760/ijpsm.2021.v06i07.007.

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Nanostructured lipid carriers (NLCs) are innovative pharmaceutical formulations made up of physiological and biocompatible lipids, as well as surfactants and co-surfactant. The initial generation of lipid nanoparticles was Solid Lipid Nanoparticles (SLN), which had a longer-lasting activity and was better, suited to drug penetration. The NLC is a second-generation lipid nanoparticle designed to alleviate the limitations of SLN, such as limited drug loading capacity and solid lipid polymorphism. Many benefits of topical medication delivery include avoiding first-pass metabolism, focusing active

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Kántor, Izolda, Diana Dreavă, Anamaria Todea та ін. "Co-Entrapment of Sorafenib and Cisplatin Drugs and iRGD Tumour Homing Peptide by Poly[ε-caprolactone-co-(12-hydroxystearate)] Copolymer". Biomedicines 10, № 1 (2021): 43. http://dx.doi.org/10.3390/biomedicines10010043.

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The drug-loaded nanocarriers have overcome various challenges compared with the pure chemotherapeutic drug, such as limited bioavailability, multiple drug resistance, poor patient compliance, and adverse drug reactions, offering advantages such as protection from degradation in the blood stream, better drug solubility, and improved drug stability. One promising group of controlled and targeted drug delivery systems is polymer-based nanoparticles that can sustain the release of the active agent by diffusion and their degradation. Sorafenib is the only drug that can prolong the life of patients

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Manek, Eniko, Ferenc Darvas, and Georg A. Petroianu. "Use of Biodegradable, Chitosan-Based Nanoparticles in the Treatment of Alzheimer’s Disease." Molecules 25, no. 20 (2020): 4866. http://dx.doi.org/10.3390/molecules25204866.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects more than 24 million people worldwide and represents an immense medical, social and economic burden. While a vast array of active pharmaceutical ingredients (API) is available for the prevention and possibly treatment of AD, applicability is limited by the selective nature of the blood-brain barrier (BBB) as well as by their severe peripheral side effects. A promising solution to these problems is the incorporation of anti-Alzheimer drugs in polymeric nanoparticles (NPs). However, while several polymeric NPs are

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Vijay, Yadav Riyajul Ansari Ayush Gandhi Indu Passi*. "Nanomedicine-Based Approaches for Treatment of Ocular Diseases." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1132–40. https://doi.org/10.5281/zenodo.15016934.

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Nanomedicine is a new frontier in the treatment of eye diseases with disruptive novelty, from overcoming unique anatomical and physiological barriers that historically impeded drug delivery to the eye. Most ocular diseases, such as glaucoma, AMD, diabetic retinopathy, and uveitis, pose serious challenges to treatment as a result of their complex anatomy and protective mechanisms limiting drug penetration and retention. These old and conventional forms, such as eye drops and ointments, cannot achieve the desired therapeutic concentrations at the target site; hence, efficacy is likely to be comp

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Genedy, Hussein H., Thierry Delair, and Alexandra Montembault. "Chitosan Based MicroRNA Nanocarriers." Pharmaceuticals 15, no. 9 (2022): 1036. http://dx.doi.org/10.3390/ph15091036.

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Vectorization of microRNAs has shown to be a smart approach for their potential delivery to treat many diseases (i.e., cancer, osteopathy, vascular, and infectious diseases). However, there are barriers to genetic in vivo delivery regarding stability, targeting, specificity, and internalization. Polymeric nanoparticles can be very promising candidates to overcome these challenges. One of the most suitable polymers for this purpose is chitosan. Chitosan (CS), a biodegradable biocompatible natural polysaccharide, has always been of interest for drug and gene delivery. Being cationic, chitosan ca

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M.Rashid, Asmaa, and Mowafaq M. Ghareeb. "Using ionic Liquids-Based Surfactant in formulating Nimodipine Polymeric Nanoparticles: A Promising Approach for Improved Performance." Iraqi Journal of Pharmaceutical Sciences 34, no. 1 (2025): 203–17. https://doi.org/10.31351/vol34iss1pp203-217.

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According to definition, polymeric nanoparticles (NP) exist as tiny, solid, colloidal particles ranging from 1-1000 nm in size, manufactured from biodegradable and biocompatible polymers, lipids, or metals. Polymeric nanoparticles have attracted substantial attention in various fields, including imaging, and diagnostics, and considered as interesting choices for drug delivery and targeting. The synthesis and stabilization of nanoparticles are crucial for their successful application. Ionic Liquids-Based Surfactants (ILBS) have emerged as promising solvents and stabilizers owing to their distin

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Sadhana, R. Shahi, Dhum Vijaya, watane Pooja, and S. Kale Priyanka. "Review On In-Situ Gel For Nasal Drug Delivery." AMERICAN JOURNAL OF PHARMACY AND HEALTH RESEARCH 11, no. 02 (2023): 18–36. https://doi.org/10.5281/zenodo.7807848.

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ABSTRACT The oral route is a strategy that has been in use for many years. Although it is the most popular and widely used method for giving drugs to people orally, various restrictions, such as drug absorption or drug targeting to a specific <sup>1</sup>organ, might make it difficult to administer... To address these issues as well as to advance medication development security and effectiveness In-situ Nasal Delivery is a unique method for medication delivery system for delivering drugs. The medication used in nasal gels is given as a low viscosity solution. The nasal mucosa when in contact w

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Arshady, Reza. "Review : Biodegradable Microcapsular Drug Delivery Systems: Manufacturing Methodology, Release Control and Targeting Prospects." Journal of Bioactive and Compatible Polymers 5, no. 3 (1990): 315–42. http://dx.doi.org/10.1177/088391159000500308.

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Ding, Ling, Prachi Agrawal, Sandeep K. Singh, Yashpal S. Chhonker, Jingjing Sun, and Daryl J. Murry. "Polymer-Based Drug Delivery Systems for Cancer Therapeutics." Polymers 16, no. 6 (2024): 843. http://dx.doi.org/10.3390/polym16060843.

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Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic methods for treating cancer. However, the off-target effects of chemotherapy are known to produce side effects and dose-limiting toxicities. Novel delivery platforms based on natural and synthetic polymers with enhanced pharmacokinetic and therapeutic potential for the treatment of cancer have grown tremendously over the past 10 years. Polymers can facilitate selective targeting, enhance and prolong circulation, improve delivery, and provide the controlled release of cargos through various mechanisms, includ

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Ruirui, Zhang, Jian He, Ximei Xu, et al. "PLGA-based drug delivery system for combined therapy of cancer: research progress." Materials Research Express 8, no. 12 (2021): 122002. http://dx.doi.org/10.1088/2053-1591/ac3f5e.

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Abstract In recent years, PLGA micro/nano particle drug delivery systems has been widely used in cancer treatment. According to the unique properties of PLGA, carriers of various structures are designed to keep the function of drugs or bioactive substances, ensure the effective load of molecules and improve the bioavailability of drugs in diseased parts. PLGA is one of the earliest and most commonly used biodegradable materials. It is often used for functional modification with other polymers (such as polyethylene glycol and chitosan) or other molecules (such as aptamers and ligands) to delive

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Yuan, Shuang, Dai Qian, and Wanyun Su. "Fabrication of co-polymeric nanoformulation loaded with antibiotic ofloxacin and immunosuppressant tacrolimus for pediatric sepsis-induced acute lung injury." Materials Express 13, no. 7 (2023): 1192–202. http://dx.doi.org/10.1166/mex.2023.2466.

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Sepsis is a complicated, life-threatening illness caused by pathogen invasion triggered by a dysfunctional immune system in the host. Even though several antimicrobial and immunosuppressive therapies have been suggested, no clinically viable treatments for sepsis exist. This research aims to find a way to cure sepsis and reduce its symptoms by creating a nanoparticle system that specifically targets inflammation and drug delivery sites. To fabricate the PLGA-NPs loaded with the wide-range antibiotic Ofloxacin (OFX) and the immunosuppressant anti-inflammatory Tacrolimus (TCR), we opted for the

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Hreczuk-Hirst, Dale, Lisa German, and Ruth Duncan. "Dextrins as Carriers for Drug Targeting: Reproducible Succinoylation as a Means to Introduce Pendant Groups." Journal of Bioactive and Compatible Polymers 16, no. 5 (2001): 353–65. http://dx.doi.org/10.1106/qbky-e3vm-19k4-3ga5.

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Dextrin (a-1,4 polyglucose) is in clinical use as a peritoneal dialysis solution and controlled drug delivery formulation. As a biodegradable polymer, dextrin has considerable potential as a polymeric drug carrier. Succinoylation, using dimethylaminopyridine (DMAP) as a catalyst, was used to conjugate chemotherapeutic agents, probes to follow biodistribution and probes to monitor intracellular fate. The aims of this study were to optimize the reaction conditions for the succinoylation (in respect of temperature and reaction time), to assess the suitability of succinoylated-dextrin as an interm

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Khiewkamrop, Phuriwat, Chamraj Kaewraemruaen, Chonnavee Manipuntee, et al. "Immunosuppressive Polymeric Nanoparticles Targeting Dendritic Cells Alleviate Lupus Disease in Fcgr2b−/− Mice by Mediating Antigen-Specific Immune Tolerance." International Journal of Molecular Sciences 24, no. 9 (2023): 8313. http://dx.doi.org/10.3390/ijms24098313.

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Dendritic cells (DCs) are the most potent antigen-presenting cells that have multifaceted functions in the control of immune activation and tolerance. Hyperresponsiveness and altered tolerogenicity of DCs contribute to the development and pathogenesis of system lupus erythematosus (SLE); therefore, DC-targeted therapies aimed at inducing specific immune tolerance have become of great importance for the treatment of SLE. This study developed a new nanoparticle (NP) containing a biodegradable PDMAEMA-PLGA copolymer for target-oriented delivery to DCs in situ. PDMAEMA-PLGA NPs provided sustained

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Abo El-Enin, Hadel A., Marwa F. Ahmed, Ibrahim A. Naguib, et al. "Utilization of Polymeric Micelles as a Lucrative Platform for Efficient Brain Deposition of Olanzapine as an Antischizophrenic Drug via Intranasal Delivery." Pharmaceuticals 15, no. 2 (2022): 249. http://dx.doi.org/10.3390/ph15020249.

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Schizophrenia is a mental disorder characterized by alterations in cognition, behavior and emotions. Oral olanzapine (OZ) administration is extensively metabolized (~up to 40% of the administrated dose). In addition, OZ is a P-glycoproteins substrate that impairs the blood–brain barrier (BBB) permeability. To direct OZ to the brain and to minimize its systemic side effects, the nasal pathway is recommended. OZ-loaded polymeric micelles nano-carriers were developed using suitable biodegradable excipients. The developed micelles were physicochemically investigated to assess their appropriateness

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