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Journal articles on the topic 'Delta inulin'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Afinjuomo, Franklin, Thomas G. Barclay, Ankit Parikh, et al. "Design and Characterization of Inulin Conjugate for Improved Intracellular and Targeted Delivery of Pyrazinoic Acid to Monocytes." Pharmaceutics 11, no. 5 (2019): 243. http://dx.doi.org/10.3390/pharmaceutics11050243.

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The propensity of monocytes to migrate into sites of mycobacterium tuberculosis (TB) infection and then become infected themselves makes them potential targets for delivery of drugs intracellularly to the tubercle bacilli reservoir. Conventional TB drugs are less effective because of poor intracellular delivery to this bacterial sanctuary. This study highlights the potential of using semicrystalline delta inulin particles that are readily internalised by monocytes for a monocyte-based drug delivery system. Pyrazinoic acid was successfully attached covalently to the delta inulin particles via a

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2

Honda-Okubo, Yoshikazu, Dale Barnard, Chun Hao Ong, Bi-Hung Peng, Chien-Te Kent Tseng, and Nikolai Petrovsky. "Severe Acute Respiratory Syndrome-Associated Coronavirus Vaccines Formulated with Delta Inulin Adjuvants Provide Enhanced Protection while Ameliorating Lung Eosinophilic Immunopathology." Journal of Virology 89, no. 6 (2014): 2995–3007. http://dx.doi.org/10.1128/jvi.02980-14.

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ABSTRACTAlthough the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) epidemic was controlled by nonvaccine measures, coronaviruses remain a major threat to human health. The design of optimal coronavirus vaccines therefore remains a priority. Such vaccines present major challenges: coronavirus immunity often wanes rapidly, individuals needing to be protected include the elderly, and vaccines may exacerbate rather than prevent coronavirus lung immunopathology. To address these issues, we compared in a murine model a range of recombinant spike protein or inactivated whole-vir

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3

Wang, Lixin, Thomas Barclay, Yunmei Song, et al. "Investigation of the biodistribution, breakdown and excretion of delta inulin adjuvant." Vaccine 35, no. 34 (2017): 4382–88. http://dx.doi.org/10.1016/j.vaccine.2017.06.045.

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4

Ferrell, Kia C., Erica L. Stewart, Claudio Counoupas, et al. "Intrapulmonary vaccination with delta-inulin adjuvant stimulates non-polarised chemotactic signalling and diverse cellular interaction." Mucosal Immunology 14, no. 3 (2021): 762–73. http://dx.doi.org/10.1038/s41385-021-00379-6.

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AbstractThere is an urgent need for novel vaccination strategies to combat respiratory pathogens. Mucosal vaccine delivery is an attractive option as it directly targets the site of infection; however, preclinical development has been hindered by a lack of suitable mucosal adjuvants and a limited understanding of their immune effects in the lung environment. Herein, we define the early immune events following the intrapulmonary delivery of a vaccine incorporating the adjuvant delta-inulin. Analysis of the early inflammatory response showed vaccine-induced innate cell recruitment to lungs and l

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5

Murugappan, Senthil, Henderik W. Frijlink, Nikolai Petrovsky, and Wouter L. J. Hinrichs. "Enhanced pulmonary immunization with aerosolized inactivated influenza vaccine containing delta inulin adjuvant." European Journal of Pharmaceutical Sciences 66 (January 2015): 118–22. http://dx.doi.org/10.1016/j.ejps.2014.10.008.

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6

Wang, Lixin, Yunmei Song, Ankit Parikh, et al. "Doxorubicin-Loaded Delta Inulin Conjugates for Controlled and Targeted Drug Delivery: Development, Characterization, and In Vitro Evaluation." Pharmaceutics 11, no. 11 (2019): 581. http://dx.doi.org/10.3390/pharmaceutics11110581.

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Delta inulin, also known as microparticulate inulin (MPI), was modified by covalently attaching doxorubicin to its nanostructured surface for use as a targeted drug delivery vehicle. MPI is readily endocytosed by monocytes, macrophages, and dendritic cells and in this study, we sought to utilize this property to develop a system to target anti-cancer drugs to lymphoid organs. We investigated, therefore, whether MPI could be used as a vehicle to deliver doxorubicin selectively, thereby reducing the toxicity of this antibiotic anthracycline drug. Doxorubicin was covalently attached to the surfac

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7

Heddle, Robert, Paul Russo, Nikolai Petrovsky, Rory Hanna, and Anthony Smith. "Immunotherapy – 2076. A controlled study of delta inulin-adjuvanted honey bee venom immunotherapy." World Allergy Organization Journal 6 (2013): P158. http://dx.doi.org/10.1186/1939-4551-6-s1-p158.

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8

Hayashi, Masayuki, Taiki Aoshi, Yasunari Haseda, et al. "Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines." EBioMedicine 15 (February 2017): 127–36. http://dx.doi.org/10.1016/j.ebiom.2016.11.015.

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9

LUCACI, ANCA IOANA, SIMONA NEAGU, ROXANA COJOC, ROBERT RUGINESCU, IOAN ARDELEAN, and MĂDĂLIN ENACHE. "Benefits of understanding the enzymatic activities in saline Lake Letea in the Danube Delta." Romanian Biotechnological Letters 26, no. 2 (2021): 2448–54. http://dx.doi.org/10.25083/rbl/26.2/2448.2454.

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The purpose of this paper was to isolate halophiles from Letea saline lake and to performed a screening for industrially relevant extracellular enzymes. The investigations were conducted from October 2016 until May 2018. After a random selection of colonies that grew on the medium culture, 82 isolates were investigated. Based on their salt requirements and tolerance, it was remarked the presence of isolates belonging to halotolerant and moderate halophilic bacteria. Morphological and biochemical tests were used to characterize them. The ability of the tested isolates to produce extracellular e

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10

Roberts, M., M. D. Lindheimer, and J. M. Davison. "Altered glomerular permselectivity to neutral dextrans and heteroporous membrane modeling in human pregnancy." American Journal of Physiology-Renal Physiology 270, no. 2 (1996): F338—F343. http://dx.doi.org/10.1152/ajprenal.1996.270.2.f338.

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Hyperfiltration precedes renal function loss in several nephropathies. Animal studies suggest this may be due to accompanying increases in transglomerular capillary hydrostatic pressure difference (delta P) and/or altered glomerular processing of macromolecules. Renal hemodynamics increase strikingly in human pregnancy. To test the hypothesis that these alterations are not potentially harmful, clearances of inulin, p-aminohippurate, and neutral dextrans were measured at 16- and 36-wk gestation, then 4 mo postpartum, in 11 normotensive women. Results were analyzed using two computer modeling pr

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11

Honda-Okubo, Yoshikazu, Chun Hao Ong, and Nikolai Petrovsky. "Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection." Vaccine 33, no. 38 (2015): 4892–900. http://dx.doi.org/10.1016/j.vaccine.2015.07.051.

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12

Heddle, Robert, Anthony Smith, Richard Woodman, Pravin Hissaria, and Nikolai Petrovsky. "Randomized controlled trial demonstrating the benefits of delta inulin adjuvanted immunotherapy in patients with bee venom allergy." Journal of Allergy and Clinical Immunology 144, no. 2 (2019): 504–13. http://dx.doi.org/10.1016/j.jaci.2019.03.035.

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13

Gordon, David L., Dimitar Sajkov, Yoshikazu Honda-Okubo, et al. "Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant." Vaccine 34, no. 33 (2016): 3780–86. http://dx.doi.org/10.1016/j.vaccine.2016.05.071.

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14

Honda-Okubo, Yoshikazu, Harinda Rajapaksha, Dimitar Sajkov, David Gordon, Manon M. J. Cox, and Nikolai Petrovsky. "Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of a delta inulin adjuvanted recombinant pandemic influenza vaccine." Human Vaccines & Immunotherapeutics 13, no. 6 (2017): 1261–71. http://dx.doi.org/10.1080/21645515.2017.1279765.

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15

Layton, R. Colby, Nikolai Petrovsky, Andrew P. Gigliotti, et al. "Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets." Vaccine 29, no. 37 (2011): 6242–51. http://dx.doi.org/10.1016/j.vaccine.2011.06.078.

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16

Cooper, P. D., and N. Petrovsky. "Delta inulin: a novel, immunologically active, stable packing structure comprising -D-[2 -> 1] poly(fructo-furanosyl) -D-glucose polymers." Glycobiology 21, no. 5 (2010): 595–606. http://dx.doi.org/10.1093/glycob/cwq201.

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17

Petrovsky, Nikolai, and Peter D. Cooper. "Advax™, a novel microcrystalline polysaccharide particle engineered from delta inulin, provides robust adjuvant potency together with tolerability and safety." Vaccine 33, no. 44 (2015): 5920–26. http://dx.doi.org/10.1016/j.vaccine.2015.09.030.

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18

Cooper, P. D., T. G. Barclay, M. Ginic-Markovic, and N. Petrovsky. "Gamma ray sterilization of delta inulin adjuvant particles (Advax™) makes minor, partly reversible structural changes without affecting adjuvant activity." Vaccine 32, no. 5 (2014): 552–57. http://dx.doi.org/10.1016/j.vaccine.2013.11.105.

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19

Bakris, G. L., U. Starke, M. Heifets, D. Polack, M. Smith, and S. Leurgans. "Renal effects of oral prostaglandin supplementation after ibuprofen in diabetic subjects: a double-blind, placebo-controlled, multicenter trial." Journal of the American Society of Nephrology 5, no. 9 (1995): 1684–88. http://dx.doi.org/10.1681/asn.v591684.

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Prostaglandins of the E series (PGE) are known to contribute to the maintenance of renal hemodynamics in subjects with chronic renal insufficiency. Agents that block PGE synthesis, nonsteroidal anti-inflammatory agents (NSAID), are widely used by people with renal insufficiency. This study was undertaken in subjects with renal insufficiency secondary to diabetes to evaluate the acute effects of a PGE1 analog, misoprostol, on NSAID-induced changes in RBF, as calculated by para-aminohippurate clearance, and GFR, as calculated by inulin clearance. Sodium excretion was also assessed. Twenty-five f

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20

Walters, E. A., L. Rome, R. G. Luke, and J. H. Galla. "Absence of a regulatory role of angiotensin II in acute chloride-depletion alkalosis in rats." American Journal of Physiology-Renal Physiology 261, no. 5 (1991): F741—F745. http://dx.doi.org/10.1152/ajprenal.1991.261.5.f741.

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Chloride-depletion alkalosis (CDA) has been characterized by hypereninemia. To determine whether angiotensin II (ANG II) has an important role in its maintenance or correction, anesthetized alkalotic rats, chloride depleted by peritoneal dialysis, were infused with 5% dextrose and saralasin (1 microgram.kg-1.min-1) (SAR) or vehicle (SAR-C), 5% dextrose and pretreatment with enalapril (1-1.5 mg/kg) (ENP) or vehicle (ENP-C), or 80 mM Cl solution with ANG II (20 micrograms/min) (ANG) or vehicle (ANG-C). Rats infused with 5% dextrose showed no differences in the magnitude of the alkalosis, inulin

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21

Wong, Terianne M., Nikolai Petrovsky, Stephanie J. Bissel, Clayton A. Wiley, and Ted M. Ross. "Delta inulin-derived adjuvants that elicit Th1 phenotype following vaccination reduces respiratory syncytial virus lung titers without a reduction in lung immunopathology." Human Vaccines & Immunotherapeutics 12, no. 8 (2016): 2096–105. http://dx.doi.org/10.1080/21645515.2016.1162931.

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22

Honda-Okubo, Yoshikazu, Fadi Saade, and Nikolai Petrovsky. "Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses." Vaccine 30, no. 36 (2012): 5373–81. http://dx.doi.org/10.1016/j.vaccine.2012.06.021.

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23

Menon, Veena, Victor I. Ayala, Sneha P. Rangaswamy, et al. "DNA prime/protein boost vaccination elicits robust humoral response in rhesus macaques using oligomeric simian immunodeficiency virus envelope and Advax delta inulin adjuvant." Journal of General Virology 98, no. 8 (2017): 2143–55. http://dx.doi.org/10.1099/jgv.0.000863.

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24

Li, Lei, Yoshikazu Honda-Okubo, Connie Li, Dimitar Sajkov, and Nikolai Petrovsky. "Delta Inulin Adjuvant Enhances Plasmablast Generation, Expression of Activation-Induced Cytidine Deaminase and B-Cell Affinity Maturation in Human Subjects Receiving Seasonal Influenza Vaccine." PLOS ONE 10, no. 7 (2015): e0132003. http://dx.doi.org/10.1371/journal.pone.0132003.

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25

Honda-Okubo, Yoshikazu, Annasaheb Kolpe, Lei Li, and Nikolai Petrovsky. "A single immunization with inactivated H1N1 influenza vaccine formulated with delta inulin adjuvant (Advax™) overcomes pregnancy-associated immune suppression and enhances passive neonatal protection." Vaccine 32, no. 36 (2014): 4651–59. http://dx.doi.org/10.1016/j.vaccine.2014.06.057.

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26

Rodriguez-Del Rio, Estela, Marco Marradi, Ricardo Calderon-Gonzalez, et al. "A gold glyco-nanoparticle carrying a listeriolysin O peptide and formulated with Advax™ delta inulin adjuvant induces robust T-cell protection against listeria infection." Vaccine 33, no. 12 (2015): 1465–73. http://dx.doi.org/10.1016/j.vaccine.2015.01.062.

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27

Lee, Youri, Eun-Ju Ko, Young-Tae Lee, Ki-Hye Kim, Young-Man Kwon, and Sang-Moo Kang. "A unique adjuvant combination modulates immune responses preventing vaccine-enhanced pulmonary histopathology after vaccination with fusion protein and challenge with respiratory syncytial virus." Journal of Immunology 200, no. 1_Supplement (2018): 180.28. http://dx.doi.org/10.4049/jimmunol.200.supp.180.28.

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Abstract Vaccination of young children with alum-adjuvanted formalin-inactivated respiratory syncytial virus (FI-RSV) induced vaccine-enhanced disease (VED) after natural infection during epidemic season, resulting in hospitalizations and two deaths. There is no licensed RSV vaccine. VED was also observed in previous reports with fusion (F) protein RSV vaccines and adjuvants including oil-in-water emulsion, delta-inulin, and natural killer T cell agonist α-GalCer. In this study to search for adjuvants preventing RSV VED, we investigated a novel combination of monophosphoryl lipid A (MPL TLR4 a

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28

Gordon, David, Peter Kelley, Susanne Heinzel, Peter Cooper, and Nikolai Petrovsky. "Immunogenicity and safety of Advax™, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: A randomized controlled Phase 1 study." Vaccine 32, no. 48 (2014): 6469–77. http://dx.doi.org/10.1016/j.vaccine.2014.09.034.

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29

Saade, Fadi, Yoshikazu Honda-Okubo, Samay Trec, and Nikolai Petrovsky. "A novel hepatitis B vaccine containing Advax™, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing." Vaccine 31, no. 15 (2013): 1999–2007. http://dx.doi.org/10.1016/j.vaccine.2012.12.077.

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30

de Paula Oliveira Santos, Bruno, Monalisa Martins Trentini, Renato Beilner Machado, et al. "Advax4 delta inulin combination adjuvant together with ECMX, a fusion construct of four protective mTB antigens, induces a potent Th1 immune response and protects mice against Mycobacterium tuberculosis infection." Human Vaccines & Immunotherapeutics 13, no. 12 (2017): 2967–76. http://dx.doi.org/10.1080/21645515.2017.1368598.

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31

Komiya, Tomoyoshi, Yoshikazu Honda-Okubo, Jeremy Baldwin, and Nikolai Petrovsky. "An Advax-Adjuvanted Inactivated Cell-Culture Derived Japanese Encephalitis Vaccine Induces Broadly Neutralising Anti-Flavivirus Antibodies, Robust Cellular Immunity and Provides Single Dose Protection." Vaccines 9, no. 11 (2021): 1235. http://dx.doi.org/10.3390/vaccines9111235.

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ccJE+Advax is an inactivated cell culture Japanese encephalitis (JE) vaccine formulated with Advax, a novel polysaccharide adjuvant based on delta inulin. This vaccine has previously shown promise in murine and equine studies and the current study sought to better understand its mechanism of action and assess the feasibility of single dose vaccine protection. Mice immunised with ccJE+Advax had higher serum neutralisation titres than those immunised with ccJE alone or with alum adjuvant. ccJE+Advax induced extraordinarily broad cross-neutralising antibodies against multiple flaviviruses includi

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32

Petrovsky, N., M. Larena, V. Siddharthan, et al. "An Inactivated Cell Culture Japanese Encephalitis Vaccine (JE-ADVAX) Formulated with Delta Inulin Adjuvant Provides Robust Heterologous Protection against West Nile Encephalitis via Cross-Protective Memory B Cells and Neutralizing Antibody." Journal of Virology 87, no. 18 (2013): 10324–33. http://dx.doi.org/10.1128/jvi.00480-13.

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33

Stronsky, Sabrina M., Christopher L. Cooper, Jesse Steffens, et al. "Adjuvant selection impacts the correlates of vaccine protection against Ebola infection." Vaccine 38, no. 29 (2020): 4601–8. https://doi.org/10.5281/zenodo.13537717.

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(Uploaded by Plazi for the Bat Literature Project) The establishment of correlates of protection is particularly relevant in the context of rare, highly lethal pathogens such as filoviruses. We previously demonstrated that an Ebola glycoprotein virus-like particle (VLP) vaccine, when given as two intramuscular doses, conferred protection from challenge in a murine challenge model. In this study, we compared the ability of Advax inulin-based adjuvant formulations (Advax1-4) to enhance Ebola VLP vaccine protection in mice. After two immunizations, Advax-adjuvants that included a TLR9 agonist com

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34

Stronsky, Sabrina M., Christopher L. Cooper, Jesse Steffens, et al. "Adjuvant selection impacts the correlates of vaccine protection against Ebola infection." Vaccine 38, no. 29 (2020): 4601–8. https://doi.org/10.5281/zenodo.13537717.

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(Uploaded by Plazi for the Bat Literature Project) The establishment of correlates of protection is particularly relevant in the context of rare, highly lethal pathogens such as filoviruses. We previously demonstrated that an Ebola glycoprotein virus-like particle (VLP) vaccine, when given as two intramuscular doses, conferred protection from challenge in a murine challenge model. In this study, we compared the ability of Advax inulin-based adjuvant formulations (Advax1-4) to enhance Ebola VLP vaccine protection in mice. After two immunizations, Advax-adjuvants that included a TLR9 agonist com

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35

Habre, W., M. Beghetti, C. Roduit, et al. "Haemodynamic and Renal Effects of Dopexamine after Cardiac Surgery in Children." Anaesthesia and Intensive Care 24, no. 4 (1996): 435–39. http://dx.doi.org/10.1177/0310057x9602400404.

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Dopexamine hydrochloride, a synthetic dopamine analog with predominantly beta and delta agonist properties, has been shown to improve cardiac performance and renal function in adults with heart failure. This study was designed to investigate the haemodynamic and renal effects of dopexamine in children after cardiac surgery. Seven children were selected in whom a need for postoperative vasodilation after cardiac surgery was anticipated. Haemodynamics and renal function were determined under baseline conditions and during a continuous infusion of dopexamine at 2 and 6 μg.kg-1.min-1 for 90 minute

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36

Burn, C. R. "The hydrologic regime of Mackenzie River and connection of "no-closure" lakes to distributary channels in the Mackenzie Delta, Northwest Territories." Canadian Journal of Earth Sciences 32, no. 7 (1995): 926–37. http://dx.doi.org/10.1139/e95-078.

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Mackenzie Delta lakes have been classified by the seasonal duration of their connection to Mackenzie River. "No-closure" lakes are determined on the basis of minimum summer water level. Such lakes may become disconnected from the Mackenzie in autumn or winter, as water level falls or if the sills between lakes and distributary channels are frozen through and so sealed. Water level in the central delta rises continuously after late November–early December, at first because discharge into the delta increases once the Mackenzie drainage basin has frozen over, and then as sea and channel ice thick

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37

Rusek, J. "Blissia glabra gen.n., sp.n. (Collembola: Isotomidae) from northwestern Canada." Canadian Journal of Zoology 63, no. 9 (1985): 2077–82. http://dx.doi.org/10.1139/z85-305.

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Blissia glabra, a new genus and species from the Mackenzie River Delta south of Inuvik, N.W.T., is described. The new genus is related to Tetracanthella Schött, 1891 (Isotomidae). Morphological characters as seen with light and scanning electron microscopes are described and figured.

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38

Ustjuzhanin, P. Ya, V. V. Dubatolov, and A. N. Streltzov. "Pterophoridae de la Gran Isla Bolshoy Ussuriysky (suburbios de Khabarovsk), Rusia (Lepidoptera: Pterophoroidea)." SHILAP Revista de lepidopterología 48, no. 189 (2020): 27–30. http://dx.doi.org/10.57065/shilap.405.

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Se registran 12 especies de Pterophoridae de la Gran Isla Bolshoy Ussuriysky (suburbios de Khabarovsk), en el delta del Ussuri; la mayoría de ellos prefieren praderas mesófitas. Dos especies, Agdistis adactyla (Hübner, [1823]) y Hellinsia inulae (Zeller, 1852) prefieren localidades secas y no eran conocidas del este de Khabarovsk.

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39

Fort, Tim. "Oklahoma in Inuvik." Canadian Theatre Review 72 (September 1992): 31–33. http://dx.doi.org/10.3138/ctr.72.006.

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In the spring of 1988, I was invited to spend a week staging a play with a senior drama class at a high school in Inuvik, NWT. The class, a majority of whom were Inuit teenagers, worked up a story involving snowmobiles, bar fights, and rip-offs of the Bay company – ending with a moral pronouncement about the difficulties of leaving the bush for the town. Rehearsing in scruffy jeans and AC / DC T-shirts, the group acted no differently than any other collection of high school students trying to cruise through the long last period of the day, but they improvised their assortment of local vignette

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40

Toda, Masanori J. "HABITAT STRUCTURE OF A DROSOPHILID COMMUNITY AT INUVIK, NWT, CANADA (DIPTERA: DROSOPHILIDAE)." Canadian Entomologist 117, no. 1 (1985): 135–37. http://dx.doi.org/10.4039/ent117135-1.

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The northern subarctic region is the limit of the distribution of Drosophilidae (Toda 1984); the family is of tropical origin (Throckmorton 1975). Hence, a drosophilid community inhabiting the northernmost subarctic region is likely to have a relatively simple community structure. This note presents information on the habitat preferences of a drosophilid community at Inuvik (68°22′ N, 133°45′ W) in the Mackenzie delta, Northwest Territories, Canada.

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41

Hill, Philip R. "Late Quaternary sequence stratigraphy of the Mackenzie Delta." Canadian Journal of Earth Sciences 33, no. 7 (1996): 1053–74. http://dx.doi.org/10.1139/e96-081.

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The Late Wisconsinan and Holocene sequence stratigraphy of the Mackenzie Delta provides insights into the glacial history of the region. The base of the described succession is a hummocky regional reflector interpreted to be a flooding surface formed immediately after retreat of glacial ice from the Mackenzie Trough. Above this flooding surface, two progradational parasequences are present. The first, assigned to the transgressive systems tract, is correlated with the Tutsieta Lake readvance of the ice sheet at approximately 13 000 BP. A flooding surface forming the upper boundary of this para

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42

KINGHORN, APRIL, MURRAY HUMPHRIES, PETER OUTRIDGE, and HING MAN CHAN. "RECONSTRUCTING HISTORICAL MERCURY EXPOSURE FROM BELUGA WHALE CONSUMPTION AMONG INUIT IN THE MACKENZIE DELTA." Journal of Ethnobiology 26, no. 2 (2006): 310–26. http://dx.doi.org/10.2993/0278-0771(2006)26[310:rhmefb]2.0.co;2.

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43

Kinghorn, April, Murray Humphries, Peter Outridge, and Hing Man Chan. "Reconstructing Historical Mercury Exposure from Beluga Whale Consumption among Inuit in the Mackenzie Delta." Journal of Ethnobiology 26, no. 2 (2006): 310–26. http://dx.doi.org/10.2993/0278-0771_2006_26_310_rhmefb_2.0.co_2.

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Modern increases in mercury levels in Arctic marine mammals have important implications for people who consume these resources as part of a traditional diet. This paper establishes estimates of dietary exposure to mercury from the consumption of beluga whales for the historic (pre-Euroamerican contact) and modern Mackenzie Delta Inuit populations. For the historic populations, beluga intake was estimated from reconstructions of the pre-Euroamerican traditional diet, using archaeological and ethnographic data, while mercury levels in consumed flesh were estimated from beluga teeth recovered fro

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44

Kokelj, S. V., and C. R. Burn. "Geochemistry of the active layer and near-surface permafrost, Mackenzie delta region, Northwest Territories, Canada." Canadian Journal of Earth Sciences 42, no. 1 (2005): 37–48. http://dx.doi.org/10.1139/e04-089.

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The soluble ion content of the active layer and near-surface permafrost was determined at 41 sites in the Mackenzie delta region, Northwest Territories, Canada. In delta soils, Ca2+ and Mg2+ are the dominant soluble cations, but the quantity and relative abundance of Na+ increase with proximity to the Beaufort Sea coast. Soils beneath frequently flooded surfaces are ion rich in comparison with ground above the level of decadal flooding. Within a terrain type, near-surface permafrost soil solute concentrations are similar between paired cores spaced <1 m apart, but at greater distances (core

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Palmer, M. J., C. R. Burn, and S. V. Kokelj. "Factors influencing permafrost temperatures across tree line in the uplands east of the Mackenzie Delta, 2004–20101This article is one of a series of papers published in this CJES Special Issue on the theme of Fundamental and applied research on permafrost in Canada.2Polar Continental Shelf Contribution 03611." Canadian Journal of Earth Sciences 49, no. 8 (2012): 877–94. http://dx.doi.org/10.1139/e2012-002.

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Air and near-surface ground temperatures, late-winter snow conditions, and characteristics of the vegetation cover and soil were measured across the forest–tundra transition in the uplands east of the Mackenzie Delta, Northwest Territories, in 2004–2010. Mean late-winter snow depth decreased northward from 73 cm in the subarctic boreal forest near Inuvik to 22 cm in low-shrub tundra. Annual near-surface ground temperatures decreased northward by 0.1–0.3 °C/km near the northern limit of trees, in association with an abrupt change in snow depth. The rate decreased to 0.01–0.06 °C/km in the tundr

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Lizotte, Martine, Bennet Juhls, Atsushi Matsuoka, et al. "Nunataryuk field campaigns: understanding the origin and fate of terrestrial organic matter in the coastal waters of the Mackenzie Delta region." Earth System Science Data 15, no. 4 (2023): 1617–53. http://dx.doi.org/10.5194/essd-15-1617-2023.

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Abstract. Climate warming and related drivers of soil thermal change in the Arctic are expected to modify the distribution and dynamics of carbon contained in perennially frozen grounds. Thawing of permafrost in the Mackenzie River watershed of northwestern Canada, coupled with increases in river discharge and coastal erosion, triggers the release of terrestrial organic matter (OMt) from the largest Arctic drainage basin in North America into the Arctic Ocean. While this process is ongoing and its rate is accelerating, the fate of the newly mobilized organic matter as it transits from the wate

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Lizotte, Martine, Bennet Juhls, Atsushi Matsuoka, et al. "Nunataryuk field campaigns: understanding the origin and fate of terrestrial organic matter in the coastal waters of the Mackenzie Delta region." Earth System Science Data 15 (April 13, 2023): 1617–53. https://doi.org/10.5194/essd-15-1617-2023.

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Climate warming and related drivers of soil thermal change in the Arctic are expected to modify the distribution and dynamics of carbon contained in perennially frozen grounds. Thawing of permafrost in the Mackenzie River watershed of northwestern Canada, coupled with increases in river discharge and coastal erosion, triggers the release of terrestrial organic matter (OMt) from the largest Arctic drainage basin in North America into the Arctic Ocean. While this process is ongoing and its rate is accelerating, the fate of the newly mobilized organic matter as it transits from the watershed thro

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Klingebiel, M., A. de Lozar, S. Molleker, et al. "Arctic low-level boundary layer clouds: in situ measurements and simulations of mono- and bimodal supercooled droplet size distributions at the top layer of liquid phase clouds." Atmospheric Chemistry and Physics 15, no. 2 (2015): 617–31. http://dx.doi.org/10.5194/acp-15-617-2015.

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Abstract. Aircraft borne optical in situ size distribution measurements were performed within Arctic boundary layer clouds with a special emphasis on the cloud top layer during the VERtical Distribution of Ice in Arctic clouds (VERDI) campaign in April and May 2012. An instrumented Basler BT-67 research aircraft operated out of Inuvik over the Mackenzie River delta and the Beaufort Sea in the Northwest Territories of Canada. Besides the cloud particle and hydrometeor size spectrometers the aircraft was equipped with instrumentation for aerosol, radiation and other parameters. Inside the cloud,

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Wilcox, Evan J., Brent B. Wolfe, and Philip Marsh. "Hydrological, meteorological, and watershed controls on the water balance of thermokarst lakes between Inuvik and Tuktoyaktuk, Northwest Territories, Canada." Hydrology and Earth System Sciences 27, no. 11 (2023): 2173–88. http://dx.doi.org/10.5194/hess-27-2173-2023.

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Abstract. Thermokarst lake water balances are becoming increasingly vulnerable to change in the Arctic as air temperature increases and precipitation patterns shift. In the tundra uplands east of the Mackenzie Delta in the Northwest Territories, Canada, previous research has found that lakes responded non-uniformly to year-to-year changes in precipitation, suggesting that lake and watershed properties mediate the response of lakes to climate change. To investigate how lake and watershed properties and meteorological conditions influence the water balance of thermokarst lakes in this region, we

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Klingebiel, M., A. de Lozar, S. Molleker, et al. "Arctic low-level boundary layer clouds: in-situ measurements and simulations of mono- and bimodal supercooled droplet size distributions at the cloud top layer." Atmospheric Chemistry and Physics Discussions 14, no. 10 (2014): 14599–635. http://dx.doi.org/10.5194/acpd-14-14599-2014.

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Abstract. Aircraft borne optical in-situ size distribution measurements were performed within Arctic boundary layer clouds, with a special emphasis on the cloud top layer, during the VERtical Distribution of Ice in Arctic Clouds (VERDI) campaign. The observations were carried out within a joint research activity of seven German institutes to investigate Arctic boundary layer-, mixed-phase clouds in April and May 2012. An instrumented Basler BT-67 research aircraft operated out of Inuvik over the Mackenzie River delta and the Beaufort Sea in the Northwest Territories of Canada. Besides the clou

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