Relevant bibliographies by topics / Delta-like 4

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers
  5. Reports

Academic literature on the topic 'Delta-like 4'

Author: Grafiati
Published: 4 June 2021
Last updated: 16 February 2022

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Journal articles on the topic "Delta-like 4"

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Andrawes, Marie Blanke, Xiang Xu, Hong Liu, et al. "Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1." Journal of Biological Chemistry 288, no. 35 (2013): 25477–89. http://dx.doi.org/10.1074/jbc.m113.454850.

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Fung, Erik, Sai-Man Timothy Tang, James P. Canner, et al. "Delta-Like 4 Induces Notch Signaling in Macrophages." Circulation 115, no. 23 (2007): 2948–56. http://dx.doi.org/10.1161/circulationaha.106.675462.

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Nakano, Toshiaki, Daiju Fukuda, Jun-ichiro Koga, and Masanori Aikawa. "Delta-Like Ligand 4-Notch Signaling in Macrophage Activation." Arteriosclerosis, Thrombosis, and Vascular Biology 36, no. 10 (2016): 2038–47. http://dx.doi.org/10.1161/atvbaha.116.306926.

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Claxton, Suzanne, and Marcus Fruttiger. "Periodic Delta-like 4 expression in developing retinal arteries." Gene Expression Patterns 5, no. 1 (2004): 123–27. http://dx.doi.org/10.1016/j.modgep.2004.05.004.

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Luca, V. C., K. M. Jude, N. W. Pierce, M. V. Nachury, S. Fischer, and K. C. Garcia. "Structural basis for Notch1 engagement of Delta-like 4." Science 347, no. 6224 (2015): 847–53. http://dx.doi.org/10.1126/science.1261093.

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Yan, M., and G. D. Plowman. "Delta-like 4/Notch Signaling and Its Therapeutic Implications." Clinical Cancer Research 13, no. 24 (2007): 7243–46. http://dx.doi.org/10.1158/1078-0432.ccr-07-1393.

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Yu, Yi, Yang Zhao, Guangming Zhou, and Xiang Wang. "Therapeutic Efficacy of Delta-Like Ligand 4 Gene Vaccine Overexpression on Liver Cancer in Mice." Technology in Cancer Research & Treatment 19 (January 1, 2020): 153303382094220. http://dx.doi.org/10.1177/1533033820942205.

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Delta-like ligand 4 is a notch ligand that is predominantly expressed in the endothelial tip cells and plays essential roles in the regulation of angiogenesis. In this study, we explored the therapeutic effects of delta-like ligand 4 gene vaccine overexpression on the syngeneic model mouse model of liver cancer and the underlying mechanisms. Mouse hepatocellular carcinoma cell line H22-H8D8 was used to generate subcutaneous syngeneic model liver cancer in Kunming mice, and the effects of recombinant plasmid pVAX1 containing delta-like ligand 4 vaccine on tumor growth was examined. Compared to
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Liu, Ya-Rong, Ying-Yun Guan, Xin Luan, et al. "Delta-like ligand 4-targeted nanomedicine for antiangiogenic cancer therapy." Biomaterials 42 (February 2015): 161–71. http://dx.doi.org/10.1016/j.biomaterials.2014.11.039.

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Liu, Stanley K., Saif A. S. Bham, Emmanouil Fokas, et al. "Delta-Like Ligand 4–Notch Blockade and Tumor Radiation Response." JNCI: Journal of the National Cancer Institute 103, no. 23 (2011): 1778–98. http://dx.doi.org/10.1093/jnci/djr419.

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Mazella, J., S. Liang, and L. Tseng. "Expression of Delta-Like Protein 4 in the Human Endometrium." Endocrinology 149, no. 1 (2007): 15–19. http://dx.doi.org/10.1210/en.2007-0477.

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Activation of Delta-Notch signaling pathway promotes the development of the vascular system in embryo, normal adult tissues, and cancerous lesions. Delta and Notch genes are known to be expressed in endothelial cells, and little is known of their expression beyond the vascular system. The purpose of this study was to investigate whether Delta gene would be expressed in cells of the uterine endometrium. In this study, we found that the human endometrial cells expressed one of the Delta ligands, Delta-like 4 protein (Dll4). Dll4 was expressed in human endometrium in a spatiotemporal fashion. Imm
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Dissertations / Theses on the topic "Delta-like 4"

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Shi, Wen. "Delta-like 4 - Notch signalling in angiogenesis and tumour biology." Thesis, University of Oxford, 2007. http://ora.ox.ac.uk/objects/uuid:ab00e82c-844c-460c-a6d8-a1a521e47144.

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Notch signalling plays a key role in physiological development and tumourigenesis. The recent discovery and characterisation of Notch ligand Delta-like 4 (D114), which is predominantly expressed in endothelial cells, have underscored the role of Notch signalling in angiogenesis. This thesis investigates the regulation and function of D114-Notch signalling in angiogenesis and tumourigenesis. First, the D114-Notch pathway interacted with the cellular hypoxia-sensing pathway. In human umbilical vein endothelial cells (HUVECs), D114 overexpression repressed hypoxic induction, and the repression wa
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Patel, Nilay Nimit Sunil. "The role of the Delta-like 4 ligand in tumour angiogenesis." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613862.

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Boardman, Rachel. "Vascular permeability, angiogenesis and the role of delta-like ligand 4." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47687/.

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Cardiovascular disease, of which ischaemic diseases such as stroke and peripheral arterial disease make up a large proportion, are the leading cause of death worldwide. The endogenous response to ischaemia is to upregulate growth factors to stimulate the growth of new vessels and in some cases, form a collateral network. The concept of therapeutic stimulation has therefore become a priority area of cardiovascular research. The collateral network formed must consist of intact, stable, non-leaky vessels that can respond appropriately to stimuli. While the potent angiogenic driver, vascular endot
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Bham, Saif Ahmed Shahab. "Role of delta-like 4 in solid tumours and response to radiation therapy." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:f977581c-a460-4876-9ce4-dcbe9494aa1e.

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Delta-like ligand 4 (DLL4) is a ligand for the Notch family of receptors. DLL4 is an important regulator of angiogenesis and DLL4 blockade promotes non-productive angiogenesis and delays tumour growth. The aim of this thesis was to investigate the effects of anti-DLL4 therapy in solid tumours in combination with a clinically relevant dose of ionising radiation (5 Gy; IR) and to analyse alterations in the Notch pathway induced by the treatments. Combining both treatments resulted in a greater than additive tumour growth delay in LS174T tumours, compared to either treatment alone. DLL4 blockade
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Schneider, Janina Anne. "Elucidating the input of notch ligand delta-like 4 (dll4) in zebrafish blood stem cell ontogeny." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:b6798f11-1970-48a9-96fe-1bbb3cb36766.

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Multipotent haematopoietic stem cells (HSCs) supply the organism with mature blood cells of all lineages throughout adult life. These cells first originate in the dorsal aorta (DA) of the vertebrate embryo, and a multitude of signalling pathways regulate their specification in the embryo. The emergence of HSCs is dependent on appropriate arterial specification and vessel maturation, processes which are heavily dependent on Notch signalling. This arterial involvement of Notch obscures its later roles in HSC specification. The Notch ligand dll4 is crucially involved in arterial development in th
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Williams, Cassin Kimmel. "The Notch ligand delta-like 4 as a modulator of endothelial cell function and tumour-induced angiogenesis." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510407.

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Badenes, Marina Martins. "In vivo evaluation of the role of Delta-like 4/Notch signaling in the development of intestinal tumors." Doctoral thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2016. http://hdl.handle.net/10400.5/11190.

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Tese de Doutoramento em Ciências Veterinárias, especialidade de Ciências Biológicas e Biomédicas<br>Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related death in the Western world. Dll4/Notch signaling has been shown to regulate tumor angiogenesis and cancer stem cell maintenance in CRC, but how it affects the intestinal precancerous lesions that lead to CRC initiation is not known. Therefore we evaluated the role of Dll4/Notch pathway during intestinal tumorigenesis. For that we used two well-established mouse models of CRC, the ApcMi
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Sukonina, Valentina. "Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1343.

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Djokovic, Dusan. "The role of the Delta-like 4 Notch ligand in tumor angiogenesis." Doctoral thesis, 2011. http://hdl.handle.net/10451/6646.

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Tese de doutoramento, Ciências Biomédicas (Ciências Biopatológicas), Universidade de Lisboa, Faculdade de Medicina, 2012<br>Clinically significant tumors induce their own vascularization using molecular mechanisms involved in the regulation of physiological angiogenesis. One of these mechanisms is mediated by Delta-like 4 (Dll4)/Notch signaling, which is known to play a fundamental role in the regulation of embryonic angiogenesis and arterial specification. Up-regulated in animal and human tumors, Dll4 represents the focus of the work presented in this thesis, which aimed to characterize its f
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El, Kaffas Ahmed. "An Investigation of Vascular Strategies to Augment Radiation Therapy." Thesis, 2014. http://hdl.handle.net/1807/65658.

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Radiation therapy is administered to more than 50% of patients diagnosed with cancer. Mechanisms of interaction between radiation and tumour cells are relatively well understood on a molecular level, but much remains uncertain regarding how radiation interacts with the tumour as a whole. Recent studies have suggested that tumour response to radiation may in fact be regulated by endothelial cell response, consequently stressing the role of tumour blood vessels in radiation treatment response. As a result, various treatment regimens have been proposed to strategically combine radiation with vasc
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Book chapters on the topic "Delta-like 4"

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Thurston, Gavin, Irene Noguera-Troise, Ivan B. Lobov, et al. "Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis." In Angiogenesis. Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-71518-6_19.

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Conference papers on the topic "Delta-like 4"

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Luca, Vincent C., Kevin M. Jude, Nathan W. Pierce, Maxence V. Nachury, Suzanne Fischer, and K. Christopher Garcia. "Abstract B068: Structural basis for Notch1 engagement of Delta-like 4 and Jagged1." In Abstracts: CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr15-b068.

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Sampath, V., H. Menden, N. Townley, et al. "Delta Like 4 (DLL4), an Endothelial Specific Notch Ligand Is Critical for Lung Vascular Arborization and Alveolarization." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7413.

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Fischer, Marcus, Wan-Ching Yen, John Lewicki, Austin Gurney, and Timothy Hoey. "Abstract 4295: The combination of a novel anti-delta-like 4 ligand (DLL4) antibody with irinotecan inhibits growth of Kras-mutated colorectal tumors." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4295.

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Mattson, Bethany, Jodi Moriguchi, H. Toni Jun, et al. "Abstract 2991: Triple combination of bevacizumab, anti-DLL4 (delta like ligand 4) and trebananib gives enhanced therapeutic effects in three xenograft tumor models." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2991.

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Yen, W., M. Fischer, J. Lewicki, A. Gurney, and T. Hoey. "Targeting Cancer Stem Cells and Vasculature by a Novel Anti-Delta-Like 4 Ligand (DLL4) Antibody for Treatment of Triple Negative Breast Cancer." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-5071.

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Srivastava, Minu, Christopher L. Murriel, Julie Roda, et al. "Abstract 255: Dual targeting of Delta-like ligand 4 (DLL4) and programmed death 1(PD1) inhibits tumor growth and generates enhanced long-term immunological memory." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-255.

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Yen, Wan-Ching, Marcus Fischer, John Lewicki, Austin Gurney, and Timothy Hoey. "Abstract 15: Targeting cancer stem cells and vasculature by a novel anti-delta-like 4 ligand (DLL4) antibody inhibits triple-negative breast cancer tumor growth and delays tumor recurrence." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-15.

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Yen, W.-C., M. Fischer, L. Beviglia, et al. "Abstract P6-15-10: Targeting Delta-Like 4 Ligand (DLL4)/Notch Signaling by a Novel Anti-DLL4 Antibody Inhibits Tumor Growth through Altering Cancer Stem Cell and Epithelial-to-Mesenchymal Transition-Associated Genes in Triple Negative Breast Cancer." In Abstracts: Thirty-Third Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 8‐12, 2010; San Antonio, TX. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/0008-5472.sabcs10-p6-15-10.

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Reports on the topic "Delta-like 4"

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Chen, J., J. F. Zasadzinski, K. E. Gray, et al. BCS-like gap structure of HgBa{sub 2}CuO{sub 4+{delta}} tunnel junctions. Office of Scientific and Technical Information (OSTI), 1994. http://dx.doi.org/10.2172/10104581.

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