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Dissertations / Theses on the topic 'Dementia, vascular'

Author: Grafiati

Published: 4 June 2021

Last updated: 21 February 2023

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1

Cornett, Patricia F. "Risk Factors for Vascular Dementia." Thesis, University of North Texas, 2005. https://digital.library.unt.edu/ark:/67531/metadc4781/.

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Dementia is a devastating disorder that commonly affects people over the age of 65. Alzheimer's disease and vascular dementia are the most common forms of dementias. A number of studies have implicated cardiovascular risks as important factors in the development of dementia. These risks include high-risk behaviors such as smoking and risks related at least partially to health behaviors such as diet and exercise. This study examines a group of cardiovascular risk factors, as defined by the Framingham study, to ascertain if they are predictors of dementia. A retrospective chart review of 481cons

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2

Hill, Jonathan. "Development of a Differential Neurocognitive Profile for Alzheimer’s Dementia and Vascular Dementia." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc500158/.

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Alzheimer’s Dementia (AD) is among the most common diseases in the Geriatric population, and its prevalence is expected to quadruple by 2047.Vascular Dementia (VaD) is the second most frequent cause of dementia, with studies indicating VaD accounts for 10-20% of dementia cases across the globe. A diagnostic model differentiating AD and VaD would be clinically and scientifically valuable, considering the treatment approaches for these conditions are different. Although there are differences between AD and VaD on their neuropsychological profiles, a diagnostic model that successfully differentia

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3

Hecht, Moritz [Verfasser]. "The impact of vascular lesions in dementia / Moritz Hecht." Ulm : Universität Ulm, 2019. http://d-nb.info/1182430473/34.

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4

Purroy, Rodríguez Marina. "Canvis vasculars associats a l'envelliment en models animals de demència vascular." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673556.

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INTRODUCCIÓ: El deteriorament cognitiu d’origen vascular, i més concretament la demència vascular (DV), s’associa al compromís persistent del flux sanguini cerebral i representa la segona causa més freqüent de demència al món, després de la malaltia d’Alzheimer. La DV és una malaltia caracteritzada per múltiples i discretes lesions isquèmiques, lesions difuses a la substància blanca (leucoaraiosi) i hemorràgies cerebrals, entre d’altres. S’han dedicat gran quantitat d’esforços en la recerca dels mecanismes fisiopatològics subjacents a aquesta patologia però encara no es coneixen amb precisió.

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5

Laukka, Erika Jonsson. "Cognitive functioning during the transition from normal aging to dementia /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-934-3/.

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6

Everitt, Alaina. "Differential Scoring Patterns on the Clock Drawing Test: a Comparison of Vascular Dementia and Alzheimer's Dementia." Thesis, University of North Texas, 2006. https://digital.library.unt.edu/ark:/67531/metadc5283/.

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This study examined differences in scoring patterns among those diagnosed with Alzheimer's dementia and vascular dementia on the clock-drawing test. Archival clock drawing data was retrieved on 279 patients presenting at a county hospital-based memory clinic. Analysis of drawings was based on frequency of qualitative errors, as well as an overall quantitative score. Mean comparisons found those patients with Alzheimer's dementia to perform worse on both quantitative and qualitative scoring measures. However, Pearson's chi-squared test revealed a significantly higher rate of spacing errors am

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7

Smith, Ronna M. "Cognitive and behavioral differences between Alzheimer's disease and vascular dementia /." View abstract, 2001. http://wilson.ccsu.edu/theses/etd-2002-??/ThesisTitlePage.html.

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Thesis (M.A.)--Central Connecticut State University, 2001.<br>Thesis advisor: C. Charles Mate-Kole. " ... in partial fulfillment of the requirements for the degree of Master of Arts in Psychology." Includes bibliographical references (leaves 36-44). Also available via the World Wide Web.

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8

Rönnemaa, Elina. "Predictors of Dementia : Insulin, Fatty Acids and Vascular Risk Factors." Doctoral thesis, Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-164528.

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Identification of modifiable risk factors for Alzheimer’s disease (AD) is crucial in order to diminish suffering from this devastating disease. The aim of this thesis was to investigate if different aspects of glucose metabolism, insulin, fatty-acid composition or other vascular risk factors predict the future development of AD and dementia. This thesis is based on the Uppsala Longitudinal Study of Adult Men (ULSAM) cohort, which started in 1970. A total of 2322 men at age 50 were examined with focus on vascular risk factors. The cohort was re-examined at ages 60, 71, 77, 82 and 88. Incident d

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9

Sakamoto, Maiko Spiers Mary. "Comparing Alzheimer's Disease and vascular dementia profiles on neuropsychological tests among Japanese elders /." Philadelphia, Pa. : Drexel University, 2009. http://hdl.handle.net/1860/3021.

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10

Jones, Sari. "Cognitive functioning in the preclinical stages of Alzheimer's disease and vascular dementia /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-366-3/.

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11

Hagnelius, Nils-Olof. "Vascular mechanisms in dementia with special reference to folate and fibrinolysis." Doctoral thesis, Örebro universitet, Hälsoakademin, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7785.

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The aim of this thesis was to study the biomarker homocysteine and other novel potential vascular risk factors for dementia. In an out-patient based study of a cohort of 926 consecutive subjects referred to our Memory Unit during 1996―2000, serum-folate was lower and total plasma homocysteine (tHcy) and serum methyl malonate were higher in subjects being prescribed with B12. In the subgroup diagnosed with dementia and with a positive family history of dementia, tHcy was higher than in the subgroup diagnosed as non-demented. It is necessary to supplement subjects with vitamin B12 deficiency wit

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12

Nishio, Keiko. "A mouse model characterizing features of vascular dementia with hippocampal atrophy." Kyoto University, 2011. http://hdl.handle.net/2433/142090.

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13

Silva, Magnolia Moreira da. "Associação entre fatores de risco cardiovasculares e demência vascular definitiva." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/7/7139/tde-05112018-151715/.

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Introdução: Estudos prévios analisaram a associação entre fatores de risco cardiovascular (FRCV) associados ao diagnóstico de demência vascular (DV) provável ou possível. No entanto, não foram encontrados estudos que analisassem a associação entre FRCV e a ocorrência de DV definitiva. Dessa maneira, ainda permanece obscura a associação entre os FRCV e a ocorrência de DV definitiva, ou seja, aquela diagnosticada por meio do exame neuropatológico, no qual se apresenta como padrão ouro. Objetivo: Avaliar a associação entre os FRCV e a ocorrência de DV definitiva, pura e mista. Método: Por meio de

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14

Kitamura, Akihiro. "Selective white matter abnormalities in a novel rat model of vascular dementia." Kyoto University, 2012. http://hdl.handle.net/2433/157460.

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15

Fahlander, Kjell. "Cognitive functioning in aging and dementia : the role of psychiatric and somatic factors /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-246-9.

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16

Liu, Junguang. "Development of an evidence-based Chinese herbal medicine for the management of vascular dementia." Thesis, View thesis, 2008. http://handle.uws.edu.au:8081/1959.7/33046.

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Vascular dementia (VaD), the second most common cause of dementia, causes substantial distress to patients and represents a significant burden to their families and communities. Currently, there is no effective treatment to reverse the brain damage associated with VaD. In general the drugs available for the management of cognitive problems in VaD are expensive and outcomes are uncertain. It is, therefore, important to seek out alternative approaches, which may prove effective, cheaper and safer. Chinese herbal medicine (CHM) has been used for the treatment of dementia-like disorders for centur

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17

Liu, Junguang. "Development of an evidence-based Chinese herbal medicine for the management of vascular dementia." View thesis, 2008. http://handle.uws.edu.au:8081/1959.7/33046.

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Thesis (Ph.D.)--University of Western Sydney, 2008.<br>A thesis presented to the University of Western Sydney, College of Health and Science, Centre for Complementary Medicine, in fulfilment of the requirements for the degree of Doctor of Philosophy. Includes bibliographies.

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18

Yamamoto, Yumi. "Characterization of the neurovascular pathology in CADASIL : a model for subcortical vascular dementia." Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1282.

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Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of the most common forms of hereditary vascular dementia (VaD). Characterised by early-onset strokes and cognitive impairment in the absence of vascular risk factors, CADASIL is an ideal model to understand the pathophysiology of VaD. Pathogenic mutations in the NOTCH3 gene, which encodes a single-pass transmembrane cell surface receptor expressed predominantly in vascular smooth muscle cells (VSMC), cause severe vascular alterations including VSMC degeneration, hyalinosis, deposition of

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19

Ashby, Emma Louise. "Involvement of the kallikrein-kinin system in Alzheimers disease and vascular dementia." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535229.

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20

Pantel, Johannes, Johannes Schröder, Marco Essig, Marek Jauss, G. Schneider, Katrin Eysenbach, Rüdiger von Kummer, Klaus Baudendistel, Lothar R. Schad, and Michael V. Knopp. "In vivo Quantification of Brain Volumes in Subcortical Vascular Dementia and Alzheimer’s Disease." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135848.

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Quantitative magnetic resonance imaging (MRI) was used to assess global and regional cerebral volumes in patients with a clinical diagnosis of subcortical vascular dementia (VD) and Alzheimer’s disease (AD). Whole brain volume, cerebrospinal fluid volume, volumes of the temporal, frontal and parietal lobes, the cerebellum and the amygdala-hippocampus complex were determined using a personal computer-based software. Seventeen patients with VD, 22 patients with AD and 13 healthy controls were included. Analysis of covariance using age as covariate demonstrated significant mean differences betwee

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21

Pantel, Johannes, Johannes Schröder, Marco Essig, Marek Jauss, G. Schneider, Katrin Eysenbach, Rüdiger von Kummer, Klaus Baudendistel, Lothar R. Schad, and Michael V. Knopp. "In vivo Quantification of Brain Volumes in Subcortical Vascular Dementia and Alzheimer’s Disease." Karger, 1998. https://tud.qucosa.de/id/qucosa%3A27682.

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Quantitative magnetic resonance imaging (MRI) was used to assess global and regional cerebral volumes in patients with a clinical diagnosis of subcortical vascular dementia (VD) and Alzheimer’s disease (AD). Whole brain volume, cerebrospinal fluid volume, volumes of the temporal, frontal and parietal lobes, the cerebellum and the amygdala-hippocampus complex were determined using a personal computer-based software. Seventeen patients with VD, 22 patients with AD and 13 healthy controls were included. Analysis of covariance using age as covariate demonstrated significant mean differences betwee

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22

Poljak, Anne Medical Sciences Faculty of Medicine UNSW. "Oxidative, inflammatory and vascular factors in Alzheimer's disease." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/41273.

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In spite of impressive recent progress, the aetiopathogenesis of Alzheimers disease (AD) remains incompletely understood. The distinctive neuropathological features of AD, in particular the plaques and tangles, have been the particular focus of most aetiological theories. It is well accepted that AD is a multifactorial disease, with alterations to a variety of brain structures and cell types, including neurons, glia and the brain vasculature. Studies of risk factors have revealed a diversity of genetic variables that interact with health, diet and lifestyle-related factors in the causation o

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23

Amar, Khaled. "White matter low attenuation in patients with cognitive impairment : a memory clinic population." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324234.

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24

Hung, Ka-lok Victor. "The role of astrocytic endothelin-1 in dementia associated with Alzheimer's disease and mild ischemic stroke." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B42181987.

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25

Harris, Rebekah Lynn Guarnaccia Charles Anthony. "Neurocognitive implications of diabetes on dementia as measured by an extensive neuropsychological battery." [Denton, Tex.] : University of North Texas, 2008. http://digital.library.unt.edu/permalink/meta-dc-9774.

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26

Voss, Sarah. "Cognitive deficits in dementia : evaluation and application of a neuropsychological test battery in the differential diagnosis of Alzheimer's disease and vascular dementia." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289560.

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27

Dynan, Kevin B. "A study of recently proposed cardiovascular risk factors in Alzheimer's disease and vascular dementia." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322645.

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28

Hampstead, Benjamin M. Chute Douglas L. "Dissociation of vascular dementia and Alzheimer's disease using a sequential working memory and recognition task /." Philadelphia, Pa. : Drexel University, 2006. http://dspace.library.drexel.edu/handle/1860%20/876.

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29

Cornett, Patricia F. Hall James. "Factors of the geriatric depression scale that may distinguish between four cognitive diagnostic groups normal, mild cognitive impairment, dementia of the Alzheimer's type, and vascular dementia /." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/ark:/67531/metadc12105.

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30

McCullagh, C. D. "An investigation of inflammatory and vascular genetic risk factors for stroke and dementia following stroke." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403191.

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31

Helman, Alex Marian. "VASCULAR COGNITIVE IMPAIRMENT AND DEMENTIA: THE IMPORTANCE OF MIXED PATHOLOGIES FROM MOUSE MODELS TO HUMANS." UKnowledge, 2018. https://uknowledge.uky.edu/biochem_etds/38.

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Age-related neurologic disease is a significant and growing burden on our society. Although the largest share of research effort has typically been devoted to the common neurodegenerative illnesses (such as Alzheimer’s disease, or AD), the reality is that nearly all cases of neurodegenerative disease possess elements of mixed pathology. Vascular contributions to cognitive impairment and dementia (VCID) is a complex form of dementia, combining aspects of vascular disease and other forms of dementia, such as Alzheimer’s disease. This pathology is heterogeneous and can include cerebral amyloid an

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32

Ávila, Funes José Alberto. "Fragilité et cognition chez le sujet âgé : approche épidémiologique." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR21964/document.

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La « fragilité » fait référence à un état de forte vulnérabilité qui résulte d’une réduction des réserves adaptatives de multiples systèmes biologiques et physiologiques sous l’action conjuguée de l’âge, de maladies et du contexte de la vie. Ce syndrome accroit la vulnérabilité de l’individu ainsi que son risque de dépendance, de chutes, d’hospitalisations, d’entrée en institution et de mortalité. La définition la plus utilisée, celle de Fried et collaborateurs, est basée sur la prise en compte d’éléments exclusivement physiques mais la possibilité d’inclure à cette définition d’autres composa

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33

DenBesten, Nicholas Paul. "The Influence of Education and Age on Neurocognitive Test Performance in Alzheimer's Disease and Vascular Dementia." Thesis, NSUWorks, 2009. https://nsuworks.nova.edu/cps_stuetd/25.

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This research involves an examination of the relationship between education and age on a wide array of neuropsychological test measures among patients diagnosed with Alzheimer's and vascular dementia. The purpose of this study was to investigate the role of education as an attenuating factor to neurocognitive decline in dementia. Although numerous studies have been published regarding the relationship between educational attainment and AD, few have included other subtypes of dementia in their investigation. To further expand the generalizability of previous findings, the sample in this study i

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34

Israelsson, Larsen Hanna. "Comorbidity and vascular risk factors associated with idiopathic normal pressure hydrocephalus : the INPH-CRasH Study." Doctoral thesis, Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120175.

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Idiopathic normal pressure hydrocephalus (INPH) is a dementia treatable by insertion of a cerebrospinal fluid shunt. It has been suggested that INPH has similar pathophysiological mechanisms as cerebrovascular disease, but the vascular risk factor (VRF) profile of INPH patients has not been assessed using a modern epidemiological approach. The cognitive symptoms of INPH resemble the symptoms of depression, but the prevalence of depression among INPH patients is unknown. In addition, few studies investigate the impact of shunting on the quality of life (QoL), and no study has investigated the i

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35

Cornett, Patricia F. "Factors of the Geriatric Depression Scale that may Distinguish between Four Cognitive Diagnostic Groups: Normal, Mild Cognitive Impairment, Dementia of the Alzheimer's Type, and Vascular Dementia." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc12105/.

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The purpose of the current study was to explore the relationship between cognitive status and depression in a sample of geriatric patients. Participants included 282 geriatric patients ranging in age from 65 to 96 years who were classified according to diagnosis as: DAT, VaD, MCI, and Norm. All were referred for neurocognitive testing from the Geriatric Assessment Program (GAP) at the University of North Texas Health Science Center (UNTHSC) in Fort Worth, Texas. This study sought to identify factor structures for two versions of the GDS using a geriatric sample of cognitively impaired and inta

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36

Hung, Ka-lok Victor, and 洪家樂. "The role of astrocytic endothelin-1 in dementia associated with Alzheimer's disease and mild ischemic stroke." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B42181987.

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37

Harris, Rebekah Lynn. "Neurocognitive implications of diabetes on dementia as measured by an extensive neuropsychological battery." Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc9774/.

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Diabetes is a disease with a deleterious pathology that currently impacts 4.5 million individuals within the United States. This study examined the ability of a specific neuropsychological battery to identify and classify dementia type, investigated the impact of diabetes on cognition and analyzed the ability of the memory measures of the 7 Minute Screen (7MS) and the Rey-Osterrieth Recall to correctly categorize dementia type when not used in combination with a full battery. The battery in addition to exhaustive patient history, medical chart review and pertinent tests were used in initial di

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38

Freitas, Maria Isabel d'Avila. "Habilidades linguísticas de pacientes com demência vascular: estudo comparativo com a doença de Alzheimer." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-27092010-140422/.

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INTRODUÇÃO: Os quadros demenciais comprometem gradualmente todos os domínios cognitivos e comportamentais. Deterioração progressiva nas funções de linguagem também é observada, e pode ser uma medida importante no diagnóstico precoce de demência. É escasso o conhecimento sobre o padrão de linguagem na Demência Vascular (DV). Os poucos estudos existentes têm analisado aspectos lingüísticos isolados e produzido resultados conflitantes. A Bateria Arizona para Desordens da Comunicação em Demência (ABCD) foi desenvolvida para identificar e avaliar alterações de comunicação funcional associadas à dem

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39

Al-Janabi, Omar M. "CEREBROVASCULAR RISK FACTORS, ARTERIOLAR SCLEROSIS, AND COGNITIVE DECLINE IN THE KENTUCKY APPALACHIAN “STROKE-BELT”." UKnowledge, 2016. http://uknowledge.uky.edu/medsci_etds/5.

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The relationship between cerebrovascular disease (CVD) risk factors and cognitive impairment or dementia has been widely studied with significant variability in findings between groups. We hypothesized that chronic small vessel injury in the form of arteriolar sclerosis, measured quantitatively using MRI to measure total white matter hyperintensity (WMH) volumes, would identify specific association of CVD risk factors and patterns of cognitive decline, associated with mild cognitive impairment of the cerebrovascular type, that represent the core features of vascular cognitive impairment in our

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40

Gueniot, Florian. "Contribution de la voie Wnt dans la stabilité de la barrière hémato-encéphalique." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0386.

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La démence est caractérisée par une détérioration progressive des capacités mentales qui compromettent l’autonomie des patients. Le vieillissement en est le facteur de risque majeur. La population mondiale vieillissante, l’absence de traitement, ainsi que l’augmentation des individus touchés estimé à 50 millions, permettent d’estimer un coût de santé publique triplé à 4 trillions de dollars d’ici à 2050. Les études récentes tendent à montrer un rôle crucial de la dysfonction vasculaire dans les pathologies de démence. En effet une large étude neuropathologique basée sur l’autopsie des patients

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41

Anastácio, Janine Beatriz Ramos. "Efeito neuroprotetor do resveratrol no modelo de demência por hipoperfusão encefálica crônica em ratos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/77994.

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A hipoperfusão cerebral crônica (HCC) é um importante fator de risco para o declínio cognitivo e outras disfunções cerebrais, tais como Doença de Alzheimer e Demência Vascular. O objetivo deste estudo foi investigar o efeito neuroprotetor do Resveratrol (RSV), avaliando parâmetros comportamentais, bioquímicos e morfológicos, em um modelo experimental de Demência Vascular. Ratos Wistar adultos foram submetidos ao modelo modificado da HCC através da oclusão permanente de 2 vasos (2VO) e tratamento diário, iniciado uma hora após oclusão permanente dos vasos, com injeções intraperitoneais (20 mg/k

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Schmid, Benedikt [Verfasser], and Wolfgang [Akademischer Betreuer] Müllges. "Relation between cerebral arterio-venous transit time and neuropsychological performance in patients with vascular dementia / Benedikt Schmid. Betreuer: Wolfgang Müllges." Würzburg : Universität Würzburg, 2013. http://d-nb.info/1102820040/34.

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43

Matioli, Maria Niures Pimentel dos Santos. ""Estudo comparativo do desempenho em testes neuropsicológicos de pacientes com diagnóstico de doença de Alzheimer e demência vascular"." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-01022006-212034/.

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A doença de Alzheimer (DA) e a demência vascular (DV), especialmente a sua forma subcortical, são responsáveis pela maioria dos quadros de demência em idosos, nem sempre facilmente diferenciadas do ponto de vista clínico. O objetivo do estudo foi comparar o desempenho de pacientes com DA e com DV em uma bateria breve de testes cognitivos (Mini-exame do estado mental e bateria Neuropsi para confirmar o diagnóstico de demência; CLOX 1 e 2, fluência verbal categoria animal e fonêmica, EXIT 25 e teste de memória tardia da bateria breve de rastreio cognitivo), e verificar seu valor no diagnóstico d

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44

Behensky, Adam Alexander. "Sigma Receptor Activation Mitigates Toxicity Evoked by the Convergence of Ischemia, Acidosis and Amyloid-beta." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5641.

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Stroke is the fifth leading cause of death in the United States and a major cause of long-term disability in industrialized countries. The core region of an ischemic stroke dies within minutes due to activation of necrotic pathways. Outside of this core region is the penumbral zone, where some perfusion is maintained via collateral arteries. Delayed cell death occurs in this area due to the triggering of apoptotic mechanisms, which expands the ischemic injury over time. The cellular and molecular events that produce the expansion of the ischemic core continue to be poorly understood. The incre

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45

Baptista, Miguel José de Carvalho Viana. "Alterações da substância branca cerebral relacionadas com o envelhecimento." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2009. http://hdl.handle.net/10362/5194.

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INTRODUÇÃO: Estudos prévios, com técnicas de imagem, documentam de forma consistente a existência de alterações da substância branca cerebral relacionadas com o envelhecimento (ASBRE). Tais alterações poderão ter um papel importante no declínio funcional do idoso, reflectindo‐se sobretudo no desempenho motor e cognitivo, com repercussão evidente na prática clínica. Apesar disso, a caracterização em definitivo dos fenótipos clínicos e da evolução das ASBRE continua por esclarecer, possivelmente pelas dificuldades metodológicas de que se reveste o seu estudo, incluindo: a adequação das ba

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46

Yasuda, Ken. "Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion." Kyoto University, 2020. http://hdl.handle.net/2433/253172.

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47

McDonald, Alexa. "Assessing the robustness of the Test of Premorbid Functioning (TOPF) as a measure of premorbid intelligence in Alzheimer's and vascular dementia, and clinical research portfolio." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6793/.

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Introduction: The Test of Premorbid Functioning (TOPF) is a relatively new reading test designed to estimate premorbid intelligence in people with a diagnosed or suspected dementia. A discrepancy between premorbid and current functioning is indicative of cognitive decline. Previous studies have reported mixed results on the validity of reading tests in people with dementia, and the TOPF has yet to be investigated as to how well it holds in dementia. Objectives: To assess the robustness of the TOPF against the Spot-the-Word (version 2; STW-2) and a demographic regression equation in estimating

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Barei, Moniri Lenoir Hermine. "Relations entre dépression, symptômes dépressifs et démences chez le sujet âgé : rôle de la pression artérielle." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T035/document.

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La dépression (caractérisée ou subsyndromique) est fréquente tout au long de la vie et les démences sont des pathologies fréquentes du sujet âgé. Une association longitudinale entre la dépression ou les symptômes dépressifs et la démence a été rapportée. Cependant, le sens de cette association demeure incertain et ses mécanismes pathogéniques selon l’âge de l’apparition des manifestations dépressives sont largement méconnus. Les facteurs de risque vasculaires sont associés à la démence et une comorbidité vasculaire est également retrouvée chez le sujet âgé dépressif. L’hypothèse qu’un ou des f

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Örulv, Linda. "Fragile identities, patched-up worlds : Dementia and meaning-making in social interaction." Doctoral thesis, Linköpings universitet, Hälsa och samhälle, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11736.

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Denna avhandling fokuserar på det meningsskapande och begripliggörande som fortgår vid tilltagande demenssjukdom, i det sociala samspelet, och de utmaningar för demens-omsorgen som detta innebär. Studien är aktörsorienterad och adresserar frågan om hur personer med åldersrelaterade progressiva demenssjukdomar i den vardagliga kommuni-kationen söker förstå sina situationer, omgivningen och sina liv – alltsammans inom ra-men för det dagliga samspelet på ett demensboende. Av särskilt intresse är hur dessa per-soner hanterar problem som har att göra med att handla tillsammans med andra i en gemens

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Matioli, Maria Niures Pimentel dos Santos. "Associação entre diabetes mellitus e demência: estudo neuropatológico." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-18112016-111336/.

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A literatura científica vem debatendo sobre a existência de uma associação entre diabetes mellitus (DM) e demência, doença de Alzheimer (DA) e demência vascular (DV). O DM é um conhecido fator de risco para a doença cerebrovascular (DCV) e DV, porém não há consenso até o momento do real papel do DM no desenvolvimento das alterações neuropatológicas da DA. Objetivos: verificar a associação entre DM e demência, DM e alterações neuropatológicas da DA e DV. Métodos: os dados foram coletados do Banco de Encéfalos Humanos do Grupo de Estudos em Envelhecimento Cerebral da FMUSP estudados de 2004 a 20

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