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Relevant bibliographies by topics / Demethylation reaction

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Academic literature on the topic 'Demethylation reaction'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Demethylation reaction"

1

Wang, Qing, Xinmin Wang, and Shuo Pan. "Effect of the Kerogen Molecular Structure on the Formation of Methane During Kerogen Pyrolysis." Australian Journal of Chemistry 72, no. 3 (2019): 174. http://dx.doi.org/10.1071/ch18428.

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In this study, density functional theory (DFT) at the GGA/RPBE level was employed to examine the effects of the kerogen microstructure on the formation mechanism of methane during the pyrolysis of kerogen. The calculations prove that the evolution of CH4 during kerogen pyrolysis corresponds to demethylation, and the process of forming methane involves the interaction of intramolecular hydrogen atom transfer and assistant hydrogen atom transfer. In all reaction paths, the energy barrier of path 5 is the smallest at 260.56kJmol−1. The energy barrier of path 6 is the largest at 554.36kJmol−1. The

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Thavaneswaran, Shanti, Kristy McCamley, and Peter J. Scammells. "N-Demethylation of Alkaloids." Natural Product Communications 1, no. 10 (2006): 1934578X0600101. http://dx.doi.org/10.1177/1934578x0600101008.

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The removal of an N-methyl group, or N-demethylation, is a useful chemical transformation in organic synthesis which has particular importance in the field of alkaloid chemistry. Historically, tertiary N-methyl alkaloids have been N-demethylated using the same methods as for N-dealkylating tertiary amines. Such methodologies have included the von Braun reaction, the use of chloroformate and azodicarboxylate reagents and the Polonovski reaction, amongst others. Photochemical and biochemical procedures have also been successfully employed. This review will examine these N-demethylation procedure

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Davydova, Nadezhda Y., David A. Hutner, Kari A. Gaither, Dilip Kumar Singh, Bhagwat Prasad, and Dmitri R. Davydov. "High-Throughput Assay of Cytochrome P450-Dependent Drug Demethylation Reactions and Its Use to Re-Evaluate the Pathways of Ketamine Metabolism." Biology 12, no. 8 (2023): 1055. http://dx.doi.org/10.3390/biology12081055.

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In a search for a reliable, inexpensive, and versatile technique for high-throughput kinetic assays of drug metabolism, we elected to rehire an old-school approach based on the determination of formaldehyde (FA) formed in cytochrome P450-dependent demethylation reactions. After evaluating several fluorometric techniques for FA detection, we chose the method based on the Hantzsch reaction with acetoacetanilide as the most sensitive, robust, and adaptable to high-throughput implementation. Here we provide a detailed protocol for using our new technique for automatized assays of cytochrome P450-d

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Fayyaz, Anam, Seddy Makwinja, Seppo Auriola, Hannu Raunio, and Risto Juvonen. "Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals." Planta Medica 84, no. 05 (2017): 320–28. http://dx.doi.org/10.1055/s-0043-119886.

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AbstractScoparone is a natural bioactive compound in Chinese herbal medicines. It has numerous pharmacological actions, including liver protective, hypolipidemic, antitumor, and anti-inflammatory effects. The primary metabolism route of scoparone is O-demethylation to scopoletin or isoscopoletin catalyzed by CYP enzymes. The aims of our study were to identify the human CYP enzymes catalyzing scoparone 7-O-demethylation to scopoletin and to compare this oxidation reaction in liver microsomes among different species. A high throughput fluorescent-based assay method was developed to determine the

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Reid, Ian D. "Demethylation of the lignin model dimer 1-(3′,4′-dimethoxyphenyl)-2-(o-methoxyphenoxy)-propane-1,3-diol by the white-rot fungus Phlebia tremellosa." Canadian Journal of Botany 70, no. 3 (1992): 453–60. http://dx.doi.org/10.1139/b92-060.

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Phlebia tremellosa dealkylates nonphenolic β-O-4-linked lignin model dimers; the phenolic products are oxidized by laccase. There is no evidence of α,β-cleavage as catalyzed by lignin peroxidase in some other white rot fungi. Methanol is the product of demethylation of 1-(3′,4′-dimethoxyphenyl)-2-(o-methoxyphenoxy)-propane-1,3-diol, and the demethylation reaction can be assayed by the release of radioactive CH3OH from the 4′-O14CH3 labelled compound. In older cultures, the methanol is metabolized to CO2. Demethylation is stimulated by oxygen and blocked by several common metabolic inhibitors.

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Makino, Kosho, Yumi Hasegawa, Takahide Inoue, et al. "Chemoselective Demethylation of Methoxypyridine." Synlett 30, no. 08 (2019): 951–54. http://dx.doi.org/10.1055/s-0037-1612427.

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A chemoselective demethylation method for various methoxypyridine derivatives has been developed. Treatment of 4-methoxypyridine with L-selectride in THF for 2 h at reflux temperature afforded 4-hydroxypyridine in good yield; no reaction to anisole occurred. The utility of our method was demonstrated by the efficient synthesis of the metabolic substances of the antiulcer agent omeprazole. Chemoselective demethylation at the site of 3,5-dimethyl-4-methoxypyridine in the presence of 4-methoxybenzimidazole was achieved.

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Turhanen, Petri A., Janne Weisell, and Jouko J. Vepsäläinen. "Preparation of mixed trialkyl alkylcarbonate derivatives of etidronic acid via an unusual route." Beilstein Journal of Organic Chemistry 8 (November 20, 2012): 2019–24. http://dx.doi.org/10.3762/bjoc.8.228.

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A method to prepare four (3a–d) trialkyl alkylcarbonate esters of etidronate from P,P'-dimethyl etidronate and alkyl chloroformate was developed by utilizing unexpected demethylation and decarboxylation reactions. The reaction with the sterically more hindered isobutyl chloroformate at a lower temperature (90 °C) produced the P,P'-diester (2) as a stable intermediate product. A possible reaction mechanism is discussed to explain these methyl substitutions. These unusual reactions also clarify why it is difficult to prepare alkylcarbonate prodrugs from bisphosphonates. The compounds prepared we

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Ramadas, Chavakula, Saladi J. S. Chakradhar, Rao Mutyala Narayana, Raju Maddala Vijaya, and Babu K. Raghu. "A green process for demethylation reaction in synthesis of raloxifene hydrochloride." Journal of Indian Chemical Society Vol. 96, Mar 2019 (2019): 391–93. https://doi.org/10.5281/zenodo.5651023.

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Research and Development, Aurobindo Pharma Limited, Survey No: 71 & 72, Indrakaran Village, Sangareddy Mandal, Medak Dist-502 329, Telangna, India <em>E-mail</em>: ramadas.chavakula@gmail.com Tyche Industries Limited, H. No. C-21/A, Film Nagar, Jubilee Hills, Hyderabad-500 093, India Department of Engineering Chemistry, Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India <em>Manuscript received online 11 November 2018, revised 01 February 2019, accepted 08 February 2019</em> A green process for demethylation reaction in synthesis of raloxifene hydrochloride by using aluminium c

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Liu, Qian, Guan-xin Huang, Min-jie Liu, and Fen-Er Chen. "A Concise Total Synthesis of (±)-Camptothecin." Synthesis 51, no. 18 (2019): 3506–10. http://dx.doi.org/10.1055/s-0037-1611870.

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A total synthesis of racemic camptothecin, characterized by a concise construction of the ring systems and easy functional group transformation, is described. A domino reaction consisting of a Heck reaction and an aza-intramolecular Michael addition to form the C ring serves as the first key step in the synthesis. The D ring was constructed by a simple Wittig–Horner reaction followed by removal of the protective groups. Hydroxymethylation, demethylation, and lactone formation reactions were performed in one-pot to construct the E ring under hydrobromic acid conditions. This work provides an ef

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Moreira, Rui, Elba Ochoa, José Pinilla, António Portugal, and Isabel Suelves. "Liquid-Phase Hydrodeoxygenation of Guaiacol over Mo2C Supported on Commercial CNF. Effects of Operating Conditions on Conversion and Product Selectivity." Catalysts 8, no. 4 (2018): 127. http://dx.doi.org/10.3390/catal8040127.

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In this work, a Mo2C catalyst that was supported on commercial carbon nanofibers (CNF) was synthetized and tested in the hydrodeoxygenation (HDO) of guaiacol. The effects of operating conditions (temperature and pressure) and reaction time (2 and 4 h) on the conversion of guaiacol and products selectivity were studied. The major reaction products were cresol and phenol, followed by xylenols and toluene. The use of more severe operating conditions during the HDO of guaiacol caused a diversification in the reaction pathways, and consequently in the selectivity to products. The formation of pheno

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Dissertations / Theses on the topic "Demethylation reaction"

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Sauret-Ignazi, Ginette. "Métabolisme du gai͏̈acol par un moraxella sp : étude d'un nouveau cytochrome P-450 bactérien." Grenoble 1, 1988. http://www.theses.fr/1988GRE10084.

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Saxton, H. M. "Lanostenone demethylation via an organopalladium complex and intramolecular Diels-Alder reactions of allenic esters." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377679.

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Book chapters on the topic "Demethylation reaction"

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Stecca, C., and M. Duverger van Bogaert. "N-Demethylation Reactions in Intact Erythrocytes and Erythrocyte Supernatant." In Archives of Toxicology. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74117-3_52.

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Rahier, Alain, Maryse Taton, and Sophie Pascal. "Plant Sterol Biosynthesis. Identification of the Component Reactions of Oxidative Sterol C4-Demethylation." In Plant Lipid Metabolism. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-015-8394-7_92.

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Zhang, Tao, Kelin Li, Yuk Hei Cheung, Mark W. Grinstaff, and Pinghua Liu. "Photo-reduction facilitated stachydrine oxidative N-demethylation reaction: A case study of Rieske non-heme iron oxygenase Stc2 from Sinorhizobium meliloti." In Methods in Enzymology. Elsevier, 2024. http://dx.doi.org/10.1016/bs.mie.2024.05.002.

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Berg, Dieter, and Manfred Plempel. "Fungal Enzyme Targets." In Pre-Equilibrium Nuclear Reactions. Oxford University PressOxford, 1992. http://dx.doi.org/10.1093/oso/9780198517344.003.0008.

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Abstract The therapeutic situation in the treatment of fungal diseases changed dramatically with the development of the sterol biosynthesis inhibitors (SBis). The imidazoles and 1,2,4,-triazoles that are already on the market are highly effective topical and vaginal antimycotics, and oral administration has become possible in the case of some of these compounds. The azoles, originating from the chemical classes of imidazoles, 1,2,4-triazoles, pyridines, or pyrimidines, interfere with the biosynthesis of fungal sterols by inhibiting the demethylation at Cl4. The Cl4-a-demethylase is a mono oxyg

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Taber, Douglass F. "The Magnus Synthesis of ( ± )-Codeine." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0088.

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Although there have been many synthetic approaches to morphine and its methyl ether codeine 3, the pentacyclic structure of these Papaver alkaloids continues to intrigue organic chemists. Philip Magnus of the University of Texas devised (J. Am. Chem. Soc . 2009, 131, 16045) an elegant route to 3 based on the conversion of 1 to 2 by way of an intramolecular Michael addition. The starting point for the synthesis was the commercial bromoaldehyde 4. Coupling with 5 delivered the substituted biphenyl 6, which was carried on to the mixed bromo acetal 8. On exposure to fluoride ion, 8 was desilylated

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Kirstein, D., M. Kühn, F. Schubert, P. Mohr, and F. Scheller. "Immobilized Glucose Dehydrogenase for Cofactor Regeneration in Heme-Catalyzed Demethylation and Hydroxylation Reactions." In Acta Biotechnologica Volume 6, Number 3. De Gruyter, 1986. http://dx.doi.org/10.1515/9783112533024-014.

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Conference papers on the topic "Demethylation reaction"

1

Karasulu, Bora, Ozlem Keskin, and Burak Erman. "Reaction path analysis for demethylation process of histone tail lysine residues." In 2010 5th International Symposium on Health Informatics and Bioinformatics. IEEE, 2010. http://dx.doi.org/10.1109/hibit.2010.5478882.

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Gallo, Rafael D. C., Diandra P. Alencar, Murilo Yonekawa, and Rozanna M. Muzzi. "Study of the ortho-methoxy substituent group effect in selective demethylation reactions of methoxybenzoic acids." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_201393094448.

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