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Relevant bibliographies by topics / Demineralized Bone Matrix

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Academic literature on the topic 'Demineralized Bone Matrix'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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Journal articles on the topic "Demineralized Bone Matrix"

1

Frenkel, Sally R., Ronald Moskovich, Jeffrey Spivak, Zhi-Hu Zhang, and Anne B. Prewett. "Demineralized Bone Matrix." Spine 18, no. 12 (1993): 1634–39. http://dx.doi.org/10.1097/00007632-199309000-00011.

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Dogan, E., and Z. Okumus. "Cuttlebone used as a bone xenograft in bone healing." Veterinární Medicína 59, No. 5 (2014): 254–60. http://dx.doi.org/10.17221/7519-vetmed.

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This study was conducted to examine the potential of cuttlebone xenograft in the healing of bone using radiography and histology for a period of 24 weeks. One hundred and five New Zealand male rabbits with radius defects in the metaphyseal region were divided into five groups treated with cuttlebone, demineralized bone matrix, bovine cancellous graft, and tricalcium phosphate. The control was no treatment. Clinical, radiological, biochemical and histological evaluations were made 1, 2, 3, 4, 6, 12, and 24 weeks after surgery. Physiological measurements (body temperature, heart rate, and respiratory rate) were not affected by the treatments. The radiological score was greatest in the demineralised bone matrix and tricalcium phosphate groups (score of 8), followed by the bovine cancellous graft (score of 6), cuttlebone (score of 6), and control groups (score of 5). The histological score was greatest in the tricalcium phosphate group (score of 55), followed by the cuttlebone (score of 50), bovine cancellous graft (score of 48), demineralized bone matrix (score of 44) and control groups (score of 42). Oxidative enzyme activities were not different across the treatments. The lack of reinfection and infection responses and faster bone union highlight the potential of cuttlebone xenograft in orthopaedic surgery.  

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Li, Qiannan, Wenjie Zhang, Guangdong Zhou, Yilin Cao, Wei Liu, and Zhi-Yong Zhang. "Demineralized bone matrix-based microcarrier scaffold favors vascularized large bone regeneration in vivo in a rat model." Journal of Biomaterials Applications 33, no. 2 (2018): 182–95. http://dx.doi.org/10.1177/0885328218784370.

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Insufficient neo-vascularization of in vivo implanted cell-seeded scaffold remains a major bottleneck for clinical translation of engineered bone formation. Demineralized bone matrix is an ideal bone scaffold for bone engineering due to its structural and biochemical components similar to those of native bone. We hypothesized that the microcarrier form of demineralized bone matrix favors ingrowth of vessels and bone regeneration upon in vivo implantation. In this study, a rat model of femoral vessel pedicle-based bone engineering was employed by filling the demineralized bone matrix scaffolds inside a silicone chamber that surrounded the vessel pedicles, and to compare the efficiency of vascularized bone regeneration between microcarrier demineralized bone matrix and block demineralized bone matrix. The results showed that bone marrow stem cells better adhered to microcarrier demineralized bone matrix and produced more extracellular matrices during in vitro culture. After in vivo implantation, microcarrier demineralized bone matrix seeded with bone marrow stem cells formed relatively more bone tissue than block demineralized bone matrix counterpart at three months upon histological examination. Furthermore, micro-computed tomography three-dimensional reconstruction showed that microcarrier demineralized bone matrix group regenerate significantly better and more bone tissues than block demineralized bone matrix both qualitatively and quantitatively (p < 0.05). Moreover, micro-computed tomography reconstructed angiographic images also demonstrated significantly enhanced tissue vascularization in microcarrier demineralized bone matrix group than in block demineralized bone matrix group both qualitatively and quantitatively (p < 0.05). Anti-CD31 immunohistochemical staining of (micro-) vessels and semi-quantitative analysis also evidenced enhanced vascularization of regenerated bone in microcarrier demineralized bone matrix group than in block demineralized bone matrix group (p < 0.05). In conclusion, the microcarrier form of demineralized bone matrix is an ideal bone regenerative scaffold due to its advantages of osteoinductivity and vascular induction, two essentials for in vivo bone regeneration.

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Kim, J. T., H. J. Kang, H. N. Kim, et al. "Ectopic Osteoinduction by Variously Demineralized Allogenic Cortical Bone Matrix." Key Engineering Materials 342-343 (July 2007): 105–8. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.105.

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To improve ostegenic healing efficiency by demineralized bone matrix, we evaluated the ectopic bone formation induced by variously demineralized allogenic cortical bone matrices at subcutaneous and muscular sites in rats. The rat tubular cortical bone matrices were demineralized in heated 0.6N HCl at 60 °C for 5 and 20 mins, respectively, using a controlledheat ultrasonic cleaner and implanted in rat dorsal subcutaneous pouches and thigh muscles for 1-3 weeks. The influence of the demineralized condition of bone matrix on cellular proliferation and osteogenic differentiation was also evaluated in vitro by MTT assay and ALP staining. The cortical matrices were completely demineralized within 20 mins by sonication and heating of diluted 0.6 N HCl. The sonicated bone matrices in heated acidic solution at 60 °C revealed no adverse immunogenic and inflammatory response in vivo regardless of demineralized condition. Cellular proliferation and osteoblastic differentiation was facilitated by more fully demineralized. Ectopic bone formation was induced only by demineralized bone matrices and were more favorable in fully demineralized matrices. The ectopic bone induction was more favorably in subcutaneous pouches than in muscular tissue. These findings suggest that a fully demineralized cortical bone matrix maximizes osteogenic repair by exposing more bioactive molecules which in turn induce chondro- and osteognic differentiation of mesenchymal cells around the implanted matrices, and that the sonication of diluted 0.6 N HCl heated at 60 ° C is a rapid and effective method for sterile demineralized graft preparation.

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Seo, Seog Jin, Seok Beom Song, Ji Hwa Chae, et al. "Hydroxyl Groups in Demineralized Bone Matrix." Key Engineering Materials 342-343 (July 2007): 381–84. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.381.

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Human demineralized bone matrix (DBM) containing bone morphogenetic proteins (BMPs) is naturally biocompatible and can be remodeled by patients’ own bone. The major shortcoming of many of the currently used DBM gel formulations is that they have a tendency to flow, particularly if there is continuous bleeding at the application site. In this study, the physicochemical properties of human DBM were examined to improve the efficiency of DBM formulations. DBM remarkably showed higher water absorption than nondemineralized bone powder after 150 min. Hydroxyl groups in DBM appeared in fourier transform infrared analysis, although hydroxyl band in nondemineralized bone powder was not observed. The results suggested that hydrogels such as CMC, hyaluronic acid, or poloxamer as carriers can be applied for injectable DBM products, such as gel or putty types.

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Lee, Kenneth J. H., Jonathan G. Roper, and Jeffrey C. Wang. "Demineralized bone matrix and spinal arthrodesis." Spine Journal 5, no. 6 (2005): S217—S223. http://dx.doi.org/10.1016/j.spinee.2005.02.006.

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Hsu, Wellington K., and Jeffrey C. Wang. "Demineralized Bone Matrix for Spinal Arthrodesis." Seminars in Spine Surgery 18, no. 1 (2006): 22–25. http://dx.doi.org/10.1053/j.semss.2006.01.004.

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El-Chaar, Edgard S. "Demineralized Bone Matrix in Extraction Sockets." Implant Dentistry 22, no. 2 (2013): 120–26. http://dx.doi.org/10.1097/id.0b013e3182859869.

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9

Schnettler, R., E. Dingeldein, and G. Herr. "Defect filling with demineralized bone matrix." Der Orthopäde 27, no. 2 (1998): 80–88. http://dx.doi.org/10.1007/pl00003482.

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10

Sharawy, Mohamed. "Bone induction in primates by demineralized bone matrix." Journal of Oral and Maxillofacial Surgery 48, no. 5 (1990): 547. http://dx.doi.org/10.1016/0278-2391(90)90277-9.

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Dissertations / Theses on the topic "Demineralized Bone Matrix"

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Wong, Wing-kit Ricky, and 黃永傑. "The effect of demineralized intramembranous bone matrix on the healingof autogenous bone grafts." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31973061.

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Chay, Siew Han. "Vascular endothelial growth pattern during demineralized bone matrix (intramembranous bone origin) induced osteogenesis." Click to view the E-thesis via HKUTO, 1999. http://sunzi.lib.hku.hk/HKUTO/record/B38628417.

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謝秀嫻 and Siew Han Chay. "Vascular endothelial growth pattern during demineralized bone matrix (intramembranous bone origin) induced osteogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B38628417.

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Wong, Wing-kit Ricky. "The effect of demineralized intramembranous bone matrix on the healing of autogenous bone grafts." Click to view the E-thesis via HKUTO, 1999. http://sunzi.lib.hku.hk/hkuto/record/B31973061.

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IWATA, HISASHI, MINORU UEDA, KAZUHIKO MERA, and HIDEKI MIZUTANI. "A STUDY OF THE BONE MORPHOGENETIC PROTEIN DERIVED FROM BOVINE DEMINERALIZED DENTIN MATRIX." Nagoya University School of Medicine, 1996. http://hdl.handle.net/2237/16100.

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6

周明忠 and Ming-chung Chow. "The healing of endochondral bone grafts in the presence of the demineralized intramembranous bone matrix: :a qualitative andquantitative analysis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B38628429.

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Chow, Ming-chung. "The healing of endochondral bone grafts in the presence of the demineralized intramembranous bone matrix :a qualitative and quantitative analysis." Click to view the E-thesis via HKUTO, 1999. http://sunzi.lib.hku.hk/HKUTO/record/B38628429.

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8

Blice, Rebecca L. "EFFICACY OF DEMINERALIZED BONE MATRIX AS AN OSTEOINDUCTIVE AGENT WHEN USING A BETA-TRICALCIUM PHOSPHATE CARRIER." University of Akron / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=akron1162918440.

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Stoianovici, Charles. "Directing Mesenchymal Stem Cells for Periodontal Regeneration." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5335.

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Background: Directing autogenous Mesenchymal Stem Cell (MSC) to defect sites has a great promise in bone regeneration. We designed a MSC specific, bone affinity peptide (E7HA7) by conjugating E7 with a polyglutamate hydroxyapatite (HA) binding motif. We sought to characterize the in-vivo releasing pattern and bioactivity of E7HA7. Methods: HA discs were coated with fluorescent labeled peptides E7HA7, E7HA2 or E7 were subcutaneously implanted in Sprague Dawley rats. In an ectopic bone formation model was used to test the in-vivo bioactivity of E7HA7 conjugated to DBM. Results: E7HA7 showed slower peptide release from scaffolds in comparison to other groups, being statistically significant at week 2 compared to E7, and to E7HA2 at week 4 and 8. In ectopic model, the medians for new bone formation in each group were: iDBM=0.041mm3, iDBM-E7=0.071mm3, aDBM=0.138mm3, and aDBM-E7=0.192mm3. Conclusions: Conjugation of E7 to polyglutamate bone binding domain showed slow releasing kinetics and osteoinductive potential.

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Jackson, Michael T. 1969. "Assessment of the closure of critical sized defects in the rabbit calvarium utilizing demineralized bone matrix putty as an allogenic graft material." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78389.

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Closure of bone defects that do not heal spontaneously require some form of bone inducing agent in order to ensure complete repair. Autogenous bone is the clinical gold standard for the management of these types of defects. Present research is aimed at finding acceptable alternatives to harvesting autogenous bone grafts in patients for obvious reasons. Recent literature supports that demineralized bone matrix (DBM) is osteoinductive, although this is not the case for all commercially available forms of DBM.
An in vivo study was conducted which attempted to evaluate the healing of critical sized defects in New Zealand white rabbit calvarium using various grafting materials. By combining demineralized bone matrix and a poloxamer gel carrier, a putty-like material that is surgically convenient can be delivered to these defects and allowed to heal.

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Books on the topic "Demineralized Bone Matrix"

1

Lindholm, T. Sam. Skeletal Reconstruction and Bioimplantation: Demineralized Bone Matrix, Non-Collagenous, Native, and Recombinant Bonemorphogenetic Proteins (Medical Intelligence Unit). R G Landes Co, 1997.

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Book chapters on the topic "Demineralized Bone Matrix"

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Hari Reddi, A., and Ryosuke Sakata. "Demineralized Bone Matrix: A Morphogenetic Extracellular Matrix." In Biomaterials from Nature for Advanced Devices and Therapies. John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781119126218.ch13.

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Seo, Seog Jin, Seok Beom Song, Ji Hwa Chae, et al. "Hydroxyl Groups in Demineralized Bone Matrix." In Advanced Biomaterials VII. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.381.

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Kim, Su-Gwan, and Ji-Su Oh. "5. Demineralized Bone Matrix (DBM) and Bone Grafts." In Translating Biomaterials for Bone Graft. CRC Press, 2016. http://dx.doi.org/10.1201/9781315363530-6.

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Kim, Yu Han, Mi Hee Cho, In Bum Song, et al. "Injectable Chitosan Carrier for Demineralized Bone Matrix." In Advanced Biomaterials VII. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.177.

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Lindholm, T. S., and P. Ragni. "Experimental Spinal Fusion Using Demineralized Bone Matrix, Bone Marrow and Hydroxyapatite." In Bone Transplantation. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83571-1_45.

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Wolfinbarger, Lloyd, Liisa M. Eisenlohr, and Katrina Ruth. "Demineralized Bone Matrix: Maximizing New Bone Formation for Successful Bone Implantation." In Musculoskeletal Tissue Regeneration. Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-239-7_6.

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Albert, T. J., I. A. Guterman, C. L. Morton, J. Lank, and R. E. McLaughlin. "Demineralized Bone Matrix Induced Protein Synthesis and Bone Formation in Canine Muscle." In Bone Transplantation. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83571-1_37.

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8

Kim, J. T., H. J. Kang, H. N. Kim, et al. "Ectopic Osteoinduction by Variously Demineralized Allogenic Cortical Bone Matrix." In Advanced Biomaterials VII. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.105.

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Cui, Lei, Dong Li, Xiang Dong Liu, Fanfan Chen, Wei Liu, and Yi Lin Cao. "Experimental Study of Partially Demineralized Bone Matrix as Bone Tissue Engineering Scaffold." In Advanced Biomaterials VI. Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-967-9.63.

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Lee, Kang Yong, Y. W. Lee, M. Park, et al. "Preparation of Caclium Phosphate Paste Composites with Demineralized Bone Matrix." In Key Engineering Materials. Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-422-7.803.

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Conference papers on the topic "Demineralized Bone Matrix"

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Jayasuriya, A. Champa, Elisabeth Michels, and Nabil A. Ebraheim. "Demineralized Bone Matrix Incorporated PLGA Matrices." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-14796.

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Poly(lactic-co-glycolic acid)-PLGA (85:15) films incorporated with demineralized bone matrix (DBM) powder with the weight ratio of polymer: DBM (75:25) were investigated for release of agents including osteoinductive (OI) factors during the 80 day period exposing to Phosphate Buffered Saline (PBS) at 37 °C. The release amount of agents including OI factors from DBM/PLGA matrices were more than 2-fold higher at 70 days than at 10 days, respectively. This result demonstrated that controlled release of OI factors can be achieved for extended time period at target site using PLGA as a carrier for DBM powder. Murine Bone Marrow Stromal Cell (BMSC) attachment was studied with different time points at 30 min, 1 h, 2 h, 4 h, 6 h and 24 h for DBM/PLGA and PLGA control matrices. Significantly higher number of BMSCs was attached to the DBM/PLGA matrices at each time points compared with controls. This result suggests that BMSCs favor to attach the surfaces having OI properties. If DBM is incorporated into biodegradable 3-D polymer scaffolds and culture with BMSCs, those scaffolds could be potentially used for bone tissue engineering applications.

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Kirilova, I. A., Yu P. Sharkeev, S. V. Nikolaev, et al. "Physicomechanical properties of the extracellular matrix of a demineralized bone." In PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS (PC’16): Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. Author(s), 2016. http://dx.doi.org/10.1063/1.4960246.

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Xie, Zhao, Fei Luo, Jian-Zhong Xu, and Shi-wu Dong. "Repaire of Large Segmental Bone Defects by Marrow Stromal Cells Transplant with Demineralized Bone Matrix." In 2008 2nd International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2008. http://dx.doi.org/10.1109/icbbe.2008.255.

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Reports on the topic "Demineralized Bone Matrix"

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Taylor, Nathan L., Frank J. Raia, Benton E. Heyworth, and Melvin P. Rosenwasser. Treatment of Humeral Nonunions With Cancellous Allograft, Demineralized Bone Matrix, and Plate Fixation. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada425546.

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