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Journal articles on the topic 'Deming regression'

Author: Grafiati

Published: 7 June 2025

Last updated: 17 July 2025

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1

Adarkwa, Samuel Akwasi, Frank Kofi Owusu, and Samuel Okyere. "Impact of Using Double Positive Samples in Deming Regression." International Journal of Mathematics and Mathematical Sciences 2022 (August 12, 2022): 1–8. http://dx.doi.org/10.1155/2022/3984857.

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In the method comparison approach, two measurement errors are observed. The classical regression approach (linear regression) method cannot be used for the analysis because the method may yield biased and inefficient estimates. In view of that, the Deming regression is preferred over the classical regression. The focus of this work is to assess the impact of censored data on the traditional regression, which deletes the censored observations compared to an adapted version of the Deming regression that takes into account the censored data. The study was done based on simulation studies with NLM

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2

Dhanoa, M. S., and R. Sanderson. "Comment on “The structural relationship: regression in biology”." Canadian Journal of Zoology 88, no. 8 (2010): 821–23. http://dx.doi.org/10.1139/z10-050.

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Supplementary information relevant to structural relationship regression in biology as discussed by McArdle (1988; Can. J. Zool. 66(11): 2329–2339) is presented. Although McArdle presented both linear and multiple linear regression models, we limit our comment to the linear model only. McArdle’s eq. 2 is corrected. Deming’s alternative form of the maximum likelihood (ML) solution (Deming 1943; Statistical adjustment of data. John Wiley and Sons, Inc., New York) is introduced. In the ML solution, the ratio of the mean measurement variances of the y and x variables is assumed constant over the r

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Bazilevskiy, Mikhail. "ANALYTICAL DEPENDENCES FOR SOME ADEQUACY CRITERIA OF DEMING REGRESSION MODEL." Proceedings of Irkutsk State Technical University 117, no. 10 (2016): 81–89. http://dx.doi.org/10.21285/1814-3520-2016-10-81-89.

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Martin, Robert F. "General Deming Regression for Estimating Systematic Bias and Its Confidence Interval in Method-Comparison Studies." Clinical Chemistry 46, no. 1 (2000): 100–104. http://dx.doi.org/10.1093/clinchem/46.1.100.

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Abstract Background: Various forms of least-squares regression analyses are used to estimate average systematic error (bias) and its confidence interval in method-comparison studies. When assumptions that underlie a particular regression method are inappropriate for the data, errors in estimated statistics result. In this report, I present an improved method for regression analysis that is free from the usual simplifying assumptions and is generally applicable to linearly related method-comparison data. Methods: Theoretical equations based on the Deming approach, further developed by physicist

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Linnet, Kristian. "Performance of Deming regression analysis in case of misspecified analytical error ratio in method comparison studies." Clinical Chemistry 44, no. 5 (1998): 1024–31. http://dx.doi.org/10.1093/clinchem/44.5.1024.

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Abstract Application of Deming regression analysis to interpret method comparison data presupposes specification of the squared analytical error ratio (λ), but in cases involving only single measurements by each method, this ratio may be unknown and is often assigned a default value of one. On the basis of simulations, this practice was evaluated in situations with real error ratios deviating from one. Comparisons of two electrolyte methods and two glucose methods were simulated. In the first case, misspecification of λ produced a bias that amounted to two-thirds of the maximum bias of the ord

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6

Zrikem, Hind, Soumia Nachate, Ibtissam Mhirig, Saliha Chellak, and Abderrahman Boukhira. "Serum creatinine and urea assays on Atellica® CH and Architect® ci4100: method comparison." European Journal of Biological Research 13, no. 1 (2023): 1–9. https://doi.org/10.5281/zenodo.7542158.

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Serum creatinine and urea are markers of renal function usually measured in conjunction. This study aims to evaluate the comparability of a new analyzer incorporated to our laboratory, Atellica® with the established analyzer, Architect ® ci 4100 in serum creatinine and urea assays. We ran 110 tests for creatinine and 107 for urea. In both analyzers, serum creatinine assay is based on the Jaffe reaction while urea measurement is based on the Roch-Ramel enzymatic reaction. Linear association between methods was evaluated using Pearson's correlation coefficient. Methods comparability

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Yeo, Chin-Pin, Carol Hui-Chen Tan, and Edward Jacob. "Haemoglobin A1c: evaluation of a new HbA1c point-of-care analyser Bio-Rad in2it in comparison with the DCA 2000 and central laboratory analysers." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 46, no. 5 (2009): 373–76. http://dx.doi.org/10.1258/acb.2009.009008.

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Background Point-of-care-testing (POCT) of haemoglobin Alc (HbA1c) is popular due to its fast turnaround of results in the outpatient setting. The aim of this project was to evaluate the performance of a new HbA1c POCT analyser, the Bio-Rad in2it, and compare it with the Siemens DCA 2000, Bio-Rad Variant II and Roche Tina-quant HbA1c Gen 2 assay on the cobas c501. Methods Imprecision of the four methods were compared by computing total imprecision from within-run and between-run data. A total of 80 samples were also compared and analysed by Deming regression and Altman–Bland difference test. R

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Mercader, Josep V., Antonio Abad-Fuentes, Consuelo Agulló, Antonio Abad-Somovilla, and Francesc A. Esteve-Turrillas. "Development of a sensitive and specific enzyme-linked immunosorbent assay for the determination of fludioxonil residues in fruit juices." Anal. Methods 6, no. 22 (2014): 8924–29. http://dx.doi.org/10.1039/c4ay01756k.

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The generation and performance of the first-ever described monoclonal antibodies to fludioxonil are herein reported, and a competitive immunoassay was developed and validated for residue analysis in fruit juices by comparison with GC-MS using Deming regression and Bland–Altman analyses.

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Payne, R. B. "Method Comparison: Evaluation of Least Squares, Deming and Passing/Bablok Regression Procedures Using Computer Simulation." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 34, no. 3 (1997): 319–20. http://dx.doi.org/10.1177/000456329703400317.

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10

Bazilevskiy, Mikhail P. "Multi-criteria approach to pair-multiple linear regression models constructing." Izvestiya of Saratov University. New Series. Series: Mathematics. Mechanics. Informatics 21, no. 1 (2021): 88–99. http://dx.doi.org/10.18500/1816-9791-2021-21-1-88-99.

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A pair-multiple linear regression model which is a synthesis of Deming regression and multiple linear regression model is considered. It is shown that with a change in the type of minimized distance, the pair-multiple regression model transforms smoothly from the pair model into the multiple linear regression model. In this case, pair-multiple regression models retain the ability to interpret the coefficients and predict the values of the explained variable. An aggregated quality criterion of regression models based on four well-known indicators: the coefficient of determination, Darbin – Wats

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11

Shrestha, Luna, Boris Kulig, Roberto Moscetti, et al. "Comparison between Hyperspectral Imaging and Chemical Analysis of Polyphenol Oxidase Activity on Fresh-Cut Apple Slices." Journal of Spectroscopy 2020 (June 29, 2020): 1–10. http://dx.doi.org/10.1155/2020/7012525.

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The assessment of the quality of fresh-cut apple slices is important for processing, storage, market value, and consumption. Determination of polyphenol oxidase activity (PPO) in apples is critical for controlling the quality of the final product (i.e., dried apples and juices). Hyperspectral imaging (HSI) is a nondestructive, noncontact, and rapid food quality assessment technique. It has the potential to detect physical and chemical quality attributes of foods such as PPO of apple. The aim of this study was to investigate the suitability of HSI in the visible and near-infrared (VIS-NIR) rang

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Mrázová, Viera, Ján Mocák, Adriána Bednárová, and Ján Balla. "Comparison of IFCC and NGSP methods for determination of glycated haemoglobin using advanced regression techniques." Open Chemistry 8, no. 6 (2010): 1216–22. http://dx.doi.org/10.2478/s11532-010-0096-x.

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AbstractThe objective of this work was a correct statistical comparison of two assay methods for determination of glycated haemoglobin HbA1c. The immunoturbidimetric determination of HbA1c was performed in two ways: using an automatic analyser Hitachi 912, calibrated according to the IFCC reference system (International Federation of Clinical Chemistry and Laboratory Medicine) and using an analyser Advia 1200 and the NGSP reference system (National Glycohaemoglobin Standardization Program). For statistical comparison of these two analytical methods several advanced regression methods were used

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Stone, M. J., P. E. Chowdrey, P. Miall, and C. P. Price. "Validation of an enzymatic total magnesium determination based on activation of modified isocitrate dehydrogenase." Clinical Chemistry 42, no. 9 (1996): 1474–77. http://dx.doi.org/10.1093/clinchem/42.9.1474.

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Abstract We have evaluated an enzymatic assay for the determination of Mg in serum, based on the activation of a chemically modified form of isocitrate dehydrogenase by Mg2+. In the presence of potassium isocitrate and NADP+, NADPH, which absorbs light at 340 nm, is produced, and its increase is proportional to Mg2+ in the sample. We have shown linearity to at least 5 mmol/L Mg and good precision by within-run CVs between 1.4% and 3.5% and day to day CVs between 3.2% and 5.4%. The method (y) is accurate, comparing well with the xylidyl blue method (x), with a Deming regression of y = 0.930x -

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Proverbio, Daniela, Roberta Perego, Eva Spada, Giada Bagnagatti de Giorgi, Angelo Belloli, and Davide Pravettoni. "Comparison of VIDAS and Radioimmunoassay Methods for Measurement of Cortisol Concentration in Bovine Serum." Scientific World Journal 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/216569.

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Radioimmunoassay (RIA) is the “gold standard” method for evaluation of serum cortisol concentration. The VIDAS cortisol test is an enzyme-linked fluorescent assay designed for the MiniVidas system. The aim of this study was to compare the VIDAS method with RIA for measurement of bovine serum cortisol concentration. Cortisol concentrations were evaluated in 40 cows using both VIDAS and RIA methods, the latter as the reference method. A paired Student’s -test, Pearson’s correlation analysis, Bland-Altman plot, and Deming regression analysis were used to compare the two methods. There was no stat

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15

Erilli, Necati Alp. "Uç Değerli Verilerde Tip-II Regresyon Yöntemlerinin Performansları." Turkish Journal of Statistics and Data Science 01, no. 1 (2025): 1–13. https://doi.org/10.5281/zenodo.15364611.

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Renuka, M., and G. Mary Valantina. "Deep Neural Learning based Deming Regression Adder Enhancement on Digital Multiplier for 3D Graphical Applications in VLSI Circuits." International Journal of Electrical and Electronics Research 11, no. 2 (2023): 242–52. http://dx.doi.org/10.37391/ijeer.110202.

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This work aims to investigate 3D Technology to provide better performance enhancement for several generations. The three-dimensional integrated circuit allows better integration density, faster on-chip communications, and heterogeneous integration. The goal of this research is to reduce time consumption and power consumption by introducing the Deep Neural Learnt Deming Regression Based Ladner-Fisher Adder Enhancement (DNLDR-LFAE) Technique in VLSI circuits. Input information (carry inputs) is taken for input layer and transmits to hidden layer 1. Deeming regression analysis has performed at hi

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Elsharif, A., and A. Don-Wauchope. "METHOD VALIDATION STUDY TO EVALUATE THE ANALYTICAL PERFORMANCE OF THE STAT–SITE METER FOR THE MEASURMENT OF SERUM BETA-HYDROXYBUTRATE." Clinical & Investigative Medicine 32, no. 6S (2009): 4. http://dx.doi.org/10.25011/cim.v32i6s.11139.

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Objectives: To evaluate the analytical performance of the STAT-Site meter (Stanbio laboratory USA) for the measurement of serum beta-hydroxybutyrate (? OH-B) concentration. Methods: The precision was evaluated using two levels of quality control materials (low and high). Within run and between run precision studies were performed. CVs (coefficient of variation) compared against accepted standards. Fifty-one leftover patient samples with previously reported ? OH-B concentrations were used for the method comparison. The accuracy was evaluated and compared to our current laboratory method, (Wako

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Yasar, Seyma, Saim Yologlu, Ramazan Altintas, Ayse Akatli, and Leyla Karaca. "The evaluation of agreement between the measurement methods used in the diagnosis of prostate cancer with the statistical methods." Medicine Science | International Medical Journal 13, no. 1 (2024): 131. http://dx.doi.org/10.5455/medscience.2023.10.205.

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The aim of this study is to evaluate the compatibility of the "Computed Tomography (CT)" and "Magnetic Resonance (MR)" methods which are imaging techniques used to describe prostate cancer with the pathology accepted as the reference method. In this study, the concordance between CT and MR results and pathology results of 37 prostate cancer patients was evaluated using the Bland-Altman, Interclass Correlation Coefficient, Concordance Correlation Coefficient, Deming Regression and Passing-Bablok method comparison methods. Inter-class correlation coefficient and Concordance Correlation Coefficie

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Mikkonen, Santtu, Mikko R. A. Pitkänen, Tuomo Nieminen, et al. "Technical note: Effects of uncertainties and number of data points on line fitting – a case study on new particle formation." Atmospheric Chemistry and Physics 19, no. 19 (2019): 12531–43. http://dx.doi.org/10.5194/acp-19-12531-2019.

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Abstract. Fitting a line to two measured variables is considered one of the simplest statistical procedures researchers can carry out. However, this simplicity is deceptive as the line-fitting procedure is actually quite a complex problem. Atmospheric measurement data never come without some measurement error. Too often, these errors are neglected when researchers make inferences from their data. To demonstrate the problem, we simulated datasets with different numbers of data points and different amounts of error, mimicking the dependence of the atmospheric new particle formation rate (J1.7) o

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Asif, Maryam, Sarah E. Groboske, Edward K. Y. Leung, Kiang-Teck J. Yeo, and Xander M. R. van Wijk. "Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding." Journal of Applied Laboratory Medicine 4, no. 2 (2019): 247–53. http://dx.doi.org/10.1373/jalm.2018.028415.

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Abstract Background The interest for vitamin D has exponentially increased testing demand for 25-hydroxy vitamin D [25(OH)D]. Consequently, many laboratories are switching from LC-MS/MS methods to automated, high-throughput immunoassays. One of the major potential issues with these assays has been the lack of cross-reactivity with 25(OH)D2. Methods We have evaluated the Roche Elecsys vitamin D total II assay for accuracy by comparing 79 patient samples with LC-MS/MS. The cross-reactivity for 25(OH)D2 was evaluated by analyzing samples with high 25(OH)D2 separately and estimating 25(OH)D2 recov

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Green, Benjamin Paul, Javier Thomas Gonzalez, Kevin Thomas, Emma Stevenson, and Penny Louise Sheena Rumbold. "Agreement between fingertip-capillary and antecubital-venous appetite-related peptides." Endocrine Connections 3, no. 4 (2014): 233–42. http://dx.doi.org/10.1530/ec-14-0110.

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This study examined the agreement between fingertip-capillary and antecubital-venous measures of appetite-related peptides. Simultaneous fingertip-capillary and antecubital-venous blood samples were collected from 19 participants. The samples were obtained at baseline, 30, 60, 90, and 120 min following breakfast for the determination of plasma GLP17–36, glucagon, insulin and leptin. Between-day reproducibility of fingertip-capillary-derived estimates was assessed in 18 participants. Deming regression, limits of agreement (LOA) and typical error as a coefficient of variation (CV) were used to q

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Arikan, Ayse, Murat Sayan, and Osman Doluca. "NeuMoDx random access molecular diagnostic system for detection and quantification of hepatitis B virus in clinical samples." Journal of Infection in Developing Countries 14, no. 10 (2020): 1197–203. http://dx.doi.org/10.3855/jidc.12659.

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Introduction: Currently, several molecular assays are available to detect and quantify HBV DNA in clinical samples. We aimed to characterize and compare the clinical performance of newly designed NeuMoDx PCR to the existing artus PCR. Methodology: The plasma HBV DNA levels of 96 clinical and 5 external quality control samples were measured by NeuMoDx and artus assays simultaneously in Kocaeli University, Turkey. The linearity, agreement and the correlation between two assays were determined by Deming regression analysis, Bland-Altman plotting, the chi-square and the relative absolute err

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Misyura, Maksym, Mahadeo A. Sukhai, Vathany Kulasignam, Tong Zhang, Suzanne Kamel-Reid, and Tracy L. Stockley. "Improving validation methods for molecular diagnostics: application of Bland-Altman, Deming and simple linear regression analyses in assay comparison and evaluation for next-generation sequencing." Journal of Clinical Pathology 71, no. 2 (2017): 117–24. http://dx.doi.org/10.1136/jclinpath-2017-204520.

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AimsA standard approach in test evaluation is to compare results of the assay in validation to results from previously validated methods. For quantitative molecular diagnostic assays, comparison of test values is often performed using simple linear regression and the coefficient of determination (R2), using R2 as the primary metric of assay agreement. However, the use of R2 alone does not adequately quantify constant or proportional errors required for optimal test evaluation. More extensive statistical approaches, such as Bland-Altman and expanded interpretation of linear regression methods,

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Wu, Cheng, and Jian Zhen Yu. "Evaluation of linear regression techniques for atmospheric applications: the importance of appropriate weighting." Atmospheric Measurement Techniques 11, no. 2 (2018): 1233–50. http://dx.doi.org/10.5194/amt-11-1233-2018.

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Abstract. Linear regression techniques are widely used in atmospheric science, but they are often improperly applied due to lack of consideration or inappropriate handling of measurement uncertainty. In this work, numerical experiments are performed to evaluate the performance of five linear regression techniques, significantly extending previous works by Chu and Saylor. The five techniques are ordinary least squares (OLS), Deming regression (DR), orthogonal distance regression (ODR), weighted ODR (WODR), and York regression (YR). We first introduce a new data generation scheme that employs th

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Khan, Imran Ahmad, Sajid N. A. Nomani, Debasish Mishra, Amit Yadav, Sayantika Sarkar, and Sonal Patnaik. "Comparison of Point of Care Versus Laboratory Autoanalyzer Measurements of Sodium and Potassium Levels in Patients Admitted from the Emergency Department." Indian Journal of Emergency Medicine 8, no. 1 (2022): 9–14. http://dx.doi.org/10.21088/ijem.2395.311x.8122.1.

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Electrolyte problems are one of the most common cause of morbidity and mortality in the sick patients coming to the Emergency. Electrolytes measured in central lab usually takes 30-60 minutes or more whereas point of care device can give results within 5 to 10 minutes, however different instruments available and their values varies accordingly. Therefore, this study was done to investigate whether electrolyte i.e. sodium and potassium levels assessed using point of care device and auto analysers were equivalent. Methods: We prospectively studied patients admitted from Emergency Department betw

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Angrist, Joshua, Peter Hull, Parag Pathak, and Christopher Walters. "Interpreting Tests of School VAM Validity." American Economic Review 106, no. 5 (2016): 388–92. http://dx.doi.org/10.1257/aer.p20161080.

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We develop over-identification tests that use admissions lotteries to assess the predictive value of regression-based value-added models (VAMs). These tests have degrees of freedom equal to the number of quasi-experiments available to estimate school effects. By contrast, previously implemented VAM validation strategies look at a single restriction only, sometimes said to measure forecast bias. Tests of forecast bias may be misleading when the test statistic is constructed from many lotteries or quasi-experiments, some of which have weak first stage effects on school attendance. The theory dev

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Linnet, Kristian. "Necessary Sample Size for Method Comparison Studies Based on Regression Analysis." Clinical Chemistry 45, no. 6 (1999): 882–94. http://dx.doi.org/10.1093/clinchem/45.6.882.

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Abstract Background: In method comparison studies, it is of importance to assure that the presence of a difference of medical importance is detected. For a given difference, the necessary number of samples depends on the range of values and the analytical standard deviations of the methods involved. For typical examples, the present study evaluates the statistical power of least-squares and Deming regression analyses applied to the method comparison data. Methods: Theoretical calculations and simulations were used to consider the statistical power for detection of slope deviations from unity a

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ADASZEK, ŁUKASZ, OLIWIER TEODOROWSKI, MARTA STANIEC, et al. "Comparison of the Vcheck and IMMULITE 2000 methods for T4 measurement in canine and feline serum." Medycyna Weterynaryjna 78, no. 03 (2022): 6632–2022. http://dx.doi.org/10.21521/mw.6632.

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The aim of this study was to compare canine and feline thyroxine (T4) results obtained by the Vcheck method with those obtained by the IMMULITE 2000 immunoassay, which had previously been validated for canine serum. The concentration of T4 in 53 canine and 44 feline serum samples was determined concurrently by the Vcheck and IMMULITE methods, the latter as the reference method. The T4 values were compared using the IMMULITE Youden plot and Deming regression analysis. According to the regression analysis, the two methods gave comparable results. Spearman’s correlation shows a very high consiste

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Fung, Angela W. S., Michael J. Knauer, Ivan M. Blasutig, David A. Colantonio, and Vathany Kulasingam. "Evaluation of electrochemiluminescence immunoassays for immunosuppressive drugs on the Roche cobas e411 analyzer." F1000Research 6 (October 13, 2017): 1832. http://dx.doi.org/10.12688/f1000research.12775.1.

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Background: Therapeutic drug monitoring of immunosuppressant drugs are used to monitor drug efficacy and toxicity and to prevent organ transplantation rejection. This study evaluates the analytical performance of semi-automated electrochemiluminescence immunoassays (ECLIA) for cyclosporine (CSA), tacrolimus (TAC) and sirolimus (SRL) on the Roche cobas e 411 analyzer at a major transplant hospital to identify method suitability and limitations. Methods: Residual whole blood samples from patients undergoing immunosuppressant therapy were used for evaluation. Experiments included imprecision, lin

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Fung, Angela W. S., Michael J. Knauer, Ivan M. Blasutig, David A. Colantonio, and Vathany Kulasingam. "Evaluation of electrochemiluminescence immunoassays for immunosuppressive drugs on the Roche cobas e411 analyzer." F1000Research 6 (December 12, 2017): 1832. http://dx.doi.org/10.12688/f1000research.12775.2.

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Background: Therapeutic drug monitoring of immunosuppressant drugs are used to monitor drug efficacy and toxicity and to prevent organ transplant rejection. This study evaluates the analytical performance of semi-automated electrochemiluminescence immunoassays (ECLIA) for cyclosporine (CSA), tacrolimus (TAC) and sirolimus (SRL) on the Roche cobas e 411 analyzer at a major transplant hospital to assess method suitability and limitations. Methods: Residual whole blood samples from patients undergoing immunosuppressant therapy were used for evaluation. Imprecision, linearity, functional sensitivi

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Doddamani, Parveen, Kusuma Kasapura Shivashankar, Shobha Chikkavaddaragudi Ramachandra, Insha Aman, and Suma Maduvanahalli Nataraj. "Agreement of Measurement between Arterial and Venous Electrolyte Levels in Neonates in a Tertiary Care Hospital." Journal of Laboratory Physicians 12, no. 01 (2020): 20–26. http://dx.doi.org/10.1055/s-0040-1713061.

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Abstract Context Venous or arterial blood is used for the estimation of electrolytes in neonates in neonatal intensive care unit (NICU). In addition to the measurement of blood gases and bicarbonate in the arterial blood, arterial blood gas analysis also estimates electrolytes thus circumventing the need to collect a venous sample for electrolytes. The literature survey revealed studies comparing the electrolyte levels in arterial and venous blood in adults and older children, but to our knowledge none were found in neonates, hence the study. Aims The aim of the study is to compare the electro

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Базилевский, М. П. "SYNTHESIS OF LINEAR REGRESSION MODEL AND EIV-MODEL." МОДЕЛИРОВАНИЕ, ОПТИМИЗАЦИЯ И ИНФОРМАЦИОННЫЕ ТЕХНОЛОГИИ 7, no. 1(24) (2019): 33–34. http://dx.doi.org/10.26102/2310-6018/2019.24.1.033.

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Данная работа посвящена синтезу модели парной линейной регрессии и простейшей EiV-модели (Errors-In-Variables model), более известной как регрессия Деминга. EIV-модель – это регрессия, в которой все переменные содержат случайные ошибки. Такие модели имеют ряд существенных недостатков, что затрудняет работу с ними. Предлагаемый в работе синтез, названный двухфакторной моделью полносвязной линейной регрессии, не только лишен этих недостатков, но и имеет определенные достоинства. Рассмотрены основные этапы построения и анализа двухфакторных моделей полносвязной линейной регрессии. Предложенная мо

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Stöckl, Dietmar, Katy Dewitte, and Linda M. Thienpont. "Validity of linear regression in method comparison studies: is it limited by the statistical model or the quality of the analytical input data?" Clinical Chemistry 44, no. 11 (1998): 2340–46. http://dx.doi.org/10.1093/clinchem/44.11.2340.

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Abstract We compared the application of ordinary linear regression, Deming regression, standardized principal component analysis, and Passing–Bablok regression to real-life method comparison studies to investigate whether the statistical model of regression or the analytical input data have more influence on the validity of the regression estimates. We took measurements of serum potassium as an example for comparisons that cover a narrow data range and measurements of serum estradiol-17β as an example for comparisons that cover a wide data range. We demonstrate that, in practice, it is not the

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Базилевский, М. П. "INVESTIGATION OF A TWO-FACTOR FULLY CONNECTED LINEAR REGRESSION MODEL." МОДЕЛИРОВАНИЕ, ОПТИМИЗАЦИЯ И ИНФОРМАЦИОННЫЕ ТЕХНОЛОГИИ 7, no. 2(25) (2019): 80–96. http://dx.doi.org/10.26102/2310-6018/2019.25.2.008.

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Данная работа посвящена исследованию модели полносвязной линейной регрессии, представляющей собой синтез модели парной линейной регрессии и регрессии Деминга. Если множественная регрессия строится по принципу «независимые переменные влияют на зависимую», то принципом полносвязной регрессии является «все переменные влияют друг на друга». Полносвязная регрессия достаточно просто оценивается, лишена эффекта мультиколлинеарности, имеет гораздо более разнообразную интерпретацию, чем множественная регрессия, и пригодна для прогнозирования. Однако при построении полносвязной регрессии неизвестным ост

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Huang, C. M., and M. Zweig. "Evaluation of a radioimmunoassay of urinary cortisol without extraction." Clinical Chemistry 35, no. 1 (1989): 125–26. http://dx.doi.org/10.1093/clinchem/35.1.125.

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Abstract We evaluated the Kallestad "Quanticoat" cortisol RIA for direct (no extraction) measurement of urinary free cortisol, which requires no solvent extraction. An analytical-recovery study showed a linear regression of y (measured) = 0.65x (added) + 37.5 micrograms/L (Sy.x = 21.4 micrograms/L, r = 0.978, n = 48). Recovery appeared to vary with the urine used and with the concentrations of cortisol added. Within- and between-run CVs were less than or equal to 4.1% and less than or equal to 3.8%, respectively. Cross reactivities were low, except for prednisolone (20.5%). This no-extraction

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Wen, Dong-Mei, Sheng-Nan Xu, Wei-Jia Wang, Xiu-Ming Zhang, Ming-Huan Suo, and De-Cai Zhang. "Evaluation of the Interference of Hemoglobin Variant J-Bangkok on Glycated Hemoglobin (HbA1c) Measurement by Five Different Methods." Experimental and Clinical Endocrinology & Diabetes 125, no. 10 (2017): 655–60. http://dx.doi.org/10.1055/s-0043-118535.

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Abstract Objective The interference of the hemoglobin variant (Hb J-Bangkok) was evaluated on 4 different glycated hemoglobin assays and compared with a reference immuno assay. Methods An overall test of coincidence of 2 least-squares linear regression lines was performed to determine whether the presence of Hb J-Bangkok caused a statistically significant difference in HbA1c results compared with a reference immuno assay. Statistical analysis was performed on the difference of the estimated average glucose calculated from HbA1c values and fasting plasma glucose in the Hb J-Bangkok variant grou

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Seemann-Sinn, Alexander, Peter Rüdrich, Tom Gorges, Ingo Sandau, Falk Naundorf, and Bernd Wolfarth. "Determining Physiological and Energetic Demands during High-Level Pommel Horse Routines Using a Modified Method Based on Heart Rate–Oxygen Uptake Functions." Sports 12, no. 1 (2024): 27. http://dx.doi.org/10.3390/sports12010027.

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This study aimed (1) to assess the validity of a modified method (Mmod) based on heart rate (HR)—oxygen uptake (VO2) regression functions to calculate total energy costs (Wtotal) and aerobic (Waer) and anaerobic alactic energy contribution (Wpcr) and (2) to analyse the physiological and energetic demands of high-level pommel horse routines (PH routines). The Mmod was developed because VO2 measurements are limited during high-level PH routines. Answering Part 1, nine male artistic gymnasts performed a PH routine where energy costs were calculated from VO2 measurements and then compared with ene

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Sammartano, Antonino, Ruggero Buonocore, Roberto Fiorini, et al. "A Comparison Study: Possible Bias in Troponin I Measurement Obtained with a Point of Care Testing and a Central Laboratory Analyzers Employing Different Biological Matrices and Anticoagulants." Diagnostics 14, no. 14 (2024): 1482. http://dx.doi.org/10.3390/diagnostics14141482.

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Background: high-sensitive cardiac TroponinI (hs-cTnI) is widely used for diagnosis of acute coronary syndromes. The latest recommendation for hs-cTnI determination is the protocol 0–1 h finalized to improve the rule out accuracy of the test. A Point of Care Testing able to guarantee these performances could be very useful due to reducing the turnaround time and ruling out patients suspected of ACS, especially by using biological matrices that are not required for centrifuge. The aim of our work is to compare the results for hs-cTnI obtained using different biological matrices and anticoagulan

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González-Zamora, Alberto, Erick Sierra-Campos, Rebeca Pérez-Morales, et al. "Measurement of Capsaicinoids in Chiltepin Hot Pepper: A Comparison Study between Spectrophotometric Method and High Performance Liquid Chromatography Analysis." Journal of Chemistry 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/709150.

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Direct spectrophotometric determination of capsaicinoids content in Chiltepin pepper was investigated as a possible alternative to HPLC analysis. Capsaicinoids were extracted from Chiltepin in red ripe and green fruit with acetonitrile and evaluated quantitatively using the HPLC method with capsaicin and dihydrocapsaicin standards. Three samples of different treatment were analyzed for their capsaicinoids content successfully by these methods. HPLC-DAD revealed that capsaicin, dihydrocapsaicin, and nordihydrocapsaicin comprised up to 98% of total capsaicinoids detected. The absorbance of the d

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Mazlan, Mohd Zulfakar, Wan Norlina Wan Azman, Najib Majdi Yaacob, Tan Say Koon, and Nurul Khaiza Yahya. "Analytical Evaluation of Point-of-Care Finecare™ Procalcitonin Rapid Quantitative Test in Sepsis Population as Compared with Elecsys® BRAHMS Procalcitonin Immunoassay." Diagnostics 14, no. 11 (2024): 1080. http://dx.doi.org/10.3390/diagnostics14111080.

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The study compared two plasma procalcitonin (PCT) assays, the point of care (POC) Finecare™ Procalcitonin Rapid Quantitative Test and the Elecsys® BRAHMS PCT immunoassay, in sepsis ICU patients. Forty-one plasma samples were analyzed, showing a strong correlation (r = 0.98) and no significant difference in PCT values. The mean POC PCT value was 4.46 ng/mL (SD 8.68), and for laboratory BRAHMS PCT, it was 4.67 ng/mL (SD 10.03). The study found a strong linear relationship between plasma POC PCT and laboratory BRAHMS PCT (r = 0.98). Different regression methods showed varying intercepts and slope

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Kosicka, Katarzyna, Anna Siemiątkowska, Agata Szpera-Goździewicz, Mariola Krzyścin, Grzegorz Bręborowicz, and Franciszek Główka. "High-performance liquid chromatography methods for the analysis of endogenous cortisol and cortisone in human urine: comparison of mass spectrometry and fluorescence detection." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 56, no. 1 (2018): 82–89. http://dx.doi.org/10.1177/0004563218783789.

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Background The analysis of steroids in biological matrices is challenging. One can apply immunoassay as well as gas and liquid chromatography with various types of detection, depending on the available equipment and the experience of the analyst. The question is how the methods are interchangeable between themselves. Doubts were reported having compared immunoassays and chromatography-mass spectrometry, but there are scarce data on chromatographic methods with detection types other than mass spectrometry. Methods Here, we present the detailed comparison of two liquid chromatographic methods fo

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McLeish, Susan A., Kay Burt, and Kostas Papasouliotis. "Analytical quality assessment and method comparison of immunoassays for the measurement of serum cobalamin and folate in dogs and cats." Journal of Veterinary Diagnostic Investigation 31, no. 2 (2019): 164–74. http://dx.doi.org/10.1177/1040638718824073.

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Serum cobalamin and folate are often measured in cats and dogs as part of laboratory testing for intestinal disease, small intestinal dysbiosis, or exocrine pancreatic deficiency. We performed an analytical validation of human immunoassays for cobalamin and folate measurement (AIA-900 analyzer, Tosoh Bioscience) and compared results with those obtained using chemiluminescence assays (Immulite 2000 analyzer, Siemens Medical Solutions Diagnostics). Accuracy, precision, total observable error (TEobs%), and σ values were calculated for the immunoassays. Correlation and agreement were evaluated wit

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Huang, C. M., M. H. Kroll, M. Ruddel, R. G. Washburn, and J. E. Bennett. "An enzymatic method for 5-fluorocytosine." Clinical Chemistry 34, no. 1 (1988): 59–62. http://dx.doi.org/10.1093/clinchem/34.1.59.

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Abstract We developed an enzymatic method for determination of 5-fluorocytosine in serum, using creatine iminohydrolase (EC 3.5.4.21), the Cobas-Bio analyzer, and an extant ammonia method. Analytical recovery (y) of drug added to serum (x) was good, with y = 0.97x-0.7, Sy.x = 3.6, r = 0.997 (n = 65) over the range 6.25 to 150 mg/L. Comparison with an HPLC method (x) showed good agreement: y = 0.98x + 1.34, Sy.x = 3.7 (n = 37), as analyzed with the Deming debiased regression. Precision was good, CVs being less than 3% for within-run and less than 6% for between-run controls. Ammonia, amphoteric

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Press, Richard D., Dana Dressel, Michelle McBean, et al. "Evaluation of a New Closed-System Automated RT-qPCR Assay for the Rapid Detection and Monitoring of Common Nucleophosmin Mutations in Patients with Acute Myeloid Leukemia." International Journal of Molecular Sciences 25, no. 14 (2024): 7912. http://dx.doi.org/10.3390/ijms25147912.

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Quantitative assessment of nucleophosmin 1 (NPM1) mutation status is integral to evaluating measurable residual disease (MRD) in NPM1-mutated acute myeloid leukemia (AML) patients. In a retrospective study, leftover peripheral blood (PB) specimens (n = 40) which were collected for routine clinical diagnostic evaluations of AML disease burden were tested by both a novel automated RT-qPCR quantitative NPM1 assay (Xpert NPM1 mutation assay) and the NPM1 mutA, mutB&D MutaQuant kit. Based on a Deming regression analysis, there was a high correlation (slope = 0.92; intercept = 0.12; Pearson’s r

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Liu, Jiakai, Chin Hon Tan, Tze Ping Loh, and Tony Badrick. "Detecting Long-term Drift in Reagent Lots." Clinical Chemistry 61, no. 10 (2015): 1292–98. http://dx.doi.org/10.1373/clinchem.2015.242511.

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Abstract BACKGROUND Between-reagent lot verification is a routine laboratory exercise in which a set of samples is tested in parallel with an existing reagent lot and a candidate reagent lot (before the candidate lot is committed to test patient samples). The exercise aims to verify and maintain consistency in the analytical performance of a test. We examined the limitations of a routine between-reagent lot verification procedure in detecting long-term analytical drift and looked for a more sensitive alternative. METHOD Via numerical simulations, we examined the statistical power of the curren

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Ciptono, Wakhid S., Abdul Razak Ibrahim, and Ainin Sulaiman. "Mediation Analysis Using the Hierarchical Multiple Regression Technique: A Study of the Mediating Roles of World-Class Performance in Operations." Gadjah Mada International Journal of Business 12, no. 2 (2010): 139. http://dx.doi.org/10.22146/gamaijb.5509.

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The changing environment in an organization is forcing the organization to find a plan of integrated management framework and adequate performance measurement. Failure to plan basically means planning failure for the business. Finding the critical factors of quality management practices (QMP), themediating roles of the contextual factors of world-class performance in operations (i.e., world-class company practices or WCC, operational excellence practices or OE, company nonfinancial performance or CNFP), and the company financial performance would enable the company to facilitate the sustainabi

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Rodríguez-Cabaleiro, Diego, Katleen Van Uytfanghe, Veronique Stove, Tom Fiers, and Linda M. Thienpont. "Pilot Study for the Standardization of Insulin Immunoassays with Isotope Dilution–Liquid Chromatography/Tandem Mass Spectrometry." Clinical Chemistry 53, no. 8 (2007): 1462–69. http://dx.doi.org/10.1373/clinchem.2007.088393.

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Abstract Background: An international working group convened by the American Diabetes Association (ADA) called for a reference measurement procedure for use in a trueness-based standardization project of insulin immunoassays. In view of this demand, we conducted a pilot study to investigate the feasibility of such a standardization project with our isotope dilution-liquid chromatography/tandem mass spectrometry (ID-LC/tandem MS) procedure. Methods: We evaluated the precision, accuracy, and limit of quantification (LoQ) of the ID-LC/tandem MS procedure by use of insulin-free serum supplemented

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Sarıgül, Figen, Osman Doluca, Sıla Akhan, and Murat Sayan. "Investigation of compatibility of severe acute respiratory syndrome coronavirus 2 reverse transcriptase-PCR kits containing different gene targets during coronavirus disease 2019 pandemic." Future Virology 15, no. 8 (2020): 515–24. http://dx.doi.org/10.2217/fvl-2020-0169.

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Aim: In the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), reverse transcriptase-PCR (RT-PCR) technique is often used. We evaluated the compatibility of SARS-CoV-2 RT-PCR kits containing different gene targets during the pandemic. Materials & methods: Samples were tested by Bio-Speddy® ( RdRp gene) and Diagnovital® ( RdRp + E genes). The correlation between two assays were determined by Deming regression analysis and chi-square analyses. Results: Diagnovital PCR kit showed amplification in a narrow Ct range and conveniently sharper exponential amplification curv

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Bouman, A. A., C. M. de Ridder, J. H. Nijhof, J. C. Netelenbos, and H. A. Delemarre-vd Waal. "Immunoadsorption assay for bone alkaline phosphatase compared with wheat germ agglutinin precipitation assay in serum from (pre)pubertal girls." Clinical Chemistry 42, no. 12 (1996): 1970–74. http://dx.doi.org/10.1093/clinchem/42.12.1970.

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Abstract The performance characteristics of two bone alkaline phosphatase (ALP; EC 3.1.3.1) assays, a wheat germ agglutinin (WGA) precipitation assay and a new immunoadsorption assay (IAA), were compared. The within- and between-run imprecision of the IAA (3.6-4.2% and 3.6-7.7%) was comparable with that of the WGA assay. The mean cross-reactivity with liver ALP appeared to be 4% in the WGA assay and 11% in the IAA. The reference ranges in a group of 155 healthy Caucasian (pre)pubertal schoolgirls were: 149-401 U/L (total ALP, 30 degrees C), 105-349 U/L (bone ALP, 30 degrees C, WGA assay), and

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Huang, C. M. "Development and evaluation of an automated dye-binding assay for protein in cerebrospinal fluid." Clinical Chemistry 34, no. 5 (1988): 980–83. http://dx.doi.org/10.1093/clinchem/34.5.980.

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Abstract Addition of sodium dodecyl sulfate (SDS) to Coomassie Brilliant Blue reagent equalizes the binding variability of the dye to various proteins and markedly improves the accuracy of quantification of protein in cerebrospinal fluid. In the presence of SDS, the absorption spectrum and the absorption maximum are affected by reaction time and temperature, age of the dye preparation, and protein constituent. I automated this procedure, to optimize precision, enable use of a smaller sample, decrease hands-on time, maintain consistency in the time of reading, and avoid carryover. The results (

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