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Dissertations / Theses on the topic 'Dendrite differentiation'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Hattori, Yukako. "Subtype-specific postmitotic transcriptional programs controlling dendrite morphogenesis of Drosophila sensory neuron." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188831.

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Yukako Hattori, Tadao Usui, Daisuke Satoh, Sanefumi Moriyama, Kohei Shimono, Takehiko Itoh, Katsuhiko Shirahige, Tadashi Uemura, Sensory-Neuron Subtype-Specific Transcriptional Programs Controlling Dendrite Morphogenesis: Genome-wide Analysis of Abrupt and Knot/Collier, Developmental Cell, Volume 27, Issue 5, 9 December 2013, Pages 530-544, ISSN 1534-5807<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(生命科学)<br>甲第18418号<br>生博第298号<br>新制||生||39(附属図書館)<br>31276<br>京都大学大学院生命科学研究科統合生命科学専攻<br>(主査)教授上村匡, 教授西田栄介, 教授荒木崇<br>学位規則第4条第1項該当

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Santana, Themis Taynah da Silva. "Efeitos da sinaliza??o via CREB sobre a sobreviv?ncia e diferencia??o neuronal." Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17025.

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Made available in DSpace on 2014-12-17T15:28:52Z (GMT). No. of bitstreams: 1 ThemisTSS_DISSERT.pdf: 1249174 bytes, checksum: 23a39272c35586e8f475b1aa239af353 (MD5) Previous issue date: 2012-12-21<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>The cortical development requires a precise process of proliferation, migration, survival and differentiation of newly formed neurons to finally achieve the development of a functional network. Different kinases, such as PKA, CaMKII, MAPK and PI3K, phosphorylate the transcription factors CREB, and thus activate it, inducing CREB-d

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3

Zhang, Angela Leibo. "Physiologic regulation of monocyte differentiation into dendritic cells /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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4

Svitlova, Olena B. "Six-Nine Months Long Term Culture of Mouse Bone Marrow Cells Differentiated to Macrophages and Eosinophils." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1567524586159929.

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5

Chen, Yixuan. "Effect of hypoxia on dendritic cell function and differentiation." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426446.

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6

Antignano, Frann Lillis. "The role of SHIP in dendritic cell differentiation and function." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/11079.

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SHIP (SH2-containing inositol 5'-phosphatase) is a hematopoietic restricted enzyme responsible for the hydrolysis of the phosphatidylinositol 3-kinase-generated second messenger PI-3,4,5-P₃ to PI-3,4-P₂ and, thereby, negatively regulates cell survival, proliferation and differentiation. Herein, we demonstrate a role for SHIP in the differentiation and function of dendritic cells (DCs). We found that SHIP restrains in vitro generation and survival of bone marrow derived DCs cultured with granulocyte macrophage colony stimulating factor (GM-CSF) or fms-like tyrosine kinase 3 ligand (Flt3L). Th

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7

Nguyen, Kim Phung Le. "Cholera Toxin Induces cAMP-dependent Th17 Differentiation by Dendritic Cells." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1465083.

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Thesis (M.S.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed June 19, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 47-55).

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8

Yamaguchi, Yasunori. "Studies on the regulation of dendritic cell differentiation and maturation." 京都大学 (Kyoto University), 1998. http://hdl.handle.net/2433/182466.

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9

Moore, Carlene Drucilla. "The role of centaurin alpha-1 in the regulation of neuronal differentiation." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/moore.pdf.

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10

Bachy, Veronique. "Dendritic cell differentiation and activation in normal pregnancy and pre-eclampsia." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435463.

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11

Hill, Donna Monique. "Mechanism of centaurin-alpha-1 control of neuronal differentiation." Birmingham, Ala. : University of Alabama at Birmingham, 2010. https://www.mhsl.uab.edu/dt/2010m/hill.pdf.

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Thesis (M.S.)--University of Alabama at Birmingham, 2009.<br>Title from PDF t.p. (viewed June 30, 2010). Additional advisors: Lori McMahon, Stephen Watts. Includes bibliographical references (p. 31-35).

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12

Boliar, Saikat. "Pathogenesis of influenza A virus inhibition of monocyte differentiation into dendritic cell /." Lexington, Ky. : [University of Kentucky Libraries], 2009. http://hdl.handle.net/10225/1153.

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Thesis (Ph. D.)--University of Kentucky, 2009.<br>Title from document title page (viewed on May 17, 2010). Document formatted into pages; contains: viii, 107 p. : ill. (some col.). Includes abstract and vita. Includes bibliographical references (p. 92-105).

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13

Fong, Lai-ping Iris. "Modulation of dendritic cell differentiation, maturation by exogenous and endogenous "danger" signals." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31971015.

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14

Kouremenou, Chrisoula. "The effects of tick immunomodulators on human dendritic cell differentiation and function." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442819.

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15

Fong, Lai-ping Iris, and 方麗萍. "Modulation of dendritic cell differentiation, maturation by exogenous and endogenous "danger" signals." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31971015.

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16

McDermott, Jacqueline Ruth. "The influence of dendritic cells on the differentiation of T helper cells." Thesis, University of Surrey, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326509.

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17

Sun, Qian. "Cellular and molecular mechanisms of dendritic cell differentiation from cells of leukaemic origin." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38885335.

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18

Sun, Qian, and 孫倩. "Cellular and molecular mechanisms of dendritic cell differentiation from cells of leukaemic origin." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38885335.

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19

Boliar, Saikat. "PATHOGENESIS OF INFLUENZA A VIRUS: INHIBITION OF MONOCYTE DIFFERETIATION INTO DENDRITIC CELL." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/786.

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Dendritic cells (DC) are a heterogeneous population of hematopoietic cells that play a versatile role in orchestrating immune responses against an array of invading pathogens, including influenza virus. These cells reside in lymphoid organs as well as in non-lymphoid tissues such as mucosal surfaces of respiratory and gastro-intestinal system. Recent investigations have suggested that in the steady state, dendritic cells are derived mainly from bone marrow precursor cells without a monocytic intermediate whereas during inflammation or infection, monocytes readily differentiate to generate mono

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20

Klees, Johanna [Verfasser]. "The Influence of Symbiont Bacteroides vulgatus on Th17 Differentiation via Dendritic Cells / Johanna Klees." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1240673272/34.

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21

Khong, Andrea. "Effect of murine cytomegalovirus infection on haematopoiesis and myeloid cell differentiation and function." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0260.

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Cytomegalovirus (CMV) is a ubiquitous pathogen affecting over 95% of the worlds population. While infection is typically asymptomatic in healthy individuals, the virus persists life-long in its host and can be reactivated following withdrawal of immune control. As such, it remains a serious clinical concern in individuals who are immunocompromised, such as newborns and neonates, transplant and/or chemotherapy recipients, and HIV/AIDS patients. CMV also has the ability to cause immunosuppression, the mechanisms of which include defective antigen presentation to T cells and interference with ha

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22

Koper, Ewa. "Differentiation of dendrites and the analysis of spine- like structures on Lobula Plate Tangential Cells in Drosophila melanogaster." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-69244.

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23

Koper, Ewa Joanna. "Differentiation of dendrites and the analysis of spine-like structures on lobula plate tangential cells in Drosophila melanogaster." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=984614338.

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24

Yamamoto, Kazuyo. "Anti-inflammatory modulation of human myeloid-derived dendritic cell subsets by lenalidomide." Kyoto University, 2020. http://hdl.handle.net/2433/259726.

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25

Skarsvik, Susanne. "Aberrancies associated with dendritic cells and T lymphocytes in type 1 diabetes /." Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med920s.pdf.

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26

Kraus, Lea-Franziska [Verfasser]. "9-cis-retinoic acid modulates dendritic cell differentiation towards a regulatory T cell inducing phenotype / Lea-Franziska Kraus." Ulm : Universität Ulm, 2018. http://d-nb.info/1152324411/34.

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27

Musumeci, Andrea [Verfasser], Anne [Akademischer Betreuer] Krug, Thomas [Gutachter] Korn, and Roland [Gutachter] Rad. "The transcriptional landscape of plasmacytoid dendritic cell differentiation / Andrea Musumeci ; Gutachter: Thomas Korn, Roland Rad ; Betreuer: Anne Krug." München : Universitätsbibliothek der TU München, 2017. http://d-nb.info/1167926196/34.

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Hammon, Kathrin [Verfasser], and Wolfgang [Akademischer Betreuer] Herr. "IDH mutations as immune target and their effect on dendritic cell differentiation and metabolism / Kathrin Hammon ; Betreuer: Wolfgang Herr." Regensburg : Universitätsbibliothek Regensburg, 2019. http://d-nb.info/120188408X/34.

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Sekar, Divya [Verfasser], Manfred [Akademischer Betreuer] Schubert-Zsilavecz, and Bernhard [Akademischer Betreuer] Brüne. "Impact of tumour microenvironmental factors on dendritic cell differentiation and function / Divya Sekar. Gutachter: Manfred Schubert-Zsilavecz ; Bernhard Brüne." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2012. http://d-nb.info/1044412984/34.

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30

Hackett, Simon Marc. "Addressing the immunological barriers to regenerative medicine : differentiation and characterisation of dendritic cells derived from induced pluripotent stem cells." Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.644988.

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Induced pluripotent stem cells (iPS cells) have shown great promise in the newly-developing field . of regenerative medicine. Recently, however; there have been conflicting reports regarding their immunogenicity, even when derived in an autologous fashion, due to the ectopic expression of certain developmental antigens. Dendritic cells (DC) are professional antigen presenting cells and therefore serve as potential tools for modulating the immune response, particularly with respect to acceptance of stem cell-derived tissues. We hypothesised that DC differentiated from iPS cells, so-called iPS,

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31

Royle, Caroline. "Plasmacytoid dendritic cell activation and differentiation by the Human Immunodeficiency Virus type 1 and 2 : implications for HIV immunopathogenesis." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24938.

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Infection with HIV-1 results in the progressive dysfunction of the immune system eventually leading to AIDS, characterised by low CD4+ T lymphocyte counts and increased susceptibility to opportunistic infections. In contrast to HIV-1, individuals infected with HIV-2 often remain asymptomatic, with lower viral loads and higher CD4+ T cell counts throughout the course of disease. Furthermore, HIV-2+ individuals display enhanced HIV-specific T cell responses. In addition, HIV-1 disease progression is slower in patients with pre-existing HIV-2 infection. Plasmacytoid dendritic cells (pDCs) are key

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32

Ober-Blöbaum, Juliane Luise [Verfasser]. "The role of Id2 (inhibitor of differentiation/ DNA binding) in dendritic cell development in steady state and inflammation / Juliane Luise Ober-Blöbaum." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2011. http://d-nb.info/1018218734/34.

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33

Diepenbruck, Sabine [Verfasser], and Peter [Akademischer Betreuer] Nelson. "The potential impact of Wnt5a on differentiation and phenotype of dendritic cells found in renal cell carcinoma / Sabine Diepenbruck ; Betreuer: Peter Nelson." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1148276033/34.

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34

Miyamoto, Kazue. "Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4+ T cell differentiation." Kyoto University, 2010. http://hdl.handle.net/2433/120928.

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35

Gonzalez, Roberto Pereira. "Diferenciação de células mononucleares do sangue periférico humano em células dendríticas: vias de sinalização e efeitos da melatonina sobre o fenótipo e função das células in vitro." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-10122014-080728/.

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A melatonina (MLT) é um hormônio responsável pela regulação dos ritmos circadianos, com ampla atuação na fisiologia animal, incluindo os seres humanos. Sua ação moduladora sobre o sistema imune possibilitou estudar seu efeito sobre a estimulação de monócitos na diferenciação em células dendríticas (DCs). Monócitos estimulados com MLT, durante a etapa de adesão de duas horas, apresentaram aumentada presença dos receptores para citocinas GM-CSF, IL-4 e TNF-a, necessários à geração de DCs in vitro. DCs geradas sob estímulo de MLT mostraram um aumento nas moléculas de membrana como CD40, CD80 e CD

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36

Powell, Rebecca. "Synaptotoxicité dans la maladie d'Alzheimer : Influence du processing d'APP sur les synapses excitatrices Involvement of CRF2 signaling in enterocyte Differentiation." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAV051.

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La maladie d’Alzheimer (MA) est définie comme une maladie neurodégénérative où des altérations synaptiques mènent à la perte neuronale parallèlement à des défauts de mémoire et d’apprentissage. Il est établi que les dysfonctions synaptiques observées dans la MA sont initiées par les formes oligomériques du peptide β-amyloïde (Aβ), un dérivé protéolytique de l’Amyloid Precursor Protein (APP). Cependant, le chemin qu’empreinte Aβ, selon son origine intra- ou extracellulaire, afin d’induire ces effets délétères et la façon dont ses effets sont maintenus et se propagent dans le cerveau restent enc

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37

Nyambura, Lydon Wainaina. "Impact of monocyte differentiation and intracellular infection on processing and presentation of autoantigen." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19154.

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Dendritische Zellen (DCs) und Makrophagen sind spezialisierte antigenpräsentierende Zellen, die eigene und fremde Antigene prozessieren und mittels Haupthistokompatibilitätsmoleküle, humane Leukozytenantige (HLA) im Menschen, T-Zellen präsentieren, um Toleranzen zu induzieren oder T-Zell-vermittelte Immunantworten zu initiieren. Abhängig von ihrer Differenzierung haben sie spezifische Phänotypen und Funktionen undunterschiedliche Interaktionen mit Pathogenen, in dieser Arbeit durch Leishmania donovani (LD) repräsentiert, welche in Phagolysosomen der Makrophagen propagieren. Der Einfluss der D

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38

Massullo, Pam. "Aberrant subcellular targeting of the G185R neutrophil elastase mutant associated with severe congenital neutropenia induces premature apoptosis of differentiating promyelocytes & expression and function of the transient receptor potential 2 (TRPM2) ion channel in dendritic cells." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1172865905.

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39

Araujo, Eliseu Frank de. "Influência da enzima indolamina-2,3-dioxigenase na diferenciação e função das células dendríticas e T reguladoras na paracoccidiodomicose pulmonar de camundongos resistentes e suscetíveis ao Paracoccidioides brasilienses." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-07062014-100532/.

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Paracoccidioidomicose é adquirida pela via respiratória e a enzima indolamina-2,3-dioxigenase (IDO) e o catabolismo do triptofano estão envolvidos no controle da imunidade inata e adaptativa contra patógenos. Investigamos o papel da IDO na doença em animais suscetíveis (B10.A) e resistentes (A/J). Caracterizamos o efeito do tratamento com 1-Metil-DL-Triptofano (1MT) no fenótipo e comportamento de células dendríticas (DCs) e T reguladoras (Tregs) de A/J e B10.A quanto à expressão de IDO. IDO controla a carga fúngica de A/J e B10.A, reduzindo a imunidade de TCD4 e TCD8 e aumentando Tregs. Const

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40

Schwarz, Annika. "Einfluss von Interleukin-10 auf die Differenzierung von Monozyten zu Dendritischen Zellen." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-148424.

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Interleukin-10 ist ein Paradebeispiel eines immunhemmenden Zytokins. Es konnte nachgewiesen werden, dass eine Reihe von Tumoren Interleukin-10 produziert, um einer Antitumor-Immunantwort zu entgehen. Viele Studien haben sich mit dem Einfluss von Interleukin-10 auf die antigenpräsentierenden Fähigkeiten der Dendritischen Zellen beschäftigt. Es gibt eindeutige Hinweise, dass der Effekt von tumorproduziertem Interleukin-10 nicht nur in einer hemmenden Wirkung auf die Ausreifung Dendritischer Zellen besteht, sondern dass Interleukin-10 zu einer Reduktion der Anzahl an Dendritischen Zellen führen

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41

Esplin, Brandt L. "Replenishment of innate immune system in health and disease." Oklahoma City : [s.n.], 2009.

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42

Dental, Clélia. "Effet du virus de l'hépatite C sur les cellules plasmacytoïdes dendritiques." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20657.

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Les cellules dendritiques plasmacytoïdes (pDC) sont responsables de la production d'IFN de type I au cours des infections virales. L'élimination du virus de l’hépatite C (VHC) par une thérapie basée sur l'IFN-α chez plus de 50% des patients chroniquement infectés suggère une diminution possible de la production d'IFN-α endogène par les pDC. Cependant, les pDC exposées à des hépatocytes infectés par le VHC produisent de l'IFN de type I via la signalisation du TLR7. Dans cette étude, nous avons étudié l'impact du virion du VHC sur les différentes fonctions des pDC que sont la production d’IFN-α

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Grandclaudon, Maximilien. "Analyses multivariées de la génération de la diversité des cytokines des cellules T CD4 et association de cette diversité aux différents sous types de cancer du sein." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS286/document.

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Aujourd’hui, plusieurs niveaux de complexité ont émergé dans l’étude des phénotypes T CD4 auxiliaires. 1) le nombre important de cytokines différentes pouvant être secrétées par les lymphocytes T CD4. 2) la multiplicité de signaux pouvant agir durant la différenciation des T CD4 pour spécifier leur profile de sécrétion cytokinique. 3) l’association de ces différents profils de cytokines à des pathologies complexes. Au cours de mon doctorat je me suis concentré sur ces trois niveaux de complexité en étudiant la génération de la diversité cytokinique T CD4 et ses associations aux différents sous

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Llopis, Hernández Virginia. "Material-driven fibronectin fibrillogenesis to engineer cell function." Doctoral thesis, Universitat Politècnica de València, 2017. http://hdl.handle.net/10251/90412.

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This thesis ventures with the extracellular matrix protein (ECM) fibronectin (FN) as an interface protein in the interaction between cells and materials to design microenvironment for future use in tissue engineering. It is studied the FN adsorption and conformations, cell behaviour to different FN conformation, cell adhesion, reorganisation and remodelling of FN at the material interface, the role of growth factors (GF) and their interactions with components of the extracellular matrix (ECM), the immunology cell response, and the stem cell fate influenced by the extrinsic signals coming from

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Chan, Yueh-Hsuan, and 詹月瑄. "Modulatory Effects of Osteoprotegerin on Dendritic Cell Differentiation." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/76564462654672517829.

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碩士<br>國立陽明大學<br>微生物及免疫學研究所<br>92<br>Osteoprotegerin (OPG), a member of tumor necrosis factor receptor superfamily, is a soluble receptor for both TRANCE and TRAIL. It is well known that OPG regulates bone metabolism by blocking the effects of TRANCE to inhibit osteoclast differentiation and activation. Moreover, the bone marrow-derived dendritic cells (DCs) from OPG-/- mice are more efficiently in stimulating allogeneic T cells and secrete elevated amounts of inflammatory cytokines, suggesting OPG plays an important role in the immune response regulating the function of DCs. To understand whet

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林建中. "The effect of hearbs on the differentiation of human dendritic cells." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/54465671259895018051.

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Chen, Kuan-Fu, and 陳冠福. "Effects of phosphodiesterase 4B on mouse dendritic cell differentiation and CXCR4 expression." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/34899864338154276896.

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碩士<br>國立中央大學<br>生命科學系<br>104<br>Dendritic cells (DCs) are antigen presenting cells (APCs) that play a crucial role in the innate and adaptive immunity. Upon capturing antigen, DCs migrate from peripheral tissues to local lymphoid organs, differentiate into APCs, and then activate antigen-specific T cells. It is well known that elevation of intracellular cAMP concentration attenuates many inflammatory responses in almost all inflammatory cell types, including DCs. Type 4 phosphodieasterases (PDE4s) are predominant cAMP-hydrolyzing PDEs in immune/inflammatory cells which affect inflammatory resp

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Rodrigues, Raquel Alcarpe Coelho Gomes. "Evaluation of immunoproteasome inhibition in the differentiation and maturation of dendritic cells." Master's thesis, 2019. http://hdl.handle.net/10451/43380.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019<br>Muitos processos fisiológicos e patológicos dependem do funcionamento do sistema ubiquitina-proteassoma (UPS). Este sistema é responsável pela degradação da maior parte das proteínas nas células eucarióticas. As proteínas são biomoléculas de nitrogénio de elevadas dimensões formadas por resíduos de aminoácidos e que possuem funções complexas que permitem o bom funcionamento do organismo. Deste modo, torna-se essencial manter a integridade celular das proteínas dentro de valores

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Mendes, Cátia da Silva. "Analysis of monocyte-derived dendritic cells obtained through conventional vs. fast differentiation/maturation protocols." Master's thesis, 2019. http://hdl.handle.net/10773/29894.

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Dendritic cells (DCs) are cells specialized in antigen presentation that play an important role in the connection between innate and adaptive immunity. These cells have the unique ability to recognize, capture, process and present antigens to naïve T cells, leading to their polarization in different effector populations. Because of this ability, DCs have been used in recent decades to develop cancer immunotherapy approaches. In this type of cellular immunotherapy, the production of ex vivo DCs is necessary, and there are several protocols for this purpose. The aim of the present work was to co

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Lau, Colleen. "Molecular control of dendritic cell development and function." Thesis, 2015. https://doi.org/10.7916/D8GB234M.

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Abstract:

Dendritic cells (DCs) comprise a distinct lineage of potent antigen-presenting mononuclear phagocytes that serve as both mediators of innate immune responses and key facilitators of the adaptive immune response. DCs play both immunogenic and tolerogenic roles through their dual ability to elicit pathogen-specific T cell immunity as well as induce regulatory T cell (Treg) responses to promote tolerance in the steady state. The aim of the work presented here is to examine the normal regulatory mechanisms of DC development and function, starting with the dissection of mechanisms behind an aberran

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