Academic literature on the topic 'Dendritic arborization'

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Journal articles on the topic "Dendritic arborization"

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Schaefer, Andreas T., Matthew E. Larkum, Bert Sakmann, and Arnd Roth. "Coincidence Detection in Pyramidal Neurons Is Tuned by Their Dendritic Branching Pattern." Journal of Neurophysiology 89, no. 6 (2003): 3143–54. http://dx.doi.org/10.1152/jn.00046.2003.

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Neurons display a variety of complex dendritic morphologies even within the same class. We examined the relationship between dendritic arborization and the coupling between somatic and dendritic action potential (AP) initiation sites in layer 5 (L5) neocortical pyramidal neurons. Coupling was defined as the relative reduction in threshold for initiation of a dendritic calcium AP due to a coincident back-propagating AP. Simulations based on reconstructions of biocytin-filled cells showed that addition of oblique branches of the main apical dendrite in close proximity to the soma ( d < 140 μm
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Chen, Chiung-Ya, Chia-Wen Lin, Chiung-Ying Chang, Si-Tse Jiang, and Yi-Ping Hsueh. "Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology." Journal of Cell Biology 193, no. 4 (2011): 769–84. http://dx.doi.org/10.1083/jcb.201008050.

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Dendritic arborization is a critical neuronal differentiation process. Here, we demonstrate that syndecan-2 (Sdc2), a synaptic heparan sulfate proteoglycan that triggers dendritic filopodia and spine formation, regulates dendritic arborization in cultured hippocampal neurons. This process is controlled by sterile α and TIR motif–containing 1 protein (Sarm1), a negative regulator of Toll-like receptor 3 (TLR3) in innate immunity signaling. We show that Sarm1 interacts with and receives signal from Sdc2 and controls dendritic arborization through the MKK4–JNK pathway. In Sarm1 knockdown mice, de
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Mishra, Archana, Boris Knerr, Sónia Paixão, Edgar R. Kramer, and Rüdiger Klein. "The Protein Dendrite Arborization and Synapse Maturation 1 (Dasm-1) Is Dispensable for Dendrite Arborization." Molecular and Cellular Biology 28, no. 8 (2008): 2782–91. http://dx.doi.org/10.1128/mcb.02102-07.

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ABSTRACT The development of a highly branched dendritic tree is essential for the establishment of functional neuronal connections. The evolutionarily conserved immunoglobulin superfamily member, the protein dendrite arborization and synapse maturation 1 (Dasm-1) is thought to play a critical role in dendrite formation of dissociated hippocampal neurons. RNA interference-mediated Dasm-1 knockdown was previously shown to impair dendrite, but not axonal, outgrowth and branching (S. H. Shi, D. N. Cox, D. Wang, L. Y. Jan, and Y. N. Jan, Proc. Natl. Acad. Sci. USA 101:13341-13345, 2004). Here, we r
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Fujishima, Kazuto, Junko Kurisu, Midori Yamada та Mineko Kengaku. "βIII spectrin controls the planarity of Purkinje cell dendrites by modulating perpendicular axon-dendrite interactions". Development 147, № 24 (2020): dev194530. http://dx.doi.org/10.1242/dev.194530.

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ABSTRACTThe mechanism underlying the geometrical patterning of axon and dendrite wiring remains elusive, despite its crucial importance in the formation of functional neural circuits. The cerebellar Purkinje cell (PC) arborizes a typical planar dendrite, which forms an orthogonal network with granule cell (GC) axons. By using electrospun nanofiber substrates, we reproduce the perpendicular contacts between PC dendrites and GC axons in culture. In the model system, PC dendrites show a preference to grow perpendicularly to aligned GC axons, which presumably contribute to the planar dendrite arbo
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Troilo, David, Meijuan Xiong, Justin C. Crowley, and Barbara L. Finlay. "Factors controlling the dendritic arborization of retinal ganglion cells." Visual Neuroscience 13, no. 4 (1996): 721–33. http://dx.doi.org/10.1017/s0952523800008609.

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AbstractThe effects of changing retinal ganglion cell (RGC) density and availability of presynaptic sites on the development of RGC dendritic arbor in the developing chick retina were contrasted. Visual form deprivation was used to induce ocular enlargement and expanded retinal area resulting in a 20–30% decrease in RGC density. In these retinas, RGC dendritic arbors increased in a compensatory manner to maintain the inner nuclear layer to RGC convergence ratio in a way that is consistent with simple stretching; RGC dendritic arbors become larger with increased branch lengths, but without chan
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Jan, Yuh-Nung, and Lily Yeh Jan. "Branching out: mechanisms of dendritic arborization." Nature Reviews Neuroscience 11, no. 5 (2010): 316–28. http://dx.doi.org/10.1038/nrn2836.

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Kong, Jiming, Vivian W. Y. Tung, John Aghajanian, and Zuoshang Xu. "Antagonistic Roles of Neurofilament Subunits NF-H and NF-M Against NF-L in Shaping Dendritic Arborization in Spinal Motor Neurons." Journal of Cell Biology 140, no. 5 (1998): 1167–76. http://dx.doi.org/10.1083/jcb.140.5.1167.

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Dendrites play important roles in neuronal function. However, the cellular mechanism for the growth and maintenance of dendritic arborization is unclear. Neurofilaments (NFs), a major component of the neuronal cytoskeleton, are composed of three polypeptide subunits, NF-H, NF-M, and NF-L, and are abundant in large dendritic trees. By overexpressing each of the three NF subunits in transgenic mice, we altered subunit composition and found that increasing NF-H and/or NF-M inhibited dendritic arborization, whereas increasing NF-L alleviated this inhibition. Examination of cytoskeletal organizatio
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Keil, Kimberly P., Sunjay Sethi, and Pamela J. Lein. "Sex-Dependent Effects of 2,2′,3,5′,6-Pentachlorobiphenyl on Dendritic Arborization of Primary Mouse Neurons." Toxicological Sciences 168, no. 1 (2018): 95–109. http://dx.doi.org/10.1093/toxsci/kfy277.

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AbstractEarly life exposures to environmental contaminants are implicated in the pathogenesis of many neurodevelopmental disorders (NDDs). These disorders often display sex biases, but whether environmental neurotoxicants act in a sex-dependent manner to modify neurodevelopment is largely unknown. Since altered dendritic morphology is associated with many NDDs, we tested the hypothesis that male and female primary mouse neurons are differentially susceptible to the dendrite-promoting activity of 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95). Hippocampal and cortical neuron-glia co-cultures were exp
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Keeler, Austin B., Dietmar Schreiner та Joshua A. Weiner. "Protein Kinase C Phosphorylation of a γ-Protocadherin C-terminal Lipid Binding Domain Regulates Focal Adhesion Kinase Inhibition and Dendrite Arborization". Journal of Biological Chemistry 290, № 34 (2015): 20674–86. http://dx.doi.org/10.1074/jbc.m115.642306.

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The γ-protocadherins (γ-Pcdhs) are a family of 22 adhesion molecules with multiple critical developmental functions, including the proper formation of dendritic arbors by forebrain neurons. The γ-Pcdhs bind to and inhibit focal adhesion kinase (FAK) via a constant C-terminal cytoplasmic domain shared by all 22 proteins. In cortical neurons lacking the γ-Pcdhs, aberrantly high activity of FAK and of PKC disrupts dendrite arborization. Little is known, however, about how γ-Pcdh function is regulated by other factors. Here we show that PKC phosphorylates a serine residue situated within a phospho
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SCHIERWAGEN, ANDREAS K., and JAAP VAN PELT. "SHAPING NEURONAL DENDRITES: INTERPLAY OF TOPOLOGICAL AND METRICAL PARAMETERS." Journal of Biological Systems 03, no. 04 (1995): 1193–200. http://dx.doi.org/10.1142/s0218339095001076.

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The functional role of a neuron within a network is influenced by the geometry of its dendrites. In the present study we have used a new model of dendritic arborization to analyze how metrical and topological parameters interact to shape a certain dendritic tree. One of the specific questions addressed is how to change topological variability in a systematic way while preserving the metrical features. The second problem concerns the effect of topology on the relationship between dendritic size and the distribution of dendritic surface area with radial distance from soma. The simulation results
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Dissertations / Theses on the topic "Dendritic arborization"

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Garrett, Andrew Weiner Joshua A. "Control of synaptogenesis and dendritic arborization by the [gamma]-Protocadherin family of adhesion molecules." [Iowa City, Iowa] : University of Iowa, 2009. http://ir.uiowa.edu/etd/362.

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Garrett, Andrew. "Control of synaptogenesis and dendritic arborization by the γ-Protocadherin family of adhesion molecules". Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/362.

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During development, the mammalian nervous system wires into a precise network of unrivaled complexity. The formation of this network is regulated by an assortment of molecular cues, both secreted molecules and cell-surface proteins. The ã-Protocadherins (ã-Pcdhs) are particularly good candidates for involvement in these processes. This family of adhesion molecules consists of 22 members, each with diverse extracellular adhesive domains and shared cytoplasmic domains. Thus, cellular interactions with varied adhesive partners can trigger common cytoplasmic responses. Here we investigated the fun
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Karakatsani, Andromachi [Verfasser], and Hans [Akademischer Betreuer] Straka. "LRP4 regulates dendritic arborization and synapse formation in the central nervous system neurons / Andromachi Karakatsani ; Betreuer: Hans Straka." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1120301963/34.

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Handara, Gerry [Verfasser], and Stephan [Akademischer Betreuer] Kröger. "The role of transmembrane-agrin and its receptor complex during dendritic arborization and synaptogenesis / Gerry Handara ; Betreuer: Stephan Kröger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1199265411/34.

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高山, 雄太. "筋萎縮性側索硬化症2型原因遺伝子のショウジョウバエホモログの生体内機能". 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/189376.

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Chassefeyre, Romain. "Rôle de CHMP2B et du complexe ESCRT-III dans le remodelage dans membranes cellulaires : cas des épines dendritiques." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV049/document.

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CHMP2B est une sous-unité du complexe ESCRT-III, un complexe cytosolique très conservé, responsable du remodelage des membranes biologique, dans divers processus cellulaires. Des mutations de CHMP2B sont associées à une forme familiale de démence frontotemporale. Une étude précédente a mis en évidence que les mutants pathogènes de CHMP2B altèrent la morphologie des épines dendritiques, un phénomène potentiellement à l'origine de la maladie. Ce travail de recherche a pour objectif de décrire le rôle de CHMP2B, et du complexe ESCRT-III, dans la structure et le fonctionnement des épines dendritiq
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Ou, Yimiao. "Molecular mechanisms controlling the arborization of dendrites in «Drosophila»." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96940.

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The assembly and function of neural circuits depend on the patterned outgrowth, guidance and targeting of dendrites into appropriate territories during development. As a hallmark of any neuron, cell type-specific dendrite morphology has a crucial role in determining the sensory or synaptic input a neuron receives. Despite recent advances in exploring the molecular and cellular mechanisms that define dendritic architecture, our understanding of dendrite development is still far from complete. In this thesis research, I have taken a genetic screen approach and a candidate molecule approach to di
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Mah, Kar Men. "Unique roles for the C3 gamma-protocadherin isoform in WNT signaling and dendrite arborization." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5964.

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A key component of neural circuit formation is the elaboration of complex dendritic arbors, the pattern of which constrains inputs to the neuron and thus, the information it processes. As such, many neurodevelopmental disorders such as autism and Down, Rett, and Fragile X Syndromes are associated with reduced forebrain dendrite arborization. Identifying molecules involved in regulating dendrite arborization and neural circuitry formation therefore, is a start to understanding these disorders. Nearly 70 cadherin superfamily adhesion molecules are encoded by the Pcdha, Pcdhb, and Pcdhg gene clus
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Keeler, Austin Byler. "Branching out by sticking together: elucidating mechanisms of gamma-protocadherin control of dendrite arborization." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2230.

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Growth of a properly complex dendrite arbor is a vital step in neuronal differentiation and a prerequisite for normal neural circuit formation; likewise, overly dense or sparse dendrite arbors are a key feature of abnormal neural circuit formation and characteristic of many neurodevelopmental disorders. Thus, identifying factors involved in aberrant dendrite complexity and therefore aberrant circuit formation, are necessary to understanding these disorders. In my doctoral work I have elucidated both intracellular and extracellular aspects to the gamma-protocadherins (γ-Pcdhs) that regulate den
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Dimitrova, Svetla. "Physiological Roles of Robo Receptor during dendrite development of the multidendritic arborization neurons of the Drosophila peripheral nervous system." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-78347.

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Book chapters on the topic "Dendritic arborization"

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Gogan, P., Suzanne Tyč-Dumont, S. M. Korogod, and L. P. Savtchenko. "Functional Connections Between the Architecture of the Dendritic Arborization and the Microarchitecture of the Dendritic Membrane." In Neurobiology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-5899-6_23.

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François, Chantal, Jérôme Yelnik, Patricia Arecchi-Bouchhioua, and Gérard Percheron. "Branching Pattern and Geometrical Properties of Dendritic and Axonal Arborizations in the Striato-Pallido-Thalamic System in Macaques." In Advances in Behavioral Biology. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-0194-1_6.

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Kwon, Ester J., Takahiro Soda, and Li-Huei Tsai. "Neurodevelopment and Schizophrenia." In Neurobiology of Mental Illness, edited by Pamela Sklar. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199934959.003.0025.

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A neurodevelopmental model of schizophrenia postulates that some of the key aspects of brain development that normally occur both pre- and post-natally are not occurring correctly, either in time or space. Complex neural circuitry needs to form and be modulated by experience. Classically, proliferation, migration, arborization and myelination occur prenatally. Elaboration and refining of dendritic trees and synapses as well as myelination of the nervous system continues through the first two-decade of life. There are opportunities for genetic and environmental abnormalities and variation to profoundly influence the trajectories of all of these critical functional processes.
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"The Recent Advancement in Rapid Golgi Method and Result Interpretation." In Protocols used in Molecular Biology, edited by Surya Prakash Pandey, Mallikarjuna Rao Gedda, and Abhishek Pathak. BENTHAM SCIENCE PUBLISHERS, 2020. http://dx.doi.org/10.2174/9789811439315120010017.

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The foundation knowledge of recent advancements of neuroscience was based on the Golgi staining observations. This is one of the best approaches to visualise the neuronal cytoarchitecture and complete morphology of neurons with incomparable clarity. This technique is based on the principle of heavy metal impregnation. There are many modifications and advancement occurred to improve the visualization. This chapter will provide the recently used protocols to visuals the neuronal architecture, dendritic arborization and spine density in different brain regions. Along with the manual observation, the present chapter also describes the currently used tools and software for the better understanding and visualisation of neurons.
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Iwasaki, Toshiharu, Kingsley Ibhazehiebo, Junko Kimura-Kuroda, Wataru Miyazaki, Noriaki Shimokawa, and Noriyuki Koibuchi. "Disruption of Thyroid Hormone Receptor-Mediated Transcription, Thyroid Hormone-Induced Purkinje Cell Dendrite Arborization and Granule Cell Neurite Extension by Polybrominated Diphenylethers." In BASIC/TRANSLATIONAL - Endocrine-Disrupting Chemicals. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part1.p4.p1-91.

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