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Dissertations / Theses on the topic 'Dendritic arborization'

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1

Garrett, Andrew Weiner Joshua A. "Control of synaptogenesis and dendritic arborization by the [gamma]-Protocadherin family of adhesion molecules." [Iowa City, Iowa] : University of Iowa, 2009. http://ir.uiowa.edu/etd/362.

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2

Garrett, Andrew. "Control of synaptogenesis and dendritic arborization by the γ-Protocadherin family of adhesion molecules". Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/362.

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During development, the mammalian nervous system wires into a precise network of unrivaled complexity. The formation of this network is regulated by an assortment of molecular cues, both secreted molecules and cell-surface proteins. The ã-Protocadherins (ã-Pcdhs) are particularly good candidates for involvement in these processes. This family of adhesion molecules consists of 22 members, each with diverse extracellular adhesive domains and shared cytoplasmic domains. Thus, cellular interactions with varied adhesive partners can trigger common cytoplasmic responses. Here we investigated the fun
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Karakatsani, Andromachi [Verfasser], and Hans [Akademischer Betreuer] Straka. "LRP4 regulates dendritic arborization and synapse formation in the central nervous system neurons / Andromachi Karakatsani ; Betreuer: Hans Straka." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1120301963/34.

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4

Handara, Gerry [Verfasser], and Stephan [Akademischer Betreuer] Kröger. "The role of transmembrane-agrin and its receptor complex during dendritic arborization and synaptogenesis / Gerry Handara ; Betreuer: Stephan Kröger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1199265411/34.

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5

高山, 雄太. "筋萎縮性側索硬化症2型原因遺伝子のショウジョウバエホモログの生体内機能". 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/189376.

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6

Chassefeyre, Romain. "Rôle de CHMP2B et du complexe ESCRT-III dans le remodelage dans membranes cellulaires : cas des épines dendritiques." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV049/document.

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CHMP2B est une sous-unité du complexe ESCRT-III, un complexe cytosolique très conservé, responsable du remodelage des membranes biologique, dans divers processus cellulaires. Des mutations de CHMP2B sont associées à une forme familiale de démence frontotemporale. Une étude précédente a mis en évidence que les mutants pathogènes de CHMP2B altèrent la morphologie des épines dendritiques, un phénomène potentiellement à l'origine de la maladie. Ce travail de recherche a pour objectif de décrire le rôle de CHMP2B, et du complexe ESCRT-III, dans la structure et le fonctionnement des épines dendritiq
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7

Ou, Yimiao. "Molecular mechanisms controlling the arborization of dendrites in «Drosophila»." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96940.

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The assembly and function of neural circuits depend on the patterned outgrowth, guidance and targeting of dendrites into appropriate territories during development. As a hallmark of any neuron, cell type-specific dendrite morphology has a crucial role in determining the sensory or synaptic input a neuron receives. Despite recent advances in exploring the molecular and cellular mechanisms that define dendritic architecture, our understanding of dendrite development is still far from complete. In this thesis research, I have taken a genetic screen approach and a candidate molecule approach to di
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8

Mah, Kar Men. "Unique roles for the C3 gamma-protocadherin isoform in WNT signaling and dendrite arborization." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5964.

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A key component of neural circuit formation is the elaboration of complex dendritic arbors, the pattern of which constrains inputs to the neuron and thus, the information it processes. As such, many neurodevelopmental disorders such as autism and Down, Rett, and Fragile X Syndromes are associated with reduced forebrain dendrite arborization. Identifying molecules involved in regulating dendrite arborization and neural circuitry formation therefore, is a start to understanding these disorders. Nearly 70 cadherin superfamily adhesion molecules are encoded by the Pcdha, Pcdhb, and Pcdhg gene clus
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9

Keeler, Austin Byler. "Branching out by sticking together: elucidating mechanisms of gamma-protocadherin control of dendrite arborization." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2230.

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Growth of a properly complex dendrite arbor is a vital step in neuronal differentiation and a prerequisite for normal neural circuit formation; likewise, overly dense or sparse dendrite arbors are a key feature of abnormal neural circuit formation and characteristic of many neurodevelopmental disorders. Thus, identifying factors involved in aberrant dendrite complexity and therefore aberrant circuit formation, are necessary to understanding these disorders. In my doctoral work I have elucidated both intracellular and extracellular aspects to the gamma-protocadherins (γ-Pcdhs) that regulate den
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10

Dimitrova, Svetla. "Physiological Roles of Robo Receptor during dendrite development of the multidendritic arborization neurons of the Drosophila peripheral nervous system." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-78347.

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11

Khatri, Natasha. "The autism protein UBE3A/E6AP regulates remodeling of neuronal dendritic arborization." Thesis, 2017. https://hdl.handle.net/2144/23414.

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Autism spectrum disorders (ASDs) are clinically characterized by decreased communication abilities, impaired social interaction, and the occurrence of repetitive behaviors, with high genetic heritability. Ubiquitin protein ligase E3A (UBE3A) is a gene located on human chromosome 15q11-13, a region that has been the focus of genetic studies of susceptibility to ASD AND Angelman syndrome. An increased UBE3A gene dosage and thus an elevated amount of E6AP, the protein product of UBE3A, is associated with ASD. However, the underlying cellular and molecular details remain poorly understood. Normal
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12

Huang, Wayne. "PAKs 1 & 3 Control Postnatal Brain Development and Cognitive Behaviour through Regulation of Axonal and Dendritic Arborizations." Thesis, 2012. http://hdl.handle.net/1807/33708.

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The molecular mechanisms that coordinate postnatal brain enlargement, synaptic properties and cognition remain an enigma. This study demonstrates that neuronal complexity controlled by p21-activated kinases (PAKs) is a key determinant for postnatal brain enlargement and synaptic properties. Double knockout (DK) mice lacking both PAK1 and PAK3 were severely impaired in postnatal brain growth, resulting in a dramatic reduction in brain volume at maturity. Remarkably, the reduced brain was accompanied by minimal changes in total cell count, due to a significant increase in cell density. However,
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13

Castanho, Isabel Maria Sousa. "The impact of phospholipase D genetic ablation in the mouse hippocampus." Master's thesis, 2015. http://hdl.handle.net/1822/46972.

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Dissertação de mestrado em Ciências da Saúde<br>Over the past years increasing amount of attention has been given to signaling lipids as well as to its modulating enzymes, such as phospholipases. Specifically, phospholipase D (PLD), that converts phosphatidylcholine to phosphatidic acid, has been shown to exhibit a role in neurological development and physiology. Several studies have been associating PLD1 and PLD2, the two mammalian PLD isozymes, to neurological events, including neurotransmitter release, dendritic branching, cognition, and brain development. Also, the hippocampus has bee
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14

Li, Hsun, and 李珣. "Study of the Golgi Outpost-localized Proteins Fringe and Lrrk in Dendrite Arborization." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/a825d9.

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15

Dimitrova, Svetla [Verfasser]. "Physiological roles of Robo receptor during dendrite development of the multidendritic arborization neurons of the Drosophila peripheral nervous system / vorgelegt von Svetla Dimitrova." 2007. http://d-nb.info/987872877/34.

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